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International Journal of Retina and Vitreous

Abdullah Ozkaya, Gurkan Erdogan, Gokhan Demir
Background: To evaluate the surgical outcomes of vitrectomy in patients with foveal herniation associated with epiretinal membrane (ERM). Methods: This was a retrospective case series. The patients who had a foveal herniation associated with ERM, underwent vitrectomy, and had a minimum follow-up period of 12 months were included. The visual and anatomical outcomes were assessed during the first 12 months of follow-up and at the last follow-up visit. The main outcome measure was the reorganization pattern of foveal pit at month 12...
2018: International Journal of Retina and Vitreous
Sukriti Ahuja, Sandeep Saxena, Carsten H Meyer, Jagjit S Gilhotra, Levent Akduman
Background: To evaluate the association of central subfield thickness (CST) and cube average thickness (CAT) with ellipsoid zone (EZ) disruption on spectral domain optical coherence tomography (SD-OCT) in patients of diabetic retinopathy (DR). Methods: Cross sectional study including consecutive patients of type 2 diabetes mellitus [without DR (No DR, n = 97); non-proliferative DR (NPDR, n = 91); proliferative DR (PDR, n = 83)] and healthy controls (n = 82) was undertaken...
2018: International Journal of Retina and Vitreous
Julia de Lima Farah, Ronaldo Sano, Ieda Maria Longo Maugéri, Daniela Teixeira, Mayari Eika Ishimura, Gabriela Martins, Lycia M J Mimica, Cely Barreto da Silva, Carsten H Meyer, João Rafael de Oliveira Dias, Gabriel Costa de Andrade, Michel Eid Farah
Purpose: To investigate the binding affinity, stability, and sterility of aflibercept and ziv-aflibercept to vascular endothelial growth factor (Holash et al. in Proc Natl Acad Sci USA 99(17):11393-11398, 2002. 10.1073/pnas.172398299) after compounding and storage for up to 28 days at 4 °C and - 8 °C. Methods: Tuberculin-type 1-mL syringes were prepared containing aflibercept (40 mg/mL) and ziv-aflibercept (25 mg/mL). Samples were stored at 4 °C and - 8 °C for 0, 14, and 28 days and evaluated for the binding affinity of anti-VEGF to VEGF and stability using enzyme-linked immunosorbent assays...
2018: International Journal of Retina and Vitreous
Rafael B de Araújo, Breno M S Azevedo, Thais S Andrade, Maria F Abalem, Mário L R Monteiro, Pedro C Carricondo
Background: Pupil dilation and mydriasis maintenance throughout vitreoretinal surgeries are important to allow satisfactory fundus visualization and reduce risk of complications. The purpose of this study is to evaluate the role of subconjunctival epinephrine 0.1% injection in mydriasis maintenance during vitrectomy. Methods: Ninety-nine consecutive patients undergoing vitrectomy were enrolled. All subjects were preoperatively dilated with tropicamide 1%. Each patient was randomly allocated either in the epinephrine or placebo group...
2018: International Journal of Retina and Vitreous
Salman Sarwar, Muhammad Hassan, Mohamed K Soliman, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir J Sepah
Background: Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported in literature. In the index study, optical coherence tomography angiography (OCTA) was used to assess the diurnal variation of the VFD in the choriocapillaris of subjects with no known ocular disease. Methods: Fifty eyes with no known ocular disease (25 subjects) were included. OCTA images were acquired using AngioVue (Optovue, Fremont, CA, USA) at two different time points on a single day: 9:00 AM and 6:00 PM...
2018: International Journal of Retina and Vitreous
Jose S Pulido, Lauren A Dalvin, Timothy W Olsen, Fukutaro Mano, Michael Yu, Carol L Shields
Background: To describe a case of von Hippel-Lindau disease with peripheral retinal nonperfusion. Case presentation: A 66-year-old female with known cerebellar and midbrain hemangioblastomas was evaluated for a retinal hemangioblastoma in the right eye. She underwent widefield fluorescein angiography, which showed hyperfluorescence localized to the hemangioblastoma surrounded by peripheral retinal nonperfusion in the same quadrant. Conclusions: Further widefield imaging studies are required to determine if peripheral retinal nonperfusion is a common finding in von Hippel-Lindau disease...
