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KI Reports

Kartik Ganesh, Rajesh R Nair, George Kurian, Anil Mathew, Sandeep Sreedharan, Zachariah Paul
No abstract text is available yet for this article.
March 2018: KI Reports
Karine Dahan, Valentine Gillion, Catherine Johanet, Hanna Debiec, Pierre Ronco
No abstract text is available yet for this article.
March 2018: KI Reports
Zeljko Dvanajscak, Bethany E Karl, Amber P Sanchez, Vighnesh Walavalkar
No abstract text is available yet for this article.
March 2018: KI Reports
Lena Berchtold, Gilbert Zanetta, Karine Dahan, Fabrice Mihout, Julie Peltier, Dominique Guerrot, Isabelle Brochériou, Pierre Ronco, Hanna Debiec
No abstract text is available yet for this article.
March 2018: KI Reports
Rahul Chanchlani, Paul Thorner, Seetha Radhakrishnan, Diane Hebert, Valerie Langlois, Steven Arora, David Barth, Daniel Cattran, Michael Kirschfink, Christoph Licht
No abstract text is available yet for this article.
March 2018: KI Reports
Laith Al-Rabadi, Karen Quillen, Moshe Shashar, Catreena Al Marji, Aala Jaberi, Vipul Chitalia, Joel Henderson, David Salant, Laurence H Beck
No abstract text is available yet for this article.
March 2018: KI Reports
Vijaya B Kolachalama, Priyamvada Singh, Christopher Q Lin, Dan Mun, Mostafa E Belghasem, Joel M Henderson, Jean M Francis, David J Salant, Vipul C Chitalia
Introduction: Chronic kidney damage is routinely assessed semiquantitatively by scoring the amount of fibrosis and tubular atrophy in a renal biopsy sample. Although image digitization and morphometric techniques can better quantify the extent of histologic damage, we need more widely applicable ways to stratify kidney disease severity. Methods: We leveraged a deep learning architecture to better associate patient-specific histologic images with clinical phenotypes (training classes) including chronic kidney disease (CKD) stage, serum creatinine, and nephrotic-range proteinuria at the time of biopsy, and 1-, 3-, and 5-year renal survival...
March 2018: KI Reports
Anitha Vijayan, Rowena B Delos Santos, Tingting Li, Charles W Goss, Paul M Palevsky
Introduction: The optimal frequency of intermittent hemodialysis (IHD) in the treatment of acute kidney injury (AKI) remains unclear. Increasing the frequency of IHD, while offering the possible advantage of reduced ultrafiltration requirement and less hemodynamic instability per session, amplifies patient contact with an extracorporeal circuit with possible deleterious cardiovascular and immunological consequences. A recent study suggested that intensive renal replacement therapy (RRT) is associated with a decrease in urine output during AKI...
March 2018: KI Reports
Ting-Yun Lin, Paik-Seong Lim, Szu-Chun Hung
Introduction: Unlike the general population, a higher body mass index (BMI) is associated with greater survival among patients with chronic kidney disease (CKD). This "obesity paradox" may be due to limitations of BMI as a measure of adiposity in CKD. Both BMI and body fat percentage (BF%) are used to classify obesity, but outcomes may vary. Therefore, we investigated the 2 different cutoffs for diagnosing obesity (BMI ≥28 kg/m2 or BF% >25% for men and >35% for women) and the impact on all-cause mortality in CKD...
March 2018: KI Reports
Debbie S Gipson, David T Selewski, Susan F Massengill, Mary Margaret Modes, Hailey Desmond, Lauren Lee, Elaine Kamil, Matthew R Elliott, Sharon G Adler, Gia Oh, Richard A Lafayette, Patrick E Gipson, Aditi Sinha, Arvind Bagga, Anne Pesenson, Cheryl Courtlandt, Cathie Spino, Richard Eikstadt, Renée Pitter, Samara Attalla, Anne Waldo, Richard Winneker, Noelle E Carlozzi, Jonathan P Troost, Irving Smokler, Mark Stone
Introduction: NephCure Accelerating Cures Institute (NACI) is a collaborative organization sponsored by NephCure Kidney International and the University of Michigan. The Institute is composed of 7 cores designed to improve treatment options and outcomes for patients with glomerular disease: Clinical Trials Network, Data Warehouse, Patient-Reported Outcomes (PRO) and Endpoints Consortium, Clinical Trials Consulting Team, Quality Initiatives, Education and Engagement, and Data Coordinating Center...
March 2018: KI Reports
Nicholas R Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J Lomax-Browne, Annette G Hansen, Michelle Willicombe, Charles D Pusey, H Terence Cook, Steffen Thiel, Matthew C Pickering
Introduction: IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury. Methods: To elucidate the contribution of the lectin pathway to IgAN, we measured the 11 plasma lectin pathway components in a well-characterized cohort of patients with IgAN. Results: M-ficolin, L-ficolin, mannan-binding lectin (MBL)-associated serine protease (MASP)-1 and MBL-associated protein (MAp) 19 were increased, whereas plasma MASP-3 levels were decreased in patients with IgAN compared with healthy controls...
March 2018: KI Reports
Alexander S Goldfarb-Rumyantzev, Shiva Gautam, Ning Dong, Robert S Brown
Introduction: Because chronic kidney disease (CKD) adversely affects survival, prediction of mortality risk should help to identify individuals requiring therapeutic intervention. The goal of this project was to construct and to validate a risk scoring system and prediction model of the probability of 2-year mortality in a CKD population. Methods: We applied the Woodpecker approach to develop prediction equations using linear, exponential, and combined models. A risk indicator R on a scale of 0 to 10 was calculated as follows: starting with 0, add 0...
