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https://www.readbyqxmd.com/read/29674253/involvement-of-snare-complex-in-the-hippocampus-and-prefrontal-cortex-of-offspring-with-depression-induced-by-prenatal-stress
#1
Yan Jun Cao, Qiong Wang, Xing Xing Zheng, Ying Cheng, Yan Zhang
BACKGROUND: Prenatal stress (PS) exposure can cause depression-like behavior in offspring, and maladaptive responses including physiological and neurobiological changes. Glutamate neurotransmission is implicated in effects of PS and in antidepressant mechanisms; however, the mechanisms underlying its involvement remain unclear. In the synapse, the formation of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for vesicular docking and neurotransmitter release...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29611774/examining-physiotherapist-use-of-structured-aerobic-exercise-testing-to-decrease-barriers-to-aerobic-exercise
#2
Evan Foster B Sc, Julia E Fraser, Elizabeth L Inness PhD, Sarah Munce, Louis Biasin, Vivien Poon, Mark Bayley
OBJECTIVE: To determine the frequency of physiotherapist-administered aerobic exercise testing/training, the proportion of physiotherapists who administer this testing/training, and the barriers that currently exist across different practice environments. A secondary objective is to identify the learning needs of physiotherapists for the development of an education curriculum in aerobic exercise testing and training with electrocardiograph (ECG) administration and interpretation. DESIGN: National, cross-sectional survey...
April 3, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29609662/considerations-for-expanding-community-exercise-programs-incorporating-a-healthcare-recreation-partnership-for-people-with-balance-and-mobility-limitations-a-mixed-methods-evaluation
#3
Nancy M Salbach, Jo-Anne Howe, Diem Baldry, Saira Merali, Sarah E P Munce
OBJECTIVE: To increase access to safe and appropriate exercise for people with balance and mobility limitations, community organizations have partnered with healthcare providers to deliver an evidence-based, task-oriented group exercise program in community centers in Canada. We aimed to understand challenges and solutions to implementing this program model to inform plans for expansion. RESULTS: At a 1-day meeting, 53 stakeholders (healthcare/recreation personnel, program participants/caregivers, researchers) identified challenges to program implementation that were captured by seven themes: Resources to deliver the exercise class (e...
April 2, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29599780/bi-allelic-mutations-in-stxbp2-reveal-a-complementary-role-for-stxbp1-in-cytotoxic-lymphocyte-killing
#4
Jamie A Lopez, Tahereh Noori, Adrian Minson, Lu Li Jovanoska, Kevin Thia, Michael S Hildebrand, Hedieh Akhlaghi, Phillip K Darcy, Michael H Kershaw, Natasha J Brown, Andrew Grigg, Joseph A Trapani, Ilia Voskoboinik
The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis death pathway is critical to immune homeostasis. Congenital loss of CL function due to bi-allelic mutations in PRF1, UNC13D, STX11 , or STXBP2 leads to a potentially fatal immune dysregulation, familial haemophagocytic lymphohistiocytosis (FHL). This occurs due to the failure of CLs to release functional pore-forming protein perforin and, therefore, inability to kill the target cell...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29579710/bu-shen-zhu-yun-decoction-promotes-synthesis-and-secretion-of-fsh%C3%AE-and-lh%C3%AE-in-anterior-pituitary-cells-in-vitro
#5
Xiaofei Jiang, Huifang Zhou, Mingqing Shi, Boru Zhou, Bei Liu, Yizhen Yuan, Jinjun Shan, Jianya Xu, Tong Xie
Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivity. The aim of present study was to determine the effect of BSZY-D on the synthesis and secretion of gonadotropic hormones in the anterior pituitary cells of rats...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29563075/participatory-design-of-an-online-self-management-tool-for-users-with-spinal-cord-injury-qualitative-study
#6
Sonya Allin, John Shepherd, Jennifer Tomasone, Sarah Munce, Gary Linassi, Saima Noreen Hossain, Susan Jaglal
BACKGROUND: Rehospitalization rates resulting from secondary conditions in persons with spinal cord injuries (SCI) are high. Self-management programs for many chronic conditions have been associated with decreases in hospital readmissions. However, in the SCI community, evidence suggests that satisfaction with traditional self-management programs is low. Users with SCI have indicated preference for programs that are online (rather than in-person), that target SCI-specific concerns, and are led by peers with SCI...
