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https://www.readbyqxmd.com/read/28351060/blood-pressure-variability-in-obstructive-sleep-apnoea-data-from-4-randomised-controlled-cpap-withdrawal-trials
#1
Franziska Lettau, Esther I Schwarz, John R Stradling, Malcolm Kohler
BACKGROUND: Increased daytime blood pressure variability (BPV) is associated with cardiovascular risk. Preliminary data suggest that obstructive sleep apnoea (OSA) might contribute to increased daytime BPV. OBJECTIVE: The aim of this study was to evaluate the effect of continuous positive airway pressure (CPAP) therapy withdrawal on daytime BPV. METHODS: A total of 183 patients previously diagnosed with OSA and treated with CPAP were randomised to either continue or withdraw from CPAP within 4 trials...
March 29, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28350990/the-putative-drp1-inhibitor-mdivi-1-is-a-reversible-mitochondrial-complex-i-inhibitor-that-modulates-reactive-oxygen-species
#2
Evan A Bordt, Pascaline Clerc, Brian A Roelofs, Andrew J Saladino, László Tretter, Vera Adam-Vizi, Edward Cherok, Ahmed Khalil, Nagendra Yadava, Shealinna X Ge, T Chase Francis, Nolan W Kennedy, Lora K Picton, Tanya Kumar, Sruti Uppuluri, Alexandrea M Miller, Kie Itoh, Mariusz Karbowski, Hiromi Sesaki, R Blake Hill, Brian M Polster
Mitochondrial fission mediated by the GTPase dynamin-related protein 1 (Drp1) is an attractive drug target in numerous maladies that range from heart disease to neurodegenerative disorders. The compound mdivi-1 is widely reported to inhibit Drp1-dependent fission, elongate mitochondria, and mitigate brain injury. Here, we show that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e...
March 27, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28350969/mechanisms-of-spontaneous-pacing-sa-nodal-cells-neonatal-cardiomyocytes-and-human-stem-cell-derived-cardiomyocytes
#3
Martin Morad, Xiaohua Zhang
The sino-atrial node is the primary site from which the mammalian heart is paced, but the mechanisms underlying the pacemaking still remain clouded. It is generally believed that the hyperpolarization-activated current I<sub><i>f</i></sub>, encoded by Hyperpolarization-activated cyclic nucleotide-gated (HCN) genes, contributes significantly to pacing, which in tandem with inward current generated by efflux of Ca<sup>2+</sup> via the Na<sup>+</sup>-Ca<sup>2+</sup> exchanger (NCX), resulting from the released Ca<sup>2+</sup>, mediates the diastolic depolarization...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350967/molecular-hydrogen-potentiates-beneficial-anti-infarct-effect-of-hypoxic-postconditioning-in-isolated-rat-hearts-novel-cardioprotective-intervention
#4
Marek Zálešák, Branislav Kura, Ján Graban, Veronika Ledvényiová-Farkašová, Jan Slezak, Tatiana Ravingerova
Generation of free radicals through incomplete reduction of oxygen during ischemia/ reperfusion is well-described. On the other hand, molecular hydrogen (H<sub>2</sub>) reduces oxidative stress due to its ability to react with strong oxidants and easily penetrate cells by diffusion, without disturbing metabolic redox reactions. This study was designed to explore cardioprotective potential of hypoxic postconditioning (HpostC) against ischemia/reperfusion (30-min global I/120-min R) in isolated rat hearts using oxygen-free Krebs-Henseleit buffer (KHB)...
