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https://www.readbyqxmd.com/read/27683538/emerging-and-disruptive-technologies
#1
Larry J Kricka
Several emerging or disruptive technologies can be identified that might, at some point in the future, displace established laboratory medicine technologies and practices. These include increased automation in the form of robots, 3-D printing, technology convergence (e.g., plug-in glucose meters for smart phones), new point-of-care technologies (e.g., contact lenses with sensors, digital and wireless enabled pregnancy tests) and testing locations (e.g., Retail Health Clinics, new at-home testing formats), new types of specimens (e...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683537/st2-and-galectin-3-ready-for-prime-time
#2
Wouter C Meijers, A Rogier van der Velde, Rudolf A de Boer
ST2 and galectin-3 are emerging biomarkers in the field of heart failure and have been extensively studied, and that whether they provide additional prognostic value on top of the clinical models and the gold standard in HF, (NT-pro)BNP. Our aim was to provide a comprehensive review of these emerging HF-related biomarkers in chronic, acute and incident heart failure. Regardless of the type of heart failure, both biomarkers seem to have an additional effect on top of the clinical model including natriuretic peptides...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683536/soluble-st2-and-galectin-3-what-we-know-and-don-t-know-analytically
#3
Thomas Mueller, Benjamin Dieplinger
The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of both analytes...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683535/high-sensitivity-cardiac-troponin-assays-how-to-implement-them-successfully
#4
Frederick K Korley, Allan S Jaffe
High sensitivity troponin (hsTn) assays provide an unprecedented opportunity to improve the detection and treatment of cardiac injury from coronary and non-coronary causes. They may also play a role in guiding the primary and secondary prevention of cardiovascular disease. However, to derive maximal benefit from their use, careful planning for the implementation of these new assays is required. In this manuscript, we will discuss actions that can be taken during hsTn pre-implementation, implementation and post-implementation phases...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683534/can-natriuretic-peptides-be-used-to-guide-therapy
#5
Antoni Bayes-Genis, Josep Lupón, Allan S Jaffe
Over the last 15 years, the hypothesis that intensified treatment directed at reducing natriuretic peptide (NP) concentrations may improve the outcomes of patients with heart failure (HF) has been scrutinized in several prospective clinical trials, with conflicting results. Collectively, however, the data suggest that NP concentrations may be useful in guiding HF management and improving HF-related morbidity and mortality. In this review, we summarize the existing data investigating the use of NPs as targets for outpatient HF therapy...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683533/analytical-issues-with-natriuretic-peptides-has-this-been-overly-simplified
#6
Alexander G Semenov, Alexey G Katrukha
Natriuretic peptides (NPs) were first described as cardiac biomarkers more than two decades ago. Since that time, numerous studies have confirmed NPs' diagnostic and prognostic utilities as biomarkers of myocardial function. However, we must now admit that despite the NPs' relatively long period of use in clinical practice, our understanding of the biochemistry and the variety of circulating forms of NPs, as well as of their potential as biomarkers, remains far from being complete and comprehensive. The highly complex nature and wide diversity of circulating forms of NPs make their accurate measurements in plasma far more complex than initially believed...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683532/the-world-is-changing-are-we-ready
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683531/foreword-of-the-editor
#8
(no author information available yet)
No abstract text is available yet for this article.
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683529/adding-value-in-the-postanalytical-phase
#9
Éva Ajzner
Apart from maintaining the highest quality of analytical test results, laboratories are now getting more focused on how to achieve the greatest impact of laboratory results on their patient's outcome. Laboratory professionals are now in the learning phase of implementing new practices at different steps of the extra-analytical phases of the testing process where laboratories used to contribute seldom, only sporadically. Recently, the achievable levels of harmonization and responsible contributors at various steps of the testing process have also been proposed...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683528/clinical-laboratories-production-factories-or-specialized-diagnostic-centers
#10
János Kappelmayer, Judit Tóth
Since a large proportion of medical decisions are based on laboratory results, clinical laboratories should meet the increasing demand of clinicians and their patients. Huge central laboratories may process over 10 million tests annually; they act as production factories, measuring emergency and routine tests with sufficient speed and accuracy. At the same time, they also serve as specialized diagnostic centers where well-trained experts analyze and interpret special test results. It is essential to improve and constantly monitor this complex laboratory service, by several methods...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683527/interpretation-of-blood-microbiology-results-function-of-the-clinical-microbiologist
#11
Katalin Kristóf, Júlia Pongrácz
The proper use and interpretation of blood microbiology results may be one of the most challenging and one of the most important functions of clinical microbiology laboratories. Effective implementation of this function requires careful consideration of specimen collection and processing, pathogen detection techniques, and prompt and precise reporting of identification and susceptibility results. The responsibility of the treating physician is proper formulation of the analytical request and to provide the laboratory with complete and precise patient information, which are inevitable prerequisites of a proper testing and interpretation...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683526/deficiencies-of-the-natural-anticoagulants-novel-clinical-laboratory-aspects-of-thrombophilia-testing
