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Journal of Translational Internal Medicine

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https://www.readbyqxmd.com/read/29607306/resistin-levels-in-non-alcoholic-fatty-liver-disease-pathogenesis
#1
Carmela Colica, Ludovico Abenavoli
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607305/gastric-antral-vascular-ectasia-a-case-report-and-literature-review
#2
Abdulrahman M Alkhormi, Muhammed Yousuf Memon, Abdullah Alqarawi
Gastric antral vascular ectasia (GAVE) is a rare but an important cause of upper gastrointestinal bleeding (UGIB) and commonly presents as occult bleeding that manifests as iron deficiency anemia (IDA). GAVE is commonly associated with chronic illnesses, most frequently liver cirrhosis and connective tissue diseases. The pathogenesis of GAVE is still obscure, and many hypotheses such as mechanical stress, hormonal factors, and autoimmune factors, have been proposed. Upper gastrointestinal endoscopy has a major role in the diagnosis and treatment of GAVE...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607304/neutrophil-to-lymphocyte-ratio-relation-to-sepsis-severity-scores-and-inflammatory-biomarkers-in-patients-with-community-acquired-pneumonia-a-case-series
#3
Nikolaos-Dimitrios Pantzaris, Christina Platanaki, Charalampos Pierrako, Vasilios Karamouzos, Dimitrios Velissaris
Background and Objectives: Neutrophil to lymphocyte ratio (NLR) as calculated from the white cell differential blood count is considered a promising marker for the prognosis of patients with various diseases, including sepsis. This study was designed to assess the possible use of neutrophil-to-lymphocyte ratio in the prediction of survival outcomes in patients with community acquired pneumonia (CAP). A secondary objective was to compare the prognostic accuracy of NLR with the commonly used severity scores of sepsis SOFA, APACHE II and SAPS II...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607303/diagnostic-accuracy-of-aspartate-aminotransferase-to-platelet-ratio-index-and-fibrosis-4-scores-in-predicting-advanced-liver-fibrosis-in-patients-with-end-stage-renal-disease-and-chronic-viral-hepatitis-experience-from-pakistan
#4
Rajesh Kumar Wadhva, Muhammad Manzoorul Haque, Nasir Hassan Luck, Abbas Ali Tasneem, Zaigham Abbas, Muhammad Mubarak
Objectives: The aim was to assess the diagnostic accuracy of APRI and FIB-4 in assessing the stage of liver fibrosis in end stage renal disease (ESRD) patients with chronic viral hepatitis and to compare the two tests with standard tru-cut liver biopsy. Material and Methods: The study was conducted at Sindh Institute of Urology and Transplantation Karachi (SIUT) from May 2010 to May 2014. All ESRD patients, being considered as candidates for renal transplantation and in whom liver biopsy was performed were included...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607302/predisposing-factors-for-chemotherapy-induced-nephrotoxicity-in-patients-with-advanced-esophageal-cancer-who-received-combination-chemotherapy-with-docetaxel-cisplatin-and-5-fluorouracil
#5
Junichi Mohri, Chikatoshi Katada, Marie Ueda, Mitsuhiro Sugawara, Keishi Yamashita, Hiromitsu Moriya, Shouko Komori, Kazushige Hayakawa, Wasaburo Koizumi, Koichiro Atsuda
Background and Objectives: We retrospectively studied the predisposing factors for nephrotoxicity in the patients with advanced esophageal squamous-cell carcinoma who received combination chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF therapy). Methods: Between January 2010 and March 2014, 41 patients with Stage IB to III esophageal squamous-cell carcinoma received the DCF therapy (docetaxel 70-75 mg/m2 , day 1; cisplatin 70-75 mg/m2 , day 1; 5-fluorouracil 750 mg/m2 , days 1-5) in our hospital...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607301/contemporary-situation-of-community-acquired-pneumonia-in-china-a-systematic-review
#6
Ying-Gang Zhu, Xiao-Dan Tang, Yun-Tao Lu, Jing Zhang, Jie-Ming Qu
The prevalence and microbial pattern reported for Community-acquired pneumonia (CAP) differ considerably and contemporary situation remains changing over time. We therefore searched both international and domestic databases for relevant references and pooled incidence of CAP and etiological distribution were estimated separately between children and adults groups. The results showed that CAP remained a major public health issue in China, with a relatively higher incidence than that reported in Western countries...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607300/do-statins-induce-or-protect-from-acute-kidney-injury-and-chronic-kidney-disease-an-update-review-in-2018
#7
An Verdoodt, Patrick M Honore, Rita Jacobs, Elisabeth De Waele, Viola Van Gorp, Jouke De Regt, Herbert D Spapen
Statins essentially are cholesterol-lowering drugs that are extensively prescribed for primary and secondary prevention of cardiovascular disease. Compelling evidence suggests that the beneficial effects of statins may not only be due to its ability to control cholesterol levels but also due to a pleiotropic cholesterol-independent anti-inflammatory, antioxidant, endothelial-protective and plaque-stabilizing activity. Along this line, statins may also exert acute and long-term effects on renal function. We present a narrative literature review that summarizes arguments in favor of or against the preventive and/or therapeutic use of statins in kidney-related diseases or complications...
