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Pharmaceutical Nanotechnology

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https://www.readbyqxmd.com/read/30394227/formulation-and-optimization-of-topical-solid-lipid-nanoparticles-based-gel-of-dapsone-using-design-of-experiment
#1
Sanjeevani Shekhar Deshkar, Shyam Gangadhar Bhalerao, Monali Shivaji Jadhav, Satish Vasudeo Shirolkar
OBJECTIVE: The present research work was designed to formulate and evaluate solid lipid nanoparticles (SLN) loaded gel of Dapsone (DS). An attempt was made to develop topical gel with better skin permeation rate. METHODS: The SLN formulations of DS were prepared by microemulsion technique and evaluated for its in vitro characteristics. The effect of DS concentration in lipid phase (X1), Gelucire:Precirol ratio (X2) and lipid:Smix ratio (X3) on entrapment efficiency (Y1) and drug release (Y2)from SLN was studied using Box-Behnken design...
November 5, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30381089/synergistic-evaluation-of-functionalized-magnetic-nanoparticles-and-antibiotics-against-staphylococcus-aureus-and-escherichia-coli
#2
Ahmad Gholami, Alireza Ebrahiminezhad, Narjeskhatoon Abootalebi, Younes Ghasemi
BACKGROUND AND OBJECTIVES: The combination of nano-metals and antibacterial agents could improve the efficacy of antibiotics against pathogens. This study suggested a combination method for increasing antibacterial and anti-biofilm activity of ampicillin and gentamicin using iron oxide nanoparticles. METHODS: Synthesis of lipoamino acid-coated IONs (LION14) were done by co-precipitation method. The LION14s were characterized by several techniques. The antimicrobial and biofilm inhibitory activities of nanoparticles at three time intervals were investigated alone and in combination with ampicillin and gentamicin against Staphylococcus aureus and Escherichia coli...
October 31, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30381088/cellular-toxicity-of-mesoporous-silica-nanoparticle-in-shsy5y-and-bm-mncs-cell
#3
Shivendra Chauhan, Geetha Manivasagam, Pravir Kumar, Rashmi K Ambasta
BACKGROUND: Mesoporous silica nanoparticles (MSNs) are emerging as one of the new and promising nanomaterials for biomedical applications, but enough investigation has not been done in the field of the biocompatibility of MSNs in vitro condition. OBJECTIVE: The present study aims to investigate the toxicity of mesoporous silica nanoparticles in BM-MNCs and SHSY5Y Cell. METHOD: The synthesis of MSN was performed and it was characterized for its size by SEM and XRD...
October 31, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30277174/animal-models-optimise-nanoparticles-for-drug-delivery-in-the-treatment-of-hepatocellular-carcinoma
#4
Zhiwen Zhang, Liu Song, Jianfeng Guo
Hepatocellular carcinoma (HCC) causes significant morbidity and high fatal outcome globally. Conventional therapeutic strategies have achieved significant improvements for HCC, but they have limitations and are far from ideal. Novel nanoparticulate drug delivery systems have recently presented great therapeutic potential for HCC. The potential for successful clinical translation of formulation strategies can only be evaluated by using appropriate and accurate pre-clinical models. This review will provide an overview of different animal models of HCC, with a particular emphasis on those applied to assess the translational potential for drug nanopharmaceutics...
October 1, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30227827/drug-delivery-for-cancer-immunotherapy-and-vaccines
#5
Cole J Batty, Pamela Tiet, Eric M Bachelder, Kristy M Ainslie
Cancer cells are able to avoid immune surveillance and exploit the immune system to grow and metastasize. With the development of nano- and micro-particles, there has been a growing number of immunotherapy delivery systems developed to elicit innate and adaptive immune responses to eradicate cancer cells. This can be accomplished by training resident immune cells to recognize and eliminate cells with tumor-associated antigens or by providing external stimuli to enhance tumor cell apoptosis in the immunosuppressive tumor microenvironment (TME)...
September 18, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30210010/skin-targeting-of-oxiconazole-nitrate-loaded-nanostructured-lipid-carrier-gel-for-fungal-infections
#6
Hemantkumar Arvind Ranpise, Kishor Namdev Gujar, Dyandevi Mathure, Pooja Pandurang Satpute, Rajendra Awasthi, Kamal Dua, Jyotsana R Madan
The progression of fungal infections can be rapid and serious due to compromising with immune function. They may cause liver damage, affect estrogen levels or may cause allergic reactions. Oxyconazole nitrate (OCXN) is a broad spectrum commonly used antifungal drug. It acts by erogosterol biosynthesis inhibition, which causes lysis of fungal cell membrane because of changes in both membrane integrity and fluidity and direct membrane damage of fungal cells. However, its poor water solubility and short half-life (3-5 h) limit its applications...
