keyword
https://read.qxmd.com/read/38491052/assessment-of-voltage-harmonics-impact-on-the-maximum-load-capacity-of-the-power-supply-transformer-for-the-lhcd-system
#1
JOURNAL ARTICLE
Hui Chen, Junjia Wang, Hejun Hu, Yiyun Huang
To study the influence of the voltage total harmonic distortion (THDV) and its spectrum on the harmonic loss factor (FHL ) and the maximum allowable load capacity ratio (Imax (pu)) for the transformer of the LHCD system, we use MATLAB software to model the LHCD system and study the winding loss and maximum allowed load capacity of the LHCD system transformer when the supply voltage source is sinusoidal and non-sinusoidal, respectively. The calculation is carried out by the method of IEEE standard C57.110 and the method of considering the skin effect...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38433405/strength-and-functional-outcomes-following-achilles-tendon-reconstruction-with-hamstring-tendon-autograft-augmentation
#2
JOURNAL ARTICLE
Stephanie K Eble, Oliver B Hansen, Saanchi K Kukadia, David J Cho, Prashanth Kumar, Andrea K Papson, Mark C Drakos
BACKGROUND: The proposed advantages of hamstring autograft reconstruction when compared to alternative procedures, such as flexor hallucis longus (FHL) transfer, V-Y lengthening, and allograft reconstruction, are improved healing and reproduction of normal tendon biomechanics and reduced morbidity within the foot and ankle. In this study, we examined the effect of Achilles tendon reconstruction using hamstring autografts on strength and functional outcomes. METHODS: Patients who underwent Achilles repair with a hamstring autograft for insertional or midsubstance tendinopathy, delayed diagnosis of rupture, or infection after primary repair were evaluated for inclusion...
March 3, 2024: Foot & Ankle International
https://read.qxmd.com/read/38415256/hlh-as-an-additional-warning-sign-of-inborn-errors-of-immunity-beyond-familial-hlh-in-children-a-systematic-review
#3
Silvia Ricci, Walter Maria Sarli, Lorenzo Lodi, Clementina Canessa, Francesca Lippi, Donata Dini, Marta Ferrari, Laura Pisano, Elena Sieni, Giuseppe Indolfi, Massimo Resti, Chiara Azzari
BACKGROUND: Hemophagocytic Lymphohistiocytosis (HLH) is a rare and life-threatening condition characterized by a severe impairment of the immune homeostasis. While Familial-HLH (FHL) is a known cause, the involvement of other Inborn Errors of Immunity (IEI) in pediatric-HLH remains understudied. OBJECTIVE: This systematic review aimed to assess the clinical features, triggers, laboratory data, treatment, and outcomes of pediatric HLH patients with IEI other than FHL (IEInotFHL), emphasizing the importance of accurate identification and management...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38404589/germline-defects-of-familial-hemophagocytic-lymphohistiocytosis-related-genes-presenting-as-adult-onset-peripheral-t-cell-lymphoma
#4
JOURNAL ARTICLE
Chong Wei, Danqing Zhao, Song Xue, Hao Cai, Congwei Jia, Daobin Zhou, Wei Zhang
Germline mutations in genes involved in perforin-granzyme-mediated cytotoxicity such as PRF1 , UNC13D , STX11 , and STXBP2 were known to cause familial hemophagocytic lymphohistiocytosis (FHL). In this study, we reported a unique group of 3 patients with germline mutations of UNC13D and STX11 genes and presented as adult-onset peripheral T-cell lymphoma (PTCL) with cytotoxic T-cell phenotype and atypical lymphoma presentations. CD107a degranulation assay and NK-cell activity analysis demonstrated impaired cytotoxic function of the NK/T-cells of the patients with FHL-related mutations...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38364674/quality-of-life-and-subjective-donor-site-morbidity-in-patients-after-a-free-fibula-flap
#5
JOURNAL ARTICLE
K Klaassen, K E Kofman, D C Broekstra, M W Stenekes
INTRODUCTION: We evaluated the subjective donor-site morbidity and quality of life in patients with a free fibula flap (FFF) reconstruction in terms of self-reported symptoms, function and quality of life, and we compared inclusion vs. exclusion of the flexor hallucis longus (FHL) muscle in the graft, primary wound closure vs. skin graft and the occurrence vs. absence of donor-site complications. METHODS: In this cross-sectional study, patients who underwent a mandibula or maxilla reconstruction with a FFF between 2011 and 2021, were included...
