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JOURNAL ARTICLE
Vincent Thijs, Geoffrey C Cloud, Nigel Gilchrist, Brooke Parsons, Forum Tilvawala, Jan Ho, Lara Ruthnam, Vimal Stanislaus, Nikola Sprigg, Marion Walker, Philip M Bath, Leonid Churilov, Julie Bernhardt
RATIONALE: A large proportion of stroke survivors will have long-lasting, debilitating neurological impairments, yet few efficacious medical treatment options are available. Etanercept inhibits binding of tumor necrosis factor to its receptor and is used in the treatment of inflammatory conditions. Perispinal subcutaneous injection followed by a supine, head down position may bypass the blood brain barrier. In observational studies and one small randomized controlled trial the majority of patients showed improvement in multiple post stroke impairments...
April 27, 2024: European Stroke Journal
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JOURNAL ARTICLE
Sara Mazzucco, Linxin Li, Maria Assuncao Tuna, Peter M Rothwell
INTRODUCTION: Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors...
April 18, 2024: European Stroke Journal
#3
JOURNAL ARTICLE
Andrea Morotti, Qi Li, Jawed Nawabi, Giorgio Busto, Federico Mazzacane, Anna Cavallini, Ashkan Shoamanesh, Mauro Morassi, Frieder Schlunk, Laura Piccolo, Giacomo Urbinati, Debora Pezzini, Maurizio Paciaroni, Enrico Fainardi, Ilaria Casetta, Alessandro Padovani, Andrea Zini
BACKGROUND: Severe hematoma expansion (sHE) has the strongest impact on intracerebral hemorrhage (ICH) outcome. We investigated the predictors of sHE. METHODS: Retrospective analysis of ICH patients admitted at nine sites in Italy, Germany, China, and Canada. The following imaging features were analyzed: non-contrast CT (NCCT) hypodensities, heterogeneous density, blend sign, irregular shape, and CT angiography (CTA) spot sign. The outcome of interest was sHE, defined as volume increase >66% and/or >12...
April 16, 2024: European Stroke Journal
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JOURNAL ARTICLE
Alessandro Pezzini, Barbara Tarantino, Marialuisa Zedde, Simona Marcheselli, Giorgio Silvestrelli, Alfonso Ciccone, Maria Luisa DeLodovici, Lucia Princiotta Cariddi, Simone Vidale, Maurizio Paciaroni, Cristiano Azzini, Marina Padroni, Massimo Gamba, Mauro Magoni, Massimo Del Sette, Rossana Tassi, Ivo Giuseppe De Franco, Anna Cavallini, Rocco Salvatore Calabrò, Manuel Cappellari, Elisa Giorli, Giacomo Giacalone, Corrado Lodigiani, Mara Zenorini, Francesco Valletta, Gianni Cutillo, Guido Bonelli, Giorgia Abrignani, Paola Castellini, Antonio Genovese, Lilia Latte, Maria Claudia Trapasso, Chiara Ferraro, Francesco Piancatelli, Rosario Pascarella, Ilaria Grisendi, Federica Assenza, Manuela Napoli, Claudio Moratti, Maurizio Acampa, Mario Grassi
INTRODUCTION: It is unclear which patients with non-traumatic (spontaneous) intracerebral haemorrhage (ICH) are at risk of developing acute symptomatic seizures (provoked seizures occurring within the first week after stroke onset; early seizures, ES) and whether ES predispose to the occurrence of remote symptomatic seizures (unprovoked seizures occurring more than 1 week after stroke; post-stroke epilepsy, PSE) and long-term mortality. PATIENTS AND METHODS: In the setting of the Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) we examined the risk of ES and whether they predict the occurrence of PSE and all-cause mortality in a cohort of patients with first-ever spontaneous ICH and no previous history of epilepsy, consecutively hospitalized in 12 Italian neurological centers from 2002 to 2014...
April 16, 2024: European Stroke Journal
#5
JOURNAL ARTICLE
Abel Clemens Adriaan Sandmann, Marinus Abraham Kempeneers, René van den Berg, Dagmar Verbaan, William Peter Vandertop, Jonathan M Coutinho
INTRODUCTION: There is uncertainty whether patients with a cerebral cavernous malformation (CCM) should undergo conservative or surgical treatment, resulting in practice variation among hospitals. Our objective was to report clinical outcomes of patients with primarily conservatively managed CCMs. PATIENTS AND METHODS: This single-center cohort study included consecutive adult CCM patients, diagnosed in 2000-2023, who underwent conservative management as primary treatment strategy...
