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T Bonfiglio, G Olivero, M Vergassola, L Di Cesare Mannelli, A Pacini, F Iannuzzi, M Summa, R Bertorelli, M Feligioni, C Ghelardini, A Pittaluga
The effect of "prophylactic" environmental stimulation on clinical symptoms and presynaptic defects in mice suffering from the experimental autoimmune encephalomyelitis (EAE) at the acute stage of disease (21 ± 1 days post immunization, d.p.i.) was investigated. In EAE mice raised in an enriched environment (EE), the clinical score was reduced when compared to EAE mice raised in standard environment (SE).Concomitantly, gain of weight and increased spontaneous motor activity and curiosity were observed, suggesting increased well-being in mice...
February 2, 2018: Neuropharmacology
Sarah E P Munce, Kristen B Pitzul, Sara J T Guilcher, Tarik Bereket, Mae Kwan, James Conklin, Joan Versnel, Tanya Packer, Molly Verrier, Connie Marras, Richard Riopelle, Susan B Jaglal
BACKGROUND: The current study involves a national survey of healthcare providers who offer services for individuals with a variety of neurological conditions. It aims to describe the provision of health and community-based services as well as the admission criteria, waitlist practices, and referral sources of these services. METHODS: An online survey was directed at administrators/managers from publicly funded hospital programs, long-term care homes, and community-based healthcare provider agencies that were believed to be providing information and/or services to patients with a variety of neurological conditions...
November 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Alexandre McDougall, Mark Bayley, Sarah Ep Munce
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality worldwide. The ketogenic diet (KD) has been identified as a potential therapy to enhance recovery after TBI. The purpose of this study is to complete a scoping review and synthesize the evidence regarding the KD and its therapeutic effects in TBI. The methodological framework of Arksey and O'Malley was employed. Databases searched include Medline, EMBASE, CCRCT, CINAHL and WebOfScience. Two reviewers independently screened titles, abstracts and full texts in a two-step screening protocol to determine inclusion...
January 23, 2018: Brain Injury: [BI]
June J Pilcher, Fred S Switzer, Alec Munc, Janet Donnelly, Julia C Jellen, Claus Lamm
The purpose of this study is to examine the psychometric properties of the Epworth Sleepiness Scale (ESS) in two languages, German and English. Students from a university in Austria (N = 292; 55 males; mean age = 18.71 ± 1.71 years; 237 females; mean age = 18.24 ± 0.88 years) and a university in the US (N = 329; 128 males; mean age = 18.71 ± 0.88 years; 201 females; mean age = 21.59 ± 2.27 years) completed the ESS. An exploratory-factor analysis was completed to examine dimensionality of the ESS...
January 17, 2018: Chronobiology International
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Christine Lay, Sarah E P Munce
BACKGROUND: Adverse childhood experiences are significant risk factors for physical and mental illnesses in adulthood. Traumatic brain injury/concussion is a challenging condition where pre-injury factors may affect recovery. The association between childhood adversity and traumatic brain injury/concussion has not been previously reviewed. The research question addressed is: What is known from the existing literature about the association between adverse childhood experiences and traumatic brain injury/concussion in adults? METHODS: All original studies of any type published in English since 2007 on adverse childhood experiences and traumatic brain injury/concussion outcomes were included...
January 12, 2018: Disability and Rehabilitation
M Kastner, L Perrier, S E P Munce, C C Adhihetty, A Lau, J Hamid, V Treister, J Chan, Y Lai, S E Straus
Osteoporosis is affecting over 200 million people worldwide. Despite available guidelines, care for these patients remains sub-optimal. We developed an osteoporosis tool to address the multiple dimensions of chronic disease management. Findings from its evaluation showed a significant increase from baseline in osteoporosis investigations and treatment, so we are revising this tool to include multiple chronic conditions including an update of evidence about osteoporosis. Our objectives were to conduct a systematic review of osteoporosis interventions in adults at risk for osteoporosis...
October 18, 2017: Osteoporosis International
Zechen Ma, Mark T Bayley, Laure Perrier, Priya Dhir, Lana Dépatie, Paul Comper, Lesley Ruttan, Sarah Ep Munce
INTRODUCTION: Exposure to adverse childhood experiences (ACEs) is a significant risk factor for physical and mental illnesses later in life. Concussion or traumatic brain injury is a challenging condition where preinjury factors may interact to affect recovery. The association between ACEs and traumatic brain injury/concussion is not well mapped in any previous reviews of the literature. Using a scoping review methodology, the research question that will be addressed is: what is known from the existing literature about the association between ACEs and traumatic brain injury/concussion in adults? METHODS AND ANALYSIS: The methodological frameworks outlined by Arksey and O'Malley and Levac et al will be used...
