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Birth Defects Research

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https://www.readbyqxmd.com/read/30421543/overview-on-neural-tube-defects-from-development-to-physical-characteristics
#1
REVIEW
Laura Avagliano, Valentina Massa, Timothy M George, Sarah Qureshy, Gaetano Pietro Bulfamante, Richard H Finnell
Neural tube defects (NTDs) are the second most common congenital malformations in humans affecting the development of the central nervous system. Although NTD pathogenesis has not yet been fully elucidated, many risk factors, both genetic and environmental, have been extensively reported. Classically divided in two main sub-groups (open and closed defects) NTDs present extremely variable prognosis mainly depending on the site of the lesion. Herein, we review the literature on the histological and pathological features, epidemiology, prenatal diagnosis, and prognosis, based on the type of defect, with the aim of providing important information based on NTDs classification for clinicians and scientists...
November 12, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30411533/maternal-hypertension-and-hypospadias-in-offspring-a-systematic-review-and-meta-analysis
#2
REVIEW
Fatima R Sheriff, Adriana Lopez, Philip J Lupo, Abhishek Seth, Carolina Jorgez, A J Agopian
BACKGROUND: Several studies have reported an association between maternal hypertensive disorders and hypospadias in offspring; however there is still debate on the role of maternal hypertension and preeclampsia on this relatively common congenital malformation. Therefore, we conducted a systematic review and meta-analysis to comprehensively evaluate the relationship between these frequent maternal conditions and hypospadias in offspring. METHODS: Fifteen articles meeting the eligibility criteria were identified in our search and included in the analysis...
November 8, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30403011/the-national-spina-bifida-patient-registry-a-decade-s-journey
#3
Jonathan Castillo, Philip J Lupo, Duong D Tu, A J Agopian, Heidi Castillo
BACKGROUND: The National Spina Bifida Patient Registry (NSBPR) was established in 2008, as a partnership between the CDC and spina bifida (SB) clinics throughout the United States. The purpose of this study is to explore the initial work of this project through a literature review of published studies from the NSBPR and provide a description of how this body of literature has developed overtime. METHODS: We included studies indexed in MEDLINE by means of PubMed from January 2009 through April 2018...
November 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30403010/population-based-birth-defects-surveillance-epidemiology-and-public-health-practice
#4
EDITORIAL
Russell S Kirby, Marilyn L Browne
No abstract text is available yet for this article.
November 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30403007/study-of-selected-birth-defects-among-american-indian-alaska-native-population-a-multi-state-population-based-retrospective-study-1999-2007
#5
Lisa K Marengo, Timothy J Flood, Mary K Ethen, Russell S Kirby, Sarah Fisher, Glenn Copeland, Robert E Meyer, Julie Dunn, Mark A Canfield, Tom Anderson, Del Yazzie, Cara T Mai
BACKGROUND: Higher prevalence of selected birth defects has been reported among American Indian/Alaska Native (AI/AN) newborns. We examine whether known risk factors for birth defects explain the higher prevalence observed for selected birth defects among this population. METHODS: Data from 12 population-based birth defects surveillance systems, covering a birth population of 11 million from 1999 to 2007, were used to examine prevalence of birth defects that have previously been reported to have elevated prevalence among AI/ANs...
November 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30402975/maternal-genitourinary-infections-and-risk-of-birth-defects-in-the-national-birth-defects-prevention-study
#6
Meredith M Howley, Marcia L Feldkamp, Eleni A Papadopoulos, Sarah C Fisher, Kathryn E Arnold, Marilyn L Browne
BACKGROUND: Genitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs. METHODS: Using data from the National Birth Defects Prevention Study, a multisite, population-based, case-control study, we assessed self-reported maternal GUIs in the month before through the third month of pregnancy (periconception) from 29,316 birth defect cases and 11,545 unaffected controls. We calculated odds ratios (ORs) and 95% confidence intervals to estimate the risk of 52 major structural birth defects associated with GUIs...
November 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30402937/understanding-the-participation-of-grem1-polymorphisms-in-nonsyndromic-cleft-lip-with-or-without-cleft-palate-in-the-brazilian-population
#7
Camila Sane Viena, Renato Assis Machado, Darlene Camati Persuhn, Hercílio Martelli-Júnior, Alena Peixoto Medrado, Ricardo D Coletta, Silvia R A Reis
BACKGROUND: GREM1, which encodes Gremlin 1, an antagonist of bone morphogenic proteins with effects on proliferation and apoptosis, has been considered a candidate gene for nonsyndromic cleft lip with or without cleft palate (NSCL±P). In this study, we investigated potential associations of single nucleotide polymorphisms (SNP) in GREM1 and NSCL±P risk in the Brazilian population. Additionally, SNP-SNP interactions of GREM1 with previously reported rs1880646 variant in NTN1 (netrin 1), a gene also responsible for apoptotic phenotypes were verified...
