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EJIFCC

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https://www.readbyqxmd.com/read/30050399/vitamin-b12-immunoassay-interference-in-a-patient-with-multiple-myeloma-troubleshooting-in-a-two-step-reagent-kit-based-on-enhanced-chemiluminescence-testing
#1
V Pant, A Tumbapo, B Kumar Yadav
Immunoassays are widely used for quantification of serum analytes however they are subjected to interference by endogenous antibodies. The laboratory procedures used to identify these endogenous antibodies is the demonstration of response to dilution or use of nonimmunoglobulin protein to block the interfering antibodies or the use of an alternate immunoassay. We report a clinical-diagnostic situation where serum vitamin B12 determination was interfered in an immunoassay due to excess of endogenous antibodies from monoclonal gammopathy that resulted in excess of analyte concentration...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050398/acute-myeloid-leukemia-with-severe-coagulation-disorder-and-concomitant-central-nervous-system-bleeding-a-clinical-diagnostic-case-report
#2
S Hatzl, B Uhl, M Hinterramskogler, S Leber, F Eisner, M Haring, P Jud
We report a case of severe central nervous system bleeding in a patient with acute monocytic leukemia. The patient was admitted to our emergency department because of massive back pain and positive meningeal signs. MR imaging yielded a spontaneous epidural hematoma of the thoracic vertebral column. Coagulation studies revealed fibrinogen levels below the linear measuring range and blood smears showed myeloid blast cells in the peripheral blood. The diagnosis of acute monocytic leukemia was confirmed by flow cytometric analysis...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050397/prevalence-of-anemia-and-its-associated-factors-among-children-in-ethiopia-a-protocol-for-systematic-review-and-meta-analysis
#3
Zegeye Abebe, Wubet Worku Takele, Degefaye Zelalem Anlay, Daniale Tekelia Ekubagewargies, Zegeye Getaneh, Molla Abebe, Mulugeta Melku
Background: Anemia is one of the global public health problems that affect more than one third of the world population. It has been strongly associated with poor growth and development, limited psychomotor development, and poor long-term performance in cognitive, social, and emotional functioning in children. There is not a single national figure about childhood anemia in Ethiopia. There is also inconclusive evidence about factors associated with anemia. Moreover, the present meta-analysis will generate concrete evidence in which the result may urge policy makers and program managers to design appropriate intervention to control childhood anemia...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050396/practical-guide-for-identifying-unmet-clinical-needs-for-biomarkers
#4
Phillip J Monaghan, Sarah Robinson, Daniel Rajdl, Patrick M M Bossuyt, Sverre Sandberg, Andrew St John, Maurice O'Kane, Lieselotte Lennartz, Ralf Röddiger, Sarah J Lord, Christa M Cobbaert, Andrea R Horvath
The development and evaluation of novel biomarkers and testing strategies requires a close examination of existing clinical pathways, including mapping of current pathways and identifying areas of unmet need. This approach enables early recognition of analytical and clinical performance criteria to guide evaluation studies, in a cyclical and iterative manner, all the time keeping the clinical pathway and patient health outcomes as the key drivers in the process. The Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM TE-WG) https://www...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050395/laboratory-aspects-and-clinical-utility-of-bone-turnover-markers
#5
Harjit Pal Bhattoa
With an aging population, there is a marked increase in prevalence of metabolic bone diseases, especially osteoporosis. Perhaps the most dreaded complication of metabolic bone disease, fractures typically impose a huge burden on the ailing body and are associated with high co-morbidity and mortality. The consequent public health and socioeconomic burden warrant timely diagnosis, treatment and follow-up of these disorders. Knowing the limitations of radiological techniques, biochemical markers of bone turnover measurements come handy since the changes in their levels readily reflect bone physiology...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050394/vitamin-d-and-endocrine-disorders-routine-laboratory-diagnostic-implications
#6
Giovanna Muscogiuri, Harjit Pal Bhattoa
The role of vitamin D in calcium-phosphorus metabolism regulation is the most highlighted, nonetheless there is enormous literature on the extra-skeletal effects of vitamin D, and lately new insight into the role of vitamin D in endocrine disease mechanisms has seen light of day. The present narrative review gives an overview of the proposed roles of vitamin D in the etiology of Hashimoto's thyroiditis, Grave's disease, Addison's disease and primary hyperthyroidism. The implications as pertaining to the routine laboratory practice are readily applicable to this patient group as well, and do not pose any additional challenge...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050393/vitamin-d-and-its-metabolites-from-now-and-beyond
#7
Etienne Cavalier, Jean-Claude Souberbielle
Total 25-hydroxyvitamin D is currently considered as the most representative metabolite of vitamin D status. There are a multitude of challenges that still deserve to be addressed and despite recent technological advances its determination remains complicated. This current review gives an abbreviated overview of the phases of development that vitamin D metabolite determination has gone through and discusses the difficulties that still require resolving. Furthermore, given the different platforms and methodologies available, the critical issue of standardization and all efforts made as far towards its realization have been discussed...