October 11, 2017: BMJ Open
Sarah Elizabeth Patricia Munce, John Shepherd, Laure Perrier, Sonya Allin, Shane N Sweet, Jennifer R Tomasone, Michelle L A Nelson, Sara J T Guilcher, Saima Hossain, Susan Jaglal
INTRODUCTION: Peer support is receiving increasing attention as both an effective and cost-effective intervention method to support the self-management of chronic health conditions. Given that an increasing proportion of Canadians have internet access and the increasing implementation of web-based interventions, online peer support interventions are a promising option to address the burden of chronic diseases. Thus, the specific research question of this scoping review is the following: What is known from the existing literature about the key characteristics of online peer support interventions for adults with chronic conditions? METHODS AND ANALYSIS: We will use the methodological frameworks used by Arksey and O'Malley as well as Levac and colleagues for the current scoping review...
September 24, 2017: BMJ Open
Michelle L Nelson, Kaileah A McKellar, Sarah Munce, Linda Kelloway, Parminder Kaur Hans, Martin Fortin, Renee Lyons, Mark Bayley
Evidence suggests that a stroke occurs in isolation (no comorbid conditions) in less than 6% of patients. Multimorbidity, compounded by psychosocial issues, makes treatment and recovery for stroke increasingly complex. Recent research and health policy documents called for a better understanding of the needs of this patient population, and for the development and testing of models of care that meet their needs. A research agenda specific to complexity is required. The primary objective of the think tank was to identify and prioritize research questions that meet the information needs of stakeholders, and to develop a research agenda specific to stroke rehabilitation and patient complexity...
September 22, 2017: Archives of Physical Medicine and Rehabilitation
Dina Popova, Eero Castrén, Tomi Taira
Recent studies demonstrate that chronic administration of the widely used antidepressant fluoxetine (FLX) promotes neurogenesis, synaptogenesis and synaptic plasticity in the adult hippocampus, cortex and amygdala. However, the mechanisms underlying these effects and how are they related to the clinical antidepressant efficacy are still poorly understood. We show here that chronic FLX administration decreases hippocampus-associated neophobia in naïve mice. In parallel, electrophysiological recordings in hippocampal CA3-CA1 circuitry revealed that the FLX treatment resulted in increased short- and long-term plasticity likely attributed to changes in presynaptic function...
November 2017: Neuropharmacology
Sarah E P Munce, Laure Perrier, Saeha Shin, Chamila Adhihetty, Kristen Pitzul, Michelle L A Nelson, Mark T Bayley
BACKGROUND: While many outcomes post-stroke (e.g., depression) have been previously investigated, there is no complete data on the impact of a variety of quality improvement strategies on the quality of life and physical and psychological well-being of individuals post-stroke. The current paper outlines a systematic review protocol on the impact of quality improvement strategies on quality of life as well as physical and psychological well-being of individuals with stroke. METHODS: MEDLINE, CINAHL, EMBASE, and PsycINFO databases will be searched...
September 7, 2017: Systematic Reviews
Sarah E P Munce, Sonya Allin, Dalton L Wolfe, Karen Anzai, Gary Linassi, Vanessa K Noonan, Susan B Jaglal
OBJECTIVE: To determine the implementation considerations for a targeted self-management program for individuals with spinal cord injury (SCI) from the perspective of a national stakeholder advisory group using the Theoretical Domains Framework (TDF) as a guide. DESIGN: Qualitative descriptive approach. SETTING: Two focus groups held at the 6(th) National Spinal Cord Injury Conference (October 2-4(th), 2014) in Toronto, Ontario, Canada. PARTICIPANTS: A total of 25 stakeholders from across Canada participated in focus groups or "brainstorming sessions"...
July 30, 2017: Journal of Spinal Cord Medicine
Sarah E P Munce, Ian D Graham, Nancy M Salbach, Susan B Jaglal, Carol L Richards, Janice J Eng, Johanne Desrosiers, Marilyn MacKay-Lyons, Sharon Wood-Dauphinee, Nicol Korner-Bitensky, Nancy E Mayo, Robert W Teasell, Merrick Zwarenstein, Jennifer Mokry, Sandra Black, Mark T Bayley
BACKGROUND: The Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial (SCORE-IT) was a cluster randomized controlled trial that evaluated two knowledge translation (KT) interventions for the promotion of the uptake of best practice recommendations for interventions targeting upper and lower extremity function, postural control, and mobility. Twenty rehabilitation centers across Canada were randomly assigned to either the facilitated or passive KT intervention. The objective of the current study was to understand the factors influencing the implementation of the recommended treatments and KT interventions from the perspective of nurses, occupational therapists and physical therapists, and clinical managers following completion of the trial...
