Sandra Carrillo-Ibarra, Alejandra Guillermina Miranda-Díaz, Sonia Sifuentes-Franco, Ernesto Germán Cardona-Muñoz, Adolfo Daniel Rodríguez-Carrizalez, Geannyne Villegas-Rivera, Luis Miguel Román-Pintos
Oxidative stress induces nerve damage in type 2 diabetes mellitus and leads to diabetic polyneuropathy (DPN) and can affect the DNA and antioxidant status. Statins have pleiotropic, protective effects on the peripheral nerves of patients with diabetes. The aim of this study was to determine the effects of ezetimibe/simvastatin and rosuvastatin on DNA damage in patients with DPN. This randomized, double-blind, placebo-controlled, clinical trial comprised outpatients from Guadalajara, Mexico. The inclusion criteria were either gender, age 35-80 years, type 2 diabetes, glycated hemoglobin ≤10%, diabetic polyneuropathy stage 1/2, and signed informed consent...
January 2018: Journal of Circulating Biomarkers