keyword
https://read.qxmd.com/read/38395404/role-of-diacylglycerol-o-acyltransferase-1-dgat1-in-lipolysis-and-autophagy-of-adipose-tissue-from-ketotic-dairy-cows
#21
JOURNAL ARTICLE
Qiushi Xu, Yunhui Fan, John Mauck, Juan J Loor, Xudong Sun, Hongdou Jia, Xinwei Li, Chuang Xu
High-yielding dairy cows in early lactation often encounter difficulties in meeting the energy requirements essential for maintaining milk production. This is primarily attributed to insufficient dry matter intake, which consequently leads to sustained lipolysis of adipose tissue. Fatty acids released by lipolysis can disrupt metabolic homeostasis. Autophagy, an adaptive response to intracellular environmental changes, is considered a crucial mechanism for regulating lipid metabolism and maintaining a proper cellular energy status...
February 21, 2024: Journal of Dairy Science
https://read.qxmd.com/read/38366688/cacao-procyanidins-induced-lifespan-extension-in-caenorhabditis-elegans-in-a-nervous-system-and-camkii-dependent-manner
#22
JOURNAL ARTICLE
Keiya Ohmine, Yuki Morinaga, Sarina Kobayashi, Aika Matsubara, Kaito Sadanaga, Shuhei Tohtani, Hideaki Saeki, Hiroto Horiuchi, Yuta Fujikawa, Koichiro Sumi, Midori Natsume, Hideshi Inoue
Procyanidins are gaining attention due to their potential health benefits. We found that cacao liquor procyanidin (CLPr) from Theobroma cacao seeds increased the lifespan of Caenorhabditis elegans, a representative model organism for aging studies. The genetic dependence of the lifespan-extending effect of CLPr was consistent with that of blueberry procyanidin, which is dependent on unc-43, osr-1, sek-1, and mev-1, but not on daf-16, sir-2.1, or skn-1. The lifespan-extending effect of CLPr was inhibited by neuron-specific RNA interference (RNAi) targeting unc-43 and pmk-1, and in worms with loss-of-function mutations in the odr-3, odr-1, or tax-4 genes, which are essential in sensory neurons, including AWC neurons...
February 16, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38366576/perceived-transition-readiness-among-adolescents-and-young-adults-with-neurofibromatosis-type-1-and-plexiform-neurofibromas-a-cross-sectional-descriptive-study
#23
JOURNAL ARTICLE
Atara Siegel, Robin Lockridge, Kari L Struemph, Mary Anne Toledo-Tamula, Paige Little, Pamela L Wolters, Anne Dufek, Cecilia Tibery, Melissa Baker, Brigitte C Wideman, Staci Martin
OBJECTIVES: Neurofibromatosis type 1 (NF1) is a genetic cancer predisposition syndrome that can impact multiple organ systems and is associated with plexiform neurofibroma tumors, requiring care from birth through adulthood. Adolescents and young adults (AYAs) with NF1 face several barriers to transition from pediatric to adult care. This cross-sectional study aimed to assess transition readiness in this population and to evaluate relationships between specific NF1 symptoms and transition readiness...
February 15, 2024: Journal of Pediatric Psychology
https://read.qxmd.com/read/38363837/structural-insights-into-the-formation-of-repulsive-netrin-guidance-complexes
#24
JOURNAL ARTICLE
Jessica M Priest, Ev L Nichols, Robert G Smock, Jesse B Hopkins, Juan L Mendoza, Rob Meijers, Kang Shen, Engin Özkan
Netrins dictate attractive and repulsive responses during axon growth and cell migration, where the presence of the receptor Uncoordinated-5 (UNC-5) on target cells results in repulsion. Here, we showed that UNC-5 is a heparin-binding protein, determined its structure bound to a heparin fragment, and could modulate UNC-5-heparin affinity using a directed evolution platform or structure-based rational design. We demonstrated that UNC-5 and UNC-6/netrin form a large, stable, and rigid complex in the presence of heparin, and heparin and UNC-5 exclude the attractive UNC-40/DCC receptor from binding to UNC-6/netrin to a large extent...
February 16, 2024: Science Advances
https://read.qxmd.com/read/38361280/did-mitophagy-follow-the-origin-of-mitochondria
#25
REVIEW
Mauro Degli Esposti
Mitophagy is the process of selective autophagy that removes superfluous and dysfunctional mitochondria. Mitophagy was first characterized in mammalian cells and is now recognized to follow several pathways including basal forms in specific organs. Mitophagy pathways are regulated by multiple, often interconnected factors. The present review aims to streamline this complexity and evaluate common elements that may define the evolutionary origin of mitophagy. Key issues surrounding mitophagy signaling at the mitochondrial surface may fundamentally derive from mitochondrial membrane dynamics...
