keyword
https://read.qxmd.com/read/37993498/the-compensatory-hypertrophy-of-transferred-flexor-hallucis-longus-tendon-for-insertional-achilles-tendinopathy-a-retrospective-mri-study
#21
JOURNAL ARTICLE
Wei-Jen Liao, Shih-Chieh Tang, Han-Ting Shih, Kuo-Chih Su, Kao-Chang Tu, Shun-Ping Wang
Flexor hallucis longus (FHL) transfer is an effective surgery in treating insertional Achilles tendinopathy (IAT). However, limited data exist regarding the post-surgery changes in the transferred FHL. The study aimed to compare the sequential changes and hypertrophy of FHL after isolated FHL transfer (FHLT). We retrospectively enrolled patients who underwent isolated FHLT for insertional Achilles pathology from 2015 to 2020 and divided them into two groups based on whether reattachment of the residue Achilles stump to the FHL was performed or not...
November 22, 2023: Scientific Reports
https://read.qxmd.com/read/37960840/quantitative-assessment-of-calf-muscle-volume-strength-and-quality-after-achilles-tendon-rupture-repair-a-1-year-prospective-follow-up-study
#22
JOURNAL ARTICLE
Shota Mashimo, Taiki Nozaki, Kentaro Amaha, Keita Tanaka, Junya Kubota, Hiroyuki Sato, Nobuto Kitamura
BACKGROUND: A number of studies have reported that calf muscle atrophy is a common long-term problem after Achilles tendon repair; however, there is still a lack of data concerning early postoperative morphological changes in the calf muscle after surgery. PURPOSE: To investigate changes over time in calf muscle volume and fatty degeneration during 1 year after Achilles tendon repair. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A prospective 1-year serial magnetic resonance imaging study was carried out with 20 patients who underwent tendon repair for unilateral acute Achilles tendon rupture...
December 2023: American Journal of Sports Medicine
https://read.qxmd.com/read/37949591/evaluation-of-arthrokinematics-and-posterior-soft-tissues-of-the-ankle-during-ankle-dorsiflexion-using-ultrasound
#23
JOURNAL ARTICLE
Junpei Yoshioka, Tomonari Sugano, Katsunori Mizuno
BACKGROUND: Arthrokinematics (caudal and posterior movements of the talus) and posterior soft tissues of the ankle during ankle dorsiflexion have not been objectively evaluated in detail. This study aimed to investigate the characteristics of arthrokinematics and posterior soft tissues of the ankle during ankle dorsiflexion using ultrasound. METHODS: Thirteen healthy adults participated in the study. Participants whose passive dorsiflexion range of motion (ROM) of the ankle joint was <35° were classified as the restricted group (n = 6), and participants whose passive ankle dorsiflexion ROM was ≥35° were classified as the control group (n = 7)...
October 2023: Journal of Bodywork and Movement Therapies
https://read.qxmd.com/read/37881886/arthroscopic-tenotomy-of-the-flexor-hallucis-longus-to-treat-checkrein-deformity
#24
JOURNAL ARTICLE
Jesús Mudarra García, Natalia Saus Milán, María Carmen Blasco Mollá, Francisco Forriol Brocal, Victor Martin-Gorgojo
Checkrein deformity is a rare entity that results in alteration of the normal flexion and extension of the hallux, caused by a retraction or adhesion of the flexor hallucis longus (FHL) in its tendinous or muscular portion. It is usually caused by the sequelae of ankle and tibia fractures, such as adhesions and neuropathies, and often undiagnosed compartment syndromes. Its treatment is mainly surgical, and different techniques of release or lengthening of the FHL have been described. We present the clinical case of a 61-year-old patient treated by a simple arthroscopic tenotomy of the FHL at the retromalleolar level of the ankle, with complete functional recovery and absence of recurrence after 2 years of evolution...
October 26, 2023: Foot & Ankle Specialist
https://read.qxmd.com/read/37838022/flexor-hallucis-longus%C3%A2-decompression-under-ultrasound-guidance-a-cadaver-study
#25
JOURNAL ARTICLE
Lolita Micicoi, Alexandre Rudel, Solenne Frey-Ollivier, Barbara Piclet-Legré
INTRODUCTION: The Flexor Hallucis Longus (FHL) is a muscle that can be subject to multiple impingements caused by exaggerated plantar flexion in athletes. The most common impingement is due to inflammation of the tendon at the retrotalar pulley. The constraints exerted on the FHL are responsible for a pathology called functional Hallux Limitus. Surgical treatment consists of tenolysis of the FHL arthroscopically or via open surgery, by opening the pulley. The objective of this study was to evaluate the risk of lesions of the neurovascular pedicle and the posterior tibial tendon after tenolysis of the Flexor Hallucis Longus under ultrasound guidance...
