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Advances in Respiratory Medicine

Teresa Bielecka, Ewa Augustynowicz-Kopeć, Paweł Gonerko, Paweł Gruszczyński, Maria Korzeniewska-Koseła, Maria Krasińska, Katarzyna Krenke, Joanna Lange, Anna Pankowska, Marek Popielarz, Andrzej Pustkowski, Joanna Stryczyńska-Kazubska, Zbigniew Doniec
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe hematogenous forms of tuberculosis, vaccination lowers the risk of infection with Mycobacterium tuberculosis. Primary and acquired immunodeficiency, including immunity disorders associated with an ongoing treatment, are contraindications to BCG vaccination...
2018: Advances in Respiratory Medicine
Joanna Domagała-Kulawik
Immunotherapy with immune checkpoint inhibitors (ICIs) revolutionized therapy of solid tumors, among them- lung cancer. PD-1, PD-L1 blockers have been shown to improve overall survival in advanced, metastatic non-small cell lung cancer. In individual patients, 3-5-year survival has been achieved. Nivolumab, pembrolizumab, atezolizumab are approved in lung cancer treatment. Practical observations in reallife show that the results are comparable with those achieved in clinical trials. The effects of ICIs depend on the patient performance status; age, sex, histology; the presence of brain metastases have not modified treatment results...
2018: Advances in Respiratory Medicine
Monika Szturmowicz, Aneta Kacprzak, Małgorzata Szołkowska, Barbara Burakowska, Ewa Szczepulska, Jan Kuś
Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) are rare disorders, with the estimated prevalence of less than 1 case per million inhabitants. The vascular pathology in PVOD/PCH involves pre-septal and septal veins, alveolar capillaries and small pulmonary arteries. According to the ERS/ESC classification of pulmonary hypertension (PH) from 2015, PVOD/PCH have been included in the subgroup 1' of pulmonary arterial hypertension (PAH). Recent data indicate, however, the possibility of PVOD/PCH pathology in the patients diagnosed in the group 1...
2018: Advances in Respiratory Medicine
Piotr Janowiak, Alicja Siemińska, Maria Porzezińska, Żaneta Smoleńska, Hanna Suchanek, Ewa Jassem
Pulmonary embolism is the most common pulmonary manifestation of primary antiphospholipid syndrome (PAPS). However, PAPS may manifest in the respiratory system also due to non-thrombotic processes. In the following paper we present a case of PAPS-related diffuse alveolar hemorrhage (DAH). Because of sparse literature and a lack of randomized controlled trials, there are currently no recommendations regarding the optimal choice of steroid-sparing agent in treating PAPS-related DAH. In our patient, treatment with cyclophosphamide or mycophenolate mofetil along with low dose prednisone was ineffective, partially because of infectious complications, whereas addition of monthly intravenous immunoglobulin to mycophenolate mofetil and prednisone, appears to control the disease...
2018: Advances in Respiratory Medicine
Marcin Skowroński, Anna Halicka, Aleksander Barinow-Wojewódzki
Silicosis, a preventable occupational lung disease, is associated with various diseases, including tuberculosis (TB). There is an increased lifelong risk for lung tuberculosis even if exposure to silica dust ceases. That association contributes in a large extent to very high rates of tuberculosis in countries with poor TB and silica exposure control. We report a case of a male with a prior diagnosis of silicosis who was diagnosed with and treated for TB. Anti-tuberculous treatment was extended due to a positive sputum smear in the six th month of treatment...
2018: Advances in Respiratory Medicine
Olga Truba, Aleksandra Rybka, Karolina Klimowicz, Elżbieta Magdalena Grabczak, Małgorzata Żukowska, Marta Dąbrowska, Rafał Krenke
INTRODUCTION: There are few original studies on the true role of normal chest radiograph (CXR) in exclusion of pulmonary conditions that may be associated with chronic cough. Thus, the aim of the study was to assess whether a plain CXR is a sufficient tool to exclude relevant pulmonary causes of chronic cough. MATERIAL AND METHODS: A retrospective analysis of chest computed tomography (CT) scans in non-smoking patients with chronic cough and normal CXR was performed...
