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European Journal of Rheumatology

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https://www.readbyqxmd.com/read/30451655/a-single-arm-open-label-study-to-assess-the-immunogenicity-safety-and-efficacy-of-etanercept-manufactured-using-the-serum-free-high-capacity-manufacturing-process-administered-to-patients-with-rheumatoid-arthritis
#1
Pavol Polák, Porin Peric, Ingrid Louw, Stefanie M Gaylord, Theresa Williams, Jean-Claude Becker, Ron Pedersen, Joan Korth-Bradley, Bonnie Vlahos
OBJECTIVE: To evaluate the immunogenicity, safety, and efficacy of etanercept (ETN) manufactured using the serum-free, high-capacity manufacturing (SFHCM) process in patients with rheumatoid arthritis (RA). METHODS: In this global, multicenter, open-label, single-arm study (NCT02378506), 187 adult patients with moderate to severe RA received ETN 50 mg once weekly for 24 weeks manufactured using the SFHCM process. Immunogenicity (presence of antidrug antibodies (ADAs) and neutralizing antibodies (NAbs)) was assessed at 12 and 24 weeks...
November 16, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30451654/imaging-in-rheumatoid-arthritis-psoriatic-arthritis-axial-spondyloarthritis-and-osteoarthritis-an-international-viewpoint-on-the-current-knowledge-and-future-research-priorities
#2
REVIEW
Xenofon Baraliakos, Philip G Conaghan, Maria-Antonietta D'agostino, Walter Maksymowych, Esperanza Naredo, Mikkel Ostergaard, Georg Schett, Paul Emery
Imaging is increasingly used in the routine management of rheumatic diseases as well as in the clinical trials of these disorders. This viewpoint, authored by a group of international imaging experts following two meetings dedicated to imaging in rheumatology, reports a consensus about the current knowledge and addresses where further research should be focused based on the views of the international imaging experts and discussion of the evidence with attending imaging practitioners. The goal was to maximize the potential of imaging to improve the clinical management of four rheumatic diseases...
November 16, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30451653/musculoskeletal-manifestations-of-alkaptonuria-a-case-report-and-literature-review
#3
REVIEW
Katherine Wu, Erin Bauer, Gihyun Myung, Meika A Fang
Alkaptonuria (AKU) is a rare autosomal recessive disorder that results from the deficient activity of homogentisate 1,2-dioxygenase and leads to increased levels of homogentisic acid (HGA) and its oxidized product benzoquinone acetic acid (BQA). Both HGA and BQA form polymerized deposits that lead to a bluish-black discoloration of the cartilage as well as degeneration, inflammation, and calcification of the tendons, ligaments, intervertebral discs, and large joints and increased bone resorption. A brittle and fragmented cartilage forms and leads to aberrant loading of the subchondral bone...
November 16, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30407167/sporadic-late-onset-nemaline-myopathy-slonm-in-an-adult-presenting-with-progressive-muscle-weakness
#4
Shereen Paramalingam, Jason M Dyke, Johannes C Nossent
Sporadic late onset nemaline myopathy (SLONM) is a rare, intractable acquired myopathy that is characterised by progressive muscle weakness and the presence of nemaline rods in myofibres. Unlike the congenital form of nemaline myopathy (NM), there are only few case reports and series on SLONM in the scientific literature. We present a case report of SLONM in a 62-year-old male from a rural town in Western Australia, without any of the conditions often associated with SLONM such as monoclonal gammopathy of uncertain significance or HIV infection...
November 6, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30407166/novel-presentations-of-periodic-fever-syndromes-discrepancies-between-genetic-and-clinical-diagnoses
#5
Tiffany K Hoang, Daniel A Albert
OBJECTIVE: The Periodic fever syndromes (PFS) are a group of disorders of the innate immune system. We investigated patients diagnosed with PFS at the Dartmouth Hitchcock Pediatric Rheumatology Clinic. METHODS: Case acquisition was performed by reviewing ICD 9/10 coded records for familial Mediterranean fever (ICD 9 277.31), laboratory test records for PFS genetic screening, and clinic records between 1/1/2011 and 12/31/2017. RESULTS: Twenty-seven cases had clinical evaluations including PFS genetic screening...
