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Open Medicine (Warsaw, Poland)

Wioletta Medrzycka-Dabrowska, Katarzyna Lewandowska, Katarzyna Kwiecień-Jaguś, Katarzyna Czyż-Szypenbajl
Background: Sleep disturbances in intensive care unit (ICU) patients have been studied worldwide for over 30 years. Factors contributing to sleep disturbances are still being identified, and therapeutic procedures aimed at the mitigation of such ailments are consequently being developed. Objectives: The aim of this study was to review the literature on sleep disturbances in intensive care unit patients. Material and Methods: MEDLINE PubMed, OVID, Web of Science, and EBSCO databases have been searched using adequate keywords...
2018: Open Medicine (Warsaw, Poland)
Ismail Yaqub Maolood, Yahya Eneid Abdulridha Al-Salhi, Songfeng Lu
In this study, an effective means for detecting cancer region through different types of medical image segmentation are presented and explained. We proposed a new method for cancer segmentation on the basis of fuzzy entropy with a level set (FELs) thresholding. The proposed method was successfully utilized to segment cancer images and then efficiently performed the segmentation of test ultrasound image, brain MRI, and dermoscopy image compared with algorithms proposed in previous studies. Results showed an excellent performance of the proposed method in detecting cancer image segmentation in terms of accuracy, precision, specificity, and sensitivity measures...
2018: Open Medicine (Warsaw, Poland)
Liang Chen, Jun Zhang, Guoshi Pan, Xia Li, Tianwu Shi, Wensheng He
Background: Cuffed and uncuffed endotracheal tubes are commonly used for pediatric patients in surgery and emergency situations. It is still controversial which approach should be adopted. The purpose of the study was to compare the application of cuffed and uncuffed endotracheal tubes in pediatric patients. Methods: We searched PubMed, Web of Science and Cochrane Library for clinical trials, which compared the two applications in children. The study characteristics and clinical data were summarized by two independent reviewers...
2018: Open Medicine (Warsaw, Poland)
Wang Hai-Long, Pang Xiao-Hua, Yang Jian-Jun
The efficacy and safety of enoxaparin (ENOX) in percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) remains unaddressed. The primary endpoint evaluated was myocardial infarction (MI) or death. The secondary endpoint was defined as major bleeding complications. Studies comparing the differences in the efficacy and safety of ENOX versus unfractionated heparin (UFH) in PCI for the treatment of STEMI were evaluated. We presented the odds ratios for individual studies and performed heterogeneity, quality assessment, and publication bias analysis...
2018: Open Medicine (Warsaw, Poland)
Ijeoma A Meka, Obumneme B Anyim, Joseph T Enebe, Kingsley N Ukwaja, Martin C Ugonabo
Background: Dyslipidaemia and hypertension are established major risk factors for cardiovascular diseases. The suggested roles of miRNA-122 and ADAM17 in lipid metabolism can therefore be applied in the management of metabolic disorders. The authors' aim was to determine the association between miRNA-122 and ADAM17, as well as the association between miRNA-122 and lipid fractions, in the study participants. Method: A comparative cross-sectional study was conducted among 200 hypertensive patients and 100 non-hypertensive adult controls between May, 2015, and June, 2016, in Nigeria...
2018: Open Medicine (Warsaw, Poland)
Lu Xiaoling, Tang Tingyu, Hu Caibao, Zhao Tian, Chen Changqin
Objective: The aim of this study was to investigate the diagnostic performance of serum 1,3-β-D-gluan as biomarker for invasive fungal infection through meta-analysis. Methods: The electronic databases of Medline, Cochrane, Embase, Web of Science, OVID and CNKI were systematic searched to identified the case-control or Cohort studies relevant to diagnostic efficacy of serum 1,3-β-D-glucan for invasive fungal infection. The data of true positive (tp), false positive (fp), false negative (fn) and true negative (tn) patients number were extracted from each of the original included studies...
2018: Open Medicine (Warsaw, Poland)
Jozef Kováč, Monika Vítězová, Ivan Kushkevych
Sulfate-reducing bacteria (SRB) are anaerobic microorganisms, which use sulfate as an electron acceptor in the process of dissimilatory sulfate reduction. The final metabolic product of these anaerobic microorganisms is hydrogen sulfide, which is known as toxic and can lead to damage to epithelial cells of the large intestine at high concentrations. Different genera of SRB are detected in the large intestine of healthy human and animals, and with diseases like Crohn's disease and ulcerative colitis. SRB isolated from rodents with ulcerative colitis have produced 1...
