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ACS Omega

Zhiyong Song, Huajuan Wang, Yang Wu, Jiangjiang Gu, Shuojun Li, Heyou Han
Combating bacterial pathogens has become a global concern, especially the emergence of drug-resistant bacteria have made conventional antibiotics lose their efficiency. This grim situation suggests the necessity to explore novel antibacterial agents with favorable safety and strong antibacterial activity. Here, we took the advantage of quaternary ammonium compounds and synthesized a long-chain high-molecular organic bis-quaternary ammonium salt (BQAS) with a broad-spectrum bactericidal activity through a facile one-pot reaction...
October 31, 2018: ACS Omega
Wen Chen, Junyan Han, Xiangnan Wang, Xianjun Liu, Feng Liu, Fenglin Wang, Ru-Qin Yu, Jian-Hui Jiang
Formaldehyde (FA), as a reactive carbonyl species and signaling molecule, plays an important role in living systems. Here, an FA-responsive probe with fast response and great selectivity is designed based on aggregation-induced emission. The probe is prepared by functionalizing tetraphenylethene (TPE) with two amine groups. FA is detected based on the solubility differences between the amine-functionalized TPE and the corresponding Schiff bases after reaction with FA. The probe exhibits a limit of detection of 40 nM and a response time of ∼90 s...
October 31, 2018: ACS Omega
Maduraimuthu Djanaguiraman, Remya Nair, Juan Pablo Giraldo, Pagadala Venkata Vara Prasad
Drought is a major abiotic stress affecting crop growth and yield worldwide. Drought-induced oxidative stress results in the reduction of plant photosynthesis and reproductive success. Cerium oxide nanoparticles (nanoceria) possess potent antioxidant properties that can alleviate drought-induced oxidative stress by catalytic scavenging reactive oxygen species (ROS), thereby protecting sorghum [ Sorghum bicolor (L.) Moench ] photosynthesis and grain yield. Drought was imposed at the booting stage by withholding water for 21 d...
October 31, 2018: ACS Omega
Upasana Das, Aditi Sahoo, Subhash Haldar, Sudin Bhattacharya, Syam Sundar Mandal, William H Gmeiner, Supratim Ghosh
We investigate the physicochemical interactions of gold nanorod (GNR) with single-stranded, double-stranded, and hairpin DNA structures to improve the biological compatibility as well as the therapeutic potential, including the photothermal effect of the conjugates. Studies have demonstrated that different DNA secondary structures, containing thiol group, have different patterns of physicochemical interaction. Conjugation efficiency of paired oligonucleotides are significantly higher than that of oligonucleotides with naked bases...
October 31, 2018: ACS Omega
Redouane Bouchaala, Ludovic Richert, Nicolas Anton, Thierry F Vandamme, Smail Djabi, Yves Mély, Andrey S Klymchenko
Understanding the release of drugs and contrast agents from nanocarriers is fundamental in the development of new effective nanomedicines. However, the commonly used method based on dialysis frequently fails to quantify the release of molecules poorly soluble in water, and it is not well-suited for in situ measurements in biological media. Here, we have developed a new methodology for quantifying the release of fluorescent molecules from lipid nanocarriers (LNCs) using fluorescence correlation spectroscopy (FCS)...
October 31, 2018: ACS Omega
Kurt W E Sy Piecco, Ahmed M Aboelenen, Joseph R Pyle, Juvinch R Vicente, Dinesh Gautam, Jixin Chen
Thiol-ene click chemistry has become a powerful paradigm in synthesis, materials science, and surface modification in the past decade. In the photoinitiated thiol-ene reaction, an induction period is often observed before the major change in its kinetic curve, for which a possible mechanism is proposed in this report. Briefly, light soaking generates radicals following the zeroth-order reaction kinetics. The radical is the reactant that initializes the chain reaction of thiol-ene coupling, which is a first-order reaction...
October 31, 2018: ACS Omega
Noga Yaakov, Karthik Ananth Mani, Reut Felfbaum, Magen Lahat, Noam Da Costa, Eduard Belausov, Dana Ment, Guy Mechrez
A new approach for single cell microencapsulation in an oil-in-water (o/w) Pickering emulsion is presented. The water/paraffin emulsions were stabilized by amine-functionalized silica nanoparticles. The droplet size of the emulsions was highly tunable, and ranged from 1 to 30 μm in diameter. The controllable droplet size along with the high colloidal stability of the Pickering emulsionswas harnessed to obtain single cell microencapsulation. Successful encapsulation of the conidia entomopathogenic fungus Metarhizium brunneum by the studied Pickering emulsions was confirmed via confocal laser scanning microscopy...
