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Open Access Rheumatology: Research and Reviews

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https://www.readbyqxmd.com/read/29138606/mortality-in-italian-patients-with-rheumatoid-arthritis-evidence-for-a-low-mortality-rate-from-cancer-and-infections-in-patients-followed-up-at-a-tertiary-center
#1
Daniela Iacono, Serena Fasano, Virginia D'Abrosca, Ilenia Pantano, Gabriele Valentini
Objectives: Mortality in patients with rheumatoid arthritis (RA) has never been investigated in Italy. This study is devoted to investigating all the distinct causes of mortality in Italian RA patients. Methods: Clinical charts of patients consecutively admitted to an Italian tertiary center, from January 1, 2008 to December 31, 2014, were reviewed. Mortality rates (incidence mortality rate [IMR] and standardized mortality rate [SMR]) and causes of death as assessed at December 31, 2015, were registered...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29089788/adalimumab-impact-on-fatigue-measured-by-facit-f-a-study-of-rheumatoid-arthritis-patients-in-saudi-arabia
#2
Nahed Janoudi, Narges Omran, Waleed Hussain, Hanan Al-Osaimi, Matouqa Baamer, Muhammad Irfanullah Siddiqui, Omar Fathaldin, Hani Almoallim
OBJECTIVE: The objective of the study was to assess the effectiveness of adalimumab as a treatment for fatigue in patients with rheumatoid arthritis (RA). METHODS: Fatigue was monitored in patients with RA who were already on an adalimumab treatment regimen. Fatigue, general well-being, comorbidities, and disease activity were measured at baseline and ~8, 16, and 24 weeks, thereafter. RESULTS: Significant reductions in fatigue scores and disease activity were observed from baseline to 6 months after...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/29026341/benefits-of-different-postoperative-treatments-in-patients-undergoing-knee-arthroscopic-debridement
#3
Cesáreo Trueba Vasavilbaso, Carlos David Rosas Bello, Erla Medina López, Maria Pilar Coronel Granado, José Mario Navarrete Álvarez, Cesáreo Angel Trueba Davalillo, Félix Isaac Gil Orbezo
PURPOSE: To assess the effectiveness of viscosupplementation or platelet-rich plasma (PRP), compared to standard care, for pain relief after knee arthroscopic debridement in patients with meniscal pathology and osteoarthritis (OA), under normal clinical practice conditions. PATIENTS AND METHODS: We conducted a prospective, randomized, evaluator-blind, pilot study. After arthroscopy, patients were randomized to receive 1) five injections of HA1 (Suprahyal(®)/Adant(®)); 2) four injections of HA2 (Orthovisc(®)); 3) three injections of HA3 (Synvisc(®)); 4) a single injection of PRP (GPS™ II); or 5) standard care (control)...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28979169/severe-neuropsychiatric-systemic-lupus-erythematosus-successfully-treated-with-rituximab-an-alternative-to-standard-of-care
#4
Elisabetta Chessa, Matteo Piga, Alberto Floris, Alessandro Mathieu, Alberto Cauli
Demyelinating syndrome secondary to systemic lupus erythematosus (DS-SLE) is a rare encephalomyelitis burden with a high risk of disability and death. We report on a 49-year-old Caucasian woman with systemic lupus erythematosus (SLE) complicated by severe cognitive dysfunction, brainstem disease, cranial nerve palsies, weakness and numbness in limbs and multiple discrete magnetic resonance imaging (MRI) areas of damage within the white matter of semioval centers, temporal lobe, external capsule, claustrum, subinsular regions and midbrain...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28860878/ozonated-autohemotherapy-modulates-the-serum-levels-of-inflammatory-cytokines-in-gouty-patients
#5
Lian-Yun Li, Ruo-Lan Ma, Liqin Du, An-Shi Wu
OBJECTIVES: Ozonated autohemotherapy (O3-AHT) has been used to effectively treat gout, but the underlying therapeutic mechanisms remain unknown. In this study, as an initial effort to understand the therapeutic mechanisms of O3-AHT, we aim to examine the effect of O3-AHT on serum inflammatory cytokine levels in gouty patients. PATIENTS AND METHODS: Three groups of patients and healthy subjects were recruited, including the gouty (n=10), hyperuricemia (n=10), and healthy control (n=11) groups...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28860877/maintenance-of-the-paraspinal-muscles-may-protect-against-radiographic-knee-osteoarthritis
#6
Koichiro Azuma, Yasushi Sera, Takuma Shinjo, Michiyo Takayama, Eisuke Shiomi, Suketaka Momoshima, Yasushi Iwao, Hiroyuki Ishida, Hideo Matsumoto
BACKGROUND: Knee osteoarthritis (OA) is an increasing health problem worldwide. So far, only obesity and quadriceps weakness are identified as modifiable risk factors for knee OA. Core muscle strengthening is becoming increasingly popular among older adults because of its ability to enhance the activities of daily living during old age. This study investigated the associations of the size and quality of the abdominal trunk muscles with radiographic knee osteoarthritis (RKOA). METHODS: From 2012 to 2016, data were collected from 146 males and 135 females (age 63...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28814904/the-journey-of-rheumatoid-arthritis-patients-a-review-of-reported-lag-times-from-the-onset-of-symptoms
#7
REVIEW
Alaa S Barhamain, Rami F Magliah, Mohammad H Shaheen, Shurooq F Munassar, Ayman M Falemban, Mohammed M Alshareef, Hani M Almoallim
