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KI Reports

Shakuntala Patil, Swathi Subramany, Sachin Patil, Pooja Gurram, Manisha Singh, Michelle Krause
No abstract text is available yet for this article.
September 2018: KI Reports
Blaise Abramovitz, Amanda Leonberg-Yoo, Jehan Z Bahrainwala, Harold Litt, Michael R Rudnick
No abstract text is available yet for this article.
September 2018: KI Reports
Wim Lemahieu, Sara Ombelet, Evelyne Lerut, Sofie Jamar, Ben Sprangers
No abstract text is available yet for this article.
September 2018: KI Reports
Monica S Y Ng, Kelly McClymont, Naomi McCallum, Rahul Dua, Katherine Holman, Bruce Bennetts, Gladys Ho, Chirag Patel, Andrew J Mallett
No abstract text is available yet for this article.
September 2018: KI Reports
Gregory J Wilson, Pedro H F Gois, Alice Zhang, Xiangju Wang, Becker M P Law, Andrew J Kassianos, Helen G Healy
No abstract text is available yet for this article.
September 2018: KI Reports
Melanie Aldridge, Chirag Patel, Andrew Mallett, Peter Trnka
No abstract text is available yet for this article.
September 2018: KI Reports
Li-Rong Yu, Jinchun Sun, Jaclyn R Daniels, Zhijun Cao, Laura Schnackenberg, Devasmita Choudhury, Paul M Palevsky, Jennie Z Ma, Richard D Beger, Didier Portilla
Introduction: Currently, no effective therapies exist to reduce the high mortality associated with dialysis-dependent acute kidney injury (AKI-D). Serum biomarkers may be useful in understanding the pathophysiological processes involved with AKI and the severity of injury, and point to novel therapeutic targets. Methods: Study day 1 serum samples from 100 patients and day 8 samples from 107 patients enrolled in the Veteran's Affairs/National Institutes of Health Acute Renal Failure Trial Network study were analyzed by the slow off-rate modified aptamers scan proteomic platform to profile 1305 proteins in each sample...
September 2018: KI Reports
Sanjeev Sethi, Surendra Dasari, Emmanuelle Plaisier, Pierre Ronco, Samih H Nasr, Isabelle Brocheriou, Jason D Theis, Julie A Vrana, Michael T Zimmermann, Patrick S Quint, Ellen D McPhail, Paul J Kurtin
Introduction: Apolipoprotein CII amyloidosis (AApoCII) is a rare form of amyloidosis. Here, we report a novel mutation associated with AApoCII amyloidosis in 5 patients and describe their clinical, renal biopsy, and mass spectrometry findings. Methods: Five patients with renal AApoCII p.Lys41Thr amyloidosis were identified from our amyloid mass spectrometry cohort. Clinical features, kidney biopsy, and mass spectrometry findings were analyzed in this rare type of amyloidosis...
September 2018: KI Reports
Ruth F Dubin, Suzanne Judd, Rebecca Scherzer, Michael Shlipak, David G Warnock, Mary Cushman, Mark Sarnak, Chirag Parikh, Michael Bennett, Neil Powe, Carmen A Peralta
Introduction: Urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury. In persons with reduced estimated glomerular filtration rate (eGFR) and albuminuria who are at high risk for end-stage renal disease (ESRD) and death, the associations of these urinary markers with incident ESRD or death is an area of active investigation. Methods: Among 1472 black and white participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study with eGFR ≤60 ml/min per 1...
