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International Journal of Retina and Vitreous

Jose S Pulido, Patrick B Johnston, Grzegorz S Nowakowski, Allessia Castellino, Harish Raja
Background: To describe the recent diagnostic and treatment options for the most predominant form of primary vitreoretinal lymphoma (PVRL), namely diffuse large B cell lymphoma. This is mainly based on the experience at the Mayo Clinic as well as a partial review of the literature. MYD88 L265P mutation is seen in about 80% of cases; therefore, a polymerase chain reaction for this mutation helps in making the diagnosis that has been notoriously difficult to make. Local therapy using intravitreal methotrexate and rituximab has been very helpful in the treatment of the local disease...
2018: International Journal of Retina and Vitreous
Kelley J Bohm, Y Pierre Gobin, Jasmine H Francis, Gabrielle McInerney, Anahita Dabo-Trubelja, Paul H Dalecki, Brian P Marr, David H Abramson
Background: Methylenetetrahydrofolate reductase (MTHFR) genetic mutations and intra-procedural inhaled nitrous oxide (N2 O) independently increase blood levels of homocysteine, a compound associated with thrombosis. Patients with MTHFR mutations who also receive N2 O during ophthalmic artery chemotherapy (OAC) for retinoblastoma may have a heightened thrombotic risk. Case presentations: Single-center retrospective review of pediatric patients with advanced retinoblastoma who received OAC and developed choroidal infarcts...
2018: International Journal of Retina and Vitreous
Lorenzo Ferro Desideri, Fabio Barra, Simone Ferrero, Aldo Vagge
The aim of this article is to underline the effect of pregnancy on the variations of choroidal thickness caused by hormonal and haemodynamic changes.
2018: International Journal of Retina and Vitreous
Julio Zaki Abucham-Neto, André Augusto Miranda Torricelli, Aline Cristina Fioravanti Lui, Sarah Napoli Guimarães, Heloisa Nascimento, Caio Vinícius Regatieri
Background: To describe optical coherence tomography angiography (OCT-A) findings in patients with retinal vasculitis and to compare them to current fluorescein angiography (FA) findings. Methods: This was an observational case series. Nineteen eyes in 10 patients with retinal vasculitis of various etiologies were imaged with FA (TRC-50DX, Topcon) and OCT-A (SD-OCT, Optovue). The images were reviewed and analyzed. Results: The mean age was 36 years (range 24-67 years); there were three males and seven females...
2018: International Journal of Retina and Vitreous
Manila Khatri, Sandeep Saxena, Apjit Kaur, Shashi K Bhasker, Manoj Kumar, Carsten H Meyer
Background: Retinal pigment epithelium (RPE) plays a significant role in maintenance of integrity of retinal photoreceptors and choriocapillaries. RPE derives its blood supply through ophthalmic artery (OA) via choriocapillaries. RPE topographic alterations have been observed to be associated with severity of retinopathy. The present study was undertaken to assess the correlation between resistive index (RI) of the OA with RPE topographic alterations on Spectral-Domain optical coherence tomography (SD-OCT), to our knowledge, it is for the first time...
2018: International Journal of Retina and Vitreous
S K Mishra, A Gupta, S Patyal, S Kumar, K Raji, A Singh, V Sharma
Purpose: Among the retinal vascular diseases, burden of retinal vein occlusion is most common immediately after diabetic retinopathy. Intravitreal corticosteroids are gaining popularity in managing macular edema (ME) of RVO. Our study compares efficacy and safety of intravitreal triamcinolone (IVTA) and dexamethasone implant (IVD) over 6 months. Methods: This comparative, prospective, randomized study on 40 patients of non-ischemic central RVO with significant ME (> 330 μm) of < 3 months duration...
2018: International Journal of Retina and Vitreous
Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina, Jay Chhablani
Background: To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC. Methods: In this retrospective cohort study, swept source optical coherence tomography scans of eyes with steroid-associated CSC (group A) were compared with the same in idiopathic CSC (group B). The key features included central subfield retinal thickness, subfoveal choroidal thickness, subfoveal large choroidal vessel diameter, subretinal deposits, retinal pigment epithelial irregularities, double layer sign, hyperreflective dots, intraretinal fluid, and choroidal vascularity index (ratio of choroidal luminal area and total choroidal area, measured on a high definition horizontal 9 mm OCT B-scan...