#12
Zsuzsanna Bereczky, Réka Gindele, Marianna Speker, Judit Kállai
Venous thrombosis is a typical common complex disease as acquired and genetic causes play a role in its development. The different "loss of function" mutations of the natural anticoagulant system lead to antithrombin (AT), protein C (PC) and protein S (PS) deficiencies. Since thrombophilia testing has high cost and it has several methodological issues (analytical, pre-analytical), which makes the interpretation of results difficult, considerations should be made on the indications of testing, on the parameters that are measured and on the best available method to use...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683525/the-clinical-value-of-soluble-urokinase-plasminogen-activator-receptor-supar-levels-in-autoimmune-connective-tissue-disorders
#13
Barna Vasarhelyi, Gergely Toldi, Attila Balog
The assessment of the general inflammatory condition of patients with autoimmune connective tissue disorders (ACTD) is a major challenge. The use of traditional inflammatory markers including CRP-levels and erythrocyte sedimentation rate (ESR) is limited by several preanalytical factors and their low specificities. Soluble urokinase plasminogen activator receptor (suPAR) is one of the novel candidate markers that is increasingly used in immune mediated disorders. In our studies we compared suPAR levels of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and ankylosing spondylitis with those of healthy controls...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683524/non-invasive-assessment-of-viability-in-human-embryos-fertilized-in-vitro
#14
Gábor L Kovács, Gergely Montskó, Zita Zrínyi, Nelli Farkas, Ákos Várnagy, József Bódis
Human reproduction is a relatively inefficient process and therefore the number of infertile couples is high. Assisted reproductive technologies (ART) have facilitated the birth of over five million children worldwide. ART, however, superimposes its own relative inefficiency on the preexisting inefficiency of normal reproduction. The efficiency (expressed as pregnancy rate) is generally not more than 30%. Modern reproductive medicine is gradually moving from multiple embryo transfer to the transfer of a single embryo, mainly because of obvious and unwanted side effects of multiple embryo transfer (e...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683523/biochemical-markers-of-myocardial-damage
#15
Geza S Bodor
Heart diseases, especially coronary artery diseases (CAD), are the leading causes of morbidity and mortality in developed countries. Effective therapy is available to ensure patient survival and to prevent long term sequelae after an acute ischemic event caused by CAD, but appropriate therapy requires rapid and accurate diagnosis. Research into the pathology of CAD have demonstrated the usefulness of measuring concentrations of chemicals released from the injured cardiac muscle can aid the diagnosis of diseases caused by myocardial ischemia...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683522/the-hungarian-society-of-laboratory-medicine-serving-patients-for-70-years
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683507/critical-risk-results-an-update-on-international-initiatives
#17
Q Lam, E Ajzner, C A Campbell, A Young
Direct communication of significant (often life-threatening) results is a universally acknowledged role of the pathology laboratory, and an important contributor to patient safety. Amongst the findings of a recent survey of 871 laboratories from 30 countries by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM), only 3 tests were noted to be common to 90% of alert lists, and only 48% of laboratories consulted clinicians in developing these alert lists despite ISO15189 recommendations to do so...
February 2016: EJIFCC
https://www.readbyqxmd.com/read/27683506/opinion-paper-deriving-harmonised-reference-intervals-global-activities
#18
Jillian R Tate, Gus Koerbin, Khosrow Adeli
Harmonisation of reference intervals (RIs) refers to use of the same or common RI across different platforms and /or assays for a specified analyte. It occurs optimally for those analytes where there is sound calibration and traceability in place and evidence from a between-method comparison shows that bias would not prevent the use of a common RI. The selection of the RI will depend on various sources of information including local formal RI studies, published studies from the literature, laboratory surveys, manufacturer's product information, relevant guidelines, and mining of databases...
February 2016: EJIFCC
https://www.readbyqxmd.com/read/27683505/harmonization-of-clinical-laboratory-test-results-the-role-of-the-ivd-industry
#19
Dave Armbruster, James Donnelly
At the start of the 21st century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be more carefully applied to the in vitro diagnostic (IVD) community, that is, manufacturers. A new appreciation of calibrator traceability evolved. Although metrological traceability always existed, it was less detailed and formal. The In Vitro Diagnostics Directive (IVDD) of 2003 required manufacturers to provide traceability information, proving assays were anchored to internationally accepted reference materials and/or reference methods...
February 2016: EJIFCC
https://www.readbyqxmd.com/read/27683504/the-international-consortium-for-harmonization-of-clinical-laboratory-results-ichclr-a-pathway-for-harmonization
#20
Gary L Myers, W Greg Miller
Results from clinical laboratory measurement procedures must be equivalent to enable effective use of clinical guidelines for disease diagnosis and patient management. Analytical results that are harmonized and independent of the measurement system, time, and location of testing is essential for providing adequate patient care. The key to generating harmonized results is establishing traceability to an accepted reference standard where available. Awareness of the benefits of having traceable measurement results that are harmonized has increased along with efforts to develop approaches to enable and facilitate the implementation of harmonization...
February 2016: EJIFCC
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