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https://www.readbyqxmd.com/read/27920487/synchronous-occurrence-of-a-hepatic-myelolipoma-and-two-hepatocellular-carcinomas
#1
Shao-Yan Xu, Hai-Yang Xie, Lin Zhou, Shu-Sen Zheng, Wei-Lin Wang
Myelolipoma is a rare tumor composed of fat and bone marrow components, most of which are located in the adrenal gland. Myelolipoma in the liver is extremely rare. To date, only 10 cases have been reported in the English-language medical literature. In one of these cases, the hepatic myelolipoma was found within a hepatocellular carcinoma (HCC). In the present study, we report the first case of the synchronous occurrence of hepatic myelolipoma and HCCs in different liver sections of one patient, a 26-year-old female who was admitted to our hospital because of a 4-d history of upper abdominal pain...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27920274/adipose-fatty-acid-binding-protein-promotes-saturated-fatty-acid-induced-macrophage-cell-death-through-enhancing-ceramide-production
#2
Yuwen Zhang, Enyu Rao, Jun Zeng, Jiaqing Hao, Yanwen Sun, Shujun Liu, Edward R Sauter, David A Bernlohr, Margot P Cleary, Jill Suttles, Bing Li
Macrophages play a critical role in obesity-associated chronic inflammation and disorders. However, the molecular mechanisms underlying the response of macrophages to elevated fatty acids (FAs) and their contribution to metabolic inflammation in obesity remain to be fully elucidated. In this article, we report a new mechanism by which dietary FAs, in particular, saturated FAs (sFAs), are able to directly trigger macrophage cell death. We demonstrated that excess sFAs, but not unsaturated FAs, induced the production of cytotoxic ceramides (Cers) in macrophage cell lines...
December 5, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#3
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27907211/characterization-and-immunomodulatory-effects-of-canine-adipose-tissue-and-bone-marrow-derived-mesenchymal-stromal-cells
#4
Keith A Russell, Natalie H C Chow, David Dukoff, Thomas W G Gibson, Jonathan LaMarre, Dean H Betts, Thomas G Koch
BACKGROUND: Mesenchymal stromal cells (MSC) hold promise for both cell replacement and immune modulation strategies owing to their progenitor and non-progenitor functions, respectively. Characterization of MSC from different sources is an important and necessary step before clinical use of these cells is widely adopted. Little is known about the biology and function of canine MSC compared to their mouse or human counterparts. This knowledge-gap impedes development of canine evidence-based MSC technologies...
2016: PloS One
https://www.readbyqxmd.com/read/27888602/a-glycovariant-of-human-cd44-is-characteristically-expressed-on-human-mesenchymal-stem-cells
#5
Gisela Pachón-Peña, Conor Donnelly, Catalina Ruiz-Cañada, Adam Katz, Sonia Fernández-Veledo, Joan Vendrell, Robert Sackstein
The clinical effectiveness of systemically-administered human mesenchymal stem cells (hMSCs) depends on their capacity to engage vascular endothelium. hMSCs derived from bone marrow (BM-hMSCs) natively lack endothelial binding capacity but express a CD44 glycovariant containing N-linked sialyllactosamines that can be α(1,3)-fucosylated using fucosyltransferase- VI (FTVI) to enforce sLe(X) decorations, thereby creating hematopoietic cell E-/L-selectin ligand (HCELL). HCELL expression programs potent shear-resistant adhesion of circulating cells to endothelial beds expressing E-selectin...