October 31, 2018: ACS Omega
Shivnetra Saha, Mohammad Ashhar Iqbal Khan, Deepak Mudhara, Shashank Deep
The aggregates of α-synuclein bear a close connection with Parkinson's disease, which is largely characterized by the loss of the dopaminergic neurons. Dopamine promotes the formation of undesirable sodium dodecyl sulfate (SDS)-resistant oligomers of α-synuclein. In this study, we have shown that the inhibition of fibrillation by an additive may not always be the ultimate deciding factor in the context of its potential as a successful additive. Copper promotes the fibrillation of α-synuclein in buffer alone but inhibits the formation of SDS-resistant oligomers in the presence of dopamine...
October 31, 2018: ACS Omega
Li Zhang, Xuemeng Li, Yangyang Wang, Kang Sun, Xuexian Chen, Huanjun Chen, Jianhua Zhou
Localized surface plasmon resonance (LSPR) biosensors show great potential for practical/commercial use in clinical diagnosis, home healthcare, environmental analysis, and public healthcare. However, two main issues, that is, low refractometric sensitivity and low reproducibility (large-area uniformity and batch-to-batch consistency), hinder the extensive applications of LSPR biosensors. Therefore, plasmonic nanostructures with high sensitivity and excellent reproducibility are desirable for preparing reliable LSPR sensors...
October 31, 2018: ACS Omega
Naima Ali, Jennifer Marsh, Simon Godfrey, Daryl R Williams
The sorption of aqueous monoethanolamine (MEA) and ammonia solutions in keratin fibers and its subsequent effect on their mechanical performance has been investigated. The diffusion kinetics of MEA into keratin fibers for 0.1, 1.0, and 5 v/v % MEA in water at 30 and 50 °C were found to exhibit two clear regimes of absorption behavior: a linear Fickian diffusion regime for initial times up to 100 min, after which a second slower uptake process was observed. Single fiber tensile tests showed that the Young's modulus and the tensile failure stress for 5% MEA-treated fibers, compared to untreated fibers, were 25% lower after 1 h of treatment and 50% lower after 9 h of treatment...
October 31, 2018: ACS Omega
Mathew R Schnorenberg, Sang Pil Yoo, Matthew V Tirrell, James L LaBelle
Despite the therapeutic promise of phospholipid-based nanocarriers, a major obstacle to their widespread clinical translation is a susceptibility to fatty acid ester hydrolysis, leading to lack of quality control and inconsistencies in self-assembly formulations. Using electrospray ionization mass spectrometry fragmentation in combination with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, we have demonstrated a method to detect hydrolysis of one or both of the fatty acid esters in a PEGylated phospholipid, DSPE-PEG, in conditions commonly applied during nanocarrier production...
October 31, 2018: ACS Omega
Sean D Kodani, Debin Wan, Karen M Wagner, Sung Hee Hwang, Christophe Morisseau, Bruce D Hammock
Fatty acid amide hydrolase (FAAH) is responsible for regulating concentrations of the endocannabinoid arachidonoyl ethanolamide. Multiple FAAH inhibitors have been developed for clinical trials and have failed to demonstrate efficacy at treating pain, despite promising preclinical data. One approach toward increasing the efficacy of FAAH inhibitors is to concurrently inhibit other targets responsible for regulating pain. Here, we designed dual inhibitors targeting the enzymes FAAH and soluble epoxide hydrolase (sEH), which are targets previously shown to synergize at reducing inflammatory and neuropathic pain...
October 31, 2018: ACS Omega
Shanna Litau, Uwe Seibold, Björn Wängler, Ralf Schirrmacher, Carmen Wängler
The inverse electron demand Diels-Alder conjugation reaction has gained increasing importance over the past few years for efficient in vivo and ex vivo radiometal labeling of antibodies. However, the application of this very fast reaction type has not been studied for radiolabeling of peptides so far. We show here the synthesis of 3-benzyl-1,2,4,5-tetrazine-comprising ((1,4,7,10-tetraazacyclododecane-4,7,10-triyl)triacetic acid-1-glutaric acid) (DOTA-GA) and ((1,4,7-triazacyclononane-4,7-diyl)diacetic acid-1-glutaric acid) (NODA-GA) chelators and their radiometal labeling with 68 Ga3+ and 64 Cu2+ ...
