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KI Reports

Pooja Singhal, Kevin Yi Mi Ren, Bryan M Curtis, Ian MacPherson, Carmen Avila-Casado
No abstract text is available yet for this article.
July 2018: KI Reports
Yuri Gorelik, Said Darawshi, Hiba Yaseen, Zaid Abassi, Samuel N Heyman, Mogher Khamaisi
Introduction: Acute kidney injury associated with near-drowning (ND-AKI) has rarely been reported and its incidence among survivors is unknown. A patient with AKI and urine biomarkers indicating tubular injury led us to assess the occurrence and clinical characteristics of ND-AKI and to evaluate possible causative mechanisms. Methods: We evaluated medical records of patients rescued from near-drowning in the Mediterranean Sea and treated in a tertiary-level medical center during 2000 to 2017...
July 2018: KI Reports
David W Ploth, Jessie K Mbwambo, Virginia A Fonner, Bruce Horowitz, Phillip Zager, Ron Schrader, Francis Fredrick, Caroline Laggis, Michael D Sweat
Introduction: Chronic kidney disease (CKD), diabetes, and hypertension play a disproportionate role in the growing public health challenge posed by noncommunicable diseases (NCDs) in East Africa. The impact of these NCDs may pose the greatest challenge in rural areas with limited screening and treatment facilities, although precise prevalence estimates of these conditions in rural Tanzania are lacking. Methods: The prevalence of CKD, diabetes, and hypertension, were estimated from a probability sample of adults (n = 739) residing in 2 communities within Kisarawe, a rural district of Tanzania...
July 2018: KI Reports
Borut Cizman, Andy P Sykes, Gitanjali Paul, Steven Zeig, Alexander R Cobitz
Introduction: Hyporesponsiveness to recombinant human erythropoietin (rhEPO) is a major problem affecting some patients with chronic kidney disease (CKD), predominantly those on hemodialysis (HD). Daprodustat (GSK1278863) is a hypoxia-inducible factor prolyl hydroxylase inhibitor that is being investigated as a treatment for anemia of CKD. Methods: This phase 2a, exploratory, multicenter, single-arm study assessed the ability of daprodustat to increase or maintain hemoglobin concentrations within the target range (10...
July 2018: KI Reports
Donal J Sexton, Declan G de Freitas, Mark A Little, Tomas McHugh, Colm Magee, Peter J Conlon, Conall M O'Seaghdha
We report 2 cases of apixaban use as prophylaxis against thromboembolism in the nephrotic syndrome (NS), and review the existing literature on direct-acting oral anticoagulant (DOAC) use in this scenario. Our cases appear to be the first reported use of apixaban as prophylaxis against thromboembolism in NS. We report our systematic review of the existing literature on direct-acting oral anticoagulant (DOAC) use in NS, and discuss theoretical issues relevant to their therapeutic use in this clinical scenario...
July 2018: KI Reports
Eric P Cohen, Jean-Marie Krzesinski
No abstract text is available yet for this article.
July 2018: KI Reports
Maria Meneghini, Edoardo Melilli, Jaume Martorell, Ignacio Revuelta, Elisabet Rigol-Monzó, Anna Manonelles, Nuria Montero, David Cucchiari, Fritz Diekmann, Josep M Cruzado, Salvador Gil-Vernet, Josep M Grinyó, Oriol Bestard
Introduction: Despite the different assays available for immune-risk stratification before living-donor kidney transplantation (LDKT), the precise type and number of tests to perform remain uncertain. Methods: In a cohort of 330 consecutive LDKT patients, all of which were complement-dependent cytotoxicity (CDC)-crossmatch negative, we retrospectively analyzed the impact on main clinical outcomes of most sensitive immunoassays (complement-dependent cytotoxicity-panel-reactive antibody [CDC-PRA], flow cytometry crossmatch [FC-XM], donor-specific antibodies [DSAs], and their complement-binding capacity DSA-C3d]), together with donor/recipient HLA eplet matching...
July 2018: KI Reports
Kevin Esmeijer, Johanna M Geleijnse, Johan W de Fijter, Erik J Giltay, Daan Kromhout, Ellen K Hoogeveen
Introduction: Impaired kidney function is a robust risk factor for cardiovascular mortality. Age-related annual kidney function decline of 1.0 ml/min per 1.73 m2 after age 40 years is doubled in post-myocardial infarction (MI) patients. Methods: We investigated the impact of the number of cardiovascular risk factors (including unhealthy lifestyle) on annual kidney function decline, in 2426 post-MI patients (60-80 years) of the prospective Alpha Omega Cohort study...
July 2018: KI Reports
Christopher J Pino, Angela J Westover, Kimberly A Johnston, Deborah A Buffington, H David Humes
Regenerative medicine was initially focused on tissue engineering to replace damaged tissues and organs with constructs derived from cells and biomaterials. More recently, this field of inquiry has expanded into exciting areas of translational medicine modulating the body's own endogenous processes, to prevent tissue damage in organs and to repair and regenerate these damaged tissues. This review will focus on recent insights derived from studies in which the manipulation of the innate immunologic system may diminish acute kidney injury and enhance renal repair and recovery without the progression to chronic kidney disease and renal failure...
July 2018: KI Reports
Toralf Melsom, Marit Dahl Solbu, Jørgen Schei, Vidar Tor Nyborg Stefansson, Jon Viljar Norvik, Trond Geir Jenssen, Tom Wilsgaard, Bjørn Odvar Eriksen
Introduction: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, cardiovascular, or chronic kidney disease. Methods: In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1567 middle-aged nondiabetic individuals with an ACR <3...
