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Lancet. Gastroenterology & Hepatology

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https://www.readbyqxmd.com/read/30245064/direct-acting-antiviral-treatment-for-hepatitis-c-among-people-who-use-or-inject-drugs-a-systematic-review-and-meta-analysis
#1
Behzad Hajarizadeh, Evan B Cunningham, Hannah Reid, Matthew Law, Gregory J Dore, Jason Grebely
BACKGROUND: There are concerns around poorer response to direct-acting antiviral (DAA) therapy for hepatitis C virus infection among people who use drugs. This systematic review assessed DAA treatment outcomes among people with recent drug use and those receiving opioid substitution therapy. METHODS: Bibliographic databases and conference presentations were searched for observational studies and clinical trials assessing DAA treatment completion, sustained virological response (SVR), and loss to follow-up among people with recent drug use (injecting or non-injecting) and those receiving opioid substitution therapy...
September 20, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30245063/hcv-treatment-for-people-with-recent-drug-use-time-for-new-measures-of-success
#2
Anne Øvrehus, Martin Kåberg
No abstract text is available yet for this article.
September 20, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30236904/home-based-versus-office-based-biofeedback-therapy-for-constipation-with-dyssynergic-defecation-a-randomised-controlled-trial
#3
Satish S C Rao, Jessica A Valestin, Xuelian Xiang, Shaheen Hamdy, Catherine S Bradley, M Bridget Zimmerman
BACKGROUND: Office-based biofeedback therapy is effective for constipation with dyssynergic defecation, but must be performed by skilled staff, is only available in selected centres, and requires multiple visits. The efficacy of home-based biofeedback therapy is unknown. We compared clinical and subjective outcomes with home-based and office-based approaches. METHODS: In this randomised controlled trial, eligible patients were adult outpatients (age 18-80 years) who met the Rome III criteria for functional constipation and who had been referred to a tertiary-care centre after non-response to routine management, and who had dyssynergic defecation...
September 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30236903/home-based-biofeedback-for-dyssynergic-defecation
#4
Henriette Heinrich, Mark Fox
No abstract text is available yet for this article.
September 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30122356/comparative-efficacy-and-tolerability-of-pharmacological-agents-for-management-of-mild-to-moderate-ulcerative-colitis-a-systematic-review-and-network-meta-analyses
#5
Nghia H Nguyen, Mathurin Fumery, Parambir S Dulai, Larry J Prokop, William J Sandborn, Mohammad Hassan Murad, Siddharth Singh
BACKGROUND: The majority of patients with ulcerative colitis have mildly to moderately active disease. To inform the management of patients with left-sided or extensive mildly to moderately active ulcerative colitis, we assessed the comparative efficacy and tolerability of different therapies. METHODS: In this systematic review and network meta-analysis, we searched Epub, MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, and Web of Science from inception to Dec 14, 2015, and updated on MEDLINE on March 1, 2018, for randomised controlled trials in adults (age ≥17 years) with left-sided or extensive mild to moderate ulcerative colitis...
August 16, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30030069/a-village-without-hepatitis-c-in-egypt-will-micro-elimination-lead-to-macro-elimination
#6
Tarik Asselah
No abstract text is available yet for this article.
July 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30030068/an-educate-test-and-treat-programme-towards-elimination-of-hepatitis-c-infection-in-egypt-a-community-based-demonstration-project
#7
Gamal Shiha, Ammal M Metwally, Reham Soliman, Mohamed Elbasiony, Nabiel N H Mikhail, Philippa Easterbrook
BACKGROUND: Egypt has one of the highest prevalences and burdens of hepatitis C virus (HCV) worldwide, and a large government treatment programme. However, identifying and treating people who are infected in rural communities can be a substantial challenge. We designed and evaluated a comprehensive community-led outreach programme for prevention, testing, and treatment of HCV infection in one village in northern Egypt, with the goal to eliminate HCV infection from all adult villagers, and as a model for potential adoption in rural settings...