September 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30101725/transethosomes-of-econazole-nitrate-for-transdermal-delivery-development-in-vitro-characterization-and-ex-vivo-assessment
#7
Shivani Verma, Puneet Utreja
BACKGROUND: Transdermal drug delivery is an attractive approach for both local and systemic therapeutics of various diseases. Transdermal drug delivery systems show various advantages like reduction of local irritation, prevention of first pass hepatic metabolism, and bioavailability enhancement of bioactive molecules over conventional drug delivery systems. OBJECTIVES: The main objective of the present research work was to develop and characterize (in-vitro and ex-vivo) econazole nitrate loaded transethosomes and their comparison with marketed cream of econazole nitrate [Ecoderm, Brown and Burk Pharmaceutical (Pvt...
August 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30101724/preparation-of-chitosan-okra-nanoparticles-optimization-and-evaluation-as-mucoadhesive-nasal-drug-delivery-system
#8
Vivekjot Brar, Gurpreet Kaur
OBJECTIVE: Esculin loaded nanoparticles for nasal delivery were prepared by ionic gelation technique using okra gum and chitosan Method: The preparation of nanoparticles was optimized using Box-Behnken experimental design employing particle size, entrapment efficiency and zeta potential as dependable variables. Okra concentration, chitosan concentration, pH and stirring speed were taken as independent variables. RESULTS: The formulations were found to depict particle size in the range of 294...
August 13, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29984674/characterization-of-polymeric-nanoparticle-dispersions-for-biomedical-applications-size-surface-charge-and-stability
#9
C Fornaguera, C Solans
In the last decades, nanoparticles intended for biomedical applications have gained increased attention due to the advantages they represent among the current diagnostic and therapeutic methods. However, the translation of nanomaterials laboratory results to human therapies is limited, mainly due to incomplete characterization of nanosystem properties, before preclinical studies. In this context, this review aims to summarize the main physicochemical characterization techniques of nanoparticles in a liquid dispersion, required in their design steps; which is of utmost importance for successful applications...
July 6, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29956641/anti-biofilm-activity-against-gram-positive-bacteria-by-biologically-synthesized-silver-nanoparticles-using-curcuma-longa
#10
Suresh P Kamble, Keshav D Shinde
OBJECTIVE: To assess the biofilm inhibition activity of biosynthesized silver nanoparticles (AgNPs) using Curcuma longa. METHODS: Characterizations of these biogenic nanoparticles were done by UV-Vis spectroscopy, TEM, EDX and nanoparticles tracking analyzer. Antibiofilm activity of AgNPs against S. aureus and S. pneumoniae was carried out by 96 well plate method. Further the combined effect of AgNPs with the antibiotic was studied against S. aureus and S. pneumoniae...
June 29, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29938624/interfacial-phenomenon-based-biocompatible-alginate-chitosan-nanoparticles-containing-isoniazid-and-pyrazinamide
#11
Kalpana, Harinath Dwivedi
BACKGROUND: Tuberculosis (TB) is one of the major health challenge in the world. The current treatment of TB needs daily administration of combined drug therapy for six or more months. Sometime non-adherence and less bioavailability from current therapy develops multidrug resistance, as a result, high dose requirement and subsequent intolerable toxicity are seen. Therefore, nanotechnology gained special attention as it has potential to improve patient compliance, bioavailability and reduction in dosing frequency...
June 25, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29886841/phyto-fabrication-of-zno-nanoparticles-using-piper-betel-aqueous-extract-and-evaluation-of-its-applicability-in-dentistry
#12
P Shubha, K Byrappa, K Namratha, Jit Chaterjee, M S Mustak
BACKGROUND: Facile, environmental friendly synthesis of metal oxide nanoparticles is of paramount importance when its biological applications are considered. OBJECTIVE: Current study reports phyto-fabrication of Zinc oxide nanoparticles using aqueous extract of Piper betel leaves as stabilizing and capping agent using co-precipitation method. RESULTS: P betel synthesized ZnO nanoparticles (PZnO) was characterized using Powder X-ray diffraction, UV-Visible spectroscopy, scanning electron microscopy and dynamic light scattering...
