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European Journal of Rheumatology

Farahnaz Noroozinia, Leila Mahmoudzadeh, Farzaneh Hosseini Gharalari, Khadijeh Makhdoomi, Ata Abbasi
OBJECTIVE: Lupus nephritis is one of the most serious and common complications of systemic lupus erythematosus. It has an unpredictable course, and the type, severity, and activity of renal lesions cannot be assessed only by clinical and laboratory findings. The aim of the present study was to determine the relationship between the expression of CD34 and the histopathological findings of lupus nephritis. METHODS: A total of 73 renal biopsy samples of patients with a diagnosis of lupus nephritis were examined for CD34 expression by immunohistochemistry...
October 10, 2018: European Journal of Rheumatology
Mine Hayriye Sorgun, Mustafa Aykut Kural, Canan Yücesan
OBJECTIVE: Neuro-Behçet's disease (NBD) is a rare manifestation of Behçet's disease (BD) and may cause severe disability. The aim of this study was to evaluate the treatment response in patients with NBD and to investigate the parameters that may influence the prognosis of the disease in patients with severe to mild-moderate disability. METHODS: The files of 60 patients admitted to our outpatient clinic for NBD between January 2007 and June 2014 were retrospectively reviewed...
October 10, 2018: European Journal of Rheumatology
Ileana Vázquez-Otero, Yerania Rodríguez-Navedo, Karina Vilá-Rivera, Mariely Nieves-Plaza, Jessica Morales-Ortiz, A Valance Washington, Luis M Vilá
OBJECTIVE: The soluble triggering receptor expressed on myeloid cells (TREM-1)-like transcript 1 (sTLT1) has a modulatory effect on the activation of TREM-1. We compared plasma sTLT-1 levels between patients with systemic lupus erythematosus (SLE) and healthy individuals and determined the association between sTLT-1 levels and clinical features and patient-reported outcomes (PROs) among patients with lupus. METHODS: An unmatched case-control study was conducted in 46 patients with SLE and 28 healthy subjects...
October 10, 2018: European Journal of Rheumatology
Joe Thomas, Jewel Jose
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
Ahad Azami, Afshin Habibzadeh
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
Wolfgang Jungraithmayr, Njanja Enz, Frank Lippek
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
Joe Thomas, Kurian Ninan
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
Nurşen Düzgün, Haldun Umudum
No abstract text is available yet for this article.
October 8, 2018: European Journal of Rheumatology
Abhishek Zanwar, Latika Gupta, Ramnath Misra
No abstract text is available yet for this article.
August 2, 2018: European Journal of Rheumatology
Binoy Paul, Rosh Pariyapurath
OBJECTIVE: Rheumatoid arthritis (RA) is a multifactorial disease; it leads to disabling and painful chronic inflammatory arthritis. Its onset may be delayed or even prevented by modifying the risk factors involved. Many genetic, epigenetic, and environmental factors are implicated in the pathogenesis of RA. The objectives of this case-control study were to assess various risk factors in our population and to compare the same with age- and sex-matched controls. METHODS: We studied 118 cases with RA diagnosed using the EULAR criteria...
September 2018: European Journal of Rheumatology
Richard Oluyinka Akintayo, Olufemi Opeyemi Aworinde, Osaze Ojo, Foluke Comfort Akintayo, Olawale Matthias Akinlade, Rasheed Olaide Awodun, Sakiru Oyetunji Isa
OBJECTIVE: Contrary to the old belief that rheumatoid arthritis (RA) is rare in sub-Saharan Africa, recent reports have increasingly recognized that the burden of the disease has probably been long under-appreciated in West Africa. Thus, fertility and other attributes of the reproductive lives among women with RA have not received research attention in Africa. We aimed to compare the fertility between married Nigerian women with and without RA. METHODS: A comparative study of 50 women with RA and 50 women without RA was conducted via the specialist rheumatology clinics at two teaching hospitals in Nigeria...
September 2018: European Journal of Rheumatology
Vandana Pradhan, Pallavi Pandit, Prathamesh Surve, Maxime Lecerf, Anjali Rajadhyaksha, Milind Nadkar, Prasad V Khadilkar, Durga A Chougule, Aalaap A Naigaonkar, Sébastien Lacroix-Desmazes, Jagadeesh Bayry, Kanjaksha Ghosh, Srini V Kaveri
OBJECTIVE: Antibodies with catalytic (hydrolytic) properties to DNA or RNA have been reported in systemic lupus erythematosus (SLE). However, it is well known that ethnicity plays an important role in the presentation of SLE and severity of the disease; hence, these data may not truly represent a general feature of all SLE patients. Therefore, we have analyzed the hydrolyzing activity of immunoglobulin G (IgG) of SLE patients from the Indian population with an aim to decode whether the catalytic antibody response represents part of an active disease process...
