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Ophthalmology Retina

Ryan Swan, Sang Jin Kim, J Peter Campbell, R V Paul Chan, Kemal Sonmez, Kent D Taylor, Xiaohui Li, Yii-Der Ida Chen, Jerome I Rotter, Charles Simmons, Michael F Chiang
TOPIC: Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease in premature infants, and is a major cause of childhood blindness worldwide. In addition to known clinical risk factors such as low birth weight and gestational age, there is a growing body of evidence supporting a genetic basis for ROP. CLINICAL RELEVANCE: While comorbidities and environmental factors have been identified as contributing to ROP outcomes in premature infants, most notably gestational age and oxygen, some infants progress to severe disease despite absence of these clinical risk factors...
September 2018: Ophthalmology retina
Scott M McClintic, Simon Gao, Jie Wang, Ahmed Hagag, Andreas K Lauer, Christina J Flaxel, Kavita Bhavsar, Thomas S Hwang, David Huang, Yali Jia, Steven T Bailey
Purpose: To use optical coherence tomography angiography (OCTA) derived quantitative metrics to assess the response of choroidal neovascularization to pro-re-nata (PRN) anti-endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (AMD). Design: Prospective longitudinal cohort study. Participants: Fourteen eyes from 14 study participants with treatment-naïve neovascular AMD were enrolled. Methods: Subjects were evaluated monthly and treated with intravitreal anti-VEGF agents under a PRN protocol for one year...
September 2018: Ophthalmology Retina
Touka Banaee, Rishi P Singh, Kathryn Champ, Felipe F Conti, Karen Wai, Jim Bena, Lucas Beven, Justis P Ehlers
Purpose: To evaluate the association of baseline ellipsoid zone (EZ) parameters on optical coherence tomography (OCT) as calculated by a semi-automated computer algorithm with baseline visual acuity in eyes with retinal vein occlusion (RVO). Design: Retrospective consecutive case series. Subjects: Patients affected by RVO presenting from January 2011 to December 2014. Methods: Baseline demographics, clinical characteristics, and SD-OCT data at presentation were collected...
August 2018: Ophthalmology Retina
S Grace Prakalapakorn, Sharon F Freedman, Amy K Hutchinson, David K Wallace, Sandra S Stinnett, J Wayne Riggins, Keith J Gallaher
PURPOSE: To evaluate (1) the feasibility of non-ophthalmologist healthcare workers (HCWs) to obtain images of sufficient quality for retinopathy of prematurity (ROP) screening using a FDA-approved portable, non-contact, narrow-field fundus camera (i.e., Pictor™), and (2) the accuracy of grading these images to identify infants who developed treatment-warranted (type 1) ROP. DESIGN: Prospective cohort study. SUBJECTS: Infants undergoing routine ROP screening examinations (i...
August 2018: Ophthalmology retina
Rachel C Patel, Jie Wang, Thomas S Hwang, Miao Zhang, Simon S Gao, Mark E Pennesi, Steven T Bailey, Brandon J Lujan, Xiaogang Wang, David J Wilson, David Huang, Yali Jia
Objective: To evaluate the projection-resolved (PR) optical coherence tomography angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologies. Design: Cross-sectional observational clinical study. Participants: Patients diagnosed with retinal vascular diseases and healthy volunteers. Methods: Eyes were imaged using an OCT system operating at 840 nm and employing the split-spectrum amplitude decorrelation algorithm...
August 2018: Ophthalmology Retina
Stacy M Scofield-Kaplan, Royce W S Chen, Harry W Flynn, James Lin, Jason D Horowitz
No abstract text is available yet for this article.
