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Journal of Medical Biochemistry

Snežana Jovičić, Nada Majkić-Singh
Medical biochemistry is the usual name for clinical biochemistry or clinical chemistry in Serbia, and medical biochemist is the official name for the clinical chemist (or clinical biochemist). This is the largest sub-discipline of the laboratory medicine in Serbia. It includes all aspects of clinical chemistry, and also laboratory hematology with coagulation, immunology, etc. Medical biochemistry laboratories in Serbia and medical biochemists as a profession are part of Health Care System and their activities are regulated through: the Health Care Law and rules issued by the Chamber of Medical Biochemists of Serbia...
April 2017: Journal of Medical Biochemistry
Srdjan Mijatović, Tamara Alempijević, Branislava Stefanović, Vasilije Jeremić, Slobodan Krstić, Nikola Radmanović, Sanja Jovanović, Branislav Stefanović
BACKGROUND: Oxidative stress represents tissue damage caused by reactive forms of oxygen and nitrogen due to the inability of antioxidant mechanisms to reduce reactive forms into more stable ones. The aim of the study was to evaluate the influence of surgical trauma on nitric oxide (NO) and nitrotyrosine (NT) values in patients undergoing conventional and laparoscopic cholecystectomy. METHODS: A prospective study included sixty patients from the Department of Emergency Surgery, Clinical Centre of Serbia who were operated for gallstone related chronic cholecystitis...
April 2017: Journal of Medical Biochemistry
Lidija Tulić, Snežana Vidaković, Ivan Tulić, Marijana Ćurčić, Jelena Stojnić, Katarina Jeremić
BACKGROUND: Our aim was to study the effect of GnRH agonist and antagonist protocols of ovarian stimulation on oxidative stress parameters in serum and the influence of oxidative stress parameters change on the outcome of IVF cycles. METHODS: This prospective study included 82 patients who underwent IVF procedures. We determined SOD, MDA and SH groups in serum. Serum samples were obtained between the second and fourth day of the cycle and on the day of HCG administration during ovarian stimulation...
April 2017: Journal of Medical Biochemistry
Velibor Čabarkapa, Branislava Ilinčić, Mirjana Đerić, Isidora Radosavkić, Mirko Šipovac, Jan Sudji, Veljko Petrović
BACKGROUND: Chronic kidney disease (CKD) is one of the most significant global health problems accompanied by numerous complicatons, with constant increase in the number of affected people. This number is much higher in early phases of disease and patients are mostly asymptomatic, so early detection of CKD is crucial. The aim was examination of the prevalence of CKD in the general population of males in Vojvodina, based on estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR), and exploring the determinants and awareness of CKD...
April 2017: Journal of Medical Biochemistry
Mirsad Panjeta, Ismet Tahirović, Emin Sofić, Jozo Ćorić, Amela Dervišević
BACKGROUND: The production of erythrocytes is regulated by the hormone erythropoietin (EPO), which maintains the blood haemoglobin (Hb) levels constant under normal conditions. Human EPO is a glycoprotein hormone and its synthesis is controlled by the hypoxia-inducible transcription factor. The aim of this study was to establish EPO and Hb levels in patients with chronic kidney disease (CKD), as well as in control subjects, and to investigate the relationship between these parameters...
April 2017: Journal of Medical Biochemistry
Bosa Mirjanic-Azaric, Sanja Avram, Tanja Stojakovic-Jelisavac, Darja Stojanovic, Mira Petkovic, Natasa Bogavac-Stanojevic, Svetlana Ignjatovic, Marina Stojanov
BACKGROUND: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. METHODS: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals...
April 2017: Journal of Medical Biochemistry
Milena S Pandrc, Anđelka Ristić, Vanja Kostovski, Marko Stanković, Vladimir Antić, Jelena Milin-Lazović, Jasmina Ćirić
BACKGROUND: Subclinical hypothyroidism (SCH) is defined as high TSH and normal thyroxine. Data on the effects of early substitution by levothyroxine on psychophysical health in SCH are still not consistent enough to support its introduction. METHODS: Clinical parameters, biochemical data and quality of life (Short Form 36 questionnaire) were measured before the intervention and 3 months after the euthyroid state had been achieved in SCH patients. RESULTS: Significant reduction in body weight (p=0...