November 26, 2016: Stem Cells
https://www.readbyqxmd.com/read/27883074/adipose-stem-cells-display-higher-regenerative-capacities-and-more-adaptable-electro-kinetic-properties-compared-to-bone-marrow-derived-mesenchymal-stromal-cells
#6
Ahmed El-Badawy, Marwa Amer, Reda Abdelbaset, Sameh N Sherif, Marwan Abo-Elela, Yehya H Ghallab, Hamdy Abdelhamid, Yehea Ismail, Nagwa El-Badri
Adipose stem cells (ASCs) have recently emerged as a more viable source for clinical applications, compared to bone-marrow mesenchymal stromal cells (BM-MSCs) because of their abundance and easy access. In this study we evaluated the regenerative potency of ASCs compared to BM-MSCs. Furthermore, we compared the dielectric and electro-kinetic properties of both types of cells using a novel Dielectrophoresis (DEP) microfluidic platform based on a printed circuit board (PCB) technology. Our data show that ASCs were more effective than BM-MSCs in promoting neovascularization in an animal model of hind-limb ischemia...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882169/efficacy-of-mesenchymal-stem-cells-in-treating-patients-with-osteoarthritis-of-the-knee-a-meta-analysis
#7
Gang-Hua Cui, Yang Yang Wang, Chang-Jun Li, Chen-Hui Shi, Wei-Shan Wang
To assess the clinical efficacy and safety of mesenchymal stem cell (MSC) treatment for osteoarthritis of the knee (KOA), a systematic electronic literature search was performed on PubMed, EMBASE and Web of Science. Studies published in English from the earliest record to December 2014 were searched using the following keywords: Cartilage defect, cartilage repair, osteoarthritis, KOA, stem cells, MSCs, bone marrow concentrate (BMC), adipose-derived mesenchymal stem cells, synovial-derived mesenchymal stem cells and peripheral blood-derived mesenchymal stem cells...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27881051/mechanisms-of-immune-suppression-utilized-by-canine-adipose-and-bone-marrow-derived-mesenchymal-stem-cells
#8
Lyndah Chow, Valerie Johnson, Jonathan W Coy, Daniel P Regan, Steven W Dow
Mesenchymal stem cells (MSC) from rodents and humans have been shown to suppress T cells by distinct primary pathways, with NO-dependent pathways dominating in rodents and IDO-dependent pathways dominating in humans. However, the immune suppressive pathways utilized by canine MSC have not been as thoroughly studied, nor have BM-MSC and Ad-MSC been directly compared for their immune modulatory potency or pathway utilization. Therefore, canine BM-MSC and Ad-MSC were generated in vitro and their potency in suppressing T cell proliferation and cytokine production was compared, as well as differential gene expression...
November 23, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27872012/biomimetic-collagen-elastin-meshes-for-ventral-hernia-repair-in-a-rat-model
#9
Silvia Minardi, Francesca Taraballi, Xin Wang, Fernando J Cabrera, Jeffrey L Van Eps, Andrew B Robbins, Monica Sandri, Michael R Moreno, Bradley K Weiner, Ennio Tasciotti
: Ventral hernia repair remains a major clinical need. Herein, we formulated a type I collagen/elastin crosslinked blend (CollE) for the fabrication of biomimetic meshes for ventral hernia repair. To evaluate the effect of architecture on the performance of the implants, CollE was formulated both as flat sheets (CollE Sheets) and porous scaffolds (CollE Scaffolds). The morphology, hydrophylicity and in vitro degradation were assessed by SEM, water contact angle and differential scanning calorimetry, respectively...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27871958/current-perspectives-on-stem-cell-therapy-for-erectile-dysfunction
#10
REVIEW
Taylor C Peak, James Anaissie, Wayne J G Hellstrom
INTRODUCTION: Erectile dysfunction (ED) is a common sexual disorder that affects the lives of millions of male patients and their partners. Various medical and surgical therapies exist, with the most common being oral intake of phosphodiesterase 5 inhibitors. One therapeutic strategy in preclinical development to treat ED is stem cell transplantation. AIM: To examine the studies that have investigated stem cells for the treatment of ED. METHODS: A literature review was performed through PubMed focusing on stem cells and ED...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27871812/effects-of-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-on-bone-mineral-density-and-marrow-adipose-tissue
#11
Miriam A Bredella, Logan B Greenblatt, Alireza Eajazi, Martin Torriani, Elaine W Yu
Bariatric surgery is associated with bone loss but skeletal consequences may differ between Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed bariatric procedures. Furthermore, severe weight loss is associated with high marrow adipose tissue (MAT); however, MAT is also increased in visceral adiposity. The purpose of our study was to determine the effects of RYGB and SG on BMD and MAT. We hypothesized that both bariatric procedures would lead to a decrease in BMD and MAT...
