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Journal of Gynecology Obstetrics and Human Reproduction

Naina Kumar, Amit Kant Singh
Male factor is responsible for 40-50% of infertility cases, contributing equally as a female factor. Oxidative stress has now emerged as one of the major causes of unexplained male infertility, as it leads to increased risk of Deoxyribonucleic acid (DNA) fragmentation, decreased sperm motility, concentration and abnormal morphology. Though a certain amount of reactive oxygen species (ROS) activity is essential for normal functioning of sperms, an excess lead to pathological effects on semen parameters, ultimately resulting in male sub-fertility or infertility...
July 14, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Anne-Sophie Gremeau, Marion Corvaisier, Nicolas Bourdel, Michel Canis, Denis Gallot, Jean Luc Pouly
INTRODUCTION: The purpose of this study is to report on our experience of laparoscopic cervico-isthmic cerclage. MATERIAL AND METHOD: A monocentric retrospective study covering a 13-year period during which 25 cases of laparoscopic cerclage outside of pregnancy were performed, using the technique described by Dubuisson, at the University Hospital of Clermont-Ferrand. Individual patient data included pregnancy outcomes before and after cerclage and the characteristics of surgery...
July 7, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Iolanda João Mora Cruz Freitas Ferreira, Filipa Sousa, Elsa Marques Vasco, Ana Luísa Fialho de Amaral Areia, José Paulo Achando Silva Moura
Immune thrombocytopenia (ITP) during pregnancy is an acquired autoimmune disease present in 1-2 of every 1000 pregnancies. Thrombopoietin (TPO)-mimetic drugs, such as eltrombopag, have been successfully used for treatment of ITP during pregnancy, but studies regarding its safety during gestation are lacking. A 33-year-old nulliparous woman with a history of chronic ITP, presented at the emergency department with petechiae, epistaxis, bruises, conjunctival effusions and a platelet count of 3×109 /L at 25 weeks gestation...
July 4, 2018: Journal of gynecology obstetrics and human reproduction
Etienne Charpentier, Erick Petit, Sophie Beranger, Arshid Azarine
Endometriosis is a condition where hormonal-responsive endometrial tissue grows outside the uterus usually within the pelvic cavity. Extra-pelvic endometriosis is rare and may involve the pericardium. We report the first case of pericardial endometriosis suspected using cardiac magnetic resonance imaging.
July 4, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Sami Haddad, Aude Arnaud, Sylvie Maurice, Sophie Pueyo
CONTEXT: Precariousness is increasing among all populations and especially among women. The access to healthcare is increasingly unequal upon the population and particularly in access to contraception methods or abortion according to their vulnerability level. OBJECTIVE: Our main object is to describe the socio-demographic specifications, the different steps involved in the healthcare itinerary to contraception and abortion, according to the level of social vulnerability for a woman population sample requesting an abortion...
June 26, 2018: Journal of Gynecology Obstetrics and Human Reproduction
P Benoist, A Mureau, Y Joueidi, F Arbion, A Vilde, G Body, P Michenet, J Leveque, L Ouldamer
PURPOSE: The aim of the study was to investigate the management and prognosis of Pure primary squamous cell carcinoma (PPSCC) of the breast. MATERIALS AND METHODS: This study is a multicentre retrospective cohort from three French tertiary referral hospitals (Rennes, Orléans and Tours) including all women treated for a PPSCC of the breast defined by squamous cells that could contain a minority of sarcomatoid component. We excluded carcinomas with a ductual component...
June 26, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Athiel Yoann, Barrois Mathilde, Bault Jean-Philippe, Cohen Laurence, Leroy Brigitte, Quibel Thibaud
Congenital ventricular aneurysms and diverticula are rare congenital heart diseases, currently accessible to prenatal diagnosis. Information on the natural course of ventricular aneurysm or diverticulum detected during fetal life is limited as there are only few case reports and case series enumerating the defect. We aimed to describe through three cases, the prenatal features and clinical outcomes of fetal cardiac aneurysms. The first one was diagnosed during the second trimestrer and spontaneous evolution was favorable...
June 19, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Philippe Ferry, Pauline Bertherat, Anne Gauthier, Richard Villet, Francesco Del Piano, David Hamid, Hervé Fernandez, Pierre-Louis Broux, Delphine Salet-Lizée, Etienne Vincens, Pierre Ntshaykolo, Philippe Debodinance, Philippe Pocholle, Yannick Thirouard, Renaud de Tayrac
Vaginal mesh safety information is limited, especially concerning single incision techniques using ultra lightweight meshes for the treatment of anterior pelvic organ prolapse (POP). Objective To determine the intraoperative and postoperative complication rates after anterior POP repair involving an ultralight mesh (19kg/m2 ): Restorelle® Direct Fix™. Methods A case series of 218 consecutive patients, operated on between January 2013 and December 2016 in ten tertiary and secondary care centres, was retrospectively analysed...
