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Lancet. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/30573391/driving-in-the-dark-cirrhosis-in-young-adults
#1
Ghideon Ezaz, Elliot B Tapper
No abstract text is available yet for this article.
December 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30573390/incidence-of-cirrhosis-in-young-birth-cohorts-in-canada-from-1997-to-2016-a-retrospective-population-based-study
#2
Jennifer A Flemming, Yvonne Dewit, Jeffrey M Mah, James Saperia, Patti A Groome, Christopher M Booth
BACKGROUND: Recent data show that the prevalence of chronic liver disease and cirrhosis is increasing in adolescents and young adults in the USA. We aimed to describe the epidemiology of cirrhosis using an age-period-cohort approach to define birth-cohort effects on the incidence of cirrhosis in Ontario, Canada. METHODS: We did a retrospective population-based cohort study in Ontario, Canada, using linked administrative health data from the databases of ICES, formerly the Institute for Clinical Evaluative Sciences...
December 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30555049/effective-drugs-on-the-road-to-hcv-elimination-and-a-therapeutic-gap-to-close
#3
David H Muljono
No abstract text is available yet for this article.
December 13, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30555048/sofosbuvir-velpatasvir-for-treatment-of-chronic-hepatitis-c-virus-infection-in-asia-a-single-arm-open-label-phase-3-trial
#4
Lai Wei, Seng Gee Lim, Qing Xie, Kính Nguyen Văn, Teerha Piratvisuth, Yan Huang, Shanming Wu, Ming Xu, Hong Tang, Jun Cheng, Hung Le Manh, Yanhang Gao, Zhuangbo Mou, Abhasnee Sobhonslidsuk, Xiaguang Dou, Satawat Thongsawat, Yuemin Nan, Chee Kiat Tan, Qin Ning, Hoi Poh Tee, Yimin Mao, Luisa M Stamm, Sophia Lu, Hadas Dvory-Sobol, Hongmei Mo, Diana M Brainard, Yong-Feng Yang, Long Dao, Gui-Qiang Wang, Tawesak Tanwandee, Peng Hu, Pisit Tangkijvanich, Lunli Zhang, Zhi Liang Gao, Feng Lin, Thi Tuyet Phuong Le, Jia Shang, Guozhong Gong, Jun Li, Minghua Su, Zhongping Duan, Rosmawati Mohamed, Jin Lin Hou, Jidong Jia
BACKGROUND: Treatment with combined sofosbuvir and velpatasvir has resulted in high sustained virological response rates in patients chronically infected with hepatitis C virus (HCV) with genotypes 1-6 in clinical trials and real-world settings, but its efficacy and safety has not been assessed in Asia, a region with diverse HCV genotypes. METHODS: In this single-arm, open-label, phase 3 trial, we recruited patients from 38 sites across China, Thailand, Vietnam, Singapore, and Malaysia, who were chronically infected with HCV genotypes 1-6, and were HCV treatment-naive or treatment-experienced, either without cirrhosis or with compensated cirrhosis...
December 13, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30552057/direct-acting-antiviral-therapy-in-sub-saharan-africa
#5
C Wendy Spearman, Mark W Sonderup
No abstract text is available yet for this article.
December 10, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30552056/treatment-of-chronic-hepatitis-c-virus-infection-in-rwanda-with-ledipasvir-sofosbuvir-shared-a-single-arm-trial
#6
Neil Gupta, Aimable Mbituyumuremyi, Jules Kabahizi, Fabien Ntaganda, Claude Mambo Muvunyi, Fabienne Shumbusho, Emmanuel Musabeyezu, Constance Mukabatsinda, Cyprien Ntirenganya, Jennifer Ilo Van Nuil, Fredrick Kateera, Gregory Camus, Makuza Jean Damascene, Sabin Nsanzimana, Joia Mukherjee, Philip M Grant
BACKGROUND: Limited treatment data are available for hepatitis C virus (HCV) in sub-Saharan Africa, especially for genotype 4. Our objective was to establish the safety and efficacy of ledipasvir-sofosbuvir for chronic HCV genotype 1 or 4 infection in adults in Rwanda. METHODS: We did a single-arm trial to evaluate the safety and efficacy of ledipasvir-sofosbuvir in Rwandan adults with chronic HCV infection at a single study site (Rwanda Military Hospital, Kigali, Rwanda)...
December 10, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30502933/effect-of-flexible-sigmoidoscopy-screening-on-colorectal-cancer-incidence-and-mortality-long-term-follow-up-of-the-randomised-us-plco-cancer-screening-trial
#7
Eric A Miller, Paul F Pinsky, Robert E Schoen, Philip C Prorok, Timothy R Church
BACKGROUND: Screening flexible sigmoidoscopy reduces incidence and mortality of colorectal cancer. Previously reported results from the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) screening trial had a median follow-up of 12 years. Whether the benefit is sustained over the long term and remains so in both sexes and all age groups is uncertain. We report long-term results after an additional 5 years of follow-up. METHODS: Participants in the PLCO trial were recruited from the general population in the catchment areas of ten screening centres across the USA, without previous diagnosis of a prostate, lung, colorectal, or ovarian cancer or current cancer treatment...
November 28, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30502932/sigmoidoscopy-a-shortcut-to-effective-screening-or-a-dead-end
#8
Marek Bugajski, Michal F Kaminski
No abstract text is available yet for this article.
November 28, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30497963/faecal-immunochemical-tests-when-quantitation-is-not-enough
#9
Stephen P Halloran
No abstract text is available yet for this article.