November 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30394691/population-based-surveillance-of-congenital-heart-defects-among-adolescents-and-adults-surveillance-methodology
#8
Jill Glidewell, Wendy Book, Cheryl Raskind-Hood, Carol Hogue, Julie E Dunn, Michelle Gurvitz, Al Ozonoff, Claire McGarry, Alissa Van Zutphen, George Lui, Karrie Downing, Tiffany Riehle-Colarusso
BACKGROUND: Improved treatment of congenital heart defects (CHDs) has increased survival of persons with CHDs; however, no U.S. population-based systems exist to assess prevalence, healthcare utilization, or longer-term outcomes among adolescents and adults with CHDs. METHODS: Novel approaches identified individuals aged 11-64 years who received healthcare with ICD-9-CM codes for CHDs at three sites: Emory University in Atlanta, Georgia (EU), Massachusetts Department of Public Health (MA), New York State Department of Health (NY) between January 1, 2008 (2009 for MA) and December 31, 2010...
November 5, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30381912/resolution-of-unexpected-pregnancy-related-findings-in-a-rat-embryofetal-development-and-toxicokinetic-study-of-monoclonal-antibodies-specific-for-hcmv
#9
Paula Katavolos, Rodney Prell, Doris Zane, Rong Deng, Wendy Halpern
BACKGROUND: Developmental and reproductive toxicity testing is not uniformly warranted for biopharmaceuticals that lack relevant targets in test species. However, RG7667, consisting of two monoclonal antibodies specific for human cytomegalovirus (hCMV), was intended for administration to pregnant women to prevent transmission of CMV to the developing fetus. METHODS: Considering the target indication, a Pilot Embryo Fetal Development/Toxicokinetic study was conducted to assess toxicokinetics in the dam and fetuses and general tolerability...
October 31, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30378744/gestational-age-and-socioeconomic-status-as-mediators-for-the-impact-of-prenatal-alcohol-exposure-on-development-at-6-months
#10
Claire D Coles, Julie A Kable, Irina V Granovska, Ala O Pashtepa, Larisa D Plotka, Victor B Dolhov, Wladimir Wertelecki, Kenneth L Jones, Christina D Chambers
BACKGROUND: Of the many negative outcomes associated with gestational alcohol use, one that has received relatively little attention is preterm birth and its possible contribution to effects of prenatal alcohol exposure (PAE) on development. To examine the increased risk for premature delivery associated with PAE and the joint influence of preterm birth and alcohol on child outcomes, analysis was carried out in a longitudinal cohort recruited in Western Ukraine. METHODS: Alcohol-using women and low or nondrinking controls were identified prenatally for a clinical trial of multivitamins and minerals (MVM) in ameliorating effects of PAE...
October 31, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30367712/maternal-arsenic-exposure-and-nonsyndromic-orofacial-clefts
#11
Jonathan Suhl, Stephanie Leonard, Peter Weyer, Anthony Rhoads, Anna Maria Siega-Riz, T Renée Anthony, Trudy L Burns, Kristin M Conway, Peter H Langlois, Paul A Romitti
BACKGROUND: Arsenic is widely distributed in the environment in both inorganic and organic forms. Evidence from animal studies suggests that maternal inorganic arsenic may lead to the development of orofacial clefts (OFC)s in offspring. This evidence, together with the limited epidemiologic data available, supports the need for a comprehensive examination of major sources of arsenic exposure and OFCs in humans. METHODS: Using interview data collected in the National Birth Defects Prevention Study, public and well water arsenic sampling data, and dietary arsenic estimates, we compared expert-rater assessed occupational arsenic exposure, individual-level exposure to arsenic through drinking water, and dietary arsenic exposure between mothers of OFC cases (N = 435) and unaffected controls (N = 1267)...
October 27, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30367709/pdgfr%C3%AE-monoclonal-antibody-assessment-of-embryo-fetal-toxicity-and-time-dependent-placental-transfer-of-a-murine-surrogate-antibody-of-olaratumab-in-mice
#12
Debra Luffer-Atlas, Vijayapal R Reddy, Kim G Hilbish, Curtis E Grace, William J Breslin
BACKGROUND: Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. The maternal and in utero embryo-fetal toxicity and toxicokinetics of a human anti-mouse PDGFRα antibody (LSN3338786) were investigated in pregnant mice. METHODS: A pilot study was used to set doses for the definitive study. In the definitive study, mice were administered vehicle, 5, 50, or 150 mg/kg LSN3338786 by intravenous injection on gestation days (GD) 6, 9, 12, and 15...
