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European Journal of Rheumatology

Abhishek Zanwar, Latika Gupta, Ramnath Misra
No abstract text is available yet for this article.
August 2, 2018: European Journal of Rheumatology
Kerry Jobling, Hanaa Rajabally, Wan-Fai Ng
There are emerging case reports worldwide of complete heart block in adults who test positive for anti-Ro antibodies and the underlying primary Sjögren's syndrome (pSS). The association between fetal/congenital cardiac abnormalities and transplacental transfer of anti-Ro antibodies is well established; there is, however, an ongoing debate about the underlying mechanism of activity of these antibodies in the cardiac tissue. In the past, maternal cardiac tissue was believed to be resistant to these pathogenic effects...
July 20, 2018: European Journal of Rheumatology
Sedat Yılmaz, Emre Tekgöz, Muhammet Çınar
There is no established treatment protocol for amyloid-A (AA) amyloidosis secondary to Familial Mediterranean Fever (FMF). Recently, we reported the efficacy of tocilizumab in 11 amyloidosis cases associated with FMF. In 2 patients of 11, we discontinued the tocilizumab administeration owing to the normalization of amyloidosis-related symptoms, but proteinuria re-occurred eventually. Fortunately, the patients responded to tocilizumab re-treatment. This led us to conclude that physicians should not stop the treatment, even in patients with normalized proteinuria levels...
July 20, 2018: European Journal of Rheumatology
Fernando Sommerfleck, Emilce Schneeberger, Gustavo Citera
OBJECTIVE: The objective of this study was to compare the frequency of comorbidities among patients with ax-SpA in the general population and to evaluate the impact of these comorbidities on the functional status and quality of life. METHODS: Patients with ax-SpA fulfilling the modified New York 1984 criteria for Ankylosing Spondylitis (AS) and/or Assessment of SpondyloArthritis International Society (ASAS ) 2009 criteria for patients with ax-SpA belonging to the ESPAXIA cohort ("Estudio de eSPondiloartritis Axial Irep Argentina") were included...
June 22, 2018: European Journal of Rheumatology
Francisco Javier Domínguez Díez
Treatment with anti-tumor necrosis factor alpha (anti-TNF α) drugs may lead to demyelinating polyneuropathies. Here, we present the case of a patient with rheumatic disease who developed sensory polyneuropathy probably related to anti-TNF α drugs. The patient was diagnosed with undifferentiated arthritis during treatment with weekly injection of golimumab. She presented a progressive picture of paresthesia of all four limbs, with distal and symmetrical predominance, associated with mild dysarthria and universal areflexia, except for the Achilles reflex...
June 22, 2018: European Journal of Rheumatology
Emre Tekgöz, Egemen Akıncıoğlu, Muhammet Çınar, Sedat Yılmaz
Exogenous ochronosis is characterized by hyperpigmented skin lesions that arise in association with local suppression of homogentisic acid oxidase enzyme. Although it generally develops in association with topical application of chemical agents, it can occasionally develop in association with antimalarial drugs. Here we present the case of a patient with rheumatoid arthritis who developed hyperpigmentation on the face and neck regions during hydroxychloroquine treatment. Hydroxychloroquine is being widely used in rheumatology practice, and cutaneous hyperpigmentation may develop as an adverse effect...
June 22, 2018: European Journal of Rheumatology
Didem Saygın, Abrahim U Syed, Careen Y Lowder, Sunil Srivastava, Juan J Maya, Rula A Hajj-Ali
OBJECTIVE: Hidradenitis suppurativa (HS) is an inflammatory skin condition that can cause profound morbidity. Patients can present with recurrent nodules, sinus tract formation, abscesses, and/or scarring, mainly affecting the intertriginous areas. Case reports have documented the coexistence of HS and inflammatory eye disease (IED). Herein, we aimed to assess the types of IED associated with HS and the outcomes of IED treatment in patients with HS. METHODS: All the cases with a diagnosis of HS and any IED were identified...
June 22, 2018: European Journal of Rheumatology
Theodros Solomon-Tsegaye, Edward L Treadwell, Reginald Obi, Mariavittoria Pitzalis
Up to 10% of systemic lupus erythematosus (SLE) cases are drug-induced; hence, they are called drug-induced lupus syndrome (DILS). Antinuclear antibody (ANA) should be present to diagnose SLE and DILS. ANA-negative lupus is very rare; therefore, it presents a diagnostic challenge. In the medical literature, two cases of ANA-negative hydralazine-induced lupus syndrome (HILS) have been described within the last year. Here, we present the third such case of HILS with negative ANA serology in a patient who developed considerable pericardial effusion...
June 20, 2018: European Journal of Rheumatology
Charles Raine, Benjamin Canning, Jonathan Marks, Simon Donnelly, Voon Ong, Hasan Tahir
In this paper, we describe a case of a male patient with anti-U1RNP positive limited cutaneous systemic sclerosis/rheumatoid arthritis overlap syndrome, who presented acutely with rapidly progressive digital ischemia, which lead to extensive gangrene. Management with conventional vasodilator therapy was unsuccessful. There were constitutional symptoms and a marked inflammatory response in the absence of evidence of infection, implying a component of vasculitis underlying the presentation. Treatment with immunosuppression and intravenous immunoglobulin led to resolution of the inflammatory process with no further progression of tissue necrosis...