April 16, 2024: European Stroke Journal
#6
JOURNAL ARTICLE
Giovanni Merlino, Michele Romoli, Raffaele Ornello, Matteo Foschi, Caterina Del Regno, Francesco Toraldo, Alessandro Marè, Francesco Cordici, Alessio Trosi, Marco Longoni, Fedra Kuris, Yan Tereshko, Simone Lorenzut, Carolina Gentile, Francesco Janes, Francesco Bax, Massimo Sponza, Vladimir Gavrilovic, Soma Banerjee, Simona Sacco, Gian Luigi Gigli, Lucio D'Anna, Mariarosaria Valente
INTRODUCTION: Mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) due to anterior large vessel occlusion (LVO). Despite successful recanalization, some patients remain disabled after 3 months. Mechanisms that can cause futile recanalization (FR) are still largely unknown. We investigated if stress hyperglycemia might be associated with FR. PATIENTS AND METHODS: This is a retrospective analysis of consecutive patients with successful recanalization treated in four participating centers between January 2021 and December 2022...
April 16, 2024: European Stroke Journal
#7
JOURNAL ARTICLE
Inbar Nardi Agmon, Rani Barnea, Amos Levi, Omar Murad, Gideon Shafir, Jonathan Naftali, Nadav Schellekes, Arthur Shiyovich, Ran Kornowski, Eitan Auriel, Ashraf Hamdan
INTRODUCTION: Variations in the left atrial appendage (LAA) morphology are associated with different embolic risk in patients with atrial fibrillation (AF). Data are scarce regarding the association between LAA morphology and Embolic stroke of undetermined source (ESUS). PATIENTS AND METHODS: Using cardiac computed tomography (CCT) scans, LAA morphology was categorized as either chicken wing (CW), cactus, windsock, or cauliflower. Furthermore, we examined the presence of large secondary lobes arising from the main lobe, considering their existence as indicative of a complex LAA morphology...
April 14, 2024: European Stroke Journal
#8
JOURNAL ARTICLE
Menno R Germans, Maud A Tjerkstra, René Post, Amy Brenner, Mervyn DI Vergouwen, Gabriël Je Rinkel, Yvo Bwem Roos, René van den Berg, Bert A Coert, W Peter Vandertop, Dagmar Verbaan
INTRODUCTION: The ULTRA-trial investigated effectiveness of ultra-early administration of tranexamic acid (TXA) in subarachnoid hemorrhage (SAH) and showed that TXA reduces the risk of rebleeding without concurrent improvement in clinical outcome. Previous trials in bleeding conditions, distinct from SAH, have shown that time to start of antifibrinolytic treatment influences outcome. This post-hoc analysis of the ULTRA-trial investigates whether the interval between hemorrhage and start of TXA impacts the effect of TXA on rebleeding and functional outcome following aneurysmal SAH...
April 12, 2024: European Stroke Journal
#9
JOURNAL ARTICLE
Sine Mette Øgendahl Buus, Anne Brink Behrndtz, Marie Louise Schmitz, Jakob Nebeling Hedegaard, Pia Cordsen, Søren Paaske Johnsen, Thanh Phan, Grethe Andersen, Claus Ziegler Simonsen
INTRODUCTION: Rural residency has been associated with lower reperfusion treatment rates for acute ischemic stroke in many countries. We aimed to explore urban-rural differences in IV thrombolysis rates in a small country with universal health care, and short transport times to stroke units. PATIENTS AND METHODS: In this nationwide cohort study, adult ischemic stroke patients registered in the Danish Stroke Registry (DSR) between 2015 and 2020 were included. The exposure was defined by residence rurality...
April 10, 2024: European Stroke Journal
#10
JOURNAL ARTICLE
John J McCabe, Cathal Walsh, Sarah Gorey, Katie Harris, Pablo Hervella, Ramon Iglesias-Rey, Christina Jern, Linxin Li, Nobukazu Miyamoto, Joan Montaner, Annie Pedersen, Francisco Purroy, Peter M Rothwell, Catherine Sudlow, Yuji Ueno, Mikel Vicente-Pascual, William Whiteley, Mark Woodward, Peter J Kelly
INTRODUCTION: Inflammation is an emerging target for secondary prevention after stroke and randomised trials of anti-inflammatory therapies are ongoing. Fibrinogen, a putative pro-inflammatory marker, is associated with first stroke, but its association with major adverse cardiovascular events (MACE) after stroke is unclear. MATERIALS AND METHODS: We did a systematic review investigating the association between fibrinogen and post-stroke vascular recurrence. Authors were invited to provide individual-participant data (IPD) and where available we did within-study multivariable analyses with adjustment for cardiovascular risk factors and medications...
