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Laryngoscope Investigative Otolaryngology

Che-Wei Wu, Hui Sun, Guang Zhang, Hoon Yub Kim, Antonina Catalfamo, Mattia Portinari, Paolo Carcoforo, Gregory W Randolph, Young Jun Chai, Gianlorenzo Dionigi
Background: The increasing use of intraoperative neuromonitoring (IONM) in thyroid surgery has revealed the need to develop new strategies for cases in which a loss of signal (LOS) occurs on the first side of a planned total thyroidectomy. Objectives: This study reviews the experience of the authors in using IONM for planned total thyroidectomy after LOS on the first thyroid lobe. The aims were to estimate the incidence of LOS on the first side of resection and to compare intraoperative strategies applied after this event...
August 2018: Laryngoscope Investigative Otolaryngology
Takahiro Fukuhara, Eriko Matsuda, Ryohei Donishi, Satoshi Koyama, Naritomo Miyake, Kazunori Fujiwara, Hiromi Takeuchi
Objective: Acoustic radiation force impulse (ARFI) imaging is a recent ultrasound elastography technique; consequently, its efficacy is not fully known. In this study, we compared ARFI imaging with conventional strain elastography (SE) and shear wave velocities (SWVs) to evaluate the utility of ARFI imaging for diagnosing thyroid nodules. Subjects and Methods: In this study we examined 233 thyroid nodules (183 benign nodules and 50 malignant nodules) isolated from human patients...
August 2018: Laryngoscope Investigative Otolaryngology
Brian Weeks, Gao Bao, Tina M Gilbert, Larry Emdur
Objectives/Hypothesis: Upper Airway Stimulation (UAS) is an FDA approved treatment option for patients with moderate-to-severe obstructive sleep apnea (OSA) who could not adhere to continuous positive airway pressure (CPAP). Previous studies have shown UAS reduced apnea-hypopnea index (AHI) in controlled clinical trials and from academic institutions. We report patient outcomes and therapy adherence of UAS in a non-academic hospital and clinic setting. Study Design: Case series of consecutive patients...
August 2018: Laryngoscope Investigative Otolaryngology
Omer J Ungar, Joseph B Nadol, Felipe Santos
Objective: To describe the histopathologic findings within the human cochlea in X-linked Alport syndrome. Study Design: Histopathologic analysis of cellular elements within the human cochlea by light microscopy. Materials and Methods: A right and a left cochleae of a man with genetically confirmed X-linked Alport syndrome was studied post-mortem. The temporal bones underwent standard processing for histologic examination. The slides were examined by light microscopy...
August 2018: Laryngoscope Investigative Otolaryngology
Scott Kramer, Kara J Vasil, Oliver F Adunka, David B Pisoni, Aaron C Moberly
Objectives: Increasing evidence suggests that hearing loss may be linked to cognitive decline, and that cochlear implantation may lead to improvements in cognition. The goal of this study was to examine the effects of severe-to-profound hearing loss and cochlear implantation in post-lingually deafened adults, compared with age-matched normal-hearing (NH) peers. Participants were tested on several non-auditory measures of cognition: working memory (WM) (digit span, object span, symbol span), non-verbal reasoning (Raven's progressive matrices), information-processing speed and inhibitory control (Stroop test), speed of phonological and lexical access (Test of Word Reading Efficiency), and verbal learning and memory (California Verbal Learning Test)...
August 2018: Laryngoscope Investigative Otolaryngology
Sophia Villiere, Ko Nakase, Richard Kollmar, Hamid Arjomandi, Jason Lazar, Krishnamurthi Sundaram, Joshua B Silverman, Michael Lucchesi, David Wlody, Mark Stewart
Background: Acute laryngospasm sufficient to cause obstructive apnea is a medical emergency that can be difficult to manage within the very short time available for establishing an airway. We have presented substantial evidence that laryngospasm-based obstructive apnea is the cause of sudden death in epilepsy, and airway management is particularly challenging during seizure activity. Objective: We sought to determine if the transtracheal delivery of a bolus of oxygen or room air below the level of an obstruction to inflate the lungs could be an effective method to prolong the time available for responders seeking to establish a stable airway, and, if so, what could be learned about optimization of delivery parameters from a rat model...
August 2018: Laryngoscope Investigative Otolaryngology
Sarah R Akkina, Roderick Y Kim, Chaz L Stucken, Melissa A Pynnonen, Carol R Bradford
Objective: To characterize the differences in the staging and treatment of patients with head and neck squamous cell carcinoma between a tertiary care center and community-based practices. Methods: This study is a retrospective chart review of 943 adult patients with head and neck squamous cell cancer presenting to a tertiary care center between 2008 and 2014 as part of the University of Michigan Head and Neck Cancer Specialized Program of Research Excellence (UM HN-SPORE) database...
