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Translational Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/30363838/salvage-liver-transplant-for-hepatocellular-carcinoma-rescues-and-benefits
#1
REVIEW
Shusen Zheng, Qinfen Xie, Jinkun Cheng
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China, primary liver transplantation (PLT) and hepatic resection are thought to be the prime and more reasonable treatment. But due to the situation of donor shortage and a higher risk of tumor recurrence, salvage liver transplantation (SLT) is gradually being applied to the patients with HCC, and is confirmed as an effective and feasible treatment for patients. However, the indications and transplantation criteria for SLT still remain controversial...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363804/the-current-role-of-laparoscopic-resection-for-hcc-a-systematic-review-of-past-ten-years
#2
REVIEW
Stefano Di Sandro, Maria Danieli, Fabio Ferla, Andrea Lauterio, Riccardo De Carlis, Laura Benuzzi, Vincenzo Buscemi, Isabella Pezzoli, Luciano De Carlis
The use of laparoscopic liver resection (LLR) has progressively spread in the last 10 years. Several studies have shown the superiority of LLR to open liver resection (OLR) in term of perioperative outcomes. With this review, we aim to systematically assess short-term and long-term major outcomes in patients who underwent LLR for hepatocellular carcinoma (HCC) in order to illustrate the advantages of minimally invasive liver surgery. Through an advanced PubMed research, we selected all retrospective, prospective, and comparative clinical trials reporting short-term and long-term outcomes of any series of patients with diagnosis of HCC who underwent laparoscopic or robotic resection...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363796/can-nut-consumption-improve-colon-cancer-survival
#3
EDITORIAL
Dagfinn Aune
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363779/surgical-treatment-of-gastrointestinal-stromal-tumors-of-the-duodenum-a-literature-review
#4
Georgi Popivanov, Mihail Tabakov, George Mantese, Roberto Cirocchi, Irene Piccinini, Vito D'Andrea, Piero Covarelli, Carlo Boselli, Francesco Barberini, Renata Tabola, Ursi Pietro, Davide Cavaliere
Background: Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumours in the digestive tract. The duodenal GIST (dGIST) is the rarest subtype, representing only 4-5% of all GIST, but up to 21% of the resected ones. The diagnostic and therapeutic management of dGIST may be difficult due to the rarity of this tumor, its anatomical location, and the clinical behavior that often mimic a variety of conditions; moreover, there is lack of consent for their treatment. This study has evaluated the scientific literature to provide consensus on the diagnosis of dGIST and to outline possible options for surgical treatment...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363763/transplantation-for-colorectal-metastases-on-the-edge-of-a-revolution
#5
REVIEW
Axel Andres, Graziano Oldani, Thierry Berney, Philippe Compagnon, Pål-Dag Line, Christian Toso
Liver transplantation (LT) has become the standard of care for selected primary and secondary malignancies. Considered a contra-indication to transplantation until recently, unresectable colorectal liver metastases (CRLM) have gained interest since the publication of the SECA trial by the University of Oslo. It showed a 5-year overall survival of 60%, comparable to the one of standard transplant indication. This report generated multiple questions about the place of LT for CRLM and gave raise to several trials aiming at answering them...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363757/precision-care-for-barrett-s-esophagus
#6
REVIEW
George Triadafilopoulos, Shai Friedland
Modern recognition and management of Barrett's esophagus, a precursor to esophageal adenocarcinoma depends on diagnostic accuracy, risk assessment, technical expertise and consideration of many options to best tailor therapy for every patient. Concomitant management of acid reflux is essential, frequently with proton pump inhibitors. Ablation and resection favorably affect the evolution towards cancer. Using precision medicine tools, such as imaging, molecular diagnostics and analytics may lead to cost- and comparatively-effective therapies ultimately aiming at cancer prevention...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363754/transplantation-for-hepatocellular-cancer-pushing-to-the-limits
#7
REVIEW
Quirino Lai, Alessandro Vitale