April 2017: Journal of Medical Biochemistry
Ayfer Çolak, Celalettin Yılmaz, Burak Toprak, Serir Aktoğu
BACKGROUND: Serum procalcitonin (PCT) and C-reactive protein (CRP) are markers of systemic inflammation and bacterial infection. We aimed to compare the usefulness of procalcitonin and CRP in patients with community-acquired pneumonia and exacerbations of chronic obstructive pulmonary disease (COPD). METHODS: A total of 116 consecutive patients were included in the study: 76 with chronic obstructive pulmonary disease in group 1, and 40 with pneumonia in group 2...
April 2017: Journal of Medical Biochemistry
Cristiano Ialongo, Alessia Francesca Mozzi, Sergio Bernardini
BACKGROUND: Busulfan (Bu) requires therapeutic drug monitoring (TDM) in subjects undergoing a conditioning regimen for hematopoietic stem cell transplantation (HSCT). To speed up the procedure and increase reproducibility, we improved our routine LC-MS/MS assay using the on-line solid-phase extraction (SPE) of samples. METHODS: A protein precipitation (PP) step was performed before the on-line SPE of Bu from 200 µL of plasma spiked with octa-deuterated Bu (D8-Bu) as the internal standard...
April 2017: Journal of Medical Biochemistry
Giuseppe Lippi, Laura Chiozza, Camilla Mattiuzzi, Mario Plebani
Patient and sample misidentification may cause significant harm or discomfort to the patients, especially when incorrect data is used for performing specific healthcare activities. It is hence obvious that efficient and quality care can only start from accurate patient identification. There are many opportunities for misidentification in healthcare and laboratory medicine, including homonymy, incorrect patient registration, reliance on wrong patient data, mistakes in order entry, collection of biological specimens from wrong patients, inappropriate sample labeling and inaccurate entry or erroneous transmission of test results through the laboratory information system...
April 2017: Journal of Medical Biochemistry
Muhittin A Serdar, Başar Batu Can, Meltem Kilercik, Zeynep A Durer, Fehime Benli Aksungar, Mustafa Serteser, Abdurrahman Coskun, Aysel Ozpinar, Ibrahim Unsal
BACKGROUND: 25 (OH) vitamin D3 (25(OH)D) and parathyroid hormone (PTH) are important regulators of calcium homeostasis. The aim of this study was to retrospectively determine the cut-off for sufficient 25(OH)D in a four-season region and the influence of age, seasons, and gender on serum 25(OH)D and PTH levels. METHODS: Laboratory results of 9890 female and 2723 male individuals aged 38.8±22.1 years who had simultaneous measurements of 25(OH)D and PTH were retrospectively analyzed by statistical softwares...
January 2017: Journal of Medical Biochemistry
Zeynep B Gungor, Nurver Sipahioglu, Huseyin Sonmez, Hakan Ekmekci, Sait Toprak, Gulsel Ayaz, Cigdem Bayram Gurel, Tugba Mutlu, Turgut Ulutin, Fikret Sipahioglu, Baris Ilerigelen
BACKGROUND: Cardiovascular diseases (CVD) account for approximately 50% of the total deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease. Predictive value of endothelial dysfunction markers related with the earliest stage of atherosclerosis has been getting more attention. We hypothesized that differences in endothelial dysfunction biochemical markers among genders would aid to capture proatherogenic activity that was not diagnosed by conventional risk assessment scoring systems...
January 2017: Journal of Medical Biochemistry
Zubeyde Erbayraktar, Ahmet Turan Evlice, Gokhan Yilmaz, Canan Yazici, Gorsev Yener, Nuriye Nuray Ulusu
BACKGROUND: Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric patients with dementia have rarely been reported. In this study, we aimed to disclose the importance of associated renal changes for the pathogenesis of AD. METHODS: Patients with AD (n=107) and geriatric patients with dementia and without dementia (n=124) (231 patients in total) from Dokuz Eylul and Cukurova University Hospitals were enrolled in the study...
January 2017: Journal of Medical Biochemistry
Ljiljana Milić, Ilijana Grigorov, Slobodan Krstić, Miljan S Ćeranić, Bojan Jovanović, Jelena Stevanović, Predrag Peško
BACKGROUND: Intra-abdominal infection in secondary peritonitis drives as excessive production of inflammatory mediators and the development of systemic inflammatory response syndrome (SIRS) or sepsis. Finding a specific marker to distinguish SIRS from sepsis would be of immense clinical importance for the therapeutic approach. It is assumed that high-mobility group box 1 protein (HMGB1) could be such a marker. In this study, we examined the time course changes in the blood levels of HMGB1, C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) in patients with secondary peritonitis who developed SIRS or sepsis...