March 28, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350861/efficacy-and-effects-on-cardiac-function-of-radiofrequency-catheter-ablation-vs-direct-current-cardioversion-of-persistent-atrial-fibrillation-with-left-ventricular-systolic-dysfunction
#5
Maojing Wang, Shanglang Cai, Wei Ding, Yujie Deng, Qing Zhao
OBJECTIVE: To evaluate the effect of catheter ablation vs. direct current synchronized cardioversion (DCC) in patients with persistent atrial fibrillation (AF) and left ventricular systolic dysfunction, and to define baseline features of patients that will get more benefit from ablation. METHODS: From July 2013 to October 2014, 97 consecutive single-center patients with persistent AF and symptomatic heart failure (left ventricular ejection fraction (LVEF) <50%) underwent DCC followed by amiodarone (n = 40) or circumferential pulmonary vein isolation (PVI; n = 57) according to patient's preference were recruited in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28350818/effects-and-mechanisms-of-auricular-electroacupuncture-on-gastric-hypersensitivity-in-a-rodent-model-of-functional-dyspepsia
#6
Jingzhu Zhou, Shiying Li, Yinping Wang, Yong Lei, Robert D Foreman, Jieyun Yin, Jiande D Z Chen
BACKGROUND: Functional dyspepsia (FD) is a common functional gastrointestinal disease, and abdominal pain is one of the main symptoms. The aim of this study was to explore the effects and mechanisms of auricular electro-acupuncture (AEA) on gastric hypersensitivity in a rodent model of FD. METHODS: Ten-day-old pups were gavaged with 0.2 ml of 0.1% iodoacetamide daily for 6 days. AEA at the "stomach" point with different parameters or sham-EA was performed on 8-week-old animals...
2017: PloS One
https://www.readbyqxmd.com/read/28350766/cardiac-autonomic-system-response-to-submaximal-test-in-children-with-cerebral-palsy
#7
Taly Amichai, Sharon Eylon, Horesh Dor-Haim, Itai Berger, Michal Katz-Leurer
AIM: To describe the heart rate (HR) and heart rate variability at rest, during a submaximal treadmill test and at rest posttreadmill in children with cerebral palsy (CP). METHODS: Twenty children (6-11 years) with CP participated, who had Gross Motor Function Classification System levels I to III. The HR was monitored for 5 minutes seated, during a submaximal treadmill test, and after 5 minutes rest posttreadmill. Outcome variables were HR and the square root of the mean squared differences of successive differences between adjacent heart beats (RMSSD)...
April 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28350721/a-rare-case-of-cor-triatriatum-leading-to-respiratory-failure-and-shock-in-an-8-month-old
#8
Catherine Burger
An 8-month-old boy presents with 1 week of gradually worsening respiratory distress. After chest radiograph shows bilateral airspace opacities, he is treated for pneumonia with antibiotics and intravenous fluids. Shortly after this, he decompensates requiring intubation, followed by cardiopulmonary support with pressors and eventually extracorporeal membrane oxygenation. Bedside ultrasound then shows an additional congenital membrane in the left atrium obstructing pulmonary venous return and thought to have caused his original presentation and subsequent decompensation...
March 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28350715/continuous-cardiac-autonomic-and-haemodynamic-responses-to-isometric-exercise
#9
Katrina A Taylor, Jonathan D Wiles, Damian D Coleman, Rajan Sharma, Jamie M O'Driscoll
PURPOSE: Elevated arterial blood pressure (BP) is associated with autonomic dysfunction and impaired haemodynamic control mechanisms. Isometric exercise (IE) training has been demonstrated effective at reducing BP; however, the continuous cardiovascular responses during IE are underinvestigated. We hypothesized that reflex autonomic cardiovascular control is an important mediator in reducing BP. To test our hypothesis, we investigated continuous cardiac autonomic modulation and baroreceptor reflex sensitivity (BRS) in response to IE...
March 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28350713/sex-specific-maximum-predicted-heart-rate-and-its-prognosis-for-mortality-and-mi
#10
Haitham M Ahmed, Mouaz H Al-Mallah, Steven J Keteyian, Clinton A Brawner, Jonathan K Ehrman, Di Zhao, Eliseo Guallar, Michael J Blaha, Erin D Michos
PURPOSE: Maximum predicted heart rate (MPHR) is traditionally calculated by (220-Age). However, this formula's validity has been questioned in women. The purpose of this study was to derive sex-specific formulas for MPHR in a clinical population, and compare their prognostic significance to the traditional formula. METHODS: This was a retrospective cohort of adults referred for exercise treadmill testing (ETT) between 1991 and 2009. Peak heart rate versus age was plotted by sex, and linear regression analysis was used to derive sex-specific MPHR formulas...
