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Advances in Respiratory Medicine

Olivier Moquet, Hakim Kherouf, Geoffroy de Faverges, Pierre Dumont, Evelyne Bourgerette, Tu N'Guyen
INTRODUCTION: We studied the characteristics of the screening procedure for alpha-1 antitrypsin at Nevers Hospital (France), together with the performance of serum protein gel electrophoresis for the fortuitous detection of patients with deficiency. MATERIAL AND METHODS: We carried out a retrospective study of requests for alpha-1 antitrypsin determination referred to the laboratory during 3 years. We compared these requests with the numbers of patients seen at the hospital and requiring screening according to international recommendations...
September 2, 2018: Advances in Respiratory Medicine
Teresa Grzelak, Klaudia Mikołajczyk
Cystic fibrosis - CF - is the most common recessively autosomally and inherited disorder in the Caucasian population. It is incurable, multi-systemic disease with progressive course. CF is caused by CFTR gene mutation, the product of which is Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). CF patients are exposed to fat-soluble vitamins deficiency, including vitamin D. It is due to the fat malabsorption (caused by exacerbation exocrine pancreatic insufficiency), decreased sun exposure (caused by receiving antibiotics photophobia), reduction of adipose tissue and insufficient supply with food...
August 15, 2018: Advances in Respiratory Medicine
Maciej Liczek, Iga Panek, Piotr Damiański, Olga Jęczeń, Jędrzej Jaźwiec, Piotr Kuna, Michał Panek
The aim of the study was to find out scientific evidence on the possible use of the combined angiotensin II receptor antagonist and neprilysin inhibitors (ARNI) in patients with right heart failure (RHF) in the course of chronic obstructive pulmonary disease (COPD). It has been proven that a lack of neprilysin or its reduced expression in hypoxia leads to exacerbation of pulmonary arterial remodelling (PAR) or pulmonary hypertension (PH) in the mechanism related to the platelet-derived growth factor (PDGF) resulting in the proliferation and migration of pulmonary artery smooth muscle cells and endothelial-to-mesenchymal transition...
August 15, 2018: Advances in Respiratory Medicine
Magdalena Latos, Magdalena Ryba, Elżbieta Lazar, Marek Ochman
Hemorrhagic telangiectasia (HHT) is a disease of initially mild course - manifesting with recurrent nosebleeds and increased fatigue. Nevertheless, its progression can deteriorate patient's health. Solid organ transplantation becomes the only therapeutic option to save a life. Case series describes 19 years old female patient, who was diagnosed with HHT and qualified for lung transplantation. She meets Curacao criteria for HHT (¾). Her health deteriorated significantly to the point of the referral to Covered for Blind Review...
August 15, 2018: Advances in Respiratory Medicine
Małgorzata Dybowska, Monika Szturmowicz, Paweł Kuca, Barbara Kazanecka, Janusz Burakowski, Cezary Czajka, Franciszek Grzegorczyk, Renata Langfort, Barbara Burakowska, Piotr Rudziński, Witold Tomkowski
Background Neoplastic pericardial effusion (NPE) represents a common cause of morbidity and mortality in patient with cancer. NPE presents frequently as cardiac tamponade, requiring urgent pericardiocentesis or pericardiotomy, with subsequent pericardial fluid drainage. Despite high effectiveness of such procedures, the recurrence of effusion is noted in 30- 60% of patients. Intrapericardial therapy with cisplatin was found to be effective in NPE due to lung and breast cancer. Its role in cardiac tamponade due to renal cancer is unknown...
August 15, 2018: Advances in Respiratory Medicine
Rupali Malik, Ilavarasi Vanidassane, Neelima Jain
Background - Reduced lung function in diabetes has been described for long but its clinical importance is not yet clear. Also, limited literature is available regarding its association with sugar control, and its correlation with inflammatory markers. Thus, we aimed to study the pulmonary function test abnormalities and systemic inflammation in type 2 diabetes mellitus. Methods 100 patients of type 2 diabetes were divided into two groups depending on control of diabetes (group A-HbA1C≤7% and group B-HbA1C >7%)...
