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Pharmaceutical Nanotechnology

C Fornaguera, C Solans
In the last decades, nanoparticles intended for biomedical applications have gained increased attention due to the advantages they represent among the current diagnostic and therapeutic methods. However, the translation of nanomaterials laboratory results to human therapies is limited, mainly due to incomplete characterization of nanosystem properties, before preclinical studies. In this context, this review aims to summarize the main physicochemical characterization techniques of nanoparticles in a liquid dispersion, required in their design steps; which is of utmost importance for successful applications...
July 6, 2018: Pharmaceutical Nanotechnology
Suresh P Kamble, Keshav D Shinde
OBJECTIVE: To assess the biofilm inhibition activity of biosynthesized silver nanoparticles (AgNPs) using Curcuma longa. METHODS: Characterizations of these biogenic nanoparticles were done by UV-Vis spectroscopy, TEM, EDX and nanoparticles tracking analyzer. Antibiofilm activity of AgNPs against S. aureus and S. pneumoniae was carried out by 96 well plate method. Further the combined effect of AgNPs with the antibiotic was studied against S. aureus and S. pneumoniae...
June 29, 2018: Pharmaceutical Nanotechnology
Kalpana Kushwaha, Harinath Dwivedi
BACKGROUND: Tuberculosis (TB) is one of major health challenge in the world. The current treatment of TB needs daily administration of combined drug therapy for six or more months. Sometime non adherence, less bioavailability from current therapy develops multidrug resistance, as a result high dose requirement and subsequent intolerable toxicity is seen. Therefore, nanotechnology gained special attention as it has potential to improve patient compliance, bioavailability and reduction in dosing frequency...
June 25, 2018: Pharmaceutical Nanotechnology
Ravi Shankar, Monika Joshi, Kamla Pathak
BACKGROUND: Brain is a delicate organ, separated from general circulation and is characterized by the presence of relatively impermeable Blood Brain Barrier (BBB). The BBB maintains homeostasis in the brain thus restricting the entrance of foreign bodies and several molecules from reaching the brain. As a result several promising molecules do not reach the target site and fail to produce in vivo response. Nevertheless, lipid nanoparticles are taken up readily by the brain because of their lipophilic nature...
June 10, 2018: Pharmaceutical Nanotechnology
P Shubha, K Byrappa, K Namratha, Jit Chaterjee, M S Mustak
BACKGROUND: Facile, environmental friendly synthesis of metal oxide nanoparticles is of paramount importance when its biological applications are considered. OBJECTIVE: Current study reports phyto-fabrication of Zinc oxide nanoparticles using aqueous extract of Piper betel leaves as stabilizing and capping agent using co-precipitation method. RESULTS: P betel synthesized ZnO nanoparticles (PZnO) was characterized using Powder X-ray diffraction, UV-Visible spectroscopy, scanning electron microscopy and dynamic light scattering...
June 10, 2018: Pharmaceutical Nanotechnology
Lalit Kumar, Ashish Baldi, Shivani Verma, Puneet Utreja
BACKGROUND: Breast cancer is most widely occurring non-cutaneous cancer in women. Treatment options available for breast cancer are limited and there are a number of toxicity concerns associated with them. Therefore, nanocarrier based approaches have been explored for breast cancer treatment. Nanocarriers implemented for breast cancer treatment are nanoliposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, dendrimers, and protein nanocages...
June 3, 2018: Pharmaceutical Nanotechnology
Navjot Kaur, Kusha Sharma, Neena Bedi
OBJECTIVE: The aim of the present study was to develop and evaluate nanostructured lipid carrier based topical hydrogel of mometasone furoate for the treatment of psoriasis. METHODS: Drug loaded NLCs were successfully developed by microemulsion technique. Pseudo ternary phase diagrams were constructed using different combinations of surfactant and co-surfactants to study the microemulsion existence range. Different compositions were selected from the phase diagram showing maximum microemulsion region and were converted into NLCs by dilution in water (1:20)...
May 22, 2018: Pharmaceutical Nanotechnology
Cintia Kieffer Gamboa, Ranoda Samir, Chengyu Wu, Huiling Mu
BACKGROUND: Oral delivery of biopharmaceuticals is limited by the absorption barriers in the gastrointestinal tract (GIT) such as low permeability across the biological membranes and the enzymatic degradation by proteases. In this study, lipid based drug delivery systems were proposed to overcome these obstacles. OBJECTIVE: The aim of this study was to evaluate the effect of particle preparation methods and excipients on the characteristics of solid lipid microparticles (SLM) and solid lipid nanoparticles (SLN)...
April 20, 2018: Pharmaceutical Nanotechnology
Jacob B Williams, Clara G Buchanan, William G Pitt
Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Co-delivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug resistant cancer cells. Objective - Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective at killing multidrug resistant cancer cells compared to conventional drug delivery...