April 10, 2024: European Stroke Journal
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JOURNAL ARTICLE
Adrian Scutelnic, Anita van de Munckhof, Angel T Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco Grillo, Fabrizio Giammello, Thanh N Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S Kristoffersen, Johanna A Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M Coutinho, José M Ferro, Marcel Arnold, Mirjam R Heldner
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison...
April 4, 2024: European Stroke Journal
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JOURNAL ARTICLE
Hans-Christoph Diener, Gerrit M Grosse, Anika Hüsing, Andreas Stang, Nils Kuklik, Marcus Brinkmann, Gabriele D Maurer, Hassan Soda, Carsten Pohlmann, Rüdiger Hilker-Roggendorf, Nikola Popovic, Peter Kraft, Bruno-Marcel Mackert, Christoph C Eschenfelder, Christian Weimar
INTRODUCTION: Factor Xa (FXa) inhibitors are superior to vitamin K antagonists (VKAs) in terms of avoiding hemorrhagic complications. However, no robust data are available to date as to whether this also applies to the early phase after stroke. In this prospective registry study, we aimed to investigate whether anticoagulation with FXa inhibitors in the early phase after acute ischemic stroke or transient ischemic attack (TIA) is associated with a lower risk of major bleeding events compared with VKAs...
April 3, 2024: European Stroke Journal
#13
JOURNAL ARTICLE
Laura Abraira, Samuel López-Maza, Manuel Quintana, Elena Fonseca, Manuel Toledo, Daniel Campos-Fernández, Sofía Lallana, Laia Grau-López, Jordi Ciurans, Marta Jiménez, Juan Luis Becerra, Alejandro Bustamante, Marta Rubiera, Anna Penalba, Joan Montaner, José Álvarez Sabin, Estevo Santamarina
INTRODUCTION: In addition to clinical factors, blood-based biomarkers can provide useful information on the risk of developing post-stroke epilepsy (PSE). Our aim was to identify serum biomarkers at stroke onset that could contribute to predicting patients at higher risk of PSE. PATIENTS AND METHODS: From a previous study in which 895 acute stroke patients were followed-up, 51 patients developed PSE. We selected 15 patients with PSE and 15 controls without epilepsy...
April 1, 2024: European Stroke Journal
#14
JOURNAL ARTICLE
Karoliina Aarnio, Nicolas Martinez-Majander, Elena Haapaniemi, Eeva Kokkola, Jenna Broman, Lauri Tulkki, Markku Kaste, Turgut Tatlisumak, Jukka Putaala
INTRODUCTION: Scarce data exist on the etiology of recurrent ischemic strokes (ISs) among young adults. We analyzed the etiology of first-ever and recurrent events and the differences between them. PATIENTS AND METHODS: Patients aged 15-49 years with a first-ever IS in 1994-2007 were included in the Helsinki Young Stroke Registry. In this retrospective cohort study, data on recurrent ISs were identified from Care Register for Health Care until the end of 2017 and Causes of Death Register and from patient records until the end of 2020...
March 25, 2024: European Stroke Journal
#15
JOURNAL ARTICLE
Bernhard P Berghout, Robin Yr Camarasa, Dianne Hk Van Dam-Nolen, Aad van der Lugt, Marleen de Bruijne, Peter J Koudstaal, M Kamran Ikram, Daniel Bos
INTRODUCTION: The diagnostic workup of stroke doesn't identify an underlying cause in two-fifths of ischemic strokes. Intracranial arteriosclerosis is acknowledged as a cause of stroke in Asian and Black populations, but is underappreciated as such in whites. We explored the burden of Intracranial Artery Calcification (IAC), a marker of intracranial arteriosclerosis, as a potential cause of stroke among white patients with recent ischemic stroke or TIA. PATIENTS AND METHODS: Between December 2005 and October 2010, 943 patients (mean age 63...