2018: International Journal of Retina and Vitreous
Nasser Shoeibi, Seyedeh Maryam Hosseini, Touka Banaee, Mohammad-Reza Ansari-Astaneh, Majid Abrishami, Hamid Ahmadieh
Purpose: Reporting a special clinical finding after intravitreal bevacizumab monotherapy for retinopathy of prematurity. Methods: In a retrospective case series, the clinical courses of five premature infants with similar vitreous changes after a single dose of intravitreal bevacizumab (IVB) injection without additional laser therapy were reported. Results: The mean post-conceptional age at IVB injection was 39.8 ± 2.2 (range 37-43) weeks...
2018: International Journal of Retina and Vitreous
Raul Velez-Montoya, J Abel Ramirez-Estudillo, Carl Sjoholm-Gomez de Liano, Francisco Bejar-Cornejo, Jorge Sanchez-Ramos, Jose Luis Guerrero-Naranjo, Virgilio Morales-Canton, Sergio E Hernandez-Da Mota
Background: To assess closure rate after a single surgery of large macular holes and their visual recovery in the short term with three different surgical techniques. Methods: Prospective multicenter randomized controlled trial. We included treatment-naïve patients with diagnosis of large macular hole (minimum diameter of > 400 µm). All patients underwent a comprehensive ophthalmological examination. Before surgery, the patients were randomized into three groups: group A: conventional internal limiting membrane peeling, group B: inverted-flap technique and group C: free-flap technique...
2018: International Journal of Retina and Vitreous
Ahmad Mirshahi, Alireza Lashay, Mohammad Reza Mehrabi Bahar, Mojtaba Abrishami
Background: Mitomycin C (MMC) as an alkylating agent is miscellaneous an antineoplastic, antibiotic and ophthalmic agent. Here we aim to report a case of inadvertent intravitreal MMC injection instead of Avastin in case of diabetic macular edema. Case presentation: A 53 years old woman was planned to receive intravitreal Avastin injection, but accidentally, 0.05 ml of MMC 0.2% was injected. Best corrected visual acuity (BCVA) was 20/160 before injection. After 2 days, patient was referred to a tertiary referral eye center...
2018: International Journal of Retina and Vitreous
Nicole Antunes de Almeida, Osias Francisco de Souza
Background: Evaluation of the impact of different macular optical coherence parameters on visual acuity as early as 1 day after injection of ranibizumab in patients with subfoveal exsudative age-related macular degeneration. Methods: This was an interventional, non randomized, open label prospective study, where we evaluated 20 eyes of 20 patients affected by exudative age-related macular degeneration. These patients were treated with injections of ranibizumab between February 2013 and January 2015...
2018: International Journal of Retina and Vitreous
Camila Zanella Benfica, Teresinha Zanella, Lucas Brandolt Farias, Maria Lúcia Rocha Oppermann, Luis Henrique Santos Canani, Daniel Lavinsky
Background: The impact of pregnancy on the choroid is still under investigation. The aim of this study is to compare choroidal thickness measurements of healthy pregnant women in the third trimester and healthy non-pregnant women using spectral-domain optical coherence tomography (OCT). Methods: This cross-sectional study included 122 eyes of 61 women, divided into two groups: 27 healthy pregnant women in the third trimester and 34 age-matched healthy non-pregnant women...
2018: International Journal of Retina and Vitreous
Letícia Pinto Coelho Jorge, Carlos Eduardo Gonçalves Pereira, Eduardo Jorge, Marcos Pereira de Ávila
Background: To evaluate macular pigment optical density (MPOD) and to identify its determinants in a sample of Brazilian individuals. Methods: This was a cross-sectional study. One hundred three healthy individuals had both eyes photographed using a Visucam 500 digital fundus camera (Carl Zeiss Meditec, Jena, Germany) in combination with the MPOD module. Four variables were obtained: maximum MPOD, mean MPOD, MPOD volume, and MPOD area. Demographic data and information on lifestyle habits were also collected...