July 2018: KI Reports
Csaba P Kovesdy, Jun Ling Lu, Barry M Wall, Geeta Gyamlani, Adnan Naseer, Angela Wallick, Zhongji Han, Fridtjof Thomas, L Darryl Quarles, Nabil Jarmukli
Introduction: Abnormal phosphorus homeostasis develops early in chronic kidney disease (CKD). It is unclear if its correction results in improved clinical outcomes in non-dialysis dependent CKD. Methods: We conducted a randomized controlled, parallel design clinical trial in 120 patients with estimated glomerular filtration rate 15 to 59 ml/min per 1.73 m2 and abnormal phosphorus homeostasis (serum phosphorus >4.6 mg/dl, parathyroid hormone [PTH] >70 pg/ml or tubular reabsorption of phosphorus [TRP] <80%)...
July 2018: KI Reports
Pingping Yang, Honghong Zou, Bufan Xiao, Gaosi Xu
The present study aims to compare the relative efficacy and safety of different interventions for IgA nephropathy (IgAN) with proteinuria more than 1 g/d by using network meta-analysis. We searched PubMed, Embase, and the Cochrane Library for studies compared the rate of clinical remission and/or end-stage renal disease (ESRD) and/or serious adverse events in IgAN patients with proteinuria (>1 g/d). The surface under the cumulative ranking area (SUCRA) was calculated to rank the interventions. A total of 21 randomized controlled trials with 1822 participants were included for the comparisons of 7 interventions...
July 2018: KI Reports
Oksana Harasemiw, Shannon Milks, Louise Oakley, Barry Lavallee, Caroline Chartrand, Lorraine McLeod, Michelle Di Nella, Claudio Rigatto, Navdeep Tangri, Thomas Ferguson, Paul Komenda
Introduction: Rural and remote indigenous individuals have a high burden of chronic kidney disease (CKD) when compared to the general population. However, it has not been previously explored how these rates compare to urban-dwelling indigenous populations. Methods: In a recent cross-sectional screening study, 1346 adults 18 to 80 years of age were screened for CKD and diabetes across 11 communities in rural and remote areas in Manitoba, Canada, as part of the First Nations Community Based Screening to Improve Kidney Health and Prevent Dialysis (FINISHED) program...
July 2018: KI Reports
Kimberly A Muczynski, Nicolae Leca, Arthur E Anderson, Niamh Kieran, Susan K Anderson
Introduction: Current processing of renal biopsy samples provides limited information about immune mechanisms causing kidney injury and disease activity. We used flow cytometry with transplanted kidney biopsy samples to provide more information on the immune status of the kidney. Methods: To enhance the information available from a biopsy, we developed a technique for reducing a fraction of a renal biopsy sample to single cells for multicolor flow cytometry and quantitation of secreted cytokines present within the biopsy sample...
July 2018: KI Reports
C John Sperati, Chi Zhang, Marco Delsante, Rajib Gupta, Serena Bagnasco, Ishan Barman
No abstract text is available yet for this article.
July 2018: KI Reports
Meijian Guan, Jacob M Keaton, Latchezar Dimitrov, Pamela J Hicks, Jianzhao Xu, Nicholette D Palmer, James G Wilson, Barry I Freedman, Donald W Bowden, Maggie C Y Ng
Introduction: Compared with European Americans, African Americans (AAs) are at higher risk for developing end-stage kidney disease (ESKD). Genome-wide association studies (GWAS) have identified >70 genetic variants associated with kidney function and chronic kidney disease (CKD) in patients with and without diabetes. However, these variants explain a small proportion of disease liability. This study examined the contribution of coding genetic variants for risk of type 2 diabetes (T2D)-attributed ESKD and advanced CKD in AAs...
July 2018: KI Reports
Alexandra Cambier, Marion Rabant, Michel Peuchmaur, Alexandre Hertig, Georges Deschenes, Cecile Couchoud, Anne Kolko, Remi Salomon, Julien Hogan, Thomas Robert
Introduction: There is a need for treatment guidelines and prognostic factor identification in children with primary IgA nephropathy. We analyzed the causative effect of steroids and the applicability of the Oxford classification. Methods: A total of 82 consecutive children (mean 10.6 years; median follow-up 3.3 years) were reviewed; 21 patients (25.6%) presented with acute kidney injury, and 6 (7.3%) with nephrotic syndrome. Renal biopsies were scored for Oxford classification and podocytopathic features in 2 groups: a group treated with steroid therapy (some in association with cyclophosphamide) and supportive care (renin angiotensin system blockade) and a group treated by supportive care alone...
July 2018: KI Reports
Margaret Smith, William G Herrington, Misghina Weldegiorgis, Fd Richard Hobbs, Clare Bankhead, Mark Woodward
Introduction: Changes in urinary albumin-to-creatinine ratio (UACR) may affect the risk of advanced chronic kidney disease (CKD). How much the association changes after taking account for natural variation in UACR and the length of time taken to observe changes in UACR is unknown. Methods: English Clinical Practice Research Datalink records (2000-2015) with linkage to secondary care and death certification were used to identify prospective cohorts with at least 2 measures of UACR within 1, 2, and 3 years...
July 2018: KI Reports
Dominick Santoriello, Nanda K Pullela, Kalpana A Uday, Shawn Dhupar, Jai Radhakrishnan, Vivette D D'Agati, Glen S Markowitz
No abstract text is available yet for this article.
July 2018: KI Reports
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