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ACS Omega

Somenath Lohar, Koushik Dhara, Priya Roy, Santi P Sinha Babu, Pabitra Chattopadhyay
A newly designed cyanide-selective chemosensor based on chromone containing benzothiazole groups [3-(2,3-dihydro-benzothiazol-2-yl)-chromen-4-one ( DBTC) ] was synthesized and structurally characterized by physico-chemical, spectroscopic, and single-crystal X-ray diffraction analyses. The compound DBTC can detect cyanide anions based on nucleophilic addition as low as 5.76 nM in dimethyl sulfoxide- N -(2-hydroxyethyl)piperazine- N '-ethanesulfonic acid buffer (20 mM, pH 7.4) (v/v = 1:3). The binding mode between receptor DBTC and cyanide nucleophile has also been demonstrated by experimental studies using various spectroscopic tools and theoretical studies, and the experimental work has also been verified by characterizing one supporting compound of similar probable structure of the final product formed between DBTC and cyanide ion ( DBTC-CN compound) by single-crystal X-ray analysis for detailed structural analyses...
August 31, 2018: ACS Omega
Emma M McCarthy, Hayley Floyd, Owen Addison, Zhenyu J Zhang, Pola Goldberg Oppenheimer, Liam M Grover
Metals on metal implants have long been used in arthroplasties because of their robustness and low dislocation rate. Several relatively low-corrosion metals have been used in arthroplasty, including 316L stainless steel, titanium, and cobalt-chromium-molybdenum alloy. Debris from these implants, however, has been found to cause inflammatory responses leading to unexpected failure rates approaching 10% 7 years surgery. Safety assessment of these materials traditionally relies on the use of simple two-dimensional assays, where cells are grown on the surface of the material over a relatively short time frame...
August 31, 2018: ACS Omega
Jonathan Quinson, Laura Kacenauskaite, Troels L Christiansen, Tom Vosch, Matthias Arenz, Kirsten M Ø Jensen
Platinum nanocrystals with a fine control of the crystal domain size in the range 1.0-2.2 nm are produced by tuning the NaOH concentration during the UV-induced reduction of H2 PtCl6 in surfactant-free alkaline ethylene glycol. The colloidal solutions obtained are characterized by transmission electron microscopy and pair distribution function analysis, allowing analysis of both atomic and nanoscale structures. The obtained nanoparticles exhibit a face-centered cubic crystal structure even for the smallest nanoparticles, and the cubic unit cell parameter is significantly reduced with decreasing crystallite size...
August 31, 2018: ACS Omega
Mohammad Aghazadeh Meshgi, Kirill V Zaitsev, Mikhail V Vener, Andrei V Churakov, Judith Baumgartner, Christoph Marschner
The hypercoordinated silicon chlorides ClSi[( o -OC6 H4 )3 N] ( 3 ) and ClSi[(OC6 H2 Me2 CH2 )3 N] ( 5 ) were used for the synthesis of catenated derivatives (Me3 Si)3 SiSi[( o -OC6 H4 )3 N] ( 9 ), (Me3 Si)3 SiSiMe2 SiMe2 Si(SiMe3 )2 Si[( o -OC6 H4 )3 N] ( 11 ), and (Me3 Si)3 SiSi[(OC6 H2 Me2 CH2 )3 N] ( 13 ) in reactions with (Me3 Si)3 SiK·THF ( 7 ) or (Me3 Si)3 SiK·[18-crown-6] ( 8 ). It was found that the nature of the (Me3 Si)3 SiK solvate determines the product of interaction, resulting in the formation of (Me3 Si)3 Si(CH2 )4 OSi[(OC6 H2 Me2 CH2 )3 N] ( 12 ) or 13 ...
August 31, 2018: ACS Omega
Hao Minh Hoang, Van Thi Bich Pham, Günter Grampp, Daniel R Kattnig
Donor-acceptor systems forming exciplexes are versatile models for the study of magnetic field effects (MFEs) on charge recombination reactions. The MFEs originate from singlet-triplet interconversion within transient radical ion pairs (RIPs), which exist in a dynamic equilibrium with the exciplexes. Here, we describe the synthesis and MFEs of the chain-linked N , N -dimethylaniline (DMA)/9-methylanthracene (MAnt) donor-acceptor system MAnt-(CH2 ) n - O -CH2 -CH2 -DMA for n = 6, 8, 10, and 16. The MFEs are found to increase with increasing chain length...
August 31, 2018: ACS Omega
Chad M Gilmer, Ned B Bowden
This article reports the fabrication of organic solvent nanofiltration membranes containing a labile disulfide bond, which is broken by reaction with a chemical stimulus. These membranes are a new generation of smart membranes that have tailored selectivities and flux that can be altered by reacting with a chemical stimulus. The selectivity and flux of chemicals through the membranes was controlled by varying the concentration of disulfide bonds in the membrane. When the disulfide bonds were cleaved, the pores in the membrane became larger and yielded different separation properties...
