Gerard R Hall, Frances Hutchings, Jonathan Horsley, Callum M Simpson, Yujiang Wang, Jane de Tisi, Anna Miserocchi, Andrew W McEvoy, Sjoerd B Vos, Gavin P Winston, John S Duncan, Peter N Taylor
Extra temporal lobe epilepsy (eTLE) may involve heterogenous widespread cerebral networks. We investigated the structural network of an eTLE cohort, at the postulated epileptogenic zone later surgically removed, as a network node: the resection zone (RZ). We hypothesized patients with an abnormal connection to/from the RZ to have proportionally increased abnormalities based on topological proximity to the RZ, in addition to poorer post-operative seizure outcome. Structural and diffusion MRI were collected for 22 eTLE patients pre- and post-surgery, and for 29 healthy controls...
2023: Network Neuroscience