December 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/37833696/predictors-for-post-traumatic-hip-osteoarthritis-in-patients-with-transverse-acetabular-fractures-following-open-reduction-internal-fixation-a-minimum-of-2-years-follow-up-multicenter-study
#26
JOURNAL ARTICLE
Junran Li, Lin Jin, Chuanjie Chen, Jingxiu Zhai, Ligeng Li, Zhiyong Hou
BACKGROUND: The predictors of post-traumatic osteoarthritis (PTOA) in patients with transverse acetabular fractures (TAFs) following open reduction internal fixation (ORIF) remain unclear. This study aimed to investigate the risk factors for PTOA in TAFs after ORIF. METHODS: Data of TAF patients receiving ORIF were collected from January 2012 and February 2021. Patients suffered PTOA were classified as the osteoarthritis group (OG), while those without PTOA were classified as the non- osteoarthritis group (NG) with a minimum follow-up of 2 years...
October 13, 2023: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/37810568/surgical-management-of-chronic-achilles-tendon-ruptures-a-systematic-review-and-proposed-treatment-algorithm
#27
JOURNAL ARTICLE
Mohammad T Azam, James J Butler, Matthew B Weiss, Hugo A Ubillus, Noah Kirschner, Nathaniel P Mercer, John G Kennedy
BACKGROUND: As no evidence-based treatment guidelines exist for chronic Achilles tendon rupture (CATR), a systematic review of the literature was performed to compare the different treatment options and recommend a literature-based algorithm. METHODS: In June 2022, MEDLINE, Embase, and Cochrane Library databases were systematically reviewed based on the PRISMA guidelines. The level of evidence (LOE) and quality of evidence were evaluated, and statistics on clinical outcomes and complications were calculated...
October 2023: Foot & ankle orthopaedics
https://read.qxmd.com/read/37773872/long-term-outcome-of-flexor-hallucis-longus-tendon-transfer-for-chronic-achilles-tendon-rupture-with-large-defect-a-retrospective-series
#28
JOURNAL ARTICLE
Yangbo Xu, Cui Li, Tianyu Liu, Feifan Xiang, Yong Deng, Zhong Li, Daiqing Wei
There are multiple surgical options for treatment of chronic Achilles tendon (AT) rupture according to the classifications and length of defect. However, no gold standard method has been confirmed, and there is no clear evidence to support the superiority of 1 procedure over others. This study aimed to evaluate the long-term clinical outcome of flexor hallucis longus tendon (FHL) transfer for chronic AT rupture with large defect. Clinical data of patients treated with FHL transfer due to chronic AT rupture between January 2009 and October 2019 were reviewed retrospectively...
September 29, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37633125/functional-hearing-loss-and-developmental-imbalances
#29
JOURNAL ARTICLE
Muneharu Yamazaki, Tetsuaki Kawase, Naomi Hino-Fukuyo, Tetsuji Morimoto, Hirohito Metoki, Hidetoshi Takahashi, Naru Fukuchi, Yoshitaka Takanashi, Nobuo Ohta
OBJECTIVE: Functional hearing loss (FHL) is a disorder in which there are abnormal values on a hearing test, despite the absence of organic abnormalities in the peripheral and central auditory pathways. Here, we examined the developmental characteristics of FHL and the importance of intervention by analyzing the clinical characteristics of children with this disorder. METHODS: We retrospectively examined 16 patients assessed under a diagnosis of FHL. After interventions such as psychological counseling by our pediatrics and psychiatry departments, we compared the clinical profiles of patients in which hearing was "improved/normalized" and "unimproved"...
August 16, 2023: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/37625231/ankle-fracture-dislocation-with-the-interposition-of-the-tibialis-posterior-tendon-in-the-ankle-syndesmosis-and-tibiotalar-joint-a-case-report-and-systematic-literature-review
#30
Luong Nguyen Van, Gioi Nguyen Nang
INTRODUCTION AND IMPORTANCE: In rare cases of ankle fracture dislocation, PTT can be incarcerated in the ankle syndesmosis. We report a case of a patient who had a fracture-dislocation of the ankle with the interposition of PTT in the ankle syndesmosis and discuss a systematic review of injury mechanics, pathology, diagnosis, management, and outcomes of this injury. CASE PRESENTATION: I reported a 43-year-old patient presented with an irreducible lateral displacement of the talus after ORIF of the malleolar ankle fractures and fixation of ankle syndesmosis...