July 2018: Ophthalmology Retina
Amir H Kashani, Kyle M Green, Julie Kwon, Zhongdi Chu, Qinqin Zhang, Ruikang K Wang, Sean Garrity, David Sarraf, Carl B Rebhun, Nadia K Waheed, Karen B Schaal, Marion R Munk, Sarra Gattoussi, K Bailey Freund, Fang Zheng, Guanghui Liu, Philip J Rosenfeld
Objective: To characterize features of extra-vascular optical coherence tomography angiography (OCTA) signals corresponding to hyperreflective intraretinal fluid across various exudative maculopathies. Design: Multicenter, retrospective, observational study. Participants: Eyes with various forms of exudative maculopathy including diabetic retinopathy (DR), retinal vein occlusion (RVO), and neovascular-age related macular degeneration (nvAMD)...
July 2018: Ophthalmology Retina
Kaivon Pakzad-Vaezi, Kosar Khaksari, Zhongdi Chu, Russell N Van Gelder, Ruikang K Wang, Kathryn L Pepple
Purpose: To examine and quantify choriocapillaris lesions in active and quiescent serpiginous choroiditis (SC) using swept-source optical coherence tomography angiography (SS-OCTA) and en-face image analysis. Design: Prospective observational case series. Participants: Patients with a clinical diagnosis of SC. Methods: A SS-OCTA prototype was used to image active and quiescent serpiginous lesions longitudinally before and after anti-inflammatory treatment...
July 2018: Ophthalmology Retina
Jennifer Enright, Richard Schroeder, James R Waymack, Gregg Lueder, Rithwick Rajagopal
No abstract text is available yet for this article.
June 2018: Ophthalmology Retina
Lydia Sauer, Rebekah H Gensure, Martin Hammer, Paul S Bernstein
Purpose: Macular Telangiectasia Type 2 (MacTel) is an uncommon, late-onset complex retinal disease that leads to central vision loss. No causative gene(s) have been identified so far, resulting in a challenging clinical diagnostic dilemma because retinal changes of early stages are often subtle. The objective of this study was to investigate the benefit of fluorescence lifetime imaging ophthalmoscopy (FLIO) for retinal imaging in patients with MacTel. Design: Cross-sectional study from a tertiary-care retinal referral practice...
June 2018: Ophthalmology Retina
Amy S Babiuch, Mehnaz Khan, Ming Hu, Peter K Kaiser, Sunil K Srivastava, Rishi P Singh, Allison Watts, Jamie L Reese, Justis P Ehlers
Purpose: To compare review strategies for optical coherence tomography angiography (OCT-A) for multiple disease features found in common diseases of the choroid and retina. Design: Prospective, observational study. Participants: Patients with macular disease undergoing routine spectral-domain optical coherence tomography (SDOCT). Methods: Eyes were imaged with the Avanti RTVue XR HD (Optovue, Fremont, CA), and the split-spectrum amplitude decorrelation angiography (SSADA) algorithm software was utilized for OCT-A performance...
June 2018: Ophthalmology Retina
Gui-Shuang Ying, Maureen G Maguire, Wei Pan, Juan E Grunwald, Ebenezer Daniel, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Daniel F Martin
Purpose: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). Design: Secondary analysis of data from a cohort study. Participants: Patients enrolled in the Comparison of AMD Treatments Trials (CATT) who completed a 5-year follow-up visit. Methods: Participants were randomly assigned to ranibizumab or bevacizumab and to 1 of 3 dosing regimens...
June 2018: Ophthalmology Retina
Mehnaz Khan, Sunil K Srivastava, Jamie L Reese, Zryan Shwani, Justis P Ehlers
Purpose: To delineate the feasibility and role of intraoperative optical coherence tomography (iOCT) in surgical decision-making during vitreoretinal surgical interventions for proliferative diabetic retinopathy (PDR). Design: Prospective, single-site, multi-surgeon consecutive case series. Participants: Patients enrolled in the DISCOVER study who underwent vitreoretinal surgery for sequelae of PDR. Methods: Subjects were identified from the first 2 years of the DISCOVER study that underwent vitreoretinal surgery for complications of PDR...
May 2018: Ophthalmology Retina
William G Christen, Daniel I Chasman, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, Julie E Buring
No abstract text is available yet for this article.
