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Stroke and Vascular Neurology

journal
https://www.readbyqxmd.com/read/30294476/correction-ginkgo-biloba-extract-improved-cognitive-and-neurological-functions-of-acute-ischaemic-stroke-a-randomised-controlled-trial
#1
(no author information available yet)
[This corrects the article DOI: 10.1136/svn-2017-000104.].
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294475/ped-flex-with-shield-technology-a-feasible-alternative-for-fusiform-mca-aneurysms
#2
Guilherme J Agnoletto, Pedro Aguilar-Salinas, Roberta Santos, Eric Sauvageau, Ricardo A Hanel
No abstract text is available yet for this article.
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294474/stenting-for-symptomatic-intracranial-arterial-stenosis-in-china-1-year-outcome-of-a-multicentre-registry-study
#3
Ning Ma, Yong Zhang, Jie Shuai, Changchun Jiang, Qiyi Zhu, Kangning Chen, Li Liu, Baomin Li, Xiangqun Shi, Lianbo Gao, Yajie Liu, Feng Wang, Yongli Li, Tieyan Liu, Hongbo Zheng, Dapeng Mo, Feng Gao, Yilong Wang, Yongjun Wang, Lei Feng, Zhongrong Miao
Background and purpose: A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis (ICAS) combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable. However, it remained uncertain whether the low event rate could be of a long term. We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294473/procedural-complexity-independent-of-p2y12-reaction-unit-pru-values-is-associated-with-acute-in-situ-thrombosis-in-pipeline-flow-diversion-of-cerebral-aneurysms
#4
Bowen Jiang, Matthew T Bender, Erick M Westbroek, Jessica K Campos, Li-Mei Lin, Risheng Xu, Rafael J Tamargo, Judy Huang, Geoffrey P Colby, Alexander L Coon
Background: Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device (PED) procedures with potentially high morbidity and mortality. There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events. There is limited knowledge on whether procedural complexity influences these events. Methods: Data were collected retrospectively on 742 consecutive PED cases at a single institution...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294472/association-between-admission-haematocrit-and-mortality-among-men-with-acute-ischaemic-stroke
#5
Jason J Sico, Laura J Myers, Brenda J Fenton, John Concato, Linda S Williams, Dawn M Bravata
Objective: Anaemia is associated with higher mortality among patients with non-stroke cardiovascular conditions; less is known regarding the relationship between anaemia and mortality among patients with acute ischaemic stroke. Methods: Medical records were abstracted for n=3965 veterans from 131 Veterans Health Administration facilities who were admitted with ischaemic stroke in fiscal year 2007. Haematocrit values within 24 hours of admission were classified as ≤27%, 28%-32%, 33%-37%, 38%-42%, 43%-47% or ≥48%...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294471/post-stroke-mrna-expression-profile-of-mmps-effect-of-genetic-deletion-of-mmp-12
#6
Koteswara Rao Nalamolu, Bharath Chelluboina, Ian B Magruder, Diane N Fru, Adithya Mohandass, Ishwarya Venkatesh, Jeffrey D Klopfenstein, David M Pinson, Krishna M Boini, Krishna Kumar Veeravalli
Background and purpose: Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases (MMPs) in rats and the detrimental role of MMP-12 in post-stroke brain damage. We hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other MMPs. We tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout mice...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294470/registry-report-on-prediction-by-pocock-cardiovascular-score-of-cerebral-microemboli-acutely-following-carotid-endarterectomy
#7
Mahmud Saedon, Athanasios Saratzis, Rachel W S Lee, Charles E Hutchinson, Christopher H E Imray, Donald R J Singer
Background: Cerebral microemboli may lead to ischaemic neurological complications after carotid endarterectomy (CEA). The association between classical cardiovascular risk factors and acute cerebral microemboli following carotid surgery has not been studied. The aim of this study was to explore whether an established cardiovascular risk score (Pocock score) predicts the presence of cerebral microemboli acutely after CEA. Subjects and methods: Pocock scores were assessed for the 670 patients from the Carotid Surgery Registry (age 71±1 (SEM) years, 474 (71%) male, 652 (97%) Caucasian) managed from January 2002 to December 2012 in the Regional Vascular Centre at University Hospitals Coventry and Warwickshire NHS Trust, which serves a population of 950 000...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294469/stenting-for-intracranial-stenosis-potential-future-for-the-prevention-of-disabling-or-fatal-stroke
#8
Wengui Yu, Wei-Jian Jiang