March 2018: KI Reports
Dennis G Moledina, Bettina Cheung, Lidiya Kukova, Randy L Luciano, Aldo J Peixoto, F Perry Wilson, Sandra Alfano, Chirag R Parikh
Introduction: As part of the precision medicine initiative, the National Institutes of Health/National Institute of Diabetes and Digestive Kidney Diseases has proposed collecting human kidney tissue to discover novel therapeutic targets from patients with kidney diseases. Patient attitudes on participating in kidney biopsy-based research are largely unknown. Methods: We evaluated attitudes toward donating kidney tissue to research among participants who had experienced a clinically indicated kidney biopsy, through a survey conducted 9 months (interquartile range, 5-13 months) after their biopsy...
March 2018: KI Reports
Angela Pakozdi, Ravindra Rajakariar, Debasish Pyne, Andrea Cove-Smith, Muhammad Magdi Yaqoob
Introduction: Randomized controlled trials (RCTs) are considered the gold standard for assessing treatment efficacy. However, sampling bias can affect the generalization of results to routine clinical practice. Here we assessed whether patients with lupus nephritis (LN) seen in routine clinical practice would have satisfied entry criteria to the major published RCTs in LN. Methods: A systematic literature search from January 1974 to May 2015 was carried out, identifying all RCTs investigating LN induction treatment...
March 2018: KI Reports
Frank B Cortazar, Saif A Muhsin, William F Pendergraft, Zachary S Wallace, Colleen Dunbar, Karen Laliberte, John L Niles
Introduction: Remission induction in antineutrophil cytoplasmic autoantibody (ANCA) vasculitis may be complicated by slow response to treatment and toxicity from glucocorticoids. We describe outcomes with a novel remission induction regimen combining rituximab with a short course of low-dose, oral cyclophosphamide and an accelerated prednisone taper. Methods: Patients were included in this retrospective study if they had newly diagnosed or relapsing ANCA vasculitis with a Birmingham Vasculitis Activity Score for Wegener Granulomatosis (BVAS-WG) ≥3 and received a standardized remission induction regimen...
March 2018: KI Reports
Keith A Betts, J Michael Woolley, Fan Mu, Cheryl Xiang, Wenxi Tang, Eric Q Wu
Introduction: There are limited data on the cost of hyperkalemia. Methods: This retrospective analysis of the Truven MarketScan claims database assessed the economic burden of hyperkalemia among selected adult patients with hyperkalemia and matched controls. Results: A total of 39,626 cases (patients with hyperkalemia) were matched to 39,626 controls (patients without hyperkalemia) based on age, dialysis, chronic kidney disease (CKD) stage, heart failure, and renin-angiotensin aldosterone system inhibitor use...
March 2018: KI Reports
Angel L M de Francisco, Javier Varas, Rosa Ramos, Jose Ignacio Merello, Bernard Canaud, Stefano Stuard, Julio Pascual, Pedro Aljama
Introduction: Long-term inappropriate proton pump inhibitors use (PPIs) is a matter of concern because of the risks associated with their long-term use in older patients with chronic conditions. The risk of PPI treatment in hemodialysis patients remains unexplored. Methods: We assessed the relationship between the use of PPIs and the risk of death in hemodialysis patients throughout a retrospective multicenter propensity score-matched study. Information about demographic, hemodialysis treatment, laboratory data, and concomitant medication was obtained from the EuCliD database (Fresenius Medical Care)...
March 2018: KI Reports
Masaaki Nakayama, Yoshihiro Tani, Wan-Jun Zhu, Kimio Watanabe, Keitaro Yokoyama, Masafumi Fukagawa, Takashi Akiba, Myles Wolf, Hideki Hirakata
Introduction: A recent study suggested that orally dosed ferric citrate hydrate (FC) corrects renal anemia in patients on hemodialysis (HD), suggesting biological differences in effects of iron supplementation using different routes of administration. To address this issue, the present study compared oral FC with i.v. saccharated ferric oxide (FO) in stable HD patients. Methods: Participants comprised 6 patients administered 3 consecutive protocols in the first HD session of the week in a fasting state: nothing given, as control (C); oral load of FC (480 mg iron), and 5 minutes of i...
March 2018: KI Reports
Shintaro Mandai, Hidehiko Sato, Soichiro Iimori, Shotaro Naito, Takayasu Mori, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai
Introduction: Accumulating evidence suggests that a large hospital volume (HV) is associated with favorable outcomes in various diseases or surgical procedures. The aim of this study is to clarify the correlation of HV and dialysis case volume (DCV) with in-hospital death in patients on maintenance dialysis. Methods: The study cohort was derived from the Diagnosis Procedure Combination database, a national inpatient database in Japan, from 2012 to 2014. We included 382,689 admissions of maintenance dialysis patients over the age of 20 years in the analysis...
March 2018: KI Reports
Anna T Mathew, Lisa Rosen, Renee Pekmezaris, Andrzej Kozikowski, Daniel W Ross, Thomas McGinn, Kamyar Kalantar-Zadeh, Steven Fishbane
Introduction: Patients with end-stage kidney disease have a high risk of 30-day readmission to hospital. These readmissions are financially costly to health care systems and are associated with poor health-related quality of life. The objective of this study was to describe and analyze the frequency, causes, and predictors of 30-day potentially avoidable readmission to hospital in patients on hemodialysis. Methods: We conducted a retrospective cohort study using the US Renal Data System data from January 1, 2008, to December 31, 2008...
March 2018: KI Reports
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