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Laryngoscope Investigative Otolaryngology

Jonathon O Russell, Christopher R Razavi, Mai G Al Khadem, Michael Lopez, Sejal Saraf, Jason D Prescott, Heather M Starmer, Jeremy D Richmon, Ralph P Tufano
Objectives: The robotic retroauricular approach and transoral endoscopic thyroidectomy vestibular approach (TOETVA) have been employed to avoid anterior neck scarring in thyroidectomy with good success. However, outcomes have yet to be compared between techniques. We compare our initial clinical experience with these approaches for thyroid lobectomy at our institution. Methods: A review of initial consecutive patients who underwent robotic facelift thyroidectomy (RFT) (August 2011-August 2016) at our institution was conducted...
October 2018: Laryngoscope Investigative Otolaryngology
Poupak Fallahi, Silvia Martina Ferrari, Gabriele Materazzi, Francesca Ragusa, Ilaria Ruffilli, Armando Patrizio, Paolo Miccoli, Alessandro Antonelli
Objective: No consistent data are present in literature about the effectiveness of Levothyroxine (L-T4) liquid formulation in patients without malabsorption after thyroidectomy. The aim of this study is to compare the effectiveness of L-T4 liquid formulation, with L-T4 tablets, in thyroid cancer patients after thyroidectomy (without malabsorption or drug interference). Methods: One hundred five patients were recruited; 52 patients were treated with liquid L-T4 formulation, while 53 with L-T4 tablets, at the same dosage (1...
October 2018: Laryngoscope Investigative Otolaryngology
Melodi Koşaner Kließ, Arne Ernst, Jan Wagner, Philipp Mittmann
Objective s: Energy emitting, active middle ear implants (aMEI) have taken more than two decades of research to reach technological sophistication, medical safety, and regulatory approval to become a powerful tool in treating sensorineural, conductive, and mixed hearing loss. The present review covers this era. Data Source: Literature found from searching Pubmed (MEDLINE); EMBASE, SciSearch, German Medical Science Journals and Meetings, and The Cochrane Library; and published as of February 2017...
October 2018: Laryngoscope Investigative Otolaryngology
Makoto Hosoya, Shujiro B Minami, Chieko Enomoto, Tatsuo Matsunaga, Kimitaka Kaga
Objectives: We sought to determine how the pathology altered electrically evoked auditory brainstem responses (EABRs) in patients with hearing loss by evaluating EABRs in auditory neuropathy patients with OTOF mutations comparing with various types of congenital deafness. Methods: We included 15 patients with congenital hearing loss, grouped according to pathology: OTOF mutations (n = 4), GJB2 mutations (n = 4), SLC26A4 mutations (n = 4), or cytomegalovirus infections (n = 3)...
October 2018: Laryngoscope Investigative Otolaryngology
Omer J Ungar, Adi Brenner-Ullman, Oren Cavel, Yahav Oron, Oshri Wasserzug, Ophir Handzel
Hypothesis: There may be an association between a neurovascular conflict (NVC) of the auditory nerve and unilateral sudden sensorineural hearing loss (SSNHL). Background: Compression of cranial nerves by vascular structures can lead to significant symptomatology that may require surgical decompression. Notable examples are trigeminal neuralgia and hemifacial spasm. Magnetic resonance imaging (MRI) is part of the workup for SSNHL, and it may depict an NVC of the auditory nerve...
October 2018: Laryngoscope Investigative Otolaryngology
Maria C Turcotte, Erica G Herzberg, Matina Balou, Sonja M Molfenter
Objectives: Edema is a frequent clinical observation following chemoradiation treatment (CRT) of oral/oropharyngeal cancer and is thought to contribute to post-CRT swallowing impairment. Our aims were to reliably quantify pharyngeal edema pre- and post-CRT from videofluoroscopic (VF) swallowing studies and to explore the relationship between edema and swallowing impairment. Swallowing impairment was captured using patient-reported swallowing outcomes (EAT-10) and with VF confirmation of impairment (DIGEST)...
October 2018: Laryngoscope Investigative Otolaryngology
Chau T Nguyen, Malcolm B Taw, Marilene B Wang
Objective: To review the literature on integrative care of the patient with head and neck cancer. Methods: A review of the English language literature for articles relating to integrative care of patients with head and neck cancer, focusing on treatment of sequelae of surgery and chemoradiation. Results: Many studies show a significant utilization of nontraditional (complementary/integrative) treatments by patients in dealing with head and neck cancer...
