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Chronic Diseases and Translational Medicine

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https://www.readbyqxmd.com/read/29756124/functional-promoter-rs189037-variant-of-atm-is-associated-with-decrease-in-lung-diffusing-capacity-after-irradiation-for-non-small-cell-lung-cancer
#1
Jose Luis Lopez Guerra, Yi-Peng Song, Quynh-Nhu Nguyen, Daniel R Gomez, Zhongxing Liao, Ting Xu
Objective: Single-nucleotide polymorphisms (SNPs) in the ataxia telangiectasia-mutated gene ATM have been linked with pneumonitis after radiotherapy for lung cancer but have not been evaluated in terms of pulmonary function impairment. Here we investigated potential associations between SNPs in ATM and changes in diffusing capacity of the lung for carbon monoxide (DLCO) in patients with non-small-cell lung cancer (NSCLC) after radiotherapy. Methods: From November 1998 through June 2009, 448 consecutive patients with inoperable primary NSCLC underwent definitive (≥60 Gy) radiotherapy, with or without chemotherapy...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756123/the-quality-of-total-mesorectal-excision-specimen-a-review-of-its-macroscopic-assessment-and-prognostic-significance
#2
Shi-Bo Song, Guo-Ju Wu, Hong-Da Pan, Hua Yang, Mao-Lin Hu, Qiang Li, Qiu-Xia Yan, Gang Xiao
As a surgical procedure which could significantly lower the recurrence rate of cancers, total mesorectal excision (TME) has been the gold standard for middle and lower rectal cancer treatment. However, previous studies have shown that the procedure did not achieve the ideal theoretical local recurrence rates of rectal cancers. Some researchers pointed out it was very likely that not all so-called TME treatments completely removed the mesorectum, implying that some of these TME surgical treatments failed to meet oncological quality standards...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756122/very-low-protein-diet-to-postpone-renal-failure-pathophysiology-and-clinical-applications-in-chronic-kidney-disease
#3
Vincenzo Bellizzi, Patrizia Calella, Juan Jesus Carrero, Denis Fouque
The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756121/critically-dysregulated-signaling-pathways-and-clinical-utility-of-the-pathway-biomarkers-in-lymphoid-malignancies
#4
REVIEW
Rui-Fang Sun, Qian-Qian Yu, Ken H Young
Accumulating evidence confirmed that many dysregulated signaling pathways and aberrant genetic alterations contribute to the oncogenesis and heterogeneity of lymphoid malignancies. Therapeutically targeting dysregulating signaling pathways and their hidden oncogenic biomarkers are becoming available, but did not show desired therapeutic effect in current clinical practice. It is meaningful to further understand the underlying mechanisms of the dysregulated signaling pathways and to address the potential utility of pathway-related biomarkers...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756120/quantitative-image-analysis-for-evaluation-of-tumor-response-in-clinical-oncology
#5
Wen-Li Cai, Guo-Bin Hong
The objective, accurate, and standardized evaluation of tumor response to treatment is an indispensable procedure in clinical oncology. Compared to manual measurement, computer-assisted linear measurement can significantly improve the accuracy and reproducibility of tumor burden quantification. For irregular-shaped and infiltrating or diffuse tumors, which are difficult to quantify by linear measurement, computer-assisted volumetric measurement may provide a more objective and sensitive quantification to evaluate tumor response to treatment than linear measurement does...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756119/customization-of-therapy-for-gastroesophageal-adenocarcinoma-patients
#6
Dilsa Mizrak Kaya, Kazuto Harada, Fatemeh G Amlashi, Maria Vasilakopoulou, Jaffer A Ajani
Gastroesophageal adenocarcinomas (GEACs) remain a global health problem. These are most often diagnosed at advanced stage and the estimated 5-year relative survival rate is about 5%. Although cure is not possible for patients with advanced GEAC, systemic therapy (chemotherapy or biochemotherapy) can palliate symptoms, improve survival and provide a better quality of life. One of the most promising options for some patients with advanced stage GEAC is immunotherapy, which can result in durable responses. Numerous phase III trials evaluating targeted therapies in different lines are ongoing and it is hoped that better biomarkers will emerge to identify patients who can benefit from targeted agents and immunotherapy in the future...
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29756118/management-of-gastrointestinal-adverse-events-induced-by-immune-checkpoint-inhibitors
#7
REVIEW
Zheng-Hang Wang, Lin Shen
No abstract text is available yet for this article.
