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https://www.readbyqxmd.com/read/27723231/the-importance-of-provision-and-utilization-of-supervisor-support
#1
Alec Munc, Kevin Eschleman, Janet Donnelly
Three cross-sectional studies examined the benefits of provision of supervisor support while controlling for subordinate utilization of supervisor support. Data were collected from workers in a subordinate role (Study 1 N = 355; Study 2 N = 229; Study 3 N = 109). Consistent with expectations, provision of supervisor support consistently explained unique variance in affective job criteria while controlling for utilization of supervisor support. The results indicate that supervisors should acknowledge that their workers experience the affective benefits of supervisor support even if the workers do not consistently use the support provided...
October 10, 2016: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/27630671/repair-of-traumatic-plasmalemmal-damage-to-neurons-and-other-eukaryotic-cells
#2
REVIEW
George D Bittner, Christopher S Spaeth, Andrew D Poon, Zachary S Burgess, Christopher H McGill
The repair (sealing) of plasmalemmal damage, consisting of small holes to complete transections, is critical for cell survival, especially for neurons that rarely regenerate cell bodies. We first describe and evaluate different measures of cell sealing. Some measures, including morphological/ultra-structural observations, membrane potential, and input resistance, provide very ambiguous assessments of plasmalemmal sealing. In contrast, measures of ionic current flow and dye barriers can, if appropriately used, provide more accurate assessments...
July 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27630261/the-interaction-of-munc-18-p67-with-the-p10-domain-of-p35-protects-in-vivo-cdk5-p35-activity-from-inhibition-by-tfp5-a-peptide-derived-from-p35
#3
Niranjana D Amin, Yali Zheng, Binukumar Bk, Varsha Shukla, Susan Skuntz, Philip Grant, Joseph Steiner, Manju Bhaskar, Harish C Pant
In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, that inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in AD model mice, the peptide specifically inhibits the Cdk5/p25 complex and not the endogenous Cdk5/p35. To account for the selective inhibition of Cdk5/p25 activity, we propose that the "p10" N-terminal domain of p35, absent in p25, spares Cdk5/p35 because p10 binds to macromolecules (e...
September 14, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27558849/distinct-roles-of-the-two-vps33-proteins-in-the-endolysosomal-system-in-caenorhabditis-elegans
#4
Keiko Gengyo-Ando, Eriko Kage-Nakadai, Sawako Yoshina, Muneyoshi Otori, Yuko Kagawa-Nagamura, Junichi Nakai, Shohei Mitani
Sec1/Munc-18 (SM) family proteins are essential regulators in intracellular transport in eukaryotic cells. The SM protein Vps33 functions as a core subunit of two tethering complexes, class C core vacuole/endosome tethering (CORVET) and homotypic fusion and vacuole protein sorting (HOPS) in the endocytic pathway in yeast. Metazoan cells possess two Vps33 proteins, VPS33A and VPS33B, but their precise roles remain unknown. Here, we present a comparative analysis of Caenorhabditis elegans null mutants for these proteins...
August 25, 2016: Traffic
https://www.readbyqxmd.com/read/27361632/injury-rates-and-types-at-a-small-recreational-ski-area-in-the-upper-midwest-3063-board-128-june-3-3-30-pm-5-00-pm
#5
James A White, Darren L DeNeui, Jason C Dorman, Thayne A Munce
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27360154/head-impact-exposure-in-youth-football-during-different-practice-activities-1011-board-327-june-1-3-30-pm-5-00-pm
#6
Thayne A Munce, Jason C Dorman, Verle D Valentine
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27324898/protein-profile-and-morphological-alterations-in-penumbra-after-focal-photothrombotic-infarction-in-the-rat-cerebral-cortex
#7
Anatoly Uzdensky, Svetlana Demyanenko, Grigory Fedorenko, Tayana Lapteva, Alexej Fedorenko
After ischemic stroke, cell damage propagates from infarct core to surrounding tissues (penumbra). To reveal proteins involved in neurodegeneration and neuroprotection in penumbra, we studied protein expression changes in 2-mm ring around the core of photothrombotic infarct induced in the rat brain cortex by local laser irradiation after administration of Bengal Rose. The ultrastructural study showed edema and degeneration of neurons, glia, and capillaries. Morphological changes gradually decreased across the penumbra...
June 21, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27125645/manganese-exposure-disrupts-snare-protein-complex-mediated-vesicle-fusion-in-primary-cultured-neurons
#8
Can Wang, Bin Xu, Qi-Fan Song, Yu Deng, Wei Liu, Zhao-Fa Xu
Overexposure to manganese (Mn) has been known to disrupt neurotransmitter release in the brain. However, the underlying mechanisms of Mn exposure on neurotransmitter vesicle release are still unclear. The current study investigated whether the protein expression and their interaction of SNARE complex associated proteins were the media between Mn exposure and neurotransmitter vesicle fusion disorders. After the neurons were respectively exposed to Mn (0-200 μM) for 0, 6, 12, 18, 24 h, there were different degrees of cell injury in neurons...