Intracranial stenosis is a common cause of ischaemic strokes, in particular, in the Asian, African and Hispanic populations. The randomised multicentre study Stenting and Aggressive Medical Management for the Prevention of Recurrent stroke in Intracranial Stenosis (SAMMPRIS) showed 14.7% risk of stroke or death in the stenting group versus 5.8% in the medical group at 30 days, and 23% in the stenting group versus 15% in the medical group at a median follow-up of 32.4 months. The results demonstrated superiority of medical management over stenting and have almost put the intracranial stenting to rest in recent years...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294468/contribution-of-diffusion-perfusion-and-functional-mri-to-the-disconnection-hypothesis-in-subcortical-vascular-cognitive-impairment
#9
Qing Ye, Feng Bai
Vascular cognitive impairment (VCI) describes all forms of cognitive impairment caused by any type of cerebrovascular disease. Early identification of VCI is quite difficult due to the lack of both sensitive and specific biomarkers. Extensive damage to the white matter tracts, which connect the cortical and subcortical regions, has been shown in subcortical VCI (SVCI), the most common subtype of VCI that is caused by small vessel disease. Two specific MRI sequences, including diffusion tensor imaging (DTI) and functional MRI (fMRI), have emerged as useful tools for identifying subtle white matter changes and the intrinsic connectivity between distinct cortical regions...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30294467/guidelines-for-evaluation-and-management-of-cerebral-collateral-circulation-in-ischaemic-stroke-2017
#10
Liping Liu, Jing Ding, Xinyi Leng, Yuehua Pu, Li-An Huang, Anding Xu, Ka Sing Lawrence Wong, Xin Wang, Yongjun Wang
Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute, subacute or chronic phases after an ischaemic stroke or transient ischaemic attack. Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment. Over the past decade, the importance of collateral circulation has attracted more attention and is becoming a hot spot for research...
September 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30191075/exercise-for-stroke-prevention
#11
REVIEW
Peter L Prior, Neville Suskin
We review evidence concerning exercise for stroke prevention. Plausible biological reasons suggest that exercise would be important in preventing stroke. While definitive randomised controlled trials evaluating the impact of physical activity (PA) and exercise on preventing stroke and mortality are lacking, observational studies, small randomised controlled trials and meta-analyses have provided evidence that PA and exercise favourably modify stroke risk factors, including hypertension, dyslipidaemia, diabetes, sedentary lifestyle, obesity, excessive alcohol consumption and tobacco use...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022802/patent-foramen-ovale-and-cryptogenic-stroke-diagnosis-and-updates-in-secondary-stroke-prevention
#12
REVIEW
Kristy Yuan, Scott Eric Kasner
The patent foramen ovale (PFO), given its high prevalence in the general population and especially in patients with cryptogenic stroke, has long generated investigation and debate on its propensity for stroke by paradoxical embolism and its management for stroke prevention. The pendulum has swung for percutaneous PFO closure for secondary stroke prevention in cryptogenic stroke. Based on a review of current evidence, the benefit from PFO closure relies on careful patient selection: those under the age of 60 years with few to no vascular risk factors and embolic-appearing stroke deemed cryptogenic after thorough evaluation...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022801/cardioembolic-stroke-everything-has-changed
#13
REVIEW
J David Spence
Historically, because of the difficulty of using warfarin safely and effectively, many patients with cardioembolic stroke who should have been anticoagulated were instead given ineffective antiplatelet therapy (or no antithrombotic therapy). With the arrival of new oral anticoagulants that are not significantly more likely than aspirin to cause severe haemorrhage, everything has changed. Because antiplatelet agents are much less effective in preventing cardioembolic stroke, it is now more prudent to anticoagulate patients in whom cardioembolic stroke is strongly suspected...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022800/diet-for-stroke-prevention
#14
REVIEW
J David Spence
