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Translational Gastroenterology and Hepatology

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https://www.readbyqxmd.com/read/29971262/vitamin-d-a-brief-overview-of-its-importance-and-role-in-inflammatory-bowel-disease
#1
REVIEW
Kiran Mudambi, Dorsey Bass
Vitamin D has traditionally been known for its regulation of bone metabolism and homeostasis, but emerging evidence suggests that it also has a broad function in immune regulation, and inflammatory bowel disease (IBD). The etiology of IBD is thought to be multifactorial but stems in part due to the deregulation of the immune response to environmental factors in the setting of a pre-existing genetic disposition. Vitamin D, based on its mechanistic role at the cellular level in T-cell trafficking, had been postulated to have a direct effect on the immune system, This alludes to the fact that vitamin D may have the ability to not only potentiate the IBD phenotype, but also in doing so, its supplementation may serve a therapeutic role in amelioration of the diseased state...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971261/meta-analysis-of-randomized-controlled-trials-only-exploring-the-role-of-single-incision-laparoscopic-surgery-versus-conventional-multiport-laparoscopic-surgery-for-colorectal-resections
#2
Madhusoodhana Hebbar, Waleed Riaz, Parv Sains, Mirza Khurrum Baig, Muhammad Shafique Sajid
Background: The objective of this article is to evaluate the surgical outcomes in patients undergoing single incision laparoscopic surgery (SILS) versus conventional multi-incision laparoscopic surgery (MILS) for colorectal resections. Methods: The data retrieved from the published randomized controlled trials (RCTs) reporting the surgical outcomes in patients undergoing SILS versus MILS for colorectal resections was analysed using the principles of meta-analysis...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971260/improving-the-mucosal-visualization-at-gastroscopy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-reporting-the-role-of-simethicone-%C3%A2-n-acetylcysteine
#3
Muhammad Shafique Sajid, Saad Rehman, Fergus Chedgy, Krishna K Singh
Background: The objective of this article is to study the role of Simethicone ± N-acetylcysteine in improving the mucosal visualization during oesophago-gastro-duodenoscopy (OGD). Methods: The data retrieved from the published randomized controlled trials (RCTs) reporting the role of Simethicone ± N-acetylcysteine during OGD was analysed using the principles of meta-analysis. The summated outcome of continuous variables was expressed as standardized mean difference (SMD) and dichotomous data was presented in odds ratio (OR)...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971259/does-july-effect-exist-in-colonoscopies-performed-at-teaching-hospitals
#4
Rupak Desai, Upenkumar Patel, Hemant Goyal
Background: To compare the outcomes of the colonoscopies between the early (July-September) and the later (April-June) academic year at the urban-teaching hospitals. Methods: Our study cluster was derived from the National Inpatient Sample (NIS) database for the years 2010-2014. International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9 CM) procedure codes were used to identify the adult patients who underwent inpatient colonoscopy at urban-teaching hospitals...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971258/differential-diagnosis-of-gastrointestinal-stromal-tumor-by-histopathology-and-immunohistochemistry
#5
REVIEW
Seiichi Hirota
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs account for approximately 80% of the clinically relevant GI mesenchymal tumors. Although most GISTs show spindle cell morphology, 10-15% of GISTs show pure epithelioid configuration. Therefore, not only spindle cell tumors but also epithelioid cell ones developing in the GI tract are subject to the differential diagnoses of GISTs. GISTs are basically positive for KIT, a receptor tyrosine kinase (RTK) encoded by protooncogene c -kit , by immunohistochemistry, but approximately 5% of GISTs are only weakly or barely positive for KIT...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971257/endoscopic-resection-or-surgical-management-for-nonampullary-duodenal-neoplasms
#6
EDITORIAL
Joon Sung Kim, Byung-Wook Kim
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971256/a-good-response-to-glucocorticoid-for-sub-acute-liver-failure-a-case-report
#7
Zhaohui Bai, Hongyu Li, Kexin Zheng, Jingqiao Zhang, Xintong Zhang, Jiao Deng, Zhe Jia, Xinmiao Zhou, Xiaozhong Guo, Xingshun Qi
Liver failure is a severe clinical syndrome presenting with coagulation dysfunction, jaundice, hepatic encephalopathy, and ascites. It often has a dismal prognosis. The role of glucocorticoid for the treatment of liver failure is unclear. In this paper, we reported that a female patient with sub-acute liver failure had a good response to glucocorticoid.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971255/microenvironment-and-tumor-cells-two-targets-for-new-molecular-therapies-of-hepatocellular-carcinoma
#8
REVIEW
Laura Amicone, Alessandra Marchetti
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops. Inflammation and the consequent fibro/cirrhosis, derived from chronic injuries of several origins (viral, toxic and metabolic) and observable in almost all oncological patients, represents the most powerful risk factor for HCC and, at the same time, an important obstacle to the efficacy of systemic therapy...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29971254/lateral-cavo-caval-shunt-an-alternative-veno-venous-bypass-in-liver-surgery
#9
Michel Rayar, Giovanni Battista Levi Sandri, Marc Blondeau, Mohamed Lakehal, Véronique Desfourneaux, Laurent Sulpice, Bernard Meunier, Karim Boudjema
When inferior vena cava (IVC) resection is mandatory during liver surgery, use of a veno-venous bypass (VVB) is usually required despite its specific related adverse events. We describe a safe and alternative technique which allows both derivation of the portal and the caval blood flow by performing a lateral cavo-caval shunt using a prosthetic graft.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780900/prophylactic-antibiotics-at-the-time-of-elective-cholecystectomy-are-effective-in-reducing-the-post-operative-infective-complications-a-systematic-review-and-meta-analysis
