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Acta Medica Lituanica

Virginija Šileikienė, Marius Urbonas, Mindaugas Matačiūnas, Jolita Norkūnienė
Objective: CT is able to precisely define the pathological process in COPD. There are a number of previous articles discussing the distribution of emphysema and its connection with pulmonary function tests. However, the results obtained by the researchers are not identical. Purpose: To assess relationships between emphysema and pulmonary function test parameters in COPD patients. Materials and methods: Fifty-nine patients diagnosed to have COPD underwent chest CT examinations and pulmonary function tests...
2017: Acta Medica Lituanica
Gabrielius Jakutis, Lina Ragelienė, Jelena Rascon
Introduction: Ewing sarcoma (ES) is a rare and aggressive malignant neoplasm that mostly affects children and adolescents. Recent studies reported a gap of 20% in childhood cancer survival rates between the Northern/Western and the Eastern European countries. We aimed to analyse the survival of patients treated for ES at our institution, to evaluate its correspondence to current survival rates in the expert centres, and to assess changes in treatment outcomes over time. Materials and methods: A retrospective single-centre study was performed...
2017: Acta Medica Lituanica
Nijolė Drazdienė, Mari Laan, Jolanta Zaikauskienė, Vytautas Usonis
Background: The study presents data on a sample of children under one year of age hospitalized with lower respiratory tract infections (LRTIs) in Lithuania and Estonia. Subjects and methods: This large, retrospective, cross-sectional, observational epidemiologic survey was conducted in 12 countries in Central and Eastern Europe. Eligible subjects were under one year of age, hospitalized for LRTIs, for whom RDT (Rapid Diagnostic Test) was performed. Physicians completed questionnaires at discharge or on the first check-up visit after hospitalization...
2017: Acta Medica Lituanica
Eglė Zlatkutė, Rasa Liutkevičienė, Alvita Vilkevičiūtė, Brigita Glebauskienė, Loresa Kriaučiūnienė, Silvija Jakštienė, Dalia Žaliūnienė
Background: The pathogenesis of pituitary adenoma (PA) is complex and poorly understood. It is thought that PA has a multifactorial aetiology; genetic factors also have an impact on PA development. Since MMP1 and FGFR4 genes play an important role in tumour growth, differentiation and progression, we decided to determine if the frequency of the genotypes of MMP-1 and FGFR4-R388 polymorphisms influence the development of PA. Materials and methods: The study enrolled n = 100 patients with PA and n = 200 healthy controls (reference group)...
2017: Acta Medica Lituanica
Narimantas E Samalavičius, Audrius Dulskas, Kęstutis Petrulis, Alfredas Kilius, Renatas Tikuišis, Raimundas Lunevičius
Completion total mesorectal excision (TME) is a rare but complex procedure after transanal endoscopic microsurgery for early rectal cancer with unfavourable final histology. Two cases are reported when completion TME was performed after upfront transanal partial mesorectal dissection. Intact non-perforated TME specimens with negative and adequate distal and circumferential margins were created. The quality of both total mesorectal excisions was complete and distal margins were sufficient. We believe that our technique might be a way of approaching completion TME after TEM, especially in cases of low rectal cancer...
2017: Acta Medica Lituanica
Jelena Volochovič, Diana Ramašauskaitė, Ramunė Šimkevičiūtė
Background: Invasive placenta is a rare obstetrical pathology that is life-threatening to mother and child. It is important to diagnose this pathology as early as possible and to plan further optimal care of patients in order to minimize life-threatening complications. The aim of this study was to analyze the frequency of cases of invasive placenta, the peculiarities of their clinical manifestation in women who gave birth from 2006 to 2015, to evaluate diagnostic and treatment options of this pathology, and to review their changes when the level of services provided by the institution changes...
