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https://www.readbyqxmd.com/read/27669680/effects-of-baseline-abdominal-pain-and-bloating-on-response-to-lubiprostone-in-patients-with-irritable-bowel-syndrome-with-constipation
#1
L Chang, W D Chey, D Drossman, T Losch-Beridon, M Wang, P Lichtlen, S Mareya
BACKGROUND: Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both abdominal pain and stool frequency. AIM: In a post hoc analysis, similar criteria were applied to data from two pivotal, phase 3, double-blind, randomised trials of lubiprostone in patients with IBS-C...
November 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27147121/rome-iv-functional-gi-disorders-disorders-of-gut-brain-interaction
#2
Douglas A Drossman, William L Hasler
No abstract text is available yet for this article.
May 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144628/centrally-mediated-disorders-of-gastrointestinal-pain
#3
Laurie Keefer, Douglas A Drossman, Elspeth Guthrie, Magnus Simrén, Kirsten Tillisch, Kevin Olden, Peter J Whorwell
Centrally Mediated Abdominal Pain Syndrome (CAPS), formerly known as Functional Abdominal Pain Syndrome, can be distinguished from other functional GI disorders by its strong central component and relative independence from motility disturbances. CAPS is a result of central sensitization with disinhibition of pain signals rather than increased peripheral afferent excitability. A newly described condition, Narcotic Bowel Syndrome (NBS)/Opioid-Induced GI Hyperalgesia, is characterized by the paradoxical development of or increases in abdominal pain associated with continuous or increasing dosages of opioids...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144624/biopsychosocial-aspects-of-functional-gastrointestinal-disorders
#4
Lukas Van Oudenhove, Michael D Crowell, Douglas A Drossman, Albena D Halpert, Laurie Keefer, Jeffrey M Lackner, Tasha B Murphy, Bruce D Naliboff, Rona L Levy
In this paper, we provide a general framework for understanding the functional gastrointestinal disorders (FGID) from a biopsychosocial perspective. More specifically, we provide an overview of the recent research on how the complex interactions of environmental, psychological, and biological factors contribute to the development and maintenance of the FGID. We emphasize that considering and addressing all these factors is a conditio sine qua non for appropriate treatment of these conditions. First, we provide an overview of what is currently known about how each of these factors - the environment, including the influence of those in an individual's family, the individual's own psychological states and traits, and the individual's (neuro)physiological make-up - interact to ultimately result in the generation of FGID symptoms...
February 18, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27144617/functional-gastrointestinal-disorders-history-pathophysiology-clinical-features-and-rome-iv
#5
Douglas A Drossman
Functional gastrointestinal disorders (FGIDs), the most common diagnoses in gastroenterology are recognized by morphological and physiological abnormalities that often occur in combination including motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota and altered central nervous system processing. Research on these gut-brain interaction disorders is based on using specific diagnostic criteria. The Rome Foundation has played a pivotal role in creating diagnostic criteria thus operationalizing the dissemination of new knowledge in the field of FGIDs...
February 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/26350938/validity-and-reliability-of-the-japanese-version-of-the-rome-iii-diagnostic-questionnaire-for-irritable-bowel-syndrome-and-functional-dyspepsia
#6
Motoyori Kanazawa, Shigemi Nakajima, Tadayuki Oshima, William E Whitehead, Ami D Sperber, Olafur S Palsson, Douglas A Drossman, Hiroto Miwa, Shin Fukudo
BACKGROUND/AIMS: Reliable diagnostic instruments for measuring the presence of functional gastrointestinal disorders based on the Rome III criteria have been lacking in Japan. The aims of the present study were to translate and validate the Rome III diagnostic questionnaire which was widely used in Western countries. METHODS: The original version of Rome III diagnostic questionnaire was translated from English into Japanese through 3 independent forward translations, resolution, back translation and reconciliation of the differences...
October 1, 2015: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/25952801/a-review-of-three-educational-projects-using-interactive-theater-to-improve-physician-patient-communication-when-treating-patients-with-irritable-bowel-syndrome
#7
Ben Saypol, Douglas A Drossman, Max J Schmulson, Carolina Olano, Albena Halpert, Ademola Aderoju, Lin Chang
BACKGROUND: Quality communication skills and increased multicultural sensitivity are universal goals, yet teaching them have remained a challenge for educators. OBJECTIVE: To document the process and participant responses to Interactive Theater when used as a method to teach physician/patient communication and cross-cultural competency. DESIGN, SETTING, AND PARTICIPANTS: Three projects are reported. They were collaborations between Theater Delta, the UNC Center for Functional GI and Motility Disorders, the Rome Foundation, the World Gastroenterology Organization, and the American Gastroenterological Association...
