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Pharmaceutical Nanotechnology

Cintia Kieffer Gamboa, Ranoda Samir, Chengyu Wu, Huiling Mu
BACKGROUND: Oral delivery of biopharmaceuticals is limited by the absorption barriers in the gastrointestinal tract (GIT) such as low permeability across the biological membranes and the enzymatic degradation by proteases. In this study, lipid based drug delivery systems were proposed to overcome these obstacles. OBJECTIVE: The aim of this study was to evaluate the effect of particle preparation methods and excipients on the characteristics of solid lipid microparticles (SLM) and solid lipid nanoparticles (SLN)...
April 20, 2018: Pharmaceutical Nanotechnology
Jacob B Williams, Clara G Buchanan, William G Pitt
Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Co-delivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug resistant cancer cells. Objective - Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective at killing multidrug resistant cancer cells compared to conventional drug delivery...
March 16, 2018: Pharmaceutical Nanotechnology
Azadeh Montazeri, Zohreh Zal, Arash Ghasemi, Hooman Yazdannejat, Hossein Asgarian-Omran, Seyed Jalal Hosseinimehr
: Background: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment. OBJECTIVE: The aim of this study was to evaluate the radiosensitizing effect of cerium oxide nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60). METHOD: HL-60 cells were treated with CNPs at different concentrations (10-100 µg/ml) and exposed to ionizing radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells...
March 6, 2018: Pharmaceutical Nanotechnology
Saravanan Muthupandian, Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
Teresa Musumeci, Antonio Leonardi, Angela Bonaccorso, Rosario Pignatello, Giovanni Puglisi
Purification is a key step for different types of approaches, ranging from food, biotechnology to pharmaceutical fields. In biotechnology, tangential flow filtration (TFF) allows obtaining the separation of different components of cells without instability phenomena. In the food industry, TFF ensures the removal of contaminants or other substances that negatively affect visual appearance, organoleptic attributes, nutritional value and/or safety of ailments. In the pharmaceutical area, purification is also an important and necessary step controlling the quality of final product...
2018: Pharmaceutical Nanotechnology
Muthupandian Saravanan, Tsehaye Asmalash, Atsebaha Gebrekidan, Dawit Gebreegziabiher, Tadele Araya, Haftamu Hilekiros, Hamed Barabadi, Kumaresan Ramanathan
BACKGROUND: Human Immuno deficiency Virus (HIV) infection has attained pandemic level due to its complexity on both the HIV infection cycle and on the targets for drug delivery. This limits medication and consequently requires prominent and promising drug delivery systems to be invented. Notably, various nanomaterial have been studied to enhance effective delivery of the antiretroviral drugs for HIV prevention, diagnosis and cure. Some of these nanomaterials are liposomes, dendrimers, inorganic nanoparticles (NPs), polymeric micelles, natural and synthetic polymers...
2018: Pharmaceutical Nanotechnology
Sana Khan, Poorva Jain, Sourabh Jain, Richa Jain, Saurabh Bhargava, Aakanchha Jain
BACKGROUND: Topical delivery is an attractive route for local and systemic treatment. The novel topical application has many advantages like averting the GI-irritation, preventing the metabolism of drugs in the liver and increasing the bioavailability of the drug over the conventional dosage forms. OBJECTIVE: The aim of present work was to prepare and characterized erythromycin encapsulated cubosomes using different concentrations of glyceryl monooleate and poloxamer 407 by the emulsification method...
2018: Pharmaceutical Nanotechnology
Dyandevi Mathure, Jyotsana R Madan, Kishore N Gujar, Ashok Tupsamundre, Hemant A Ranpise, Kamal Dua
BACKGROUND: Buspirone Hydrochloride is an anxiolytic agent and serotonin receptor agonist belonging to azaspirodecanedione class of compounds used in the treatment of anxiety disorders. It has short half-life (2-3h) and low oral bioavailability (4%) due to extensive first pass metabolism. OBJECTIVE: The nasal mucosa has several advantages viz., large surface area, porous endothelial membrane, high blood flow, avoidance of first-pass metabolism and ready accessibility that lead to faster and higher drug absorption...