March 21, 2018: JMIR Rehabilitation and Assistive Technologies
https://www.readbyqxmd.com/read/29402503/environmental-training-is-beneficial-to-clinical-symptoms-and-cortical-presynaptic-defects-in-mice-suffering-from-experimental-autoimmune-encephalomyelitis
#7
T Bonfiglio, G Olivero, M Vergassola, L Di Cesare Mannelli, A Pacini, F Iannuzzi, M Summa, R Bertorelli, M Feligioni, C Ghelardini, A Pittaluga
The effect of "prophylactic" environmental stimulation on clinical symptoms and presynaptic defects in mice suffering from the experimental autoimmune encephalomyelitis (EAE) at the acute stage of disease (21 ± 1 days post immunization, d.p.i.) was investigated. In EAE mice raised in an enriched environment (EE), the clinical score was reduced when compared to EAE mice raised in standard environment (SE).Concomitantly, gain of weight and increased spontaneous motor activity and curiosity were observed, suggesting increased well-being in mice...
February 2, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29391075/health-and-community-based-services-for-individuals-with-neurological-conditions
#8
Sarah E P Munce, Kristen B Pitzul, Sara J T Guilcher, Tarik Bereket, Mae Kwan, James Conklin, Joan Versnel, Tanya Packer, Molly Verrier, Connie Marras, Richard Riopelle, Susan B Jaglal
BACKGROUND: The current study involves a national survey of healthcare providers who offer services for individuals with a variety of neurological conditions. It aims to describe the provision of health and community-based services as well as the admission criteria, waitlist practices, and referral sources of these services. METHODS: An online survey was directed at administrators/managers from publicly funded hospital programs, long-term care homes, and community-based healthcare provider agencies that were believed to be providing information and/or services to patients with a variety of neurological conditions...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29359959/the-ketogenic-diet-as-a-treatment-for-traumatic-brain-injury-a-scoping-review
#9
Alexandre McDougall, Mark Bayley, Sarah Ep Munce
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. The ketogenic diet (KD) has been identified as a potential therapy to enhance recovery after TBI. The purpose of this study is to complete a scoping review and synthesize the evidence regarding the KD and its therapeutic effects in TBI. The methodological framework of Arksey and O'Malley was employed. Databases searched include Medline, EMBASE, CCRCT, CINAHL and WebOfScience. Two reviewers independently screened titles, abstracts and full texts in a two-step screening protocol to determine inclusion...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29341789/psychometric-properties-of-the-epworth-sleepiness-scale-a-factor-analysis-and-item-response-theory-approach
#10
June J Pilcher, Fred S Switzer, Alec Munc, Janet Donnelly, Julia C Jellen, Claus Lamm
The purpose of this study is to examine the psychometric properties of the Epworth Sleepiness Scale (ESS) in two languages, German and English. Students from a university in Austria (N = 292; 55 males; mean age = 18.71 ± 1.71 years; 237 females; mean age = 18.24 ± 0.88 years) and a university in the US (N = 329; 128 males; mean age = 18.71 ± 0.88 years; 201 females; mean age = 21.59 ± 2.27 years) completed the ESS. An exploratory-factor analysis was completed to examine dimensionality of the ESS...