August 2018: Laryngoscope Investigative Otolaryngology
Si-Young Kiessling, Martina Anja Broglie, Alex Soltermann, Gerhard Frank Huber, Sandro Johannes Stoeckli
Objectives: The aim of the study was to evaluate whether HPV associated OPSCC with tobacco exposure follows a different carcinogenic pathway compared to HPV associated OPSCC without tobacco exposure and to investigate its prognostic significance. The question was addressed with focus on components of the PI3K pathway. Methods: 184 patients with newly diagnosed OPSCC treated with curative intent were consecutively enrolled. The expression level of p16, p53, PI3K, mTOR, and PTEN was assessed by immunohistochemistry and analyzed in relation to the risk factors HPV status and tobacco exposure...
August 2018: Laryngoscope Investigative Otolaryngology
Peter A Richardson, Sagar Kansara, George G Chen, Anita Sabichi, Andrew G Sikora, Robert B Parke, Donald T Donovan, Elizabeth Chiao, Vlad C Sandulache
Objectives: Veterans with laryngeal and oropharyngeal cancer remain an understudied patient population despite a high incidence of disease and decreased survival compared to the general population. Our objective was to evaluate treatment patterns for laryngeal and oropharyngeal cancer in patients treated at one of the Veterans Health Administration's busiest cancer centers in order to generate some basic benchmarks for treatment delivery in the veteran population. Methods: We reviewed 338 patients treated at the Michael E...
August 2018: Laryngoscope Investigative Otolaryngology
Hiroko Kuwabara, Kiyohito Yamamoto, Tetsuya Terada, Ryo Kawata, Toshitaka Nagao, Yoshinobu Hirose
Objectives: Secretory carcinoma (SC, mammary analogue secretory carcinoma) is a salivary gland tumor with ETV6-NTRK3 gene fusion, and its differential diagnosis includes acinic cell carcinoma (ACC). As hemorrhage is often seen in SC, we hypothesized that magnetic resonance imaging (MRI) and immunohistochemical analyses could distinguish SC from ACC. Study Design: Retrospective study. Methods: We used ETV6-NTRK3 gene fusion analyses to reclassify 19 parotid gland tumors that had previously been diagnosed as SC or ACC, and then investigated hemorrhage in both hematoxylin-eosin (H&E)-stained sections and MRIs, and immunohistochemical expression of S-100, mammaglobin, DOG1, and α-amylase...
August 2018: Laryngoscope Investigative Otolaryngology
Toshihiro Matsui, Takuya Okada, Kenro Kawada, Masahumi Okuda, Taichi Ogo, Yutaka Nakajima, Yuichiro Kume, Tairo Ryotokuji, Akihiro Hoshino, Yutaka Tokairin, Yasuyuki Michi, Hiroyuki Harada, Yasuaki Nakajima, Tatsuyuki Kawano
Objective: To assess the usefulness of modified esophagogastroduodenoscopy (EGD) for the detection of second primary malignancies of the esophagus or hypopharynx in patients with oral squamous cell carcinoma and determine the association between the oral lesion subsite and esophageal or hypopharyngeal lesion occurrence. Study Design: Retrospective review. Methods: In total, 166 patients with oral squamous cell carcinoma without any established symptoms of esophageal or hypopharyngeal squamous cell carcinoma underwent modified EGD based on the Valsalva maneuver and U-turn method, image-enhanced endoscopy, and chromoendoscopy using Lugol's iodine for diagnosis...
August 2018: Laryngoscope Investigative Otolaryngology
Rishie Sinha, Ricardo Correia, David Gardner, Llorenc Grau-Roma, Simone de Brot, Jonathan Hardman, Steve Morgan, Andrew Norris
Objectives: Postintubation laryngotracheal injury is common. Assessment of histopathological changes currently requires animal models. We set about developing a viable, resource effective animal model to study these effects and to develop a detailed tissue injury score. Methods: Six pigs were anesthetized using a standard regimen. We intubated the tracheas using a standard endotracheal tube modified to include optical sensors. Animals were anesthetized for a duration of two to four hours, and their lungs were ventilated using a normoxic gas mixture...
August 2018: Laryngoscope Investigative Otolaryngology
Gouri Pantvaidya, Aseem Mishra, Anuja Deshmukh, Prathamesh S Pai, Anil D'Cruz
Objective: Total thyroidectomy with or without central compartment dissection is the treatment of choice for thyroid carcinoma. Extensive dissection along the recurrent laryngeal nerve (RLN) can lead to vocal cord fixity and hoarseness even without nerve sacrifice. Recovery rates after surgery for thyroid cancers have not been well documented. The aim of the study is to analyze the incidence of vocal cord palsy (VCP) and its recovery rates in patients operated for thyroid cancers. Methodology : We performed a retrospective study on prospectively collected data in 152 thyroidectomy patients with 254 RLNs at risk...