May 2015: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/25651186/centrally-targeted-pharmacotherapy-for-chronic-abdominal-pain
#8
REVIEW
H Törnblom, D A Drossman
BACKGROUND: Chronic abdominal pain in the context of the functional gastrointestinal disorders departs from a more traditional approach to treating gastrointestinal symptoms. Chronic abdominal pain involves a dysregulation of brain-gut modulation of afferent signaling, so treatments directed toward the gut are not usually sufficient to achieve a clinical response. Rather the methods of treatment depend on re-establishing central pain regulation. PURPOSE: A conceptual model of predisposing, precipitating, and perpetuating factors is used to explain how a situation of chronic pain develops and it provides the evidence for central neuron degeneration as relevant to this chain of events...
April 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/25496509/foetal-black-bone-mri-utility-in-assessment-of-the-foetal-spine
#9
A J Robinson, S Blaser, A Vladimirov, D Drossman, D Chitayat, G Ryan
OBJECTIVE: Foetal CT has recently been added to the foetal imaging armamentarium, but this carries with it the risks of ionizing radiation, both to the mother and the foetus. Foetal "black bone" MRI is a new technique that allows assessment of the foetal skeleton without the risk of exposure to ionizing radiation and is a potential new sequence in foetal MRI examination. METHODS: Retrospective review of all foetal MRI studies over the past 4- to 5-year period identified 36 cases where susceptibility weighted imaging was used...
February 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25482042/development-and-pilot-testing-of-an-integrated-web-based-self-management-program-for-irritable-bowel-syndrome-ibs
#10
S D Dorn, O S Palsson, M Woldeghebriel, B Fowler, R McCoy, M Weinberger, D A Drossman
BACKGROUND: Although essential, many medical practices are unable to adequately support irritable bowel syndrome (IBS) patient self-management. Web-based programs can help overcome these barriers. METHODS: We developed, assessed, and refined an integrated IBS self-management program (IBS Self-care). We then conducted a 12-week pilot test to assess program utilization, evaluate its association with patients' self-efficacy and quality of life, and collect qualitative feedback to improve the program...
January 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/25356996/definitions-and-outcome-measures-of-clinical-trials-regarding-opioid-induced-constipation-a-systematic-review
#11
REVIEW
Jan Gaertner, Waldemar Siemens, Michael Camilleri, Andrew Davies, Douglas A Drossman, Lynn R Webster, Gerhild Becker
Opioid-induced constipation (OIC) is a frequent symptom in patients treated with opioids and impacts the patients' quality of life. However, there is no generally accepted definition for OIC. The aims of this study were to identify definitions for OIC in clinical trials and Cochrane Reviews and to compile assessment tools and outcome measures that were used in clinical trials. In a systematic review, 5 databases (MEDLINE, PubMed, The Cochrane Library, Web of Science, and EMBASE) were searched to identify clinical trials assessing OIC in adult patients or healthy volunteers...
January 2015: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/25349684/prevalence-of-narcotic-bowel-syndrome-in-opioid-abusers-in-iran
#12
Bizhan Ahmadi, Peyman Arab, Mohammad Javad Zahedi, Sara Shafieipour, Douglas A Drossman, Ghodseyeh Banivaheb
BACKGROUND In spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (NBS) is undetermined. We aimed to estimate the prevalence of NBS and other opioid bowel dysfunction (OBD) in opioid abusers in Kerman, southeast Iran. According to the best of our knowledge, this is the first study to assess the prevalence of NBS in opioid abusers. METHODS By referring to addiction treatment centers in Kerman city and in a cross-sectional study, 577 subjects with opium or opioid subtracts abuse were included in our study...
October 2014: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/25207609/the-narcotic-bowel-syndrome-a-recent-update
#13
REVIEW
Douglas Drossman, Eva Szigethy
OBJECTIVES: The paradoxical development of chronic abdominal pain is an underrecognized side effect of opioid use. Narcotic bowel syndrome (NBS), occurring in a small proportion of chronic opioid users, consists of chronic or intermittent abdominal pain, which often increases in severity despite continued or escalating dosages of opioids prescribed to relieve pain. METHODS: A PubMed search was conducted using terms such as "narcotic bowel syndrome" and "opioid hyperalgesia" through January 2014...
September 10, 2014: American Journal of Gastroenterology Supplements (Print)
https://www.readbyqxmd.com/read/25183577/narcotic-bowel-syndrome-and-opioid-induced-constipation
#14
REVIEW
Eva Szigethy, Marc Schwartz, Douglas Drossman
Prescription opioid use for chronic non-cancer pain has reached epidemic levels in the USA. With this increased use is the recognition of serious opioid-related gastrointestinal complications such as narcotic bowel syndrome (NBS) and opioid-induced constipation (OIC). NBS consists of a paradoxical worsening of abdominal pain with escalating doses of opioids and is likely mediated by the central nervous system. Therapy requires an intensive multidisciplinary approach to detoxification. OIC is the most common gastrointestinal side effect of opioids...