March 2018: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354809/acute-myocardial-infarction-caused-by-myocardial-bridging-alone-confirmed-by-using-intravascular-ultrasonography
#8
Na-Qiong Wu, Mario Evora, U Po Lam, Man Fai Ip, Jian-Jun Li
No abstract text is available yet for this article.
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354808/correlation-between-the-clinicopathological-features-and-prognosis-in-patients-with-extranodal-natural-killer-t-cell-lymphoma
#9
Lin-Shu Zeng, Wen-Ting Huang, Tian Qiu, Ling Shan, Lei Guo, Jian-Ming Ying, Ning Lyu, Xiao-Li Feng
Objective: To investigate the correlation between the clinicopathological features and prognosis in patients with extranodal natural killer (NK)/T-cell lymphoma (ENKTCL). Methods: One hundred and four patients diagnosed with ENKTCL at the Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China from November 1991 to September 2011 were included in the study. The clinicopathological features and their correlations with disease prognosis were evaluated in these patients...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354807/main-air-pollutants-and-ventricular-arrhythmias-in-patients-with-implantable-cardioverter-defibrillators-a-systematic-review-and-meta-analysis
#10
Hong-Jie Yang, Xin Liu, Chuan Qu, Shao-Bo Shi, Jin-Jun Liang, Bo Yang
Objective: Previous studies of ambient air pollutants and ventricular arrhythmias in patients with implantable cardioverter-defibrillator (ICD) have yielded mixed results, and the association between air pollution and ventricular arrhythmias in these patients remains unclear. This study aimed to assess and quantify the association between exposure to major air pollutants [CO, inhalable particles (PM10 ), SO2 , fine particulate matter (PM2.5 ), O3 , and NO2 ] and the presence of ventricular arrhythmia in patients with ICD...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354806/ethnic-differences-in-the-association-between-angiotensin-converting-enzyme-gene-insertion-deletion-polymorphism-and-peripheral-vascular-disease-a-meta-analysis
#11
Chao Han, Xi-Kun Han, Fang-Chao Liu, Jian-Feng Huang
Background: Several studies have investigated the association of angiotensin-converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism with peripheral vascular disease (PVD); however, the results remain controversial. Therefore, we conducted the current meta-analysis to evaluate this relationship in the general population of different ethnicities. Methods: We searched PubMed, Embase, Web of Science, Wanfang Database, and CNKI to identify eligible studies...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354805/current-progress-and-outcomes-of-clinical-trials-on-using-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor-therapy-in-non-small-cell-lung-cancer-patients-with-brain-metastases
#12
Ling-Ling Kong, Lin-Lin Wang, Li-Gang Xing, Jin-Ming Yu
Non-small cell lung cancer (NSCLC) continues to be one of the major causes of cancer-related deaths worldwide, and brain metastases are the major cause of death in NSCLC patients. With recent advances in understanding the underlying molecular mechanism of NSCLC development and progression, mutations in epidermal growth factor receptor ( EGFR ) have been recognized as a key predictor of therapeutic sensitivity to EGFR tyrosine kinase inhibitors (TKIs). Using EGFR-TKI alone or in combination with standard treatments such as whole-brain radiotherapy and surgery has been an effective strategy for the management of brain metastasis...
December 2017: Chronic diseases and translational medicine
https://www.readbyqxmd.com/read/29354804/are-statins-beneficial-for-the-treatment-of-pulmonary-hypertension
#13
REVIEW
Lei Wang, Ting Yang, Chen Wang
Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354803/current-advances-in-circulating-inflammatory-biomarkers-in-atherosclerosis-and-related-cardio-cerebrovascular-diseases
#14
Jun-Xuan Lv, Qi Kong, Xin Ma
Atherosclerosis (AS) is a systemic chronic disease affecting both the coronary and cerebral arteries. Inflammation plays a key role in the initiation and progression of AS, and numerous inflammatory factors have been proposed as potential biomarkers. This article reviews recent research in studies on major circulating inflammatory biomarkers to identify surrogates that may reflect processes associated with AS development and the risk of AS-related vascular events, such as Von Willebrand factor, lectin-like oxidized low-density-lipoprotein receptor-1, soluble urokinase plasminogen activator receptor, regulated upon activation, normal T-cell expressed and secreted, and microparticles, which may provide new perspectives for clinical AS evaluation and risk stratification...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29354802/intracranial-artery-stenosis-current-status-of-evaluation-and-treatment-in-china
#15
Bin Cai, Bin Peng
Intracranial artery stenosis (ICAS), a common cause of ischemic stroke, is a growing cause of concern in China. Recently, many epidemiological, etiological, pathophysiological, therapy, and diagnostic imaging studies have focused on ICAS, and guidelines and consensus on the diagnosis and treatment of ICAS have been published and updated by domestic experts. Such work is pivotal to our enhanced comprehension, diagnosis, and treatment of ICAS. In this review, we summarize the latest progress in the evaluation and treatment of ICAS in China...
