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https://www.readbyqxmd.com/read/28926379/tendon-length-calf-muscle-atrophy-and-strength-deficit-after-acute-achilles-tendon-rupture-long-term-follow-up-of-patients-in-a-previous-study
#1
Juuso Heikkinen, Iikka Lantto, Juuso Piilonen, Tapio Flinkkilä, Pasi Ohtonen, Pertti Siira, Vesa Laine, Jaakko Niinimäki, Ari Pajala, Juhana Leppilahti
BACKGROUND: In this prospective study, we used magnetic resonance imaging (MRI) to assess long-term Achilles tendon length, calf muscle volume, and muscle fatty degeneration after surgery for acute Achilles tendon rupture. METHODS: From 1998 to 2001, 60 patients at our center underwent surgery for acute Achilles tendon rupture followed by early functional postoperative rehabilitation. Fifty-five patients were reexamined after a minimum duration of follow-up of 13 years (mean, 14 years), and 52 of them were included in the present study...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28913923/an-ipsc-patient-specific-model-of-cfh-y402h-polymorphism-displays-characteristic-features-of-amd-and-indicates-a-beneficial-role-for-uv-light-exposure
#2
Dean Hallam, Joseph Collin, Sanja Bojic, Valeria Chichagova, Adriana Buskin, Yaobo Xu, Lucia Lafage, Elsje G Otten, George Anyfantis, Carla Mellough, Stefan Przyborski, Sameer Alharthi, Viktor Korolchuk, Andrew Lotery, Gabriele Saretzki, Martin McKibbin, Lyle Armstrong, David Steel, David Kavanagh, Majlinda Lako
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease, however these do not exist for the dry form. Complement factor H (CFH) polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, retinal pigment epithelium (RPE) damage and visual decline...
September 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28863723/flexor-digitorum-longus-fdl-or-flexor-hallucis-longus-fhl-harvesting-technical-tip-and-case-studies
#3
Bruce Lehnert, Meir Nyska, Wing Ip, Em Huynh, Ezequiel Palmanovich
BACKGROUND: Harvesting of the flexor digitorum longus (FDL) or the flexor hallucis longus (FHL) is a procedure used when tendon transfer is needed. It is commonly used in tibialis posterior reconstruction and Achilles tendon reconstruction. Harvesting of these tendons is sometimes difficult and time-consuming. It is important to obtain sufficient length to make a loop around the navicular bone or anchor it in the calcaneus. We describe a technique in which a loop is passed from proximal identification of the FDL or FHL through the tendon sheath, harvesting it from a minimal plantar approach...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28800559/assessment-of-health-literacy-among-outpatient-clinics-attendees-at-ain-shams-university-hospitals-egypt-a-cross-sectional-study
#4
R Almaleh, Y Helmy, E Farhat, H Hasan, A Abdelhafez
OBJECTIVES: The aim of conducting this study is to measure health literacy (HL) and to investigate the factors associated with inadequate HL in a sample of outpatient clinics attendees (i.e. patients and companions) at Ain Shams University (ASU) Hospitals. STUDY DESIGN: It is a cross-sectional study. METHODS: The study was conducted on 805 attendees of the outpatient clinics at El-Demerdash University Hospital of ASU Hospitals. The Arabic versions of the Swedish Functional Health Literacy Scale and the European Health Literacy Survey Questionnaire-short version-were used to assess HL...
August 8, 2017: Public Health
https://www.readbyqxmd.com/read/28757574/finding-a-balance-between-protection-and-pathology-the-dual-role-of-perforin-in-human-disease
#5
REVIEW
Robin C Willenbring, Aaron J Johnson
Perforin is critical for controlling viral infection and tumor surveillance. Clinically, mutations in perforin are viewed as unfavorable, as lack of this pore-forming protein results in lethal, childhood disease, familial hemophagocytic lymphohistiocytosis type 2 (FHL 2). However, many mutations in the coding region of PRF1 are not yet associated with disease. Animal models of viral-associated blood-brain barrier (BBB) disruption and experimental cerebral malaria (ECM) have identified perforin as critical for inducing pathologic central nervous system CNS vascular permeability...