August 15, 2018: Advances in Respiratory Medicine
Mohammad Davoodi, Boshra Rezvankhah, Keivan Gohari Moghadam, Amir Pejman Hashemi Taheri
BACKGROUND AND AIMS: The risk of pulmonary thromboembolism (PTE) in patients with exacerbated chronic obstructive pulmonary disease (e-COPD) is higher than in non-COPD states. This study aimed to evaluate the prevalence and the parameters that are critical for finding the incidence of PTE in patients with e-COPD. METHODS: This cross-sectional study was performed on 68 consecutive patients with the e-COPD, referred to the Pulmonary Disease Department at the Shariati Hospital in Tehran between 2013 and 2014...
August 15, 2018: Advances in Respiratory Medicine
Dmytro Butov, Yurii Feshchenko, Mykhailo Kuzhko, Mykola Gumeniuk, Tetiana Butova
The purpose of our study was to examine the efficacy and safety of intravenous chemotherapy during intensive treatment phase for patients with newly diagnosed pulmonary tuberculosis (pulmonary TB). MATERIALS AND METHODS: The study involved 92 patients with newly diagnosed pulmonary TB aged between 20 years and 68 years. All patient with newly diagnosed pulmonary TB and chemosensitive tuberculosis were enrolled in this study. The patients were allocated to two groups. The first (control) group of 46 patients received standard chemotherapy orally...
August 15, 2018: Advances in Respiratory Medicine
Teresa Bielecka, Ewa Augustynowicz-Kopeć, Paweł Gonerko, Paweł Gruszczyński, Maria Korzeniewska-Koseła, Maria Krasińska, Katarzyna Krenke, Joanna Lange, Anna Pankowska, Marek Popielarz, Andrzej Pustkowski, Joanna Stryczyńska-Kazubska, Zbigniew Doniec
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe hematogenous forms of tuberculosis, vaccination lowers the risk of infection with Mycobacterium tuberculosis. Primary and acquired immunodeficiency, including immunity disorders associated with an ongoing treatment, are contraindications to BCG vaccination...
2018: Advances in Respiratory Medicine
Joanna Domagała-Kulawik
Immunotherapy with immune checkpoint inhibitors (ICIs) revolutionized therapy of solid tumors, among them- lung cancer. PD-1, PD-L1 blockers have been shown to improve overall survival in advanced, metastatic non-small cell lung cancer. In individual patients, 3-5-year survival has been achieved. Nivolumab, pembrolizumab, atezolizumab are approved in lung cancer treatment. Practical observations in reallife show that the results are comparable with those achieved in clinical trials. The effects of ICIs depend on the patient performance status; age, sex, histology; the presence of brain metastases have not modified treatment results...
2018: Advances in Respiratory Medicine
Monika Szturmowicz, Aneta Kacprzak, Małgorzata Szołkowska, Barbara Burakowska, Ewa Szczepulska, Jan Kuś
Pulmonary veno-occlusive disease (PVOD) and pulmonary capillary haemangiomatosis (PCH) are rare disorders, with the estimated prevalence of less than 1 case per million inhabitants. The vascular pathology in PVOD/PCH involves pre-septal and septal veins, alveolar capillaries and small pulmonary arteries. According to the ERS/ESC classification of pulmonary hypertension (PH) from 2015, PVOD/PCH have been included in the subgroup 1' of pulmonary arterial hypertension (PAH). Recent data indicate, however, the possibility of PVOD/PCH pathology in the patients diagnosed in the group 1...
2018: Advances in Respiratory Medicine
Piotr Janowiak, Alicja Siemińska, Maria Porzezińska, Żaneta Smoleńska, Hanna Suchanek, Ewa Jassem
Pulmonary embolism is the most common pulmonary manifestation of primary antiphospholipid syndrome (PAPS). However, PAPS may manifest in the respiratory system also due to non-thrombotic processes. In the following paper we present a case of PAPS-related diffuse alveolar hemorrhage (DAH). Because of sparse literature and a lack of randomized controlled trials, there are currently no recommendations regarding the optimal choice of steroid-sparing agent in treating PAPS-related DAH. In our patient, treatment with cyclophosphamide or mycophenolate mofetil along with low dose prednisone was ineffective, partially because of infectious complications, whereas addition of monthly intravenous immunoglobulin to mycophenolate mofetil and prednisone, appears to control the disease...