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607299/therapeutic-approaches-of-obstructive-sleep-apnea-in-china
#8
Wen-Yang Li, Wei Wang
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607298/timing-of-the-treatment-of-portal-vein-thrombosis-in-patients-with-cirrhosis-a-german-hepatologist-s-perspective
#9
Martin Rössle, Michael Schultheiss
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607297/timing-of-anticoagulation-for-portal-vein-thrombosis-in-liver-cirrhosis-an-italian-internist-s-perspective
#10
Nicoletta Riva, Walter Ageno
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29607296/timing-of-anticoagulation-for-portal-vein-thrombosis-in-liver-cirrhosis-a-us-hepatologist-s-perspective
#11
Patrick G Northup, Jessica P E Davis
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340282/should-vasoconstrictors-be-considered-in-a-cirrhotic-patient-with-acute-non-variceal-upper-gastrointestinal-bleeding
#12
Xingshun Qi, Hongyu Li, Xiaodong Shao, Zhendong Liang, Xia Zhang, Ji Feng, Hao Lin, Xiaozhong Guo
Varices manifest as a major etiology of upper gastrointestinal bleeding in patients with chronic liver diseases, such as liver cirrhosis and hepatocellular carcinoma. By contrast, non-variceal upper gastrointestinal bleeding is rare. Pharmacological treatment differs between patients with variceal and non-variceal bleeding. Vasoconstrictors are recommended for the treatment of variceal bleeding, rather than non-variceal bleeding. In contrast, pump proton inhibitors are recommended for the treatment of non-variceal bleeding, rather than variceal bleeding...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340281/urgent-need-to-define-pretreatment-predictors-of-immune-check-point-inhibitors-related-endocrinopathies-a-case-report-and-review-of-literature
#13
Vishal Sehgal, Richard Childress
Immune check point inhibitors have revolutionized the treatment of metastatic malignancies. They are a promising area in oncology and more drugs are likely to be available in the coming years. Along with the promise of better response oncologically, there is an increased incidence of endocrinopathies related to autoimmunity. This case report illustrates the dramatic development of hypothyroidism in a patient with underlying subclinical hyperthyroidism. It also suggests the potential pretreatment predictors of endocrinopathies related to these immune check point inhibitors...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340280/serum-vitamin-d-levels-in-treatment-na%C3%A3-ve-chronic-hepatitis-b-patients
#14
Ebada Said, Waleed El Agawy, Rehab Ahmed, Mohamed Hassany, Amal Ahmed, Hanan Fouad, Hosam Baiumy
Background and Objectives: According to the demographic health survey conducted in 2015, Egypt had 10% documented prevalence of anti-HBc positive patients aged 1-59 and 1% viremic patients amongst the population in the same age group, with a domination of genotype D. Several studies claimed the possible role of vitamin D deficiency in hepatitis B virus (HBV) replication and disease progression. Patients and Methods: Serum vitamin D levels [25(OH D3] were assessed in 96 HBeAg negative non-cirrhotic chronic HBV patients and 25 healthy subjects classified as following: Group I: 48 chronic HBV patients with persistently normal ALT levels and HBV DNA level < 2000 IU/mL for ≥ 6 months; Group II: 48 chronic HBV patients with CHB with persistently elevated ALT and HBV DNA level ≥ 2000 IU/mL for ≥ 6 months; and Group III: 25 apparently healthy subjects with normal liver enzymes and negative hepatitis viral markers were taken as the control group...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340279/effect-of-mthfr-a1298c-and-mtrr-a66g-genetic-mutations-on-homocysteine-levels-in-the-chinese-population-a-systematic-review-and-meta-analysis
#15
Jiancheng Wang, Nengtai Ouyang, Long Qu, Tengfei Lin, Xianglin Zhang, Yaren Yu, Chongfei Jiang, Liling Xie, Liping Wang, Zhigui Wang, Shuzhen Ren, Shizhi Chen, Jiang Huang, Fang Liu, Weiqing Huang, Xianhui Qin