February 2, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38344182/functional-dissection-of-phytochrome-a-in-plants
#6
REVIEW
Yuqi Lei, Qi Ma, Yihao Zhang, Jilian Li, Xinzhu Ning, Yichen Wang, Xiaoyang Ge, Hang Zhao, Hai Lin
Plants lack behavioral responses to avoid dramatic environmental changes associated with the annual seasons. For survival, they have evolved complex sensory systems to sense fluctuations in light and optimize their architecture in response to changes in these cues. Phytochrome A (phyA) was initially identified as a photoreceptor that senses far-red light signals. It was then identified as playing a central role in promoting hypocotyl growth, fiber development, and flowering time in a variety of plants including Arabidopsis, rice, soybean and cotton...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38337799/the-relationship-between-types-of-os-trigonum-and-findings-of-conventional-ankle-magnetic-resonance-imaging-a-study-based-on-three-dimensional-magnetic-resonance-imaging
#7
JOURNAL ARTICLE
Kyu-Hong Lee, Ro-Woon Lee, Yeo-Ju Kim
This study aimed to investigate the dimensions and types of the os trigonum and evaluate their relationship with various pathologic conditions on the posterior ankle using ankle MRI images. A total of 124 non-contrast-enhanced ankle and foot MR images of 123 consecutive patients were included in this retrospective study. The images were presented randomly, and they contained no patient information. The MR images were retrospectively and independently reviewed by two reviewers with a fellowship-trained musculoskeletal radiologist...
January 28, 2024: Diagnostics
https://read.qxmd.com/read/38318167/erratum-approaching-hemophagocytic-lymphohistiocytosis
#8
(no author information available yet)
[This corrects the article DOI: 10.3389/fimmu.2023.1210041.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38307245/role-of-the-escherichia-coli-foca-and-focb-formate-channels-in-controlling-proton-potassium-fluxes-and-hydrogen-production-during-osmotic-stress-in-energy-limited-stationary-phase-fermenting-cells
#9
JOURNAL ARTICLE
A Babayan, A Vassilian, A Poladyan, K Trchounian
Escherichia coli FocA and FocB formate channels export formate or import it for further disproportionation by the formate hydrogenlyase (FHL) complex to H2 and CO2 . Here, we show that under pH and osmotic stress FocA and FocB play important roles in regulating proton and potassium fluxes and couple this with H2 production in stationary-phase cells. Using whole-cell assays with glucose as electron donor, a focB mutant showed a 50 % decrease in VH2 , while N'N'-dicyclohexylcarbodiimide (DCCD) treatment of osmotically stressed cells underlined the role of FO F1 ATPase in H2 production...
January 31, 2024: Biochimie
https://read.qxmd.com/read/38306418/precise-crispr-cas9-gene-repair-in-autologous-memory-t-cells-to-treat-familial-hemophagocytic-lymphohistiocytosis
#10
JOURNAL ARTICLE
Xun Li, Tristan Wirtz, Timm Weber, Mikhail Lebedin, Elijah D Lowenstein, Thomas Sommermann, Andreas Zach, Tomoharu Yasuda, Kathrin de la Rosa, Van Trung Chu, Johannes H Schulte, Ingo Müller, Christine Kocks, Klaus Rajewsky
Familial hemophagocytic lymphohistiocytosis (FHL) is an inherited, often fatal immune deficiency characterized by severe systemic hyperinflammation. Although allogeneic bone marrow transplantation can be curative, more effective therapies are urgently needed. FHL is caused by inactivating mutations in proteins that regulate cellular immunity. Here, we used an adeno-associated virus-based CRISPR-Cas9 system with an inhibitor of nonhomologous end joining to repair such mutations in potentially long-lived T cells ex vivo...
February 2, 2024: Science Immunology
https://read.qxmd.com/read/38268767/chronic-achilles-tendon-avulsion-repair-central-third-fascia-slide-technique-with-flexor-hallucis-longus-transfer
#11
JOURNAL ARTICLE
Logan J Roebke, Paul M Alvarez, Christian Curatolo, Reid Palumbo, Kevin D Martin
BACKGROUND: Chronic Achilles tendon defects are commonly associated with substantial impairment in gait and push-off strength, leading to decreased function1 . These injuries cause a unique surgical dilemma, with no consensus surgical reconstruction technique for >6-cm gaps3 . There are a multitude of surgical reconstruction techniques that rely on gap size as a determinant for preoperative planning1,2 . The present article describes a technique for chronic Achilles tendon defects of >6 cm...