BACKGROUND: Even after achieving tremendous advances in diagnosis and treatment of rheumatoid arthritis (RA), many of the patients undergo delays in diagnosis and initiation of treatment, which leads to worsening of the condition and poor prognosis. OBJECTIVE: The objective of this study was to perform a literature review to quantify the lag times in diagnosis and treatment of RA and study the reported factors associated with it. METHODS: The authors searched literature published until September 2016 in electronic full-text and abstract databases and hand-searched the suitable articles...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28790870/repository-corticotropin-injection-as-adjunctive-therapy-in-patients-with-rheumatoid-arthritis-who-have-failed-previous-therapies-with-at-least-three-different-modes-of-action
#8
Theresa Gillis, Megan Crane, Carly Hinkle, Nathan Wei
OBJECTIVE: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action. METHOD: In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28744167/muckle-wells-syndrome-clinical-perspectives
#9
REVIEW
Tu-Anh Tran
Muckle-Wells syndrome (MWS) is a rare autoinflammatory disorder. It is due to NLRP3 gene mutations, responsible for excessive caspase-1 activation and interleukin 1β processing. MWS is the intermediate phenotype of severity of cryopyrin-associated periodic syndrome. Urticarial rash, conjunctivitis, recurrent fever, arthralgia, and fatigue are the main clinical manifestations of MWS. Yet, sensorineural hearing loss and renal amyloidosis can occur after long term evolution. Patients' quality of life has been drastically improved with the advent of IL-1 inhibitors...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28652830/clinical-and-serological-characteristics-of-ecuadorian-patients-with-rheumatoid-arthritis
#10
Carlos Ríos, Génessis Maldonado, Carlos Paredes, Christian Ferro, Mario Moreno, Claudia Vera, Sara Vargas, Wendy Calapaqui, Carlos Vallejo
BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, wherein late diagnosis and treatment leads to deformities and disability. OBJECTIVE: The aim of the study was to assess and describe the clinical and immunological characteristics, activity status of the disease, and functional capacity in a cohort of Ecuadorian patients with RA. METHODS: This is a cross-sectional, descriptive study conducted on a population of patients with prediagnosed RA from public and private Ecuadorian rheumatology clinics...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28615978/clinical-characteristics-and-outcomes-of-cancer-patients-with-post-chemotherapy-arthritis-a-retrospective-case-series-report
#11
Hani Almoallim, Sultana Abdulaziz, Eilaf Fallatah, Haya Alhazmi, Nuha Meraiani, Tuqa Bazuhair, Mohammed Mansour, Anan Tayeb, Omar Fathaldin
OBJECTIVE: The objective of this report was to describe the demographics, clinical characteristics and outcomes of patients with cancer presenting with arthritis following chemotherapy in Jeddah, Saudi Arabia. PATIENTS AND METHODS: This is a retrospective case series report. We included any patient ≥18 years of age with an established diagnosis of cancer who had received standard therapeutic intervention and was subsequently diagnosed with arthritis after developing rheumatic symptoms either during or after treatment...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28546775/psychological-well-being-among-us-adults-with-arthritis-and-the-unmet-need-for-mental-health-care
#12
Laura E Straub, Miriam G Cisternas
PURPOSE: Mental health conditions can increase the risk of disability among adults with arthritis. The objective of this analysis was to compare the prevalence of serious psychological distress (SPD), depression, and anxiety among US adults with arthritis vs. those without; characterize adults with arthritis with and without SPD; and determine correlates of seeing a mental health professional during the year for adults with arthritis and SPD. MATERIALS AND METHODS: Cross-sectional analysis of adults in the 2011-2013 National Health Interview Survey...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28503078/variations-in-the-clinical-practice-of-physicians-managing-takayasu-arteritis-a-nationwide-survey
#13
Lillian Barra, Patrick Liang, Susanne M Benseler, David A Cabral, Aurore Fifi-Mah, Yueyang Li, Nataliya Milman, Marinka Twilt, Elaine Yacyshyn, Christian Pagnoux
OBJECTIVE: Takayasu arteritis (TAK) is a large vessel vasculitis that predominately affects young women and can cause severe ischemic complications. Given the rarity of TAK, the management of this condition is challenging. We aim to describe current rheumatologist practices for the management of TAK and identify discrepancies and gaps in knowledge. METHODS: An online survey (developed by the Canadian Vasculitis Network and approved by the Canadian Rheumatology Association) containing 48 questions with regard to the diagnosis, monitoring and treatment of TAK was distributed to 495 Canadian adult and pediatric rheu-matologists by email...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28490909/determining-early-referral-criteria-for-patients-with-suspected-inflammatory-arthritis-presenting-to-primary-care-physicians-a-cross-sectional-study
#14
Hani Almoallim, Nahid Janoudi, Suzan M Attar, Mohammed Garout, Shereen Algohary, Muhammad Irfanullah Siddiqui, Hanan Alosaimi, Ashraf Ibrahim, Amira Badokhon, Zaki Algasemi