February 15, 2024: Autophagy
https://read.qxmd.com/read/38360995/let-381-foxf-and-its-target-unc-30-pitx2-specify-and-maintain-the-molecular-identity-of-c-elegans-mesodermal-glia-that-regulate-motor-behavior
#26
JOURNAL ARTICLE
Nikolaos Stefanakis, Jessica Jiang, Yupu Liang, Shai Shaham
While most glial cell types in the central nervous system (CNS) arise from neuroectodermal progenitors, some, like microglia, are mesodermally derived. To understand mesodermal glia development and function, we investigated C. elegans GLR glia, which envelop the brain neuropil and separate it from the circulatory system cavity. Transcriptome analysis shows that GLR glia combine astrocytic and endothelial characteristics, which are relegated to separate cell types in vertebrates. Combined fate acquisition is orchestrated by LET-381/FoxF, a fate-specification/maintenance transcription factor also expressed in glia and endothelia of other animals...
February 15, 2024: EMBO Journal
https://read.qxmd.com/read/38355608/icariin-exerts-anti-tumor-activity-by-inducing-autophagy-via-ampk-mtor-ulk1-pathway-in-triple-negative-breast-cancer
#27
JOURNAL ARTICLE
Mei Zhao, Panling Xu, Wenjing Shi, Juan Wang, Ting Wang, Ping Li
BACKGROUND: Breast cancer is the most prevalent female tumor, of which triple-negative breast cancer (TNBC) accounts for about 15%. Characterized by its aggressive nature and limited treatment options, TNBC currently stands as a significant clinical challenge. This study aimed to investigate the effects of icariin (ICA) on TNBC and explore the underlying molecular mechanism. METHODS: Cell viability was assessed using CCK-8 assay, whereas the impact of ICA on cell proliferation was determined using colony formation assay and detection of proliferating cell nuclear antigen protein...
February 14, 2024: Cancer Cell International
https://read.qxmd.com/read/38345070/tiam-1-regulates-polarized-protrusions-during-dorsal-intercalation-in-the-c-elegans-embryo-through-both-its-gef-and-n-terminal-domains
#28
JOURNAL ARTICLE
Yuyun Zhu, Zoe Tesone, Minyi Tan, Jeff Hardin
Mediolateral cell intercalation is a morphogenetic strategy used throughout animal development to reshape tissues. Dorsal intercalation in the C. elegans embryo involves the mediolateral intercalation of two rows of dorsal epidermal cells to create a single row that straddles the dorsal midline, and so is a simple model to study cell intercalation. Polarized protrusive activity during dorsal intercalation requires the C. elegans Rac and RhoG orthologs CED-10 and MIG-2, but how these GTPases are regulated during intercalation has not been thoroughly investigated...
February 12, 2024: Journal of Cell Science
https://read.qxmd.com/read/38345047/robot-assisted-ureteric-reconstructive-surgeries-for-benign-diseases-initial-single-center-experience-with-point-of-technique
#29
JOURNAL ARTICLE
Nikita Shrivastava, Priyank Bhargava, Pritesh Jain, Gautam Ram Choudhary, Rahul Jena, Mahendra Singh, Shivcharan Navriya, Vijay Kumar Sarma Madduri, Deepak Prakash Bhirud, Arjun Singh Sandhu
INTRODUCTION: We present our initial experience with robot-assisted reconstructive surgeries with the Da Vinci Xi robotic system for benign ureteric pathologies. MATERIALS AND METHODS: This is a retrospective review of prospectively collected data of patients who underwent robot-assisted reconstructive procedures for benign diseases of the ureter at our department from April 2018 to November 2022. Demographic and perioperative details were recorded. Patients were followed up and surgical success was evaluated on the basis of symptomatic, functional, and radiological improvement...
February 12, 2024: Urologia
https://read.qxmd.com/read/38343619/the-association-between-long-covid-symptomology-perceived-symptom-burden-and-mental-health-in-covid-19-patients-in-shijiazhuang-china-a-population-based-health-survey
#30
JOURNAL ARTICLE
Yufei Li, Lawrence T Lam, Ying Xiao, Zhengqi Qiu, Yanming Zhang
BACKGROUND: Long-COVID (LC) refers to post-acute COVID-19 symptoms that can last for months or longer after the initial infection, affecting the physical health of infected patients. This study aims to investigate the association between the symptomology of LC and the mental health of patients in China. It also aims to examine the relationship between the perceived symptom burden and mental health of these patients. METHODS: A population-based stratified cluster sample was recruited, using a standard sampling procedure, from a prefecture-level city in Northern China...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38330885/stride-to-stride-fluctuations-and-temporal-patterns-of-muscle-activity-exhibit-similar-responses-during-walking-to-variable-visual-cues
#31
JOURNAL ARTICLE
João R Vaz, Nelson Cortes, João Sá Gomes, Sofia Jordão, Nick Stergiou
Incorporating variability within gait retraining approaches has been proposed and shown to lead to positive changes. Specifically, submitting the individuals to walk in synchrony to cues that are temporally organized with a fractal-like patterns, promotes changes at the stride-to-stride fluctuations closer to those typically find in young adults. However, there is still a need to understand the underlying neuromuscular mechanisms associated to such improvement. Thus, this study aimed to investigate whether changes in the temporal structure of the variability in gait patterns are accompanied by changes in muscle activity patterns...