2024: JBJS Essential Surgical Techniques
https://read.qxmd.com/read/38245696/injury-of-flexor-halluics-longus-tendon-in-amateur-marathon-runners-results-in-abnormal-plantar-pressure-distribution-observational-study
#12
JOURNAL ARTICLE
Jianan Chen, Ping Zhang, Liting Hou, Hailun Bao, Junfei Li, Jian Zhao
OBJECTIVE: To analyze the changes of plantar pressure in amateur marathon runners with flexor halluics longus (FHL) tendon injury using the Medtrack-Gait plantar pressure measurement system, and to explore whether the plantar pressure data can be used as an index for the diagnosis of injury. METHODS: A total of 39 healthy amateur marathon runners without any ankle joint symptoms were recruited. Dynamic and static plantar pressure data were measured using the pressure plate of Medtrack-Gait...
January 20, 2024: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/38212754/detection-of-a-novel-gross-deletion-in-the-unc13d-gene-ends-the-diagnostic-odyssey-for-a-family-with-familial-hemophagocytic-lymphohistiocytosis-3
#13
JOURNAL ARTICLE
Chinmayee B Nagaraj, Diana S Brightman, Hannah Rea, Emily Wakefield, Nina V G Harkavy, Lisa Dyer, Wenying Zhang
BACKGROUND: Familial hemophagocytic lymphohistiocytosis (FHL) is an immunological disorder characterized by overactivation of macrophages and T lymphocytes. This autosomal recessive condition has been characterized into multiple types depending on the genetic etiology. FHL type 3 is associated with bi-allelic pathogenic variants in the UNC13D gene. CASE PRESENTATION: We present a 12-year diagnostic odyssey for a family with FHL that signifies the advances of FHL genetic testing in a clinical genetic diagnostic laboratory setting...
January 11, 2024: BMC Pediatrics
https://read.qxmd.com/read/38183876/unraveling-the-role-of-the-fhl-family-in-cardiac-diseases-mechanisms-implications-and-future-directions
#14
REVIEW
Tongbing Qi, Jingwen Zhang, Kexin Zhang, Wenqiang Zhang, Yixin Song, Kexin Lian, Chengxia Kan, Fang Han, Ningning Hou, Xiaodong Sun
Heart diseases are a major cause of morbidity and mortality worldwide. Understanding the molecular mechanisms underlying these diseases is essential for the development of effective diagnostic and therapeutic strategies. The FHL family consists of five members: FHL1, FHL2, FHL3, FHL4, and FHL5/Act. These members exhibit different expression patterns in various tissues including the heart. FHL family proteins are implicated in cardiac remodeling, regulation of metabolic enzymes, and cardiac biomechanical stress perception...
January 3, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38124260/treatment-of-dynamic-claw-toe-deformity-through-lengthening-of-the-flexor-tendons-of-the-hallux-and-toes-at-the-midfoot-level
#15
JOURNAL ARTICLE
Henrique Mansur, Phelipe Pinheiro Alves Lucas, Daniel Augusto Maranho
The claw toe deformity is characterized by the flexion of interphalangeal joints (IPJs) with hyperextension of the metatarsophalangeal (MTP) joint. It can be flexible and reducible or rigid and irreducible, or dynamic. The most common cause of dynamic claw toes is a neurological disorder, like sequelae of an ischemic contracture of the muscle belly after a compartment syndrome. Most of the surgical techniques require multiple procedures and may be associated with complications such as toe stiffness, persisting metatarsalgia, and toe malalignment...
December 20, 2023: Foot & Ankle Specialist
https://read.qxmd.com/read/38107357/flexor-hallucis-longus-transfer-and-v-y-plasty-an-effective-treatment-modality-for-chronic-achilles-rupture-a-case-series
#16
JOURNAL ARTICLE
R H Rashid, R Ali, M Zahid, M Ali, T Ahmad
INTRODUCTION: To assess outcomes of FHL transfer and V-Y plasty for chronic Achilles rupture due to insertional Achilles tendinopathy. MATERIALS AND METHODS: A case series of 12 patients was conducted between 1st January 2017 and 31st December 2018. The patients had short flexor hallucis longus tendon transfer with gastrocnemius lengthening by V-Y plasty for Achilles tendon rupture. Patients were allowed full weight bearing at six weeks post-operatively, and were followed up at three months and six months post-operatively, when the range of motion of the ankle was examined, and the outcome was assessed using the EFAS score...