June 10, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29546839/co-delivery-of-doxorubicin-and-verapamil-for-treating-multidrug-resistant-cancer-cells
#13
Jacob B Williams, Clara G Buchanan, William G Pitt
Background - Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Co-delivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug resistant cancer cells. Objective - Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective at killing multidrug resistant cancer cells compared to conventional drug delivery...
March 16, 2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30207210/codelivery-of-doxorubicin-and-verapamil-for-treating-multidrug-resistant-cancer-cells
#14
Jacob B Williams, Clara M Buchanan, William G Pitt
BACKGROUND: Patients undergoing chemotherapy can develop resistance not only to the administered drug, but also to many other unrelated types of drugs, a phenomenon known as multidrug resistance. One of the most common mechanisms of multidrug resistance is an elevated expression of drug efflux pumps. Codelivery of an efflux pump inhibitor with a chemotherapeutic can increase the killing of multidrug-resistant cancer cells. OBJECTIVE: Our hypothesis was that delivering doxorubicin directly to the cytosol of multidrug resistant cancer cells via a folate-targeted liposome loaded with a perfluoropentane emulsion droplet and doxorubicin (folated eLipoDox), along with the delivery of verapamil to block the efflux pumps will prove to be more effective in killing multidrug resistant cancer cells compared to conventional drug delivery...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/30207209/editorial
#15
EDITORIAL
Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29886842/lipid-nanoparticles-a-novel-approach-for-brain-targeting
#16
Ravi Shankar, Monika Joshi, Kamla Pathak
BACKGROUND: Brain is a delicate organ, separated from general circulation and is characterized by the presence of relatively impermeable Blood Brain Barrier (BBB). The BBB maintains homeostasis in the brain thus restricting the entrance of foreign bodies and several molecules from reaching the brain. As a result several promising molecules do not reach the target site and fail to produce in vivo response. Nevertheless, lipid nanoparticles are taken up readily by the brain because of their lipophilic nature...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29866028/exploring-therapeutic-potential-of-nanocarrier-systems-against-breast-cancer
#17
Lalit Kumar, Ashish Baldi, Shivani Verma, Puneet Utreja
BACKGROUND: Breast cancer is the most widely occurring non-cutaneous cancer in women. Treatment options available for breast cancer are limited and there are a number of toxicity concerns associated with them. Therefore, nanocarrier based approaches have been explored for breast cancer treatment. Nanocarriers implemented for breast cancer treatment are nanoliposomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, dendrimers, and protein nanocages...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29788899/topical-nanostructured-lipid-carrier-based-hydrogel-of-mometasone-furoate-for-the-treatment-of-psoriasis
#18
Navjot Kaur, Kusha Sharma, Neena Bedi
OBJECTIVE: The aim of the present study was to develop and evaluate nanostructured lipid carrier based topical hydrogel of mometasone furoate for the treatment of psoriasis. METHOD: Drug loaded NLCs were successfully developed by microemulsion technique. Pseudo ternary phase diagrams were constructed using different combinations of surfactant and co-surfactants to study the microemulsion existence range. Different compositions were selected from the phase diagram showing maximum microemulsion region and were converted into NLCs by dilution in water (1:20)...
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29697357/editorial-emerging-bio-inspired-and-bio-compatible-nanomaterials-in-21st-century
#19
EDITORIAL
Saravanan Muthupandian, Ijeoma Uchegbu
No abstract text is available yet for this article.
2018: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29683102/solid-lipid-particles-as-drug-carriers-effects-of-particle-preparation-methods-and-lipid-excipients-on-particle-characteristics
#20
Cintia Kieffer Gamboa, Ranoda Samir, Chengyu Wu, Huiling Mu
BACKGROUND: Oral delivery of biopharmaceuticals is limited by the absorption barriers in the Gastrointestinal Tract (GIT) such as low permeability across the biological membranes and the enzymatic degradation by proteases. In this study, lipid-based drug delivery systems were proposed to overcome these obstacles. OBJECTIVE: The aim of this study was to evaluate the effect of particle preparation methods and excipients on the characteristics of Solid Lipid Microparticles (SLM) and Solid Lipid Nanoparticles (SLN)...
2018: Pharmaceutical Nanotechnology
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