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Hiske J Brouwer, Marc C Den Heijer, Bernard P Paelinck, Philippe Debonnaire, Marc Vanderheyden, Caroline M Van De Heyning, Dina De Bock, Patrick Coussement, Georges Saad, Bert Ferdinande, Anne-Catherine Pouleur, Marc J Claeys
Aims: The effect of MitraClip implantation on left ventricular (LV) remodelling has been shown to be highly variable. The present study wants to assess patterns of LV remodelling and its relationship with outcome. Methods and results: Serial echocardiography before, 1 and 6 months after MitraClip implantation was performed in 79 pts with severe mitral regurgitation (MR) (age 74 ± 10 years, New York Heart Association III/IV 80%, LV ejection fraction 38 ± 13%, logistic EuroSCORE 21 ± 15, and functional MR 81%)...
July 11, 2018: European Heart Journal Cardiovascular Imaging
Wenjian Bi, Yun Li, Matthew P Smeltzer, Guimin Gao, Shengli Zhao, Guolian Kang
It has been well acknowledged that methods for secondary trait (ST) association analyses under a case-control design (ST$_{\text{CC}}$) should carefully consider the sampling process to avoid biased risk estimates. A similar situation also exists in the extreme phenotype sequencing (EPS) designs, which is to select subjects with extreme values of continuous primary phenotype for sequencing. EPS designs are commonly used in modern epidemiological and clinical studies such as the well-known National Heart, Lung, and Blood Institute Exome Sequencing Project...
July 11, 2018: Biostatistics
Selasi Attipoe, Liam Delahanty, Mark Stephens, Patricia A Deuster
Introduction: The use of energy drinks (ED) or shots (ES) is becoming increasingly popular in U.S. beverage market. In addition, young, physically active males, such as active-duty enlistees represent a prime target for the advertising of ED/ES; however, the exact mechanisms and safety of these products have come under scrutiny. This cross-sectional, exploratory, web-based survey among U.S. service members describes the prevalence of ED/ES use as well as common side effects and safety of these products among self-reported users...
July 11, 2018: Military Medicine
Marcia C de Oliveira Otto, Rozenn N Lemaitre, Xiaoling Song, Irena B King, David S Siscovick, Dariush Mozaffarian
Background: Controversy has emerged about the benefits compared with harms of dairy fat, including concerns over long-term effects. Previous observational studies have assessed self-reported estimates of consumption or a single biomarker measure at baseline, which may lead to suboptimal estimation of true risk. Objective: The aim of this study was to investigate prospective associations of serial measures of plasma phospholipid fatty acids pentadecanoic (15:0), heptadecanoic (17:0), and trans-palmitoleic (trans-16:1n-7) acids with total mortality, cause-specific mortality, and cardiovascular disease (CVD) risk among older adults...
July 11, 2018: American Journal of Clinical Nutrition
Esther Gil-Barrionuevo, José Maria Balibrea, Enric Caubet, Oscar Gonzalez, Ramón Vilallonga, José Manuel Fort, Andrea Ciudin, Manel Armengol
INTRODUCTION: Pheochromocytomas are infrequent tumors arised from the chromaphine cells of the adrenal sympathetic system. The excess of circulating catecholamines may lead to different cardiovascular disorders from silent alterations of the myocardial conduction to different forms of cardiomyopathy. The onset as cardiogenic shock is exceptional. PRESENTATION OF CASE: A 35-year-old male, with a known history of acute myopericarditis of unknown origin which debuted as acute pulmonary edema, was admitted with dyspnea in the context of a new heart failure episode with pulmonary edema...
June 27, 2018: International Journal of Surgery Case Reports
Adam Sacarny
Performance-raising practices tend to diffuse slowly in the health care sector. To understand how incentives drive adoption, I study a practice that generates revenue for hospitals: submitting detailed documentation about patients. After a 2008 reform, hospitals could raise their Medicare revenue over 2% by always specifying a patient's type of heart failure. Hospitals only captured around half of this revenue, indicating that large frictions impeded takeup. Exploiting the fact that many doctors practice at multiple hospitals, I find that four-fifths of the dispersion in adoption reflects differences in the ability of hospitals to extract documentation from physicians...
June 19, 2018: Journal of Health Economics
Alessio Paolini, Salim Abdelilah-Seyfried
Over a lifetime, rhythmic contractions of the heart provide a continuous flow of blood throughout the body. An essential morphogenetic process during cardiac development which ensures unidirectional blood flow is the formation of cardiac valves. These structures are largely composed of extracellular matrix and of endocardial cells, a specialized population of endothelial cells that line the interior of the heart and that are subjected to changing hemodynamic forces. Recent studies have significantly expanded our understanding of this morphogenetic process...
