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Pharmaceutical Nanotechnology

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https://www.readbyqxmd.com/read/30227827/drug-delivery-for-cancer-immunotherapy-and-vaccines
#1
Cole J Batty, Pamela Tiet, Eric M Bachelder, Kristy M Ainslie
Cancer cells are able to avoid immune surveillance and exploit the immune system to grow and metastasize. With the development of nano- and micro-particles, there has been a growing number of immunotherapy delivery systems developed to elicit innate and adaptive immune responses to eradicate cancer cells. This can be accomplished by training resident immune cells to recognize and eliminate cells with tumor-associated antigens or by providing external stimuli to enhance tumor cell apoptosis in the immunosuppressive tumor microenvironment (TME)...
September 18, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30210010/skin-targeting-of-oxiconazole-nitrate-loaded-nanostructured-lipid-carrier-gel-for-fungal-infections
#2
Hemantkumar Arvind Ranpise, Kishor Namdev Gujar, Dyandevi Mathure, Pooja Pandurang Satpute, Rajendra Awasthi, Kamal Dua, Jyotsana R Madan
The progression of fungal infections can be rapid and serious due to compromising with immune function. They may cause liver damage, affect estrogen levels or may cause allergic reactions. Oxyconazole nitrate (OCXN) is a broad spectrum commonly used antifungal drug. It acts by erogosterol biosynthesis inhibition, which causes lysis of fungal cell membrane because of changes in both membrane integrity and fluidity and direct membrane damage of fungal cells. However, its poor water solubility and short half-life (3-5 h) limit its applications...
September 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30101725/transethosomes-of-econazole-nitrate-for-transdermal-delivery-development-in-vitro-characterization-and-ex-vivo-assessment
#3
Shivani Verma, Puneet Utreja
BACKGROUND: Transdermal drug delivery is an attractive approach for both local and systemic therapeutics of various diseases. Transdermal drug delivery systems show various advantages like reduction of local irritation, prevention of first pass hepatic metabolism, and bioavailability enhancement of bioactive molecules over conventional drug delivery systems. OBJECTIVES: The main objective of the present research work was to develop and characterize (in-vitro and ex-vivo) econazole nitrate loaded transethosomes and their comparison with marketed cream of econazole nitrate [Ecoderm, Brown and Burk Pharmaceutical (Pvt...
August 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30101724/preparation-of-chitosan-okra-nanoparticles-optimization-and-evaluation-as-mucoadhesive-nasal-drug-delivery-system
#4
Vivekjot Brar, Gurpreet Kaur
OBJECTIVE: Esculin loaded nanoparticles for nasal delivery were prepared by ionic gelation technique using okra gum and chitosan Method: The preparation of nanoparticles was optimized using Box-Behnken experimental design employing particle size, entrapment efficiency and zeta potential as dependable variables. Okra concentration, chitosan concentration, pH and stirring speed were taken as independent variables. RESULTS: The formulations were found to depict particle size in the range of 294...
August 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29984674/characterization-of-polymeric-nanoparticle-dispersions-for-biomedical-applications-size-surface-charge-and-stability
#5
C Fornaguera, C Solans
In the last decades, nanoparticles intended for biomedical applications have gained increased attention due to the advantages they represent among the current diagnostic and therapeutic methods. However, the translation of nanomaterials laboratory results to human therapies is limited, mainly due to incomplete characterization of nanosystem properties, before preclinical studies. In this context, this review aims to summarize the main physicochemical characterization techniques of nanoparticles in a liquid dispersion, required in their design steps; which is of utmost importance for successful applications...
July 6, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29956641/anti-biofilm-activity-against-gram-positive-bacteria-by-biologically-synthesized-silver-nanoparticles-using-curcuma-longa
#6
Suresh P Kamble, Keshav D Shinde
OBJECTIVE: To assess the biofilm inhibition activity of biosynthesized silver nanoparticles (AgNPs) using Curcuma longa. METHODS: Characterizations of these biogenic nanoparticles were done by UV-Vis spectroscopy, TEM, EDX and nanoparticles tracking analyzer. Antibiofilm activity of AgNPs against S. aureus and S. pneumoniae was carried out by 96 well plate method. Further the combined effect of AgNPs with the antibiotic was studied against S. aureus and S. pneumoniae...
June 29, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29938624/interfacial-phenomenon-based-biocompatible-alginate-chitosan-nanoparticles-containing-isoniazid-and-pyrazinamide
#7
Kalpana, Harinath Dwivedi
BACKGROUND: Tuberculosis (TB) is one of the major health challenge in the world. The current treatment of TB needs daily administration of combined drug therapy for six or more months. Sometime non-adherence and less bioavailability from current therapy develops multidrug resistance, as a result, high dose requirement and subsequent intolerable toxicity are seen. Therefore, nanotechnology gained special attention as it has potential to improve patient compliance, bioavailability and reduction in dosing frequency...
June 25, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29886841/phyto-fabrication-of-zno-nanoparticles-using-piper-betel-aqueous-extract-and-evaluation-of-its-applicability-in-dentistry
#8
P Shubha, K Byrappa, K Namratha, Jit Chaterjee, M S Mustak
BACKGROUND: Facile, environmental friendly synthesis of metal oxide nanoparticles is of paramount importance when its biological applications are considered. OBJECTIVE: Current study reports phyto-fabrication of Zinc oxide nanoparticles using aqueous extract of Piper betel leaves as stabilizing and capping agent using co-precipitation method. RESULTS: P betel synthesized ZnO nanoparticles (PZnO) was characterized using Powder X-ray diffraction, UV-Visible spectroscopy, scanning electron microscopy and dynamic light scattering...