Milan criteria (MC) represents the cornerstone in the selection of patients with hepatocellular cancer (HCC) waiting for liver transplantation (LT). MC represent the precursor of the scores based on the idea of "utility": in other terms, the scoring systems typically used in the field of LT oncology present the exclusive aim of selecting the cases with the best post-LT outcomes. However, some other scores have been proposed specifically investigating the risk of death or tumour progression during the waiting list...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363746/vascular-tumours-of-the-liver-a-particular-story
#8
REVIEW
Jan Lerut, Samuele Iesari
Vascular tumours of the liver represent an underrated chapter of medical and surgical hepatology. These tumours cover a wide spectrum ranging from the frequent and most benign hepatic haemangioma (HH), via the rare and intermediately aggressive hepatic epithelioid haemangioendothelioma (HEHE) to the rare and most malignant hepatic haemangiosarcoma (HHS). In contrast to the treatment algorithms for hepatocellular and cholangiocellular cancer, the diagnostic and therapeutic approaches to HEHE and HHS are not well developed...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363737/the-challenges-of-evolving-rome-criteria-for-functional-dyspepsia
#9
EDITORIAL
Craig A Friesen, Jennifer V Schurman
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363724/hepatocellular-carcinoma-in-children-hepatic-resection-and-liver-transplantation
#10
REVIEW
Roberta Angelico, Chiara Grimaldi, Maria Cristina Saffioti, Aurora Castellano, Marco Spada
Hepatocellular carcinoma (HCC) is a rare malignancy in children and at the time of diagnosis up to 80% of pediatric HCC are unresectable due to large and multiple lesions. The majority of pediatric HCC occurs on a background of normal liver, and consequently the absence of concomitant chronic liver disease generally allows tolerating pre- and post-operative chemotherapy. Based on the large experiences of adult HCC and pediatric hepatoblastoma, in the last years a multidisciplinary aggressive treatment composed of surgical resection and chemotherapy (based on cisplatin and doxorubicin) has been proposed, improving patient outcomes and recurrence rate in children with HCC...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363713/resection-for-intrahepatic-cholangiocellular-cancer-new-advances
#11
REVIEW
Daniel R Waisberg, Rafael S Pinheiro, Lucas S Nacif, Vinicius Rocha-Santos, Rodrigo B Martino, Rubens M Arantes, Liliana Ducatti, Quirino Lai, Wellington Andraus, Luiz C D'Albuquerque
Intrahepatic cholangiocarcinoma (ICC) is the second most prevalent primary liver neoplasm after hepatocellular carcinoma (HCC), corresponding to 10% to 15% of cases. Pathologies that cause chronic biliary inflammation and bile stasis are known predisposing factors for development of ICC. The incidence and cancer-related mortality of ICC is increasing worldwide. Most patients remain asymptomatic until advance stage, commonly presenting with a liver mass incidentally diagnosed. The only potentially curative treatment available for ICC is surgical resection...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363705/new-classification-rome-iv-functional-dyspepsia-and-subtypes
#12
EDITORIAL
Seiji Futagami, Hiroshi Yamawaki, Shuhei Agawa, Kazutoshi Higuchi, Go Ikeda, Hiroto Noda, Kumiko Kirita, Teppei Akimoto, Mako Wakabayashi, Noriko Sakasegawa, Yasuhiro Kodaka, Nobue Ueki, Tetsuro Kawagoe, Katsuhiko Iwakiri
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363698/resection-for-klatskin-tumors-technical-complexities-and-results
#13
REVIEW
Ivan Capobianco, Jens Rolinger, Silvio Nadalin
Klatskin's tumors, actually-redefined as perihilar cholangiocarcinoma (phCCA) do represent 50-70% of all CCAs and develop in a context of chronic inflammation and cholestasis of bile ducts. Surgical resection provides the only chance of cure for this disease but is technically challenging because of the complex, intimate and variable relationship between biliary and vascular structures at this location. Five years survival rates range between 25-45% (median 27-58 months) in case of R0 resection and 0-23% (median 12-21 months) in case of R1 resection respectively...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363693/effect-of-fluorouracil-leucovorin-and-oxaliplatin-with-or-without-onartuzumab-in-epidermal-growth-factor-receptor-2-negative-mesenchymal-epithelial-transition-positive-gastroesophageal-adenocarcinoma-is-it-a-real-failure
#14
EDITORIAL