January 2017: Journal of Medical Biochemistry
Gabriel Lima-Oliveira, Gian Cesare Guidi, Andre Valpassos Pacifici Guimaraes, Jose Abol Correa, Giuseppe Lippi
BACKGROUND: The multifaceted clinical laboratory process is divided in three essential phases: the preanalytical, analytical and postanalytical phase. Problems emerging from the preanalytical phase are responsible for more than 60% of laboratory errors. This report is aimed at highlighting and discussing nonconformity (e.g., nonstandardized procedures) in primary blood tube mixing immediately after blood collection by venipuncture with evacuated tube systems. METHODS: From January 2015 to December 2015, fifty different laboratory quality managers from Brazil were contacted to request their internal audit reports on nonconformity regarding primary blood tube mixing immediately after blood collection by venipuncture performed using evacuated tube systems...
January 2017: Journal of Medical Biochemistry
Gianni Turcato, Gianfranco Cervellin, Gian Luca Salvagno, Eleonora Zaccaria, Giuseppe Bartucci, Marco David, Antonio Bonora, Massimo Zannoni, Giorgio Ricci, Giuseppe Lippi
BACKGROUND: Universally accepted and validated instruments for predicting the outcome of patients presenting to the emergency department (ED) with severe dyspnoea do not exist so far, nor are they regularly used by the emergency physicians. This study hence aimed to establish whether red blood cell distribution width (RDW) may be a predictive parameter of 1-year mortality in a population of patients admitted to the ED with severe dyspnoea attributable to different underlying disorders...
January 2017: Journal of Medical Biochemistry
Danijela Ristovski-Kornic, Aleksandra Stefanović, Jelena Kotur-Stevuljević, Aleksandra Zeljković, Vesna Spasojević-Kalimanovska, Jelena Vekić, Milica Miljković, Dušan Paripović, Amira Peco-Antić, Zorana Jelić-Ivanović
BACKGROUND: The aim of this study was to explore oxidative stress status, especially the enzyme myeloperoxidase in children with end-stage renal disease. Also, we investigated possible associations between the atherogenic index of plasma and these parameters. METHODS: Lipid status parameters, oxidative stress status parameters, and myeloperoxidase concentration were measured in the sera of 20 children in the last stage of chronic renal disease (ESRD) and 35 healthy children of matching age and sex...
January 2017: Journal of Medical Biochemistry
Suat Terzi, Engin Dursun, Adnan Yılmaz, Zerrin Özergin Coşkun, Abdulkadir Özgür, Metin Çeliker, Münir Demirci
BACKGROUND: Bell's palsy (BP) is the most common acute mononeuropathy of unilateral facial paralysis. Immune, infective and ischaemic mechanisms are potential contributors to the development of BP, but the precise cause remains unclear. Recently, oxidative stress has been proposed as a risk factor of various idiopathic diseases. The aim of this study was to investigate the possible role of oxidative stress in patients with BP. METHODS: Thirty-two patients with BP and 30 healthy controls were included in this study...
January 2017: Journal of Medical Biochemistry
Aydın Kahraman, Emre Mutlu, Mustafa Aldağ
BACKGROUND: In this study, the effects of olmesartan therapy on asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), L-arginine and inducible nitric oxide synthase (iNOS) levels were investigated in patients undergoing cardiopulmonary bypass. METHODS: Patients were randomly allocated to two groups, control and olmesartan. Olmesartan was administered 30 mg once a day beginning from preoperative day 5 to postoperative day 28 and on operation day...
January 2017: Journal of Medical Biochemistry
Aleksandra Catić-Đorđević, Tatjana Cvetković, Nikola Stefanović, Radmila Veličković-Radovanović
Immunosuppressive drugs play a crucial role in the inhibition of immune reaction and prevention of graft rejection aswell as in the pharmacotherapy of autoimmune disorders. Effective immunosuppression should provide an adequate safety profile and improve treatment outcomes and the patients' quality of life. High-risk transplant recipients may be identified, but a definitive prediction model has still not been recognized. Therapeutic drug monitoring (TDM) for immunosuppressive drugs is an essential, but at the same time insufficient tool due to low predictability of drug exposition and marked pharmacokinetic variability...
January 2017: Journal of Medical Biochemistry
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