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Open Medicine (Warsaw, Poland)

Fangwei Liu, Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Shimin Xiong, Chengliang Xiong, Yuanzhong Zhou
Background Both sex hormone-binding globulin and central obesity have been found to be associated with metabolic and cardiovascular diseases. However, the direct relation between sex hormone-binding globulin and central obesity has not been demonstrated. Methodology We performed a cross-sectional study of 1166 male participants from Zunyi, Guizhou, western China, in 2013. Each participant completed a questionnaire and had a brief clinical exam with a fasting blood sample taken. All blood samples underwent standard laboratory testing for sex hormone-binding globulin...
2018: Open Medicine (Warsaw, Poland)
Xianguang Meng, Liyun Qiu, Haiyan Song, Ningning Dang
Objective: To investigate the effect of mitogen-activated protein kinase (MAPK) signaling pathway in epidermal terminal differentiation. Methods: The MAPK pathways (p38, ERK1/2, JNK) were inhibited by SB203580, PD98059, and SP600125 in normal human epidermal keratinocytes (NHEKs), respectively. Western blotting assays were performed to detect expression of filaggrin and differentiation-related proteins. The mRNA expressions of differentiation-related proteins were detected by real-time quantitative PCR (qRT-PCR)...
2018: Open Medicine (Warsaw, Poland)
Lei Sun, Yanli Zhang, Chao Zhang
Gastric cancer has high malignancy and early metastasis, which lead to poor survival rate. In this study, we assessed the expressions and prognostic values of MS4A family, a newly recently discovered family, by two online dataset, GEPIA and Kaplan Meier-plotter. From these results eight members, MS4A2, MS4A6, MS4A7, MS4A8, MS4A14, MS4A15, TMEM176A and TMEM176B showed positive expression in gastric cancer or normal tissues, and these genes were screened for further analysis of prognostic values. We observed that low mRNA expressions of MS4A2, MS4A7, MS4A14, MS4A15, TMEM176A and TMEM176B were correlated with better overall survival (OS) in all gastric cancer patients, while high mRNA expression of MS4A6 was observed to be associated with good prognosis...
2018: Open Medicine (Warsaw, Poland)
Hui-Juan Wang, Lei-Zhi Shi, Cun-Fei Liu, Shi-Min Liu, Song-Tao Shi
Objective: To investigate the relationship between uric acid and metabolic syndrome (MetS) in elderly women. Methods: A total of 468 women aged ≥60 years participating in a health examination were enrolled. The association between uric acid and MetS and its individual variables was evaluated by univariate and multivariate logistic regression models. Results: A dose-response relationship was observed for the prevalence of MetS and uric acid quartiles...
2018: Open Medicine (Warsaw, Poland)
Han Yanqing, Dong Cheng, Xu Ling
The purpose of this meta-analysis was to investigate the serum CA72-4 as a biomarker in the diagnosis of colorectal cancer by pooling the open published data. METHODS: An electronic search of databases Pubmed, Medline, Web of Science, Cochrane Embase CBM, and CNKI were performed by two reviewers (Han Yanqing, Dong Cheng) independently to identify the studies relevant to serum CA72-4 as a biomarker in the diagnosis of colorectal cancer. The patient number of true positive(tp), false positive(fp), false negative(fn) and true negative(tn) were extracted from each included study...
2018: Open Medicine (Warsaw, Poland)
Ti-Yuan Yang, Tao-Yeuan Wang, Marcelo Chen, Fang-Ju Sun, Allen W Chiu, Yu-Hsin Chen
Penile calciphylaxis is a rare cause of penile gangrene that presents in patients with end-stage renal disease. The rates of comorbidity and mortality of penile calciphylaxis are extremely high. Unlike other penile gangrene, such as Fournier's gangrene, the benefit of aggressive surgical therapy is controversial. Here we present a case of penile calciphylaxis in a 43-year-old man with end-stage renal disease on hemodialysis. He received total penectomy but died due to multisystem complications 2 weeks after surgery...
