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Integrative Medicine Research

Neha Arora Chugh, Shreya Bali, Ashwani Koul
The use of botanicals for maintaining good health and preventing diseases is undisputed. The claimed health benefits of natural health products and herbal medicines are based on traditional claims, positive results obtained in preclinical studies and early phase clinical trials that are not backed by safety and efficacy evidences approved by regulatory agencies. Although, the popularity of botanicals is growing, health care practitioners of modern medicine seldom recommend their use because of ill equipped database of their safety and potency...
June 2018: Integrative Medicine Research
Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa
Background: Yokukansan (YKS), a traditional herbal (Kampo) medicine consisting of seven herbs, is effective in the treatment of pain disorders, such as headache, postherpetic neuralgia, fibromyalgia, and trigeminal neuralgia, and we have previously shown it to be effective against morphine analgesic tolerance in rats. It has been reported that orexin receptor antagonists prevent the development of morphine tolerance and that YKS inhibits the secretion of orexin A in the hypothalamus. This study examined whether the inhibition of the secretion of orexin A by YKS is one mechanism underlying its effect against morphine analgesic tolerance...
June 2018: Integrative Medicine Research
Chang-Gue Son
Nonalcoholic fatty liver disease (NAFLD) has become the common cause leading to chronic liver diseases recently. Unlikely past humankind history, NAFLD is like a new illness especially in developed countries due to decreased number of hepatic virus carriers and increased population with obesity. Among subjects with NAFLD, development of nonalcoholic steatohepatitis (NASH) is a key pathological step which determines the clinical progression. This study reports a case of a boy who has suffered from NASH for 2 years...
June 2018: Integrative Medicine Research
Funmilayo I D Afolayan, Blessing Erinwusi, Oyetunde T Oyeyemi
Background: Studies have shown that curcumin from Curcuma longa has a wide range of medicinal and immunomodulatory properties. These activities have, however, been hindered by its low bioavailability. Meanwhile, incorporation of nanoparticles has been shown to increase bioavailability of certain drugs. This study was, therefore, conducted to comparatively evaluate the immunomodulatory activity of free and nanoparticulate curcumin in mice. Methods: Healthy albino mice were sensitized with sheep red blood cells (SRBCs) and thereafter free and nanoparticulate curcumin were administered orally at doses of 5 mg/kg/day and 10 mg/kg/day for 10 days to the mice...
June 2018: Integrative Medicine Research
Tobias Romeyke, Elisabeth Noehammer, Harald Stummer
Patients with fibromyalgia (FM) have often tried many outpatient treatments, and breakthrough pain frequently stops them from performing everyday tasks and participating in society. FM-pain that has become chronic, therefore, affects quality of life. This case study describes the administration of interdisciplinary inpatient pain therapy due to a primary diagnosis of fibromyalgia with integrated complementary medicine. The female patient, who had several concomitant disorders and had been suffering from pain for many years, benefited from the holistic treatment approach in terms of a reduction in pain and an improvement in physical functions and mental health...
June 2018: Integrative Medicine Research
Chen Chen, Bai Lin Cong, Min Wang, Muhammad Abdullah, Xiao Long Wang, Yin Hua Zhang, Shun Ji Xu, Lan Cui
Background: Neutrophil to lymphocyte ratio (NLR) in peripheral blood is established to correlate with the morbidity and mortality of heart disease patients. We aimed to define the severity of inflammation (NLR) by observing the association of NLR with cardiac functions or myocardial damage parameters in patients with acute myocardial infarction. Methods: Data from 715 patients who underwent percutaneous coronary intervention (PCI) within 72 hours of incidence in 2016 were analysed retrospectively...
June 2018: Integrative Medicine Research
Muhammad Maqsood, Rahmatullah Qureshi, Masroor Ikram, M Sheeraz Ahmad, Bushra Jabeen, Muhammad Rafique Asi, Junaid Ahmed Khan, Safdar Ali, Lothar Lilge
Background: The Pakistani Salt Range has a rich floral diversity including Withania coagulans from the Solanaceae family. Methods: The crude methanolic extracts of the root, leaf, leaf stalk, and fruit of this plant were screened for their cytotoxic activity against human (HeLa, MCF-7, RD) and rat (RG2 and INS-1) cancer cell lines at 20 μg/mL and compared to methotrexate. The IC50 values indicated that leaf stalk and fruit extracts exert an 80% or higher cytotoxic activity against all cell lines at 24 hours...