July 11, 2018: Current Opinion in Cell Biology
Aaron R Folsom, Pamela L Lutsey, Susan R Heckbert, Kripa Poudel, Saonli Basu, Ron C Hoogeveen, Mary Cushman, Christie M Ballantyne
BACKGROUND: We previously showed that participants in the population-based Atherosclerosis Risk in Communities (ARIC) cohort with elevated blood biomarkers of inflammation or cardiac disease were at increased risk of venous thromboembolism (VTE). OBJECTIVE: We hypothesized now that ARIC participants with larger 6-year increases in three biomarkers - C-reactive protein (CRP), N-terminal pro B-type natriuretic peptide (NT-proBNP), and troponin T - also would have increased subsequent risk of VTE...
July 14, 2018: Journal of Thrombosis and Haemostasis: JTH
Lucas Barretto-de-Souza, Mariane B Adami, Ricardo Benini, Carlos C Crestani
BACKGROUND AND PURPOSE: The aim of the present study was to assess the interaction of nitrergic neurotransmission within the bed nucleus of the stria terminalis (BNST) with local glutamatergic and noradrenergic neurotransmission in the control of cardiovascular responses to acute restraint stress in rats. EXPERIMENTAL APPROACH: Interaction with local noradrenergic neurotransmission was evaluated by investigating the effect of local pretreatment with the selective α1 -adrenoceptor antagonist WB4101 before microinjection of the nitric oxide donor NOC-9 into the BNST...
July 14, 2018: British Journal of Pharmacology
M N Zamotaeva, V I Inchina, V V Konorev, Yu V Kuznetsov, N D Kuz'michev
The possibility of correction of morphological changes in the myocardium and biochemical parameters of the blood with 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg was studied in the model of doxorubicin-induced chronic heart failure in rats. It was found that 3-hydroxypyridine acetylcysteinate in a dose of 25 mg/kg produced less pronounced cardio-protective effect in experimental chronic heart failure than 3-hydroxypyridine succinate.
July 13, 2018: Bulletin of Experimental Biology and Medicine
Zinais Kontouli, Chryssoula Staikou, Nicoletta Iacovidou, Ioannis Mamais, Evaggelia Kouskouni, Apostolos Papalois, Panagiotis Papapanagiotou, Anil Gulati, Athanasios Chalkias, Theodoros Xanthos
PURPOSE: To investigate the effects of the combination of centhaquin and 6% hydroxyethyl starch 130/0.4 (HES 130/0.4) in a swine model of hemorrhagic shock. METHODS: Twenty Landrace-Large White pigs were instrumented and subjected to hemorrhagic shock. The animals were randomly allocated in two experimental groups, the control (group CO, n = 10) and the centhaquin groups (0.015 mg/kg, n = 10, group CH). Acute hemorrhage was induced by stepwise blood withdrawal (18 mL/min) from the internal jugular vein until MAP decreased to 40-45 mmHg, whereas anesthesia remained constant...
July 13, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
Katherine E Bathgate, James R Bagley, Edward Jo, Robert J Talmadge, Irene S Tobias, Lee E Brown, Jared W Coburn, Jose A Arevalo, Nancy L Segal, Andrew J Galpin
INTRODUCTION: Physical health and function depend upon both genetic inheritance and environmental factors (e.g., exercise training). PURPOSE: To enhance the understanding of heritability/adaptability, we explored the skeletal muscle health and physiological performance of monozygotic (MZ) twins with > 30 years of chronic endurance training vs. no specific/consistent exercise. METHODS: One pair of male MZ twins (age = 52 years; Trained Twin, TT; Untrained Twin, UT) underwent analyses of: (1) anthropometric characteristics and blood profiles, (2) markers of cardiovascular and pulmonary health, and (3) skeletal muscle size, strength, and power and molecular markers of muscle health...
July 14, 2018: European Journal of Applied Physiology
Xiuying Wang, Hui Cui, Guanzhong Gong, Zheng Fu, Jianlong Zhou, Jiabing Gu, Yong Yin, Dagan Feng
Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity measurement of the lung tumor for dose-escalation. For tumor delineation, our algorithm firstly separates the tumor from its adjacent high-uptake tissues using 3D projection masks; then the tumor boundary is delineated with our stopping criterion of joint gradient and intensity affinities...
