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Pragmatic and Observational Research

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https://www.readbyqxmd.com/read/30147391/real-life-treatment-of-rhinitis-in-australia-a-historical-cohort-study-of-prescription-and-over-the-counter-therapies-for-patients-with-and-without-additional-respiratory-disease
#1
David B Price, Pete K Smith, Richard John Harvey, A Simon Carney, Vicky Kritikos, Sinthia Z Bosnic-Anticevich, Louise Christian, Derek Skinner, Victoria Carter, Alice Ms Durieux
Background: The aim of the study was to explore rhinitis therapy purchases in different Australian regions for patients with and without additional respiratory disease, using both doctor's prescriptions and over-the-counter (OTC) medications. Patients and methods: It was a historical cohort study of pharmacy-related claims that included prescription or OTC rhinitis therapy, with or without asthma/COPD therapy, from January 2013 to December 2014. Results: Overall, 4,247,193 prescription and OTC rhinitis treatments were purchased from 909 pharmacies over a calendar year; the majority were single-therapy purchases for rhinitis only patients...
2018: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/30127653/performance-of-database-derived-severe-exacerbations-and-asthma-control-measures-in-asthma-responsiveness-and-predictive-utility-in-a-uk-primary-care-database-with-linked-questionnaire-data
#2
Gene Colice, Alison Chisholm, Alexandra L Dima, Helen K Reddel, Annie Burden, Richard J Martin, Guy Brusselle, Todor A Popov, Julie von Ziegenweidt, David B Price
Background: Observational research is essential to evaluate the real-life effectiveness of asthma treatments and can now make use of outcomes derived from electronic medical records. Aim: The aim of this study was to investigate the utility of several database outcome measures in asthma. Methods: This study identified cohorts of patients with active asthma from a UK primary care database - Optimum Patient Care Research Database - approximately 10% of which was prospectively supplemented with questionnaire data...
2018: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/30022864/factors-associated-with-early-cardiac-complications-following-transcatheter-aortic-valve-implantation-with-transapical-approach
#3
Vasileios Patris, Konstantinos Giakoumidakis, Mihalis Argiriou, Katerina K Naka, Efstratios Apostolakis, Mark Field, Manoj Kuduvalli, Aung Oo, Stavros Siminelakis
Purpose: To estimate the incidence of postprocedural early cardiac complications among patients undergoing transcatheter aortic valve implantation, through transapical approach (TA-TAVI), and to identify factors independently associated with the occurrence of them. Patients and methods: A retrospective cohort study of 90 patients, who had undergone TA-TAVI in a tertiary hospital of Liverpool, UK, during a 5-year period (September 2008-October 2013), was conducted...
2018: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29773957/perioperative-predictors-of-delirium-and-incidence-factors-in-adult-patients-post-cardiac-surgery
#4
Stavros Theologou, Konstantinos Giakoumidakis, Christos Charitos
Background: Delirium is a quite common complication in adult patients post-cardiac surgery. The purpose of our study was to identify perioperative characteristics and also focus on incidence factors that could predict delirium in the cardiac surgery intensive care unit (CICU) postoperatively. Methods: We conducted a prospective study of 179 consecutive patients, who underwent open-heart surgical operation and were admitted to the CICU of a general tertiary hospital in Athens, Greece...
2018: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29750067/real-world-effectiveness-and-safety-of-oral-anticoagulation-strategies-in-atrial-fibrillation-a-cohort-study-based-on-a-german-claims-dataset
#5
Sabrina Mueller, Antje Groth, Stefan G Spitzer, Anja Schramm, Andreas Pfaff, Ulf Maywald
Objective: To compare the real-world effectiveness and safety of non-vitamin-K-antagonist oral anticoagulant (NOAC) treatment in atrial fibrillation (AF) patients with a vitamin-K-antagonist (VKA)-based treatment. Methods: This was a retrospective analysis of an anonymized claims dataset from 3 German health insurance funds covering the period from January 01, 2010 to June 30, 2014, with a minimum observation time of 12 months. All continuously insured patients with at least 2 outpatient AF diagnoses and/or 1 inpatient respective diagnosis who received at least 1 outpatient prescription of a NOAC or VKA were included...