November 15, 2016: Bone
https://www.readbyqxmd.com/read/27871224/insights-into-the-human-mesenchymal-stromal-stem-cell-identity-through-integrative-transcriptomic-profiling
#12
Beatriz Roson-Burgo, Fermin Sanchez-Guijo, Consuelo Del Cañizo, Javier De Las Rivas
BACKGROUND: Mesenchymal Stromal/Stem Cells (MSCs), isolated under the criteria established by the ISCT, still have a poorly characterized phenotype that is difficult to distinguish from similar cell populations. Although the field of transcriptomics and functional genomics has quickly grown in the last decade, a deep comparative analysis of human MSCs expression profiles in a meaningful cellular context has not been yet performed. There is also a need to find a well-defined MSCs gene-signature because many recent biomedical studies show that key cellular interaction processes (i...
November 21, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27862947/osteogenic-potential-of-stem-cells-seeded-bioactive-nanocomposite-scaffolds-a-comparative-study-between-human-mesenchymal-stem-cells-derived-from-bone-umbilical-cord-wharton-s-jelly-and-adipose-tissue
#13
Saeid Kargozar, Masoud Mozafari, Seyed Jafar Hashemian, Peiman Brouki Milan, Sepideh Hamzehlou, Mansooreh Soleimani, Mohammad Taghi Joghataei, Mazaher Gholipourmalekabadi, Alireza Korourian, Kazem Mousavizadeh, Alexander M Seifalian
Bone regeneration is considered as an unmet clinical need, the aim of this study is to investigate the osteogenic potential of three different mesenchymal stem cells (MSCs) derived from human bone marrow (BM-MSCs), umbilical cord Wharton's jelly (UC-MSCs), and adipose (AD-MSCs) seeded on a recently developed nanocomposite scaffold (bioactive glass/gelatin) implanted in rat animal models with critical size calvarial defects. In this study, after isolation, culture, and characterization, the MSCs were expanded and seeded on the scaffolds for in vitro and in vivo studies...
November 15, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27861655/comparative-study-between-mesenchymal-stem-cells-derived-from-bone-marrow-and-from-adipose-tissue-associated-with-xenograft-in-appositional-reconstructions-histomorphometric-study-in-rabbit-calvaria
#14
Andrea Baptista Coelho de Faria, Fernando Biolcati Chiantia, Marcelo Lucchesi Teixeira, Antonio Carlos Aloise, André Antonio Pelegrine
PURPOSE: This study analyzed the use of bone marrow-derived mesenchymal stem cells and adipose tissue-derived stem cells, associated with xenograft, in appositional reconstructions in rabbit calvaria using histomorphometry. MATERIALS AND METHODS: Fifteen New Zealand rabbits, weighing 3.5 to 4.0 kg and aged between 10 and 12 months, were randomly divided into three groups. Appositional bone reconstruction situations were created in the calvaria of the animals using titanium cylinders, fitted with titanium occlusive caps...
November 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27855539/mouse-p2y4-nucleotide-receptor-is-a-negative-regulator-of-cardiac-adipose-derived-stem-cell-differentiation-and-cardiac-fat-formation
#15
Anne Lemaire, Marion Vanorlé, Michael Horckmans, Larissa di Pietrantonio, Sophie Clouet, Bernard Robaye, Jean-Marie Boeynaems, Didier Communi
Cardiac adipose-derived stem cells (cASCs) have the ability to differentiate into multiple cell lineages giving them a high potential for use in regenerative medicine. Cardiac fat tissue still raises many unsolved questions related to its formation and features. P2Y nucleotide receptors have already been described as regulators of differentiation of bone-marrow derived stem cells but remain poorly investigated in cASCs. We defined here the P2Y4 nucleotide receptor as a negative regulator of cardiac fat formation and cASC differentiation...