2018: International Journal of Retina and Vitreous
Ogugua Ndubuisi Okonkwo, Adekunle Olubola Hassan, Olufemi Oderinlo, Michael Ekuoba Gyasi
Aim: To report the long-term outcome of the management of a series of culture proven post pars plana vitrectomy endophthalmitis in which the infective agent was in the silicone oil used as an endotamponade. The isolates were Burkholderia cepacia and Pseudomonas aeruginosa . Method: A retrospective interventional reporting of a series consisting of a cluster of five cases. Cases: Five consecutive patients received the same batch of 5000-centistoke silicone oil as endotamponade at the conclusion of vitreoretinal surgery and presented with features of acute intraocular inflammation, which was due to an infective cause...
2018: International Journal of Retina and Vitreous
Irini Chatziralli, Aikaterini Vlachodimitropoulou, Chrysoula Daoula, Christina Vrettou, Eleni Galani, George Theodossiadis, Panagiotis Theodossiadis
Purpose: The purpose of this review is to examine the role of eplerenone in the treatment of central serous chorioretinopathy (CSCR). Methods: A comprehensive search of the PubMed database has been conducted regarding eplerenone for CSCR, while studies using spironolactone were excluded. Articles and book chapters cited in the reference lists of articles obtained by this method were reviewed and included when considered appropriate, while the retrieved articles were filtered manually to exclude duplicates...
2018: International Journal of Retina and Vitreous
Vikas Ambiya, Ashok Kumar, V K Baranwal, Gaurav Kapoor, Amit Arora, Nidhi Kalra, Jyoti Sharma
Background: To evaluate subfoveal choroidal thickness (SFCT) change in diabetes and in various grades of diabetic retinopathy (DR) in comparison to age-matched healthy subjects. Methods: This prospective observational study included 100 eyes of diabetic patients without DR (group D), 100 eyes with DR (group R), and 100 eyes of healthy subjects (group N). The assessment included demographics, duration of diabetes, comprehensive ocular examination, fundus photography with/without fundus fluorescein angiography, spectral domain optical coherence tomography with enhanced depth imaging to assess SFCT...
2018: International Journal of Retina and Vitreous
Niroj Kumar Sahoo, Pasyanthi Balijepalli, Sumit Randhir Singh, Mahima Jhingan, Sirisha Senthil, Jay Chhablani
Background: The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically. With the advent of anti-fibrotic agents in the management of glaucoma, the rates of vitreoretinal complications have become more frequent. Main body: Common retinal complications after glaucoma surgeries include choroidal detachment; ocular decompression retinopathy; haemorrhagic choroidal detachment; hypotony maculopathy; malignant glaucoma; vitreous haemorrhage; bleb endophthalmitis; retinal detachment...
2018: International Journal of Retina and Vitreous
Ugo Introini, Giuseppe Casalino, Elona Dhrami-Gavazi, Sri Krishna Mukkamala, Sarah Mrejen, Hermann Schubert, Salomon Y Cohen, Claudio Azzolini, Francesco Bandello, Stanley Chang, Lawrence A Yannuzzi
Purpose: To report the clinical course and multimodal imaging features of acute zonal occult outer retinopathy (AZOOR) complicated by choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (VEGF) treatment or photodynamic therapy (PDT). Methods: Observational case series. Retrospective analysis of patients presenting to different institutions with evidence of AZOOR and neovascular lesions. Diagnosis of AZOOR was made on the basis of clinical presentation and multimodal imaging...
2018: International Journal of Retina and Vitreous
Dmitrii S Maltsev, Alexei N Kulikov, Bhushan Uplanchiwar, Luiz H Lima, Jay Chhablani
Objectives: To compare the efficacy and safety of conventional and navigated laser photocoagulation as the primary treatment option for retinal arteriolar macroaneurysm (RAM). Methods: Eleven (9 male and 2 females, mean age 65.1 ± 12.1 years) and 17 (13 male and 4 females, mean age 66.2 ± 8.9 years) patients were included in conventional laser photocoagulation (CLP) and navigated laser photocoagulation (NLP) groups, respectively. The primary outcome measures were LogMAR best-corrected visual acuity (BCVA) and central retinal thickness at the end of the follow-up...
