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Lancet. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/30017647/ensuring-timely-treatment-of-patients-with-primary-biliary-cholangitis
#1
Hanns-Ulrich Marschall
No abstract text is available yet for this article.
July 12, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30017646/pretreatment-prediction-of-response-to-ursodeoxycholic-acid-in-primary-biliary-cholangitis-development-and-validation-of-the-udca-response-score
#2
Marco Carbone, Alessandra Nardi, Steve Flack, Guido Carpino, Nikoletta Varvaropoulou, Caius Gavrila, Ann Spicer, Jonathan Badrock, Francesca Bernuzzi, Vincenzo Cardinale, Holly F Ainsworth, Michael A Heneghan, Douglas Thorburn, Andrew Bathgate, Rebecca Jones, James M Neuberger, Pier Maria Battezzati, Massimo Zuin, Simon Taylor-Robinson, Maria F Donato, John Kirby, Robert Mitchell-Thain, Annarosa Floreani, Fotios Sampaziotis, Luigi Muratori, Domenico Alvaro, Marco Marzioni, Luca Miele, Fabio Marra, Edoardo Giannini, Eugenio Gaudio, Vincenzo Ronca, Giulia Bonato, Laura Cristoferi, Federica Malinverno, Alessio Gerussi, Deborah D Stocken, Heather J Cordell, Gideon M Hirschfield, Graeme J Alexander, Richard N Sandford, David E Jones, Pietro Invernizzi, George F Mells
BACKGROUND: Treatment guidelines recommend a stepwise approach to primary biliary cholangitis: all patients begin treatment with ursodeoxycholic acid (UDCA) monotherapy and those with an inadequate biochemical response after 12 months are subsequently considered for second-line therapies. However, as a result, patients at the highest risk can wait the longest for effective treatment. We determined whether UDCA response can be accurately predicted using pretreatment clinical parameters...
July 12, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29983372/non-invasive-diagnosis-of-liver-fibrosis-in-patients-with-alcohol-related-liver-disease-by-transient-elastography-an-individual-patient-data-meta-analysis
#3
Eric Nguyen-Khac, Maja Thiele, Cosmin Voican, Pierre Nahon, Christophe Moreno, Jerome Boursier, Sebastian Mueller, Victor de Ledinghen, Peter Stärkel, Sang Gyune Kim, Michael Fernandez, Bjorn Madsen, Sylvie Naveau, Aleksander Krag, Gabriel Perlemuter, Marianne Ziol, Denis Chatelain, Momar Diouf
BACKGROUND: The value of transient elastography for the non-invasive diagnosis of alcohol-related liver fibrosis is subject to debate. We did an individual patient data (IPD) meta-analysis to determine specific diagnostic cutoff values for liver stiffness in alcohol-related fibrosis, and to assess the effect of aminotransferase concentrations, bilirubin concentrations, and presence of asymptomatic and non-severe alcoholic hepatitis on liver stiffness. METHODS: We searched for studies that included patients with alcohol-related liver disease, liver biopsy, and transient elastography, and with a statistical method for determining the diagnostic cutoffs for alcohol-induced liver fibrosis on the basis of the FibroScan results, in PubMed between Jan 1, 2000, and Sept 30, 2017...
July 5, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29983371/transient-elastography-for-alcoholic-liver-disease-a-step-forward
#4
Elisa Pose, Pere Ginès
No abstract text is available yet for this article.
July 5, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29934225/a-simpler-way-to-do-radiofrequency-ablation-for-barrett-s-oesophagus
#5
Charles J Lightdale
No abstract text is available yet for this article.
June 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29934224/simplified-versus-standard-regimen-for-focal-radiofrequency-ablation-of-dysplastic-barrett-s-oesophagus-a-multicentre-randomised-controlled-trial
#6
Roos E Pouw, Hannah T Künzli, Raf Bisschops, Carine M Sondermeijer, Arjun D Koch, Paul Didden, Anniek W Gotink, Erik J Schoon, Wouter L Curvers, Jacques J G H M Bergman, Bas L A M Weusten
BACKGROUND: For focal radiofrequency ablation of Barrett's oesophagus, a simplified regimen (3 × 15 J/cm2 , without cleaning) has proven to be as effective as the standard regimen (2 × 15 J/cm2 , followed by cleaning, followed by 2 × 15 J/cm2 ). However, this simplified regimen seemed to be associated with a higher stenosis rate. Therefore, we lowered the radiofrequency energy and hypothesised that this new simplified regimen would be as effective and safe as the standard regimen...
June 19, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29914844/an-optimal-metric-for-imaging-in-small-bowel-crohn-s-disease
#7
Isabelle De Kock, Louke Delrue, Pieter Hindryckx
No abstract text is available yet for this article.
June 15, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29914843/diagnostic-accuracy-of-magnetic-resonance-enterography-and-small-bowel-ultrasound-for-the-extent-and-activity-of-newly-diagnosed-and-relapsed-crohn-s-disease-metric-a-multicentre-trial
#8
Stuart A Taylor, Susan Mallett, Gauraang Bhatnagar, Rachel Baldwin-Cleland, Stuart Bloom, Arun Gupta, Peter J Hamlin, Ailsa L Hart, Antony Higginson, Ilan Jacobs, Sara McCartney, Anne Miles, Charles D Murray, Andrew A Plumb, Richard C Pollok, Shonit Punwani, Laura Quinn, Manuel Rodriguez-Justo, Zainib Shabir, Andrew Slater, Damian Tolan, Simon Travis, Alastair Windsor, Peter Wylie, Ian Zealley, Steve Halligan
BACKGROUND: Magnetic resonance enterography (MRE) and ultrasound are used to image Crohn's disease, but their comparative accuracy for assessing disease extent and activity is not known with certainty. Therefore, we did a multicentre trial to address this issue. METHODS: We recruited patients from eight UK hospitals. Eligible patients were 16 years or older, with newly diagnosed Crohn's disease or with established disease and suspected relapse. Consecutive patients had MRE and ultrasound in addition to standard investigations...
