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Ophthalmology Retina

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https://www.readbyqxmd.com/read/29938247/baseline-predictors-for-five-year-visual-acuity-outcomes-in-the-comparison-of-amd-treatment-trials
#1
Gui-Shuang Ying, Maureen G Maguire, Wei Pan, Juan E Grunwald, Ebenezer Daniel, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Daniel F Martin
Purpose: To determine baseline predictors of visual acuity (VA) outcomes at 5 years after initiating treatment with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD). Design: Secondary analysis of data from a cohort study. Participants: Patients enrolled in the Comparison of AMD Treatments Trials (CATT) who completed a 5-year follow-up visit. Methods: Participants were randomly assigned to ranibizumab or bevacizumab and to 1 of 3 dosing regimens...
June 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29963648/homocysteine-b-vitamins-mthfr-genotype-and-incident-age-related-macular-degeneration
#2
William G Christen, Daniel I Chasman, Nancy R Cook, Stephanie E Chiuve, Paul M Ridker, Julie E Buring
No abstract text is available yet for this article.
May 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29806044/treatment-of-geographic-atrophy-with-intravitreal-sirolimus-the-age-related-eye-disease-study-2-ancillary-study
#3
Gary Gensler, Traci E Clemons, Amitha Domalpally, Ronald P Danis, Barbara Blodi, Jack Wells, Michael Rauser, John Hoskins, G Baker Hubbard, Michael J Elman, Gary E Fish, Alexander Brucker, Alan Margherio, Emily Y Chew
Objective/Purpose: To evaluate efficacy and safety of monthly intravitreal injections of sirolimus, an immunosuppressive drug, for the treatment of age-related macular degeneration associated geographic atrophy (GA). Design: Randomized, controlled, single-masked multi-center phase 2 clinical trial of intravitreal sirolimus vs. sham therapy in AREDS2 clinical centers. Subjects: Participants with GA. Methods: Participants eligible in one eye were randomly assigned to a monthly intravitreal injection of sirolimus (20 µL [440 µg]) or sham treatment while participants with two study eyes were assigned to a monthly intravitreal injection in a randomly-selected eye...
May 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29888339/oct-angiography-changes-in-the-3-parafoveal-retinal-plexuses-in-response-to-hyperoxia
#4
Ahmed M Hagag, Alex D Pechauer, Liang Liu, Jie Wang, Miao Zhang, Yali Jia, David Huang
Purpose: Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design: Prospective cohort study. Participants: Nine eyes from 9 healthy participants. Methods: One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 × 3 mm2 ) were acquired at baseline and during oxygen breathing...
April 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29774302/ocular-histopathology-and-immunohistochemical-analysis-in-the-oldest-known-individual-with-autosomal-dominant-vitreoretinochoroidopathy
#5
Morton F Goldberg, Scott McLeod, Mark Tso, Kirk Packo, Malia Edwards, Imran A Bhutto, Rajkumar Baldeosingh, Charles Eberhart, Bernhard H F Weber, Gerard A Lutty
Purpose: To assess the immunohistochemical and histopathological changes in a subject with Autosomal Dominant Vitreoretinochoroidopathy (ADVIRC). Design: Case study. Participant: Ninety two year-old Caucasian male with ADVIRC. Methods: The subject was documented clinically for 54 Years. The retina/choroid complex of the right eye was evaluated with cryosections stained with hematoxylin and eosin or periodic acid schiff reagent...
April 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29651467/outcomes-of-intraoperative-oct-assisted-epiretinal-membrane-surgery-from-the-pioneer-study
#6
Justis P Ehlers, Mehnaz Khan, Daniel Petkovsek, Laura Stiegel, Peter K Kaiser, Rishi P Singh, Jamie L Reese, Sunil K Srivastava
Purpose: To assess the retinal architecture changes which occur during epiretinal membrane (ERM) surgery, utilizing intraoperative optical coherence tomography ( i OCT). Design: Prospective multi-surgeon single center study. Subjects/Participants: Subjects from the PIONEER i OCT study who underwent surgical intervention for management of ERM. Methods: All subjects underwent vitrectomy with ERM peeling with optional internal limiting membrane (ILM) peeling...