OBJECTIVE: Early diagnosis and initiation of treatment for inflammatory arthritis can greatly improve patient outcome. We aimed to provide standardized and validated criteria for use by primary care physicians (PCPs) in the identification of individuals requiring referral to a rheumatologist. PATIENTS AND METHODS: We analyzed the predictive value of a wide variety of demographic variables, patient-reported complaints, physical examination results, and biomarkers in order to identify the most useful factors for indicating a requirement for referral...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28435338/recommendations-for-optimizing-methotrexate-treatment-for-patients-with-rheumatoid-arthritis
#15
REVIEW
Alfonso E Bello, Elizabeth L Perkins, Randy Jay, Petros Efthimiou
Methotrexate (MTX) remains the cornerstone therapy for patients with rheumatoid arthritis (RA), with well-established safety and efficacy profiles and support in international guidelines. Clinical and radiologic results indicate benefits of MTX monotherapy and combination with other agents, yet patients may not receive optimal dosing, duration, or route of administration to maximize their response to this drug. This review highlights best practices for MTX use in RA patients. First, to improve the response to oral MTX, a high initial dose should be administered followed by rapid titration...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28392718/single-arm-open-label-study-of-durolane-nasha-nonanimal-hyaluronic-acid-for-the-treatment-of-osteoarthritis-of-the-thumb
#16
Eloisa Velasco, Mª Victoria Ribera, Joan Pi
INTRODUCTION: Osteoarthritis of the trapeziometacarpal (TMC) joint of the thumb - also known as rhizarthrosis - is painful and has a significant impact on quality of life. Intra-articular injection of hyaluronic acid may potentially meet the need for effective, minimally invasive intervention in patients not responding adequately to initial treatment. We aimed to confirm the safety and effectiveness of viscosupplementation with Durolane (NASHA nonanimal hyaluronic acid) in rhizarthrosis...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28352206/color-duplex-ultrasonography-findings-of-temporal-arteries-in-a-case-of-giant-cell-arteritis-role-in-diagnosis-and-follow-up
#17
Antonella Laria, Alfredo Lurati, Magda Scarpellini
Giant cell arteritis (GCA) is a systemic autoimmune disease that affects medium- and large-sized arteries. The diagnostic gold standard is the temporal artery biopsy, but it has limited sensitivity and some difficulties in reproducibility. Color duplex ultrasonography is a noninvasive, reproducible, and inexpensive method for diagnosis of temporal arteries involvement (temporal arteritis [TA]) in GCA with high sensitivity and specificity. We present the ultrasound findings at baseline and during follow-up in a case of TA in a patient with GCA...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28331377/management-of-systemic-lupus-erythematosus-during-pregnancy-challenges-and-solutions
#18
REVIEW
Caroline L Knight, Catherine Nelson-Piercy
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal-neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Effective prepregnancy risk assessment and counseling includes exploration of factors for poor pregnancy outcome, discussion of risks, and appropriate planning for pregnancy, with consideration of discussion of relative contraindications to pregnancy...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28331376/long-term-safety-and-efficacy-of-biosimilar-infliximab-among-patients-with-inflammatory-arthritis-switched-from-reference-product
#19
Abuelmagd Abdalla, Niamh Byrne, Richard Conway, Thomas Walsh, Geraldine Mannion, Michael Hanly, Miriam O'Sullivan, Ann Maria Curran, John J Carey
PURPOSE: To evaluate the efficacy and safety of the biosimilar infliximab in adult patients with inflammatory arthritis switched from reference product in our center. PATIENTS AND METHODS: In April 2014, patients attending our rheumatology service for infliximab infusions were switched from reference product to the biosimilar infliximab following consent and hospital approval. RESULTS: Around 34 patients with inflammatory arthritis were switched from reference product to biosimilar infliximab in 2014: 50% female, mean age 55 years (standard deviation=12...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28280401/review-of-the-treatment-of-psoriatic-arthritis-with-biological-agents-choice-of-drug-for-initial-therapy-and-switch-therapy-for-non-responders
#20
REVIEW
Salvatore D'Angelo, Giuseppina Tramontano, Michele Gilio, Pietro Leccese, Ignazio Olivieri
Psoriatic arthritis (PsA) is a heterogeneous chronic inflammatory disease with a broad clinical spectrum and variable course. It can involve musculoskeletal structures as well as skin, nails, eyes, and gut. The management of PsA has changed tremendously in the last decade, thanks to an earlier diagnosis, an advancement in pharmacological therapies, and a wider application of a multidisciplinary approach. The commercialization of tumor necrosis factor inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, and infliximab) as well as interleukin (IL)-12/23 (ustekinumab) and IL-17 (secukinumab) inhibitors is representative of a revolution in the treatment of PsA...
2017: Open Access Rheumatology: Research and Reviews
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