June 16, 2018: Journal of gynecology obstetrics and human reproduction
P Collinet, X Fritel, C Revel-Delhom, M Ballester, P A Bolze, B Borghese, N Bornsztein, J Boujenah, T Brillac, N Chabbert-Buffet, C Chauffour, N Clary, J Cohen, C Decanter, A Denouël, G Dubernard, A Fauconnier, H Fernandez, T Gauthier, F Golfier, C Huchon, G Legendre, J Loriau, E Mathieu-d'Argent, B Merlot, J Niro, P Panel, P Paparel, C A Philip, S Ploteau, C Poncelet, B Rabischong, H Roman, C Rubod, P Santulli, M Sauvan, I Thomassin-Naggara, A Torre, J M Wattier, C Yazbeck, N Bourdel, M Canis
First-line diagnostic investigations for endometriosis are physical examination and pelvic ultrasound. The second-line investigations are: targeted pelvic examination performed by an expert clinician, transvaginal ultrasound performed by an expert physician sonographer (radiologist or gynaecologist), and pelvic MRI. Management of endometriosis is recommended when the disease has a functional impact. Recommended first-line hormonal therapies for the management of endometriosisrelated pain are combined hormonal contraceptives (CHCs) or the 52mg levonorgestrel-releasing intrauterine system (IUS)...
June 16, 2018: Journal of Gynecology Obstetrics and Human Reproduction
C Rubod, A Fouquet, S Bartolo, J Lepage, A Capelle, C Lefebvre, E Kamus, D Dewailly, P Collinet
INTRODUCTION: The management of posterior deep endometriosis is not consensual. This is due to a great heterogeneity of data from the literature. Many series were small and overall, predictors of pregnancy were not all included and analyzed by multivariate analysis. We conducted this study to evaluate the factors associated with pregnancy during the first two in vitro fertilization (IVF) attempts in infertile women with posterior deep endometriosis. MATERIAL AND METHODS: 230 women were included in this retrospective observational study, between January 1th, 2007 and September 30th, 2013, at the University Hospital of Lille...
June 14, 2018: Journal of gynecology obstetrics and human reproduction
Levent Dikbas, Riza Dur, İsmail Hakkı Tas, Ömer Erkan Yapça, Neslihan Dikbas
OBJECTIVE: Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time. MATERIALS AND METHODS: We measured the transcriptional levels of the PON2 and PON3 enzymes in the curettage materials obtained from the patients with unexplained recurrent abortus (n=25) and compared the results with those measured in the abortus materials from healthy pregnant women (n=50) who had undergone a voluntary abortion...
June 14, 2018: Journal of Gynecology Obstetrics and Human Reproduction
M Rousseau, A Morel, S Dechoux, P E Bouet, L Catala, C Lefebvre Lacoeuille, Ph Descamps, G Legendre
OBJECTIVES: The objective of this literature review is to reiterate the epidemiology, clinical signs, and radiological signs that should be consistent with a uterine sarcoma as well as the precautionary pre- and postoperative principles that help prevent morcellation of uterine sarcomas when treating patients with uterine fibroids. METHOD: We conducted this literature review by consulting the Pubmed, Medline, and Cochrane Systematic Review databases up to 28/02/2017 using the following keywords: fibroid, myoma, leiomyoma, sarcoma, leiosarcoma, uterine cancer, myomectomy, hysterectomy, morcellation, and uterine morcellation...
June 4, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Clara Piffaretti, Vincent Looten, Sylvie Rey, Jeanne Fresson, Anne Fagot-Campagna, Philippe Tuppin
OBJECTIVE: This study was designed to further our knowledge of the management of pregnant women based on the national health data system (SNDS). MATERIAL AND METHODS: Women covered by the national health insurance general scheme or a local mutualist section, who delivered in 2015. RESULTS: Among the 672,182 women included (mean age: 31 years, SD 5.3), 0.3% were under the age of 18 years, 4% lived in a French overseas department (<18 years: 21%), 17% had complementary universal health insurance coverage (<18 years: 75%), 1...