Jimmy T Efird, Charulata Jindal, Timothy Fitzgerald, Tithi Biswas
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363682/resection-for-hepatocellular-cancer-overpassing-old-barriers
#15
REVIEW
Francesco Giovanardi, Quirino Lai, Alessandra Bertacco, Alessandro Vitale
Several recent studies have shown that the selection limits commonly used for patients with hepatocellular cancer (HCC) potentially requiring a liver resection (LR) are too restrictive. The present review aims at investigating the studies showing that LR is no longer a treatment suitable only for highly selected patients, but also for patients selectively presenting one-to-more negative factors. Several specific variables have been investigated, none of them showing to be an absolute contraindication for LR: age; single vs...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30363643/role-of-associating-liver-partition-and-portal-vein-ligation-in-staged-hepatectomy-alpps-strategy-for-colorectal-liver-metastases
#16
REVIEW
Arezou Abbasi, Amir A Rahnemai-Azar, Katiuscha Merath, Sharon M Weber, Daniel E Abbott, Mary Dillhoff, Jordan Cloyd, Timothy M Pawlik
Colorectal carcinoma (CRC) is the third leading cause of cancer-related death in the United States. The liver is the most frequent site of metastasis and a key determinant of survival in patients with isolated colorectal liver metastasis (CRLM). Surgical resection remains the only hope for prolonged survival in patients with CRLM. However, most patients are deemed to be unresectable at presentation due to a small future liver remnant (FLR) and fear of post-hepatectomy liver failure. Procedures such as portal vein ligation or embolization (PVL/PVE) followed by hepatectomy have been established as standard methods to increase FLR volume, but have limitations dependent upon extent of disease and patient's ability to grow the liver remnant...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30225390/a-systematic-review-and-meta-analysis-of-treatment-for-hepatorenal-syndrome-with-traditional-chinese-medicine
#17
Tingxue Song, Xiaozhong Guo, Lichun Shao, Mingyu Sun, Fernando Gomes Romeiro, Dan Han, Wenchun Bao, Xingshun Qi
Background: Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver diseases. It has been reported that traditional Chinese medicine (TCM) may improve liver function, delay disease progression, alleviate symptoms, and improve quality of life in HRS patients. The study aims to systematically review the efficacy of TCM for the treatment of HRS. Methods: Publications were searched electronically from China National Knowledge Infrastructure (CNKI), Wanfang, VIP, PubMed, and EMBASE databases...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30225389/revisiting-the-prognostic-relevance-of-muscle-mass-among-non-metastatic-colorectal-cancer
#18
EDITORIAL
Omar Abdel-Rahman, Winson Y Cheung
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30225388/pediatric-gastrointestinal-stromal-tumors-a-review-of-diagnostic-modalities
#19
REVIEW
Hallie J Quiroz, Brent A Willobee, Matthew S Sussman, Bradley R Fox, Chad M Thorson, Juan E Sola, Eduardo A Perez
Gastrointestinal stromal tumors are exceedingly rare tumors in the pediatric population, as a result many clinicians either may never see this diagnosis or will encounter it only a few times throughout their careers. It is imperative in the pediatric population to follow appropriate steps to ensure a swift diagnosis and referral to specialized centers that are equipped with the multidisciplinary teams accustomed to treating rare diseases. This review aims to discuss the most recent data available on the diagnostic modalities utilized in cases of suspected Pediatric GIST...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/30225387/current-treatment-strategies-in-pediatric-gastrointestinal-stromal-cell-tumor
#20
REVIEW
Brent A Willobee, Hallie J Quiroz, Matthew S Sussman, Chad M Thorson, Juan E Sola, Eduardo A Perez
Gastrointestinal stromal tumors (GIST) are exceedingly rare tumors in the pediatric population. As a result, many clinicians either may never see this diagnosis or will encounter it only a few times throughout their careers. Additionally, the more we discover about this disease, it becomes evident that it represents a distinct clinical entity from adult GIST. Many of the treatments and strategies used to combat the adult tumor are either ineffective or may be harmful to the pediatric population with this disease...
2018: Translational Gastroenterology and Hepatology
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