October 2014: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/25164154/emerging-treatments-in-neurogastroenterology-a-multidisciplinary-working-group-consensus-statement-on-opioid-induced-constipation
#15
REVIEW
M Camilleri, D A Drossman, G Becker, L R Webster, A N Davies, G M Mawe
BACKGROUND: Opioids are effective for acute and chronic pain conditions, but their use is associated with often difficult-to-manage constipation and other gastrointestinal (GI) effects due to effects on peripheral μ-opioid receptors in the gut. The mechanism of opioid-induced constipation (OIC) differs from that of functional constipation (FC), and OIC may not respond as well to most first-line treatments for FC. The impact of OIC on quality of life (QoL) induces some patients to decrease or stop their opioid therapy to relieve or avoid constipation...
October 2014: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/24951847/redux-do-little-bellyachers-grow-up-to-become-big-bellyachers
#16
EDITORIAL
Douglas A Drossman
No abstract text is available yet for this article.
December 2014: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/24867013/effect-of-endoscopic-sphincterotomy-for-suspected-sphincter-of-oddi-dysfunction-on-pain-related-disability-following-cholecystectomy-the-episod-randomized-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Peter B Cotton, Valerie Durkalski, Joseph Romagnuolo, Qi Pauls, Evan Fogel, Paul Tarnasky, Giuseppe Aliperti, Martin Freeman, Richard Kozarek, Priya Jamidar, Mel Wilcox, Jose Serrano, Olga Brawman-Mintzer, Grace Elta, Patrick Mauldin, Andre Thornhill, Robert Hawes, April Wood-Williams, Kyle Orrell, Douglas Drossman, Patricia Robuck
IMPORTANCE: Abdominal pain after cholecystectomy is common and may be attributed to sphincter of Oddi dysfunction. Management often involves endoscopic retrograde cholangiopancreatography (ERCP) with manometry and sphincterotomy. OBJECTIVE: To determine whether endoscopic sphincterotomy reduces pain and whether sphincter manometric pressure is predictive of pain relief. DESIGN, SETTING, AND PATIENTS: Multicenter, sham-controlled, randomized trial involving 214 patients with pain after cholecystectomy without significant abnormalities on imaging or laboratory studies, and no prior sphincter treatment or pancreatitis randomly assigned (August 6, 2008-March 23, 2012) to undergo sphincterotomy or sham therapy at 7 referral medical centers...
May 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/24751914/diagnosis-and-treatment-of-narcotic-bowel-syndrome
#18
REVIEW
Jacob E Kurlander, Douglas A Drossman
With increased prescription of opioids has come increased recognition of adverse consequences, including narcotic bowel syndrome (NBS). Characterized by incompletely controlled abdominal pain despite continued or increasing doses of opioids, NBS is estimated to occur in 4.2-6.4% of patients chronically taking opioids. Patients with NBS have a high degree of comorbid psychiatric illness, catastrophizing and disability; comorbid substance abuse must also be considered among this population. NBS should be distinguished from opioid-induced bowel disorder, which results from the effects of opioids on gastrointestinal motility and secretion...
July 2014: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/24714103/treatment-of-residual-inflammatory-bowel-disease-symptoms-with-low-dose-tricyclic-antidepressants-why-not
#19
EDITORIAL
Douglas A Drossman
No abstract text is available yet for this article.
May 2014: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/24472759/can-patient-and-pain-characteristics-predict-manometric-sphincter-of-oddi-dysfunction-in-patients-with-clinically-suspected-sphincter-of-oddi-dysfunction
#20
RANDOMIZED CONTROLLED TRIAL
Joseph Romagnuolo, Peter B Cotton, Valerie Durkalski, Qi Pauls, Olga Brawman-Mintzer, Douglas A Drossman, Patrick Mauldin, Kyle Orrell, April W Williams, Evan L Fogel, Paul R Tarnasky, Giuseppe Aliperti, Martin L Freeman, Richard A Kozarek, Priya A Jamidar, C Mel Wilcox, Jose Serrano, Grace H Elta
BACKGROUND: Biliopancreatic-type postcholecystectomy pain, without significant abnormalities on imaging and laboratory test results, has been categorized as "suspected" sphincter of Oddi dysfunction (SOD) type III. Clinical predictors of "manometric" SOD are important to avoid unnecessary ERCP, but are unknown. OBJECTIVE: To assess which clinical factors are associated with abnormal sphincter of Oddi manometry (SOM). DESIGN: Prospective, cross-sectional...
May 2014: Gastrointestinal Endoscopy
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