September 2018: European Journal of Rheumatology
Kerry Jobling, Hanaa Rajabally, Wan-Fai Ng
There are emerging case reports worldwide of complete heart block in adults who test positive for anti-Ro antibodies and the underlying primary Sjögren's syndrome (pSS). The association between fetal/congenital cardiac abnormalities and transplacental transfer of anti-Ro antibodies is well established; there is, however, an ongoing debate about the underlying mechanism of activity of these antibodies in the cardiac tissue. In the past, maternal cardiac tissue was believed to be resistant to these pathogenic effects...
September 2018: European Journal of Rheumatology
Fernando Sommerfleck, Emilce Schneeberger, Gustavo Citera
OBJECTIVE: The objective of this study was to compare the frequency of comorbidities among patients with ax-SpA in the general population and to evaluate the impact of these comorbidities on the functional status and quality of life. METHODS: Patients with ax-SpA fulfilling the modified New York 1984 criteria for Ankylosing Spondylitis (AS) and/or Assessment of SpondyloArthritis International Society (ASAS) 2009 criteria for patients with ax-SpA belonging to the ESPAXIA cohort ("Estudio de eSPondiloartritis Axial Irep Argentina") were included...
September 2018: European Journal of Rheumatology
Francisco Javier Domínguez Díez
Treatment with anti-tumor necrosis factor alpha (anti-TNF α) drugs may lead to demyelinating polyneuropathies. Here, we present the case of a patient with rheumatic disease who developed sensory polyneuropathy probably related to anti-TNF α drugs. The patient was diagnosed with undifferentiated arthritis during treatment with weekly injection of golimumab. She presented a progressive picture of paresthesia of all four limbs, with distal and symmetrical predominance, associated with mild dysarthria and universal areflexia, except for the Achilles reflex...
September 2018: European Journal of Rheumatology
Emre Tekgöz, Egemen Akıncıoğlu, Muhammet Çınar, Sedat Yılmaz
Exogenous ochronosis is characterized by hyperpigmented skin lesions that arise in association with local suppression of homogentisic acid oxidase enzyme. Although it generally develops in association with topical application of chemical agents, it can occasionally develop in association with antimalarial drugs. Here we present the case of a patient with rheumatoid arthritis who developed hyperpigmentation on the face and neck regions during hydroxychloroquine treatment. Hydroxychloroquine is being widely used in rheumatology practice, and cutaneous hyperpigmentation may develop as an adverse effect...
September 2018: European Journal of Rheumatology
Didem Saygın, Abrahim U Syed, Careen Y Lowder, Sunil Srivastava, Juan J Maya, Rula A Hajj-Ali
OBJECTIVE: Hidradenitis suppurativa (HS) is an inflammatory skin condition that can cause profound morbidity. Patients can present with recurrent nodules, sinus tract formation, abscesses, and/or scarring, mainly affecting the intertriginous areas. Case reports have documented the coexistence of HS and inflammatory eye disease (IED). Herein, we aimed to assess the types of IED associated with HS and the outcomes of IED treatment in patients with HS. METHODS: All the cases with a diagnosis of HS and any IED were identified...
September 2018: European Journal of Rheumatology
Andrew B Lemmey, Thomas J Wilkinson, Celine M Perkins, Luke A Nixon, Fazal Sheikh, Jeremy G Jones, Yasmeen A Ahmad, Thomas D O'brien
OBJECTIVE: Adverse changes in body composition, specifically decreased muscle mass (MM) and increased fat mass, characterize rheumatoid arthritis (RA). These changes, termed rheumatoid cachexia (RC), are important contributors to the disability and elevated co-morbidity risk of RA. Recently, we observed substantial muscle loss (~2 kg) in a patient with RA following a single intramuscular (IM) corticosteroid (CS) injection to treat a disease flare. The aim of the current study is to determine whether this apparent iatrogenic effect of IM CS is typical, i...
September 2018: European Journal of Rheumatology
Tarek Carlos Salman-Monte, Irene Carrión-Barberà, Carolina Pérez García, Javier Gimeno Beltrán, Jordi Monfort
Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide clinical expression, and musculoskeletal manifestations are the most frequent manifestations of the disease. Digestive manifestations, however, are less prevalent, appearing in only 2%-30% of the patients. Among these cases, the association of SLE with autoimmune hepatitis (AIH) is considered to be rare, with only a few cases documented in the medical literature. We present the only reported case to date of a patient diagnosed with SLE suffering from a flare with a simultaneous hepatic and muscular inflammatory involvement, both evidenced by biopsy...
September 2018: European Journal of Rheumatology
Nicholas G Kounis, Ioanna Koniari, Dimitrios Velissaris, George Soufras, George Hahalis
No abstract text is available yet for this article.
September 2018: European Journal of Rheumatology
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