2018: Pharmaceutical Nanotechnology
V R Ranjitha, Ravishankar Rai Vittal
In the present study, the extracellular synthesis of Selenium nanoparticles (SeNPs) was carried out by using culture supernatant of Streptomyces griseoruber, an Actinomycetes member isolated from the soil. Bioreduction of SeNPs was confirmed by UV-Visible spectrophotometer that showed the peak at 575 nm. XRD pattern confirmed the non-crystalline or amorphous nature of the synthesised SeNPs. FTIR spectra revealed the possible functional group that is responsible for mediating the SeNPs formation. Size and distribution of the biosynthesised SeNPs were analysed by HR-TEM that showed the formation of particle size in the range of 100-250nm...
November 13, 2017: Pharmaceutical Nanotechnology
Bindu Dhiman, Divtrannum Bhalla, Anju Dhiman, Sapna Saini
Nanotechnology has gained a great deal of public interest due to the needs and applications of nanomaterials in many areas of human endeavours such as industry, agriculture, business, medicine, public health amongst many others. Nanotechnology includes the integration of these nanoscale structures into larger material components and systems, keeping the control and construction of new and improved materials at the nanoscale. Biological nanoparticles are mainly developed for drug delivery systems as an alternative to liposomal technology, in order to overcome the problems related to the stability of these vesicles in biological fluids and during the storage...
November 8, 2017: Pharmaceutical Nanotechnology
Balu Ranganathan, Charles Miller, Anthony Sinskey
Bioengineering has come of ages by setting up spare parts manufacturing units to be used in human body such as invasive implants and interventional controlled drug delivery in vivo systems. As a matter of fact patients on basis of their fiscal strength have the option of undergoing prophylactic tactical manoeuvre for longevity. In this sphere of invasive implants, biocompatible polymer implants are a state of the art cutting edge technology with outstanding innovations leading to number of very successful start-up companies with a plethora of patent portfolios...
October 23, 2017: Pharmaceutical Nanotechnology
Mohd Aslam Saifi, Wahid Khan, Chandraiah Godugu
BACKGROUND: The rapid progress in the application of different types of nanoparticles in various biomedical applications resulted in substantial increase in use of these materials. The special physicochemical properties like small size and increased surface area offered by nanoparticles may pose unexpected toxicological threats despite of offering promising biological effects. OBJECTIVE: The intended as well as unintended exposure of nanoparticles to humans is a major challenge for the expanding field of nanoparticle therapy...
October 23, 2017: Pharmaceutical Nanotechnology
Minakshi Gupta, Harish Dureja, Rakesh Kumar Marwaha
BACKGROUND: There is rapidly growing interest in the development of nanoparticle drug delivery mainly for anticancer drugs as it promises to solve several problems related to anticancer drugs like poor water solubility, low therapeutic index, nonspecific distribution and higher systemic toxicity, etc. OBJECTIVE: The objective of the study was to investigate the effect of various critical variables like, concentration of chitosan, concentration of sodium tripolyphosphate (STPP) and volume of STPP on various characteristics of gefitinib loaded nanoparticles...
October 4, 2017: Pharmaceutical Nanotechnology
Deepti Pandita, Neelam Kumari, Viney Lather
The current investigation involves the development of a thermodynamically stable and dilutable self-nanoemulsifying drug delivery system (SNEDDS) for tolbutamide, a poorly water soluble hypoglycemic drug, in order to achieve higher water solubility and enhanced dissolution rate which in turn improves its oral bioavailability. Pseudo-ternary phase diagrams suggested the suitability of oleic acid (lipid), Tween 20 (surfactant) and PEG 400 (co-surfactant) for developing the SNEEDS formulations. The optimal SNEDDS formulation having mean globule diameter, viscosity, polydispersity value of 58...