September 2018: KI Reports
Rafael Valdez-Ortiz, Francisco Navarro-Reynoso, Ma Guadalupe Olvera-Soto, Geovana Martin-Alemañy, Adrian Rodríguez-Matías, Clara Rocío Hernández-Arciniega, Mario Cortes-Pérez, Ernesto Chávez-López, Gloria García-Villalobos, Héctor Hinojosa-Heredia, Ana Yetzin Camacho-Aguirre, Ángel Valdez-Ortiz, Guillermo Cantú-Quintanilla, Irma Gómez-Guerrero, Arturo Reding, Monserrat Pérez-Navarro, Gregorio Obrador, Ricardo Correa-Rotter
Introduction: Despite a systematic increase in the coverage of patients with end-stage renal disease (ESRD) who have received dialytic therapies and transplantation over the past 2 decades, the Mexican health system currently still does not have a program to provide full coverage of ESRD. Our aim was to analyze mortality in patients with ESRD without health insurance. Methods: This was a prospective cohort study of 850 patients with advanced chronic kidney disease (CKD)...
September 2018: KI Reports
Silvia B González, Guillermo Menga, Guillermo A Raimondi, Hocine Tighiouart, Horacio J Adrogué, Nicolaos E Madias
Introduction: The magnitude of the secondary response to chronic respiratory acidosis, that is, change in plasma bicarbonate concentration ([HCO3 - ]) per mm Hg change in arterial carbon dioxide tension (PaCO2 ), remains uncertain. Retrospective observations yielded Δ[HCO3 - ]/ΔPaCO2 slopes of 0.35 to 0.51 mEq/l per mm Hg, but all studies have methodologic flaws. Methods: We studied prospectively 28 stable outpatients with steady-state chronic hypercapnia. Patients did not have other disorders and were not taking medications that could affect acid-base status...
September 2018: KI Reports
Mathilde Lemoine, Arnaud François, Steven Grangé, Marion Rabant, Valérie Châtelet, David Cassiman, Emilie Cornec-Le Gall, Damien Ambrosetti, Georges Deschênes, Jean-François Benoist, Dominique Guerrot
Introduction: Cobalamin C (cblC) deficiency is the most common inborn error of vitamin B12 metabolism. Renal failure attributed to thrombotic microangiopathy (TMA) has occasionally been described in the late-onset presentation of cblC deficiency, but kidney lesions associated with cblC deficiency remain poorly defined. This study aims to describe the characteristics of kidney disease in cblC deficiency, and to provide a comparative histological analysis with cblC-independent renal TMA...
September 2018: KI Reports
Malte Kölling, Harald Seeger, George Haddad, Andreas Kistler, Albina Nowak, Robert Faulhaber-Walter, Jan Kielstein, Hermann Haller, Danilo Fliser, Thomas Mueller, Rudolf P Wüthrich, Johan M Lorenzen
Introduction: Circular RNAs (circRNAs) have recently been described as novel noncoding regulators of gene expression. They might have an impact on microRNA expression by their sponging activity. The detectability in blood of these RNA transcripts has been demonstrated in patients with cancer and cardiovascular disease. We tested the hypothesis that circulating circRNAs in blood of critically ill patients with acute kidney injury (AKI) at inception of renal replacement therapy may also be dysregulated and associated with patient survival...
September 2018: KI Reports
Fang Wang, Kevin He, Jinwei Wang, Ming-Hui Zhao, Yi Li, Luxia Zhang, Rajiv Saran, Jennifer L Bragg-Gresham
Introduction: Chronic kidney disease (CKD) is an important noncommunicable disease globally. Overall prevalence of CKD and distribution of its stages differ between countries. We postulate that these differences may not only be due to variation in prevalence of risk factors but also their differential impact in different populations or settings. Methods: We used nationally representative data on the adult populations from both the United States (US; National Health and Nutrition Examination Survey [NHANES], 2009 to 2010, N = 5557) and China (China National Survey of CKD, 2009 to 2010, N = 46,949)...
September 2018: KI Reports
Mazdak A Khalighi, Laith Al-Rabadi, Meghana Chalasani, Mark Smith, Siddhartha Kakani, Monica P Revelo, Shane M Meehan
Introduction: Staphylococcal infection-related glomerulonephritis (GN) has been shown to represent a unique form of infection-related GN that contains IgA-dominant deposits and is often seen concurrently with the bacterial infection. Biopsies commonly reveal an endocapillary proliferative and/or exudative or mesangial proliferative GN. Rare cases have been reported to show cryoglobulin-like features, including hyaline pseudothrombi and wireloop deposits; however, detailed characterization of these cases is lacking...