#10
Muhammad S Sajid, Joanna Bovis, Saad Rehman, Krishna K Singh
Background: The objective of this article is to evaluate the role of prophylactic antibiotics in preventing the infective complications in patients undergoing elective laparoscopic cholecystectomy (ELC). Methods: A systematic review of the literature on the published randomized, controlled reporting the role of prophylactic antibiotics in preventing the infective complications in patients undergoing ELC was undertaken using the principles of meta-analysis. Results: Twenty-five RCTs on 6,138 patients evaluating the infective complications in patients undergoing ELC were systematically analysed...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780899/perspectives-on-the-evolving-state-of-the-art-management-of-gastrointestinal-stromal-tumours
#11
REVIEW
Zoltan Szucs, Robin L Jones
Gastrointestinal stromal tumours (GISTs) represent a very exciting tumour entity for the medical oncologist. There has been extensive clinical and preclinical research dissecting the natural behaviour, molecular landscape and therapeutic responsiveness of this rare mesenchymal tumour. Various molecular subtypes of GIST have a differing prognostic and predictive relevance in the state of the art management of the disease. Emerging mature clinical trial data gathered over the last one and half decade provided substantial molecular profiling information in understanding the success and eventual failure of treatment...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29780898/sumoylation-and-phosphorylation-cross-talk-in-hepatocellular-carcinoma
#12
REVIEW
Maria Lauda Tomasi, Komal Ramani
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. The large spectrum of protein post-translational modification (PTM) includes numerous critical signaling events that occur during neoplastic transformation. PTMs occur to nearly all proteins and increase the functional diversity of proteins. We have reviewed the role of two major PTMs, SUMOylation and phosphorylation, in the altered signaling of key players in HCC...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682626/adenoma-detection-rate-the-perfect-colonoscopy-quality-measure-or-is-there-more
#13
EDITORIAL
Brian Liem, Neil Gupta
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682625/review-of-management-options-for-pancreatic-pseudocysts
#14
REVIEW
Christos Agalianos, Ioannis Passas, Ioannis Sideris, Demetrios Davides, Christos Dervenis
Pancreatic pseudocysts (PPs) present a challenging problem for physicians dealing with pancreatic disorders. Their management demands the co-operation of surgeons, radiologists and gastroenterologists. Historically, they have been treated either conservatively or surgically, with acceptable rates of complications and recurrence. However, recent advances in radiology and endoscopy, have leaded physicians to implement percutaneous and endoscopic drainage (ED) into their treatment algorithms. Moreover, laparoscopic surgery, with its advantages, has become an attractive alternative choice when surgical drainage (SD) is required...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682624/non-exposed-endoscopic-wall-inversion-surgery-for-gastrointestinal-stromal-tumor
#15
Takashi Mitsui, Hiroharu Yamashita, Susumu Aikou, Keiko Niimi, Mitsuhiro Fujishiro, Yasuyuki Seto
Laparoscopic and endoscopic cooperative surgery (LECS) is an accepted method of laparoscopic wedge resection, which is minimally invasive, for gastrointestinal stromal tumors (GISTs). We established a type of LECS achieving a full-thickness resection, non-exposed endoscopic wall-inversion surgery (NEWS), in an effort to prevent exposure of the peritoneal cavity to gastric intraluminal contents. We employed this surgical technique in 28 gastric GIST patients. We failed to complete NEWS in the initial two patients and in one patient with a large tumor (40 mm × 35 mm), but otherwise carried out the procedure successfully...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682623/long-term-adjuvant-treatment-of-gastrointestinal-stromal-tumors-gist-with-imatinib-a-comment-and-reflection-on-the-persist-5-study
#16
EDITORIAL
Silke Cameron
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682622/risk-of-hepatocellular-carcinoma-for-patients-treated-with-direct-acting-antivirals-steps-after-hepatitis-c-virus-eradication-to-achieve-elimination
#17
EDITORIAL
Mei-Hsuan Lee
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29682621/surgery-for-metastatic-gastrointestinal-stromal-tumor-to-whom-and-how-to
#18
REVIEW
Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Kinji Kamiya, Yoshifumi Morita, Takanori Sakaguchi, Hiroyuki Konno, Hiroya Takeuchi
Although imatinib is a standard treatment for metastatic or recurrent gastrointestinal stromal tumors (GISTs), acquired c-kit mutations reportedly cause secondary resistance to imatinib. Sunitinib is a tyrosine kinase inhibitor (TKI) that can be used as second-line therapy in imatinib-resistant or -intolerant GISTs. For sunitinib-resistant or -intolerant GISTs, regorafenib is a standard third-line treatment. Although TKI therapies have revolutionized the treatment of recurrent or metastatic GISTs, they cannot cure GISTs...
2018: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29552664/editorial-on-quality-standards-in-upper-gastrointestinal-endoscopy-a-position-statement-of-the-british-society-of-gastroenterology-bsg-and-association-of-upper-gastrointestinal-surgeons-of-great-britain-and-ireland-augis
#19
EDITORIAL
https://www.readbyqxmd.com/read/29552663/micromanagement-of-drug-resistant-advanced-gastrointestinal-stromal-tumors-regorafenib-new-ammunition-in-battling-exon-17-mutations
#20
EDITORIAL
Alexander J Eckardt, Ortwin Klein
No abstract text is available yet for this article.
2018: Translational Gastroenterology and Hepatology
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