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Journal of Clinical and Translational Science

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https://www.readbyqxmd.com/read/29707261/rapid-clinical-diagnostic-variant-investigation-of-genomic-patient-sequencing-data-with-iobio-web-tools
#1
Alistair Ward, Mary A Karren, Tonya Di Sera, Chase Miller, Matt Velinder, Yi Qiao, Francis M Filloux, Betsy Ostrander, Russell Butterfield, Joshua L Bonkowsky, Willard Dere, Gabor T Marth
Introduction: Computational analysis of genome or exome sequences may improve inherited disease diagnosis, but is costly and time-consuming. Methods: We describe the use of iobio , a web-based tool suite for intuitive, real-time genome diagnostic analyses. Results: We used iobio to identify the disease-causing variant in a patient with early infantile epileptic encephalopathy with prior nondiagnostic genetic testing. Conclusions: Iobio tools can be used by clinicians to rapidly identify disease-causing variants from genomic patient sequencing data...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707260/can-composite-digital-monitoring-biomarkers-come-of-age-a-framework-for-utilization
#2
REVIEW
Christopher Kovalchick, Rhea Sirkar, Oliver B Regele, Lampros C Kourtis, Marie Schiller, Howard Wolpert, Rhett G Alden, Graham B Jones, Justin M Wright
Introduction: The application of digital monitoring biomarkers in health, wellness and disease management is reviewed. Harnessing the near limitless capacity of these approaches in the managed healthcare continuum will benefit from a systems-based architecture which presents data quality, quantity, and ease of capture within a decision-making dashboard. Methods: A framework was developed which stratifies key components and advances the concept of contextualized biomarkers...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707259/effectiveness-and-cost-of-recruiting-healthy-volunteers-for-clinical-research-studies-using-an-electronic-patient-portal-a-randomized-study
#3
Mary H Samuels, Robert Schuff, Peter Beninato, Adriel Gorsuch, James Dursch, Sarah Egan, Bridget Adams, Kate F Hollis, Rachel Navarro, Timothy E Burdick
Introduction: It is not clear how to effectively recruit healthy research volunteers. Methods: We developed an electronic health record (EHR)-based algorithm to identify healthy subjects, who were randomly assigned to receive an invitation to join a research registry via the EHR's patient portal, letters, or phone calls. A follow-up survey assessed contact preferences. Results: The EHR algorithm accurately identified 858 healthy subjects. Recruitment rates were low, but occurred more quickly via the EHR patient portal than letters or phone calls (2...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707258/improving-readability-of-informed-consents-for-research-at-an-academic-medical-institution
#4
Kristie B Hadden, Latrina Y Prince, Tina D Moore, Laura P James, Jennifer R Holland, Christopher R Trudeau
Introduction: The final rule for the protection of human subjects requires that informed consent be "in language understandable to the subject" and mandates that "the informed consent must be organized in such a way that facilitates comprehension." This study assessed the readability of Institutional Review Board-approved informed consent forms at our institution, implemented an intervention to improve the readability of consent forms, and measured the first year impact of the intervention...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707257/using-publication-data-to-evaluate-a-clinical-and-translational-science-award-ctsa-career-development-program-early-outcomes-from-kl2-scholars
#5
Noelia Sayavedra, Janice A Hogle, D Paul Moberg
Introduction: This study uses KL2 scholars' publications to evaluate the types of research the KL2 program supports and to assess the initial productivity and impact of its scholars. Methods: We illustrate the feasibility of 3 different approaches to bibliometrics, one viable method for determining the types of research a program or hub supports, and demonstrate how these data can be further combined with internal data records. Results: Gender differences were observed in the types of research scholars undertake...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707256/a-content-analysis-of-clinical-and-translational-science-award-ctsa-strategies-for-communicating-about-clinical-research-participation-online
#6
Elizabeth Flood-Grady, Samantha R Paige, Nicki Karimipour, Paul A Harris, Linda B Cottler, Janice L Krieger
Introduction: There is a dearth of literature providing guidance on how to effectively communicate about clinical research (CR). Methods: Using the transactional model of communication, a content analysis of the investigator (n=62) and participant (n=18) Web sites of institutions funded through the National Institutes of Health Clinical and Translational Science Award (CTSA) was conducted to identify their strategies (e.g., messages) for communicating about CR participation...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707255/research-coordinator-networks-and-support-models-among-academic-health-centers-in-the-ctsa-consortium