October 2018: Laryngoscope Investigative Otolaryngology
Loes Bruijstens, Imke Titulaer, Gert Jan Scheffer, Monique Steegers, Frank van den Hoogen
Objectives: ENT surgeons and anesthesiologists work closely together in managing challenging airway cases. Sharing knowledge, experiences, and expectations interdisciplinary is essential in order to facilitate decision-making and adequate management in emergency front-of-neck airway cases. Methods: A survey was performed, to analyze level of experience, technique of preference, training, knowledge of material and protocols, and self-efficacy scores of Dutch ENT surgeons and residents in performing an urgent or emergency front-of-neck airway...
October 2018: Laryngoscope Investigative Otolaryngology
Gerrit C Langhout, Koert F D Kuhlmann, Pim Schreuder, Torre Bydlon, Ludi E Smeele, Michiel W M van den Brekel, Henricus J C M Sterenborg, Benno H W Hendriks, Theo J M Ruers
Background: Careful identification of nerves during head and neck surgery is essential to prevent nerve damage. Currently, nerves are identified based on anatomy and appearance, optionally combined with electromyography (EMG). In challenging cases, nerve damage is reported in up to 50%. Recently, optical techniques, like diffuse reflectance spectroscopy (DRS) and fluorescence spectroscopy (FS) show potential to improve nerve identification. Methods: 212 intra-operative DRS/FS measurements were performed...
October 2018: Laryngoscope Investigative Otolaryngology
Abdul Nassimizadeh, S M Zaidi, Mohammad Nassimizadeh, Amir Kholief, Shahzada K Ahmed
Background/Objectives: Endoscopic surgery has a distinct disadvantage compared to direct vision: loss of binocular vision. Three-dimensional endoscopy has been welcomed due to the promise of improving stereopsis. Methods: Prospective randomized study of junior doctors with minimal endoscopic experience, using both two-dimensional and three-dimensional, zero-degree, 4-mm Storz endoscopes. Data was collected using validated, standardized training models, both objectively and subjectively...
October 2018: Laryngoscope Investigative Otolaryngology
Bradley J Goldstein, Rhea Choi, Garrett M Goss
Objectives: To investigate epigenetic mechanisms contributing to regulation of cellular renewal and neurogenesis in adult olfactory epithelium (OE). Study Design: Prospective basic science study. Methods: Olfactory basal cell cultures were prepared from adult mice per established protocols. in vivo studies were performed using the mouse methimazole lesion-regeneration paradigm. Nasal tissue sections were prepared from adult mice 7 days following lesion, or from unlesioned controls...
October 2018: Laryngoscope Investigative Otolaryngology
Che-Wei Wu, Hui Sun, Guang Zhang, Hoon Yub Kim, Antonina Catalfamo, Mattia Portinari, Paolo Carcoforo, Gregory W Randolph, Young Jun Chai, Gianlorenzo Dionigi
Background: The increasing use of intraoperative neuromonitoring (IONM) in thyroid surgery has revealed the need to develop new strategies for cases in which a loss of signal (LOS) occurs on the first side of a planned total thyroidectomy. Objectives: This study reviews the experience of the authors in using IONM for planned total thyroidectomy after LOS on the first thyroid lobe. The aims were to estimate the incidence of LOS on the first side of resection and to compare intraoperative strategies applied after this event...
August 2018: Laryngoscope Investigative Otolaryngology
Takahiro Fukuhara, Eriko Matsuda, Ryohei Donishi, Satoshi Koyama, Naritomo Miyake, Kazunori Fujiwara, Hiromi Takeuchi
Objective: Acoustic radiation force impulse (ARFI) imaging is a recent ultrasound elastography technique; consequently, its efficacy is not fully known. In this study, we compared ARFI imaging with conventional strain elastography (SE) and shear wave velocities (SWVs) to evaluate the utility of ARFI imaging for diagnosing thyroid nodules. Subjects and Methods: In this study we examined 233 thyroid nodules (183 benign nodules and 50 malignant nodules) isolated from human patients...
August 2018: Laryngoscope Investigative Otolaryngology
Brian Weeks, Gao Bao, Tina M Gilbert, Larry Emdur
Objectives/Hypothesis: Upper Airway Stimulation (UAS) is an FDA approved treatment option for patients with moderate-to-severe obstructive sleep apnea (OSA) who could not adhere to continuous positive airway pressure (CPAP). Previous studies have shown UAS reduced apnea-hypopnea index (AHI) in controlled clinical trials and from academic institutions. We report patient outcomes and therapy adherence of UAS in a non-academic hospital and clinic setting. Study Design: Case series of consecutive patients...
