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Translational Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/29780900/prophylactic-antibiotics-at-the-time-of-elective-cholecystectomy-are-effective-in-reducing-the-post-operative-infective-complications-a-systematic-review-and-meta-analysis
#1
Muhammad S Sajid, Joanna Bovis, Saad Rehman, Krishna K Singh
Background: The objective of this article is to evaluate the role of prophylactic antibiotics in preventing the infective complications in patients undergoing elective laparoscopic cholecystectomy (ELC). Methods: A systematic review of the literature on the published randomized, controlled reporting the role of prophylactic antibiotics in preventing the infective complications in patients undergoing ELC was undertaken using the principles of meta-analysis. Results: Twenty-five RCTs on 6,138 patients evaluating the infective complications in patients undergoing ELC were systematically analysed...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780899/perspectives-on-the-evolving-state-of-the-art-management-of-gastrointestinal-stromal-tumours
#2
REVIEW
Zoltan Szucs, Robin L Jones
Gastrointestinal stromal tumours (GISTs) represent a very exciting tumour entity for the medical oncologist. There has been extensive clinical and preclinical research dissecting the natural behaviour, molecular landscape and therapeutic responsiveness of this rare mesenchymal tumour. Various molecular subtypes of GIST have a differing prognostic and predictive relevance in the state of the art management of the disease. Emerging mature clinical trial data gathered over the last one and half decade provided substantial molecular profiling information in understanding the success and eventual failure of treatment...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780898/sumoylation-and-phosphorylation-cross-talk-in-hepatocellular-carcinoma
#3
REVIEW
Maria Lauda Tomasi, Komal Ramani
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The large spectrum of protein post-translational modification (PTM) includes numerous critical signaling events that occur during neoplastic transformation. PTMs occur to nearly all proteins and increase the functional diversity of proteins. We have reviewed the role of two major PTMs, SUMOylation and phosphorylation, in the altered signaling of key players in HCC...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682626/adenoma-detection-rate-the-perfect-colonoscopy-quality-measure-or-is-there-more
#4
EDITORIAL
Brian Liem, Neil Gupta
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682625/review-of-management-options-for-pancreatic-pseudocysts
#5
REVIEW
Christos Agalianos, Ioannis Passas, Ioannis Sideris, Demetrios Davides, Christos Dervenis
Pancreatic pseudocysts (PPs) present a challenging problem for physicians dealing with pancreatic disorders. Their management demands the co-operation of surgeons, radiologists and gastroenterologists. Historically, they have been treated either conservatively or surgically, with acceptable rates of complications and recurrence. However, recent advances in radiology and endoscopy, have leaded physicians to implement percutaneous and endoscopic drainage (ED) into their treatment algorithms. Moreover, laparoscopic surgery, with its advantages, has become an attractive alternative choice when surgical drainage (SD) is required...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682624/non-exposed-endoscopic-wall-inversion-surgery-for-gastrointestinal-stromal-tumor
#6
Takashi Mitsui, Hiroharu Yamashita, Susumu Aikou, Keiko Niimi, Mitsuhiro Fujishiro, Yasuyuki Seto
Laparoscopic and endoscopic cooperative surgery (LECS) is an accepted method of laparoscopic wedge resection, which is minimally invasive, for gastrointestinal stromal tumors (GISTs). We established a type of LECS achieving a full-thickness resection, non-exposed endoscopic wall-inversion surgery (NEWS), in an effort to prevent exposure of the peritoneal cavity to gastric intraluminal contents. We employed this surgical technique in 28 gastric GIST patients. We failed to complete NEWS in the initial two patients and in one patient with a large tumor (40 mm × 35 mm), but otherwise carried out the procedure successfully...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682623/long-term-adjuvant-treatment-of-gastrointestinal-stromal-tumors-gist-with-imatinib-a-comment-and-reflection-on-the-persist-5-study
#7
EDITORIAL
Silke Cameron
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682622/risk-of-hepatocellular-carcinoma-for-patients-treated-with-direct-acting-antivirals-steps-after-hepatitis-c-virus-eradication-to-achieve-elimination
#8
EDITORIAL
Mei-Hsuan Lee
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682621/surgery-for-metastatic-gastrointestinal-stromal-tumor-to-whom-and-how-to
#9
REVIEW
Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Yoshifumi Morita, Takanori Sakaguchi, Hiroyuki Konno, Hiroya Takeuchi