August 31, 2018: ACS Omega
Sean W Reilly, Laura N Puentes, Chia-Ju Hsieh, Mehran Makvandi, Robert H Mach
Poly(ADP-ribose) polymerase inhibitors (PARPi) are targeted therapeutics with enhanced selectivity and cytotoxicity in BRCA1/2 mutant cancer cells. AZD2461, a congener of FDA approved olaparib, is a potent PARPi with high affinity for PARP-1 and nonsubstrate for P-glycoprotein (P-gp), an attractive characteristic for cancer therapeutics. Analogues of AZD2461 were synthesized and profiled in BRCA1 functional and nonfunctional cell lines, revealing compounds ( 2 , 3 , and 5 ) of low cytotoxicity and excellent PARP-1 affinities (∼4-8 nM)...
August 31, 2018: ACS Omega
David Benito-Alifonso, Barbara Richichi, Veronica Baldoneschi, Monica Berry, Marco Fragai, Gianluca Salerno, M Carmen Galan, Cristina Nativi
The practical synthesis of novel multivalent fluorescent quantum-dot-based probes to target cellular matrix metalloproteinases (MMPs) (MT-MMPs) is reported. We show that these probes, which are decorated with a nanomolar water-soluble MMP inhibitor, can be used to label preferentially the surface of cancer cells that are known to express MMPs while no binding was observed on cells that do not.
August 31, 2018: ACS Omega
Naemeh Aeineh, Andrés-Felipe Castro-Méndez, Pedro J Rodriguez-Cantó, Rafael Abargues, Ehsan Hassanabadi, Isaac Suarez, Abbas Behjat, Pablo Ortiz, Juan P Martínez-Pastor, Ivan Mora-Seró
In this work, SiO2 nanoparticles (NPs) were integrated into the mesoporous TiO2 layer of a perovskite solar cell to investigate their effect on cell performance. Different concentrations of SiO2 /ethanol have been combined in TiO2 /ethanol to prepare pastes for the fabrication of the mesoporous layer with which perovskite solar cells have been fabricated. Addition of SiO2 NPs of 50 and 100 nm sizes produces an enhancement of cell performance mainly because of an improvement of the photocurrent. This increment is in good agreement with the theoretical predictions based on light scattering induced by dielectric SiO2 NPs...
August 31, 2018: ACS Omega
R Aaron Rogers, Aaron M Fleming, Cynthia J Burrows
We have studied the in vitro stability of 25 potential i-motif-forming DNA sequences found within the promoter regions of 18 different human DNA repair genes. Three widely available methods of characterization were used to rapidly assess i-motif folding and stability and comprise a simple screen for preliminary identification of physiologically relevant i-motif forming sequences. Four highly pH-stable candidate sequences were identified exhibiting pH transitions (pH at which 50% of the oligodeoxynucleotides in solution are folded) at or above pH 6...
August 31, 2018: ACS Omega
Jianjun Pan, Annalisa Dalzini, Nawal K Khadka, Chinta M Aryal, Likai Song
Modulations of synaptic membranes play an essential role in the physiological and pathological functions of the presynaptic protein α-synuclein (αSyn). Here we used solution atomic force microscopy (AFM) and electron paramagnetic resonance (EPR) spectroscopy to investigate membrane modulations caused by αSyn. We used several lipid bilayers to explore how different lipid species may regulate αSyn-membrane interactions. We found that at a protein-to-lipid ratio of ∼1/9, αSyn perturbed lipid bilayers by generating semi-transmembrane defects that only span one leaflet...
August 31, 2018: ACS Omega
Megha Rajendran, Benjamin Claywell, Emily P Haynes, Umi Scales, Chace K Henning, Mathew Tantama
The regulation of pH is essential for proper organelle function, and organelle-specific changes in pH often reflect the dynamics of physiological signaling and metabolism. For example, mitochondrial energy production depends on the proton gradient maintained between the alkaline mitochondrial matrix and neutral cytosol. However, we still lack a quantitative understanding of how pH dynamics are coupled between compartments and how pH gradients are regulated at organelle boundaries. Genetically encoded pH sensors are well suited to address this problem because they can be targeted to specific subcellular locations and they facilitate live, single-cell analysis...
August 31, 2018: ACS Omega
Dona T L Galhena, Bernhard C Bayer, Jannik C Meyer, Stephan Hofmann, Gehan A J Amaratunga
Using reduced graphene oxide (r-GO) as a multifunctional conductive binder, a simple, cost-effective, and environmentally friendly approach is developed to fabricate activated carbon/reduced graphene oxide (AC/r-GO) composite electrodes for supercapacitors with outstanding performance. In such a composite, r-GO provides several much needed critical functions: r-GO not only serves as the binder material improving the AC particle/particle cohesion and electrode-film/substrate adhesion but also improves the electrical conductivity of the composite and provides additional surfaces for ion adsorption...
