Driele N Garcia, Jéssica D Hense, Bianka M Zanini, José V V Isola, Jorgea Pradiee, Juliane B Prosczek, Joao A Alvarado-Rincón, Rafael G Mondadori, Jeffrey B Mason, Miguel A Brieño-Enríquez, Carlos C Barros, Michael B Stout, Michal M Masternak, Augusto Schneider
Cellular senescence is a defense mechanism to arrest proliferation of damaged cells. The number of senescent cells increases with age in different tissues and contributes to the development of age-related diseases. Old mice treated with senolytics drugs, dasatinib and quercetin (D+Q), have reduced senescent cells burden. The aim of this study was to evaluate the effects of D+Q on testicular function and fertility of male mice. Mice (n = 9/group) received D (5 mg kg-1) and Q (50 mg kg-1) via gavage every moth for three consecutive days from 3 to 8 months of age...
May 26, 2023: Physiology International