August 2018: Laryngoscope Investigative Otolaryngology
Omer J Ungar, Joseph B Nadol, Felipe Santos
Objective: To describe the histopathologic findings within the human cochlea in X-linked Alport syndrome. Study Design: Histopathologic analysis of cellular elements within the human cochlea by light microscopy. Materials and Methods: A right and a left cochleae of a man with genetically confirmed X-linked Alport syndrome was studied post-mortem. The temporal bones underwent standard processing for histologic examination. The slides were examined by light microscopy...
August 2018: Laryngoscope Investigative Otolaryngology
Scott Kramer, Kara J Vasil, Oliver F Adunka, David B Pisoni, Aaron C Moberly
Objectives: Increasing evidence suggests that hearing loss may be linked to cognitive decline, and that cochlear implantation may lead to improvements in cognition. The goal of this study was to examine the effects of severe-to-profound hearing loss and cochlear implantation in post-lingually deafened adults, compared with age-matched normal-hearing (NH) peers. Participants were tested on several non-auditory measures of cognition: working memory (WM) (digit span, object span, symbol span), non-verbal reasoning (Raven's progressive matrices), information-processing speed and inhibitory control (Stroop test), speed of phonological and lexical access (Test of Word Reading Efficiency), and verbal learning and memory (California Verbal Learning Test)...
August 2018: Laryngoscope Investigative Otolaryngology
Sophia Villiere, Ko Nakase, Richard Kollmar, Hamid Arjomandi, Jason Lazar, Krishnamurthi Sundaram, Joshua B Silverman, Michael Lucchesi, David Wlody, Mark Stewart
Background: Acute laryngospasm sufficient to cause obstructive apnea is a medical emergency that can be difficult to manage within the very short time available for establishing an airway. We have presented substantial evidence that laryngospasm-based obstructive apnea is the cause of sudden death in epilepsy, and airway management is particularly challenging during seizure activity. Objective: We sought to determine if the transtracheal delivery of a bolus of oxygen or room air below the level of an obstruction to inflate the lungs could be an effective method to prolong the time available for responders seeking to establish a stable airway, and, if so, what could be learned about optimization of delivery parameters from a rat model...
August 2018: Laryngoscope Investigative Otolaryngology
Sarah R Akkina, Roderick Y Kim, Chaz L Stucken, Melissa A Pynnonen, Carol R Bradford
Objective: To characterize the differences in the staging and treatment of patients with head and neck squamous cell carcinoma between a tertiary care center and community-based practices. Methods: This study is a retrospective chart review of 943 adult patients with head and neck squamous cell cancer presenting to a tertiary care center between 2008 and 2014 as part of the University of Michigan Head and Neck Cancer Specialized Program of Research Excellence (UM HN-SPORE) database...
August 2018: Laryngoscope Investigative Otolaryngology
Si-Young Kiessling, Martina Anja Broglie, Alex Soltermann, Gerhard Frank Huber, Sandro Johannes Stoeckli
Objectives: The aim of the study was to evaluate whether HPV associated OPSCC with tobacco exposure follows a different carcinogenic pathway compared to HPV associated OPSCC without tobacco exposure and to investigate its prognostic significance. The question was addressed with focus on components of the PI3K pathway. Methods: 184 patients with newly diagnosed OPSCC treated with curative intent were consecutively enrolled. The expression level of p16, p53, PI3K, mTOR, and PTEN was assessed by immunohistochemistry and analyzed in relation to the risk factors HPV status and tobacco exposure...
August 2018: Laryngoscope Investigative Otolaryngology
Peter A Richardson, Sagar Kansara, George G Chen, Anita Sabichi, Andrew G Sikora, Robert B Parke, Donald T Donovan, Elizabeth Chiao, Vlad C Sandulache
Objectives: Veterans with laryngeal and oropharyngeal cancer remain an understudied patient population despite a high incidence of disease and decreased survival compared to the general population. Our objective was to evaluate treatment patterns for laryngeal and oropharyngeal cancer in patients treated at one of the Veterans Health Administration's busiest cancer centers in order to generate some basic benchmarks for treatment delivery in the veteran population. Methods: We reviewed 338 patients treated at the Michael E...
August 2018: Laryngoscope Investigative Otolaryngology
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