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https://www.readbyqxmd.com/read/28489964/specific-activation-of-plekhg2-induced-serum-response-element-dependent-gene-transcription-by-four-and-a-half-lim-domains-fhl-1-but-not-fhl2-or-fhl3
#1
Masashi Nishikawa, Katsuya Sato, Shun Nakano, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda
PLEKHG2 is a Gβγ- and Gαs-dependent guanine nucleotide exchange factor for Rac1 and Cdc42 small GTPases and has been shown to mediate signaling pathways such as those for actin cytoskeletal reorganization and serum response element (SRE)-dependent gene transcription. We have shown that the four-and-a-half LIM domains (FHL) 1 acts as a positive regulator of PLEKHG2. Here, we evaluated the other FHL family members and found that the FHL1A specifically regulate the PLEKHG2 activity. Moreover, FHL1A further enhanced Gβγ- and PLEKHG2-induced SRE-dependent gene transcription, whereas FHL1A partially restored the attenuated PLEKHG2-induced SRE-dependent gene transcription by Gαs...
May 10, 2017: Small GTPases
https://www.readbyqxmd.com/read/28488566/expanding-the-substrates-for-a-bacterial-hydrogenlyase-reaction
#2
Ciaran M Lamont, Ciarán L Kelly, Constanze Pinske, Grant Buchanan, Tracy Palmer, Frank Sargent
Escherichia coli produces enzymes dedicated to hydrogen metabolism under anaerobic conditions. In particular, a formate hydrogenlyase (FHL) enzyme is responsible for the majority of hydrogen gas produced under fermentative conditions. FHL comprises a formate dehydrogenase (encoded by fdhF) linked directly to [NiFe]-hydrogenase-3 (Hyd-3), and formate is the only natural substrate known for proton reduction by this hydrogenase. In this work, the possibility of engineering an alternative electron donor for hydrogen production has been explored...
May 10, 2017: Microbiology
https://www.readbyqxmd.com/read/28460573/biomechanical-analysis-of-suture-anchor-vs-tenodesis-screw-for-fhl-transfer
#3
Mark C Drakos, Michael Gott, Sydney C Karnovsky, Conor I Murphy, Bridget A DeSandis, Noah Chinitz, Daniel Grande, Nadeen Chahine
BACKGROUND: Chronic Achilles injury is often treated with flexor hallucis longus (FHL) tendon transfer to the calcaneus using 1 or 2 incisions. A single incision avoids the risks of extended dissections yet yields smaller grafts, which may limit fixation options. We investigated the required length of FHL autograft and biomechanical profiles for suture anchor and biotenodesis screw fixation. METHODS: Single-incision FHL transfer with suture anchor or biotenodesis screw fixation to the calcaneus was performed on 20 fresh cadaveric specimens...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28413452/ankle-and-toe-muscle-strength-characteristics-in-runners-with-a-history-of-medial-tibial-stress-syndrome
#4
Junya Saeki, Masatoshi Nakamura, Sayaka Nakao, Kosuke Fujita, Ko Yanase, Katsuyuki Morishita, Noriaki Ichihashi
BACKGROUND: A high proportion of flexor digitorum longus attachment is found at the posteromedial border of the tibia, which is the most common location of medial tibial stress syndrome (MTSS). Therefore, plantar flexion strength of the lesser toes could be related to MTSS; however, the relationship between MTSS and muscle strength of the hallux and lesser toes is not yet evaluated due to the lack of quantitative methods. This study investigated the muscle strength characteristics in runners with a history of MTSS by using a newly developed device to measure the muscle strength of the hallux, lesser toes, and ankle...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28399723/germline-heterozygous-variants-in-genes-associated-with-familial-hemophagocytic-lymphohistiocytosis-as-a-cause-of-increased-bleeding
#5
Marcus Fager Ferrari, Eva Leinoe, Maria Rossing, Eva Norström, Karin Strandberg, Tobias Steen Sejersen, Klaus Qvortrup, Eva Zetterberg
Familial hemophagocytic lymphohistiocytosis (FHL) is caused by biallelic variants in genes regulating granule secretion in cytotoxic lymphocytes. In FHL3-5, the affected genes UNC13D, STX11 and STXBP2 have further been shown to regulate the secretion of platelet granules, giving rise to compromised platelet function. Therefore, we aimed to investigate platelet degranulation in patients heterozygous for variants in UNC13D, STX11 and STXBP2. During the work-up of patients referred to the Coagulation Unit, Skåne University Hospital, Malmö, Sweden and the Department of Hematology, Rigshospitalet, Copenhagen, Denmark due to bleeding tendencies, 12 patients harboring heterozygous variants in UNC13D, STX11 or STXBP2 were identified using targeted whole exome sequencing...
