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Clinical and Experimental Hepatology

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https://www.readbyqxmd.com/read/29904727/retreatment-of-symptomatic-hepatitis-c-virus-genotype-3-associated-mixed-cryoglobulinemia-with-sofosbuvir-and-ribavirin-a-case-report
#1
Dorota Zarębska-Michaluk, Piotr M Stępień, Katarzyna Paluch, Paweł Pabjan
A 52-year-old woman with chronic hepatitis C virus genotype 3 infection developed clinically symptomatic mixed cryoglobulinemia. She started pegylated interferon and ribavirin therapy and in week 12 became negative for HCV RNA with resolution of clinical signs of cryoglobulinemia. The dual treatment was discontinued due to interferon-related bilateral retinopathy. After therapy cessation, relapse of HCV RNA and recurrence of symptomatic cryoglobulinemia were observed. While waiting for the antiviral retreatment option she developed glomerulonephritis with renal impairment...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904726/sx-ella-danis-stent-in-massive-upper-gastrointestinal-bleeding-in-cirrhosis-a-case-series
#2
Mayank Jain, Mahadevan Balkrishanan, Chenduran Snk, Sridhar Cgs, Ravi Ramakrishnan, Jayanthi Venkataraman
We report our experience of three cases of decompensated cirrhosis with massive upper gastrointestinal bleeding, which required insertion of an SX-Ella Danis stent for hemostasis. The procedure is safe and effective.
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904725/serum-level-of-interleukin-13-receptor-alpha-2-in-infants-with-biliary-atresia-is-it-of-value
#3
Nermin Adawy, Hanaa El-Araby, Alif Allam, Soha Elshenawy, Mohammed Khedr, Yasmine Ibrahim, Haidy M Zakaria
Aim of the study: We aimed to assess the utility of serum level IL-13Rα2 receptors as a non-invasive marker for early diagnosis of biliary atresia (BA) and selection of BA patients indicated for Kasai portoenterostomy. Material and methods: The study included 60 infants with neonatal cholestasis in three groups; early BA group ( n = 20), delayed BA group ( n = 20) and non-BA cholestasis group ( n = 20). A fourth group of 20 healthy neonates ( n = 20) served as controls...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904724/ombitasvir-paritaprevir-ritonavir-dasabuvir-ribavirin-in-hcv-genotype-1-infected-patients-who-failed-previous-protease-inhibitor-therapy
#4
Béla Hunyady, Margit Abonyi, Zsuzsanna Gerlei, Judit Gervain, Gábor Horváth, Viktor Jancsik, Gabriella Lengyel, Erzsébet Makkai, Alajos Pár, Zoltán Péter, Margit Pusztay, Pál Ribiczey, László Rókusz, Christoph Sarrazin, Ferenc Schneider, Simone Susser, Ferenc Szalay, István Tornai, Anna Tusnádi, Eszter Újhelyi, Klára Werling, Mihály Makara
Aim of the study: Combination of ombitasvir/paritaprevir/ritonavir + dasabuvir ± ribavirin (3DDA±RBV) therapy is shown to be effective in HCV genotype 1 (GT1) infected patients. However, sparse data exist in patients who failed previous boceprevir or telaprevir based therapies. Real life efficacy and safety of this combination were evaluated in HCV GT1b infected patients (mostly cirrhotics) with compensated liver disease who failed previous boceprevir or telaprevir based therapies more than a year before...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904723/taurine-supplementation-abates-cirrhosis-associated-locomotor-dysfunction
#5
Reza Heidari, Akram Jamshidzadeh, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Hossein Niknahad
Aim of the study: Hepatic encephalopathy and hyperammonemia is a clinical complication associated with liver cirrhosis. The brain is the target organ for ammonia toxicity. Ammonia-induced brain injury is related to oxidative stress, locomotor activity dysfunction, and cognitive deficit, which could lead to permanent brain injury, coma and death if not appropriately managed. There is no promising pharmacological intervention against cirrhosis-associated brain injury. Taurine (TAU) is one of the most abundant amino acids in the human body...
June 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29904722/underrated-enemy-from-nonalcoholic-fatty-liver-disease-to-cancers-of-the-gastrointestinal-tract
#6
REVIEW
Aleksandra Derra, Martyna Bator, Tomasz Menżyk, Michał Kukla
Nonalcoholic fatty liver disease (NAFLD) is intrahepatic ectopic lipid deposition which is present despite a lack of other causes of secondary hepatic fat accumulation. It is the most common chronic liver disorder in the welldeveloped countries. NAFLD is a multidisciplinary disease that affects various systems and organs and is inextricably linked to simple obesity, metabolic syndrome, insulin resistance and overt diabetes mellitus type 2. The positive energy balance related to obesity leads to a variety of systemic changes including modified levels of insulin, insulin- like growth factor-1, adipokines, hepatokines and cytokines...