Although imatinib is a standard treatment for metastatic or recurrent gastrointestinal stromal tumors (GISTs), acquired c-kit mutations reportedly cause secondary resistance to imatinib. Sunitinib is a tyrosine kinase inhibitor (TKI) that can be used as second-line therapy in imatinib-resistant or -intolerant GISTs. For sunitinib-resistant or -intolerant GISTs, regorafenib is a standard third-line treatment. Although TKI therapies have revolutionized the treatment of recurrent or metastatic GISTs, they cannot cure GISTs...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552664/editorial-on-quality-standards-in-upper-gastrointestinal-endoscopy-a-position-statement-of-the-british-society-of-gastroenterology-bsg-and-association-of-upper-gastrointestinal-surgeons-of-great-britain-and-ireland-augis
#10
EDITORIAL
https://www.readbyqxmd.com/read/29552663/micromanagement-of-drug-resistant-advanced-gastrointestinal-stromal-tumors-regorafenib-new-ammunition-in-battling-exon-17-mutations
#11
EDITORIAL
Alexander J Eckardt, Ortwin Klein
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552662/asian-consensus-guidelines-for-gastrointestinal-stromal-tumor-what-is-the-same-and-what-is-different-from-global-guidelines
#12
REVIEW
Toshirou Nishida
There are some disparities between the clinical practice and profiles of cancer in Asia and those in Europe & North America. In Asia, surgical oncologists still have a major role in the multidisciplinary therapy of gastrointestinal stromal tumor (GIST), whereas medical oncologists hold this status in the West. Although the incidence of clinical GIST is considered similar between the two areas, small gastric GISTs are more frequently treated by surgery in East Asia compared with Europe & North America...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552661/swog-study-shows-significant-long-term-overall-survival-for-advanced-gastrointestinal-stromal-tumor-patients-with-imatinib-treatment
#13
EDITORIAL
Marcel Trautmann, Sebastian Huss, Wolfgang Hartmann, Eva Wardelmann
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552660/recent-innovations-in-the-management-of-hepatocellular-cancer-in-the-setting-of-liver-transplantation-preface
#14
Giovanni Battista Levi Sandri, Quirino Lai
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552659/management-of-rectal-gastrointestinal-stromal-tumor
#15
REVIEW
Hitoshi Kameyama, Tatsuo Kanda, Yosuke Tajima, Yoshifumi Shimada, Hiroshi Ichikawa, Takaaki Hanyu, Takashi Ishikawa, Toshifumi Wakai
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. However, rectal GIST is rare, the incident rate of it is approximately 5% of all GISTs. Rectal GIST symptoms generally include bleeding and/or pain and occasionally, urinary symptoms. Immunohistochemical evaluation finds that most rectal GIST tumors are CD117 (KIT) positive, and are sometimes CD34, platelet-derived growth factor receptor alpha (PDGFRA), smooth muscle actin, S-100, or vimentin positive...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29441372/quality-standards-and-performance-measures-steps-to-high-quality-diagnostic-endoscopy
#16
EDITORIAL
Yu Kyung Cho
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29441371/gastrointestinal-stromal-tumor-of-the-esophagus-current-issues-of-diagnosis-surgery-and-drug-therapy
#17
REVIEW
Jun Hihara, Hidenori Mukaida, Naoki Hirabayashi
Gastrointestinal stromal tumors (GISTs) often arise in the stomach and small intestine, while esophageal GISTs are rare. Due to their rarity, clinicopathological data on esophageal GISTs are extremely limited, and this results in a lack of clear recommendations concerning optimal surgical management for esophageal GISTs. It is difficult to distinguish esophageal GIST from leiomyoma, the most frequent esophageal mesenchymal tumor, prior to resection, because the two types of tumors appear similar on computed tomography (CT), endoscopic ultrasound (EUS), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29441370/adenoma-detection-rate-is-it-the-master-key-for-the-colonoscopy-quality-indicator
#18
EDITORIAL
Su Young Kim, Hyun-Soo Kim
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29441369/limited-activity-of-metronomic-cyclophosphamide-and-pembrolizumab-for-soft-tissue-sarcomas
#19
EDITORIAL
Irvin C Lien, Seth M Pollack
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29441368/neoadjuvant-therapy-for-gastrointestinal-stromal-tumor
#20
REVIEW
Takashi Ishikawa, Tatsuo Kanda, Hitoshi Kameyama, Toshifumi Wakai
Molecular-targeting therapy using tyrosine kinase inhibitor imatinib mesylate is effective for metastasis/recurrent gastrointestinal stromal tumors (GISTs). Likewise, imatinib would be effective in the neoadjuvant therapy for high-risk GIST. Neoadjuvant therapy may have the potential to increase the complete resection rate and to avoid the surgical rupture by decreasing the tumor size. Thereby, it is expected that improvement of recurrence rate and survival rate can be obtained by neoadjuvant therapy. Neoadjuvant therapy is also expected to be favored from the viewpoint of organ/function preservation by tumor shrinkage...
2018: Translational Gastroenterology and Hepatology
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