April 11, 2017: Platelets
https://www.readbyqxmd.com/read/28394676/communication-of-contrast-in-the-flexor-hallucis-longus-tendon-with-other-pedal-tendons-at-the-master-knot-of-henry
#6
Sayed Ali, Nicole L Griffin, Whitney Ellis, Andrew J Meyr
It is important to have a full appreciation of lower-extremity anatomical relationships before undertaking diabetic foot surgery. We sought to evaluate the potential for communication of the flexor hallucis longus (FHL) tendon with other pedal tendons and plantar foot compartments at the master knot of Henry and to provide cadaveric images and computed tomographic (CT) scans of such communications. Computed tomography and subsequent anatomical dissection were performed on embalmed cadaveric limbs. Initially, 5 to 10 mL (1:4 dilution) of iohexol and normal saline was injected into the FHL sheath as it coursed between the two hallux sesamoids...
March 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28292571/health-literacy-and-quality-of-care-of-patients-with-diabetes-a-cross-sectional-analysis
#7
Emilie Zuercher, Ibrahima Dina Diatta, Bernard Burnand, Isabelle Peytremann-Bridevaux
BACKGROUND: Limited health literacy (HL) may lead to poor health outcomes and inappropriate healthcare use, particularly in patients with chronic diseases. We aimed to assess the association between functional HL (FHL) and quality of care, as measured by process- and outcome-of-care indicators, in patients with diabetes. METHODS: This cross-sectional study used data from the 2013 CoDiab-VD cohort follow-up, which included non-institutionalised adults with diabetes from canton of Vaud, Switzerland...
June 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28282504/soleus-atrophy-is-common-after-the-nonsurgical-treatment-of-acute-achilles-tendon-ruptures-a-randomized-clinical-trial-comparing-surgical-and-nonsurgical-functional-treatments
#8
Juuso Heikkinen, Iikka Lantto, Tapio Flinkkila, Pasi Ohtonen, Jaakko Niinimaki, Pertti Siira, Vesa Laine, Juhana Leppilahti
BACKGROUND: It remains controversial whether nonsurgical or surgical treatment provides better calf muscle strength recovery after an acute Achilles tendon rupture (ATR). Recent evidence has suggested that surgery might surpass nonsurgical treatment in restoring strength after an ATR. PURPOSE: To assess whether magnetic resonance imaging (MRI) findings could explain calf muscle strength deficits and the difference between nonsurgical and surgical treatments in restoring calf muscle strength...
May 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28251615/stiffness-mapping-of-lower-leg-muscles-during-passive-dorsiflexion
#9
Guillaume Le Sant, Antoine Nordez, Ricardo Andrade, François Hug, Sandro Freitas, Raphaël Gross
It is challenging to differentiate the mechanical properties of synergist muscles in vivo. Shear wave elastography can be used to quantify the shear modulus (i.e. an index of stiffness) of a specific muscle. This study assessed the passive behavior of lower leg muscles during passive dorsiflexion performed with the knee fully extended (experiment 1, n = 22) or with the knee flexed at 90° (experiment 2, n = 20). The shear modulus measurements were repeated twice during experiment 1 to assess the inter-day reliability...
