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EJIFCC

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https://www.readbyqxmd.com/read/29333152/erratum-1-pediatric-obesity-and-cardiometabolic-disorders-risk-factors-and-biomarkers
#1
E Levy, A K Saenger, M W Steffes, E Delvin
[This corrects the article on p. 6 in vol. 28, PMID: 28439216.].
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333151/lab-test-findings-in-the-elderly
#2
Barna Vásárhelyi, Lóránd A Debreczeni
No abstract text is available yet for this article.
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333150/evaluation-of-the-correlation-coefficient-of-polyethylene-glycol-treated-and-direct-prolactin-results-and-comparability-with-different-assay-system-results
#3
Shyamali Pal
The presence of Macro prolactin is a significant cause of elevated prolactin resulting in misdiagnosis in all automated systems. Poly ethylene glycol (PEG) pretreatment is the preventive process but such process includes the probability of loss of a fraction of bioactive prolactin. Surprisingly, PEG treated EQAS & IQAS samples in Cobas e 411 are found out to be correlating with direct results of at least 3 immunoassay systems and treated and untreated Cobas e 411 results are comparable by a correlation coefficient...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333149/a-summary-of-worldwide-national-activities-in-chronic-kidney-disease-ckd-testing
#4
Roberto Ruiz-Arenas, Rosa Sierra-Amor, David Seccombe, Stella Raymondo, Maria Stella Graziani, Mauro Panteghini, Tewogbade A Adedeji, Shanthi Naidu Kamatham, Vanja Radišić Biljak
Chronic kidney disease (CKD) is a major public health issue worldwide and is associated with adverse health outcomes, especially in low- and middle-income countries. In a cash limited healthcare system, guidelines that improve the efficiency of health care free up resources needed for other healthcare services. This short review presents some examples from national acitivities in CKD testing, including countries throughout the globe: Mexico in North America, Uruguay in South America, Italy in Europe, Nigeria in Africa and India in Asia...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333148/a-pathway-to-national-guidelines-for-laboratory-diagnostics-of-chronic-kidney-disease-examples-from-diverse-european-countries
#5
Vanja Radišić Biljak, Kristin Moberg Aakre, Dogan Yucel, Anne-Sophie Bargnoux, Jean-Paul Cristol, Laurence Piéroni
The principal benefit of guidelines is to improve the quality of care received by patients. In the 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (KDIGO) was released and it is designed to provide information and assist decision making. This review gives a brief overview of a various national CKD guidelines that rely on the newly released KDIGO guidelines. All of the included countries (France, Turkey, Norway and Croatia) are non-English speaking countries and they differ in population and socio economic aspects...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333147/novel-filtration-markers-for-gfr-estimation
#6
Amy B Karger, Lesley A Inker, Josef Coresh, Andrew S Levey, John H Eckfeldt
Creatinine-based glomerular filtration rate estimation (eGFRcr) has been improved and refined since the 1970s through both the Modification of Diet in Renal Disease (MDRD) Study equation in 1999 and the CKD Epidemiology Collaboration (CKD-EPI) equation in 2009, with current clinical practice dependent primarily on eGFR for accurate assessment of GFR. However, researchers and clinicians have recognized limitations of relying on creatinine as the only filtration marker, which can lead to inaccurate GFR estimates in certain populations due to the influence of non-GFR determinants of serum or plasma creatinine...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333146/cystatin-c-is-indispensable-for-evaluation-of-kidney-disease
#7
Anders Grubb
The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin C- and creatinine-based equations, that cystatin C-based GFR-estimating equations are superior to creatinine-based equations in predicting end-stage renal disease, cardiovascular manifestations, hospitalisation and death, and, finally that cystatin C is required to diagnose the new syndrome "Shrunken Pore Syndrome" with its high mortality and morbidity, even in the absence of reduced GFR...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333145/moving-toward-standardization-of-urine-albumin-measurements
#8
Jesse C Seegmiller, W Greg Miller, Lorin M Bachmann
Measurement of urine albumin is important for detecting and monitoring kidney disease. At the present time, measurement of urine albumin is not standardized due to the lack of a reference system, which includes both a reference measurement procedure and certified reference materials. Developing a reference system will provide a means for clinical laboratory measurement procedures to become standardized and will enable successful use of uniform clinical decision points. Currently, urine albumin results vary in excess of 40% depending on which commercially available measurement procedure is utilized for measurement...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333144/did-creatinine-standardization-give-benefits-to-the-evaluation-of-glomerular-filtration-rate
#9
Laurence Piéroni, Anne-Sophie Bargnoux, Jean-Paul Cristol, Etienne Cavalier, Pierre Delanaye
During the last decade, a lot of efforts has been made to improve the evaluation of renal functions. Measured Glomerular Filtration Rate (GFR) remains the only valuable test to confirm or confute the status of chronic kidney disease (CKD) and is recommended by Kidney Disease Global Outcomes guidelines when estimation of GFR is not reliable. However, in routine clinical practice, serum creatinine remains the one of the most prescribed biological parameters and is an undeniable factor, alone or in association with other parameters, of the estimation of GFR...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333143/task-force-on-ckd-we-have-come-a-long-way
#10
Graham R D Jones
Chronic Kidney Disease (CKD) is an important medical condition where diagnosis, staging and monitoring is largely based on routine laboratory tests. During the last 15 years there have been many important changes in the clinical management of CKD described in key international guidelines. In order to successfully implement these guidelines, laboratories must collaborate with clinicians to provide a co-ordinated service, including accurate measurements and of creatinine and urine albumin and reporting of an estimated glomerular filtration rate (eGFR)...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333142/ifcc-task-force-on-chronic-kidney-disease-integrated-project-tf-ckd-special-issue
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333141/foreword-of-the-editor
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333140/farewell-message-from-the-editor-in-chief
#13
(no author information available yet)
No abstract text is available yet for this article.