2018: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29238240/the-effect-of-dpp-4-inhibitors-on-asthma-control-an-administrative-database-study-to-evaluate-a-potential-pathophysiological-relationship
#6
Gene Colice, David Price, Maria Gerhardsson de Verdier, Karma Rabon-Stith, Christopher Ambrose, Katherine Cappell, Debra E Irwin, Paul Juneau, Anna Vlahiotis
Rationale: DPP-4 may regulate immunological pathways implicated in asthma. Assessing whether DPP-4 inhibitor (DPP-4i) use might affect asthma control is clinically important because DPP-4i use in type 2 diabetes mellitus management (T2DM) is increasing. This study evaluated associations between DPP-4i use and asthma control. Methods: This was a retrospective, observational, matched cohort study using administrative claims in the MarketScan® Commercial Claims and Encounters (Commercial) and Medicare Supplemental and Coordination of Benefits (Medicare Supplemental) databases...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29138615/factors-associated-with-late-anc-initiation-among-pregnant-women-in-select-public-health-centers-of-addis-ababa-ethiopia-unmatched-case-control-study-design
#7
Kahasse Gebrekidan, Alemayehu Worku
Background: Although Ethiopia has shown remarkable achievements in reducing maternal mortality in the last 10 years, the prevalence of late antenatal care (ANC) initiation is still high in the country. Objective: The primary purpose of this study was to identify the factors related to late ANC initiation among pregnant women in selected public health centers in Addis Ababa, Ethiopia. Subjects and methods: A total of 402 pregnant women (cases=134, controls=268) were recruited using multistage sampling...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29066939/prevalence-of-neuro-musculoskeletal-pain-and-dysfunction-in-open-heart-surgical-patients-preoperatively-and-at-6-and-12-weeks-postoperatively-a-prospective-longitudinal-observation-study
#8
R Nicole Bellet, Rhonda L Lamb, Tonya D Gould, Harold J Bartlett
Chronic neuro-musculoskeletal pain is an important complication of open-heart surgery (OHS). To better understand the development and natural course of neuro-musculoskeletal pain in the immediate post-OHS period, this prospective longitudinal study assessed the prevalence and degree of pain and shoulder disability, and areas of pain pre- and post-OHS. Usual medical, nursing, and physiotherapy care was provided including early extubation, education, walking, sitting out of bed, and upper, lower limb, and trunk exercises from day 1 post-operation...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29042828/predictors-of-sedentary-status-in-overweight-and-obese-patients-with-multiple-chronic-conditions-a-cohort-study
#9
Mark H Joven, Ivana T Croghan, Stephanie M Quigg, Jon O Ebbert, Paul Y Takahashi
PURPOSE: Walking may improve health in obese patients with multimorbidity. We aimed to identify predictors associated with achieving <5000 steps per day after 4 months. PATIENTS AND METHODS: We conducted a cohort study of 125 adult patients with a body mass index >25 kg/m2 and ≥7 comorbidities. We evaluated potential predictors for <5000 steps per day using logistic regression and adjusting for age >65 years and sex. RESULTS: The mean (range) age was 63...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29033627/impact-of-primary-care-exercise-referral-schemes-on-the-health-of-patients-with-obesity
#10
Helen M Parretti, Suzanne E Bartington, Tim Badcock, Lucy Hughes, Joan L Duda, Kate Jolly
Primary care exercise referral schemes (ERSs) are a potentially useful setting to promote physical activity (PA). It is not established, however, whether interventions to increase PA, such as ERSs, have differing health outcomes according to the participants' body mass index (BMI). This paper summarizes evidence for the impact of primary care ERSs on the health of people with obesity and reports findings of a reanalysis of the EMPOWER study, providing the first data to report differential outcomes of ERSs by BMI category...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29033626/the-presence-of-obesity-paradox-in-greek-patients-with-chronic-heart-failure
#11