Background and Objectives: The Chinese population typically has inadequate folate intake and no mandatory folic acid fortification. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Hcy has been implicated in the pathogenesis of cardiovascular disease. We conducted a meta-analysis to assess whether the MTHFR gene A1298C and the MTRR gene A66G polymorphisms affect Hcy levels in the Chinese population...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340278/endoscopic-ultrasound-guided-pancreatic-pseudocyst-drainage-with-lumen-apposing-metal-stents-or-plastic-double-pigtail-stents-a-multifactorial-analysis
#16
Nan Ge, Jinlong Hu, Siyu Sun, Enqiang Linghu, Zhendong Jin, Zhaoshen Li
Objective: To compare the efficiency of plastic and metal stents for symptomatic pancreatic pseudocyst (PP) drainage and analyze other main associated factors that affect the outcome of drainage therapy. Method: Rates of technical and clinical success, procedure-related side effects (hemorrhage, stent migration, and cyst rupture), reinterventions, and duration of hospital stay. Results: There were 52 patients, 40 patients underwent plastic stent placement and 12 patients underwent lumen-apposing metal stent (LAMS) placement...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340277/comparative-computed-flow-dynamic-analysis-of-different-optimization-techniques-in-left-main-either-provisional-or-culotte-stenting
#17
Gianluca Rigatelli, Fabio Dell'Avvocata, Marco Zuin, Sara Giatti, Khanh Duong, Trung Pham, Nguyen Si Tuan, Dobrin Vassiliev, Ramesh Daggubati, Thach Nguyen
Background and Objectives: Provisional and culotte are the most commonly used techniques in left main (LM) stenting. The impact of different post-dilation techniques on fluid dynamic of LM bifurcation has not been yet investigated. The aim of this study is to evaluate, by means of computational fluid dynamic analysis (CFD), the impact of different post-dilation techniques including proximal optimization technique (POT), kissing balloon (KB), POT-Side-POT and POT-KB-POT, 2-steps Kissing (2SK) and Snuggle Kissing balloon (SKB) on flow dynamic profile after LM provisional or culotte stenting...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340276/clinical-value-of-ultrasonography-in-diagnosis-of-pulmonary-embolism-in-critically-ill-patients
#18
Ran Zhu, Xiao-Chun Ma
Pulmonary embolism (PE) is a clinical emergency that will increase the mortality if complicated with unstable hemodynamics. Because of its nonspecific clinical symptoms, it's a great challenge to make a PE diagnosis. The golden standard to diagnose PE is computed tomography of pulmonary artery (CTPA), but a diagnosis of PE also composed of evaluation of PE risk factors, possibilities, and risk stratification. Ultrasonography may detect right ventricle strain related to hemodynamic change, intravascular thrombosis, thrombosis in right heart or pulmonary arteries, pulmonary infarction, and local pleural effusion...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340275/timing-of-transjugular-intrahepatic-portosystemic-shunt-for-budd-chiari-syndrome-an-italian-hepatologist-s-perspective
#19
Andrea Mancuso
Budd-Chiari syndrome (BCS) management flow-chart is derived from experts' opinion and is not evidence-based. Guidelines suggest BCS management should follow a stepwise strategy: medical therapy as first-line treatment, revascularization or transjugular intrahepatic portosystemic shunt (TIPS) if no response to medical therapy, and liver transplant as rescue therapy. Recent evidence suggests that only medical therapy results in a bad long-term outcome. The biggest criticism of guidelines is the indication that BCS should receive further treatment only when hemodynamic consequences of portal hypertension become clinically evident...
December 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29340274/breaking-through-restricting-bottleneck-for-better-asthma-control
#20
Ding Zhu, Chao Zhang, Huahao Shen, Songmin Ying
No abstract text is available yet for this article.
December 2017: Journal of Translational Internal Medicine
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