2017: Acta Medica Lituanica
Agnė Dzingutė, Gaivilė Pileičikienė, Aušra Baltrušaitytė, Gediminas Skirbutis
Background: The aetiology of temporomandibular joint disorders (TMD) is multifactorial, whereas occlusal disharmony is one of the predisposing factors. Researchers still discuss the relation between occlusion and TMD. Objective: The study aims to investigate the relation between static occlusal parameters and TMD clinical symptoms using T-Scan II analysis system. Material and methods: The sample consisted of 44 persons divided into the treatment group of 20 TMD patients and the control group of 24 subjects without TMD...
2017: Acta Medica Lituanica
Justina Katinaitė, Birutė Petrauskienė
Background: Recurrence affects about 30% (20% to 50%) of patients within 18 months after the initial episode of acute pericarditis resulting in subsequent rehospitalizations. Bearing in mind high treatment costs of patients admitted to hospital with acute and recurrent pericarditis, there is a need to optimize the treatment of both of these conditions. Materials and methods: We present a case of recurrent pericarditis. The first episode of pericarditis was diagnosed in 2006...
2017: Acta Medica Lituanica
Gabrielius Jakutis, Ieva Norkienė, Donata Ringaitienė, Tomas Jovaiša
Background: Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on patient homeostasis. The aim of the study was to identify the determinants of supra-physiological values of partial oxygen pressure during on-pump cardiac surgery and to assess the impact of hyperoxia on clinical outcomes. Materials and methods: Retrospective data analysis of the institutional research database was performed to evaluate the effects of hyperoxia in patients undergoing elective cardiac surgery with cardiopulmonary bypass, 246 patients were included in the final analysis...
2017: Acta Medica Lituanica
Rūta Dubakienė, Vilija Rubinaitė, Malvina Petronytė, Indrė Dalgėdienė, Odilija Rudzevičienė, Dalia Dubakaitė, Palmira Rudalevičienė, Aurelija Žvirblienė
Background: Allergic diseases are the most prevalent chronic diseases in the developed countries. It is believed that early allergic sensitization and respiratory viral infections play an important role in the development of allergic diseases and asthma. Methods: The current study investigated the correlation between asthma, allergy, and various markers - allergen-specific IgE, IgG4 and IgA, ECP, IgM, and IgG antibodies against respiratory viruses hRSV and hPIV1-4 - in blood serum samples from 80 children (mean age 5...
2017: Acta medica Lituanica
Vaida Gedvilaitė, Diana Schveigert, Saulius Cicėnas
Lung cancer is the leading cause of cancer-associated deaths worldwide. Surgery is the standard treatment for early-stage non-small cell lung cancer (NSCLC). Advances in the knowledge of the biology of non-small cell lung cancer have revealed molecular information used for systemic cancer therapy targeting metastatic disease, with an important impact on patients' overall survival (OS) and quality of life. However, a biopsy of overt metastases is an invasive procedure limited to certain locations and not easily acceptable in the clinic...
2017: Acta medica Lituanica
Austėja Juškaitė, Indrė Tamulienė, Jelena Rascon
BACKGROUND: Neuroblastoma (NB) is the most common extracranial solid tumour in children. This is a very rare disease with heterogeneous biology varying from complete spontaneous regression to a highly aggressive tumour responsible for 15% of malignancy-related death in early childhood. Analyses of survival rates in Europe have shown a considerable difference between Northern/Western and Eastern European countries. Treatment results of NB in Lithuania have never been analyzed. AIM: To assess the survival rate of children with NB according to initial spread of the disease, age at diagnosis, the MYCN amplification, risk group, and treatment period...
2017: Acta Medica Lituanica
Jūratė Gudaitytė, Dominykas Dvylys, Indrė Šimeliūnaitė
THE OBJECTIVE: The aim is to present the major effects of cancer treatment (chemotherapy, radiotherapy, surgery) that the anaesthesiologist should consider preoperatively, and to review techniques of the analgesic management of the disease. MATERIALS AND METHODS: To summarize the major challenges that cancer patients present for the anaesthesiologists, a literature review was conducted. Articles presenting evidence or reviewing the possible effects of anaesthetics on cancer cells were also included...