February 3, 2024: Journal of Biomechanics
https://read.qxmd.com/read/38326722/exosome-transmitted-mir-224-5p-promotes-colorectal-cancer-cell-proliferation-via-targeting-ulk2-in-p53-dependent-manner
#32
JOURNAL ARTICLE
Le Mei Yang, Qi Zheng, Xiao Jia Liu, Xian Xian Li, Lim Veronica, Qi Chen, Zhong Hua Zhao, Shu Yang Wang
OBJECTIVE: To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer (CRC). METHODS: The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR, respectively. Dual-luciferase reporter gene assay was used to determine the target gene of miR-224-5p. The protein expressions of p53 and unc-51 like kinase 2 (ULK2) in CRC cells were detected by western blot. Flow cytometry was used to detect cell cycle and apoptosis...
January 20, 2024: Biomedical and Environmental Sciences: BES
https://read.qxmd.com/read/38324636/drak2-suppresses-autophagy-by-phosphorylating-ulk1-at-ser-56-to-diminish-pancreatic-%C3%AE-cell-function-upon-overnutrition
#33
JOURNAL ARTICLE
Yuting Lu, Junyu Xu, Yufeng Li, Ruoran Wang, Chengqiu Dai, Bingqian Zhang, Xinwen Zhang, Lei Xu, Yunhua Tao, Ming Han, Ren Guo, Qingqian Wu, Linshi Wu, Zhuoxian Meng, Minjia Tan, Jingya Li
Impeded autophagy can impair pancreatic β cell function by causing apoptosis, of which DAP-related apoptosis-inducing kinase-2 (DRAK2) is a critical regulator. Here, we identified a marked up-regulation of DRAK2 in pancreatic tissue across humans, macaques, and mice with type 2 diabetes (T2D). Further studies in mice showed that conditional knockout (cKO) of DRAK2 in pancreatic β cells protected β cell function against high-fat diet feeding along with sustained autophagy and mitochondrial function...
February 7, 2024: Science Translational Medicine
https://read.qxmd.com/read/38321366/sodium-fluoride-induced-autophagy-of-ameloblast-like-cells-via-the-p-ulk1-atg13-lc3b-pathway-in%C3%A2-vitro
#34
JOURNAL ARTICLE
S Yang, D Song, R Wang, M Liu, T Tan, Y Wang, Q Xie, L Wang
OBJECTIVE: To investigate the effects of sodium fluoride on the ameloblast and reveal the mechanism of dental fluorosis. MATERIALS AND METHODS: Mouse ameloblast-like cell line (ALC) cells were treated with various concentrations of NaF, and subjected to Incucyte, fluorescence immunoassay, transmission electron microscopy, reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blot for autophagy examination, alkaline phosphatase and alizarin red staining for mineralization after osteogenic induction...
February 6, 2024: Oral Diseases
https://read.qxmd.com/read/38311233/physiological-functions-of-ulk1-2
#35
REVIEW
Gautam Pareek, Mondira Kundu
UNC-51-like kinases 1 and 2 (ULK1/2) are serine/threonine kinases that are best known for their evolutionarily conserved role in the autophagy pathway. Upon sensing the nutrient status of a cell, ULK1/2 integrate signals from upstream cellular energy sensors such as mTOR and AMPK and relay them to the downstream components of the autophagy machinery. ULK1/2 also play indispensable roles in the selective autophagy pathway, removing damaged mitochondria, invading pathogens, and toxic protein aggregates. Additional functions of ULK1/2 have emerged beyond autophagy, including roles in protein trafficking, RNP granule dynamics, and signaling events impacting innate immunity, axon guidance, cellular homeostasis, and cell fate...