April 29, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/27067299/evaluation-of-automated-fracture-risk-assessment-based-on-the-canadian-association-of-radiologists-and-osteoporosis-canada-assessment-tool
#9
Sonya Allin, Robert Bleakney, Julie Zhang, Sarah Munce, Angela M Cheung, Susan Jaglal
Fracture risk assessments are not always clearly communicated on bone mineral density (BMD) reports; evidence suggests that structured reporting (SR) tools may improve report clarity. The aim of this study is to compare fracture risk assessments automatically assigned by SR software in accordance with Canadian Association of Radiologists and Osteoporosis Canada (CAROC) recommendations to assessments from experts on narrative BMD reports. Charts for 500 adult patients who recently received a BMD exam were sampled from across University of Toronto's Joint Department of Medical Imaging...
July 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/26904357/understanding-referral-patterns-for-bone-mineral-density-testing-among-family-physicians-a-qualitative-descriptive-study
#10
Sarah E P Munce, Sonya Allin, Leslie Carlin, Joanna Sale, Gillian Hawker, Sandra Kim, Debra A Butt, Irene Polidoulis, Karen Tu, Susan B Jaglal
Introduction. Evidence of inappropriate bone mineral density (BMD) testing has been identified in terms of overtesting in low risk women and undertesting among patients at high risk. In light of these phenomena, the objective of this study was to understand the referral patterns for BMD testing among Ontario's family physicians (FPs). Methods. A qualitative descriptive approach was adopted. Twenty-two FPs took part in a semi-structured interview lasting approximately 30 minutes. An inductive thematic analysis was performed on the transcribed data in order to understand the referral patterns for BMD testing...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/26801243/meaning-of-self-management-from-the-perspective-of-individuals-with-traumatic-spinal-cord-injury-their-caregivers-and-acute-care-and-rehabilitation-managers-an-opportunity-for-improved-care-delivery
#11
Sarah E P Munce, Fiona Webster, Michael G Fehlings, Sharon E Straus, Eunice Jang, Susan B Jaglal
BACKGROUND: The trend of decreasing length of stay in rehabilitation facilities has led to individuals with spinal cord injury (SCI) entering the community with unmet needs and fewer self-care skills to prevent secondary complications. The implementation of a self-management program for individuals with SCI for the management of these complex needs, including secondary complications, may be one option to fill these care gaps. A greater understanding of the meaning of self-management may facilitate the development of a tailored self-management program in this population...
2016: BMC Neurology
https://www.readbyqxmd.com/read/26771955/munc18-2-is-required-for-syntaxin-11-localization-on-the-plasma-membrane-in-cytotoxic-t-lymphocytes
#12
Nele M G Dieckmann, Yvonne Hackmann, Maurizio Aricò, Gillian M Griffiths
Cytotoxic T-lymphocytes (CTL) kill their targets by cytolytic granule secretion at the immunological synapse. The Sec/Munc protein, Munc18-2, and its binding partner Syntaxin 11 (STX11) are both required for granule secretion, with mutations in either leading to the primary immunodeficiency, Familial Haemophagocytic Lymphohistiocytosis (FHL4 and 5). Understanding how Munc18-2 and STX11 function in CTL has been hampered by not knowing the endogenous localization of these proteins. Using a novel FHL5 Munc18-2 mutation that results in loss of protein, cytotoxicity and degranulation together with CTL from an FHL4 patient lacking STX11, enabled us to localize endogenous STX11 and Munc18-2 in CTL...
December 2015: Traffic
https://www.readbyqxmd.com/read/26531025/expression-of-neuronal-and-signaling-proteins-in-penumbra-around-a-photothrombotic-infarction-core-in-rat-cerebral-cortex
#13
S V Demyanenko, S N Panchenko, A B Uzdensky
Photodynamic impact on animal cerebral cortex using water-soluble Bengal Rose as a photosensitizer, which does not cross the blood-brain barrier and remains in blood vessels, induces platelet aggregation, vessel occlusion, and brain tissue infarction. This reproduces ischemic stroke. Irreversible cell damage within the infarction core propagates to adjacent tissue and forms a transition zone - the penumbra. Tissue necrosis in the infarction core is too fast (minutes) to be prevented, but much slower penumbral injury (hours) can be limited...
June 2015: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/26508555/a-unique-snare-machinery-for-exocytosis-of-cytotoxic-granules-and-platelets-granules
#14
REVIEW
Bor Luen Tang
Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells target infected or transformed cells with perforin-containing cytotoxic granules through immune synapses, while platelets secrete several types of granules which contents are essential for thrombosis and hemostasis. Recent work has culminated in the notion that an exocytic SNARE complex, based on a very similar set of components, is primarily responsible for exocytosis of the diverse granules in these different cell types. Granule exocytosis is, in particular, uniquely dependent on the atypical Q-SNARE syntaxin 11, its interacting partners of the Sec/Munc (SM) family, and is regulated by Rab27a...