2017: Acta medica Lituanica
Odeta Bobelytė, Ieva Gailiūtė, Vytautas Zubka, Virginija Žilinskaitė
Research was carried out at the paediatric intensive care unit (paediatric ICU) of the Children's Hospital, affiliate of Vilnius University Hospital Santariškių klinikos. BACKGROUND: Being the most common cause of children's death, sepsis is a challenge for most physicians. In order to improve the outcomes, it is important to know the aetiology and peculiarities of sepsis in a particular region and hospital. The aim of this study was to analyse the outcomes of sepsis in a paediatric intensive care unit and their relation with patients' characteristics and causative microorganisms...
2017: Acta Medica Lituanica
Jolanta Dadonienė, Gintarė Kumžaitė, Rimvydė Mačiulytė, Dalia Miltinienė
OBJECTIVE: The goal of this study was to describe long-term patient survival and possible prognostic factors of a group of patients diagnosed with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) hospitalized at the tertiary Rheumatology Centre in Vilnius. MATERIAL AND METHODS: A cross-sectional study of 27 patients hospitalized at the Rheumatology Centre of Santaros klinikos of Vilnius University Hospital from 1 January 2001 to 31 December 2015 with diagnoses of GPA and MPA were carried out...
2017: Acta Medica Lituanica
Raimonda Piškinienė, Mantas Banevičius
The aim of the study was to analyse the rate of complications of orbital endoimplantation in patients operated from 2002 to 2014 at the Eye Clinic of the Lithuanian University of Health Sciences and to compare it with the results in the literature. Enucleation must be performed very carefully in order to prevent any additional trauma, infection, deformation, and to create an optimal conjunctival socket. However, complications occur despite efforts and qualified surgeons. The most common complications described in the literature are thinning and cysts of the conjunctiva, a foreign body reaction, secretion, symblepharons, fornix deficiency, ptosis, permanent pain, dislocation, migration and protrusion of the implant, a primary or secondary infection, and implant extrusion...
2017: Acta Medica Lituanica
Aistė Kadziauskienė, Ernesta Strelkauskaitė, Eglė Mockevičiūtė, Rimvydas Ašoklis, Eugenijus Lesinskas, Leopold Schmetterer
CONFLICT OF INTEREST: None of the authors have any conflict of interest to declare, financial or otherwise. No financial or other support was received for the study. BACKGROUND: The aim of the study was to assess changes in macular thickness after trabeculectomy in respect to the use of 5-fluorouracil (5-FU) as well as to analyse possible associations between the postoperative changes in macular thickness and intraocular pressure (IOP). MATERIALS AND METHODS: The prospective observational study included 106 eyes (100 patients) with glaucoma who underwent trabeculectomy with or without 5-FU...
2017: Acta Medica Lituanica
Rasa Čiumbaraitė, Rasa Liutkevičienė
BACKGROUND: The purpose of our study was to assess the distribution and patterns of refractive errors in children for the proper planning of paediatric eye care at the centre. MATERIAL AND METHODS: The study was conducted in the hospital of the Lithuanian University of Health Sciences in Kaunas, from 1 January 2012 to 31 December 2012. During this period, a total of 11,406 children, aged 0-18 years, were evaluated at the outpatient department of paediatric ophthalmology, Kauno klinikos, the Lithuanian University of Health Sciences...
2017: Acta Medica Lituanica
Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė, Loresa Kriaučiūnienė, Paulina Vaitkienė, Romanas Chaleckis, Vytenis Pranas Deltuva
BACKGROUND: Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls...
2017: Acta medica Lituanica
Meda Sutkevičiūtė, Monika Stančiukaitė, Giedrė Bulotienė
Patients with oncological diseases, especially palliative care patients, suffer from physical and psychological difficulties. The quality of life of such patients is bad, they do not have purpose to live and they feel anxiety and distress. In 1959 Victor Frankl wrote the book Man's Search for Meaning in which he stated that the driving force of human life lay in the ability to discern the meaning of faith and spirituality. Inspired by Frankl's ideas, the American psychiatrist William Breitbart with colleagues have developed both an individual and group model of Meaning-Centered Psychotherapy...
2017: Acta Medica Lituanica
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