June 26, 2017: BMC Health Services Research
Colin W Bond, Jason C Dorman, Tryg O Odney, Scott J Roggenbuck, Steven W Young, Thayne A Munce
Identifying injury risk and implementing preventive measures can assist in reducing injury occurrence and may ultimately improve athletic performance. Improper movement patterns often contribute to musculoskeletal (MSK) injuries. The validity of the Functional Movement Screen (FMS™) as an injury prediction tool for athletes remains unclear. We designed the Basketball-Specific Mobility Test (BMT) to represent the neuromuscular demands of basketball and identify deficiencies that may be indicative of greater MSK injury risk while playing this sport...
April 15, 2017: Journal of Strength and Conditioning Research
Suzanne Guénette, Paul Strecker, Stefan Kins
Understanding the molecular mechanisms underlying amyloid precursor protein family (APP/APP-like proteins, APLP) function in the nervous system can be achieved by studying the APP/APLP interactome. In this review article, we focused on intracellular APP interacting proteins that bind the YENPTY internalization motif located in the last 15 amino acids of the C-terminal region. These proteins, which include X11/Munc-18-interacting proteins (Mints) and FE65/FE65Ls, represent APP cytosolic binding partners exhibiting different neuronal functions...
2017: Frontiers in Molecular Neuroscience
Qian-Yin Xiong, Cui Yu, Yao Zhang, Liefeng Ling, Lizhuo Wang, Jia-Lin Gao
In vivo insulin secretion is predominantly affected by blood glucose concentration, blood concentration of amino acids, gastrointestinal hormones and free nerve functional status, in addition to other factors. Insulin is one of the most important hormones in the body, and its secretion is precisely controlled by nutrients, neurotransmitters and hormones. The insulin exocytosis process is similar to the neurotransmitter release mechanism. There are various types of proteins and lipids that participate in the insulin secretory vesicle fusion process, such as soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein, Ras-related proteins and vacuolar-type H(+)-ATPase (V-ATPase)...
February 2017: Biomedical Reports
Kristen B Pitzul, Sarah E P Munce, Laure Perrier, Lauren Beaupre, Suzanne N Morin, Rhona McGlasson, Susan B Jaglal
OBJECTIVE: The purpose of this study is to identify existing or potential quality of care indicators (ie, current indicators as well as process and outcome measures) in the acute or postacute period, or across the continuum of care for older adults with hip fracture. DESIGN: Scoping review. SETTING: All care settings. SEARCH STRATEGY: English peer-reviewed studies published from January 2000 to January 2016 were included...
March 21, 2017: BMJ Open
Waldo A Spessott, Maria L Sanmillan, Margaret E McCormick, Vineet V Kulkarni, Claudio G Giraudo
The atypical lipid-anchored Syntaxin 11 (STX11) and its binding partner, the Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Patients carrying mutations in these genes develop familial hemophagocytic lymphohistiocytosis, a primary immunodeficiency characterized by impaired lytic granule exocytosis. However, whether a SNARE such as STX11, which lacks a transmembrane domain, can support membrane fusion in vivo is uncertain, as is the precise role of Munc18-2 during lytic granule exocytosis...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
Michelle L A Nelson, Kaileah A McKellar, Juliana Yi, Linda Kelloway, Sarah Munce, Cheryl Cott, Ruth Hall, Martin Fortin, Robert Teasell, Renee Lyons
BACKGROUND: Most strokes occur in the context of other medical diagnoses. Currently, stroke rehabilitation evidence reviews have not synthesized or presented evidence with a focus on comorbidities and correspondingly may not align with current patient population. The purpose of this review was to determine the extent and nature of randomized controlled trial stroke rehabilitation evidence that included patients with multimorbidity. METHODS: A systematic scoping review was conducted...
February 20, 2017: Topics in Stroke Rehabilitation
Sara Guilcher, Sarah Munce, James Conklin, Tanya Packer, Molly Verrier, Connie Marras, Tarik Bereket, Joan Versnel, Richard Riopelle, Susan Jaglal
This paper describes the current situation in Canada concerning the availability and use of prescription drugs for neurological conditions. We conducted semi-structured qualitative interviews with health care providers, administrators, community organization representatives, opinion leaders and policy makers. The analysis revealed three primary themes related to the availability of and access to prescription drugs to treat neurological conditions. First, we learned that across Canada there is significant vulnerability and a need for advocacy on behalf of people living with these conditions...
April 2017: Health Policy
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