July 2018: EJIFCC
https://www.readbyqxmd.com/read/30050392/laboratory-investigation-of-vitamin-d-metabolites-and-bone-metabolism-markers
#8
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 2018: EJIFCC
https://www.readbyqxmd.com/read/29765288/serum-ferritin-as-a-biomarker-of-polycythemia-vera
#9
EDITORIAL
Stephen E Langabeer
No abstract text is available yet for this article.
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765287/the-ifcc-curriculum-phase-1
#10
Ronda F Greaves, Janet M Smith, Graham Beastall, Chris Florkowski, Loralie Langman, Joanna Sheldon, Elvar Theodorsson
No abstract text is available yet for this article.
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765286/reference-intervals-for-a-complete-blood-count-on-an-automated-haematology-analyser-sysmex-xn-in-healthy-adults-from-the-southern-metropolitan-area-of-barcelona
#11
Ariadna Arbiol-Roca, Claudia Elizabeth Imperiali, Magdalena Macià Montserrat, Ana Sancho Cerro, Anna Cortés Bosch de Basea, Lourdes Sánchez Navarro, Dolors Dot Bach, José Valero Politi
Background: The examination of peripheral blood is routinely used as a basic test in daily medical practice. Reliable reference intervals are necessary to avoid misdiagnoses, and the establishment of those intervals is an important task for clinical laboratories.The aim of the present study was to establish the reference intervals for complete blood count (CBC) on a Sysmex XN haematology analyser in healthy adults from the southern metropolitan area of Barcelona (Spain). Methods: A total of 213 apparently healthy adults who received a general health examination at Hospital Universitari de Bellvitge were recruited to this study...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765285/anemia-and-thrombocytopenia-in-the-cohort-of-hiv-infected-adults-in-northwest-ethiopia-a-facility-based-cross-sectional-study
#12
Tekalign Deressa, Debasu Damtie, Meseret Workineh, Meaza Genetu, Mulugeta Melku
Background: Anemia and thrombocytopenia are frequent hematological abnormalities in patients with human immunodeficiency virus (HIV) infection and have been associated with increased morbidity and mortality. However, there is a paucity of data on the prevalence and correlates of these hematological abnormalities among HIV infected adults in Ethiopia. The aim of this study was to determine the prevalence and correlates of anemia and thrombocytopenia in a cohort of HIV-1 infected adults in northwest Ethiopia...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765284/influence-of-serum-leptin-levels-and-q223r-leptin-receptor-polymorphism-on-clinical-characteristic-of-patients-with-rheumatoid-arthritis-from-western-mexico
#13
Luis I Angel-Chávez, Elizabeth Ruelas-Cinco, Jorge Hernández-Bello, Elena Castro, Mirna Vázquez-Villamar, Isela Parra-Rojas, L Michele Brennan-Bourdon, Salvador Muñoz-Barrios, Celia Guerrero-Velázquez, José Francisco Muñoz-Valle
Objective: The aim of the present study was to evaluate the possible association between the Q223R Leptin receptor (LEPR) polymorphism (A>G; rs1137101) and leptin levels in patients with rheumatoid arthritis (RA) from Western Mexico. Methods: A cross-sectional study was performed with 70 RA patients and 74 controls subject (CS). Disease activity was evaluated using DAS28 score, the Q223R LEPR polymorphism was determined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and serum leptin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and rheumatoid factor (RF) were quantified...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765283/integration-of-multigene-panels-for-the-diagnosis-of-hereditary-retinal-disorders-using-next-generation-sequencing-and-bioinformatics-approaches
#14