#7
Sylvia Baedorf Kassis, Sabune Winkler, Min J Gianforti, Nancy A Needler
Introduction: Research coordinators (RCs) are vital to the clinical research enterprise, ensuring research is conducted ethically, results are scientifically sound and human research subjects are protected. Given the absence of a prior systematic inquiry, we sought to understand the ways in which Clinical & Translational Science Award-funded academic health centers support RCs. Methods: Our survey asked questions about existing coordinator networks and where none existed, collected data on the characterization of resources and services provided to support RCs (outside of salary)...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707254/parenting-stress-and-dna-methylation-among-african-americans-in-the-intergen-study
#8
Michelle L Wright, Yunfeng Huang, Qin Hui, Kevin Newhall, Cindy Crusto, Yan V Sun, Jacquelyn Y Taylor
Introduction: General life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother-child dyads. Methods: We evaluated epigenome-wide DNA methylation relative to parenting stress in 74 mother-child dyads using linear mixed models...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707253/rrapp-a-robust-randomization-app-for-clinical-and-translational-research
#9
Chengcheng Tu, Emma K T Benn
While junior clinical researchers at academic medical institutions across the US often desire to be actively engaged in randomized-clinical trials, they often lack adequate resources and research capacity to design and implement them. This insufficiency hinders their ability to generate a rigorous randomization scheme to minimize selection bias and yield comparable groups. Moreover, there are limited online user-friendly randomization tools. Thus, we developed a free robust randomization app (RRApp). RRApp incorporates 6 major randomization techniques: simple randomization, stratified randomization, block randomization, permuted block randomization, stratified block randomization, and stratified permuted block randomization...
December 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29862058/the-research-to-practice-continuum-development-of-an-evidence-based-visual-aid-to-improve-informed-consent-for-procedural-sedation
#10
M Fernanda Bellolio, Lucas Oliveira J E Silva, Henrique Alencastro Puls, Ian G Hargraves, Daniel Cabrera
In order to fully participate in informed consent, patients must understand what it is that they agreeing, or not agreeing, to. In most cases, patients look to their clinicians to help develop the appropriate understanding required to give informed consent. Using a visual aid as an adjunct to risk communication in a stressful setting as the Emergency Department has a clear potential in facilitating the communication process.
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707252/a-model-for-academic-institution-support-for-community-engaged-research
#11
Dennis P Scanlon, Laura J Wolf, Cynthia H Chuang, Jennifer L Kraschnewski, Eugene J Lengerich, Susan M McHale, Ian M Paul, Janice Penrod
No abstract text is available yet for this article.
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707251/towards-a-practical-model-for-community-engagement-advancing-the-art-and-science-in-academic-health-centers
#12
Syed M Ahmed, Sharon Neu Young, Mia C DeFino, Zeno Franco, David A Nelson
Introduction: Community engagement (CE) has become more prevalent among academic health centers (AHCs), with significant diversity in practices and language. The array of approaches to CE contributes to confusion among practitioners. Methods: We have reviewed multiple models of CE utilized by AHCs, Clinical and Translational Science Awards, and higher education institutions overall. Taking these models into consideration, we propose a comprehensive model of CE that encompasses a broader spectrum of activities and programs...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707250/the-innovation-scorecard-for-continuous-improvement-applied-to-translational-science
#13
Joseph A Kotarba, Kevin Wooten
Introduction: This paper reports on the baseline stage of a qualitative evaluation of the application of the Innovative Scorecard (ISC) to the Clinical and Translational Science Award (CTSA) at the University of Texas Medical Branch (UTMB) at Galveston. The ISC is adopted from the established Balanced Scorecard system for strategic planning and performance management. In formulating the evaluation, we focused on the organizational identity literature. Methods: The initial evaluation consisted of a series of semi-structured interviews with 22 participants of the ISC Boot Camp conducted in July 2015...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707249/the-purdue-extension-and-indiana-ctsi-s-community-health-partnerships-collaboration-an-innovative-generalizable-state-wide-model-to-help-communities-build-a-culture-of-health
#14
Dennis A Savaiano, Krystal H Lynch, Donna J Vandergraff, Sarah E Wiehe, Lisa K Staten, Douglas K Miller