June 15, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29908782/digestive-disease-week-2018
#9
Jennifer Thorley, Rob Brierley
No abstract text is available yet for this article.
June 13, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29859740/deferred-treatment-with-sofosbuvir-velpatasvir-voxilaprevir-for-patients-with-chronic-hepatitis-c-virus-who-were-previously-treated-with-an-ns5a-inhibitor-an-open-label-substudy-of-polaris-1
#10
Marc Bourlière, Stuart C Gordon, Eugene R Schiff, Tram T Tran, Natarajan Ravendhran, Charles S Landis, Robert H Hyland, Luisa M Stamm, Jie Zhang, Hadas Dvory-Sobol, G Mani Subramanian, Diana M Brainard, John G McHutchison, Lawrence Serfaty, Alex J Thompson, Thomas E Sepe, Michael P Curry, K Rajender Reddy, Michael P Manns
BACKGROUND: Direct-acting antiviral regimens containing NS5A inhibitors are highly effective treatments for chronic hepatitis C virus (HCV) infection, but are not always successful. In the POLARIS-1 phase 3 study, sofosbuvir-velpatasvir-voxilaprevir for 12 weeks was highly effective in the treatment of chronic HCV infection in patients previously treated with a direct-acting antiviral regimen containing an NS5A inhibitor. We aimed to assess the efficacy and safety of sofosbuvir-velpatasvir-voxilaprevir in patients from the deferred treatment group of POLARIS-1, who were initially assigned to masked placebo treatment...
May 30, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29859739/retreatment-of-hepatitis-c-virus-can-it-get-any-better
#11
Imam Waked
No abstract text is available yet for this article.
May 30, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29805117/treating-constipation-with-bile-a-new-target
#12
Satish S C Rao
No abstract text is available yet for this article.
May 24, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29805116/safety-and-efficacy-of-elobixibat-for-chronic-constipation-results-from-a-randomised-double-blind-placebo-controlled-phase-3-trial-and-an-open-label-single-arm-phase-3-trial
#13
Atsushi Nakajima, Mitsunori Seki, Shinya Taniguchi, Akira Ohta, Per-Göran Gillberg, Jan P Mattsson, Michael Camilleri
BACKGROUND: A subset of patients with constipation has reduced colonic bile acid concentrations, which are associated with slow colonic transit. In a previous study, elobixibat, a locally acting ileal bile acid transporter inhibitor, accelerated colonic transit in Japanese patients with functional constipation. In this study, we aimed to determine the efficacy of elobixibat for short-term treatment of chronic constipation, and safety, patient satisfaction, and quality of life with long-term treatment...
May 24, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893236/gastrointestinal-tract-involvement-in-klippel-tr%C3%A3-naunay-syndrome
#14
Andrea Sepulveda, Humberto Soriano, Alberto Espino
No abstract text is available yet for this article.
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893235/non-alcoholic-fatty-liver-disease-and-the-interface-between-primary-and-secondary-care
#15
REVIEW
Emmanuel A Tsochatzis, Philip N Newsome
Non-alcoholic fatty liver disease (NAFLD) has a prevalence of 25-30% in unselected populations and has become the main reason for referrals to hepatology services. From the perspective of liver disease, NAFLD has a high prevalence but low severity. Screening studies in people at risk for NAFLD have shown a prevalence of advanced fibrosis of 5%, which underlines the need for robust pathways for risk stratification in primary care, with subsequent referrals as required. In this Review, we discuss the interface between primary and secondary care with regards to risk stratification and management of patients with NAFLD...
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893234/safely-reprocessing-duodenoscopes-current-evidence-and-future-directions
#16
REVIEW
Zachary A Rubin, Stephen Kim, Adarsh M Thaker, V Raman Muthusamy
Highly publicised outbreaks of various infections related to the use of duodenoscopes have increased public awareness of the once arcane and largely ignored subject of endoscope reprocessing. Since 2015, national professional societies, multiple federal agencies, and even the US Senate have written reports and guidelines on duodenoscope reprocessing. However, their recommendations are sometimes contradictory and difficult to implement, and new research on the topic is published regularly which further complicates the situation...
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893233/food-for-thought-the-angry-chef
#17
Paul Kiet Tang
No abstract text is available yet for this article.
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893232/ren%C3%A3-laennec-no-going-back
#18
Talha Khan Burki
No abstract text is available yet for this article.
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893231/enteral-nutrition-during-major-surgery-how-to-proceed-after-sanics-ii-authors-reply
#19
LETTER
Misha D P Luyer
No abstract text is available yet for this article.
July 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29893230/enteral-nutrition-during-major-surgery-how-to-proceed-after-sanics-ii
#20
LETTER
Matthijs Plas, Barbara L van Leeuwen, Jacco J de Haan
No abstract text is available yet for this article.
July 2018: Lancet. Gastroenterology & Hepatology
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