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Physiology International

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https://www.readbyqxmd.com/read/29602295/moderate-hypothermia-and-responses-to-calcium-channel-blockers-role-of-the-nitric-oxide
#1
S Canbolat, K E Nurullahoglu Atalik
Moderate hypothermia (25-31 °C) may have a significant influence on vascular tone. At present, very little is known about the role of endothelial nitric oxide on the hypothermia-induced responses. In this study, we investigated the effect of hypothermia (to 28 °C) on the vasodilatation induced by verapamil, a phenylalkylamine calcium channel blocker (10-9 -3 × 10-4  M) and dihydropyridines, amlodipine (10-9 -3 × 10-4  M), and benidipine (10-9 -10-3  M) on 5-hydroxytryptamine (5-HT or serotonin) precontracted calf cardiac veins...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602294/melatonin-ameliorates-brain-oxidative-stress-and-upregulates-senescence-marker-protein-30-and-osteopontin-in-a-rat-model-of-vascular-dementia
#2
I Bin-Jaliah, H F Sakr
The aim of this study was to investigate the effect of melatonin on oxidative stress and senescence marker protein-30 (SMP30) as well as osteopontin (OPN) expression in the hippocampus of rats subjected to vascular dementia (VD). A total of 72 male rats were divided into six groups (n = 12 each) as follows: (i) untreated control (CON), (ii) sham-operated group, (iii) sham-operated + melatonin, (iv) rats exposed to VD induced by permanent bilateral occlusion of the common carotid arteries (BCCAO) leading to chronic cerebral hypoperfusion, (v) rats exposed to VD + melatonin, and (vi) rats exposed to VD + donepezil (DON)...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602293/swimming-exercise-demonstrates-advantages-over-running-exercise-in-reducing-proteinuria-and-glomerulosclerosis-in-spontaneously-hypertensive-rats
#3
N L Totou, S S Moura, D B Coelho, E C Oliveira, L K Becker, W G Lima
Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and were trained for 8 weeks under similar intensities (60 min/day)...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602292/heat-shock-proteins-and-cardiovascular-disease
#4
B Rodríguez-Iturbe, R J Johnson
The development of stress drives a host of biological responses that include the overproduction of a family of proteins named heat shock proteins (HSPs), because they were initially studied after heat exposure. HSPs are evolutionarily preserved proteins with a high degree of interspecies homology. HSPs are intracellular proteins that also have extracellular expression. The primary role of HSPs is to protect cell function by preventing irreversible protein damage and facilitating molecular traffic through intracellular pathways...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602291/surface-electromyographic-evaluation-of-the-neuromuscular-activation-of-the-inspiratory-muscles-during-progressively-increased-inspiratory-flow-under-inspiratory-resistive-loading
#5
H Sekiguchi, Y Tamaki, Y Kondo, H Nakamura, K Hanashiro, K Yonemoto, T Moritani, I Kukita
This study aimed to evaluate neuromuscular activation in the scalene and sternocleidomastoid muscles using surface electromyography (EMG) during progressively increased inspiratory flow, produced by increasing the respiratory rate under inspiratory-resistive loading using a mask ventilator. Moreover, we attempted to identify the EMG inflection point (EMGIP ) on the graph, at which the root mean square (RMS) of the EMG signal values of the inspiratory muscles against the inspiratory flow velocity acceleration abruptly increases, similarly to the EMG anaerobic threshold (EMGAT ) reported during incremental-resistive loading in other skeletal muscles...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602290/what-we-do-and-do-not-know-about-women-and-kidney-diseases-questions-unanswered-and-answers-unquestioned-reflection-on-world-kidney-day-and-international-woman-s-day
#6
G B Piccoli, M Alrukhaimi, Z-H Liu, E Zakharova, A Levin, World Kidney Day Steering Committee
Chronic kidney disease (CKD) affects approximately 10% of the world's adult population; it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29602289/effect-of-iloprost-on-contractile-impairment-and-mitochondrial-degeneration-in-ischemia-reperfusion-of-skeletal-muscle
#7
Z Bagis, M Ozeren, B Buyukakilli, E Balli, S Yaman, D Yetkin, D Ovla
Purpose Acute lower extremity ischemia is still a main cause of mortality and morbidity in orthopedic traumatology and reconstructive surgery. In acute lower extremity ischemia, the skeletal muscles are the tissues that are the most vulnerable to ischemia. The aim of this study was to evaluate the effects of iloprost (IL) therapy on skeletal muscle contractile impairment and mitochondrial degeneration in an acute lower extremity ischemia-reperfusion rat model. Main Methods Forty Wistar albino rats were randomly divided into a control group and four experimental groups...