November 26, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30497962/performance-of-two-faecal-immunochemical-tests-for-the-detection-of-advanced-neoplasia-at-different-positivity-thresholds-a-cross-sectional-study-of-the-dutch-national-colorectal-cancer-screening-programme
#10
Clasine M de Klerk, Els Wieten, Iris Lansdorp-Vogelaar, Patrick M Bossuyt, Manon Cw Spaander, Evelien Dekker
BACKGROUND: Faecal immunochemical tests (FITs) are recommended for colorectal cancer screening. Two frequently used FIT methods (FOB-Gold, Sentinel Diagnostics, Milan, Italy and OC-Sensor, Eiken Chemical, Tokyo, Japan) perform similarly in detecting advanced neoplasia (ie, colorectal cancer and advanced adenoma) at a fixed positivity cutoff for faecal haemoglobin concentration. It is unclear whether the performance of the two methods is also comparable at other thresholds. We compared the accuracy of the two assays in detecting advanced neoplasia across various thresholds...
November 26, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30477810/case-finding-and-therapy-for-chronic-viral-hepatitis-in-primary-care-hepfree-a-cluster-randomised-controlled-trial
#11
Stuart Flanagan, Jan Kunkel, Victoria Appleby, Sandra E Eldridge, Sharif Ismail, Sulleman Moreea, Christopher Griffiths, Robert Walton, Martin Pitt, Andrew Salmon, Vicithranie Madurasinghe, Eleanor Barnes, Elizabeth Simms, Kosh Agarwal, Graham R Foster
BACKGROUND: The prevalence of viral hepatitis (hepatitis B virus and hepatitis C virus) in migrants is higher than among the general population in many high-income countries. We aimed to determine whether incentivising and supporting primary-care physicians in areas with a high density of migrants increases the numbers of adult migrants screened for viral hepatitis. METHODS: HepFREE was a multicentre, open, cluster-randomised controlled trial in general practices in areas of the UK with a high density of migrants (Bradford, Yorkshire, and northeast and southeast London)...
November 23, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30477809/hepatitis-case-finding-among-migrants-in-primary-care
#12
Matthew Hickman, Sema Mandel, Peter Vickerman, Alec Miners, Natasha Martin
No abstract text is available yet for this article.
November 23, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30473202/efficacy-of-individual-and-group-hypnotherapy-in-irritable-bowel-syndrome-imagine-a-multicentre-randomised-controlled-trial
#13
Carla E Flik, Wijnand Laan, Nicolaas P A Zuithoff, Yanda R van Rood, André J P M Smout, Bas L A M Weusten, Peter J Whorwell, Niek J de Wit
BACKGROUND: Hypnotherapy for irritable bowel syndrome (IBS) has been used primarily in patients with refractory symptoms in specialised departments and delivered on an individual basis. We aimed to test the hypothesis that hypnotherapy would be more effective than educational supportive therapy, and that group hypnotherapy would be non-inferior to individual hypnotherapy for patients with IBS referred from primary and secondary care. METHODS: We did a multicentre randomised controlled trial (IMAGINE) in 11 hospitals in the Netherlands...
November 22, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30473201/is-hypnotherapy-helpful-for-irritable-bowel-syndrome-in-primary-and-secondary-care
#14
Olafur S Palsson
No abstract text is available yet for this article.
November 22, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30472052/unmet-needs-in-end-of-life-care-for-chronic-liver-disease
#15
Tom Thomas, Joht Singh Chandan, Neeraj Bhala
No abstract text is available yet for this article.
November 21, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30472051/place-of-death-and-factors-associated-with-hospital-death-in-patients-who-have-died-from-liver-disease-in-england-a-national-population-based-study
#16
Jen-Kuei Peng, Irene J Higginson, Wei Gao
BACKGROUND: Liver disease is a major cause of mortality, with high numbers of hospital deaths, and disproportionately affects people younger than 65 years. This study aims to examine the place of death and factors associated with hospital death for people who died from liver disease. METHOD: We did a national population-based, observational study using the National Death Registration Database from the Office for National Statistics, 2001-14. All non-accidental adult deaths (hospital and non-hospital) from liver disease in England were included...
November 21, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30393106/efficacy-and-safety-of-glecaprevir-pibrentasvir-in-patients-with-chronic-hepatitis-c-virus-genotype-5-or-6-infection-endurance-5-6-an-open-label-multicentre-phase-3b-trial
#17
Tarik Asselah, Samuel S Lee, Betty B Yao, Tuan Nguyen, Florence Wong, Adam Mahomed, Seng Gee Lim, Armand Abergel, Joe Sasadeusz, Edward Gane, Neddie Zadeikis, Gretja Schnell, Zhenzhen Zhang, Ariel Porcalla, Federico J Mensa, Kinh Nguyen
BACKGROUND: The pangenotypic direct-acting antiviral regimen of glecaprevir coformulated with pibrentasvir is approved to treat chronic hepatitis C virus (HCV) genotype 1-6 infection in adults. In registrational studies, 84 (99%) of 85 patients with HCV genotype 5 or 6 infection achieved a sustained virological response (SVR) with glecaprevir/pibrentasvir, with no virological failures. To increase the body of data for these less prevalent genotypes, ENDURANCE-5,6 evaluated the efficacy and safety of glecaprevir/pibrentasvir exclusively in patients infected with HCV genotype 5 or 6...
November 1, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30385103/ueg-week-2018
#18
Rob Brierley
No abstract text is available yet for this article.
October 29, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30361079/imipramine-for-functional-dyspepsia-a-60-year-journey
#19
Takeshi Kanno, Paul Moayyedi
No abstract text is available yet for this article.
October 22, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30647022/correction-to-lancet-gastroenterol-hepatol-2018-3-825-36
#20
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Lancet. Gastroenterology & Hepatology
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