March 20, 2024: European Stroke Journal
#16
JOURNAL ARTICLE
Marine Giroud, Mélanie Planton, Jean Darcourt, Nicolas Raposo, Pierre Brandicourt, Hélène Mirabel, Dominique Hervé, Alain Viguier, Jean-François Albucher, Jérémie Pariente, Jean Marc Olivot, Fabrice Bonneville, Patrice Péran, Lionel Calviere
INTRODUCTION: In Moyamoya angiopathy (MMA), mechanisms underlying cognitive impairment remain debated. We aimed to assess the association of cognitive impairment with the degree and the topography of cerebral hypoperfusion in MMA. METHODS: A retrospective analysis of neuropsychological and perfusion MRI data from adults with MMA was performed. Ischemic and haemorrhagic lesion masks were created to account for cerebral lesions in the analysis of cerebral perfusion...
March 19, 2024: European Stroke Journal
#17
JOURNAL ARTICLE
Tolga D Dittrich, Tennessee von Streng, Anna M Toebak, Annaelle Zietz, Benjamin Wagner, Martin Hänsel, Raoul Sutter, Mira Katan, Nils Peters, Lars Michels, Zsolt Kulcsár, Grzegorz M Karwacki, Marco Pileggi, Carlo W Cereda, Susanne Wegener, Leo H Bonati, Marios Psychogios, Gian Marco De Marchis
INTRODUCTION: The impact of leptomeningeal collateralization on the efficacy of mechanical thrombectomy (MT) in patients with anterior circulation large vessel occlusion (aLVO) presenting in the 6-24 h time window remains poorly elucidated. PATIENTS AND METHODS: Retrospective multicenter study of aLVO patients presenting between 6 and 24 h after stroke onset who received MT plus Best Medical Treatment (BMT) or BMT alone. Leptomeningeal collateralization was assessed using single-phase computed tomography angiography (grade 0: no filling; grade 1: filling ⩽50%; grade 2: filling >50% but <100%; grade 3: filling 100% of the occluded territory)...
March 18, 2024: European Stroke Journal
#18
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2024: European Stroke Journal
#19
JOURNAL ARTICLE
Adel Alhazzani, Fahad S Al-Ajlan, Ahmed Alkhiri, Ahmed A Almaghrabi, Aser F Alamri, Basil A Alghamdi, Hassan K Salamatullah, Abdullah R Alharbi, Maher B Almutairi, Hui-Sheng Chen, Yongjun Wang, Mohamad Abdalkader, Guillaume Turc, Pooja Khatri, Thanh N Nguyen
BACKGROUND: Minor ischemic stroke, defined as National Institute of Health Stroke Scale score of 0-5 on admission, represents half of all acute ischemic strokes. The role of intravenous alteplase (IVA) among patients with minor stroke is inconclusive; therefore, we evaluated clinical outcomes of these patients treated with or without IVA. MATERIALS AND METHODS: We searched Medline, Embase, Scopus, and the Cochrane library until August 1, 2023. Inclusion was restricted to the English literature of studies that reported on minor nondisabling stroke patients treated with or without IVA...
March 11, 2024: European Stroke Journal
#20
JOURNAL ARTICLE
Anne van der Meij, Ghislaine Holswilder, Marie Louise E Bernsen, Hendrikus Ja van Os, Jeannette Hofmeijer, Fianne Hm Spaander, Jasper M Martens, Ido R van den Wijngaard, Hester F Lingsma, Praneeta R Konduri, Charles Blm Majoie, Wouter J Schonewille, Diederik Wj Dippel, Nyika D Kruyt, Paul J Nederkoorn, Marianne Aa van Walderveen, Marieke Jh Wermer
INTRODUCTION: To improve our understanding of the relatively poor outcome after endovascular treatment (EVT) in women we assessed possible sex differences in baseline neuroimaging characteristics of acute ischemic stroke patients with large anterior vessel occlusion (LVO). PATIENTS AND METHODS: We included all consecutive patients from the MR CLEAN Registry who underwent EVT between 2014 and 2017. On baseline non-contrast CT and CT angiography, we assessed clot location and clot burden score (CBS), vessel characteristics (presence of atherosclerosis, tortuosity, size, and collateral status), and tissue characteristics with the Alberta Stroke Program Early Computed Tomography Score (ASPECTS)...
February 29, 2024: European Stroke Journal
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