June 2018: Integrative Medicine Research
Mohammad Faheem Khan, Arun Kumar Rawat, Shahnaaz Khatoon, Mohd Kamil Hussain, Arvind Mishra, Devendra Singh Negi
Background: To investigate the antidiabetic effect of Himalayan Medicinal plants from India viz . Melia azedarach (Family: Meliaceae), Zanthoxylum alatum (Family: Rutaceae), Tanacetum nubigenum (Family: Asteraceae) using in-vitro as well as in-vivo approaches. Methods: Their effects were examined on stimulation of glucose uptake by C2C12 cultured cell line, inhibitory effect on human recombinant Protein tyrosine phosphatase-1B (PTP-1B) and followed by the hypoglycaemic activity of extracts in Streptozotocin (STZ) induced diabetic rats...
June 2018: Integrative Medicine Research
Jagan Nadipelly, Vijaykumar Sayeli, Parimala Kadhirvelu, Jaikumar Shanmugasundaram, Binoy Varghese Cheriyan, Viswanathan Subramanian
Background: The anti - nociceptive effect of 7, 2', 3' - trimethoxy flavone, 7, 2', 4' - trimethoxy flavone, 7, 3', 4' - trimethoxy flavone and 7, 5, 4' - trimethoxy flavone against inflammatory, neurogenic and thermal pain in mice was reported earlier. The present study was designed to investigate the effect of the above trimethoxy flavones in amelioration of peripheral neuropathy induced by paclitaxel. Methods: Peripheral neuropathy was induced in mice by administration of a single i...
June 2018: Integrative Medicine Research
Rabiat Unekwu Hamzah, Alli Abdullahi Jigam, Hussaini Anthony Makun, Evans Chidi Egwim, Hadiza Lami Muhammad, Musa Bola Busari, Gabriel Femi Ibikunle, Sulaiman Kolapo Abubakar-Akanbi
Background: This study was designed to determine the hepatoprotective effect of partially purified fractions from Pterocarpus mildbraedii extract on carbon tetrachloride (CCl4 ) intoxicated rats. Methods: The methanol extract of P. mildbraedii was subjected to solvent partitioning using n-hexane, chloroform, ethylacetate and water. Separation of fractions with proven antioxidant activity was achieved by chromatographic techniques. Acute toxicity and hepatoprotective studies of the methanol sub-fraction 6 (Me 6), methanol sub-fraction 7 (Me 7) and methanol sub-fraction 8 (Me 8) from P...
June 2018: Integrative Medicine Research
Jeongyun Lee, Mi Hong Yim, Jong Yeol Kim
Background: The Sasang constitutional analysis tool (SCAT) is an integrated Sasang constitutional analysis system developed by the Korea Institute of Oriental Medicine. This study aimed to evaluate the reliability of a questionnaire for measuring personality and pathophysiological symptoms that is one of the components of the SCAT. Methods: In this study, data were collected from university students in their twenties. Tests were administered twice, with an interval of 4 weeks between tests...
June 2018: Integrative Medicine Research
Mohammad Setayesh, Arman Zargaran, Amir Reza Sadeghifar, Mehdi Salehi, Hossein Rezaeizadeh
Carpal tunnel syndrome (CTS) is defined as a compressing median mononeuropathy. CTS is one of the major costly debilitating diseases of the hand. Although CTS is a relatively recent concept in current medicine, some evidences show that medieval physicians in Persian medicine (PM) such as Avicenna were familiar with it. The PM textbook written by Avicenna, the Canon of Medicine, defines the anatomy of carpal tunnel and median nerve, as well as mononeuropathy; it also offers suggestions for the prevention and treatment of carpal tunnel syndrome (called as Vaja al-asab and Khadar ) in the chapter of nerve diseases...
June 2018: Integrative Medicine Research
Kyung Eun Lee, Joong Jae Kim, Hee-Jeong Jin, Siwoo Lee, Eun Bo Shim
[This corrects the article DOI: 10.1016/j.imr.2017.01.005.].
March 2018: Integrative Medicine Research
Keisou Ishimaru, Takuma Nakajima, Yoshihisa Namiki, Kenji Ryotokuji
Background: We previously reported that pinpoint plantar long-wavelength infrared light irradiation (stress-free therapy; SFT) is useful for alleviating insulin resistance and improving intracranial blood flow in patients with type 2 diabetes mellitus. This study was undertaken to evaluate the influences of SFT on chorioretinal hemodynamics (retinal artery and vein blood flows) as well as atherosclerosis-related factors (TG, LDL-C) and VEGF in patients with dyslipidemia. Methods: Four patients with dyslipidemia received 15-minute irradiation with a stress-free apparatus (far-infrared wavelength, 30 mW)...