July 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28718449/the-dual-function-chaperone-hych-improves-assembly-of-the-formate-hydrogenlyase-complex
#6
Ute Lindenstrauß, Philipp Skorupa, Jennifer S McDowall, Frank Sargent, Constanze Pinske
The assembly of multi-protein complexes requires the concerted synthesis and maturation of its components and subsequently their co-ordinated interaction. The membrane-bound formate hydrogenlyase (FHL) complex is the primary hydrogen-producing enzyme in Escherichia coli and is composed of seven subunits mostly encoded within the hycA-I operon for [NiFe]-hydrogenase-3 (Hyd-3). The HycH protein is predicted to have an accessory function and is not part of the final structural FHL complex. In this work, a mutant strain devoid of HycH was characterised and found to have significantly reduced FHL activity due to the instability of the electron transfer subunits...
August 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28641911/image-fusion-of-real-time-ultrasonography-with-computed-tomography-factors-affecting-the-registration-error-and-motion-of-focal-hepatic-lesions
#7
Min Woo Lee, Hyun Jeong Park, Tae Wook Kang, Jiwon Ryu, Won-Chul Bang, Bora Lee, Eun Sun Lee, Byung Ihn Choi
Factors affecting the registration error (RE) and motion of focal hepatic lesions (FHLs) in image fusion of real-time ultrasonography (US) with computed tomography (CT) images were prospectively assessed by focusing on respiratory movement and FHL location. Real-time US and pre-acquired CT images at end-inspiration were fused with FHLs for 103 patients. Three-dimensional US data containing FHLs were obtained during end-inspiratory/expiratory phases. Multivariate analysis revealed that diaphragm motion (p < 0...
September 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28640740/differential-effects-of-isc-operon-mutations-on-the-biosynthesis-and-activity-of-key-anaerobic-metalloenzymes-in-escherichia-coli
#8
Monique Jaroschinsky, Constanze Pinske, R Gary Sawers
Escherichia coli has two machineries for the synthesis of FeS clusters, namely Isc (iron-sulfur cluster) and Suf (sulfur formation). The Isc machinery, encoded by the iscRSUA-hscBA-fdx-iscXoperon, plays a crucial role in the biogenesis of FeS clusters for the oxidoreductases of aerobic metabolism. Less is known, however, about the role of ISC in the maturation of key multi-subunit metalloenzymes of anaerobic metabolism. Here, we determined the contribution of each iscoperon gene product towards the functionality of the major anaerobic oxidoreductases in E...
June 22, 2017: Microbiology
https://www.readbyqxmd.com/read/28630760/treatment-of-hindfoot-and-ankle-pathologies-with-posterior-arthroscopic-techniques
#9
Tahir Ögüt, N Selcuk Yontar
The two-portal hindfoot arthroscopy is an effective procedure enabling direct visualisation of posterior ankle pathology with low invasiveness.An important stage of the hindfoot endoscopy is localisation of the flexor hallucis longus (FHL) tendon to protect the neurovascular bundle which is located just medial to it.Posterior ankle impingement syndrome and FHL tenosynovitis are common causes of posterior ankle pain and frequently occur together.Posteriorly localised talar osteochondral lesions, Achilles tendon disorders, osteoarthritis, talar bone cysts and talar fractures are among the other pathologies that can be treated with hindfoot arthroscopy...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28580249/endoscopic-adhesiolysis-of-flexor-hallucis-longus-muscle
#10
Tun Hing Lui