March 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28350711/physical-activity-and-lifetime-risk-of-cardiovascular-disease-and-cancer
#11
Yasuhiko Kubota, Kelly R Evenson, Richard F MacLehose, Nicholas S Roetker, Corinne E Joshu, Aaron R Folsom
PURPOSE: Although the World Health Organization (WHO) has recommended moderate- to vigorous-intensity physical activity (MVPA) to prevent cardiovascular disease (CVD) and some cancers, there are no estimates of lifetime risk of these non-communicable diseases according to PA levels. We aimed to estimate the lifetime risk of CVD and cancers according to PA levels. METHODS: We followed 5,807 men and 7,252 women in the U.S. age 45-64 initially free of CVD and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of CVD (coronary heart disease, heart failure and stroke) and total cancer according to PA levels: poor (0 minutes/week of MVPA), intermediate (1-74 minutes/week of VPA or 1-149 minutes/week of MVPA) or recommended (≥75 minutes/week of VPA or ≥150 minutes/week of MVPA)...
March 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28350703/rf-safety-analysis-of-a-novel-ultra-wideband-fetal-monitoring-system
#12
Jerrold T Bushberg, J Paul Tupin
The LifeWave Ultra-Wideband RF sensor (LWUWBS) is a monitoring solution for a variety of physiologic assessment applications, including maternal fetal monitoring in both the antepartum and intrapartum periods. The system uses extremely low power radio frequency (RF) ultra-wide band (UWB) signals to provide continuous fetal heart rate and contractions monitoring during labor and delivery. Even with the incorporation of three very conservative assumptions, (1) concentration of the RF energy in 1 cm, (2) minimal (2...
May 2017: Health Physics
https://www.readbyqxmd.com/read/28350635/evidence-on-the-validity-of-a-comprehensive-health-risk-index-and-implications-for-ambulatory-care-and-population-health-management
#13
Joseph M Massaro, Joanne M Murabito, Rhoda Au, Emily Carnahan, Tamara S Morgan, Christopher Murray, Elliott S Fisher, Eugene C Nelson, Stephen S Lim, Ralph B DʼAgostino
A novel, comprehensive health risk index for adults has been validated and is now ready for use to improve the health of individuals and populations. This health risk index provides an estimate of the avoidable risk of death for adults 30 years or older. It includes 12 evidence-based clinical and behavioral risk factors and was validated on discrimination and calibration using the NHANES (National Health and Nutrition Examination Survey) and Framingham Heart Study cohorts. The results from both cohorts were consistent and similar...
March 27, 2017: Journal of Ambulatory Care Management
https://www.readbyqxmd.com/read/28350620/treatment-of-uncomplicated-hypertension-is-associated-with-a-reduction-in-cardiovascular-mortality-a-korean-national-cohort-study
#14
Chan J Lee, Jinseub Hwang, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Hyeon-Chang Kim, Sungha Park
BACKGROUND: Although the benefit of hypertension treatment is well established in high-risk patients, there is a paucity of evidence regarding the benefit of treatment in patients with uncomplicated hypertension. METHODS: Hypertensive adult patients were selected from the Korea National Health Insurance Sample Cohort in 2002 and were followed until 2013. Patients with a diagnosis of heart failure, coronary artery disease, stroke, malignancy, diabetes, or chronic kidney disease were excluded...
May 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28350577/reliability-of-heart-rate-as-neuroadrenergic-marker-in-the-metabolic-syndrome
#15
Fosca Quarti Trevano, Gino Seravalle, Mario Macchiarulo, Paolo Villa, Carlo Valena, Raffaella Dell'Oro, Giuseppe Mancia, Guido Grassi
BACKGROUND: Metabolic syndrome is characterized by a pronounced sympathetic overactivity as documented by the marked increase in muscle sympathetic nerve traffic (MSNA) as well as in plasma norepinephrine values reported in this condition. Whether and to what extent heart rate (HR) reflects the abovementioned adrenergic alterations in metabolic syndrome remains largely undefined. It is also undefined the validity of the abovementioned adrenergic markers in reflecting the main features of the metabolic syndrome...