September 2018: KI Reports
Brian L K Miller, Payal Garg, Ben Bronstein, Elizabeth LaPointe, Herb Lin, David M Charytan, Arno W Tilles, Biju Parekkadan
Introduction: The pathophysiology of acute kidney injury (AKI) involves damage to renal epithelial cells, podocytes, and vascular beds that manifests into a deranged, self-perpetuating immune response and peripheral organ dysfunction. Such an injury pattern requires a multifaceted therapeutic to alter the wound healing response systemically. Mesenchymal stromal cells (MSCs) are a unique source of secreted factors that can modulate an inflammatory response to acute organ injury and enhance the repair of injured tissue at the parenchymal and endothelial levels...
September 2018: KI Reports
Vinay Kumar, Suraj Hebbar, Ananthram Bhat, Sachin Panwar, Madhumati Vaishnav, Kavitha Muniraj, Vasanthi Nath, Reshma Banaki Vijay, Sapna Manjunath, Babithadevi Thyagaraj, Chandraprabha Siddalingappa, Muralidharakrishna Chikkamoga Siddaiah, Indranil Dasgupta, Urmila Anandh, Thummala Kamala, S S Srikanta, P R Krishnaswamy, Navakanta Bhat
Introduction: Early detection of diabetes mellitus (DM) and diabetic kidney disease (DKD) is important for preventing end-stage renal failure and reducing cardiovascular complications. Availability of a validated point-of-care (PoC) device that can measure various DKD markers would be useful in this respect, especially in resource-poor parts of the world. Methods: We validated a novel nanotechnology-based multianalyte PoC device (minimally invasive and does not require trained medical personnel) against laboratory gold standard tests for the detection of 5 biomarkers related to management of DM and DKD...
September 2018: KI Reports
Claudia Torino, Patrizia Pizzini, Sebastiano Cutrupi, Maurizio Postorino, Giovanni Tripepi, Francesca Mallamaci, Jochen Reiser, Carmine Zoccali
Introduction: The soluble receptor of urokinase plasminogen activator (suPAR) is an innate immunity/inflammation biomarker predicting cardiovascular (CV) and non-CV events in various conditions, including type 2 diabetic patients on dialysis. However, the relationship between suPAR and clinical outcomes in the hemodialysis population at large has not been tested. Methods: We measured plasma suPAR levels (R&D enzyme-linked immunosorbent assay [ELISA]) in 1038 hemodialysis patients with a follow-up of 2...
September 2018: KI Reports
Yassine Bouatou, Angele Gayet Ageron, Enos Bernasconi, Manuel Battegay, Matthias Hoffmann, Cornelia Staehelin, Laurent Merz, Helen Kovari, Christoph Fux, Sophie de Seigneux, Alexandra Calmy
Introduction: Antiretroviral therapy has improved the life expectancy of patients living with HIV. However, lipodystrophy syndrome (LD) remains prevalent, affecting mostly patients treated with first-generation antiretroviral drugs. This syndrome is characterized by changes in body fat distribution with or without associated metabolic changes. Here, we studied whether clinically evaluated LD is independently associated with chronic kidney disease (CKD) development (sustained estimated glomerular filtration rate [eGFR] < 60 ml/min per 1...
September 2018: KI Reports
Claudio Luders, Silvia Maria Titan, Soubhi Kahhale, Rossana Pulcineli Francisco, Marcelo Zugaib
Introduction: Pregnancy in women on dialysis is associated with a higher risk of adverse events, and the best care for this population remains to be established. Methods: In this series, we aimed to identify factors associated with the risk of adverse fetal outcomes among 93 pregnancies in women on hemodialysis. Dialysis dose was initially assigned according to the presence of residual diuresis, body weight, and years on dialysis. Subsequent adjustments on dialysis dose were performed according to several parameters...
September 2018: KI Reports
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