2018: Open Medicine (Warsaw, Poland)
Shichao Liu, Tongbin Ding, Hang Liu, Liguo Jian
Objective: To explore the relationship between G protein-coupled estrogen receptor (GPER) and hypertension in post-menopausal women. Methods: Using a matched case-control design, clinical and laboratory data were collected. Conditional logistic regression with stratified analysis was conducted to identify the association between GPER and hypertension. Results: The GPER level was significantly lower in the case group than in the control group (126...
2018: Open Medicine (Warsaw, Poland)
Paola Bin, Adelaide Conti, Emanuele Capasso, Piergiorgio Fedeli, Pierdomenico Ceccarelli, Fabio Policino, Claudia Casella, Paola Delbon
Responsibility means responding to the damaging consequences of technical work and in this binding perspective the general principles of guilt in genetic diagnostics and related activities are not different from any other medical performance. Performing a genetic test however, especially when it has predictive characteristics, offers absolutely peculiar technical deontological issues. It is not and should not be considered as a mere habitual laboratory test but as a complex set of interactions that presupposes adequate information as a valid consensus to formalize absolutely in written form...
2018: Open Medicine (Warsaw, Poland)
Paola Bin, Emanuele Capasso, Mariano Paternoster, Piergiorgio Fedeli, Fabio Policino, Claudia Casella, Adelaide Conti
The risk-delimiting tools available to insurance companies are therefore substantial and it is also possible to argue that a margin of uncertainty is a natural component of the insurance contract. Despite this, businesses look at the potential of predictive medicine, and in particular the growing understanding of genetic mechanisms that support many common diseases. In particular, the rapid development of genetics has led many insurance companies to glimpse in the predictive diagnosis of disease by genetic testing the possibility of extending the calculation of the individual risk of developing a particular disease to appropriate premiums or even denying insurance coverage...
2018: Open Medicine (Warsaw, Poland)
Nuran Katgi, Mehmet Unlu, Pinar Cimen, Emre Oner, Bilkay Serez, Derya Giakoup
In rare cases, pseudomesotheliomatous tumors spread diffusely within the pleura to form an encasing mass, which may be confused with diffuse malignant mesothelioma (DMM). A 73-year-old male presented with chest pain, dyspnea and a significant loss of weight and appetite. His radiological and clinical features suggested DMM. However, immunohistochemical studies revealed a primary squamous cell cancer of the lung. To the best of our knowledge, this is the first case report of pseudomesotheliomatous primary squamous cell lung cancer in Turkey, and also the seventh case worldwide...
2018: Open Medicine (Warsaw, Poland)
Hernando Vargas-Uricoechea, Manuel Felipe Cáceres-Acosta
High blood pressure in patients with diabetes mellitus results in a significant increase in the risk of cardiovascular events and mortality. The current evidence regarding the impact of intervention on blood pressure levels (in accordance with a specific threshold) is not particularly robust. Blood pressure control is more difficult to achieve in patients with diabetes than in non-diabetic patients, and requires using combination therapy in most patients. Different management guidelines recommend initiating pharmacological therapy with values >140/90 mm/Hg; however, an optimal cut point for this population has not been established...
2018: Open Medicine (Warsaw, Poland)
Ryoji Iida, Mayu Aono, Jonathan Choy
This study is a case report, which presents a case of severe mitral regurgitation in a 77-year-old man. Two-dimensional transesophageal echocardiography (TEE), regurgitant jets directed anteriorly in early systole and centrally to laterally in late systole were seen, while three-dimensional TEE showed a flail posterior middle scallop not only angulated centrally, but also laterally, which provided insight into the mechanism of mitral regurgitant jet direction. This case demonstrates the clinical usefulness of 3-dimensional TEE for identifying the mechanism of mitral regurgitant jets...
2018: Open Medicine (Warsaw, Poland)
Krzysztof Celejewski, Ryszard Pogorzelski, Sadegh Toutounchi, Ewa Krajewska, Tomasz Wołoszko, Małgorzata Szostek, Wawrzyniec Jakuczun, Patryk Fiszer, Małgorzata Legocka, Zbigniew Gałązka
Introduction: Incidentaloma is defined as an tumor diagnosed accidentally using imaging studies performed due to other indications. The aim of this paper was to describe the diagnostic and treatment problems experienced by patients with adrenal incidentaloma in a clinical practice. Material and methods: In years 2009-2012 there were 33(16,5%) adrenal tumors diagnosed incidentally out of 200 cases treated due to adrenal pathology. The group consisted of 54 patients aged 27-77...