November 2023: Malaysian Orthopaedic Journal
https://read.qxmd.com/read/38084697/a-case-of-fetal-familial-hemophagocytic-lymphohistiocytosis-type-5-caused-by-stxbp2-gene-mutation
#17
Chunyan Fu, Rong Wen, Jiyong Zhou, Jingfei Hu, Xiuxiang Liu
BACKGROUND: Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is a rare hyper-inflammatory syndrome caused by mutations in STXBP2. Most cases present at 2 - 6 months of age, and FHL-5 is extremely rare in neonates. METHODS: Appropriate laboratory tests, abdominal ultrasonography and whole exome sequencing were carried out. Respiratory support, antibiotics, and transfusion of blood products were done. RESULTS: Laboratory tests revealed metabolic acidosis, thrombocytopenia, mild anemia, and low fibrinogen level...
December 1, 2023: Clinical Laboratory
https://read.qxmd.com/read/38035126/safety-and-tolerability-of-onabotulinumtoxina-in-the-treatment-of-upper-facial-lines-from-global-registration-studies-in-5298-participants-a-meta-analysis
#18
JOURNAL ARTICLE
Mitchell F Brin, Koen De Boulle, Steven Liew, Alastair Carruthers, Jean Carruthers, Alexander Rivkin, Yan Wu, Makoto Kawashima, Irina Yushmanova, Terry I Boodhoo, Elisabeth Lee
BACKGROUND: Since its discovery as a facial aesthetic treatment >30 years ago, onabotulinumtoxinA has received worldwide approval for dynamic upper facial line treatment. OBJECTIVE: Meta-analysis examining the safety of onabotulinumtoxinA for treatment of glabellar lines (GL), crow's feet lines (CFL), and forehead lines (FHL). METHODS: Participants ( N  = 5298) with moderate to severe GL, CFL, or FHL at maximum contraction received onabotulinumtoxinA or placebo in 1 of 18 registration studies (14 double-blind, placebo-controlled [DBPC]; 1 double-blind; 3 open-label)...
March 2024: JAAD international
https://read.qxmd.com/read/38024054/foreign-body-reaction-following-achilles-tendon-reconstruction-with-the-ligament-advanced-reconstructive-system-patient-outcomes-and-clinical-course
#19
Niall Fitzpatrick, Theenesh Balakrishnan, Anand Pillai
The Ligament Advanced Reinforcement System (LARS) is a common choice for ligament reconstruction in the lower limb due to its good functional and quality of life (QoL)-related outcomes. It is commonly used for Achilles tendon repair following a rupture. While it facilitates tissue ingrowth and boasts good biocompatibility, we report on multiple cases whereby foreign body reactions have led to the growth of granulomas requiring surgical excision and Flexor Hallucis Longus (FHL) transfer. Following these cases, patients have been shown to have excellent functional and QoL-related outcomes using the Manchester Oxford Foot Questionnaire (MOX-FQ) and Foot and Ankle Ability Measure (FAAM)...
November 2023: Curēus
https://read.qxmd.com/read/37993498/the-compensatory-hypertrophy-of-transferred-flexor-hallucis-longus-tendon-for-insertional-achilles-tendinopathy-a-retrospective-mri-study
#20
JOURNAL ARTICLE
Wei-Jen Liao, Shih-Chieh Tang, Han-Ting Shih, Kuo-Chih Su, Kao-Chang Tu, Shun-Ping Wang
Flexor hallucis longus (FHL) transfer is an effective surgery in treating insertional Achilles tendinopathy (IAT). However, limited data exist regarding the post-surgery changes in the transferred FHL. The study aimed to compare the sequential changes and hypertrophy of FHL after isolated FHL transfer (FHLT). We retrospectively enrolled patients who underwent isolated FHLT for insertional Achilles pathology from 2015 to 2020 and divided them into two groups based on whether reattachment of the residue Achilles stump to the FHL was performed or not...
November 22, 2023: Scientific Reports
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