January 17, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29327631/the-association-between-adverse-childhood-experiences-and-adult-traumatic-brain-injury-concussion-a-scoping-review
#11
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Christine Lay, Sarah E P Munce
BACKGROUND: Adverse childhood experiences are significant risk factors for physical and mental illnesses in adulthood. Traumatic brain injury/concussion is a challenging condition where pre-injury factors may affect recovery. The association between childhood adversity and traumatic brain injury/concussion has not been previously reviewed. The research question addressed is: What is known from the existing literature about the association between adverse childhood experiences and traumatic brain injury/concussion in adults? METHODS: All original studies of any type published in English since 2007 on adverse childhood experiences and traumatic brain injury/concussion outcomes were included...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29043392/complex-interventions-can-increase-osteoporosis-investigations-and-treatment-a-systematic-review-and-meta-analysis
#12
REVIEW
M Kastner, L Perrier, S E P Munce, C C Adhihetty, A Lau, J Hamid, V Treister, J Chan, Y Lai, S E Straus
Osteoporosis is affecting over 200 million people worldwide. Despite available guidelines, care for these patients remains sub-optimal. We developed an osteoporosis tool to address the multiple dimensions of chronic disease management. Findings from its evaluation showed a significant increase from baseline in osteoporosis investigations and treatment, so we are revising this tool to include multiple chronic conditions including an update of evidence about osteoporosis. Our objectives were to conduct a systematic review of osteoporosis interventions in adults at risk for osteoporosis...
January 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29025849/the-association-between-adverse-childhood-experiences-and-traumatic-brain-injury-concussion-in-adulthood-a-scoping-review-protocol
#13
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Sarah Ep Munce
INTRODUCTION: Exposure to adverse childhood experiences (ACEs) is a significant risk factor for physical and mental illnesses later in life. Concussion or traumatic brain injury is a challenging condition where preinjury factors may interact to affect recovery. The association between ACEs and traumatic brain injury/concussion is not well mapped in any previous reviews of the literature. Using a scoping review methodology, the research question that will be addressed is: what is known from the existing literature about the association between ACEs and traumatic brain injury/concussion in adults? METHODS AND ANALYSIS: The methodological frameworks outlined by Arksey and O'Malley and Levac et al will be used...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28947464/online-peer-support-interventions-for-chronic-conditions-a-scoping-review-protocol
#14
Sarah Elizabeth Patricia Munce, John Shepherd, Laure Perrier, Sonya Allin, Shane N Sweet, Jennifer R Tomasone, Michelle L A Nelson, Sara J T Guilcher, Saima Hossain, Susan Jaglal
INTRODUCTION: Peer support is receiving increasing attention as both an effective and cost-effective intervention method to support the self-management of chronic health conditions. Given that an increasing proportion of Canadians have internet access and the increasing implementation of web-based interventions, online peer support interventions are a promising option to address the burden of chronic diseases. Thus, the specific research question of this scoping review is the following: What is known from the existing literature about the key characteristics of online peer support interventions for adults with chronic conditions? METHODS AND ANALYSIS: We will use the methodological frameworks used by Arksey and O'Malley as well as Levac and colleagues for the current scoping review...
September 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28947162/addressing-the-evidence-gap-in-stroke-rehabilitation-for-complex-patients-a-preliminary-research-agenda
#15
Michelle L Nelson, Kaileah A McKellar, Sarah Munce, Linda Kelloway, Parminder Kaur Hans, Martin Fortin, Renee Lyons, Mark Bayley
Evidence suggests that a stroke occurs in isolation (no comorbid conditions) in less than 6% of patients. Multimorbidity, compounded by psychosocial issues, makes treatment and recovery for stroke increasingly complex. Recent research and health policy documents called for a better understanding of the needs of this patient population, and for the development and testing of models of care that meet their needs. A research agenda specific to complexity is required. The primary objective of the think tank was to identify and prioritize research questions that meet the information needs of stakeholders, and to develop a research agenda specific to stroke rehabilitation and patient complexity...
September 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28887184/chronic-fluoxetine-administration-enhances-synaptic-plasticity-and-increases-functional-dynamics-in-hippocampal-ca3-ca1-synapses
#16
Dina Popova, Eero Castrén, Tomi Taira
Recent studies demonstrate that chronic administration of the widely used antidepressant fluoxetine (FLX) promotes neurogenesis, synaptogenesis and synaptic plasticity in the adult hippocampus, cortex and amygdala. However, the mechanisms underlying these effects and how are they related to the clinical antidepressant efficacy are still poorly understood. We show here that chronic FLX administration decreases hippocampus-associated neophobia in naïve mice. In parallel, electrophysiological recordings in hippocampal CA3-CA1 circuitry revealed that the FLX treatment resulted in increased short- and long-term plasticity likely attributed to changes in presynaptic function...