March 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28350541/computational-hybrid-anthropometric-paediatric-phantom-library-for-internal-radiation-dosimetry
#16
Tianwu Xie, Niels Kuster, Habib Zaidi
Hybrid computational phantoms combine voxel-based and simplified equation-based modelling approaches to provide unique advantages and more realism for the construction of anthropomorphic models. In this work, a methodology and C++ code are developed to generate hybrid computational phantoms covering statistical distributions of body morphometry in the paediatric population. The paediatric phantoms of the Virtual Population Series (IT'IS Foundation, Switzerland) were modified to match target anthropometric parameters, including body mass, body length, standing height and sitting height/stature ratio, determined from reference databases of the National Centre for Health Statistics and the National Health and Nutrition Examination Survey...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28350537/comparison-of-structured-and-unstructured-physical-activity-training-on-predicted-vo2max-and-heart-rate-variability-in-adolescents-a-randomized-control-trial
#17
Vivek Kumar Sharma, Senthil Kumar Subramanian, Krishnakumar Radhakrishnan, Rajathi Rajendran, Balasubramanian Sulur Ravindran, Vinayathan Arunachalam
BACKGROUND: Physical inactivity contributes to many health issues. The WHO-recommended physical activity for adolescents encompasses aerobic, resistance, and bone strengthening exercises aimed at achieving health-related physical fitness. Heart rate variability (HRV) and maximal aerobic capacity (VO2max) are considered as noninvasive measures of cardiovascular health. The objective of this study is to compare the effect of structured and unstructured physical training on maximal aerobic capacity and HRV among adolescents...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28346975/hypothyroidism-is-associated-with-all-cause-mortality-in-a-national-cohort-of-chronic-hemodialysis-patients
#18
Hsuan-Jen Lin, Chung-Chih Lin, Hsuan Ming Lin, Hsuan-Ju Chen, Che-Chen Lin, Chiz-Tzung Chang, Che-Yi Chou, Chiu-Ching Huang
BACKGROUND: The prevalence of hypothyroidism is high in hemodialysis (HD) patients and hypothyroidism increases all-cause mortality in HD patients. Comorbidities are common in HD patients and are associated with both mortality and hypothyroidism. The aim of the study is to explore the effect of the interactions of comorbidities and hypothyroidism on all-cause mortality in HD patients. METHOD: Patients with hypothyroidism (ICD-9-CM 244.0, 244.1, and 244.9) and matched patients without hypothyroidism in the Registry for Catastrophic Illness Patient Database of Taiwan Health Insurance from 2000 to 2010 were analyzed...
March 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28346857/the-influence-of-epicardial-fat-and-nonalcoholic-fatty-liver-disease-on-heart-rate-recovery-in-metabolic-syndrome
#19
Kyoung Im Cho, Eun Ah Jo, Sang Hoon Cho, Bo Hyun Kim
BACKGROUND: Epicardial adipose tissues reflecting visceral fat accumulations of the heart are associated with metabolic syndrome (MetS) and can be a predictor of other cardiometabolic diseases. It can adversely influence autonomic nervous system (ANS) of heart. Heart rate recovery (HRR) is an easy method for measuring ANS dysfunction. The purpose of this study was to determine whether epicardial fat thickness (EFT) and nonalcoholic fatty liver disease (NAFLD) are related to HRR in patients with MetS...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346848/cardiovascular-protective-effects-and-clinical-applications-of-resveratrol
#20
Sanghyun Cho, Kyung Namkoong, Minji Shin, Jueun Park, Eunyeong Yang, Jinsoo Ihm, Vu Thi Thu, Hyoung Kyu Kim, Jin Han
Resveratrol is a naturally occurring phenol that is generated by plant species following injury or attack by bacterial and fungal pathogens. This compound was first described as the French Paradox in 1992. Later in 2003, resveratrol was reported to activate sirtuins in yeast cells. Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span...
March 27, 2017: Journal of Medicinal Food
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