November 6, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30407165/tuberculin-test-conversion-in-patients-with-chronic-inflammatory-arthritis-receiving-biological-therapy
#6
Osvaldo Luis Cerda, María De Los Angeles Correa, Amelia Granel, Ana Ines Marcos, Claudia Giraldo, Oscar Rillo, Emilce Edith Schneeberger, Gustavo Citera
OBJECTIVE: The blockade of inflammatory mediators produced by biological therapies is associated with an increased risk of opportunistic infections, as for example Mycobacterium tuberculosis (MT). Given the endemic situation of tuberculosis (TB) in some countries and immunosuppression/anergy of patients with chronic inflammatory arthritis, we wonder whether it is necessary to monitor the MT infection after starting the biological treatment. To evaluate the frequency of the tuberculin skin test (TST) conversion and its association with an active TB infection and other disease variables...
November 6, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30407164/positive-anti-mog-antibodies-in-a-patient-with-sj%C3%A3-gren-s-syndrome-and-transverse-myelitis
#7
Kerry Jobling, David Ledingham, Wan-Fai Ng, Joe Guadagno
Twenty percent of patients with Sjögren's syndrome experience associated neurological disease. Transverse myelitis (TM) frequently forms part of a neuromyelitis optica spectrum disorder associated with the presence of anti-aquaporin 4 (AQP4) antibodies. We report the first described case of a patient who developed TM and the presence of a newly recognized antibody, anti-myelin oligodendrocyte protein (MOG), who went on to develop Sjögren's syndrome. AQP4 and MOG antibodies should be tested to guide prognostically the chances of further relapse as well as the type and duration of immunotherapy in patients with coexisting Sjögren's syndrome and TM...
November 6, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30388077/multiple-pulmonary-nodules-in-rheumatoid-arthritis
#8
LETTER
Gökhan Sargın, Taşkın Şentürk
No abstract text is available yet for this article.
October 31, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30388076/carbamazepine-induced-systemic-lupus-erythematosus-a-case-based-review
#9
REVIEW
Bonifacio Álvarez-Lario, Mónica Bártulos-Iglesias, María Colazo-Burlato, Jesús Macarrón-Vicente
A case of carbamazepine-induced systemic lupus erythematosus (CBZ-DILE) is presented, along with a literature review, with the aim to define the clinical and serological characteristics of this group, and compare them with systemic lupus erythematosus (SLE) triggered by other drugs (DILE). A 31-year-old woman presented with a 6-month history of hand arthritis and nasal ulcers. She had been diagnosed with epilepsy at 12 years of age and had continued treatment with carbamazepine (CBZ) for the past 18 years with excellent clinical control...
October 31, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30388075/paraneoplastic-polyarthritis-as-the-first-manifestation-of-lingual-carcinoma
#10
Andrea Briones-Figueroa, Walter Alberto Sifuentes-Giraldo, Rosario Carrillo-Gijón, José Luis Morell-Hita
Paraneoplastic polyarthritis is an inflammatory arthritis, is usually seronegative, and has a temporal and pathophysiological relationship with an underlying malignancy. Although head and neck tumors may be a cause of paraneoplastic polyarthritis, its association with tongue carcinoma has not been previously reported. We present the case of a 69-year-old man who was a former smoker and presented with polyarthritis since 2 months in the wrists, proximal interphalangeal joints, knees, and elbows, with increased levels of acute-phase reactants; negativity for rheumatoid factor, anticitrullinated cyclic peptide antibody, and antinuclear antibody; and negative results for crystals and microorganisms in the synovial fluid...
October 31, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30388072/swollen-digits-due-to-pachydermodactyly-resembling-inflammatory-arthritis
#11
Ayda Acar, Fatmagül Dirican, Banu Yaman, İpek Tamsel, Gökhan Keser, Işıl Karaarslan
Pachydermodactyly is a rare digital fibromatosis, characterized by painless, fusiform swelling in proximal interphalangeal joints. Since it may be misdiagnosed as inflammatory arthritis, it is important to call physicians' attention to this rarely seen condition to avoid unnecessary immunosuppressive treatment. Hereby, we present a case of a pachydermodactyly that had been previously followed-up and treated as an inflammatory arthritis for 4 years. We describe the clinical, radiological, and dermoscopic features of the case...