2018: Advances in Respiratory Medicine
Marcin Skowroński, Anna Halicka, Aleksander Barinow-Wojewódzki
Silicosis, a preventable occupational lung disease, is associated with various diseases, including tuberculosis (TB). There is an increased lifelong risk for lung tuberculosis even if exposure to silica dust ceases. That association contributes in a large extent to very high rates of tuberculosis in countries with poor TB and silica exposure control. We report a case of a male with a prior diagnosis of silicosis who was diagnosed with and treated for TB. Anti-tuberculous treatment was extended due to a positive sputum smear in the six th month of treatment...
2018: Advances in Respiratory Medicine
Olga Truba, Aleksandra Rybka, Karolina Klimowicz, Elżbieta Magdalena Grabczak, Małgorzata Żukowska, Marta Dąbrowska, Rafał Krenke
INTRODUCTION: There are few original studies on the true role of normal chest radiograph (CXR) in exclusion of pulmonary conditions that may be associated with chronic cough. Thus, the aim of the study was to assess whether a plain CXR is a sufficient tool to exclude relevant pulmonary causes of chronic cough. MATERIAL AND METHODS: A retrospective analysis of chest computed tomography (CT) scans in non-smoking patients with chronic cough and normal CXR was performed...
2018: Advances in Respiratory Medicine
Justyna Maria Torbiarczyk, Patryk Aleksander Sobczak, Katarzyna Krystyna Torbiarczyk, Joanna Miłkowska-Dymanowska, Adam Antczak, Paweł Górski, Adam J Białas, Wojciech Jerzy Piotrowski
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Tomohiro Tamura, Toshihiro Shiozawa, Kunihiko Miyazaki Kunihiko Miyazaki, Hiroaki Satoh
No abstract text is available yet for this article.
2018: Advances in Respiratory Medicine
Izabela Szymczak, Rafal Pawliczak
Asthma - a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients...
2018: Advances in Respiratory Medicine
Ioannis Tomos, Nikos Tziolos, Thomas Raptakis, Dimitra Kavatha
Transthoracic ultrasound has lately emerged as a useful diagnostic tool for respiratory physicians in the diagnosis of diverse pulmonary diseases, usually including pleural effusion and pneumothorax. However, the use of chest ultrasound may be also critical in the evaluation of chest wall diseases. Therefore, we present an interesting case of a patient with metastases of lung cancer to the rib, detected during the chest wall ultrasound examination. By representing a non-invasive, surface-imaging technique with several advantages, chest ultrasound may evolve to a valid, bed-side diagnostic tool for the diagnosis and follow up of lung cancer with metastases in the chest wall...
2018: Advances in Respiratory Medicine
Vasiliki Apollonatou, Stelios Loukides, Andriana I Papaioannou, Spyros Papiris
We are presenting a case of acrometastasis in a male patient with lung adenocarcinoma. Acrometastases accumulate for 0.1% of all metastatic bone lesions and can be the first manifestation of cancer in approximately 10% of cases. The main clinical manifestations are tenderness, intermittent pain, functional impairment, erythema, heat and swelling of the affected part. Lung cancer is the main primary malignancy which causes acrometastases. Although the lesions can be recognized in x-rays or CT scans, the gold standard for the diagnosis is MRI scan in which the full extension of the tumor can be evaluated...
2018: Advances in Respiratory Medicine
Justyna Fijołek, Elżbieta Wiatr, Małgorzata Polubiec-Kownacka, Katarzyna Błasińska-Przerwa, Małgorzata Szołkowska, Ewa Szczepulska-Wójcik, Kazimierz Roszkowski-Śliż
Differentiation between pulmonary tuberculosis and lung cancer is often challenging for clinicians, especially that both conditions can coexist. This is due to the fact that the clinical and radiological symptoms of both diseases can be similar. Our case report presents a patient who was treated for advanced lung cancer 10 years earlier and currently has been hospitalized again because of a strong clinical and radiological suspicion of the cancer progression, but whose final diagnosis was tuberculosis.
2018: Advances in Respiratory Medicine
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