2018: International Journal of Retina and Vitreous
Francisco Olguin-Manríquez, Ana Bety Enríquez, Nicolás Crim, Miroslava Meraz-Gutierrez, Vidal Soberón-Ventura, Ismael Ávila, Virgilio Morales-Canton, Juan Manuel Jimenez-Sierra
Purpose: To describe characteristics of choroidal osteomas (CO), using ocular ultrasound, fluorescein angiography, ultra-widefield retinal imaging, ultra-widefield autofluorescence, optical coherence tomography, enhanced-depth-imaging OCT, and OCT angiography (OCT-A). Methods: Retrospective, observational case series study. Clinical records from patients with diagnosis of CO who underwent complete imaging evaluation were analyzed. Results: Sixteen eyes from 11 patients were included...
2018: International Journal of Retina and Vitreous
Luiz H Lima, Michel E Farah, Glenwood Gum, Pamela Ko, Ricardo A de Carvalho
Background: To evaluate the efficacy of selective episcleral delivery of celecoxib formulated in a sustained-release episcleral exoplant on a model of retinal and choroidal neovascularization induced in rabbits by subretinal injection of matrigel combined with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF). Methods: Nine New Zealand white rabbits were randomly assigned to three groups (episcleral celecoxib exoplant, intravitreal bevacizumab injection and control group)...
2018: International Journal of Retina and Vitreous
Y C Venu Gopal Reddy, Anuj Sharma, Adheesh P Shetty, Syed Mohideen Abdul Kader
Background: Iodine deficiency is a common preventable cause of intellectual and developmental disabilities. Iodine in the form of potassium iodate is added to the common salt under the National Iodine Deficiency Disorder Control Program in India. Overdose of iodate can lead to retinal toxicity. Case presentation: We hereby present a case of a 34 year old male patient who presented to us 10 years following iodate ingestion. There was widespread outer retinal atrophy, foveal atrophy and sub-retinal fibrosis noted on fundus evaluation...
2018: International Journal of Retina and Vitreous
Matthew R Starr, Suzanne M Norby, John P Scott, Sophie J Bakri
Background: The ocular manifestations of cystic fibrosis typically present with surface irritation or nyctalopia due to Vitamin A deficiency, however, there have been two previous reports of patients with cystic fibrosis that developed retinal vein occlusions. These reports hypothesized that either elevated fibrinogen levels due to chronic infections or elevated homocysteine levels have predisposed patients with cystic fibrosis to develop retinal vein occlusions. Case presentation: We present a case of a 35-year-old male with cystic fibrosis complicated by chronic sinusitis with no history of organ transplantation or chronic pulmonary infections who presented with an acute branch retinal vein occlusion in his left eye with associated macular edema...
2018: International Journal of Retina and Vitreous
Li-Anne S Lim, Guillermo Fernandez-Sanz, Steven Levasseur, John R Grigg, Alex P Hunyor
Background: Macular holes in children are generally associated with trauma. Case presentation: We report the first case of an idiopathic full thickness macular hole in a 10-year-old girl. 23-gauge transconjunctival pars plana vitrectomy, induction of a posterior vitreous detachment, ILM blue-assisted internal limiting membrane peel, fluid-air exchange and air-26% sulfur hexafluoride (SF6) exchange was performed with subsequent macular hole closure. Conclusion: This is the first reported case of an idiopathic full thickness macular hole in a child...
2018: International Journal of Retina and Vitreous
Jose S Pulido, Patrick B Johnston, Grzegorz S Nowakowski, Alessia Castellino, Harish Raja
[This corrects the article DOI: 10.1186/s40942-018-0120-4.].
2018: International Journal of Retina and Vitreous
Charles M Calvo, Mary Elizabeth Hartnett
Background: Ultra-widefield angiography is the latest technology in the evolution of fundus fluorescein angiography. With the ability to capture up to 200° of the fundus in a single image, far peripheral retinal pathology can be imaged. Generally, obtaining high-quality fundus fluorescein angiography in a child without sedation in the outpatient setting is exceedingly challenging. Therefore, there are advantages to imaging platforms that can capture the peripheral retina in young children without anesthesia...
2018: International Journal of Retina and Vitreous
Erick Omar Flores-Villalobos, J Abel Ramírez-Estudillo, Atzin Robles-Contreras, Jacqueline L Oliva-Ramírez
Background: To determine the effect of the silicone on the dexamethasone intravitreal implant. Methods: Basic, experimental, prospective and transversal study performed at the hospital "Nuestra Señora de la Luz" in Mexico City. One dexamethasone implant was placed in a test tube with 4 mL of each tamponade medium: 1000cS, 5000cS and heavy silicone oil; basic saline solution was used as the control medium. Photographs were taken weekly for 12 months...
2018: International Journal of Retina and Vitreous
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