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Advances in Respiratory Medicine

Olivier Moquet, Hakim Kherouf, Geoffroy de Faverges, Pierre Dumont, Evelyne Bourgerette, Tu N'Guyen
INTRODUCTION: We studied the characteristics of the screening procedure for alpha-1 antitrypsin at Nevers Hospital (France), together with the performance of serum protein gel electrophoresis for the fortuitous detection of patients with deficiency. MATERIAL AND METHODS: We carried out a retrospective study of requests for alpha-1 antitrypsin determination referred to the laboratory during 3 years. We compared these requests with the numbers of patients seen at the hospital and requiring screening according to international recommendations...
September 2, 2018: Advances in Respiratory Medicine
Teresa Grzelak, Klaudia Mikołajczyk
Cystic fibrosis - CF - is the most common recessively autosomally and inherited disorder in the Caucasian population. It is incurable, multi-systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is due to the fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure (caused by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food...
August 15, 2018: Advances in Respiratory Medicine
Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
The aim of the study was to find out scientific evidence on the possible use of the combined angiotensin II receptor antagonist and neprilysin inhibitors (ARNI) in patients with right heart failure (RHF) in the course of chronic obstructive pulmonary disease (COPD). It has been proven that a lack of neprilysin or its reduced expression in hypoxia leads to exacerbation of pulmonary arterial remodelling (PAR) or pulmonary hypertension (PH) in the mechanism related to the platelet-derived growth factor (PDGF) resulting in the proliferation and migration of pulmonary artery smooth muscle cells and endothelial-to-mesenchymal transition...
August 15, 2018: Advances in Respiratory Medicine
Magdalena Latos, Magdalena Ryba, Elżbieta Lazar, Marek Ochman
Hemorrhagic telangiectasia (HHT) is a disease of initially mild course - manifesting with recurrent nosebleeds and increased fatigue. Nevertheless, its progression can deteriorate patient's health. Solid organ transplantation becomes the only therapeutic option to save a life. Case series describes 19 years old female patient, who was diagnosed with HHT and qualified for lung transplantation. She meets Curacao criteria for HHT (¾). Her health deteriorated significantly to the point of the referral to Covered for Blind Review...
August 15, 2018: Advances in Respiratory Medicine
Małgorzata Dybowska, Monika Szturmowicz, Paweł Kuca, Barbara Kazanecka, Janusz Burakowski, Cezary Czajka, Franciszek Grzegorczyk, Renata Langfort, Barbara Burakowska, Piotr Rudziński, Witold Tomkowski
Background Neoplastic pericardial effusion (NPE) represents a common cause of morbidity and mortality in patient with cancer. NPE presents frequently as cardiac tamponade, requiring urgent pericardiocentesis or pericardiotomy, with subsequent pericardial fluid drainage. Despite high effectiveness of such procedures, the recurrence of effusion is noted in 30- 60% of patients. Intrapericardial therapy with cisplatin was found to be effective in NPE due to lung and breast cancer. Its role in cardiac tamponade due to renal cancer is unknown...
August 15, 2018: Advances in Respiratory Medicine
Rupali Malik, Ilavarasi Vanidassane, Neelima Jain
Background - Reduced lung function in diabetes has been described for long but its clinical importance is not yet clear. Also, limited literature is available regarding its association with sugar control, and its correlation with inflammatory markers. Thus, we aimed to study the pulmonary function test abnormalities and systemic inflammation in type 2 diabetes mellitus. Methods 100 patients of type 2 diabetes were divided into two groups depending on control of diabetes (group A-HbA1C≤7% and group B-HbA1C >7%)...
August 15, 2018: Advances in Respiratory Medicine
Mohammad Davoodi, Boshra Rezvankhah, Keivan Gohari Moghadam, Amir Pejman Hashemi Taheri
BACKGROUND AND AIMS: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease (e-COPD) is higher than in non-COPD states. This study aimed to evaluate the prevalence and the parameters that are critical for finding the incidence of PTE in patients with e-COPD. METHODS: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014...