June 2018: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29904721/surveillance-for-portal-hypertension-in-the-course-of-liver-cirrhosis
#7
REVIEW
Anna Piekarska, Ewa K Berkan, Kamila M Wójcik
Non-invasive liver fibrosis assessment techniques are under development for evaluating the severity of liver disease and portal hypertension. The paper presents practical arrangements for the diagnosis and treatment of portal hypertension in patients with chronic liver disease, established in the Baveno VI Consensus Workshop for diagnosis and treatment of portal hypertension. Currently, the diagnostic standard of liver disease severity is transient elastography, which can identify patients with clinically significant portal hypertension (liver stiffness > 20 kPa)...
June 2018: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29594199/hemospray-for-recurrent-esophageal-band-ulcer-bleeding
#8
Uday A Sanglodkar, Dinesh Jothimani, Mohamed Rela
Rebleeding after initially successful endoscopic variceal ligation (EVL) occurs in 20-60% of patients, most commonly from band ulcers, and is associated with 20-50% mortality. Although band ulcer bleeding has been treated in a number of different ways, no single therapeutic intervention has shown a clear benefit. Hemospray (Cook Medical, Winston-Salem, North Carolina, USA) is a relatively new non-contact hemostatic modality used in the management of bleeding peptic ulcers. It is a nano-powder that can be sprayed over a larger mucosal area...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594198/hepatic-infarction-and-acute-pancreatitis-a-case-report-and-review-of-the-literature
#9
Archana Kulkarni, Hamza Arif, Manik Veer, Kateyln Ziggas, Amit Kaura, Meera Sareen
Hepatic infarction is rare due to the unique dual hepatic blood supply from the hepatic artery and the portal vein. Herein, we report a case of hepatic infarction that occurred as a complication of acute pancreatitis. The patient was a 58-year-old male with past medical history of chronic alcoholism, who presented with epigastric abdominal pain, nausea, and vomiting. Hepatic infarction was diagnosed with computed tomography of the abdomen and pelvis without contrast, which revealed suspicion of splenic vein thrombosis and peripancreatic fat stranding along with a wedge-shaped, peripheral hypo density in the right hepatic lobe with typical morphology for hepatic infarction...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594197/cannulation-in-patients-with-large-periampullary-diverticulum-using-spybite-miniforceps
#10
Mahadevan Balkrishanan, Mayank Jain, Chenduran Snk, Sridhar Cg, Ravi Ramakrishnan, Jayanthi Venkataraman
Introduction: Cannulation is difficult in patients with periampullary diverticulum (PAD). The described success rate varies from 61% to 95.4%. Material and methods: Four cases with PAD in which, despite repeated attempts, we were unable to locate the papilla and cannulate. To overcome this difficulty, we used SpyBite forceps (Boston Scientific) to pull out the papillary orifice and then perform the cannulation using a sphincterotome introduced through the same working channel...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594196/evaluation-of-serum-interleukin-10-levels-in-hepatocellular-carcinoma-patients-a-systematic-review-and-meta-analysis
#11
Ebrahim Shakiba, Mazaher Ramezani, Masoud Sadeghi
Aim of the study: This meta-analysis aimed to evaluate serum IL-10 levels in HCC patients. Material and methods: The three databases PubMed, Scopus and Web of Science were checked on July 2017 for assessment of IL-10 levels in hepatocellular carcinoma (HCC) patients compared with healthy controls in publications with an English abstract. A random-effect meta-analysis was performed using mean difference (MD) and 95% confidence intervals (CIs). Also, publication bias was evaluated through funnel plot analysis with the Begg's and Egger's tests...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594195/effects-of-infection-on-post-transplant-outcomes-living-versus-deceased-donor-liver-transplants
#12
Osama Siddique, Ayesha S Siddique, Jason T Machan, Kittichai Promrat
Introduction: Post-transplant infections have been studied widely but data on comparisons of deceased donor liver transplants (DDLT) and living donor liver transplants (LDLT), type and timings of infections, and their relations to outcomes are not explored. Material and methods: We analysed data from 612 participants of the Adult-to-Adult Living Donor Liver Transplantation Study (A2ALL), a retrospective data set of LDLT and DDLT. We compared the type and timing of the first post-transplant infection in relation to transplant outcomes between the two groups...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594194/the-epidemiology-of-hepatocellular-cancer-in-poland
#13
Dariusz Wasiak, Jacek Pliszczyński, Beata Łągiewska, Maurycy Jonas, Mariusz Panczyk, Piotr Małkowski, Wojciech Lisik, Maciej Kosieradzki
Introduction: This article summarize the available data on hepatocellular carcinoma (HCC) epidemiology in Poland. Data regarding the HCC incidence rate are divergent. Statistical data presented by NFZ appear more credible in that matter than data published by the Polish Oncology Center (POC). Material and methods: The analysis included data from the Polish Bibliography Database (GBL), the Polish National Health Fund Institution (NFZ), the scientific paper "Malignant neoplasms in Poland" issued by POC and the central liver transplant registry maintained by the Polish transplant coordinating center "Poltransplant" (2010-2015)...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594193/expression-of-intrahepatic-cd3-cd4-and-cd8-t-cells-in-biliary-atresia