November 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28882175/strategies-to-improve-the-quality-of-life-of-persons-post-stroke-protocol-of-a-systematic-review
#17
Sarah E P Munce, Laure Perrier, Saeha Shin, Chamila Adhihetty, Kristen Pitzul, Michelle L A Nelson, Mark T Bayley
BACKGROUND: While many outcomes post-stroke (e.g., depression) have been previously investigated, there is no complete data on the impact of a variety of quality improvement strategies on the quality of life and physical and psychological well-being of individuals post-stroke. The current paper outlines a systematic review protocol on the impact of quality improvement strategies on quality of life as well as physical and psychological well-being of individuals with stroke. METHODS: MEDLINE, CINAHL, EMBASE, and PsycINFO databases will be searched...
September 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28758540/using-the-theoretical-domains-framework-to-guide-the-development-of-a-self-management-program-for-individuals-with-spinal-cord-injury-results-from-a-national-stakeholder-advisory-group
#18
Sarah E P Munce, Sonya Allin, Dalton L Wolfe, Karen Anzai, Gary Linassi, Vanessa K Noonan, Susan B Jaglal
OBJECTIVE: To determine the implementation considerations for a targeted self-management program for individuals with spinal cord injury (SCI) from the perspective of a national stakeholder advisory group using the Theoretical Domains Framework (TDF) as a guide. DESIGN: Qualitative descriptive approach. SETTING: Two focus groups held at the 6th National Spinal Cord Injury Conference (October 2-4th , 2014) in Toronto, Ontario, Canada. PARTICIPANTS: A total of 25 stakeholders from across Canada participated in focus groups or "brainstorming sessions"...
November 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28651530/perspectives-of-health-care-professionals-on-the-facilitators-and-barriers-to-the-implementation-of-a-stroke-rehabilitation-guidelines-cluster-randomized-controlled-trial
#19
Sarah E P Munce, Ian D Graham, Nancy M Salbach, Susan B Jaglal, Carol L Richards, Janice J Eng, Johanne Desrosiers, Marilyn MacKay-Lyons, Sharon Wood-Dauphinee, Nicol Korner-Bitensky, Nancy E Mayo, Robert W Teasell, Merrick Zwarenstein, Jennifer Mokry, Sandra Black, Mark T Bayley
BACKGROUND: The Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial (SCORE-IT) was a cluster randomized controlled trial that evaluated two knowledge translation (KT) interventions for the promotion of the uptake of best practice recommendations for interventions targeting upper and lower extremity function, postural control, and mobility. Twenty rehabilitation centers across Canada were randomly assigned to either the facilitated or passive KT intervention. The objective of the current study was to understand the factors influencing the implementation of the recommended treatments and KT interventions from the perspective of nurses, occupational therapists and physical therapists, and clinical managers following completion of the trial...
June 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28426513/evaluation-of-the-functional-movement-screen-and-a-novel-basketball-mobility-test-as-an-injury-prediction-tool-for-collegiate-basketball-players
#20
Colin W Bond, Jason C Dorman, Tryg O Odney, Scott J Roggenbuck, Steven W Young, Thayne A Munce
Identifying injury risk and implementing preventive measures can assist in reducing injury occurrence and may ultimately improve athletic performance. Improper movement patterns often contribute to musculoskeletal (MSK) injuries. The validity of the Functional Movement Screen (FMS™) as an injury prediction tool for athletes remains unclear. We designed the Basketball-Specific Mobility Test (BMT) to represent the neuromuscular demands of basketball and identify deficiencies that may be indicative of greater MSK injury risk while playing this sport...
April 15, 2017: Journal of Strength and Conditioning Research
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