2018: Advances in Respiratory Medicine
Justyna Maria Torbiarczyk, Patryk Aleksander Sobczak, Katarzyna Krystyna Torbiarczyk, Joanna Miłkowska-Dymanowska, Adam Antczak, Paweł Górski, Adam J Białas, Wojciech Jerzy Piotrowski
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Tomohiro Tamura, Toshihiro Shiozawa, Kunihiko Miyazaki Kunihiko Miyazaki, Hiroaki Satoh
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Izabela Szymczak, Rafal Pawliczak
Asthma - a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients...
2018: Advances in Respiratory Medicine
Ioannis Tomos, Nikos Tziolos, Thomas Raptakis, Dimitra Kavatha
Transthoracic ultrasound has lately emerged as a useful diagnostic tool for respiratory physicians in the diagnosis of diverse pulmonary diseases, usually including pleural effusion and pneumothorax. However, the use of chest ultrasound may be also critical in the evaluation of chest wall diseases. Therefore, we present an interesting case of a patient with metastases of lung cancer to the rib, detected during the chest wall ultrasound examination. By representing a non-invasive, surface-imaging technique with several advantages, chest ultrasound may evolve to a valid, bed-side diagnostic tool for the diagnosis and follow up of lung cancer with metastases in the chest wall...
2018: Advances in Respiratory Medicine
Vasiliki Apollonatou, Stelios Loukides, Andriana I Papaioannou, Spyros Papiris
We are presenting a case of acrometastasis in a male patient with lung adenocarcinoma. Acrometastases accumulate for 0.1% of all metastatic bone lesions and can be the first manifestation of cancer in approximately 10% of cases. The main clinical manifestations are tenderness, intermittent pain, functional impairment, erythema, heat and swelling of the affected part. Lung cancer is the main primary malignancy which causes acrometastases. Although the lesions can be recognized in x-rays or CT scans, the gold standard for the diagnosis is MRI scan in which the full extension of the tumor can be evaluated...
2018: Advances in Respiratory Medicine
Justyna Fijołek, Elżbieta Wiatr, Małgorzata Polubiec-Kownacka, Katarzyna Błasińska-Przerwa, Małgorzata Szołkowska, Ewa Szczepulska-Wójcik, Kazimierz Roszkowski-Śliż
Differentiation between pulmonary tuberculosis and lung cancer is often challenging for clinicians, especially that both conditions can coexist. This is due to the fact that the clinical and radiological symptoms of both diseases can be similar. Our case report presents a patient who was treated for advanced lung cancer 10 years earlier and currently has been hospitalized again because of a strong clinical and radiological suspicion of the cancer progression, but whose final diagnosis was tuberculosis.
2018: Advances in Respiratory Medicine
Renata Zubrzycka
INTRODUCTION: Studies of coping with stress of parents of children with cystic fibrosis (CF) are relatively rare and their results are inconsistent. The aim of the work was to determine the strategies of coping with stress of Polish mothers of children and adolescents with CF. MATERIAL AND METHODS: The research was conducted in the group of 89 Polish mothers of children with CF (0-18) and used the Brief COPE by Carver in the Polish adaptation by Juczyński and Ogińska-Bulik (2009)...
2018: Advances in Respiratory Medicine
Grzegorz Gawron, Marzena Trzaska-Sobczak, Ewa Sozańska, Piotr Śnieżek, Adam Barczyk
INTRODUCTION: The aim of the study was to measure the concentrations of vitamin D in serum of COPD patients with chronic respiratory failure in comparison to healthy control group. The correlation between the levels of vitamin D in serum and the selected clinical, spirometric and blood gas parameters was the additional aim of the study. MATERIAL AND METHODS: The study included 61 patients with diagnosed COPD in stadium of chronic respiratory failure (45 men and 16 women) and 37 healthy controls (19 men and 18 women)...