October 31, 2018: ACS Omega
Eugénie Laigre, Claire Tiertant, David Goyard, Olivier Renaudet
Carbohydrate-protein interactions play key roles in a wide variety of biological processes. These interactions are usually weak, with dissociation constants in the low millimolar to high micromolar range. Nature uses multivalency to reach high avidities via the glycoside cluster effect. Capitalizing on this effect, numerous synthetic multivalent glycoconjugates have been described and used as ligands for carbohydrate-binding proteins. However, valency is only one of the several parameters governing the binding mechanisms that are different for every biological receptor, making it almost impossible to predict...
October 31, 2018: ACS Omega
Katelyn Rose Bittleman, Shuping Dong, Maren Roman, Yong Woo Lee
The study evaluates cellulose nanocrystals (CNCs) as nanocarriers for targeted, intracellular delivery of molecular agents. CNCs were labeled with fluorescein-5'-isothiocyanate as an imaging agent and conjugated to folic acid (FA) as a targeting ligand. The CNC conjugates were characterized by UV-vis spectroscopy, ζ-potential analysis, dynamic light scattering, and atomic force microscopy. Cellular binding/uptake of the FA-conjugated CNCs by KB and MDA-MB-468 cells was quantified with cellular uptake assays...
October 31, 2018: ACS Omega
Kengo Arai, Yoshiki Horikawa, Toshiyuki Shikata
A cellulose nanocrystal (CNC) sample prepared from chemical pulp via sulfuric acid hydrolysis procedures has been supplied by InnoTech Alberta Inc. in the shape of white dry powder as a prototype product. Some transport coefficients were precisely investigated for the CNC sample in aqueous suspensions at the room temperature of 25 °C such as the average rotational and translational diffusion coefficients ( D r and D t ) and viscoelastic relaxation times (τv ) at dilute conditions. The determined values, D r ≈ 2...
October 31, 2018: ACS Omega
Alexandre Moquin, Jeff Ji, Kevin Neibert, Françoise M Winnik, Dusica Maysinger
Polymersomes are attractive nanocarriers for hydrophilic and lipophilic drugs; they are more stable than liposomes, tunable, and relatively easy to prepare. The copolymer composition and molar mass are critical features that determine the physicochemical properties of the polymersomes including the rate of drug release. We used the triblock-copolymer, poly(2-methyl-2-oxazoline)- block -poly-(dimethysiloxane)- block -poly(2-methyl-2-oxazoline) (PMOXA-PDMS-PMOXA), to form amphipathic polymersomes capable of loading proteins and small hydrophobic agents...
October 31, 2018: ACS Omega
Rajendra Goswami, Jasper Marc G Bondoc, Paul R Wheeler, Alireza Jafari, Trinidad Gonzalez, Shahila Mehboob, Farahnaz Movahedzadeh
Inositol monophosphatase (IMPase) is a crucial enzyme for the biosynthesis of phosphatidylinositol, an essential component in mycobacterial cell walls. IMPase A (ImpA) from Mycobacterium smegmatis is a bifunctional enzyme that also functions as a fructose-1,6-bisphosphatase (FBPase). To better understand the bifunctional nature of this enzyme, point mutagenesis was conducted on several key residues and their enzyme activity was tested. Our results along with active site models support the fact that ImpA is a bifunctional enzyme with residues Gly94, Thr95 hypothesized to be contributing to the FBPase activity and residues Trp220, Asp221 hypothesized to be contributing to the IMPase activity...
October 31, 2018: ACS Omega
Guilherme Colherinhas, Thaciana Malaspina, Eudes Eterno Fileti
The development of green and biodegradable electrical components is one of the main fronts of research to overcome the growing ecological problem related to the issue of electronic waste. At the same time, such devices are highly desirable in biomedical applications such as integrated bioelectronics, for which biocompatibility is also required. Supercapacitors for storage of electrochemical energy, designed only with biodegradable organic matter would contemplate both aspects, that is, they would be ecologically harmless after their service lifetime and would be an important component for applications in biomedical engineering...
October 31, 2018: ACS Omega
Sarah E Dowd, Martina L Mustroph, Elena V Romanova, Bruce R Southey, Heinrich Pinardo, Justin S Rhodes, Jonathan V Sweedler
Recent research suggests that exercise may help facilitate abstinence from cocaine addiction, though the mechanisms are not well understood. In mice, wheel running accelerates the extinction of conditioned place preference (CPP) for cocaine, providing an animal model for evaluating potential neurological mechanisms. The objective of this study was to quantify dynamic changes in endogenous peptides in the amygdala and dentate gyrus of the hippocampus in mice exposed to a context paired with the effects of cocaine, and in response to exercise...
October 31, 2018: ACS Omega
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