August 15, 2018: Advances in Respiratory Medicine
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumeniuk, Tetiana Butova
The purpose of our study was to examine the efficacy and safety of intravenous chemotherapy during intensive treatment phase for patients with newly diagnosed pulmonary tuberculosis (pulmonary TB). MATERIALS AND METHODS: The study involved 92 patients with newly diagnosed pulmonary TB aged between 20 years and 68 years. All patient with newly diagnosed pulmonary TB and chemosensitive tuberculosis were enrolled in this study. The patients were allocated to two groups. The first (control) group of 46 patients received standard chemotherapy orally...
August 15, 2018: Advances in Respiratory Medicine
Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Eftychios Siniorakis, Spyridon Arvanitakis, Maximilianos Elkouris, Stamatia Kalogirou, Dimitrios Veldekis, Sotiria Limberi
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Marek Ochman, Maciej Urlik, Zofia Tatoj, Marta Wajda-Pokrontka, Fryderyk Zawadzki, Magdalena Latos, Marian Zembala
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by alteration of pulmonary veins. Many clinical and hemodynamic similarities to idiopathic pulmonary arterial hypertension (IPAH) may cause diagnostic and therapeutic difficulties. This case report is about a patient with PVOD, whose first symptoms of the disease occurred after infectious mononucleosis. Patient was administered with prostacycline (PGI2) mimetic (Treprostinil), what made qualification process and lung transplantation possible...
2018: Advances in Respiratory Medicine
Serafeim Chrysikos, Theodoros Karampitsakos, Argyrios Tzouvelekis, Katerina Dimakou
Endobronchial metastases (EBM) secondary to extrathoracic malignancies are very rare. Breast cancer, colorectal cancer and renal cell carcinoma represent the most common types of cancer leading to endobronchial metastases. They usually represent a late manifestation of other types of cancer and their prognosis is generally poor averaging a survival of 1-2 years in most case series. Due to their rarity, they remain a challenge for clinicians regarding whether they are primary lung tumors or not. This case report article intends to present a case of a young man with a left nephrectomy due to clear cell renal carcinoma, who developed EBM 7 years later and to summarize available data in the field...
2018: Advances in Respiratory Medicine
Aysun Isiklar, Sibel Ocak Serin, Antonio M Esquinas
There is a considerable variation in NIV among hospitals, regions and countries although it is a simple and useful method. The patient should be monitored via subjective response (respiratory distress, consciousness, problems related to mask and airflow), physiological responses (respiration rate, respiratory effort, air leakage) and patient-ventilator compliance (gas exchange, pulse oximetry, arterial blood gases). Normalization in respiration rate within 1 or 2 hours after initiation of treatment is one of the most important markers for recovery...
2018: Advances in Respiratory Medicine
Wojciech Jerzy Piotrowski, Prof Paweł P Liberski Jerzy Żądło, Witold Górski, Anna Kumor-Kisielewska, Marek Fijałkowski, Zofia Kurmanowska, Jerzy Marczak, Łukasz Gwadera, Wojciech Angowski, Paweł Górski, Sylwia Kwiatkowska
INTRODUCTION: Sarcoidosis and tuberculosis (TB) are the diseases that share many similarities. Mycobacterium tuberculosis (MTB) culture results are the gold standard for the diagnosis of TB, but false positive results are not rare. The aim was to evaluate the utility of QFT in detecting latent TB infection in a group of sarcoidosis patients with negative history of TB and negative culture/BACTEC results, and checking sarcoidosis activity influence on the QFT results. Additionally, we assessed if QFT negative result may strengthen the suspicion that positive culture/BACTEC results are false positive...
2018: Advances in Respiratory Medicine
Michał Zieliński, Mariusz Gąsior, Dariusz Jastrzębski, Aneta Desperak, Dariusz Ziora
INTRODUCTION: Particulate matter air pollution constitutes an important factor affecting the course of various respiratory and cardiovascular diseases. Two main monitored groups of particulate pollution are particulate matter with the aerodynamic diameter below 10 μm (PM10) and 2.5 μm (PM2.5). One of the most important respiratory diseases is chronic obstructive pulmonary disease (COPD). Clinical presentation of COPD and cardiovascular diseases is similar and can cause complications during therapy...