Efstratios Vlaras, Konstantinos Giakoumidakis, Nikolaos V Fotos, Anastasia A Chatziefstratiou, Hero Brokalaki
PURPOSE: To investigate the effect of body mass index (BMI) values on 1- and 2-year mortality rates in patients with chronic heart failure (HF). PATIENTS AND METHODS: We conducted a retrospective cohort study of 112 patients with confirmed HF who visited the HF outpatient unit of a tertiary hospital of Athens, Greece, during a 5-month period (December 2012 - April 2013). These patients were assigned to four groups based on their BMI category. Data collection was carried out through a review of the medical patient records and the filling in of a structured questionnaire, including information on the demographic and clinical patient variables...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/29033625/the-salford-lung-study-a-pioneering-comparative-effectiveness-approach-to-copd-and-asthma-in-clinical-trials
#12
REVIEW
Timothy E Albertson, Susan Murin, Mark E Sutter, James A Chenoweth
The Salford Lung Study (SLS) of patients with asthma and chronic obstructive pulmonary disease (COPD) is a practical, community-based, randomized, open-label pragmatic study on the efficacy and safety of the once-daily dry powder inhaler that combines the inhaled corticosteroid fluticasone furoate (FF) with the long-acting beta2 agonist vilanterol (VI). The asthma component of the SLS is not yet reported but the COPD component, done over a 12-month period, found a statistically significant 8.4% reduction in COPD exacerbations when compared to usual care...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28919833/conventional-culture-versus-nucleic-acid-amplification-tests-for-screening-of-urethral-neisseria-gonorrhea-infection-among-asymptomatic-men-who-have-sex-with-men
#13
Jiratha Budkaew, Bandit Chumworathayi, Chamsai Pientong, Tipaya Ekalaksananan
BACKGROUND: Many methods are used to detect urethral Neisseria gonorrhea (NG) infection among asymptomatic men who have sex with men (MSM). The objective of this study was to define the performance of conventional culture compared to real-time polymerase chain reaction (PCR) for diagnosis of asymptomatic urethral gonorrhea among MSM. METHODS: In this cross-sectional study, 147 clinical specimens for NG testing from asymptomatic participants were evaluated. MSM >18 years old who consented to undergo urethral swab and collection of urine samples from two clinics (one was the sexually transmitted diseases (STDs) mobile clinic and the second was the antiretroviral clinic) located in Khon Kaen, Thailand, were recruited...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28919832/seasonal-patterns-of-oral-antihistamine-and-intranasal-corticosteroid-purchases-from-australian-community-pharmacies-a-retrospective-observational-study
#14
A Simon Carney, David B Price, Pete K Smith, Richard Harvey, Vicky Kritikos, Sinthia Z Bosnic-Anticevich, Louise Christian, Derek A Skinner, Victoria Carter, Alice Ms Durieux
PURPOSE: To explore patterns in the purchase of prescription and over-the-counter (OTC) oral antihistamines (OAHs) and intranasal corticosteroids (INCSs) by patients, from pharmacies in different geographical regions of Australia. PATIENTS AND METHODS: Retrospective observational study using a database containing anonymous pharmacy transaction data from 20.0% of the pharmacies in Australia that link doctor prescriptions and OTC information. Pharmacy purchases of at least one prescription or OTC rhinitis treatment during 2013 and 2014 were assessed...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28894396/a-validation-of-clinical-data-captured-from-a-novel-cancer-care-quality-program-directly-integrated-with-administrative-claims-data
#15
David M Kern, John J Barron, Bingcao Wu, Alex Ganetsky, Vincent J Willey, Ralph A Quimbo, Michael J Fisch, Joseph Singer, Ann Nguyen, Ronac Mamtani
BACKGROUND: Data from a Cancer Care Quality Program are directly integrated with administrative claims data to provide a level of clinical detail not available in claims-based studies, and referred to as the HealthCore Integrated Research Environment (HIRE)-Oncology data. This study evaluated the validity of the HIRE-Oncology data compared with medical records of breast, lung, and colorectal cancer patients. METHODS: Data elements included cancer type, stage, histology (lung only), and biomarkers...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28761388/coronary-stents-and-vascular-response-to-implantation-literature-review
