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Open Medicine (Warsaw, Poland)

Hao Zhang, Qing-Xue Cong, Shan-Guo Zhang, Xiu-Wei Zhai, Hui-Feng Li, Shuang-Qi Li
Introduction: The fascin-1 protein is a cytoskeleton-like protein, which can prompt structural changes in cell membranes and affect the integrity of intercellular relations to promote invasion and metastasis of tumor cells. In this study, we researched the expression of fascin-1 in glioma. Material and methods: The fascin-1 protein and mRNA were detected by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Then, we analyzed the relationship between the expression of fascin-1 protein and the clinical pathological characteristics of patients with glioma...
2018: Open Medicine (Warsaw, Poland)
Ersin Hacıyakupoğlu, Derviş Mansuri Yılmaz, Burak Kınalı, Taner Arpacı, Tuğana Akbaş, Sebahattin Hacıyakupoğlu
Chronic subdural hematoma is a frequent type of hemorrhage, which terminates with mortality if not diagnosed and treated early. The aim of this clinical study is to evaluate the patients with unilateral and bilateral recurrent chronic subdural hematoma. The study group consisted of 13 cases with unilateral and bilateral recurrent chronic subdural hematomas who underwent aggressive wide craniotomy, duraectomy, inner and outer membranectomy, dural border coagulation, incision through cortical vein trace and hang up of dural edge, between 2009 - 2016...
2018: Open Medicine (Warsaw, Poland)
Radica Zivkovic Zaric, Jasmina Milovanovic, Nikola Rosic, Dragan Milovanovic, Dejana Ruzic Zecevic, Marko Folic, Slobodan Jankovic
There are many determinants of vancomycin clearance, but these have not been analyzed separately in populations with different levels of renal function, which could be why some important factors have been missed. The aim of our study was to compare the pharmacokinetic parameters and factors that may affect vancomycin pharmacokinetics in groups of patients with normal renal function and in those with chronic kidney failure. The study used a population pharmacokinetic modeling approach, based on plasma vancomycin concentrations and other data from 78 patients with chronic kidney failure and 32 patients with normal renal function...
2018: Open Medicine (Warsaw, Poland)
Caiyuan Mai, Bin Wang, Rong Chen, Dongmei Duan, Lijuan Lv, Qiong Lei, Xiaohong Lin, Jiying Wen, Jianmin Niu
HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets. HELLP is a common life-threatening complication of pregnancy thought to be a variant or complication of preeclampsia. In this case report, we aimed to present a woman with acute postpartum HELLP syndrome complicated by pulmonary edema after caesarean section following severe preeclampsia. Our experience suggests that early detection of HELLP syndrome and timely management will bring good outcomes.
2018: Open Medicine (Warsaw, Poland)
Xianjun Ding, Hong Jiang, Xingyue Hu, Hong Ren, Huaying Cai
To describe the clinical, electrophysiological, and lumbar magnetic resonance imaging (MRI) features of two cases of atypical Guillain-Barré syndrome (GBS). Methods We reported two GBS variant cases with initial and prominent symptoms of low back pain. We analysed their clinical, electrophysiological, and lumbar MRI features. Results Two patients with GBS reported low back pain as the initial and prominent symptom, which was not accompanied by limb weakness. The electrophysiological study showed abnormal F-waves in the common peroneal and tibial nerves, and acute polyradiculoneuropathy in the cauda equina...
2018: Open Medicine (Warsaw, Poland)
Tatjana Kitić Jaklič, Jure Kovač, Matjaž Maletič, Ksenija Tušek Bunc
Background: This study analyses the degree of patient satisfaction regarding the Emergency Medical Services (EMS) by taking into account the waiting time which is considered to be associated with the success of the EMS organizational model. Methodology: Between 1 Jan 2016 and 31 March 2016 a cross-sectional research study among visitors of the EMS clinics in the EMS of the Primary Health Services of Gorenjska was performed. The EUROPEP survey was used for rating the degree of patient satisfaction...
2018: Open Medicine (Warsaw, Poland)
Daniel Kotrych, Szymon Korecki, Paweł Ziętek, Bartosz Kruk, Agnieszka Kruk, Michał Wechmann, Adam Kamiński, Katarzyna Kotrych, Andrzej Bohatyrewicz
BACKGROUND: CERAMENT™|BONE VOID FILLER is an injectable and moldable ceramic bone substitute material intended for bone voids. The material consists of hydroxyapatite and calcium sulfate hemihydrate. The aim of this study is to present the first long-term results following open curettage of benign bone tumors and tumor-like lesions and void filling with this novel injectable and synthetic bone graft. METHODS: Thirty three patients were enrolled into the study between June 2013 and October 2014 ...