Adhesion of the flexor hallucis longus (FHL) muscle to the distal tibia can occur after distal tibial fracture, distal fibular fracture, low tibial osteotomy, soft-tissue injury at the posterior ankle, subclinical compartment syndrome of the distal deep posterior compartment of the leg, or Volkmann contracture after deep posterior compartment syndrome of the leg. The purpose of this Technical Note is to report the endoscopic approach of FHL muscle adhesiolysis. It is indicated in patients with symptomatic adhesion of the FHL muscle and contraindicated if there is entrapment of the FHL muscle or tendon in the fracture callus or if there is extensive fibrosis and contracture of the FHL muscle as a result of Volkmann contracture after deep posterior compartment syndrome of the leg...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28562814/comprehension-of-the-education-handout-and-health-literacy-of-pacemaker-users
#11
Jackelline Evellin Moreira Dos Santos, Virginia Visconde Brasil, Katarinne Lima Moraes, Jacqueline Andréia Bernardes Leão Cordeiro, Gabriela Ferreira de Oliveira, Carla de Paula Bernardes, Bárbara Ribeiro Miquelin Bueno, Rafaela Peres Boaventura, Fernanda Alves Ferreira Gonçalves, Lizete Malagoni de Almeida Cavalcante Oliveira, Maria Alves Barbosa, Antonio Márcio Teodoro Cordeiro Silva
Objective: To verify the comprehension of the education handout and the level of Functional Health Literacy of individuals with cardiac pacemaker (PM) and whether there is correlation between the comprehension and Functional Health Literacy (FHL). Method: Cross-sectional study with 63 individuals with PM who answered to comprehension tests of the handout, literacy assessment (SAHLPA-50) and cognition (MMSE). Measurements of dispersion, Pearson correlation and multiple linear regression were calculated...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28489964/specific-activation-of-plekhg2-induced-serum-response-element-dependent-gene-transcription-by-four-and-a-half-lim-domains-fhl-1-but-not-fhl2-or-fhl3
#12
Masashi Nishikawa, Katsuya Sato, Shun Nakano, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda
PLEKHG2 is a Gβγ- and Gαs-dependent guanine nucleotide exchange factor for Rac1 and Cdc42 small GTPases and has been shown to mediate signaling pathways such as those for actin cytoskeletal reorganization and serum response element (SRE)-dependent gene transcription. We have shown that the four-and-a-half LIM domains (FHL) 1 acts as a positive regulator of PLEKHG2. Here, we evaluated the other FHL family members and found that the FHL1A specifically regulate the PLEKHG2 activity. Moreover, FHL1A further enhanced Gβγ- and PLEKHG2-induced SRE-dependent gene transcription, whereas FHL1A partially restored the attenuated PLEKHG2-induced SRE-dependent gene transcription by Gαs...
May 10, 2017: Small GTPases
https://www.readbyqxmd.com/read/28488566/expanding-the-substrates-for-a-bacterial-hydrogenlyase-reaction
#13
Ciaran M Lamont, Ciarán L Kelly, Constanze Pinske, Grant Buchanan, Tracy Palmer, Frank Sargent
Escherichia coli produces enzymes dedicated to hydrogen metabolism under anaerobic conditions. In particular, a formate hydrogenlyase (FHL) enzyme is responsible for the majority of hydrogen gas produced under fermentative conditions. FHL comprises a formate dehydrogenase (encoded by fdhF) linked directly to [NiFe]-hydrogenase-3 (Hyd-3), and formate is the only natural substrate known for proton reduction by this hydrogenase. In this work, the possibility of engineering an alternative electron donor for hydrogen production has been explored...
May 10, 2017: Microbiology
https://www.readbyqxmd.com/read/28460573/biomechanical-analysis-of-suture-anchor-vs-tenodesis-screw-for-fhl-transfer
#14
Mark C Drakos, Michael Gott, Sydney C Karnovsky, Conor I Murphy, Bridget A DeSandis, Noah Chinitz, Daniel Grande, Nadeen Chahine
BACKGROUND: Chronic Achilles injury is often treated with flexor hallucis longus (FHL) tendon transfer to the calcaneus using 1 or 2 incisions. A single incision avoids the risks of extended dissections yet yields smaller grafts, which may limit fixation options. We investigated the required length of FHL autograft and biomechanical profiles for suture anchor and biotenodesis screw fixation. METHODS: Single-incision FHL transfer with suture anchor or biotenodesis screw fixation to the calcaneus was performed on 20 fresh cadaveric specimens...