#14
Behairy E Behairy, Nermine Ehsan, Magdy Anwer, Alif Allam, Ibramem El-Henawy, Nesreen Abdel Hameed, Haidy M Zakaria
Aim of the study: Assessment of the expression of cluster of differentiation (CD)3, CD4, and CD8 T cells in biliary atresia (BA) cases in comparison to neonatal cholestasis other than BA. Material and methods: This study included 79 patients: 34 patients with BA (BA group) and 35 patients with neonatal cholestasis due to causes other than BA (cholestasis group), and 10 normal liver donor as a control group. Immunohistochemical staining or CD3, CD4, and CD8 T cells in liver tissues for the 3 groups were evaluated...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594192/the-influence-of-nafld-on-the-risk-of-atherosclerosis-and-cardiovascular-diseases
#15
REVIEW
Kamila Wójcik-Cichy, Ewa Koślińska-Berkan, Anna Piekarska
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries and is associated with obesity, dyslipidaemia, diabetes, and metabolic syndrome. Atherosclerosis and cardiovascular diseases are also highly prevalent in this group of patients, due to the presence of shared risk factors. The incidences of coronary artery calcification, hypertension, aortic valve sclerosis, diastolic dysfunction, atherosclerotic plaques, and increased carotid intima-media thickness were more common in patients with NAFLD than in those without...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29260002/profile-of-extrahepatic-portal-venous-obstruction-among-children-in-central-india
#16
Mayank Jain, Jenisha Jain, Gauri Rao Passi, Kamna Jain, Shikhar Jain
Introduction: There is a paucity of data regarding the clinical profile of children with extrahepatic portal venous obstruction (EHPVO) from Central India. Material and methods: Retrospective analysis of 30 children with EHPVO treated between 2002 and 2012. Results: The median age of presentation was 12.5 years (range 5-14 years) and median duration of symptoms was 3.2 years (range 0.3-10 years). Home delivery was noted in 30 cases (100%), umbilical sepsis in 8 (27%) and history of cow dung application over the umbilical cord in 2 cases (6...
December 2017: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29260001/normalizing-serum-hepcidin-but-not-%C3%AE-1-antitrypsin-level-during-effective-treatment-of-chronic-hepatitis-c
#17
Magdalena Rogalska-Taranta, Jerzy Jaroszewicz, Robert Flisiak
Aim of the study: We investigated the impact of pegylated interferon α-2 in combination with ribavirin (PEG-IFNα/RBV) treatment on hepcidin and α-1-antitrypsin concentrations in the serum of patients with chronic hepatitis C. Material and methods: We measured serum concentrations of hepcidin, prohepcidin and α-1-antitrypsin by enzyme-linked immunosorbent assays in patients with chronic hepatitis C before and during antiviral therapy. Results: Hepcidin concentrations were increased in both genotype 1b and 3a hepatitis C virus (HCV) infected patients as compared with the control group...
December 2017: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29255810/a-rare-cause-of-gastrointestinal-bleeding-in-the-post-transplant-setting
#18
Piyush Bawane, Mayank Jain, Mahadevan Balkrishnan, R Ravi, Joy Varghese, Jayanthi Venkataraman, Mukul Vij, Mohamed Rela
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication noted after solid organ transplantation and is frequently related to Epstein-Barr virus infection. The present case highlights an unusual presentation of PTLD - gastrointestinal bleeding - in the absence of systemic symptoms.
December 2017: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29255809/autoimmune-hepatitis-and-pregnancy-report-of-two-cases-with-different-maternal-outcomes
#19
Gokcen Orgul, Esra Uyanik Ozkan, H Tolga Celik, M Sinan Beksac
Women of childbearing age with autoimmune hepatitis (AIH) are now able to get pregnant. The progress of the disease during pregnancy is not well clarified yet. The first pregnant woman had cirrhosis secondary to AIH, and she delivered by cesarean section. The patient had severe thrombocytopenia at the time of hospitalization. Unfortunately, she died due to massive thromboembolism at the 24th hour after delivery. The other patient had three recurrent abortions with a diagnosis of AIH. Low-dose low molecular weight heparin and low-dose acetylsalicylic acid along with low-dose prednisolone were administered during the course of the following pregnancies...
December 2017: Clinical and experimental hepatology
https://www.readbyqxmd.com/read/29255808/clinical-usefulness-of-new-noninvasive-serum-biomarkers-for-the-assessment-of-liver-fibrosis-and-steatosis-in-children-with-chronic-hepatitis-c
#20
Maria Pokorska-Śpiewak, Barbara Kowalik-Mikołajewska, Małgorzata Aniszewska, Magdalena Pluta, Magdalena Marczyńska
Aim of the study: Recently, novel serum markers modified by the body mass index z -score (BMI z -score) were proposed as a reliable noninvasive alternative for the detection of significant fibrosis and steatosis in children with chronic hepatitis C (CHC). The aim of this study was to evaluate the clinical usefulness of these biomarkers. Material and methods: Thirty children aged 9.4 ± 3.7 years (14 males, 16 females) with CHC were included in this study. In all patients, histopathological evaluation of the liver fibrosis was performed using a 5-point METAVIR scoring system (≥ 2 points = significant fibrosis)...
December 2017: Clinical and Experimental Hepatology
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