March 1, 2018: Physiology International
https://www.readbyqxmd.com/read/29278029/biochemical-status-oxidative-and-antioxidant-responses-after-3-month-specific-training-in-elite-karate-athletes
#8
H Jemili, M A Mejri, E Bouhlel, M Amri
Aim To investigate the effects of 3-month-long specific training program on biochemical status, oxidative and antioxidant responses in elite karatekas. Methods Twenty male karatekas [BMI: 21.9 ± 2.4 (kg/m2 )] participated in this study. They performed a 3-month specific training to prepare for an international competition. We measured selected biochemical parameters, the oxidative and antioxidant responses before (T0) and after 3 months of intense karate training (T1). Results We found significant increases in catalase activity (26...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278028/post-transplantation-morphological-and-functional-changes-in-kidneys-from-expanded-criteria-donors
#9
B Borda, T Németh, A Ottlakan, C Keresztes, É Kemény, G Lázár
Introduction Despite an increase in the number of cadaver donors and overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors wanted to examine whether differences could exist in the function and/or morphology of transplanted kidneys originated from expanded criteria donors (ECDs) and ideal donors 1 and 5 years after transplantation. Methods Kidney function and histopathologic findings were analyzed and compared 1 and 5 years after transplantation in 97 patients having ECD kidneys and in 178 patients who received ideal donor kidneys (IDK)...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278027/environmental-enrichment-improved-cognitive-deficits-more-in-peri-adolescent-than-in-adult-rats-after-postnatal-monosodium-glutamate-treatment
#10
S Madhavadas, S Subramanian, B M Kutty
Exposure to enriched environment (EE) is known to promote sensory, cognitive, and motor stimulation with intensified levels of novelty and complexity. In this study, we investigated the positive regulatory effect of short-term exposure to EE on establishing functional recovery in monosodium glutamate (MSG)-induced obese rats. Unless treated, MSG rats exhibited peripheral insulin resistance, cognitive deficits, and a reduction in the total hippocampal volume with decreased neuron count in the DG, CA3, and CA1 subfields...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278026/the-effect-of-nasal-provocation-with-a-single-dose-allergen-on-the-physical-and-cognitive-performance-of-patients-with-ragweed-allergy
#11
M Tokodi, E Csábi, Á Kiricsi, E Kollár, A H Molnár, L Rovó, Z Bella
Purpose This study aims to compare the impact of active allergic rhinitis on physical and cognitive abilities of trained allergic athletes to untrained allergic patients. Methods Cognitive, respiratory, and fitness functions were assessed before and after allergen exposure. Participants in both groups were provoked intranasally with ragweed allergen. Results The group of athletes revealed significantly higher average values in peak inspiratory flow and fitness index before and after provocation. In neuropsychological assessments, athletes performed significantly better after allergen provocation in complex working memory capacity...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278025/the-influence-of-aging-on-the-effectiveness-of-heat-stress-in-preventing-disuse-muscle-atrophy
#12
H Kataoka, J Nakano, Y Kondo, Y Honda, J Sakamoto, T Origuchi, M Okita
This study examined the aging effect on disuse muscle atrophy prevention using heat stress. Wistar rats aged 7 and 60 weeks were divided into three groups as follows: control, immobilized (Im), and immobilized and heat stressed (ImH). Heat stress was given by immersing the hindlimbs in hot water (42 °C) for 60 min, once in every 3 days and the gastrocnemius (GAS) and soleus (SOL) muscles were extracted after 14 days. Muscle-fiber types were classified using ATPase staining. Heat shock protein 70 (HSP70) was assessed through Western blotting...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278024/curcumin-regulates-intracellular-calcium-release-and-inhibits-oxidative-stress-parameters-vegf-and-caspase-3-9-levels-in-human-retinal-pigment-epithelium-cells
#13
H Bardak, A C Uğuz, Y Bardak
In this study, we aimed to observe whether curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, a yellow substance obtained from the root of the plant Curcuma longa Linn, has any protective effect against blue light irradiation in human retinal pigment epithelium (ARPE-19) cells. For this purpose, we evaluated the intracellular calcium release mechanism, poly ADP ribose polymerase (PARP), procaspase-3/-9 protein expression levels, caspase activation, and reactive oxygen species levels...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29278023/effect-of-%C3%AE-tocopherol-megadoses-on-hematologic-parameters-and-antioxidant-capacity-of-rats-in-an-ultraendurance-probe
#14
V J Clemente-Suárez, J Mielgo-Ayuso, J L Quiles, A Varela-Lopez, P Aranda
This study was aimed to analyze the effect of two different megadoses of α-tocopherol (vit E) in the antioxidant activity and red and white blood series of Wistar rats after a 180-min ultraendurance probe. Three groups of 10 rats were analyzed; VEAG: acute administration of a megadoses of 5,000 IU/kg of vit E the day before the probe; VECG: chronic administration of 1,000 IU/kg/day of vit E for 6 days before the probe; CG: placebo administration. VEAG presented white cells, red blood cells, hematocrit, hemoglobin values significantly higher than CG and VECG (p < 0...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956642/erratum-to-impact-of-repeated-bouts-of-eccentric-exercise-on-sarcolemma-disruption-in-human-skeletal-muscle
#15
A Costa, Z Orosz, P Apor, N Csaba, S Siamilis, Z Csende, L Racz, J Tihanyi
No abstract text is available yet for this article.