Chiara Di Resta, Ivana Spiga, Silvia Presi, Stefania Merella, Giovanni Battista Pipitone, Maria Pia Manitto, Giuseppe Querques, Maurizio Battaglia Parodi, Maurizio Ferrari, Paola Carrera
In recent years, Next-Generation Sequencing (NGS) opened a new way for the study of pathogenic mechanisms and for molecular diagnosis of inherited disorders. In the present work, we focused our attention on the inherited retinal dystrophies (IRDs), a group of specific disorders of the retina, displaying a very high clinical and genetic heterogeneity, whose genetic diagnosis is not easily feasible. It represents a paradigmatic example for the integration of clinical and molecular examination toward precision medicine...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765282/next-generation-sequencing-approach-for-the-diagnosis-of-human-diseases-open-challenges-and-new-opportunities
#15
Chiara Di Resta, Silvia Galbiati, Paola Carrera, Maurizio Ferrari
The rapid evolution and widespread use of next generation sequencing (NGS) in clinical laboratories has allowed an incredible progress in the genetic diagnostics of several inherited disorders. However, the new technologies have brought new challenges. In this review we consider the important issue of NGS data analysis, as well as the interpretation of unknown genetic variants and the management of the incidental findings. Moreover, we focus the attention on the new professional figure of bioinformatics and the new role of medical geneticists in clinical management of patients...
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29765281/foreword-from-the-new-editor-in-chief
#16
EDITORIAL
János Kappelmayer
No abstract text is available yet for this article.
April 2018: EJIFCC
https://www.readbyqxmd.com/read/29333152/erratum-1-pediatric-obesity-and-cardiometabolic-disorders-risk-factors-and-biomarkers
#17
E Levy, A K Saenger, M W Steffes, E Delvin
[This corrects the article on p. 6 in vol. 28, PMID: 28439216.].
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333151/lab-test-findings-in-the-elderly
#18
Barna Vásárhelyi, Lóránd A Debreczeni
No abstract text is available yet for this article.
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333150/evaluation-of-the-correlation-coefficient-of-polyethylene-glycol-treated-and-direct-prolactin-results-and-comparability-with-different-assay-system-results
#19
Shyamali Pal
The presence of Macro prolactin is a significant cause of elevated prolactin resulting in misdiagnosis in all automated systems. Poly ethylene glycol (PEG) pretreatment is the preventive process but such process includes the probability of loss of a fraction of bioactive prolactin. Surprisingly, PEG treated EQAS & IQAS samples in Cobas e 411 are found out to be correlating with direct results of at least 3 immunoassay systems and treated and untreated Cobas e 411 results are comparable by a correlation coefficient...
December 2017: EJIFCC
https://www.readbyqxmd.com/read/29333149/a-summary-of-worldwide-national-activities-in-chronic-kidney-disease-ckd-testing
#20
Roberto Ruiz-Arenas, Rosa Sierra-Amor, David Seccombe, Stella Raymondo, Maria Stella Graziani, Mauro Panteghini, Tewogbade A Adedeji, Shanthi Naidu Kamatham, Vanja Radišić Biljak
Chronic kidney disease (CKD) is a major public health issue worldwide and is associated with adverse health outcomes, especially in low- and middle-income countries. In a cash limited healthcare system, guidelines that improve the efficiency of health care free up resources needed for other healthcare services. This short review presents some examples from national acitivities in CKD testing, including countries throughout the globe: Mexico in North America, Uruguay in South America, Italy in Europe, Nigeria in Africa and India in Asia...
December 2017: EJIFCC
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