March 16, 2018: Pharmaceutical Nanotechnology
Azadeh Montazeri, Zohreh Zal, Arash Ghasemi, Hooman Yazdannejat, Hossein Asgarian-Omran, Seyed Jalal Hosseinimehr
: Background: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of cerium oxide nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 µg/ml) and exposed to ionizing radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells...
March 6, 2018: Pharmaceutical Nanotechnology
Saravanan Muthupandian, Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
Teresa Musumeci, Antonio Leonardi, Angela Bonaccorso, Rosario Pignatello, Giovanni Puglisi
Purification is a key step for different types of approaches, ranging from food, biotechnology to pharmaceutical fields. In biotechnology, tangential flow filtration (TFF) allows obtaining the separation of different components of cells without instability phenomena. In the food industry, TFF ensures the removal of contaminants or other substances that negatively affect visual appearance, organoleptic attributes, nutritional value and/or safety of ailments. In the pharmaceutical area, purification is also an important and necessary step controlling the quality of final product...
2018: Pharmaceutical Nanotechnology
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
2018: Pharmaceutical Nanotechnology
Sana Khan, Poorva Jain, Sourabh Jain, Richa Jain, Saurabh Bhargava, Aakanchha Jain
BACKGROUND: Topical delivery is an attractive route for local and systemic treatment. The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms. OBJECTIVE: The aim of present work was to prepare and characterized erythromycin encapsulated cubosomes using different concentrations of glyceryl monooleate and poloxamer 407 by the emulsification method...
2018: Pharmaceutical Nanotechnology
Dyandevi Mathure, Jyotsana R Madan, Kishore N Gujar, Ashok Tupsamundre, Hemant A Ranpise, Kamal Dua
BACKGROUND: Buspirone Hydrochloride is an anxiolytic agent and serotonin receptor agonist belonging to azaspirodecanedione class of compounds used in the treatment of anxiety disorders. It has short half-life (2-3h) and low oral bioavailability (4%) due to extensive first pass metabolism. OBJECTIVE: The nasal mucosa has several advantages viz., large surface area, porous endothelial membrane, high blood flow, avoidance of first-pass metabolism and ready accessibility that lead to faster and higher drug absorption...
2018: Pharmaceutical Nanotechnology
V R Ranjitha, V R Ravishankar
BACKGROUND: Selenium nanoparticles (SeNPs) have gained significant importance because of its bioavailability, least toxicity, its interaction with proteins and its biocompatibility. OBJECTIVE: In the present study, the extracellular synthesis of SeNPs was carried out by using culture supernatant of Streptomyces griseoruber, an Actinomycetes member isolated from the soil and cytotoxicity was tested on HT-29 cell line. METHODS: Culture supernatant was mixed with 1mM sodium selenite for the biosynthesis of SeNPs...
2018: Pharmaceutical Nanotechnology
Balu Ranganathan, Charles Miller, Anthony Sinskey
BACKGROUND: Bioengineering has come of ages by setting up spare parts manufacturing units to be used in human body such as invasive implants and interventional controlled drug delivery in vivo systems. As a matter of fact patients on basis of their fiscal strength have the option to undergo prophylactic tactical manoeuvre for longer life spans. In this sphere of invasive implants, biocompatible polymer implants are a state of the art cutting edge technology with outstanding innovations leading to number of very successful start-up companies with a plethora of patent portfolios...
2018: Pharmaceutical Nanotechnology
Mohd Aslam Saifi, Wahid Khan, Chandraiah Godugu
BACKGROUND: The rapid progress in the application of different types of nanoparticles in various biomedical applications resulted in substantial increase in the use of these materials. The special physicochemical properties like small size and increased surface area offered by nanoparticles may pose unexpected toxicologic threats despite of offering promising biological effects. OBJECTIVE: The intended as well as unintended exposure of nanoparticles to humans is a major challenge for the expanding field of nanoparticle therapy...
2018: Pharmaceutical Nanotechnology
Ashkan Hedayati, Sina Ghafurzadeh Yazdi, Pouya Dehghankelishadi, Nika Bahari Javan, Hamid Akbari, Farid A Dorkoosh
BACKGROUND: Multiple applications of antipsychotic agents are the main obstacle upon treatment of schizophrenia. Due to behavioral abnormalities, low compliance is observed in the most of psychotic patients. Designing of new drug delivery systems to overcome compliance problem seems to be necessary. In situ forming implants are a suitable choice for delivery of antipsychotic agents due to easy administration process and sustained release kinetics. OBJECTIVE: In this study, a novel poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) based nano-porous in situ implant system is developed for delivery of aripiprazole...
May 22, 2017: Pharmaceutical Nanotechnology
Farzin Hadizadeh, Jamal Shamsara
BACKGROUND: Dissipative particle dynamics (DPD) is a simulation method that one of its applications is in the field of pharmaceutical science and drug delivery. OBJECTIVE: DPD is employed to study morphology and some other characteristics of polymeric nano-micelles. Two systems were considered in this study: system A which includes curcumin, Polycaprolactone (PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel, Polylactic acid (PLA), PEG and water beads...
May 22, 2017: Pharmaceutical Nanotechnology
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