September 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37611871/-foot-peak-pressures-are-comparable-to-normal-foot-after-flexor-hallucis-longus-transfer-for-chronic-retracted-tendo-achilles-tear-a-pedobarographic-analysis-of-normal-foot-versus-affected-foot
#31
JOURNAL ARTICLE
Rajagopalakrishnan Ramakanth, Silvampatti Ramasamy Sundararajan, Venugopal Thippeswamy, Terence D Souza, Palaniswamy, Shanmuganathan Rajasekaran
INTRODUCTION: Foot pressure changes and morbidity after Flexor hallucis longus(FHL) transfer in chronic retracted Tendoachilles(TA) tears have not been documented. The primary aim of our study is to analyze the peak pressure changes in various zones of the foot at each successive follow-up in the affected foot versus normal foot. The secondary aim is to determine Flexor hallucis longus(FHL) healing and Hypertrophy. METHODS: This is a prospective study of 46 patients who underwent FHL augmentation for retracted TA tears (between 2019-2022)...
August 21, 2023: Journal of ISAKOS
https://read.qxmd.com/read/37543859/the-effect-of-training-type-on-the-signaling-p-athway-of-ceramide-dependent-insulin-resistance-in-the-flexor-hallucis-longus-muscle-of-streptozotocin-induced-diabetic-rats
#32
JOURNAL ARTICLE
Pakhshan Rahimpour, Dariush Sheikholeslami-Vatani, Mohammad Raman Moloudi, Saeed Ghaeeni
OBJECTIVE: This study aimed to compare the effect of different physical training on the mechanism of ceramidedependent insulin resistance in the flexor hallucis longus (FHL) muscle of diabetic rats. MATERIALS AND METHODS: In this experimental study, 7 healthy as a healthy control (HC) group, and 21 diabetics (55 mg/ kg Streptozotocin) Wistar rats (200-220 g; 8-10 weeks old) divided into the diabetic control (DC), moderate continuous training (MCT), and moderate intensity interval training (MIIT) groups...
July 25, 2023: Cell Journal
https://read.qxmd.com/read/37516815/cxcl9-inhibition-does-not-ameliorate-disease-in-murine-models-of-both-primary-and-secondary-hemophagocytic-lymphohistiocytosis
#33
JOURNAL ARTICLE
Tamir Diamond, Michelle Lau, Jeremy Morrissette, Niansheng Chu, Edward M Behrens
Hemophagocytic Lymphohistiocytosis (HLH) is a group of disorders culminating in systemic inflammation and multi-organ failure with high incidence of hepatic dysfunction. Overproduction of IFN-γ is the main immunopathological driver in this disorder. Monokine induced by IFN-γ (CXCL9) serves as a biomarker for disease activity and response to treatment in this disorder. However, very little is understood about the actual functional role of CXCL9 in pathogenesis in HLH. In the current study, we sought to determine the role of CXCL9 in pathogenesis in murine models of both Familial HLH (prf1-/- ) and Toll Like Receptor (TLR) 9 repeated stimulation induced Macrophage Activation Syndrome (MAS), a form of secondary HLH...
July 29, 2023: Scientific Reports
https://read.qxmd.com/read/37499083/treatment-of-crow-s-feet-lines-and-forehead-lines-with-botox-onabotulinumtoxina-development-insights-and-impact
#34
JOURNAL ARTICLE
Alastair Carruthers, Jean Carruthers, Koenraad De Boulle, Nicholas Lowe, Elisabeth Lee, Mitchell F Brin
Extrinsic and age-related intrinsic factors contribute to the development of facial lines, including lateral canthal lines (called crow's feet lines [CFL]) and horizontal forehead lines (FHL). OnabotulinumtoxinA is a highly effective treatment for facial lines that inhibits acetylcholine release at the neuromuscular junction. This temporary chemical denervation leads to localized muscle relaxation and subsequent wrinkle reduction. Early studies of onabotulinumtoxinA treatment for facial neuronal disorders such as dystonia documented improvements in FHL and CFL...
July 1, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37481203/endoscopic-flexor-hallucis-longus-tendon-transfer-with-horizontal-calcaneal-fixation-and-suturing-onto-itself
#35
JOURNAL ARTICLE
Alexis Thiounn, Pierre Auzias, Alexandre Hardy
Endoscopic flexor hallucis longus (FHL) tendon transfer to replace the calcaneal tendon is being increasingly performed. The main advantage is minimisation of approach-related morbidity. Fixation of the FHL tendon is usually achieved with a tenodesis screw placed in a vertical calcaneal tunnel. Here, we describe an endoscopic technique with FHL fixation by tenodesis in a horizontal calcaneal tunnel combined with suturing of the tendon onto itself.