June 10, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29546839/co-delivery-of-doxorubicin-and-verapamil-for-treating-multidrug-resistant-cancer-cells
#9
Jacob B Williams, Clara G Buchanan, William G Pitt
Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Co-delivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug resistant cancer cells. Objective - Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective at killing multidrug resistant cancer cells compared to conventional drug delivery...
March 16, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30207210/codelivery-of-doxorubicin-and-verapamil-for-treating-multidrug-resistant-cancer-cells
#10
Jacob B Williams, Clara M Buchanan, William G Pitt
BACKGROUND: Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Codelivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug-resistant cancer cells. OBJECTIVE: Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective in killing multidrug resistant cancer cells compared to conventional drug delivery...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30207209/editorial
#11
EDITORIAL
Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29886842/lipid-nanoparticles-a-novel-approach-for-brain-targeting
#12
Ravi Shankar, Monika Joshi, Kamla Pathak
BACKGROUND: Brain is a delicate organ, separated from general circulation and is characterized by the presence of relatively impermeable Blood Brain Barrier (BBB). The BBB maintains homeostasis in the brain thus restricting the entrance of foreign bodies and several molecules from reaching the brain. As a result several promising molecules do not reach the target site and fail to produce in vivo response. Nevertheless, lipid nanoparticles are taken up readily by the brain because of their lipophilic nature...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29866028/exploring-therapeutic-potential-of-nanocarrier-systems-against-breast-cancer
#13
Lalit Kumar, Ashish Baldi, Shivani Verma, Puneet Utreja
BACKGROUND: Breast cancer is the most widely occurring non-cutaneous cancer in women. Treatment options available for breast cancer are limited and there are a number of toxicity concerns associated with them. Therefore, nanocarrier based approaches have been explored for breast cancer treatment. Nanocarriers implemented for breast cancer treatment are nanoliposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, dendrimers, and protein nanocages...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29788899/topical-nanostructured-lipid-carrier-based-hydrogel-of-mometasone-furoate-for-the-treatment-of-psoriasis
#14
Navjot Kaur, Kusha Sharma, Neena Bedi
OBJECTIVE: The aim of the present study was to develop and evaluate nanostructured lipid carrier based topical hydrogel of mometasone furoate for the treatment of psoriasis. METHOD: Drug loaded NLCs were successfully developed by microemulsion technique. Pseudo ternary phase diagrams were constructed using different combinations of surfactant and co-surfactants to study the microemulsion existence range. Different compositions were selected from the phase diagram showing maximum microemulsion region and were converted into NLCs by dilution in water (1:20)...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29697357/editorial-emerging-bio-inspired-and-bio-compatible-nanomaterials-in-21st-century
#15
EDITORIAL
Saravanan Muthupandian, Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29683102/solid-lipid-particles-as-drug-carriers-effects-of-particle-preparation-methods-and-lipid-excipients-on-particle-characteristics
#16
Cintia Kieffer Gamboa, Ranoda Samir, Chengyu Wu, Huiling Mu
BACKGROUND: Oral delivery of biopharmaceuticals is limited by the absorption barriers in the Gastrointestinal Tract (GIT) such as low permeability across the biological membranes and the enzymatic degradation by proteases. In this study, lipid-based drug delivery systems were proposed to overcome these obstacles. OBJECTIVE: The aim of this study was to evaluate the effect of particle preparation methods and excipients on the characteristics of Solid Lipid Microparticles (SLM) and Solid Lipid Nanoparticles (SLN)...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29510658/radiosensitizing-effect-of-cerium-oxide-nanoparticles-on-human-leukemia-cells
#17
Azadeh Montazeri, Zohreh Zal, Arash Ghasemi, Hooman Yazdannejat, Hossein Asgarian-Omran, Seyed Jalal Hosseinimehr
BACKGROUND: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of Cerium oxide Nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 μg/ml) and exposed to Ionizing Radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29510657/tangential-flow-filtration-technique-an-overview-on-nanomedicine-applications
#18
Teresa Musumeci, Antonio Leonardi, Angela Bonaccorso, Rosario Pignatello, Giovanni Puglisi
Purification is a key step for different types of approaches, ranging from food, biotechnology to pharmaceutical fields. In biotechnology, tangential flow filtration (TFF) allows obtaining the separation of different components of cells without instability phenomena. In the food industry, TFF ensures the removal of contaminants or other substances that negatively affect visual appearance, organoleptic attributes, nutritional value and/or safety of ailments. In the pharmaceutical area, purification is also an important and necessary step controlling the quality of final product...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29424324/nano-medicine-as-a-newly-emerging-approach-to-combat-human-immunodeficiency-virus-hiv
#19
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29424323/topical-delivery-of-erythromycin-through-cubosomes-for-acne
#20
Sana Khan, Poorva Jain, Sourabh Jain, Richa Jain, Saurabh Bhargava, Aakanchha Jain
BACKGROUND: Topical delivery is an attractive route for local and systemic treatment. The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms. OBJECTIVE: The aim of present work was to prepare and characterized erythromycin encapsulated cubosomes using different concentrations of glyceryl monooleate and poloxamer 407 by the emulsification method...
2018: Pharmaceutical Nanotechnology
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