2018: Open Medicine (Warsaw, Poland)
Jia Xu, Long Pang, Xiao Xue Ma, Jian Hu, Yuan Tian, Ya Li Yang, Dan Dan Sun
Vancomycin has been the primary agent used to treat serious Methicillin-resistant Staphylococcus aureus (MRSA) infection for many years. However, the rise of MRSA infection rates and the extensive use of vancomycin have led to the emergence of reduced vancomycin susceptibility. Therefore, four typical Staphylococcus aureus ( S. aureus) strains from different clinical specimens were derivated by vancomycin in vitro to better clarify their phenotypic and molecular characteristics. Some experiments, such as stepwise selection of vancomycin-resistant strains, pulsed-field gel electrophoresis (PFGE), antimicrobial susceptibility test, population analysis profile-area under the curve (PAP-AUC), molecular typing, transmission electron microscopy, δ-hemolysin expression, autolysis assay, biofilm assay and quantitative real-time polymerase chain reaction (qPCR) for gene expression were carried out to compare the derivated bacteria with their parental strains...
2018: Open Medicine (Warsaw, Poland)
Jun Ni, Dan Wang, Sheng Wang
The CC chemokine receptor 5 (CCR5) is a chemokine receptor which is widely expressed in several immune cells involved in the inflammatory responses. Previous published studies revealed the relation of the CCR5 gene (CCR5-delta32) with the risk of HIV-1 infection, but the results are debatable and inconclusive. Here by meta-analysis, we have systematically evaluated the relation between the CCR5-delta32 polymorphism and the risk of HIV-1 infection. A comprehensive search in PubMed, EMBASE, CNKI, Cochrane Library, and WanFang database was performed up to April 15, 2018...
2018: Open Medicine (Warsaw, Poland)
Di Lin, Jian Chen, Yan Yang, Jun Cheng, Changgui Sun
Background: This research is aimed to study the resistance and molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP). Methodology: 38 isolated CRKP strains were collected from clinical specimens. Results: The resistance rates were more than 70.0%. Ampicillin had the highest rates among them (100.0%). 34 strains (89.5%) among the 38 CRKP strains carried bla KPC-2 gene, and 3 strains (7.9%) carried bla IMP-4 gene...
2018: Open Medicine (Warsaw, Poland)
Halil Taskaynatan, Ahmet Alacacioglu, Yuksel Kucukzeybek, Umut Varol, Yasar Yildiz, Tarik Salman, Utku Oflazoglu, Mustafa Oktay Tarhan
Background: Mean platelet volume (MPV) is a parameter that increases during thrombotic and cardiovascular events. Tamoxifen (Tmx) and aromatase inhibitors (AIs), which are adjuvant endocrine therapies, may cause serious side effects, such as vascular thrombosis. The present study investigated the changes in MPV values of breast cancer patients receiving long-term adjuvant hormone therapy and the relationship of MPV with adverse effects of hormonotherapy. Methods: Data of 261 patients who had pathologically confirmed estrogen or progesterone receptor positive invasive breast cancer and had received hormonotherapy for at least a 5-year period were retrospectively analyzed...
2018: Open Medicine (Warsaw, Poland)
Yuemei Li, Min Zhang, Xinhua Zheng
Objective: To explore the relationships of NLRC5 with clinicopathological characteristics and prognosis of gastric cancer patients. Methods: A total of 97 gastric cancer patients undergoing radical gastrectomy were enrolled. All patients were diagnosed by immunohistochemical staining. The relationship between NLRC5 expression and clinicopatho-logical characteristics of gastric cancer was analyzed via univariate and multivariate Cox regressions. Results: NLRC5 expression was positive in 70 cases (72...
2018: Open Medicine (Warsaw, Poland)
Natalija Skorobogatova, Nida Žemaitienė, Kastytis Šmigelskas, Rasa Tamelienė, Eglė Markūnienė, Dalia Stonienė
Our study aimed to find out the views of nurses working in neonatal intensive care units about the limits of professional competencies and to identify situations where the limits are crossed. Methods: The research employed the focus group method. For this research we had three focus groups with nurses working in neonatal intensive care units. The results of the study were analysed using the thematic analysis described in Braun and Clarke. Results and conclusions: Based on our research findings, it can be stated that the limits of professional competence of nursing staff working in neonatal intensive care units are defined and clear, but nurses often perform actions exceeding their competencies...
