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Birth Defects Research

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https://www.readbyqxmd.com/read/29921033/surveillance-of-microcephaly-and-selected-brain-anomalies-in-argentina-relationship-with-zika-virus-and-other-congenital-infections
#1
Ana Laura Tellechea, Victoria Luppo, María Alejandra Morales, Boris Groisman, Agustin Baricalla, Cintia Fabbri, Anabel Sinchi, Alicia Alonso, Cecilia Gonzalez, Bibiana Ledesma, Patricia Masi, María Silva, Adriana Israilev, Marcela Rocha, Marcela Quaglia, María Paz Bidondo, Rosa Liascovich, Pablo Barbero
BACKGROUND: Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. METHODS: Participants were enrolled between April 2016 and March 2017. CASES: newborns from the National Network of Congenital Abnormalities of Argentina (RENAC) with head circumference lower than the 3rd percentile according to gestational age and sex, or selected brain anomalies...
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29921029/bone-development-in-laboratory-mammals-used-in-developmental-toxicity-studies
#2
REVIEW
John M DeSesso, Anthony R Scialli
Evaluation of the skeleton in laboratory animals is a standard component of developmental toxicology testing. Standard methods of performing the evaluation have been established, and modification of the evaluation using imaging technologies is under development. The embryology of the rodent, rabbit, and primate skeleton has been characterized in detail and summarized herein. The rich literature on variations and malformations in skeletal development that can occur in the offspring of normal animals and animals exposed to test articles in toxicology studies is reviewed...
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29921024/brca1-and-brca2-gene-variants-and-nonsyndromic-cleft-lip-palate
#3
Nicholas Rodriguez, Lorena Maili, Brett T Chiquet, Susan H Blanton, Jacqueline T Hecht, Ariadne Letra
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a debilitating condition that not only affects the individual, but the entire family. The purpose of this study was to investigate the association of BRCA1 and BRCA2 genes with NSCL/P. METHODS: Twelve polymorphisms in/nearby BRCA1 and BRCA2 were genotyped using Taqman chemistry. Our data set consisted of 3,473 individuals including 2,191 nonHispanic white (NHW) individuals (from 151 multiplex and 348 simplex families) and 1,282 Hispanic individuals (from 92 multiplex and 216 simplex families)...
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29921022/future-of-3d-printing-how-3d-bioprinting-technology-can-revolutionize-healthcare
#4
REVIEW
Steven Morris
Currently there are more than 2,000 children on the transplant waiting list-and more than 100,000 Americans nationwide-awaiting a matching organ. Most children aged one through 10 are awaiting a kidney, liver, or heart. As with any transplant, there are two ways to find an organ-someone can donate or someone can die. Unfortunately, the supply falls far short of the demand, leaving people to die every day waiting for a second chance at life. Scientific and medical experts, however, continue to develop promising technology like 3D bioprinting that could save thousands of lives without the need of a donor...
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29917322/sea-water-desalination-a-newly-discovered-cause-of-iodine-deficiency
#5
EDITORIAL
Isabella J Boroje, Gideon Koren, Steven H Lamm
No abstract text is available yet for this article.
June 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29885048/comments-on-low-carbohydrate-diets-may-increase-risk-of-neural-tube-defects
#6
LETTER
Salvador Camacho
No abstract text is available yet for this article.
June 9, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29851303/high-sucrose-low-copper-diet-in-pregnant-diabetic-rats-induces-transient-oxidative-stress-hypoxia-and-apoptosis-in-the-offspring-s-liver
#7
Zivanit Ergaz, Liza Weinstein-Fudim, Asher Ornoy
BACKGROUND: Hyperglycemia-related oxidative stress and hypoxia are important mechanisms responsible for diabetes-induced embryopathy and other complications. High sucrose low copper diet (HSD), but not regular diet (RD), induces type 2 diabetes in the inbred Cohen diabetic sensitive (CDs) rats but not in the Sabra control rats. We recently demonstrated long-term changes of DNA methylation and gene expression in various groups of genes, including genes involved in oxidant-antioxidant activity in the liver of 2-4-week-old CDs offspring of diabetic dams...