July 20, 2023: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://read.qxmd.com/read/37471073/aav-gene-augmentation-of-truncated-complement-factor-h-differentially-rescues-ocular-complement-dysregulation-in-a-mouse-model
#36
JOURNAL ARTICLE
Daniel Grigsby, Mikael Klingeborn, Una Kelly, Lindsey A Chew, Aravind Asokan, Garth Devlin, Sharon Smith, Lisa Keyes, Adrian Timmers, Abraham Scaria, Catherine Bowes Rickman
PURPOSE: Complement dysregulation in the eye has been implicated in the pathogenesis of age-related macular degeneration (AMD), and genetic variants of complement factor H (CFH) are strongly associated with AMD risk. We therefore aimed to untangle the role of CFH and its splice variant, factor H-like 1 (FHL-1), in ocular complement regulation derived from local versus circulating sources. We assessed the therapeutic efficacy of adeno-associated viruses (AAVs) expressing human FHL-1 and a truncated version of CFH (tCFH), which retains the functional N- and C-terminal ends of the CFH protein, in restoring the alternative complement pathway in Cfh-/- mouse eyes and plasma...
July 3, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37458778/application-of-ultrasound-in-preoperative-localization-diagnosis-of-checkrein-deformity-a-retrospective-case-series
#37
JOURNAL ARTICLE
Yu Yuan, Jinmei Gao, Jun Jia
BACKGROUND: Checkrein deformity, is a rare claw toe dynamic deformity of the hallux or great toe. This study investigated the use of diagnostic ultrasound in positioning the accurate injury location causing checkrein deformity and its clinical significance for etiological diagnosis and selection of surgical methods. METHODS: This retrospective study included patients with confirmed checkrein deformities (according to typical symptoms) at the Department of Traumatic Orthopedics of Tianjin Hospital (Tianjin, China) from March 2017 to July 2021...
2023: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/37434686/comprehensive-pan-cancer-analysis-identifies-fhl2-associated-with-poor-prognosis-in-lung-adenocarcinoma
#38
JOURNAL ARTICLE
Bin Pan, Li Wan, Yu Li, Jian Yang, Zhike Chen, Xin Tong, Jun Zhao, Chang Li
BACKGROUND: The FHL family (four-and-a-half-LIM-only protein family) contains five multifunctional proteins (FHL1-5) that are involved in cell survival, transcriptional regulation, and signal transduction. Among these proteins, FHL2 is one of the most reported members in tumors, which is differentially expressed in numerous tumors. However, no systematic pan-cancer analysis of FHL2 has been performed so far. METHODS: We obtained The Cancer Genome Atlas (TCGA) expression profiles and clinical data from Xena database and the Tumor Immune Estimation Resource (TIMER) database...
June 30, 2023: Translational Cancer Research
https://read.qxmd.com/read/37426667/approaching-hemophagocytic-lymphohistiocytosis
#39
REVIEW
Aurora Chinnici, Linda Beneforti, Francesco Pegoraro, Irene Trambusti, Annalisa Tondo, Claudio Favre, Maria Luisa Coniglio, Elena Sieni
Hemophagocytic Lymphohistiocytosis (HLH) is a rare clinical condition characterized by sustained but ineffective immune system activation, leading to severe and systemic hyperinflammation. It may occur as a genetic or sporadic condition, often triggered by an infection. The multifaceted pathogenesis results in a wide range of non-specific signs and symptoms, hampering early recognition. Despite a great improvement in terms of survival in the last decades, a considerable proportion of patients with HLH still die from progressive disease...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37390248/familial-hemophagocytic-phohistiocytosis-induced-by-prf1-mutation-with-neurologic-manifestations-as-the-initial-clinical-presentations-a-case-report
#40
JOURNAL ARTICLE
Yang You, Wenjuan Wu, Baoguang Li
BACKGROUND: To investigate the clinical characteristics of familial hemophagocytic phohistiocytosis (FHL) induced by PRF1 gene mutation and with central nervous injury as the initial presentation. CASE PRESENTATION: Herein, we presented 2 cases of a familial hemophagocytic syndrome caused by PRF1 gene mutation in 1 family with central nervous injury as the first symptom and searched relevant literature for clinical analysis of its pathogenic characteristics. Two children from 1 family were included in this study, both of whom had complex heterozygous mutations of C...
June 30, 2023: Medicine (Baltimore)
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