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EJIFCC

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https://www.readbyqxmd.com/read/28149267/successful-iso-15189-accreditation-in-the-bethzatha-advanced-medical-laboratory-in-ethiopia
#1
Nardos Abebe
No abstract text is available yet for this article.
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149266/national-external-quality-assurance-program-pakistan-neqapp-a-milestone-in-proficiency-testing-in-pakistan
#2
Muhammad Usman Munir, Aamir Ijaz
OBJECTIVE: The objective of this study was to highlight current status and importance of National External Quality Assurance Program Pakistan (NEQAPP). Study Design: Cross sectional study. PLACE AND DURATION OF STUDY: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP) from August to October 2015. METHODS: The study data was extracted from electronic NEQAPP database. Results from 2014-2015 were evaluated for clinical chemistry, hematology, microbiology, and immunoassay programs...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149265/progress-in-metabolomics-standardisation-and-its-significance-in-future-clinical-laboratory-medicine
#3
Daniel A Dias, Therese Koal
Today, the technology of 'targeted' based metabolomics is pivotal in the clinical analysis workflow as it provides information of metabolic phenotyping (metabotypes) by enhancing our understanding of metabolism of complex diseases, biomarker discovery for disease development, progression, treatment, and drug function and assessment. This review is focused on surveying and providing a gap analysis on metabolic phenotyping with a focus on targeted based metabolomics from an instrumental, technical point-of-view discussing the state-of-the-art instrumentation, pre- to post- analytical aspects as well as an overall future necessity for biomarker discovery and future (pre-) clinical routine application...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149264/serum-insulin-like-growth-factor-i-quantitation-by-mass-spectrometry-insights-for-protein-quantitation-with-this-technology
#4
Richard Kin Ting Kam, Chung Shun Ho, Michael Ho Ming Chan
Liquid chromatography mass spectrometry (LC-MS) is a widely used technique in the clinical laboratory, especially for small molecule quantitation in biological specimens, for example, steroid hormones and therapeutic drugs. Analysis of circulating macromolecules, including proteins and peptides, is largely dominated by traditional enzymatic, spectrophotometric, or immunological assays in clinical laboratories. However, these methodologies are known to be subjected to interfering substances, for example heterophilic antibodies, as well as subjected to non-specificity issues...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149263/advantages-and-challenges-of-dried-blood-spot-analysis-by-mass-spectrometry-across-the-total-testing-process
#5
Rosita Zakaria, Katrina J Allen, Jennifer J Koplin, Peter Roche, Ronda F Greaves
INTRODUCTION: Through the introduction of advanced analytical techniques and improved throughput, the scope of dried blood spot testing utilising mass spectrometric methods, has broadly expanded. Clinicians and researchers have become very enthusiastic about the potential applications of dried blood spot based mass spectrometric applications. Analysts on the other hand face challenges of sensitivity, reproducibility and overall accuracy of dried blood spot quantification. In this review, we aim to bring together these two facets to discuss the advantages and current challenges of non-newborn screening applications of dried blood spot quantification by mass spectrometry...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149262/mass-spectrometry-applications-for-toxicology
#6
Michael M Mbughuni, Paul J Jannetto, Loralie J Langman
Toxicology is a multidisciplinary study of poisons, aimed to correlate the quantitative and qualitative relationships between poisons and their physiological and behavioural effects in living systems. Other key aspects of toxicology focus on elucidation of the mechanisms of action of poisons and development of remedies and treatment plans for associated toxic effects. In these endeavours, Mass spectrometry (MS) has become a powerful analytical technique with a wide range of application used in the Toxicological analysis of drugs, poisons, and metabolites of both...
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149261/recent-advances-in-the-clinical-application-of-mass-spectrometry
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
December 2016: EJIFCC
https://www.readbyqxmd.com/read/28149260/foreword-of-the-editor
#8
(no author information available yet)
No abstract text is available yet for this article.