June 2, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Mahmut Çay, Aymelek Çetin, Mustafa Ateş, Işıl Köleli, Deniz Şenol, Evren Köse, Dinçer Özgör, Arife Şimşek, Davut Özbağ
OBJECTIVE: This study was conducted to evaluate the effect of vaginal delivery and aging on anal sphincter anatomy and function. METHOD: Asymptomatic thirty women were included in this prospective study. Group 1 included 10 women (age range: 18-50) who had never been pregnant. Group 2 included 10 women (age range: 18-50) who had vaginal delivery. Group 3 included 10 women over 50 who had vaginal delivery. RESULTS: There was no statistically significant difference between the three groups in terms of resting and squeeze pressures...
May 30, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Engin Korkmazer, Rampia Nizam, Emine Arslan, Özgür Akkurt
INTRODUCTION: Morbidly adherent placenta is a clinical condition of which prevalance is steadily increasing. It is described as the invasion of the placenta into the uterine wall through the myometrium and beyond. Vascular cell adhesion molecule-1 is a calcium independent transmembrane glycoprotein. Several studies have shown that vascular cell adhesion molecule-1 increases invasion in tumor cells. In our study we investigated the expression of vascular cell adhesion molecule-1 which has been shown to increase invasion in various tumors in morbidly adherent placenta cases...
May 29, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Pauline Chauvet, Candy Guiguet-Auclair, Aurélie Comptour, Amélie Denouël, Laurent Gerbaud, Michel Canis, Nicolas Bourdel
INTRODUCTION: Endometriosis symptoms may have a negative effect on health-related quality of life (HRQoL). Analyses of open comments are known to be a key source of information and support. The authors aimed to analyse open comments associated with a validation scale study, in order to ascertain whether the questionnaires allowed an adequate exploration of patient preoccupations and in so doing define important quality of life themes not assessed in HRQoL scales. MATERIAL AND METHODS: Analysis of open comments, following two questionnaires (SF-36 and EHP-30) as part of a national study evaluating the EHP-30, was performed...
May 25, 2018: Journal of gynecology obstetrics and human reproduction
C H Bretagne, V Jooste, D Guenat, D Riethmuller, A M Bouvier, I Bedgedjian, J L Prétet, S Valmary-Degano, C Mougin
BACKGROUND: Despite the availability of safe and effective HPV vaccines in France, more than 80% of girls remain unvaccinated. SETTING: A regional university hospital referral center in France. OBJECTIVE: To estimate the overall prevalence and distribution of HPV in vaccinated, sexually active young French women who were screened for cervical cancer by cytology and HPV testing. METHODS: High-risk HPV (HR-HPV) prevalence, genotype-specific prevalence and extent of multiple infections were assessed in 125 cervical samples from females with available vaccine data using hc2 assay and INNO-LiPA assay...
May 25, 2018: Journal of Gynecology Obstetrics and Human Reproduction
P Coste Mazeau, Y Aubard, V Aubard, S Martin, L Bejjani, C Yardin
Prenatal diagnosis of cystic fibrosis (CF) is difficult and is mainly considered upon identification of digestive sonographic signs. Although such an association has never been described until now to our knowledge, we report two cases of fetal arrhythmia associated with cystic fibrosis. This association may be explained by the physiopathology of heart in the context of CF, but nevertheless needs to be confirmed by other reports. The prenatal diagnosis of CF is important in order to implement early appropriate care, with better prognosis...
May 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Audrey Fleury, Olivier Pirrello, Christine Maugard, Carole Mathelin, Christelle Linck
INTRODUCTION: Ovarian tissue cryopreservation is a modern technique of fertility preservation, useful before using ovariotoxic therapies in the treatment of breast cancer. The aim of our literature review was to study ovarian cryopreservation experiences for women with breast cancer, to identify guidelines, constraints and results in the oncological and obstetrical fields. METHODS: We searched articles through the PubMed/Medline database, including all French and English references from January 2000 to October 2017...
May 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
S Desurmont, A Houzé de l'Aulnoit, G Brabant, D Houzé de l'Aulnoit
PURPOSE: Engagement of the fetal head is a determinant element when deciding on operative vaginal delivery. In routine practice, engagement is a clinical diagnosis based on transvaginal digital examination. Transperineal ultrasound might provide complementary information useful for measuring the fetal head-perineum distance (HPD). The purpose of this work was to determine the cutoff HPD distinguishing engagement from non-engagement. MATERIALS AND METHODS: This single-center prospective study approved by the institutional review board was conducted between December 25, 2012 and August 31, 2015 in 411 nulliparous women; 20 did not provide informed consent and were excluded; analysis concerned 391 patients...
May 21, 2018: Journal of Gynecology Obstetrics and Human Reproduction
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