2018: Advances in Respiratory Medicine
Kshitij Chatterjee, Abhinav Goyal, Deepak Reddy, Vikas Koppurapu, Ayoub Innabi, Bashar Alzghoul, Rajani Jagana
INTRODUCTION: Patients with Cystic Fibrosis (CF) have increasing rates of hospitalization. We analyzed the burden and predictors of thirty-day readmission among patients with CF in the U.S. MATERIAL AND METHODS: Nationwide Readmission Database (NRD) 2013 was used to identify adults with CF who were hospitalized. These individuals were followed to determine the prevalence of readmission within thirty days of index discharge. Cox proportional hazard regression was used to identify independent predictors of readmission...
2018: Advances in Respiratory Medicine
Witold Rzyman, Joanna Didkowska, Robert Dziedzic, Tomasz Grodzki, Tadeusz Orłowski, Edyta Szurowska, Renata Langfort, Wojciech Biernat, Dariusz Kowalski, Wojciech Dyszkiewicz, Tadeusz Jędrzejczyk, Tomasz Zdrojewski, Sergiusz Nawrocki, Ewa Jassem, Mariusz Adamek
INTRODUCTION: Lung cancer is the most common cancer in Poland and worldwide, and the leading cause of cancer-related deaths. Compared to the present day, the annual number of new cases of lung cancer will have increased by approximately 50%, by 2030. The overall ratio of mortality to incidence totals 0.87 and is among the highest. The five-year survival rate in Poland has recently achieved 13.4%. In 2015, lung cancer screening using low-dose computed tomography (LDCT) was introduced to routine clinical practice in the United States following the publication of the largest randomised study, The National Lung Screening Trial...
2018: Advances in Respiratory Medicine
Andrzej Emeryk, M Pirożyński, J Emeryk-Maksymiuk
The article briefly presents currently accessible dry powder inhalers (DPI). Basing on the data from the literature, we discussed the most common mistakes related to the utilisation of DPI as well as their clinical and economic consequences. We also extensively analysed all factors that may influence the efficacy and safety of inhaler therapy of asthma and COPD, mostly with the use of DPI. In addition, we indicated the potential to improve the efficacy of inhaler therapy from the doctor and COPD or asthma patient perspective...
2018: Advances in Respiratory Medicine
Sofoklis Mitsos, Alexandros Stamatopoulos, Davide Patrini, Robert S George, David R Lawrence, Nikolaos Panagiotopoulos
INTRODUCTION: Castleman's disease is a rare benign lymphoproliferative disorder of unknown etiology. The disease occurs in two clinical forms with different prognoses, treatments and symptoms: a unicentric form (UCD), which is solitary, localized, and a multicentric form characterized by generalized lymphadenopathy and systemic symptoms. This article aims to review the current literature to consolidate the evidence surrounding the curative potential of surgical treatment to the unicentric type...
2018: Advances in Respiratory Medicine
Akshay Khatri, Abhinav Agrawal, Rutuja R Sikachi, Dhruv Mehta, Sonu Sahni, Nikhil Meena
Inflammatory myofibroblastic tumors (IMT) of the lung, first reported in 1939, are considered a subset of inflammatory pseudo -tumors. They are a distinctive lesions composed of myofibroblastic spindle cells accompanied by an inflammatory infiltrate of plasma cells, lymphocytes, and eosinophils. IMTs may be benign, invade surrounding structures, undergo malignant transformation, recur or may even metastasize. They can occur due to a genetic mutation or can occur secondary to infectious or autoimmune diseases...
2018: Advances in Respiratory Medicine
Dorota Wyrostkiewicz, Monika Szturmowicz, Iwona Bartoszuk, Izabela Siemion-Szcześniak, Lilia Jakubowska, Ewa Augustynowicz-Kopeć, Jan Kuś
Mycobacterial lung disease is caused by nontuberculous mycobacteria (NTM), also known as atypical mycobacteria. NTM are widely distributed in the environment, particularly in soil and water; they may colonize the airways, gastrointestinal tract and genitourinary system, without the apparent signs of disease. Nevertheless, in some risk groups such as patients with chronic lung diseases or with immunodeficiency, mycobacterial lung disease is identified. Recently, increased recognition of mycobacterial lung disease in chronic obstructive pulmonary disease (COPD) patients has been observed, especially in those treated with high doses of inhaled corticosteroids...
2018: Advances in Respiratory Medicine
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