December 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29063076/restless-legs-syndrome-secondary-to-pontine-infarction-clinical-analysis-of-five-cases
#16
Hou-Zhen Tuo, Ze-Long Tian, Yi-Nong Cui, Xiao-Yang Ma, Chun-Ling Xu, Hong-Yan Bi, Li-Yan Zhang, Yong-Bo Zhang, Wei-Dong Le, William Ondo
OBJECTIVE: Pontine infarction is a common type of stroke in the cerebral deep structures, resulting from occlusion of small penetrating arteries, may manifest as hemi-paralysis, hemi-sensory deficit, ataxia, vertigo, and bulbar dysfunction, but patients presenting with restless legs syndrome (RLS) are extremely rare. Herein, we reported five cases with RLS as a major manifestation of pontine infarction. METHODS: Five cases of pontine infarction related RLS were collected from July 2013 to February 2016...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29063075/analysis-of-the-parathyroid-function-in-maintenance-hemodialysis-patients-from-changchun-china
#17
Juan Du, Songyan Wang, Wangbo Yu, Shuang Li, Jingbo Xu
OBJECTIVE: To evaluate the parathyroid function in maintenance hemodialysis patients from 4 hemodialysis centers and to analyze the cause of the dysfunction. METHODS: This cross-sectional study included patients with chronic renal disease undergoing maintenance hemodialysis treatment at 4 hemodialysis centers in Changchun, China, between March 2014 and August 2015. A total of 337 patients were asked to complete a questionnaire including their name, gender, age, hemodialysis duration, the use of calcium carbonate and vitamin D3 supplements, health education status, hemofiltration frequency, appetite, and education level...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29063074/evaluation-of-symptoms-and-risks-in-stable-chronic-obstructive-pulmonary-disease-patients-with-radiographic-bronchiectasis
#18
Rong-Bao Zhang, Fei Yuan, Xing-Yu Tan, Quan-Ying He
OBJECTIVE: To investigate the presence of previously undiagnosed radiographic bronchiectasis in stable chronic obstructive pulmonary disease (COPD) patients using high resolution computed tomography (HRCT) and to evaluate the effect of radiographic bronchiectasis on the symptoms and risks in stable COPD patients. METHODS: From May 2012 to April 2014, there were 347 patients enrolled in COPD database. Data describing the general conditions, the frequency of acute exacerbations the year before, COPD assessment test, modified medical research council (mMRC) score, spirometric classification, and HRCT were collected...
September 2017: Chronic diseases and translational medicine
https://www.readbyqxmd.com/read/29063073/the-association-between-metformin-use-and-colorectal-cancer-survival-among-patients-with-diabetes-mellitus-an-updated-meta-analysis
#19
Shan Tian, Hong-Bo Lei, Yu-Lan Liu, Yan Chen, Wei-Guo Dong
OBJECTIVE: Recent studies have reported conflicting results on the correlation between metformin use and outcomes in patients with colorectal cancer (CRC). A meta-analysis was performed to evaluate the efficacy of metformin therapy on the prognosis of CRC patients with type 2 diabetes mellitus (T2DM). METHODS: We conducted a systematic search of PubMed, EMBASE, the Cochrane Library, and the Web of Science for related articles up to August 2016. Two investigators independently identified and extracted information...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29063072/potential-role-of-thymosin-beta-4-in-the-treatment-of-nonalcoholic-fatty-liver-disease
#20
REVIEW
Yong Jiang, Tao Han, Zhi-Guang Zhang, Man Li, Feng-Xiang Qi, Ying Zhang, Ying-Lan Ji
As a result of increased prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has become one of the most common causes of chronic liver disease. Although most NAFLD cases remain benign, some progress to end-stage liver diseases such as cirrhosis and hepatocellular carcinoma. Therefore, treatment should be considered for NAFLD patients who are likely to progress to nonalcoholic steatohepatitis (NASH) or fibrosis. Thymosin beta 4 (Tβ4), a G-actin sequestering peptide, regulates actin polymerization in mammalian cells...
September 2017: Chronic Diseases and Translational Medicine
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