April 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29732441/quantitative-oct-angiography-evaluation-of-peripapillary-retinal-circulation-after-plaque-brachytherapy
#7
Alison H Skalet, Liang Liu, Christina Binder, Audra K Miller, Jie Wang, David J Wilson, Richard Crilly, Charles R Thomas, Arthur Y Hung, David Huang, Yali Jia
Objective: To study peripapillary retinal capillary circulation in eyes treated with I-125 plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design: Cross-sectional study of 10 subjects imaged with OCTA prior to uveal melanoma treatment and 15 subjects imaged after development of radiation retinopathy and/or optic neuropathy. Participants: Following IRB approval, subjects were enrolled from an academic ocular oncology clinical practice...
March 2018: Ophthalmology retina
https://www.readbyqxmd.com/read/29527585/a-prospective-randomized-comparative-dosing-trial-of-ranibizumab-in-bevacizumab-resistant-diabetic-macular-edema-the-react-study
#8
Justis P Ehlers, Kevin Wang, Rishi P Singh, Amy S Babiuch, Andrew P Schachat, Alex Yuan, Jamie L Reese, Laura Stiegel, Sunil K Srivastava
Purpose: To assess the efficacy of ranibizumab for persistent diabetic macular edema (DME) previously treated with bevacizumab and compare monthly vs treat-and-extend (TAE) dosing. Design: 12-month, open-label, prospective randomized comparative dosing study. Participants: 27 participants with persistent foveal-involving DME recently treated with bevacizumab. Methods: All subjects were to receive three initial monthly 0...
March 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29756079/structural-and-electrophysiologic-outcomes-in-a-patient-with-retinal-metallosis
#9
Michael E Sulewski, Leona W Serrano, Grace Han, Tomas S Aleman, Charles W Nichols
No abstract text is available yet for this article.
February 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29503969/factors-associated-with-prevalent-diabetic-retinopathy-in-chinese-americans-the-chinese-american-eye-study
#10
Douglas A Stram, Xuejuan Jiang, Rohit Varma, Mina Torres, Bruce S Burkemper, Farzana Choudhury, Ronald Klein, W James Gauderman, Roberta McKean-Cowdin
Objective: To identify factors associated with prevalent diabetic retinopathy (DR) among Chinese American adults with type 2 diabetes mellitus (T2DM), and to compare these factors to ones previously described for a population-based sample of Latinos with a higher DR prevalence. Design: Population-based cross-sectional study. Participants: 4582 Chinese Americans aged 50 or older residing in Monterey Park, California. Methods: Participants completed an in-home questionnaire on socio-demographic status and medical history, and a comprehensive clinical eye examination, using the same protocol implemented in the Los Angeles Latino Eye Study...
February 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29423458/posterior-ciliary-artery-occlusion
#11
Sohan Singh Hayreh
Objective: To compare the severity of ischemic damage following posterior ciliary artery (PCA) occlusion in old, atherosclerotic, hypertensive monkeys to that in young monkeys. Design: Experimental study. Subjects: Seven eyes of normal, healthy rhesus monkeys and 8 of old, atherosclerotic, hypertensive monkeys. Methods: By lateral orbitotomy, all PCAs were cut behind the eyeball in both groups of animals. The fundus and the optic disc were evaluated by repeated ophthalmoscopy, color fundus photography and fluorescein fundus angiography, before and immediately after cutting the PCAs and serially thereafter during the follow-up period...
February 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29376143/bevacizumab-injection-in-patients-with-neovascular-age-related-macular-degeneration-increases-angiogenic-biomarkers
#12
Thiago Cabral, Luiz H Lima, Luiz Guilherme M Mello, Júlia Polido, Éverton P Correa, Akiyoshi Oshima, Jimmy Duong, Pedro Serracarbassa, Caio V Regatieri, Vinit B Mahajan, Rubens Belfort
Purpose: To evaluate the expression of 19 angiogenic biomarkers in the aqueous humor before and after intravitreal bevacizumab injection (IVB) in eyes with neovascular age-related macular degeneration (AMD). Design: Prospective, noncomparative, interventional case series. Participants: Twenty-three eyes of 23 treatment-naïve patients with choroidal neovascularization (CNV) secondary to neovascular AMD. Methods: Eyes were diagnosed with CNV secondary to neovascular AMD and were treated with 3 monthly IVBs...
January 2018: Ophthalmology Retina
https://www.readbyqxmd.com/read/29372189/the-oct-angiography-revolution-five-emerging-themes
#13
Justis P Ehlers
No abstract text is available yet for this article.
November 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/29372188/intraoperative-oct-of-a-retinal-tack
#14
Aleksandra V Rachitskaya, Justis P Ehlers, Alex Yuan
No abstract text is available yet for this article.