#16
REVIEW
Marta Francesca Brancati, Francesco Burzotta, Carlo Trani, Ornella Leonzi, Claudio Cuccia, Filippo Crea
Drug-eluting stents (DESs) have minimized the limitations of bare-metal stents (BMSs) after percutaneous coronary interventions. Nevertheless, serious concerns remain about possible late complications of stenting, such as stent thrombosis (ST) and in-stent restenosis (ISR), although the introduction of second-generation DESs seems to have softened the phenomenon, compared to the first-generation ones. ST is a potentially catastrophic event, which has been markedly reduced by optimization of stent implantation, novel stent designs, and dual antiplatelet therapy...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28761387/abortion-an-increasing-public-health-concern-in-ecuador-a-10-year-population-based-analysis
#17
Esteban Ortiz-Prado, Katherine Simbaña, Lenin Gómez, Anna M Stewart-Ibarra, Lisa Scott, Gabriel Cevallos-Sierra
OBJECTIVES: To describe the epidemiology of abortion in Ecuador from 2004 to 2014 and compare the prevalence between the public and the private health care systems. METHODS: This is a cross-sectional analysis of the overall mortality and morbidity rate due to abortion in Ecuador, based on public health records and other government databases. RESULTS: From 2004 to 2014, a total of 431,614 spontaneous abortions, miscarriage and other types of abortions were registered in Ecuador...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28740444/effective-deployment-of-technology-supported-management-of-chronic-respiratory-conditions-a-call-for-stakeholder-engagement
#18
Richard W Costello, Alexandra L Dima, Dermot Ryan, R Andrew McIvor, Kay Boycott, Alison Chisholm, David Price, John D Blakey
BACKGROUND: Healthcare systems are under increasing strain, predominantly due to chronic non-communicable diseases. Connected healthcare technologies are becoming ever more capable and their components cheaper. These innovations could facilitate both self-management and more efficient use of healthcare resources for common respiratory diseases such as asthma and chronic obstructive pulmonary disease. However, newer technologies can only facilitate major changes in practice, and cannot accomplish them in isolation...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28615987/stroke-rates-before-and-after-ablation-of-atrial-fibrillation-and-in-propensity-matched-controls-in-the-uk
#19
Julian We Jarman, Tina D Hunter, Wajid Hussain, Jamie L March, Tom Wong, Vias Markides
BACKGROUND: We sought to determine whether catheter ablation of atrial fibrillation (AF) is associated with reduced occurrence of ischemic cerebrovascular events. METHODS AND RESULTS: Using routinely collected hospital data, ablation patients were matched to two control cohorts via direct and propensity score matching. A total of 4,991 ablation patients were matched 1:1 to general AF controls with no ablation, and 5,407 ablation patients were similarly matched to controls who underwent cardioversion...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28615986/mortality-stroke-and-heart-failure-in-atrial-fibrillation-cohorts-after-ablation-versus-propensity-matched-cohorts
#20
Julian We Jarman, Tina D Hunter, Wajid Hussain, Jamie L March, Tom Wong, Vias Markides
BACKGROUND: We sought to determine from key clinical outcomes whether catheter ablation of atrial fibrillation (AF) is associated with increased survival. METHODS AND RESULTS: Using routinely collected hospital data, ablation patients were matched to two control cohorts using direct and propensity score methodology. Four thousand nine hundred ninety-one ablation patients were matched 1:1 with general AF controls without ablation. Five thousand four hundred seven ablation patients were similarly matched to controls who underwent cardioversion...
2017: Pragmatic and Observational Research
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