March 2, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28226055/functional-health-literacy-and-knowledge-of-renal-patients-on-pre-dialytic-treatment
#10
Katarinne Lima Moraes, Virginia Visconde Brasil, Gabriela Ferreira de Oliveira, Jacqueline Andréia Bernardes Leão Cordeiro, Antonio Márcio Teodoro Cordeiro Silva, Rafaela Peres Boaventura, Denize Bouttelet Munari, Mônica Ribeiro Canhestro
Objective: to analyze the functional health literacy (FHL), i.e., understanding and knowledge about chronic renal disease of 60 patients in pre-dialytic treatment. Method: this is a cross-sectional study. FHL was measured by B-TOFHLA; and the knowledge, by questionnaire. Pearson correlation and Chi-square tests were carried out as well as linear regression models. Results: all respondents presented inadequate FHL, and most showed insufficient knowledge about the disease and treatment...
January 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28220191/anatomical-variations-of-flexor-hallucis-longus-tendon-increase-safety-in-hindfoot-endoscopy
#11
Jordi Vega, David Redó, Gabriela Savín, Francesc Malagelada, Miki Dalmau-Pastor
PURPOSE: The flexor hallucis longus (FHL) tendon is the main anatomical landmark during hindfoot endoscopy, and anatomical variations related to the FHL can pose a risk to the tibial nerve and posterior tibial vessels during hindfoot endoscopy. The aim of this study was to determine the distance between the FHL tendon and the tibial neurovascular bundle in the posterior ankle joint when an anatomical variant of the FHL is present. The hypothesis was that the shortest distance between the tibial neurovascular bundle and the FHL tendon in the working area of the hindfoot endoscopy is increased when an anatomical variant of the FHL is present...
February 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28168603/metschnikowia-persici-sp-nov-a-novel-protease-producing-yeast-species-from-china
#12
Chen Wang, Yang Liu, Tao-Tao Zhang, Cai-Ge Lu, Ya Liu, Dian-Peng Zhang, Wei-Cheng Liu
Three yeast strains, named as FHL-A, FHL-B, and FHL-C, were isolated from peach fruit surfaces collected from different regions in the North of China highly produced protease and were presented as single separate group in the genus Metschnikowia by sequence comparisons of 26S rRNA gene D1/D2 domain and internal transcribed spacer (ITS) region. BLASTn alignments on NCBI showed that the similarity of 26S rRNA gene sequences of the three strains to all sequences of other yeasts accessed into the GenBank/EMBL/DDBJ and other database was very low (≦93%)...
March 2017: Current Microbiology
https://www.readbyqxmd.com/read/28163203/the-high-variability-of-the-chiasma-plantare-and-the-long-flexor-tendons-anatomical-aspects-of-tendon-transfer-in-foot-surgery
#13
Bettina Pretterklieber
As tendon transfer of the flexor hallucis longus (FHL) and the flexor digitorum longus (FDL) is an established procedure, exact knowledge of the formation of the chiasma plantare is of great interest. Although the quadratus plantae (QP) appears to play a major role, it has been rarely addressed in previous studies. The aim of the present study was to reinvestigate the formation of the chiasma plantare and the composition of the long flexor tendons in order to clarify the inexact and partly contradictory descriptions published from 1865 onward...
February 3, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28156022/in-vivo-fascicle-behavior-of-the-flexor-hallucis-longus-muscle-at-different-walking-speeds
#14
A Péter, A Hegyi, T Finni, N J Cronin
Ankle plantar flexor muscles support and propel the body in the stance phase of locomotion. Besides the triceps surae, flexor hallucis longus muscle (FHL) may also contribute to this role, but very few in vivo studies have examined FHL function during walking. Here, we investigated FHL fascicle behavior at different walking speeds. Ten healthy males walked overground at three different speeds while FHL fascicle length changes were recorded with ultrasound and muscle activity was recorded with surface electromyography (EMG)...