2018: Advances in Respiratory Medicine
Daria Magdalena Springer, Szczepan Cofta, Robert Juszkat, Bartosz Żabicki, Joanna Goździk-Spychalska, Agata Nowicka, Hanna Winiarska, Halina Batura-Gabryel
INTRODUCTION: Bronchial artery embolisation (BAE) is one of the methods used in massive and recurring haemoptysis. The aim of the study is to determine the effectiveness and complications of bronchial artery embolisation in recurring haemoptysis. MATERIAL AND METHODS: The analysis included 47 embolisation procedures performed on 30 patients treated between 2011 and 2017 in the Department of Respiratory Medicine, Allergology and Pulmonary Oncology due to haemoptysis...
2018: Advances in Respiratory Medicine
Armin Krvavac, Kurt Munzer, Aaron Miller, Nishant Poddar, Zafar Jamkhana, Setu Patolia
INTRODUCTION: Granulomatous inflammation has been associated with malignancies such as breast, testicular, renal cell, and lymphoma. The coexistence of granulomatous inflammation in mediastinal/hilar lymph node with primary lung malignancy has been described in case reports. Our goal was to examine the frequency of granulomatous reaction in mediastinal/hilar lymph node in the patients who had undergone surgical resection of lung cancer. MATERIAL AND METHODS: We performed a retrospective analysis of 40 patients (1) aged ≥ 18 years and (2) who underwent lobectomy or pneumonectomy from August 1, 2012 to October 31, 2016 at Saint Louis University Hospital and (3) had pathology suggestive of cancer...
2018: Advances in Respiratory Medicine
Manju Rajaram, Adimulam Ganga Ravindra, Dharm Prakash Dwivedi, Jayalakshmi Ramakrishnan, Palanivel Chinnakali, Madhusmita Mohanty Mohapatra
INTRODUCTION: In India, to increase human immunodeficiency virus (HIV) case detection, the National Technical Working Group on TB /HIV had made it mandatory to screen for HIV infection among presumptive tuberculosis (TB) cases. MATERIAL AND METHODS: Our study was a cross-sectional study, conducted between June 2015 and December 2016 in a tertiary care institute (JIPMER), in South India, to estimate the prevalence of HIV among presumptive TB cases. RESULTS: Among the 964 presumptive TB cases who attended pulmonary medicine OPD, 189 patients were sputum acid-fast bacilli (AFB) positive...
2018: Advances in Respiratory Medicine
Anushree Chakraborthy, Akshata Jayachamarajapura Shivananjaiah, Swapna Ramaswamy, Nagaraja Chikkavenkatappa
INTRODUCTION: Chest X-ray (CXR) has been used since long as an aid in the diagnosis of pulmonary tuberculosis (PTB) and also to determine the extent of the disease. The present study was conducted to evaluate the correlation of disease extent on CXR basing on the Timika CXR score with clinical and microbiological parameters at baseline, in sputum positive cases of pulmonary tuberculosis. MATERIAL AND METHODS: The study was conducted at a tertiary referral centre for chest diseases in Bangalore, Karnataka from January 2017 to January 2018...
2018: Advances in Respiratory Medicine
Teresa Bielecka, Ewa Augustynowicz-Kopeć, Paweł Gonerko, Paweł Gruszczyński, Maria Korzeniewska-Koseła, Maria Krasińska, Katarzyna Krenke, Joanna Lange, Anna Pankowska, Marek Popielarz, Andrzej Pustkowski, Joanna Stryczyńska-Kazubska, Zbigniew Doniec
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe hematogenous forms of tuberculosis, vaccination lowers the risk of infection with Mycobacterium tuberculosis. Primary and acquired immunodeficiency, including immunity disorders associated with an ongoing treatment, are contraindications to BCG vaccination...
2018: Advances in Respiratory Medicine
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