July 17, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30220407/nab-paclitaxel-plus-gemcitabine-with-or-without-capecitabine-and-cisplatin-in-metastatic-pancreatic-adenocarcinoma-pact-19-a-randomised-phase-2-trial
#8
Michele Reni, Silvia Zanon, Umberto Peretti, Marta Chiaravalli, Diletta Barone, Chiara Pircher, Gianpaolo Balzano, Marina Macchini, Silvia Romi, Elena Gritti, Elena Mazza, Roberto Nicoletti, Claudio Doglioni, Massimo Falconi, Luca Gianni
BACKGROUND: Current treatment for metastatic pancreatic ductal adenocarcinoma includes combination chemotherapy, such as FOLFIRINOX or nab-paclitaxel plus gemcitabine. We investigated the activity of a novel four-drug regimen, consisting of cisplatin, nab-paclitaxel, capecitabine, and gemcitabine, compared with nab-paclitaxel plus gemcitabine, in the PACT-19 trial. METHODS: This single-centre, randomised, open-label, phase 2 trial was done in San Raffaele Hospital in Italy...
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215364/correction-to-lancet-gastroenterol-hepatol-2018-3-593-95
#9
(no author information available yet)
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215363/idiopathic-recurrent-acute-pancreatitis
#10
REVIEW
Nalini M Guda, Guru Trikudanathan, Martin L Freeman
Idiopathic recurrent acute pancreatitis is clinically challenging and has substantial socioeconomic consequences. Investigations are expensive and often reveal little about the cause of the disease. Little is known about the interaction between genetic, environmental, anatomical, and other factors that contribute to the disease. Data on the efficacy, safety, and long-term outcomes of endoscopic therapies are scarce. The effect of idiopathic recurrent pancreatitis on quality of life is often underestimated. A more thorough examination of the causes of the disease and the roles of other associated risk factors is needed, as are well designed clinical studies with robust and objectively measurable outcomes...
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215362/emerging-non-invasive-approaches-for-diagnosis-and-monitoring-of-portal-hypertension
#11
REVIEW
Xiaolong Qi, Annalisa Berzigotti, Andres Cardenas, Shiv Kumar Sarin
Clinically significant portal hypertension is associated with an increased risk of developing gastro-oesophageal varices and hepatic decompensation. Hepatic venous pressure gradient measurement and oesophagogastroduodenoscopy are the gold-standard methods for assessing clinically significant portal hypertension (hepatic venous pressure gradient ≥10 mm Hg) and gastro-oesophageal varices, respectively. However, invasiveness, cost, and feasibility limit their widespread use, especially if repeated and serial evaluations are required to assess the efficacy of pharmacotherapy...
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215361/william-arbuthnot-lane-kink-catastrophe
#12
Talha Khan Burki
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215360/nigeria-s-complicated-hepatitis-burden
#13
Alex Abutu
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215359/when-clean-eating-goes-dirty
#14
Heidi M Staudacher, Kimberly N Harer
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215357/new-york-state-announces-initiative-to-eliminate-hepatitis-c
#15
Roxanne Nelson
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215356/one-step-closer-to-elimination-of-hepatitis-c-in-egypt
#16
LETTER
Gamal Esmat, Manal Hamdy El-Sayed, Mohamed Hassany, Wahid Doss, Imam Waked
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215355/future-directions-in-therapeutic-gastrointestinal-endoscopy
#17
Colin J Rees, Sara Koo, Kofi W Oppong
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215354/the-public-health-challenge-of-liver-cancer-in-mongolia
#18
Ariana Znaor, Tuvshinjargal Chimed, Mathieu Laversanne, Undarmaa Tudev, Erdenechimeg Sanjaajamts, Tuvshingerel Sandagdorj, Freddie Bray
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215353/chemotherapy-for-pancreatic-cancer-the-rise-of-multidrug-regimens
#19
David Malka, Ivan Borbath, Thierry Conroy
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/30215352/organ-donation-presumed-consent-is-not-enough
#20
EDITORIAL
The Lancet Gastroenterology Hepatology
No abstract text is available yet for this article.
October 2018: Lancet. Gastroenterology & Hepatology
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