September 15, 2017: Pharmaceutical Nanotechnology
Vikash Kumar, Hema Chaudhary, Geeta Aggarwal
The aim of study was to design, statistically optimize and characterize Granisetron HCl loaded transfersomal gel for transdermal delivery, in order to overcome the side effects associated with oral delivery. A response surface methodology experimental design was applied for the optimization of transfersomes, using Box-Behnken experimental design. Phospholipid-90G, sodium deoxycholate and sonication time, each at three levels, were selected as independent variables, and while entrapment efficiency, vesicle size and transdermal flux were identified as dependent variables...
September 15, 2017: Pharmaceutical Nanotechnology
Deepak Kaushik, Ajay Saroha, Parijat Pandey
In the present investigation, chitosan nanoparticles containing timolol maleate (TM) were developed by using Box- Behnken design for ocular delivery. Ionic gelation method was to be used for the development of Timolol loaded chitosan nanoparticles by usinga cross linking agent, sodium tripolyphosphate (NaTPP). The formulation design was successfully utilized for the study of the effect of three critical parameters like theconcentration of chitosan (X1), the concentration of NaTPP (X2), and the volume of NaTPP (X3)on the drug release from the prepared nanoparticles...
August 27, 2017: Pharmaceutical Nanotechnology
Kamal Dua
BACKGROUND: Respiratory tract being a non-invasive route of drug administration is gaining massive attention in the present time to achieve both local and the systemic effects. In order to achieve effective therapeutic effects of a drug in the pulmonary region, it requires challenging barriers like mucociliary clearance and uptake by macrophages. An effective drug delivery system delivers the therapeutically active moieties at the right time, rate and in a reproducible manner to target sites for the effectively the human illnesses...
August 7, 2017: Pharmaceutical Nanotechnology
Dinesh Kumar Chellappan, Philip Michael Hansbro, Kamal Dua, Alan Hsu, Gaurav Gupta, Zhao Yin Ng, Jin-Yin Wong, Jestin Chellian, Jithendra Panneerselvam
BACKGROUND: Vesicular systems like nanotechnology and liposomes are gaining tremendous attention lately in the field of respiratory diseases. These formulations enhance bioavailability of the drug candidate, which could be achieved through a novel drug delivery mechanism. Moreover, the therapeutic potential achieved through these systems are highly controllable over long durations of time providing better efficacy and patient compliance. METHODS: We have collated and summarized various recent attempts made to develop different controlled release drug delivery systems containing curcumin which would be of great interest for herbal, formulation and biological scientists...
August 7, 2017: Pharmaceutical Nanotechnology
Ashkan Hedayati, Sina Ghafurzadeh Yazdi, Pouya Dehghankelishadi, Nika Bahari Javan, Hamid Akbari, Farid A Dorkoosh
BACKGROUND: Multiple applications of antipsychotic agents are the main obstacle upon treatment of schizophrenia. Due to behavioral abnormalities, low compliance is observed in the most of psychotic patients. Designing of new drug delivery systems to overcome compliance problem seems to be necessary. In situ forming implants are a suitable choice for delivery of antipsychotic agents due to easy administration process and sustained release kinetics. OBJECTIVE: In this study, a novel poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) based nano-porous in situ implant system is developed for delivery of aripiprazole...
May 22, 2017: Pharmaceutical Nanotechnology
Farzin Hadizadeh, Jamal Shamsara
BACKGROUND: Dissipative particle dynamics (DPD) is a simulation method that one of its applications is in the field of pharmaceutical science and drug delivery. OBJECTIVE: DPD is employed to study morphology and some other characteristics of polymeric nano-micelles. Two systems were considered in this study: system A which includes curcumin, Polycaprolactone (PCL), Polyethylene glycol (PEG) and water beads and system B which includes paclitaxel, Polylactic acid (PLA), PEG and water beads...
May 22, 2017: Pharmaceutical Nanotechnology
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