2015: Molecular Membrane Biology
https://www.readbyqxmd.com/read/26395371/the-aspergillus-nidulans-syntaxin-pepa-pep12-is-regulated-by-two-sec1-munc-18-proteins-to-mediate-fusion-events-at-early-endosomes-late-endosomes-and-vacuoles
#15
Manuel S López-Berges, Mario Pinar, Juan F Abenza, Herbert N Arst, Miguel A Peñalva
Syntaxins are target-SNAREs that crucially contribute to determine membrane compartment identity. Three syntaxins, Tlg2p, Pep12p and Vam3p, organize the yeast endovacuolar system. Remarkably, filamentous fungi lack the equivalent of the yeast vacuolar syntaxin Vam3p, making unclear how these organisms regulate vacuole fusion. We show that the nearly essential Aspergillus nidulans syntaxin PepA(Pep12) , present in all endocytic compartments between early endosomes and vacuoles, shares features of Vam3p and Pep12p, and is capable of forming compositional equivalents of all known yeast endovacuolar SNARE bundles including that formed by yeast Vam3p for vacuolar fusion...
January 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/26297964/the-effects-of-the-cellular-and-infectious-prion-protein-on-the-neuronal-adaptor-protein-x11%C3%AE
#16
Jack O'Sullivan, Emma Comerford, Walid Rachidi, Michael Scott, Nigel M Hooper, Hilary E M McMahon
BACKGROUND: The neuronal adaptor protein X11α is a multidomain protein with a phosphotyrosine binding (PTB) domain, two PDZ (PSD_95, Drosophila disks-large, ZO-1) domains, a Munc Interacting (MI) domain and a CASK interacting region. Amongst its functions is a role in the regulation of the abnormal processing of the amyloid precursor protein (APP). It also regulates the activity of Cu/Zn Superoxide dismutase (SOD1) through binding with its chaperone the copper chaperone for SOD1. How X11α production is controlled has remained unclear...
November 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26055818/impact-of-psychological-characteristics-in-self-management-in-individuals-with-traumatic-spinal-cord-injury
#17
S E P Munce, S E Straus, M G Fehlings, J Voth, N Nugaeva, E Jang, F Webster, S B Jaglal
STUDY DESIGN: Cross-sectional survey. OBJECTIVE: To examine the association between psychological characteristics in self-management and probable depression status in individuals with a traumatic spinal cord injury (SCI). SETTING: Community-dwelling individuals with traumatic SCI living across Canada. METHODS: Individuals with SCI were recruited by email via the Rick Hansen Institute as well as an outpatient hospital spinal clinic...
January 2016: Spinal Cord
https://www.readbyqxmd.com/read/25954325/capture-of-osteoporosis-and-fracture-information-in-an-electronic-medical-record-database-from-primary-care
#18
Sonya Allin, Sarah Munce, Susan Jaglal, Debra Butt, Jacqueline Young, Karen Tu
In a large database of EMR records, we explore: 1) completeness in capture of bone mineral density (BMD) T-scores required for diagnosis of osteoporosis; 2) concordance of BMD exam information with other osteoporosis information; and 3) evidence of osteoporosis screening among fracture patients. To explore completeness of exam capture, BMD exams in the EMR were related to a provincial billing database. To explore concordance of information and screening rates, 7500 EMR records were reviewed for osteoporosis and fracture details...
2014: AMIA ... Annual Symposium Proceedings
https://www.readbyqxmd.com/read/25947912/diacylglycerol-signaling-pathway-in-pancreatic-%C3%AE-cells-an-essential-role-of-diacylglycerol-kinase-in-the-regulation-of-insulin-secretion
#19
REVIEW
Yukiko K Kaneko, Tomohisa Ishikawa
Diacylglycerol (DAG) is a lipid signal messenger and plays a physiological role in β-cells. Since defective glucose homeostasis increases de novo DAG synthesis, DAG may also contribute to β-cell dysfunction in type 2 diabetes. Although the primary function of DAG is to activate protein kinase C (PKC), the role of PKC in insulin secretion is controversial: PKC has been reported to act as both a positive and negative regulator of insulin secretion. In addition to the PKC pathway, DAG has also been shown to mediate other pathways such as the Munc-13-dependent pathway in β-cells...
2015: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/25795302/chaperoning-of-closed-syntaxin-3-through-lys46-and-glu59-in-domain-1-of-munc18-proteins-is-indispensable-for-mast-cell-exocytosis
#20
Na-Ryum Bin, Chang Hun Jung, Byungjin Kim, Prashanth Chandrasegram, Ekaterina Turlova, Dan Zhu, Herbert Y Gaisano, Hong-Shuo Sun, Shuzo Sugita
Understanding how Munc18 proteins govern exocytosis is crucial because mutations of this protein cause severe secretion deficits in neuronal and immune cells. Munc18-2 has indispensable roles in the degranulation of mast cell, partly by binding and chaperoning a subset of syntaxin isoforms. However, the key syntaxin that, crucially, participates in the degranulation – whose levels and intracellular localization are regulated by Munc18-2 – remains unknown. Here, we demonstrate that double knockdown of Munc18-1 and Munc-2 in mast cells results in greatly reduced degranulation accompanied with strikingly compromised expression levels and localization of syntaxin-3...
May 15, 2015: Journal of Cell Science
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