May 2018: Ophthalmology Retina
Gary Gensler, Traci E Clemons, Amitha Domalpally, Ronald P Danis, Barbara Blodi, Jack Wells, Michael Rauser, John Hoskins, G Baker Hubbard, Michael J Elman, Gary E Fish, Alexander Brucker, Alan Margherio, Emily Y Chew
Objective/Purpose: To evaluate efficacy and safety of monthly intravitreal injections of sirolimus, an immunosuppressive drug, for the treatment of age-related macular degeneration associated geographic atrophy (GA). Design: Randomized, controlled, single-masked multi-center phase 2 clinical trial of intravitreal sirolimus vs. sham therapy in AREDS2 clinical centers. Subjects: Participants with GA. Methods: Participants eligible in one eye were randomly assigned to a monthly intravitreal injection of sirolimus (20 µL [440 µg]) or sham treatment while participants with two study eyes were assigned to a monthly intravitreal injection in a randomly-selected eye...
May 2018: Ophthalmology Retina
Ahmed M Hagag, Alex D Pechauer, Liang Liu, Jie Wang, Miao Zhang, Yali Jia, David Huang
Purpose: Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design: Prospective cohort study. Participants: Nine eyes from 9 healthy participants. Methods: One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm2 ) were acquired at baseline and during oxygen breathing...
April 2018: Ophthalmology Retina
Morton F Goldberg, Scott McLeod, Mark Tso, Kirk Packo, Malia Edwards, Imran A Bhutto, Rajkumar Baldeosingh, Charles Eberhart, Bernhard H F Weber, Gerard A Lutty
Purpose: To assess the immunohistochemical and histopathological changes in a subject with Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC). Design: Case study. Participant: Ninety two year-old Caucasian male with ADVIRC. Methods: The subject was documented clinically for 54 Years. The retina/choroid complex of the right eye was evaluated with cryosections stained with hematoxylin and eosin or periodic acid schiff reagent...
April 2018: Ophthalmology Retina
Justis P Ehlers, Mehnaz Khan, Daniel Petkovsek, Laura Stiegel, Peter K Kaiser, Rishi P Singh, Jamie L Reese, Sunil K Srivastava
Purpose: To assess the retinal architecture changes which occur during epiretinal membrane (ERM) surgery, utilizing intraoperative optical coherence tomography ( i OCT). Design: Prospective multi-surgeon single center study. Subjects/Participants: Subjects from the PIONEER i OCT study who underwent surgical intervention for management of ERM. Methods: All subjects underwent vitrectomy with ERM peeling with optional internal limiting membrane (ILM) peeling...
April 2018: Ophthalmology Retina
Alison H Skalet, Liang Liu, Christina Binder, Audra K Miller, Jie Wang, David J Wilson, Richard Crilly, Charles R Thomas, Arthur Y Hung, David Huang, Yali Jia
Objective: To study peripapillary retinal capillary circulation in eyes treated with I-125 plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design: Cross-sectional study of 10 subjects imaged with OCTA prior to uveal melanoma treatment and 15 subjects imaged after development of radiation retinopathy and/or optic neuropathy. Participants: Following IRB approval, subjects were enrolled from an academic ocular oncology clinical practice...
March 2018: Ophthalmology retina
Justis P Ehlers, Kevin Wang, Rishi P Singh, Amy S Babiuch, Andrew P Schachat, Alex Yuan, Jamie L Reese, Laura Stiegel, Sunil K Srivastava
Purpose: To assess the efficacy of ranibizumab for persistent diabetic macular edema (DME) previously treated with bevacizumab and compare monthly vs treat-and-extend (TAE) dosing. Design: 12-month, open-label, prospective randomized comparative dosing study. Participants: 27 participants with persistent foveal-involving DME recently treated with bevacizumab. Methods: All subjects were to receive three initial monthly 0...
March 2018: Ophthalmology Retina
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