February 3, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28108035/feline-hepatic-lipidosis
#15
REVIEW
Chiara Valtolina, Robert P Favier
Feline hepatic lipidosis (FHL) is a common and potentially fatal liver disorder. Although the pathophysiologic mechanisms of FHL remain elusive, there is an imbalance between the influx of fatty acids from peripheral fat stores into the liver, de novo liposynthesis, and the rate of hepatic oxidation and dispersal of hepatic TAG via excretion of very-low density lipoproteins. The diagnosis of FHL is based on anamnestic, clinical, and clinicopathologic findings, associated with diagnostic imaging of the liver, and cytology, or histological examination of liver biopsies...
May 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28102581/molecular-mechanisms-and-ecological-function-of-far-red-light-signalling
#16
REVIEW
David J Sheerin, Andreas Hiltbrunner
Land plants possess the ability to sense and respond to far-red light (700-760 nm), which serves as an important environmental cue. Due to the nature of far-red light, it is not absorbed by chlorophyll and thus is enriched in canopy shade, and will also penetrate deeper into soil than other visible wavelengths. Far-red light responses include regulation of seed germination, suppression of hypocotyl growth, induction of flowering, and accumulation of anthocyanins, which depend on one member of the phytochrome photoreceptor family, phytochrome A (phyA)...
January 19, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28031505/z-plasty-of-the-flexor-hallucis-longus-tendon-at-tarsal-tunnel-for-checkrein-deformity
#17
Jae Hoon Lee, Young Jun Kim, Jong Hun Baek, Dong Hee Kim
PURPOSES: To review the outcome of Z-plasty of the flexor hallucis longus (FHL) tendon at the tarsal tunnel for checkrein deformity in 8 patients. METHODS: Records of 6 males and 2 females aged 14 to 67 (mean, 39.5) years who underwent Z-plasty (lengthening) of the FHL tendon at the tarsal tunnel for checkrein deformity in the first and second toes by a single surgeon were reviewed. All patients had undergone 3 months of conservative treatment. The mean time from injury to surgical treatment was 8...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27936106/feasibility-of-10-minute-delayed-hepatocyte-phase-imaging-using-a-30%C3%A2-flip-angle-in-gd-eob-dtpa-enhanced-liver-mri-for-the-detection-of-hepatocellular-carcinoma-in-patients-with-chronic-hepatitis-or-cirrhosis
#18
Inhwan Jeon, Eun-Suk Cho, Joo Hee Kim, Dae Jung Kim, Jeong-Sik Yu, Jae-Joon Chung
OBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27914778/familial-haemophagocytosis-lymphohisticytosis-type-3-a-case-report
#19
F Kamoun, M Hsairi, V Grandin, S Ben Ameur, G De Saint Basile, M Hachicha
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare autosomal recessive disorder of immune regulation. Here, we report on a fatal case of type 3 FHL (FHL3) in a 45-day-old boy. Clinically, the infant presented with fever and hepatosplenomegaly. Biology showed pancytopenia, elevated ferritin, and decreased fibrinogen. Images of hemophagocytosis were found at the bone morrow examination. The diagnosis of FHL type 3 was made by the identification of homozygous mutation in the Munc13-4 gene (UNC13D) located in exon 20: 1822 del 12bp (V608fs)...
January 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27894453/usual-and-unusual-manifestations-of-familial-hemophagocytic-lymphohistiocytosis-and-langerhans-cell-histiocytosis
#20
REVIEW
Craig Erker, Paul Harker-Murray, Julie-An Talano
Familial hemophagocytic lymphohistiocytosis (FHL) and Langerhans cell histiocytosis (LCH) are histiocytic diseases that occur most commonly in young children. Improvements in recognition and treatment have been substantial for both diseases in the past decade, although early and late morbidity continue to be major concerns. These two diagnoses behave differently, although the clinical spectra for both diseases are diverse and can lead to confusion and delays in diagnosis and treatment. This article focuses on the clinical and genetic spectrum of FHL as well as the clinical and treatment variations of LCH...
February 2017: Pediatric Clinics of North America
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