August 31, 2018: ACS Omega
Sreekanth Kokkonda, Farah El Mazouni, Karen L White, John White, David M Shackleford, Maria Jose Lafuente-Monasterio, Paul Rowland, Krishne Manjalanagara, Jayan T Joseph, Adolfo Garcia-Pérez, Jorge Fernandez, Francisco Javier Gamo, David Waterson, Jeremy N Burrows, Michael J Palmer, Susan A Charman, Pradipsinh K Rathod, Margaret A Phillips
Malaria kills nearly 0.5 million people yearly and impacts the lives of those living in over 90 countries where it is endemic. The current treatment programs are threatened by increasing drug resistance. Dihydroorotate dehydrogenase (DHODH) is now clinically validated as a target for antimalarial drug discovery as a triazolopyrimidine class inhibitor ( DSM265 ) is currently undergoing clinical development. We discovered a related isoxazolopyrimidine series in a phenotypic screen, later determining that it targeted DHODH...
August 31, 2018: ACS Omega
Song Lou, Zongmin Zhao, Micah Dezort, Taylor Lohneis, Chenming Zhang
By targeting CD44 receptors, inhibiting multidrug resistance (MDR), controlling drug release, and synergistically inhibiting tumor growth, a multilayered nanosystem was developed to serve as a multifunctional platform for the treatment of drug-resistant breast cancers. The multilayer nanosystem is composed of a poly(lactic- co -glycolic acid) core, a liposome second layer, and a chitosan third layer. The chitosan-multilayered nanoparticles (Ch-MLNPs) can co-deliver three chemotherapeutic agents: doxorubicin (DOX), paclitaxel (PTX), and silybin...
August 31, 2018: ACS Omega
Stefan Bitter, Marius Kunkel, Lisa Burkart, André Mang, Rainer F Winter, Sebastian Polarz
Surfactants are functional molecules comprising a water-compatible head group and a hydrophobic tail. One of their features is the formation of self-assembled structures in contact with water, for instance, micelles, vesicles, or lyotropic liquid crystals. One way to increase the functionality of surfactants is to implement moieties containing transition-metal species. Ferrocene-based surfactants represent an excellent example because of the distinguished redox features. In most existing ferrocene-based amphiphiles, an alkyl chain is classically used as the hydrophobic tail...
August 31, 2018: ACS Omega
Anastasia Psarra, Maroula G Kokotou, Gerasimia Galiatsatou, Varnavas D Mouchlis, Edward A Dennis, George Kokotos
Cytosolic phospholipase A2 (GIVA cPLA2 ) has attracted great interest as a medicinal target because it initiates the eicosanoid cascade and is involved in a number of inflammatory diseases. As a consequence, the development of potent synthetic inhibitors is of great importance. We have developed highly potent 2-oxoester inhibitors of GIVA cPLA2 presenting X I (50) values between 0.000019 and 0.000066. We demonstrate that the 2-oxoester functionality is essential for in vitro inhibitory activity, making these inhibitors useful research reagents...
August 31, 2018: ACS Omega
Fumihiro Kawai, Akihiko Nakamura, Akasit Visootsat, Ryota Iino
We evaluated a method for protein engineering using plasmid-based one-pot saturation mutagenesis and robot-based automated screening. When the biases in nucleotides and amino acids were assessed for a loss-of-function point mutation in green fluorescent protein, the ratios of gain-of-function mutants were not significantly different from the expected values for the primers among the three different suppliers. However, deep sequencing analysis revealed that the ratios of nucleotides in the primers were highly biased among the suppliers...
July 31, 2018: ACS Omega
Indrani Nandi, Sayantani Chall, Sourav Chowdhury, Tulika Mitra, Sib Sankar Roy, Krishnananda Chattopadhyay
Biomimetic synthesis of multifunctional fluorescent gold nanoclusters (Au NCs) is of great demand because of their ever-increasing applications. In this study, we have used self-assembled bovine serum albumin (BSA) amyloid-like nanofibers as the bioinspired scaffold for the synthesis of Au NCs. The amyloid fibril stabilized gold nanocluster (Fib-Au NC) has been found to have appreciable enhancement of fluorescence emission and a large 25 nm red shift in its emission maxima when compared to its monomeric protein counterpart (BSA-Au NC)...
July 31, 2018: ACS Omega
Samarth Bhargava, Justin Jang Hann Chu, Suresh Valiyaveettil
Polymer nanoparticles are used extensively in biomedical applications. Poly(methylmethacrylate) (PMMA) nanoparticles obtained via nanoprecipitation were unstable and flocculate or precipitate from solution within a few hours. A simple method to improve the stability of the particles using surfactants at low concentrations was carried out to produce PMMA nanoparticles with long-term stability in water (>6 months). The increased stability was attributed to the incorporation of surfactants inside the polymer particles during nanoprecipitation...
July 31, 2018: ACS Omega
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