October 27, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30362293/comments-on-embryo-fetal-development-studies-with-the-dietary-supplement-vinpocetine-in-the-rat-and-rabbit-catlin-et-al-birth-defects-research-2018-110-883-896
#13
LETTER
https://www.readbyqxmd.com/read/30362271/response-to-the-letter-to-the-editor-for-embryo-fetal-development-studies-with-the-dietary-supplement-vinpocetine-in-the-rat-and-rabbit
#14
LETTER
Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
No abstract text is available yet for this article.
October 25, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30338937/a-population-based-case-control-study-of-the-association-between-weather-related-extreme-heat-events-and-orofacial-clefts
#15
Aida Soim, Scott C Sheridan, Syni-An Hwang, Wan-Hsiang Hsu, Sarah C Fisher, Gary M Shaw, Marcia L Feldkamp, Paul A Romitti, Jennita Reefhuis, Peter H Langlois, Marilyn L Browne, Shao Lin
BACKGROUND: Limited epidemiologic research exists on the association between weather-related extreme heat events (EHEs) and orofacial clefts (OFCs). We estimated the associations between maternal exposure to EHEs in the summer season and OFCs in offspring and investigated the potential modifying effect of body mass index on these associations. METHODS: We conducted a population-based case-control study among mothers who participated in the National Birth Defects Prevention Study for whom at least 1 day of their first two post-conception months occurred during summer...
October 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30338928/using-birth-defects-surveillance-programs-for-population-based-estimation-of-sibling-recurrence-risks
#16
EDITORIAL
A J Agopian, Jason L Salemi, Jean Paul Tanner, Russell S Kirby
No abstract text is available yet for this article.
October 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30325584/teratogenicity-of-valproic-acid-and-its-constitutional-isomer-amide-derivative-valnoctamide-in-mice
#17
Ying Linda Lin, Meir Bialer, Robert M Cabrera, Richard H Finnell, Bogdan J Wlodarczyk
OBJECTIVES: The anticonvulsant valproic acid (VPA) has a known teratogenic effect capable of inducing major congenital malformations and developmental disorders. A comparative teratogenicity study of VPA and its analog valnoctamide (VCD), which is a new generation candidate antiepileptic drug, was carried out using Swiss Vancouver (SWV) mice. METHODS: Pregnant SWV dams were treated with either a single intraperitoneal injection of VPA (1.8 and 2.7 mmol/kg), VCD (1...
October 16, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30239173/tissue-biomechanics-during-cranial-neural-tube-closure-measured-by-brillouin-microscopy-and-optical-coherence-tomography
#18
Jitao Zhang, Raksha Raghunathan, Justin Rippy, Chen Wu, Richard H Finnell, Kirill V Larin, Giuliano Scarcelli
BACKGROUND: Embryonic development involves the interplay of driving forces that shape the tissue and the mechanical resistance that the tissue offers in response. While increasing evidence has suggested the crucial role of physical mechanisms underlying embryo development, tissue biomechanics is not well understood because of the lack of techniques that can quantify the stiffness of tissue in situ with 3D high-resolution and in a noncontact manner. METHODS: We used two all-optical techniques, optical coherence tomography (OCT) and Brillouin microscopy, to map the longitudinal modulus of the tissue from mouse embryos in situ...
September 21, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30230717/descriptive-epidemiology-of-cerebellar-hypoplasia-in-the-national-birth-defects-prevention-study
#19
Meredith M Howley, Kim M Keppler-Noreuil, Christopher M Cunniff, Marilyn L Browne
BACKGROUND: Cerebellar hypoplasia is a rare disorder of cerebellar formation in which the cerebellum is not completely developed, smaller than it should be, or completely absent. The prevalence of cerebellar hypoplasia at birth is unknown, and little is known about epidemiological risk factors. Using data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study, we analyzed clinical features and potential risk factors for nonsyndromic cerebellar hypoplasia...
September 19, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/30230268/status-of-population-based-birth-defects-surveillance-programs-before-and-after-the-zika-public-health-response-in-the-united-states
#20
Marlene Anderka, Cara T Mai, Emily M Judson, Peter H Langlois, Philip J Lupo, Kimberlea Hauser, Jason L Salemi, Jane Correia, Mark A Canfield, Russell S Kirby
BACKGROUND: The 2016 Zika public health response in the United States highlighted the need for birth defect surveillance (BDS) programs to collect population-based data on birth defects potentially related to Zika as rapidly as possible through enhanced case ascertainment and reporting. The National Birth Defects Prevention Network (NBDPN) assessed BDS program activities in the United States before and after the Zika response. METHODS: The NBDPN surveyed 54 BDS programs regarding activities before and after the Zika response, lessons learned, and programmatic needs...
September 19, 2018: Birth Defects Research
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