July 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28413452/ankle-and-toe-muscle-strength-characteristics-in-runners-with-a-history-of-medial-tibial-stress-syndrome
#15
Junya Saeki, Masatoshi Nakamura, Sayaka Nakao, Kosuke Fujita, Ko Yanase, Katsuyuki Morishita, Noriaki Ichihashi
BACKGROUND: A high proportion of flexor digitorum longus attachment is found at the posteromedial border of the tibia, which is the most common location of medial tibial stress syndrome (MTSS). Therefore, plantar flexion strength of the lesser toes could be related to MTSS; however, the relationship between MTSS and muscle strength of the hallux and lesser toes is not yet evaluated due to the lack of quantitative methods. This study investigated the muscle strength characteristics in runners with a history of MTSS by using a newly developed device to measure the muscle strength of the hallux, lesser toes, and ankle...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28399723/germline-heterozygous-variants-in-genes-associated-with-familial-hemophagocytic-lymphohistiocytosis-as-a-cause-of-increased-bleeding
#16
Marcus Fager Ferrari, Eva Leinoe, Maria Rossing, Eva Norström, Karin Strandberg, Tobias Steen Sejersen, Klaus Qvortrup, Eva Zetterberg
Familial hemophagocytic lymphohistiocytosis (FHL) is caused by biallelic variants in genes regulating granule secretion in cytotoxic lymphocytes. In FHL3-5, the affected genes UNC13D, STX11 and STXBP2 have further been shown to regulate the secretion of platelet granules, giving rise to compromised platelet function. Therefore, we aimed to investigate platelet degranulation in patients heterozygous for variants in UNC13D, STX11 and STXBP2. During the work-up of patients referred to the Coagulation Unit, Skåne University Hospital, Malmö, Sweden and the Department of Hematology, Rigshospitalet, Copenhagen, Denmark due to bleeding tendencies, 12 patients harboring heterozygous variants in UNC13D, STX11 or STXBP2 were identified using targeted whole exome sequencing...
April 11, 2017: Platelets
https://www.readbyqxmd.com/read/28394676/communication-of-contrast-in-the-flexor-hallucis-longus-tendon-with-other-pedal-tendons-at-the-master-knot-of-henry
#17
Sayed Ali, Nicole L Griffin, Whitney Ellis, Andrew J Meyr
It is important to have a full appreciation of lower-extremity anatomical relationships before undertaking diabetic foot surgery. We sought to evaluate the potential for communication of the flexor hallucis longus (FHL) tendon with other pedal tendons and plantar foot compartments at the master knot of Henry and to provide cadaveric images and computed tomographic (CT) scans of such communications. Computed tomography and subsequent anatomical dissection were performed on embalmed cadaveric limbs. Initially, 5 to 10 mL (1:4 dilution) of iohexol and normal saline was injected into the FHL sheath as it coursed between the two hallux sesamoids...
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28292571/health-literacy-and-quality-of-care-of-patients-with-diabetes-a-cross-sectional-analysis
#18
Emilie Zuercher, Ibrahima Dina Diatta, Bernard Burnand, Isabelle Peytremann-Bridevaux
BACKGROUND: Limited health literacy (HL) may lead to poor health outcomes and inappropriate healthcare use, particularly in patients with chronic diseases. We aimed to assess the association between functional HL (FHL) and quality of care, as measured by process- and outcome-of-care indicators, in patients with diabetes. METHODS: This cross-sectional study used data from the 2013 CoDiab-VD cohort follow-up, which included non-institutionalised adults with diabetes from canton of Vaud, Switzerland...
June 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28282504/soleus-atrophy-is-common-after-the-nonsurgical-treatment-of-acute-achilles-tendon-ruptures-a-randomized-clinical-trial-comparing-surgical-and-nonsurgical-functional-treatments
#19
Juuso Heikkinen, Iikka Lantto, Tapio Flinkkila, Pasi Ohtonen, Jaakko Niinimaki, Pertti Siira, Vesa Laine, Juhana Leppilahti
BACKGROUND: It remains controversial whether nonsurgical or surgical treatment provides better calf muscle strength recovery after an acute Achilles tendon rupture (ATR). Recent evidence has suggested that surgery might surpass nonsurgical treatment in restoring strength after an ATR. PURPOSE: To assess whether magnetic resonance imaging (MRI) findings could explain calf muscle strength deficits and the difference between nonsurgical and surgical treatments in restoring calf muscle strength...
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28251615/stiffness-mapping-of-lower-leg-muscles-during-passive-dorsiflexion
#20
Guillaume Le Sant, Antoine Nordez, Ricardo Andrade, François Hug, Sandro Freitas, Raphaël Gross
It is challenging to differentiate the mechanical properties of synergist muscles in vivo. Shear wave elastography can be used to quantify the shear modulus (i.e. an index of stiffness) of a specific muscle. This study assessed the passive behavior of lower leg muscles during passive dorsiflexion performed with the knee fully extended (experiment 1, n = 22) or with the knee flexed at 90° (experiment 2, n = 20). The shear modulus measurements were repeated twice during experiment 1 to assess the inter-day reliability...
May 2017: Journal of Anatomy
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