February 2, 2024: Journal of Molecular Biology
https://read.qxmd.com/read/38305800/identifying-novel-chemical-related-susceptibility-genes-for-five-psychiatric-disorders-through-integrating-genome-wide-association-study-and-tissue-specific-3-aqtl-annotation-datasets
#36
JOURNAL ARTICLE
Sirong Shi, Huijie Zhang, Xiaoge Chu, Qingqing Cai, Dan He, Xiaoyue Qin, Wenming Wei, Na Zhang, Yijing Zhao, Yumeng Jia, Feng Zhang, Yan Wen
The establishment of 3'aQTLs comprehensive database provides an opportunity to help explore the functional interpretation from the genome-wide association study (GWAS) data of psychiatric disorders. In this study, we aim to search novel susceptibility genes, pathways, and related chemicals of five psychiatric disorders via GWAS and 3'aQTLs datasets. The GWAS datasets of five psychiatric disorders were collected from the open platform of Psychiatric Genomics Consortium (PGC, https://www.med.unc.edu/pgc/ ) and iPSYCH ( https://ipsych...
February 2, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38296961/mitochondrial-protein-c15orf48-is-a-stress-independent-inducer-of-autophagy-that-regulates-oxidative-stress-and-autoimmunity
#37
JOURNAL ARTICLE
Yuki Takakura, Moeka Machida, Natsumi Terada, Yuka Katsumi, Seika Kawamura, Kenta Horie, Maki Miyauchi, Tatsuya Ishikawa, Nobuko Akiyama, Takao Seki, Takahisa Miyao, Mio Hayama, Rin Endo, Hiroto Ishii, Yuya Maruyama, Naho Hagiwara, Tetsuya J Kobayashi, Naoto Yamaguchi, Hiroyuki Takano, Taishin Akiyama, Noritaka Yamaguchi
Autophagy is primarily activated by cellular stress, such as starvation or mitochondrial damage. However, stress-independent autophagy is activated by unclear mechanisms in several cell types, such as thymic epithelial cells (TECs). Here we report that the mitochondrial protein, C15ORF48, is a critical inducer of stress-independent autophagy. Mechanistically, C15ORF48 reduces the mitochondrial membrane potential and lowers intracellular ATP levels, thereby activating AMP-activated protein kinase and its downstream Unc-51-like kinase 1...
February 1, 2024: Nature Communications
https://read.qxmd.com/read/38294696/effects-of-interleukin-15-on-autophagy-regulation-in-the-skeletal-muscle-of-mice
#38
JOURNAL ARTICLE
Minoru Tanaka, Ken Sugimoto, Hiroshi Akasaka, Shino Yoshida, Toshimasa Takahashi, Taku Fujimoto, Keyu Xie, Yukiko Yasunobe, Koichi Yamamoto, Takumi Hirabayashi, Ryosuke Nakanishi, Hidemi Fujino, Hiromi Rakugi
This study aimed to evaluate the role of skeletal muscle-derived interleukin (IL)-15 in the regulation of skeletal muscle autophagy using IL-15 knockout (KO) and transgenic (TG) mice. Male C57BL/6 wild type (WT), IL-15 KO, and IL-15 TG mice were used in this study. Changes in muscle mass, forelimb grip strength, succinate dehydrogenase (SDH) activity, gene and protein expression levels of major regulators and indicators of autophagy, comprehensive gene expression, and DNA methylation in the gastrocnemius muscle were analyzed...
January 31, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38286802/regulation-of-ulk1-by-wtap-igf2bp3-axis-enhances-mitophagy-and-progression-in-epithelial-ovarian-cancer
#39
JOURNAL ARTICLE
Jiao Wang, Fei Zheng, Dandan Wang, Qing Yang
There is a pressing need for innovative therapeutic strategies for patients with epithelial ovarian cancer (EOC). Previous studies have shown that UNC-51-like kinase 1 (ULK1), a serine/threonine kinase, is crucial in regulating cellular autophagy and mitophagy across various tumor types. However, the clinical implications, biological functions, and potential mechanisms of ULK1 in EOC remain poorly understood. This study demonstrates that ULK1 expression is upregulated in EOC tissue samples and EOC cell lines, with increased ULK1 expression correlating with poor prognosis...
January 29, 2024: Cell Death & Disease
https://read.qxmd.com/read/38273760/curcumol-enhances-the-antitumor-effect-of-lenvatinib-on-hepatocellular-carcinoma-cells
#40
JOURNAL ARTICLE
ZhaoLi Wu, Jia Wang
BACKGROUND: Lenvatinib is an important molecular target drug for the treatment of advanced hepatocellular carcinoma (HCC). However, the application of molecular targeted therapies for HCC also faces some challenges. Cumulative evidence has also shown that curcumol is a potential anti-HCC drug. Curcumol can be used as a chemosensitizer to enhance the antitumor effect of chemotherapeutic drugs. The purpose of our study is to explore the effect of curcumol combined with lenvatinib on HCC...
January 2024: Discovery Medicine
keyword
keyword
100005
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.