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956641/vitamin-caused-faulty-perinatal-hormonal-imprinting-and-its-consequences-in-adult-age
#16
G Csaba
Lipid-soluble vitamins (vitamins A, D, E, and K) are actually hormones (exohormones), as they can be directly bound by hormone receptors or are in connection with molecules, which influence hormone receptors. Vitamin D is a transition between endo- and exohormones and the possibility of similar situation in case of other lipid-soluble hormones is discussed. The perinatal exposition with these "vitamins" can cause faulty perinatal hormonal imprinting with similar consequences as the faulty imprinting by the synthetic endohormones, members of the same hormone family or industrial, communal, or medical endocrine disruptors...
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956640/are-higher-blood-flow-restriction-pressures-more-beneficial-when-lower-loads-are-used
#17
S J Dankel, M B Jessee, S L Buckner, J G Mouser, K T Mattocks, J P Loenneke
The application of blood flow restriction during low-load resistance exercise has been shown to induce muscle growth with high or low restriction pressures, however, loads lower than 20% one-repetition maximum (1RM) remain unexplored. Fourteen trained individuals completed six elbow flexion protocols involving three different loads (10%, 15%, and 20% 1RM) each of which was performed with either a low (40% arterial occlusion) or high (80% arterial occlusion) pressure. Pre- and post-measurements of surface electromyography (sEMG), isometric torque, and muscle thickness were analyzed...
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956639/gender-may-have-an-influence-on-the-relationship-between-functional-movement-screen-scores-and-gait-parameters-in-elite-junior-athletes-a-pilot-study
#18
COMPARATIVE STUDY
N Magyari, V Szakács, C Bartha, B Szilágyi, K Galamb, M O Magyar, T Hortobágyi, R M Kiss, J Tihanyi, J Négyesi
Aims The aim of this study was to examine the effects of gender on the relationship between Functional Movement Screen (FMS) and treadmill-based gait parameters. Methods Twenty elite junior athletes (10 women and 10 men) performed the FMS tests and gait analysis at a fixed speed. Between-gender differences were calculated for the relationship between FMS test scores and gait parameters, such as foot rotation, step length, and length of gait line. Results Gender did not affect the relationship between FMS and treadmill-based gait parameters...
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956638/physiological-and-psychological-correlates-of-attention-related-body-sensations-tingling-and-warmth
#19
B T Tihanyi, F Köteles
Body sensations play an essential role in the subjective evaluation of our physical health, illness, and healing. They are impacted by peripheral somatic and external processes, but they are also heavily modulated by mental processes, e.g., attention, motor control, and emotion. Body sensations, such as tingling, numbness, pulse, and warmth, can emerge due to simply focusing attention on a body part. It is however an open question, if these sensations are connected with actual peripheral changes or happen "only in the mind...
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28956637/cilostazol-enhances-atorvastatin-induced-vasodilation-of-female-rat-aorta-during-aging
#20
K E Nurullahoğlu-Atalık, S Kutlu, H Solak, R Özen Koca
Statins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3-4 months (young) and 14-15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings...
September 1, 2017: Physiology International
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