November 17, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27842921/suppression-of-osteoblast-related-genes-during-osteogenic-differentiation-of-adipose-tissue-derived-stromal-cells
#16
Yahya Açil, Amir Alexander Ghoniem, Aydin Gülses, Tobias Kisch, Felix Stang, Jörg Wiltfang, Matthias Gierloff
Recent studies indicated a lower osteogenic differentiation potential of adipose tissue-derived stromal cells (ASCs) compared to bone marrow derived mesenchymal stromal cells. The aim of this study was to evaluate the effects of potent combinations of highly osteogenic bone morphogenetic proteins (BMPs) in order to enhance the osteogenic differentiation potential of ASCs. Human ASCs were cultured for 10 days in the presence of osteogenic medium consisting of dexamethasone, ß-glycerophosphate and ascorbat-2-phosphate (OM) supplemented with BMP-2, BMP-6, BMP-9+IGF-2 and BMP-2,-6,-9 (day 1+2: 50 ng/ml, days 3-6: 100 ng/ml, days 7-10: 200 ng/ml)...
October 18, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27837561/banking-of-adipose-and-cord-tissue-derived-stem-cells-technical-and-regulatory-issues
#17
David T Harris
Stem cells are found in all multicellular organisms and are defined as cells that can differentiate into specialized mature cells as well as divide to produce more stem cells. Mesenchymal stem cells (MSC) were among the first stem cell types to be utilized for regenerative medicine. Although initially isolated from bone marrow, based on ease and costs of procurement, MSC derived from adipose tissue (AT-MSC) and umbilical cord tissue (CT-MSC) are now preferred stem cell sources for these applications. Both adipose tissues and cord tissue present unique problems for biobanking however, in that these are whole tissues, not cellular suspensions...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27832825/heterogeneity-of-proangiogenic-features-in-mesenchymal-stem-cells-derived-from-bone-marrow-adipose-tissue-umbilical-cord-and-placenta
#18
Wen Jing Du, Ying Chi, Zhou Xin Yang, Zong Jin Li, Jun Jie Cui, Bao Quan Song, Xue Li, Shao Guang Yang, Zhi Bo Han, Zhong Chao Han
BACKGROUND: Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular diseases. Because of the invasive method, limited resources, and aging problems of adult tissue-derived MSCs, more perinatal tissue-derived MSCs have been isolated and studied as promising substitutable MSCs for cell transplantation. However, fewer studies have comparatively studied the angiogenic efficacy of MSCs derived from different tissues sources...
November 10, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27826285/qualitative-aspects-of-bone-marrow-adiposity-in-osteoporosis
#19
Ana María Pino, Melissa Miranda, Carolina Figueroa, Juan Pablo Rodríguez, Clifford J Rosen
The function of marrow adipocytes and their origin has not been defined although considerable research has centered on their presence in certain conditions, such as osteoporosis. Less work has focused on the qualitative aspects of marrow fat. Bone marrow serum is composed of multiple nutrients that almost certainly relate to functional aspects of the niche. Previous studies using non-invasive techniques have shown that osteoporotic individuals have more marrow fat and that the ratio of saturated: unsaturated fatty acid is high...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27824667/proton-magnetic-resonance-spectroscopy-detected-changes-of-marrow-fat-content-in-a-rabbit-model-of-osteoporosis-treated-with-epigallocatechin-3-gallate
#20
Yin Liu, Sijie Wu, Rongrong Cui, Qian Chan, Shengwang Zhang, Yunjie Liao, Can Huang
OBJECTIVE: The aim of this study was to longitudinally evaluate the changes in marrow fat content of ovariectomized (OVX) rabbits treated with epigallocatechin-3-gallate (EGCG) using proton magnetic resonance spectroscopy (H-MRS). METHODS: Thirty-six female New Zealand rabbits were equally divided into sham operation, OVX controls, and OVX treated with EGCG (intraperitoneally, 1.8 mg/kg) for 5 months. Marrow fat fraction by H-MRS and bone density by peripheral quantitative computed tomography were determined at 0, 3, and 5 months...
November 7, 2016: Journal of Computer Assisted Tomography
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