2018: Open Medicine (Warsaw, Poland)
Franz J Wiedermann, Kathrin Watzinger, Martina Stichlberger, Michael Joannidis, Christian Kaehler, Wolfgang Lederer
Arginine vasopressin can bind to high-affinity vasopressin V1a receptors in human leukocytes. This study aims to investigate the effects of arginine vasopressin on migration and chemotaxis of neutrophils and oxygen free radical release by human leukocytes. Neutrophils and monocytes were obtained from peripheral blood samples of ten healthy volunteers. Leukocyte migration was microscopically assessed in a modified 48-blind well microchemotaxis chamber, and respiratory burst activity was estimated using 2',7'-dichlorofluorescin diacetate in descending concentrations of arginine vasopressin...
2018: Open Medicine (Warsaw, Poland)
Xun Yu, Lemeng Zhang, Jianhua Chen
This study investigated the clinical efficacy, safety and tolerance of endostatin combined with gemcitabine and carboplatin for patients with advanced nonsmall cell lung cancer (NSCLC). From January 2010 to January 2014, 49 patients with advanced NSCLC were retrospectively evaluated; we defined 2 subgroups: a combination group (chemotherapy + anti-angiogenic therapy) and a chemotherapy group (chemotherapy only). The cases in the chemotherapy group received treatment with gemcitabine and carboplatin only, whereas the cases in the combination group received endostatin in combination with gemcitabine and carboplatin...
2018: Open Medicine (Warsaw, Poland)
Pierpaolo Di Lorenzo, Claudia Casella, Emanuele Capasso, Adelaide Conti, Piergiorgio Fedeli, Fabio Policino, Massimo Niola
The increase in the number of people who choose to have medical procedures done to improve their appearance may be due to changed social and cultural factors in modern society, as well to the ease of access and affordable costs of these cosmetic treatments. Today, two elements legitimate recourse to this type of treatment: the broad definition of health accepted by the law and the scientific community, and the provision of meticulous information to the entitled party previous to obtaining his or her consent...
2018: Open Medicine (Warsaw, Poland)
Adelaide Conti, Paola Bin, Claudia Casella, Emanuele Capasso, Piergiorgio Fedeli, Francesco Antonio Salzano, Lucia Terracciano, Mauro Piras
Non-therapeutic body modification interventions are permitted within the limits of the use of one's own body that can be specified in the legal system. The authors take into consideration Italian regulation on tattooing and piercing, in particular in relation to adolescents. Results: In Italy, several regions have therefore issued acts aimed at regulating the activities of tattoo and piercing also in reference to minors. Discussion. With regard to minors, the rules taken into account set precise limits in relation to the age criterion and subordinate the implementation of such practices to the provision of consent by legal representatives...
2018: Open Medicine (Warsaw, Poland)
Meng Qi, Ming Ye, Meng Li, Peng Zhang
Internal carotid artery (ICA) supraclinoid segment aneurysms extending into the sellar region and leading to pituitary dysfunction are a rare occurrence. To date, long-term follow up of pituitary function 2 years post-treatment has never been reported. Herein, we present a case of pituitary dysfunction due to an unruptured ophthalmic segment internal carotid artery aneurysm and report improved 2-year follow-up results. A 76-year-old male presented with disturbed consciousness due to hyponatremia, which was caused by hypoadrenocorticism resulting from pituitary dysfunction complicated by hypogonadism and hypothyroidism...
2018: Open Medicine (Warsaw, Poland)
Rafał Muc, Agnieszka Saracen, Iwona Grabska-Liberek
Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Diabetes Mellitus, Diabetic Retinopathy and Diabetic Retinal Neuropathy are closely related diseases - originating from incorrectly controlled glycemia, blood pressure and lipid levels in the course of increasing resistance of the body tissues to insulin...
2018: Open Medicine (Warsaw, Poland)
Claudia Casella, Emanuele Capasso, Lucia Terracciano, Paola Delbon, Piergiorgio Fedeli, Francesco Antonio Salzano, Fabio Policino, Massimo Niola
This study originated from events that occurred in 2014 in an Italian hospital, where the embryos of a couple, obtained by means of homologous insemination, were mistakenly implanted into the uterus of another woman who, along with her husband, underwent the same treatment. Faced with this serious adverse circumstance, that gives rise to ethical and legal issues, the authors conducted a comparative examination of how to consider the division of maternity (between biological mother and uterine mother) and the related division of paternity (between genetic father and legal father, husband or partner of the gestational mother)...