2018: Open Medicine (Warsaw, Poland)
Chai Hong Rim, Chang Won Lee, Young Soo Heo, Rinet Aieng, Sung Yeon Jun, Sung Hun Choi, Jae Suk Rim
This study was conducted to provide practical information for actual preparation of medical volunteering in tropical Asia, mainly the distribution of common illnesses encountered during mission. From 2012 to 2017, we visited two rural areas of Eastern Cambodia for medical volunteering missions, Cham Lak and Khsoem. Neither area has electricity or public water. We classified the common cases encountered during missions into six groups (upper respiratory infection, gastroenteritis, vaginitis and/or cystitis, dermatitis, work-related pain and parasite prevention) and assessed the distribution...
2018: Open Medicine (Warsaw, Poland)
Xuefei Zhang, Mo Li, Desheng Lv, Ge Sun, Yu Bai, Hui Tian, Changhong Liu
BRAF mutations are known as oncogenic drivers of non-small cell lung cancer (NSCLC). BRAF inhibition has demonstrated anti-tumor activity in patients with BRAF V600E mutant NSCLC. Further molecular screening for novel BRAF thr599dup mutation is warranted. The novel BRAF Thr599dup gene mutation, for which the repeat amino acid-tyrosine is inserted between the 599th amino acid and the 600th amino acid in exon 15 of BRAF, was identified by next-generation sequencing (NGS) during routine clinical care in a lung carcinoma sample from an Asian never-smoker...
2018: Open Medicine (Warsaw, Poland)
Lu Peihua, Wang Jianqin
OBJECTIVE: To evaluate the clinical effects of piribedil in adjuvant treatment of Parkinson's Disease (PD) by pooling previously openly published studies. METHODS: The related electronic databases of Medline (1960~2017.5), Cochrane central register of controlled trials (CENTRAL), EMBASE (1980~2017.5) and Wanfang (1986~20175.5) were searched by two reviewers (Lu Peihua and Wang Jianqian) independently for publications including the topic of prospective randomized controlled trials about clinical effects of piribedil in adjuvant treatment of PD...
2018: Open Medicine (Warsaw, Poland)
János Bencze, Krisztina Pocsai, Balázs Murnyák, Péter Attila Gergely, Béla Juhász, Zoltán Szilvássy, Tibor Hortobágyi
Melanin-concentrating hormone (MCH) is a cyclic 19 amino acid orexigenic hypothalamic peptide. MCH is located in the lateral and dorsal hypothalamus, as well as in the zona incerta. In mammals MCH increases food intake, contributes to regulation of energy balance, temperature, reproductive function, endocrine homeostasis and biological rhythms. Several studies have proved the significance of MCH in obesity, diabetes and depression. Although the peptide is well-characterized in mouse models, much less is known about its functions in avians...
2018: Open Medicine (Warsaw, Poland)
Brenda K Wiederhold, Pietro Cipresso, Daniele Pizzioli, Mark Wiederhold, Giuseppe Riva
Burnout is an important problem for physicians, with a strong impact on their quality of life and a corresponding decrease in the quality of care with an evident economical burden for the healthcare system. However, the range of interventions used to decrease this problem could be very fragmented and with the aim to shed some light on this issue, this study reviews and summarizes the currently available studies. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to identify studies about intervention on physician burnout...
2018: Open Medicine (Warsaw, Poland)
Paola Bin, Adelaide Conti, Emanuele Capasso, Piergiorgio Fedeli, Fabio Policino, Claudia Casella, Paola Delbon, Vincenzo Graziano
The aim of this article is to provide an analysis of the main issues related to the application of predictive medicine by analysing the most significant ethical implications. Genetic medicine is indeed a multidisciplinary matter that covers broad contexts, sometimes transversely. Its extreme complexity, coupled with possible perceived repercussions on an individual's life, involves important issues in the ethical, deontological and legal medical field. The aspects related to the execution of genetic testing have to be addressed at different levels, starting with the correct information about the "cognitive" meaning they intend (by forcefully disassociating it from the strange "preventive aspect") to the legal medical issues that can be aroused in the field of forensic pathology, medical responsibility and insurance...
2018: Open Medicine (Warsaw, Poland)
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