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29075173/case-report-biliary-pancreatitis-with-acute-cholangitis-in-a-patient-under-anticoagulant-treatment-with-dabigatran
#14
Franziska Baumann-Durchschein, Thomas Gary, R B Raggam
We report a case of acute onset of a biliary pancreatitis with cholangitis presented in our emergency department. The patient was under anticoagulant therapy with dabigatran due to persistent atrial fibrillation. Pancreatic enzymes including lipase were elevated above the linear measuring range and bilirubin together with cholestasis enzymes was also highly elevated. An ERCP with papillotomy was urgently indicated because postponing could lead to further deterioration of the patient's condition. Coagulation testing showed a prolonged thrombin time above 160sec which was followed by a diluted thrombin time (Haemoclot Test) resulted in a peak-level of dabigatran thus confirming full anticoagulation...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29075172/retrospective-approach-to-evaluate-interferences-in-immunoassay
#15
Jayesh Warade
BACKGROUND: Despite the increase in sensitivity and specificity of immunoassay technique over years, analytical interference remains to be major area of concern. The interfering substances are endogenous substances that are natural, polyreactive antibodies as heterophilic or auto antibodies, or human anti-animal antibodies together with other unsuspected binding proteins that are unique to the individual. Interfering substances can interfere with the reaction between analyte and reagent antibodies in immunoassay resulting in false positive or negative values...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29075171/factors-affecting-quality-of-laboratory-services-in-public-and-private-health-facilities-in-addis-ababa-ethiopia
#16
Eyob Abera Mesfin, Binyam Taye, Getachew Belay, Aytenew Ashenafi, Veronica Girma
BACKGROUND: Quality laboratory service is an essential component of health care system but in Sub-Saharan Africa such as Ethiopia, laboratories quality system remains weak due to several factors and it needs more attention to strengthen its capacity and quality system. METHODOLOGY: A cross sectional study was conducted using a questionnaire to assess factors affecting the quality of laboratory service at private and public health institutions in Addis Ababa. RESULTS: A total of 213 laboratory professionals participated in the study and 131 (61...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29075170/correlation-of-hba1c-levels-with-body-mass-index-in-newly-diagnosed-polycystic-ovary-syndrome
#17
Manju Bala, Meenakshi, Menaka K, Anjali Gupta
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a heterogeneous, multisystem endocrinopathy in women of reproductive age manifested with various metabolic disturbances and a wide spectrum of clinical features such as obesity, menstrual abnormalities and hyperandrogenism. Hyperinsulinemia was noted in 50% to 70% of PCOS patients and plays a central role in the development of further complications. The prevalence of obesity in PCOS ranges from 38% to 87%. It has been reported in previous studies that the prevalence of insulin resistance (IR) is higher in obese PCOS women than obesity without PCOS...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29075169/e-learning-a-model-to-support-ongoing-education
#18
Ronda F Greaves
No abstract text is available yet for this article.
October 2017: EJIFCC
https://www.readbyqxmd.com/read/29075168/postprandial-dyslipidemia-pathophysiology-and-cardiovascular-disease-risk-assessment
#19
Victoria Higgins, Khosrow Adeli
Although the fed state predominates over the course of a day, the fasting lipid profile has traditionally been used to assess cardiovascular disease (CVD) risk. The nonfasting lipid profile may be more reflective of the daily circulating plasma lipids and simplifies lipid monitoring for patients, laboratories, and clinicians. Nonfasting triglyceride levels are also independently associated with cardiovascular events, leading to several clinical guidelines (e.g. in Denmark, the UK, Europe, and Canada) now recommending nonfasting lipid testing in the primary prevention setting...
October 2017: EJIFCC
https://www.readbyqxmd.com/read/28860961/case-report-a-toddler-with-anasarca-caused-by-congenital-nephrotic-syndrome
#20
Tumelo M Satekge, Olivia Kiabilua, Gertruida van Biljon, Komala Pillay, Tahir S Pillay
Congenital nephrotic syndrome is a rare inherited disorder arising from defects in the proteins of the cells in the glomerular basement membrane and develops either in utero or at birth. The clinical presentation is the result of massive protein loss in the urine with associated compensatory mechanisms. Here we present a clinical case of a female toddler with a history of anasarca (severe generalised edema) from birth and who presents with the classical biochemical laboratory findings of nephrotic syndrome, together with the more pronounced features that arise from protein loss including abnormal thyroid function testing and a marked hypercholesterolaemia...
May 2017: EJIFCC
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