March 2018: Integrative Medicine Research
Bok-Nam Seo, Ji-Eun Park, Young-Eun Kim, Kyung-Won Kang, In-Chan Seol, Sun-Mi Choi
Background: Hypertension is a major cause of cardiovascular disease and associated mortality, and postmenopausal women are at a high risk of hypertension. We aim to investigate the hypotensive effect and safety of acupuncture, focusing on postmenopausal women with prehypertension and stage 1 hypertension. In addition, we aim to investigate whether the effect of acupuncture treatment differed, depending on Sasang Constitution and cold-heat pattern. Methods: This study is designed as an intervention cohort study...
March 2018: Integrative Medicine Research
Harith Jameel Mahdi, Nurzalina Abdul Karim Khan, Mohd Zaini Bin Asmawi, Roziahanim Mahmud, Vikneswaran A/L Murugaiyah
Background: The medicinal uses of plants are in many cases based exclusively on traditional knowledge without enough scientific evidences. Different parts of Moringa oleifera were traditionally used for the treatment of wide variety of ailments including arthritis and joints pain. The present study had been designed to evaluate the anti-arthritic and anti-nociceptive activities of ethanol extract of Moringa leaves, this being the most abundant plant part suitable for commercial mass production of botanical medicinal products...
March 2018: Integrative Medicine Research
Bo Kyung Hwang, Yeo-Jin Yoon, Sang Yun Han, Soo Jin Lee, Han Chae
Background: The Yin-Yang is a pivotal concept of traditional East-Asian medicine, however the stability of Yin-Yang temperament in Sasang Personality Questionnaire (SPQ) over time has not been extensively studied. The purpose of this study was to examine the test-retest validity of SPQ with a large number of participants. Methods: SPQ test was conducted two times with three months interval in 247 Korean university students. The structural validity of first SPQ data was examined with Factor analysis and Cronbach's alpha, and the correlation between first and second measure of SPQ was attested with Pearson's correlation...
March 2018: Integrative Medicine Research
Jeongyun Lee, Sang Yun Han, Minwoo Hwang, Nayoung Bae, Han Chae
Background: The Sasang typology is a traditional Korean personalized medicine and its Cold-Heat subgroup identification is essential for effective use of medical herbs and acupuncture. The purpose of this study was to discover differences between Cold-Heat subgroups with objective clinical measures and to examine its clinical usefulness. Methods: The pathophysiological symptoms of the digestive system, temperament and body shape of 241 patients were measured using the Sasang Digestive Function Inventory (SDFI), Sasang Personality Questionnaire (SPQ) and Body Mass Index (BMI)...
March 2018: Integrative Medicine Research
Kwang-Ho Bae, Young-Seok Jeong, Ho-Yeon Go, Seung-Ho Sun, Tae-Hoon Kim, Ki-Yong Jung, Yun-Kyung Song, Seong-Gyu Ko, You-Kyung Choi, Jong-Hyeong Park, Siwoo Lee, Youngseop Lee, Chan-Yong Jeon
Background: Cold hypersensitivity in the hands and feet (CHHF) is a symptom patients usually feel cold in their hands and feet, but not dealt with a disease in western medicine. However, it is often appealed by patients at a clinic of Korean medicine (KM), considered to be a sort of key diagnostic indicator, and actively treated by physicians. Nevertheless, there is no standardized diagnostic definition for CHHF. Therefore, we surveyed KM experts' opinions to address the clinical definition, diagnostic criteria, and other relevant things on CHHF...
March 2018: Integrative Medicine Research
Enosakhare A Asemota, Ifeyinwa M Okafor, Henshaw U Okoroiwu, Ewaro R Ekong, Stanley Obialor Anyanwu, Esienanwan Esien Efiong, Francis Udomah
Background: Low concentration of trace elements has been associated with poor prognosis and mortality in HIV infection. Methods: A cross sectional study was conducted among 100 HIV-infected subjects (70 were on ART treatment, while 30 were ART naïve). Fifty (50) apparently healthy controls were enrolled. Concentration of serum levels of zinc and copper was done using atomic absorption spectrometric method, while complete blood count was determined using automated blood analyzer...
March 2018: Integrative Medicine Research
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