May 30, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29851302/applications-and-challenges-of-using-3d-printed-implants-for-the-treatment-of-birth-defects
#8
REVIEW
Sameera Wickramasinghe, Monica Navarreto-Lugo, Minseon Ju, Anna Cristina S Samia
Pediatric implants are a special subclass of a vast number of clinically used medical implants, uniquely designed to address the needs of young patients who are at the onset of their developmental growth stage. Given the vulnerability of the implant receiver, it is crucial that the implants manufactured for small children with birth-associated defects be given careful considerations and great attention to design detail to avoid postoperative complications. In this review, we focus on the most common types of medical implants manufactured for the treatment of birth defects originating from both genetic and environmental causes...
May 30, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29781248/the-role-of-3d-printing-in-treating-craniomaxillofacial-congenital-anomalies
#9
REVIEW
Christopher D Lopez, Lukasz Witek, Andrea Torroni, Roberto L Flores, David B Demissie, Simon Young, Bruce N Cronstein, Paulo G Coelho
Craniomaxillofacial congenital anomalies comprise approximately one third of all congenital birth defects and include deformities such as alveolar clefts, craniosynostosis, and microtia. Current surgical treatments commonly require the use of autogenous graft material which are difficult to shape, limited in supply, associated with donor site morbidity and cannot grow with a maturing skeleton. Our group has demonstrated that 3D printed bio-ceramic scaffolds can generate vascularized bone within large, critical-sized defects (defects too large to heal spontaneously) of the craniomaxillofacial skeleton...
May 20, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29762915/women-s-periconceptional-diet-and-risk-of-biliary-atresia-in-offspring
#10
Suzan L Carmichael, Chen Ma, Alissa R Van Zutphen, Cynthia A Moore, Gary M Shaw
INTRODUCTION: We examined the association of biliary atresia with maternal dietary intake, using National Birth Defects Prevention Study (NBDPS) data from 152 cases and 11,112 nonmalformed controls born 1997-2011. METHODS: NBDPS is a multisite, population-based case-control study. Exposure data were from maternal telephone interviews, which included a food frequency questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were generated from logistic regression models that included nutritional factors as continuous variables and were adjusted for energy intake only or energy intake plus covariates (maternal race-ethnicity, education, age, prepregnancy body mass index, vitamin/mineral supplement intake, conception during summer)...
May 15, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29732742/gene-variants-in-the-folate-pathway-are-associated-with-increased-levels-of-folate-receptor-autoantibodies
#11
Yuqi Dong, Linlin Wang, Yunping Lei, Na Yang, Robert M Cabrera, Richard H Finnell, Aiguo Ren
BACKGROUND: Folate receptors (FRs) facilitate embryonic uptake of folates and are important for proper early embryonic development. There is accumulating evidence that blocking FR autoantibodies contribute to developmental diseases. However, genetic factors associated with the expression of FR autoantibodies remain unknown. OBJECTIVE: We investigated the effects of genetic polymorphisms in folate pathway genes on FR autoantibody titers in women. METHODS: We recruited 302 pregnant women in China...
May 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29732722/network-correlation-analysis-revealed-potential-new-mechanisms-for-neural-tube-defects-beyond-folic-acid
#12
Xiaoya Gao, Richard H Finnell, Hongyan Wang, Yufang Zheng
BACKGROUND: Neural tube defects (NTDs) are clinically significant congenital malformations which are known to be folic acid (FA) responsive, such that supplementation significantly reduces the prevalence of NTDs. Nonetheless, some individuals fail to respond to FA supplementation; hence NTDs remain a significant public health concern. The mechanisms that underlie the beneficial effects of FA supplementation remain poorly understood. Mouse models have been used extensively to study the mechanisms driving neural tube closure (NTC)...
May 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29797554/comments-on-low-carbohydrate-diets-may-increase-risk-of-neural-tube-defects
#13
LETTER
Zoë Harcombe
No abstract text is available yet for this article.
July 3, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29797553/response-to-harcombe
#14
LETTER
Tania Desrosiers, Anna Maria Siega-Riz, Bridget Mosley, Robert Meyer
No abstract text is available yet for this article.
July 3, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29797552/response-to-camacho
#15
LETTER
Tania Desrosiers, Anna Maria Siega-Riz, Bridget Mosley, Robert Meyer
No abstract text is available yet for this article.