The Indiana Clinical and Translational Sciences Institute's Community Engagement Partners-Purdue Extension collaborative model demonstrates tremendous potential for creating state-wide programmatic efforts and improvements in both the health culture and status of Indiana residents across the state. It can serve as a prototype not only for others interested in pursuing wide geographic health improvements through Clinical and Translational Sciences Award-Cooperative Extension partnerships but also for broader collaborations among United States Department of Agriculture, National Institutes of Health, Centers for Disease Control and Prevention, state and local health departments, and health foundation efforts to improve population health...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707248/training-in-patient-centered-outcomes-research-for-specific-researcher-communities
#15
Douglas P Landsittel, Larry Kessler, Christopher H Schmid, Paul Marantz, Maria E Suarez-Almazor
A number of publications have discussed approaches to training the scientific workforce in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). To meet this need, funders have offered resources for developing educational materials and establishing training programs. To extend these efforts into specific researcher communities, the Agency for Healthcare Research and Quality developed an R25 Funding Opportunity Announcement that called for basic, advanced, and experiential training for a specific researcher community in collaboration with associated program partners...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29707247/-fast-pace-train-the-trainer-a-scalable-new-educational-program-to-accelerate-training-in-biomedical-innovation-entrepreneurship-and-commercialization
#16
Jonathan Servoss, Connie Chang, Jonathan Fay, Kanchan Sehgal Lota, George A Mashour, Kevin R Ward
Introduction: The Institute of Medicine recommended the advance of innovation and entrepreneurship training programs within the Clinical & Translational Science Award (CTSA) program; however, there remains a gap in adoption by CTSA institutes. The University of Michigan's Michigan Institute for Clinical & Health Research and Fast Forward Medical Innovation (FFMI) partnered to develop a pilot program designed to teach CTSA hubs how to implement innovation and entrepreneurship programs at their home institutions...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29503735/the-evolving-collaborative-relationship-between-practice-based-research-networks-pbrns-and-clinical-and-translational-science-awardees-ctsas
#17
Maureen Riley-Behringer, Melinda M Davis, James J Werner, L J Fagnan, Kurt C Stange
Purpose: Clinical and Translational Science Awards (CTSAs) and Practice-based Research Networks (PBRNs) have complementary missions. We replicated a 2008 survey of CTSA-PBRN leaders to understand how organizational relationships have evolved. Methods: We surveyed 60 CTSA community engagement (CE) Directors and 135 PBRN Directors and analyzed data using between and within-group comparisons. Results: Forty-three percent of CTSA CE Directors (26/60) and forty-two percent of PBRN Directors (57/135) responded...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29456873/the-rockefeller-university-clinical-scholars-kl2-program-2006-2016
#18
Sarah J Schlesinger, Michelle Romanick, Jonathan N Tobin, Donna Brassil, Rhonda G Kost, Rita Devine, Barbara O'Sullivan, Roger D Vaughan, Yupu Liang, Joel Correa da Rosa, Maija Williams, James G Krueger, Barry S Coller
Introduction and Methods: The Rockefeller Clinical Scholars (KL2) Program began in 1976 and transitioned into a 3-year Master's degree program in 2006 when Rockefeller joined the NIH Clinical and Translational Science Award (CTSA) program. The program consists of ~15 trainees supported by the CTSA KL2 award and University funds. It is designed to provide an optimal environment for junior translational investigators to develop team science and leadership skills by designing and performing a human subjects protocol under the supervision of a distinguished senior investigator mentor and a team of content expert educators...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29430304/all-nurses-need-to-be-research-nurses
#19
Patricia Eckardt, Marilyn J Hammer, Margaret Barton-Burke, Margaret McCabe, Christine T Kovner, Liza Behrens, Heather Reens, Barry S Coller
Introduction: Nurses are critical to the research enterprise. However all nurses are not prepared to participate as members of the research team since education and training in clinical research nursing and nurse-specific Good Clinical Practice are not consistently included in nursing curricula. The lack of nurse education and training in clinical research and Good Clinical Practice leaves research participants vulnerable with a nursing workforce that is not prepared to balance fidelity to protocol and patient quality care and safety...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29657863/fluid-resuscitation-associated-increased-mortality-and-inflammatory-cytokine-expression-in-murine-polymicrobial-sepsis
#20
Young Im Lee, Robert L Smith, Erin J Caraher, George Crowley, Syed Hissam Haider, Sophia Kwon, Anna Nolan
No abstract text is available yet for this article.
August 2017: Journal of Clinical and Translational Science
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