December 2016: EJIFCC
https://www.readbyqxmd.com/read/27683538/emerging-and-disruptive-technologies
#9
Larry J Kricka
Several emerging or disruptive technologies can be identified that might, at some point in the future, displace established laboratory medicine technologies and practices. These include increased automation in the form of robots, 3-D printing, technology convergence (e.g., plug-in glucose meters for smart phones), new point-of-care technologies (e.g., contact lenses with sensors, digital and wireless enabled pregnancy tests) and testing locations (e.g., Retail Health Clinics, new at-home testing formats), new types of specimens (e...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683537/st2-and-galectin-3-ready-for-prime-time
#10
Wouter C Meijers, A Rogier van der Velde, Rudolf A de Boer
ST2 and galectin-3 are emerging biomarkers in the field of heart failure and have been extensively studied, and that whether they provide additional prognostic value on top of the clinical models and the gold standard in HF, (NT-pro)BNP. Our aim was to provide a comprehensive review of these emerging HF-related biomarkers in chronic, acute and incident heart failure. Regardless of the type of heart failure, both biomarkers seem to have an additional effect on top of the clinical model including natriuretic peptides...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683536/soluble-st2-and-galectin-3-what-we-know-and-don-t-know-analytically
#11
Thomas Mueller, Benjamin Dieplinger
The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of both analytes...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683535/high-sensitivity-cardiac-troponin-assays-how-to-implement-them-successfully
#12
Frederick K Korley, Allan S Jaffe
High sensitivity troponin (hsTn) assays provide an unprecedented opportunity to improve the detection and treatment of cardiac injury from coronary and non-coronary causes. They may also play a role in guiding the primary and secondary prevention of cardiovascular disease. However, to derive maximal benefit from their use, careful planning for the implementation of these new assays is required. In this manuscript, we will discuss actions that can be taken during hsTn pre-implementation, implementation and post-implementation phases...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683534/can-natriuretic-peptides-be-used-to-guide-therapy
#13
Antoni Bayes-Genis, Josep Lupón, Allan S Jaffe
Over the last 15 years, the hypothesis that intensified treatment directed at reducing natriuretic peptide (NP) concentrations may improve the outcomes of patients with heart failure (HF) has been scrutinized in several prospective clinical trials, with conflicting results. Collectively, however, the data suggest that NP concentrations may be useful in guiding HF management and improving HF-related morbidity and mortality. In this review, we summarize the existing data investigating the use of NPs as targets for outpatient HF therapy...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683533/analytical-issues-with-natriuretic-peptides-has-this-been-overly-simplified
#14
Alexander G Semenov, Alexey G Katrukha
Natriuretic peptides (NPs) were first described as cardiac biomarkers more than two decades ago. Since that time, numerous studies have confirmed NPs' diagnostic and prognostic utilities as biomarkers of myocardial function. However, we must now admit that despite the NPs' relatively long period of use in clinical practice, our understanding of the biochemistry and the variety of circulating forms of NPs, as well as of their potential as biomarkers, remains far from being complete and comprehensive. The highly complex nature and wide diversity of circulating forms of NPs make their accurate measurements in plasma far more complex than initially believed...
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683532/the-world-is-changing-are-we-ready
#15
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683531/foreword-of-the-editor
#16
(no author information available yet)
No abstract text is available yet for this article.
August 2016: EJIFCC
https://www.readbyqxmd.com/read/27683529/adding-value-in-the-postanalytical-phase
#17
Éva Ajzner
Apart from maintaining the highest quality of analytical test results, laboratories are now getting more focused on how to achieve the greatest impact of laboratory results on their patient's outcome. Laboratory professionals are now in the learning phase of implementing new practices at different steps of the extra-analytical phases of the testing process where laboratories used to contribute seldom, only sporadically. Recently, the achievable levels of harmonization and responsible contributors at various steps of the testing process have also been proposed...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683528/clinical-laboratories-production-factories-or-specialized-diagnostic-centers
#18
János Kappelmayer, Judit Tóth
Since a large proportion of medical decisions are based on laboratory results, clinical laboratories should meet the increasing demand of clinicians and their patients. Huge central laboratories may process over 10 million tests annually; they act as production factories, measuring emergency and routine tests with sufficient speed and accuracy. At the same time, they also serve as specialized diagnostic centers where well-trained experts analyze and interpret special test results. It is essential to improve and constantly monitor this complex laboratory service, by several methods...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683527/interpretation-of-blood-microbiology-results-function-of-the-clinical-microbiologist
#19
Katalin Kristóf, Júlia Pongrácz
The proper use and interpretation of blood microbiology results may be one of the most challenging and one of the most important functions of clinical microbiology laboratories. Effective implementation of this function requires careful consideration of specimen collection and processing, pathogen detection techniques, and prompt and precise reporting of identification and susceptibility results. The responsibility of the treating physician is proper formulation of the analytical request and to provide the laboratory with complete and precise patient information, which are inevitable prerequisites of a proper testing and interpretation...
April 2016: EJIFCC
https://www.readbyqxmd.com/read/27683526/deficiencies-of-the-natural-anticoagulants-novel-clinical-laboratory-aspects-of-thrombophilia-testing
#20
Zsuzsanna Bereczky, Réka Gindele, Marianna Speker, Judit Kállai
Venous thrombosis is a typical common complex disease as acquired and genetic causes play a role in its development. The different "loss of function" mutations of the natural anticoagulant system lead to antithrombin (AT), protein C (PC) and protein S (PS) deficiencies. Since thrombophilia testing has high cost and it has several methodological issues (analytical, pre-analytical), which makes the interpretation of results difficult, considerations should be made on the indications of testing, on the parameters that are measured and on the best available method to use...
April 2016: EJIFCC
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