June 20, 2018: European Journal of Rheumatology
Aniruddh Kapoor, Philip Vaidyan, Basmah Jalil, Chitra Upaluri
Anti-synthetase syndrome (AS) is a heterogeneous group of systemic autoimmune diseases associated with anti-aminoacyl-transfer RNA synthetases. These inflammatory myopathies present with a constellation of symptoms including myositis, arthritis, Raynaud's phenomenon, and interstitial lung disease (ILD). We present a novel case of a 44-year-old female, who presented with Anti-OJ AS with severe myopathy and rhabdomyolysis without evidence of ILD, which, in our literature review and to the best of our knowledge, has not been previously reported...
June 20, 2018: European Journal of Rheumatology
Muhammad K Nisar
No abstract text is available yet for this article.
April 19, 2018: European Journal of Rheumatology
Nicholas G Kounis, Ioanna Koniari, Dimitrios Velissaris, George Soufras, George Hahalis
No abstract text is available yet for this article.
April 19, 2018: European Journal of Rheumatology
Bünyamin Kısacık, Mustafa Erkut Önder, Mehmet Sayarlıoğlu, Ahmet Mesut Onat
Granulomatosis with polyangiitis (GPA) is a primary systemic vasculitis characterized by granulomatous inflammation. Arthritis in GPA is most commonly associated with large joints, particularly the knees and ankles; however, symmetrical polyarthritis of small joints has been rarely reported in literature. Here, we describe retrospective analysis of six patients with GPA showing initial symptom of symmetrical polyarthritis who were followed-up by three different rheumatology departments. Male sex, anti-cyclic citrulinated peptide negativity, and early arthritis period are important clues for GPA...
April 19, 2018: European Journal of Rheumatology
Ashish Agarwal, Ankur K Jindal, Sandesh Guleria, Tarun K Jain, Bhagwant R Mittal, Deepti Suri
No abstract text is available yet for this article.
April 2, 2018: European Journal of Rheumatology
Andrew B Lemmey, Thomas J Wilkinson, Celine M Perkins, Luke A Nixon, Fazal Sheikh, Jeremy G Jones, Yasmeen A Ahmad, Thomas D O'brien
OBJECTIVE: Adverse changes in body composition, specifically decreased muscle mass (MM) and increased fat mass, characterize rheumatoid arthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA following a single intramuscular (IM) corticosteroid (CS) injection to treat a disease flare. The aim of the current study is to determine whether this apparent iatrogenic effect of IM CS is typical, i...
April 2, 2018: European Journal of Rheumatology
Uta Erdbrügger, Jan T Kielstein, Kerstin Westman, Jennie Z Ma, Wenjun Xin, Stephanie M Bode-Böger, Mȧrten Segelmark, Niels Rasmussen, Kirsten De Groot
OBJECTIVE: Endothelial dysfunction, increased cardiovascular events (CVE), and accelerated atherosclerosis have been described in patients with small vessel vasculitis and collagen vascular disease. Identifying predictors of cardiovascular risk will help to optimize short- and long-term care of patients with vasculitis. The present study investigates the predictive role of the endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and its stereoisomer symmetric dimethylarginine (SDMA) for cardiovascular risk, all-cause mortality, and renal function in patients with anti-neutrophil-cytoplasmic antibodies-associated small vessel vasculitis (AASV) subjected to standardized treatment regimens in four European Vasculitis Study Group trials representing all stages of renal disease...
April 2, 2018: European Journal of Rheumatology
Anita Laloo, Vasileios C Kyttaris
Septic arthritis in patients with systemic lupus erythematosus (SLE) is rare and is reported in only 3% of patients. Contrary to lupus arthritis, which tends to be polyarticular in nature, primarily involving the small joints of the hands, septic arthritis is commonly monoarticular. Here, we present an unusual case of a patient with SLE, who developed oligoarticular inflammatory arthritis caused by a rare native joint pathogen Staphylococcus lugdunensis. The infection resulted in extensive early damage to the joints involved, highlighting the need for early diagnosis and treatment...
March 2, 2018: European Journal of Rheumatology
Juliana Brandão Pinto Carneiro, Taíssa Pinto de Souza, Mauro Martins Lippi, Felipe Augusto Silva Gama, Helena Lúcia Alves Pereira, Sandra Lúcia Euzébio Ribeiro
No abstract text is available yet for this article.
March 2018: European Journal of Rheumatology
Pandiarajan Vignesh, Surjit Singh
No abstract text is available yet for this article.
March 2018: European Journal of Rheumatology
Dèlia Reina, Hèctor Corominas
No abstract text is available yet for this article.
March 2018: European Journal of Rheumatology
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