September 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/29038796/serious-adverse-events-with-bevacizumab-or-ranibizumab-for-age-related-macular-degeneration-meta-analysis-of-individual-patient-data
#15
(no author information available yet)
TOPIC: A comparison between ranibizumab and bevacizumab of the incidence of systemic serious adverse events (SAEs) among patients with neovascular age-related macular degeneration (nAMD) who participated in a large-scale randomized trial. Use of individual patient data, rather than aggregate data, allowed adjustment for strong predictors of SAEs. CLINICAL RELEVANCE: Relative safety of ranibizumab and bevacizumab is important in choosing an anti-VEGF drug for the hundreds of thousands of patients with nAMD treated each year worldwide...
September 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/29034359/the-definition-rationale-and-effects-of-thresholding-in-oct-angiography
#16
Emily D Cole, Eric M Moult, Sabin Dang, WooJhon Choi, Stefan B Ploner, ByungKun Lee, Ricardo Louzada, Eduardo Novais, Julia Schottenhamml, Lennart Husvogt, Andreas Maier, James G Fujimoto, Nadia K Waheed, Jay S Duker
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA)...
September 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/29057386/sensitivity-and-specificity-of-oct-angiography-to-detect-choroidal-neovascularization
#17
Ambar Faridi, Yali Jia, Simon S Gao, David Huang, Kavita V Bhavsar, David J Wilson, Andrew Sill, Christina J Flaxel, Thomas S Hwang, Andreas K Lauer, Steven T Bailey
PURPOSE: To determine the sensitivity and specificity of optical coherence tomography angiography (OCTA) in the detection of choroidal neovascularization (CNV) in age-related macular degeneration (AMD). DESIGN: Prospective case series. SUBJECTS: Prospective series of seventy-two eyes were studied, which included eyes with treatment-naive CNV due to AMD, non-neovascular AMD, and normal controls. METHODS: All eyes underwent OCTA with a spectral domain (SD) OCT (Optovue, Inc...
July 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/28944318/intereye-agreement-of-retinopathy-of-prematurity-from-image-evaluation-in-the-telemedicine-approaches-to-evaluating-of-acute-phase-rop-e-rop-study
#18
Gui-Shuang Ying, Wei Pan, Graham E Quinn, Ebenezer Daniel, Michael X Repka, Agnieshka Baumritter
PURPOSE: To determine the symmetry on retinal image grading of fellow eyes for retinopathy of prematurity (ROP) features (stage, zone and plus disease) and severity, to provide the basis for the within subject comparison for ROP trials. DESIGN: Secondary analyses of data from the Telemedicine Approaches to Evaluating of Acute-Phase ROP (e-ROP) Study. SUBJECTS: Infants with birth weight less than 1251g. METHODS: Infants underwent serial retinal imaging sessions in both eyes by certified imagers starting at 32-weeks postmenstrual age (PMA)...
July 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/28971164/endophthalmitis-caused-by-corynebacterium-species-clinical-features-antibiotic-susceptibility-and-treatment-outcomes
#19
Ajay E Kuriyan, Jayanth Sridhar, Harry W Flynn, Laura C Huang, Nicolas A Yannuzzi, William E Smiddy, Janet L Davis, Thomas A Albini, Audina M Berrocal, Darlene Miller
PURPOSE: To report the clinical features, antibiotic susceptibility profiles, treatment, and visual acuity (VA) outcomes of endophthalmitis caused by Corynebacterium species. DESIGN: Retrospective case series. SUBJECTS: Patients with endophthalmitis caused by Corynebacterium species. METHODS: Microbiology database records were retrospectively reviewed for all patients with endophthalmitis caused by Corynebacterium species from January 1, 1990 to December 31, 2012 at a large university referral center...
May 2017: Ophthalmology Retina
https://www.readbyqxmd.com/read/28944317/comparison-of-regional-vs-general-anesthesia-for-surgical-repair-of-open-globe-injuries-at-a-university-referral-center
#20
Andrew J McClellan, Jacquelyn J Daubert, Nidhi Relhan, Kimberly D Tran, Harry W Flynn, Steven Gayer
PURPOSE: This study compares the clinical features and physician selection of either Regional Anesthesia (peribulbar or retrobulbar block) with Monitored Anesthesia Care (RA-MAC) or General Anesthesia (GA) for open globe injury repair. DESIGN: A non-randomized, comparative, retrospective case series at a University Referral Center. PARTICIPANTS: All adult repairable open globe injuries receiving primary repair between January 1st, 2004 and December 31st, 2014 (11 years)...
May 2017: Ophthalmology Retina
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