October 31, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30489254/exon-2-is-it-the-good-police-in-familial-mediterranean-fever
#12
Şule Yaşar Bilge, Dilek Solmaz, Soner Şenel, Hakan Emmungil, Levent Kılıç, Sibel Yılmaz Öner, Fatih Yıldız, Sedat Yılmaz, Duygu Ersözlü Bozkırlı, Müge Aydın Tufan, Sema Yılmaz, Veli Yazısız, Yavuz Pehlivan, Cemal Beş, Gözde Yıldırım Çetin, Şükran Erten, Emel Gönüllü, Fezan Şahin, Servet Akar, Kenan Aksu, Umut Kalyoncu, Haner Direskeneli, Eren Erken, Bünyamın Kısacık, Mehmet Sayarlıoğlu, Muhammed Çınar, Timuçin Kaşifoğlu, İsmail Sarı
OBJECTIVE: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Most of the identified disease-causing mutations are located on exon 10. As the number of studies about the effect of the exonal location of the mutation and its phenotypic expression is limited, we aimed to investigate whether the exonic location of the Mediterranean fever (MEFV) mutation has an effect on the clinical manifestation in patients with FMF. METHODS: Study population was derived from the main FMF registry that included 2246 patients from 15 different rheumatology clinics...
October 12, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30489252/musculoskeletal-manifestations-in-pediatric-patients-infected-with-human-immunodeficiency-virus-developing-country-perspective
#13
Debrup Chakladar, Rakesh K Mondal, Tapas Kumar Sabui, Souravi Bhowmik, Tamoghna Biswas
OBJECTIVE: Musculoskeletal manifestations in children infected with human immunodeficiency virus (HIV) are responsible for increased morbidity and decreased quality of life. Even in this era of highly active anti-retroviral therapy (HAART), there are limited studies on different rheumatological manifestations in pediatric patients with HIV, and the spectrum of musculoskeletal manifestation in pediatric HIV is yet to be established. METHODS: A single-center, prospective, observational study was carried out from October 2014 to September 2016 in a tertiary care hospital of Eastern India with 517 children infected with HIV aged between 3 and 19 years...
October 12, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30308144/acro-osteolysis
#14
Joe Thomas, Jewel Jose
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30308143/unilateral-shortening-of-third-metacarpal-bone-in-a-patient-with-tuberous-sclerosis
#15
Ahad Azami, Afshin Habibzadeh
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30308142/disseminated-hollow-and-solid-lung-nodules-as-a-unique-pulmonary-manifestation-of-rheumatoid-arthritis
#16
Wolfgang Jungraithmayr, Njanja Enz, Frank Lippek
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30308140/transient-osteoporosis-of-the-hip
#17
Joe Thomas, Kurian Ninan
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30308138/chronic-large-nasal-bloody-crusting-and-recurrent-episcleritis-limited-granulomatosis-with-polyangiitis
#18
Nurşen Düzgün, Haldun Umudum
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30501851/frequency-of-pulmonary-hypertension-in-transthoracic-echocardiography-screening-is-not-increased-in-takayasu-arteritis-experience-from-a-single-center-in-turkey
#19
Melike Kalfa, Hakan Emmungil, Oktay Musayev, Özgül Soysal Gündüz, Zevcet Yılmaz, Vedat İnal, Servet Akar, Nurullah Akkoç, Fatoş Önen, Meral Kayıkçıoğlu, Gökhan Keser, Kenan Aksu
OBJECTIVE: Pulmonary hypertension (PH) may occur in Takayasu arteritis (TA), mostly due to pulmonary arteritis, but also due to left heart disease and/or chronic thromboembolism (CTE). Using transthoracic echocardiography (TTE), we investigated the frequency of PH caused by pulmonary arteritis. METHODS: This cross-sectional study included 70 patients with TA fulfilling the 1990 ACR criteria, 68 healthy controls, and 67 patients with systemic sclerosis (SSc) fulfilling the 1980 ACR criteria representing the disease control group...
December 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/30501850/the-assessment-of-contributing-factors-to-oral-ulcer-presence-in-beh%C3%A3-et-s-disease-dietary-and-non-dietary-factors
#20
Merve İris, Ezgi Özçıkmak, Aysun Aksoy, Fatma Alibaz-Öner, Nevsun İnanç, Tülin Ergun, Haner Direskeneli, Gonca Mumcu
OBJECTIVE: The aim of this study was to assess the contributing factors for oral ulcer activity in Behçet's disease (BD). METHODS: Ninety-two patients with BD (F/M: 42/50, mean age: 38.7±10.02 years) participated in this cross-sectional study. Data regarding disease-related factors, smoking patterns, and self-reported dietary/non-dietary triggering factors for oral ulcer activity were collected by a questionnaire. Treatment protocol was categorized as mild and intensive groups associated with organ involvements...
December 2018: European Journal of Rheumatology
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