2018: Open Medicine (Warsaw, Poland)
Audrius Mikalauskas, Rimantas Benetis, Edmundas Širvinskas, Judita Andrejaitienė, Šarūnas Kinduris, Andrius Macas, Žilvinas Padaiga
Burnout is a syndrome of depersonalization, emotional exhaustion, and low personal accomplishment. Little is known about burnout in physicians. Our objective was to determine the prevalence of burnout among anesthetists and intensive care physicians, and associations between burnout and personal, as well as professional, characteristics. Methods: In total, 220 anesthetists and intensive care physicians were contacted by email, asking them to participate in the study. For depression screening the PHQ-2 questionnaire, for problem drinking, CAGE items were used...
2018: Open Medicine (Warsaw, Poland)
Adelaide Conti, Emanuele Capasso, Claudia Casella, Piergiorgio Fedeli, Francesco Antonio Salzano, Fabio Policino, Lucia Terracciano, Paola Delbon
In Italy, both parents have parental responsibility; as a general principle they have the power to give or withhold consent to medical procedures on their children, including consent for blood transfusion; however these rights are not absolute and exist only to promote the welfare of children. Methods: The Authors discuss ethical and legal framework for Jehovah's Witness parents' refusal of blood transfusion in Italy. They searched national judgments concerning Jehovah's Witness parents' refusal of blood transfusion - and related comments - in national legal databases and national legal journals, and literature on medical literature databases...
2018: Open Medicine (Warsaw, Poland)
Pierpaolo Di Lorenzo, Claudia Casella, Emanuele Capasso, Paola Delbon, Piergiorgio Fedeli, Fabio Policino, Massimo Niola
Dental treatments, as well as simple anatomical and functional repair work, can also be for aesthetic purposes. This is because the anatomical area concerned, i.e. the oral cavity, has a great power of attraction. Aesthetic treatments in general - in particular dental treatments - have been on the rise in recent years, and this has also meant an increase in claims due to patient dissatisfaction with the results obtained. Numerous laws have been introduced that emphasise the need for comprehensive prior information in order to acquire valid consent...
2018: Open Medicine (Warsaw, Poland)
Lin Zhang, Kailong Li, Chengqi Zhang, Xianlong Qi, Ning Zheng, Guangbin Wang
Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. MATERIALS AND METHODS: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation...
2018: Open Medicine (Warsaw, Poland)
Agnė Jakavonytė-Akstinienė, Vytautas Dikčius, Jūratė Macijauskienė
The aim of this study was to assess the possibility of using scales for measuring cognitive and physical functions for a prognosis of care outcomes in elderly patients. METHODOLOGY: The survey was carried out in one of the Vilnius City Hospitals for Nursing and Support Treatment. A total number of 177 respondents were involved in the study. The Mini-Mental State Examination (MMSE), The Barthel Index (BI) and The Morse Fall Scale were used. RESULTS: A statistically significant correlation was revealed between the scores of MMSE and BI (Pearson R = 0...
2018: Open Medicine (Warsaw, Poland)
Wojciech Podraza, Beata Michalczuk, Karolina Jezierska, Hanna Domek, Agnieszka Kordek, Beata Łoniewska, Monika Modrzejewska, Joanna Kot
Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) are diseases that occur only in preterm infants. The etiology of these disorders is multifactorial; however, it is believed that some of the factors in children presenting with BPD affect both the initiation and severity of ROP. The aim of the study was to evaluate the degree of clinical severity of ROP in infants with BPD compared to those without BPD. Methodology: Infants were divided into two groups: the BPD+ study group and BPD- control group...
2018: Open Medicine (Warsaw, Poland)
Jun Hyeok Lim, Jeong-Seon Ryu, Sang Yong Cho, Hyun-Jung Kim, Sang Hoon Jeon, Jung Soo Kim, Hae-Seong Nam, Jae Hwa Cho, Seung Min Kwak, Hong Lyeol Lee
Small-cell lung cancer (SCLC) is a lung cancer histological subtype unusual in its favorable response to cytotoxic chemotherapy. Life-threatening manifestations at presentation are rarely reported and should be an important clinical concern. We report a case of a 63-year-old man presenting with rapid-onset refractory severe thrombocytopenia, development of massive hemoptysis, and death from respiratory failure. This case provides clinicians a reference for this unusual presentation and carries clinical implications for managing SCLC patients...
2018: Open Medicine (Warsaw, Poland)
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