June 2018: Laryngoscope Investigative Otolaryngology
Romaine F Johnson, Amal Isaiah
Objectives: We aimed to study laryngeal stenosis among hospitalized children in the United States from 2003-2012. We hypothesized that the prevalence of laryngeal stenosis differs by race even when controlling for age, gender, and commonly associated disease conditions. Methods: We report the results of a cross-sectional survey of hospitalized patients with laryngeal stenosis. We utilized the Kids Inpatient Database (KID) to estimate the odds of laryngeal stenosis as a function of race using regression analysis...
June 2018: Laryngoscope Investigative Otolaryngology
Allison G Ordemann, Anna Jade Hartzog, Samantha R Seals, Christopher Spankovich, Scott P Stringer
Objective: To determine if a correlation exists between weight-for-age percentile and post-tonsillectomy hemorrhage in the pediatric population. Study Design: Retrospective study. Methods: 1418 patients under the age of 15 who underwent tonsillectomy with or without adenoidectomy at a tertiary children's hospital between June 2012 and March 2015 were included in this retrospective study. Patient demographic information, operative and postoperative variables, as well as category and day of postoperative tonsillectomy bleed, if one occurred, were recorded...
June 2018: Laryngoscope Investigative Otolaryngology
Ralph Abi Hachem, Stefania Goncalves, Thomas Walker, Simon Angeli
Objective: To compare the safety and efficacy of manual and powered irrigation of the middle ear using saline or 1% baby shampoo to treat biofilm-forming bacterial middle ear infections. Background: Biofilms play a major role in recalcitrant otitis media and are challenging to treat. Many therapeutic strategies have been attempted and the role of topical therapies is still being investigated. Topical irrigation using saline or 1% baby shampoo and the use of a hydrodebrider have been investigated in biofilms involved in chronic rhinosinusitis and their role within the middle ear is yet to be determined...
June 2018: Laryngoscope Investigative Otolaryngology
Elizabeth Perkins, Meredith Rooth, Margaret Dillon, Kevin Brown
Objective: In a single-institution, FDA-approved IDE study, subjects with unilateral Meniere's disease and intractable vertigo underwent concurrent labyrinthectomy and cochlear implantation to determine speech perception, localization, and quality of life outcomes. Methods: Three subjects with unilateral Meniere's disease with normal or near-normal hearing in the contralateral ear underwent simultaneous labyrinthectomy and cochlear implantation. Sound localization, speech perception in noise and quiet, tinnitus handicap index, and quality of life measures were evaluated at 1, 3, and 6 months after implant activation...
June 2018: Laryngoscope Investigative Otolaryngology
Laura Rozenblum-Beddok, Benjamin Verillaud, Frédéric Paycha, Pierre Vironneau, Mukedaisi Abulizi, Abdel Benada, Tumatarii Cross, Ghada El-Deeb, Nicolas Vodovar, Ilana Peretti, Philippe Herman, Laure Sarda-Mantel
Objective: Skull base osteomyelitis (SBO) is a rare but life-threatening disease observed in elderly diabetic patients, with high risk of recurrence and difficult therapeutic management. The diagnosis is ascertained from a set of clinical, biological, and imaging findings. CT and MRI allow initial diagnosis, but are not accurate to affirm healing at the end of therapy. 99mTc-HMPAO-Leucocyte Scintigraphy (LS) is highly sensitive and specific for the detection of infection. The aim of this study was to evaluate LS i) for initial diagnosis, and ii) to confirm healing at the end of antibiotherapy in SBO...
June 2018: Laryngoscope Investigative Otolaryngology
Benedicte Falkenberg-Jensen, Ketil R Heimdal, Hans Erik Høgevold, Greg E Jablonski, Bernt J Due-Tønnessen, Einar Hopp
Objectives: To present nine patients with an abnormal widened bony Eustachian tube running anteriorly in the skull base through the sphenoid bone. Methods: Patients with a particular anomaly in the bony Eustachian tube incidentally found on CT examinations were registered consecutively over a period of four years. Results: Nine patients had the anomaly, eight unilaterally and one bilaterally. All our patients had additional anomalies involving the outer, middle, and/or inner ear...
June 2018: Laryngoscope Investigative Otolaryngology
Robert J Ruben
Objective: To access the long-term outcomes of children implanted during most sensitive period for language development. Study design: Literature review. Method: An initial PubMed search was carried out using the search terms language development and cochlear implant resulted in 1149 citations. A second search was carried out on the initial citations using the criterion of implantation in the period of birth to 24 months, which identified 386 articles...
June 2018: Laryngoscope Investigative Otolaryngology
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