2018: International Journal of Retina and Vitreous
Shira Sheen-Ophir, Mordechai Rosner, Alexander Rubowitz
Background: Polydimethyl silicones (silicone oils) are used in complex retinal surgeries, including difficult or recurrent retinal detachments, severe eye trauma, and other indications for long term tamponade. Two major problems with currently available silicone oils are emulsification and recurrent retinal detachment. The primary endpoint of this study was to evaluate the toxicity and safety of high viscosity silicone oils and second, the feasibility of using them with currently available vitrectomy systems...
2018: International Journal of Retina and Vitreous
Fábio Barreto Morais
No abstract text is available yet for this article.
2018: International Journal of Retina and Vitreous
Aristófanes Mendonça Canamary, Walter Yukihiko Takahashi, Juliana Maria Ferraz Sallum
Autoimmune retinopathy (AIR) is a rare and still poorly understood immune-mediated disease that may cause inflammation from circulating autoantibodies against the retina. It may be related to history of autoimmune disease in the patient or in a family member or the presence of neoplastic disease in the individual. The disease may be subdivided into paraneoplastic and non-paraneoplastic AIR. When related to melanoma, it is referred to as MAR, and when related to other cancers, it is called CAR. The exact prevalence of AIR is unknown...
2018: International Journal of Retina and Vitreous
Mahima Jhingan, Kerul Marsonia, Dhananjay Shukla, Philip J Rosenfeld, Jay Chhablani
Background: To study the interaction between idiopathic macular telangiectasis type 2 (MacTel2) and coexistent diabetic retinopathy (DR) during long term follow up. Methods: A retrospective chart review was done for all eyes with MacTel2 and DR with a minimum 2 years follow up. Eyes with other retinal disorders and poor quality imaging were excluded. Data collected included demographics, presenting visual acuity, systemic evaluation, treatments done, duration of follow up, and final visual outcomes...
2017: International Journal of Retina and Vitreous
Fernando Korn Malerbi, Caio Vinicius Regatieri, João Roberto de Sa, Paulo Henrique Morales, Michel Eid Farah, Sergio Atala Dib
Background: To report fluorescein angiography findings in a group of albuminuric Type 1 diabetes mellitus (T1DM) patients without diabetic retinopathy. Methods: Fifteen albuminuric T1DM patients with normal/near normal estimated glomerular filtration rate without diabetic retinopathy underwent fluorescein angiography; presence of microaneurysms, vascular permeability changes and retinal malperfusion were evaluated. Results: Fluorescein angiography revealed microaneurysms, blood-retinal barrier breakdown and retinal ischemia in 10 (67%) and 11 (73%); 8 (53%) and 9 (60%); 2 (13%) and 5 (33%) of patients at baseline and follow up, respectively...
2017: International Journal of Retina and Vitreous
Fernando José De Novelli, Mauro Goldbaum, Mario Luiz Ribeiro Monteiro, Fabio Bom Aggio, Mario Junqueira Nóbrega, Walter Yukihiko Takahashi
Purpose: To compare the recurrence rate and need for reoperation after epiretinal membrane surgery with and without removal of the internal limiting membrane. Methods: In this retrospective study, 125 patients operated for epiretinal membrane removal were evaluated, with a minimum 6-month follow-up. Removal of the epiretinal membrane (ERM) was performed in 78 patients, while 47 had removal of the epiretinal membrane associated with internal limiting membrane peeling (ERM + ILM)...
2017: International Journal of Retina and Vitreous
Radwan Ajlan, Jordan Isenberg, Ghassan Cordahi, Renaud Duval, Sébastien Olivier, Flavio Rezende
Background: To compare the primary anatomical outcome of pars plana vitrectomy, 360° peripheral endolaser, and 15% octafluoropropane C3 F8 gas tamponade in patients with uncomplicated rhegmatogenous detachment and inferior retinal breaks, after 24-h postoperative prone positioning to similar patients with 1 week postoperative prone positioning. Methods: Records of 5500 patients who underwent pars plana vitrectomy between 2008 and 2015 were retrieved. Collected data included age, gender, number of retinal quadrants with retinal breaks, number of retinal breaks, macula status on presentation (attached or detached), phakic status (phakic, pseudophakic, or aphakic), and primary anatomical outcome (at 1 and 3 months post-operative)...
2017: International Journal of Retina and Vitreous
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