July 3, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29536674/development-of-growth-equations-from-longitudinal-studies-of-body-weight-and-height-in-the-full-term-and-preterm-neonate-from-birth-to-four-years-postnatal-age
#16
John A Troutman, Mary C Sullivan, Gregory J Carr, Jeffrey Fisher
Physiologically based pharmacokinetic (PBPK) models are developed from compound-independent information to describe important anatomical and physiological characteristics of an individual or population of interest. Modeling pediatric populations is challenging because of the rapid changes that occur during growth, particularly in the first few weeks and months after birth. Neonates who are born premature pose several unique challenges in PBPK model development. To provide appropriate descriptions for body weight (BW) and height (Ht) for age and appropriate incremental gains in PBPK models of the developing preterm and full term neonate, anthropometric measurements collected longitudinally from 1,063 preterm and 158 full term neonates were combined with 2,872 cross-sectional measurements obtained from the NHANES 2007-2010 survey...
July 3, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29504274/nutrient-intake-in-women-before-conception-and-risks-of-anophthalmia-and-microphthalmia-in-their-offspring
#17
Kari A Weber, Wei Yang, Suzan L Carmichael, Gary M Shaw
BACKGROUND: We previously explored associations between nutrients including folate and other macro and micronutrients and risks of anophthalmia or microphthalmia in the National Birth Defects Prevention Study. In the current study, we expand those previous results with larger sample sizes and conduct analyses with an additional diet quality index using more recent data. METHODS: The National Birth Defects Prevention Study is a population-based, multicenter case-control study of over 30 major birth defects, with estimated due dates from October 1997 to December 2011...
June 1, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29498243/nonsyndromic-cleft-palate-an-association-study-at-gwas-candidate-loci-in-a-multiethnic-sample
#18
Nina Ishorst, Paola Francheschelli, Anne C Böhmer, Mohammad Faisal J Khan, Stefanie Heilmann-Heimbach, Nadine Fricker, Julian Little, Regine P M Steegers-Theunissen, Borut Peterlin, Stefanie Nowak, Markus Martini, Teresa Kruse, Anton Dunsche, Thomas Kreusch, Lina Gölz, Khalid Aldhorae, Esam Halboub, Heiko Reutter, Peter Mossey, Markus M Nöthen, Michele Rubini, Kerstin U Ludwig, Michael Knapp, Elisabeth Mangold
BACKGROUND: Nonsyndromic cleft palate only (nsCPO) is a common and multifactorial form of orofacial clefting. In contrast to successes achieved for the other common form of orofacial clefting, that is, nonsyndromic cleft lip with/without cleft palate (nsCL/P), genome wide association studies (GWAS) of nsCPO have identified only one genome wide significant locus. Aim of the present study was to investigate whether common variants contribute to nsCPO and, if so, to identify novel risk loci...
June 1, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29460393/embryo-fetal-development-studies-with-the-dietary-supplement-vinpocetine-in-the-rat-and-rabbit
#19
Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
Dietary supplement and natural product use is increasing within the United States, resulting in growing concern for exposure in vulnerable populations, including young adults and women of child-bearing potential. Vinpocetine is a semisynthetic derivative of the Vinca minor extract, vincamine. Human exposure to vinpocetine occurs through its use as a dietary supplement for its purported nootropic and neuroprotective effects. To investigate the effects of vinpocetine on embryo-fetal development, groups of 25 pregnant Sprague-Dawley rats and 8 pregnant New Zealand White rabbits were orally administered 0, 5, 20, or 60 mg vinpocetine/kg and 0, 25, 75, 150, or 300 mg/kg daily from gestational day (GD) 6-20 and GD 7-28, respectively...
June 1, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29446255/potential-genetic-markers-for-nonsyndromic-oral-clefts-in-the-brazilian-population-a-systematic-review-and-meta-analysis
#20
REVIEW
Renato Assis Machado, Isabela Porto de Toledo, Hercilio Martelli-Júnior, Silvia Regina Reis, Eliete Neves Silva Guerra, Ricardo D Coletta
BACKGROUND: Although various genes and genomic regions were described as of susceptibility for nonsyndromic oral clefts (NOC), recent reports have demonstrated significant interethnic variations in the genetic predisposition, a situation that affects the Brazilian population, one of the most admixed populations in the world. Therefore, the purpose of this review was to describe the available information on genetic risk markers for NOC in the Brazilian population. METHODS: A systematic search of the literature was performed using LILACS, LIVIVO, PubMed, Scopus, and Web of Science databases, and studies that investigated genetic susceptibility markers for NOC in the Brazilian population were retrieved...
June 1, 2018: Birth Defects Research
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