2018: Open Medicine (Warsaw, Poland)
Chun Zhu, Mei-Ling Tong, Xia Chi
Study advances with a childhood case of partial deletion of the long arm of chromosome 7. The patient is a 36-month-old girl with growth retardation, mild mental retardation and delayed bone age. She showed no signs of hypotelorism, upslanting palpebral fissures, epicanthal folds, low-set ears, or flat and broad nasal bridge. Microarray testing using the Affymetrix CytoScan HD array revealed an approximately 58 kb deletion at 7q31.1 in the girl and her father, suggesting paternal origin. As the patient had no characteristic facial features, 7q deletions had not been considered...
2018: Open Medicine (Warsaw, Poland)
Jianjiang Ruan, Yueqiao Zhang, Hong Ren
Objective: The aim of this study was to assess the diagnostic value of PET/CT for metastatic lymph nodes in cervical cancer patients. Methods: Searching in the databases including PubMed, Embase, Web of Science, Cochrane Library and Google Scholar about non-invasive modalities for detecting lymph nodes metastases during 2000~2017. Following further screening, the extracted effective data were calculated by Meta-Disc 1.4 software, such as sensitivity (SEN), specificity (SPE), positive likelihood (LR+), and negative likelihood ratio (LR-)...
2018: Open Medicine (Warsaw, Poland)
Michał Wechmann, Paweł Ziętek, Łukasz Sieczka, Konrad Dobiecki, Joanna Krzywda-Pogorzelska, Radomir Czajka, Adam Kamiński, Andrzej Bohatyrewicz, Daniel Kotrych
Disturbed or delayed healing remains one of the most serious fracture-related complications, despite bone capacity for internal regeneration and reabsorption. Considerable progress in the understanding and treatment of fractures has been noted. The aim of our study was to evaluate treatment outcome in patients (smokers and non-smokers) with post-traumatic pseudoarthrosis. Hypothesis: Determinate when administration of growth factors is most beneficial, and whether it accelerates bone union...
2018: Open Medicine (Warsaw, Poland)
Teruki Miyake, Sakiko Yoshida, Shinya Furukawa, Takenori Sakai, Fujimasa Tada, Hidenori Senba, Shin Yamamoto, Yohei Koizumi, Osamu Yoshida, Masashi Hirooka, Teru Kumagi, Tetsuju Niiya, Hiroaki Miyaoka, Abe Masanori, Bunzo Matsuura, Yoichi Hiasa
Background: There are few effective medications for non-alcoholic steatohepatitis (NASH). We investigated the efficacy of ipragliflozin (selective sodium-glucose cotransporter-2 inhibitor [SGLT2I]) for the treatment of patients with type 2 diabetes mellitus (T2DM) complicated by non-alcoholic fatty liver disease (NAFLD). Methods: We prospectively enrolled patients with T2DM complicated by NAFLD treated at our institutions from January 2015 to December 2016. Patients received oral ipragliflozin (50 mg/day) once daily for 24 weeks...
2018: Open Medicine (Warsaw, Poland)
Shinya Imai, Manabu Akahane, Yuto Konishi, Tomoaki Imamura
Performing accurate diagnosis using computed tomography (CT) in emergency medicine may reduce mortality rates in various diseases. In this observational, correlational and cross-sectional study, we conducted multiple regression analyses to investigate the relationship between CT utilization rates and mortality. In addition, we estimated the annual net profits from CT to show the profitability of introducing a CT system in each Japanese prefecture. We conducted a multiple regression analysis to investigate correlations between CT utilization rates and mortality from each disease adjusted for the population density, number of doctors, as well as transportation time to the medical institution...
2018: Open Medicine (Warsaw, Poland)
Wioletta Medrzycka-Dabrowska, Katarzyna Lewandowska, Katarzyna Kwiecień-Jaguś, Katarzyna Czyż-Szypenbajl
Background: Sleep disturbances in intensive care unit (ICU) patients have been studied worldwide for over 30 years. Factors contributing to sleep disturbances are still being identified, and therapeutic procedures aimed at the mitigation of such ailments are consequently being developed. Objectives: The aim of this study was to review the literature on sleep disturbances in intensive care unit patients. Material and Methods: MEDLINE PubMed, OVID, Web of Science, and EBSCO databases have been searched using adequate keywords...
2018: Open Medicine (Warsaw, Poland)
Ismail Yaqub Maolood, Yahya Eneid Abdulridha Al-Salhi, Songfeng Lu
In this study, an effective means for detecting cancer region through different types of medical image segmentation are presented and explained. We proposed a new method for cancer segmentation on the basis of fuzzy entropy with a level set (FELs) thresholding. The proposed method was successfully utilized to segment cancer images and then efficiently performed the segmentation of test ultrasound image, brain MRI, and dermoscopy image compared with algorithms proposed in previous studies. Results showed an excellent performance of the proposed method in detecting cancer image segmentation in terms of accuracy, precision, specificity, and sensitivity measures...
2018: Open Medicine (Warsaw, Poland)
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