Lifestyle is far more important than most physicians suppose. Dietary changes in China that have resulted from increased prosperity are probably responsible for a marked rise in coronary risk in the past several decades, accelerating in recent years. Intake of meat and eggs has increased, while intake of fruits, vegetables and whole grains has decreased. Between 2003 and 2013, coronary mortality in China increased 213%, while stroke mortality increased by 26.6%. Besides a high content of cholesterol, meat (particularly red meat) contains carnitine, while egg yolks contain phosphatidylcholine...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022799/controlling-resistant-hypertension
#15
REVIEW
J David Spence
Resistant hypertension (failure to achieve target blood pressures with three or more antihypertensive drugs including a diuretic) is an important and preventable cause of stroke. Hypertension is highly prevalent in China (>60% of persons above age 65), and only ~6% of hypertensives in China are controlled to target levels. Most strokes occur among persons with resistant hypertension; approximately half of strokes could be prevented by blood pressure control. Reasons for uncontrolled hypertension include (1) non-compliance; (2) consumption of substances that aggravated hypertension, such as excess salt, alcohol, licorice, decongestants and oral contraceptives; (3) therapeutic inertia (failure to intensify therapy when target blood pressures are not achieved); and (4) diagnostic inertia (failure to investigate the cause of resistant hypertension)...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022798/dual-versus-mono-antiplatelet-therapy-for-acute-non-cardioembolic-ischaemic-stroke-or-transient-ischaemic-attack-a-systematic-review-and-meta-analysis
#16
Yingying Yang, Mengyuan Zhou, Xi Zhong, Yongjun Wang, Xingquan Zhao, Liping Liu, Yilong Wang
Objective: Recent years have seen new evidence on the efficacy and safety of dual antiplatelet therapy for secondary stroke prevention. We updated a meta-analysis of randomised controlled trials evaluating dual antiplatelet versus monotherapy for patients with acute non-cardioembolic ischaemic stroke (IS) or transient ischaemic attack (TIA). Methods: We searched PubMed and identified randomised controlled trials evaluating dual antiplatelet versus monotherapy for acute non-cardioembolic IS or TIA within 3 days of ictus up to May 2018...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022797/endarterectomy-versus-stenting-for-stroke-prevention
#17
REVIEW
A Ross Naylor
The European Society for Vascular Surgery (ESVS) has recently prepared updated guidelines for the management of patients with symptomatic and asymptomatic atherosclerotic carotid artery disease, with specific reference to the roles of best medical therapy, carotid endarterectomy (CEA) and carotid artery stenting (CAS). In symptomatic patients, there is a drive towards performing carotid interventions as soon as possible after onset of symptoms. This is because it is now recognised that the highest risk period for recurrent stroke is the first 7-14 days after onset of symptoms...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022796/stroke-prevention-editorial-to-accompany-june-issue-of-svn
#18
REVIEW
J David Spence
No abstract text is available yet for this article.
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022795/how-to-identify-which-patients-with-asymptomatic-carotid-stenosis-could-benefit-from-endarterectomy-or-stenting
#19
REVIEW
Kosmas I Paraskevas, Frank J Veith, J David Spence
Offering routine carotid endarterectomy (CEA) or carotid artery stenting (CAS) to patients with asymptomatic carotid artery stenosis (ACS) is no longer considered as the optimal management of these patients. Equally suboptimal, however, is the policy of offering only best medical treatment (BMT) to all patients with ACS and not considering any of them for prophylactic CEA. In the last few years, there have been many studies aiming to identify reliable predictors of future cerebrovascular events that would allow the identification of patients with high-risk ACS and offer a prophylactic carotid intervention only to these patients to prevent them from becoming symptomatic...
June 2018: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/30022794/b-vitamins-for-stroke-prevention
#20
REVIEW
Graeme J Hankey
Supplementation with B vitamins (vitamin B9 (folic acid), vitamin B12 and vitamin B6 ) lowers blood total homocysteine (tHcy) concentrations by about 25% and reduces the relative risk of stroke overall by about 10% (risk ratio (RR) 0.90, 95% CI 0.82 to 0.99) compared with placebo. Homocysteine-lowering interventions have no significant effect on myocardial infarction, death from any cause or adverse outcomes. Factors that appear to modify the effect of B vitamins on stroke risk include low folic acid status, high tHcy, high cyanocobalamin dose in patients with impaired renal function and concurrent antiplatelet therapy...
June 2018: Stroke and Vascular Neurology
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