July 13, 2018: Scientific Reports
Tanja Vajen, Rory R Koenen, Isabella Werner, Mareike Staudt, Delia Projahn, Adelina Curaj, Tolga Taha Sönmez, Sakine Simsekyilmaz, David Schumacher, Julia Möllmann, Tilman M Hackeng, Philipp von Hundelshausen, Christian Weber, Elisa A Liehn
Myocardial infarction (MI) is a major cause of death in Western countries and finding new strategies for its prevention and treatment is thus of high priority. In a previous study, we have demonstrated a pathophysiologic relevance for the heterophilic interaction of CCL5 and CXCL4 in the progression of atherosclerosis. A specifically designed compound (MKEY) to block this CCL5-CXCR4 interaction is investigated as a potential therapeutic in a model of myocardial ischemia/reperfusion (I/R) damage. 8 week-old male C57BL/6 mice were intravenously treated with MKEY or scrambled control (sMKEY) from 1 day before, until up to 7 days after I/R...
July 13, 2018: Scientific Reports
Yan Chen, Ying-Xian Liu, Wai-Kay Seto, Mei-Zhen Wu, Yu-Juan Yu, Yui-Ming Lam, Wing-Kuk Au, Daniel Chan, Ko-Yung Sit, Lai-Ming Ho, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: The Model for End-stage Liver Disease excluding international normalized ratio (MELD-XI) score and the modified MELD score with albumin replacing international normalized ratio (MELD-Albumin) score, which reflect both liver and renal function, have been reported as predictors of adverse events in liver and heart disease. Nonetheless, their prognostic value in patients undergoing tricuspid annuloplasty has not been addressed. METHODS AND RESULTS: A total of 394 patients who underwent tricuspid annuloplasty were evaluated...
July 13, 2018: Journal of the American Heart Association
Jennifer E Ho, Asya Lyass, Paul Courchesne, George Chen, Chunyu Liu, Xiaoyan Yin, Shih-Jen Hwang, Joseph M Massaro, Martin G Larson, Daniel Levy
BACKGROUND: The discovery of novel and highly predictive biomarkers of cardiovascular disease (CVD) has the potential to improve risk-stratification methods and may be informative regarding biological pathways contributing to disease. METHODS AND RESULTS: We used a discovery proteomic platform that targeted high-value proteins for CVD to ascertain 85 circulating protein biomarkers in 3523 Framingham Heart Study participants (mean age, 62 years; 53% women). Using multivariable-adjusted Cox models to account for clinical variables, we found 8 biomarkers associated with incident atherosclerotic CVD, 18 with incident heart failure, 38 with all-cause mortality, and 35 with CVD death (false discovery rate, q<0...
July 13, 2018: Journal of the American Heart Association
Naghum Alfulaij, Franziska Meiners, Justin Michalek, Andrea L Small-Howard, Helen C Turner, Alexander J Stokes
No abstract text is available yet for this article.
July 13, 2018: Journal of the American Heart Association
Trisha V Vigneswaran, Ranjit Akolekar, Argyro Syngelaki, Marietta Charakida, Lindsey D Allan, Kypros H Nicolaides, Vita Zidere, John M Simpson
BACKGROUND: Assessment of the outflow tract views is an integral part of routine fetal cardiac scanning. For some congenital heart defects, notably coarctation of the aorta, pulmonary valve stenosis, and aortic valve stenosis, the size of vessels is important both for diagnosis and prognosis. Existing reference ranges of fetal outflow tracts are derived from a small number of cases. METHODS AND RESULTS: The study population comprised 7945 fetuses at 13 to 36 weeks' gestation with no detectable abnormalities from pregnancies resulting in normal live births...
July 2018: Circulation. Cardiovascular Imaging
Xiaohua You, Zhi-Fu Guo, Fang Cheng, Bing Yi, Fan Yang, Xinzhu Liu, Ni Zhu, Xianxian Zhao, Guijun Yan, Xin-Liang Ma, Jianxin Sun
The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators...
July 13, 2018: Journal of Biological Chemistry
Jie-Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang, Jae Hoon Moon
BACKGROUND: Symptoms and signs of thyrotoxicosis are nonspecific and assessing its clinical status is difficult with conventional physical examinations and history taking. Increased heart rate (HR) is one of the easiest signs to quantify this, and current wearable devices can monitor HR. OBJECTIVE: We assessed the association between thyroid function and resting HR measured by a wearable activity tracker (WD-rHR) and evaluated the clinical feasibility of using this method in patients with thyrotoxicosis...
July 13, 2018: JMIR MHealth and UHealth
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