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Cannabis and Cannabinoid Research

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https://www.readbyqxmd.com/read/29992186/development-of-a-cannabinoid-based-photoaffinity-probe-to-determine-the-%C3%AE-8-9-tetrahydrocannabinol-protein-interaction-landscape-in-neuroblastoma-cells
#1
Marjolein Soethoudt, Georgios Alachouzos, Eva J van Rooden, María Dolores Moya-Garzón, Richard J B H N van den Berg, Laura H Heitman, Mario van der Stelt
Introduction: Δ9 -Tetrahydrocannabinol (THC), the principle psychoactive ingredient in Cannabis , is widely used for its therapeutic effects in a large variety of diseases, but it also has numerous neurological side effects. The cannabinoid receptors (CBRs) are responsible to a large extent for these, but not all biological responses are mediated via the CBRs. Objectives: The identification of additional target proteins of THC to enable a better understanding of the (adverse) physiological effects of THC. Methods: In this study, a chemical proteomics approach using a two-step photoaffinity probe is applied to identify potential proteins that may interact with THC...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29992185/identification-of-synergistic-interaction-between-cannabis-derived-compounds-for-cytotoxic-activity-in-colorectal-cancer-cell-lines-and-colon-polyps-that-induces-apoptosis-related-cell-death-and-distinct-gene-expression
#2
Rameshprabu Nallathambi, Moran Mazuz, Dvory Namdar, Michal Shik, Diana Namintzer, Ajjampura C Vinayaka, Aurel Ion, Adi Faigenboim, Ahmad Nasser, Ido Laish, Fred M Konikoff, Hinanit Koltai
Introduction: Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide. Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. However, the active compounds from Cannabis sativa flowers and their interactions remain elusive. Research Aim: This study was aimed to specify the cytotoxic effect of C. sativa -derived extracts on colon cancer cells and adenomatous polyps by identification of active compound(s) and characterization of their interaction...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29789813/cannabis-for-the-management-of-cancer-symptoms-thc-version-2-0
#3
Manuel Guzmán
No abstract text is available yet for this article.
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29789812/cannabis-and-the-opioid-crisis
#4
Daniele Piomelli, Susan Weiss, Graham Boyd, Rosalie Liccardo Pacula, Ziva Cooper
No abstract text is available yet for this article.
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29682609/prolonged-cannabidiol-treatment-effects-on-hippocampal-subfield-volumes-in-current-cannabis-users
#5
Camilla Beale, Samantha J Broyd, Yann Chye, Chao Suo, Mark Schira, Peter Galettis, Jennifer H Martin, Murat Yücel, Nadia Solowij
Introduction: Chronic cannabis use is associated with neuroanatomical alterations in the hippocampus. While adverse impacts of cannabis use are generally attributed to Δ9 -tetrahydrocannabinol, emerging naturalistic evidence suggests cannabidiol (CBD) is neuroprotective and may ameliorate brain harms associated with cannabis use, including protection from hippocampal volume loss. This study examined whether prolonged administration of CBD to regular cannabis users within the community could reverse or reduce the characteristic hippocampal harms associated with chronic cannabis use...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29682608/-hallucinations-following-acute-cannabis-dosing-a-case-report-and-comparison-to-other-hallucinogenic-drugs
#6
Frederick S Barrett, Nicolas J Schlienz, Natalie Lembeck, Muhammad Waqas, Ryan Vandrey
Introduction: Cannabis has been historically classified as a hallucinogen. However, subjective cannabis effects do not typically include hallucinogen-like effects. Empirical reports of hallucinogen-like effects produced by cannabis in controlled settings, particularly among healthy research volunteers, are rare and have mostly occurred after administration of purified Δ-9 tetrahydrocannabinol (THC) rather than whole plant cannabis. Methods: The case of a healthy 30-year-old male who experienced auditory and visual hallucinations in a controlled laboratory study after inhaling vaporized cannabis that contained 25 mg THC (case dose) is presented...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29662957/new-york-physicians-perspectives-and-knowledge-of-the-state-medical-marijuana-program
#7
Alexandra Sideris, Fahad Khan, Alina Boltunova, Germaine Cuff, Christopher Gharibo, Lisa V Doan
Introduction: In 2014, New York (NY) became the 23rd state to legalize medical marijuana (MMJ). The purpose of this survey was to collect data about practicing NY physicians' comfort level, opinions, and experience in recommending or supporting patient use of MMJ. Materials and Methods: An anonymous web-based survey was distributed to medical societies and to academic departments in medical schools within NY. Results: A total of 164 responses were analyzed. Physician participants were primarily located in New York City and surrounding areas...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29607411/verbal-memory-performance-and-reduced-cortical-thickness-of-brain-regions-along-the-uncinate-fasciculus-in-young-adult-cannabis-users
#8
Nina Levar, Alan N Francis, Matthew J Smith, Wilson C Ho, Jodi M Gilman
Introduction: Memory impairment is one of the most commonly reported effects of cannabis use, especially among those who initiate use earlier, perhaps due to the effects of delta-9- tetrahydrocannabinol on cannabinoid (CB1) receptors in the brain. Studies have increasingly investigated whether cannabis use is associated with impairments in verbal memory, and with alterations in brain structures underlying verbal memory. The uncinate fasciculus (UF), a long-range white matter tract, connects regions with densely localized CB1 receptors that are important in verbal memory...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29607410/willingness-to-participate-in-longitudinal-research-among-people-with-chronic-pain-who-take-medical-cannabis-a-cross-sectional-survey
#9
Marcus A Bachhuber, Julia H Arnsten, Joanna L Starrels, Chinazo O Cunningham
Background: Regulatory barriers limit clinical trials of medical cannabis in the United States. Longitudinal cohort studies may be one feasible alternative that could yield clinically relevant information. Willingness to participate in such studies is not known. Materials and Methods: In October 2016, we surveyed a convenience sample of patients with chronic pain from two New York registered organizations (responsible for growing, processing, distributing, and retailing medical cannabis products). After a vignette describing a longitudinal cohort study involving weekly patient-reported outcomes and quarterly assessments of physical functioning and urine and blood tests, we asked about respondents' willingness to participate...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29607409/a-novel-observational-method-for-assessing-acute-responses-to-cannabis-preliminary-validation-using-legal-market-strains
#10
L Cinnamon Bidwell, Raeghan Mueller, Sophie L YorkWilliams, Sarah Hagerty, Angela D Bryan, Kent E Hutchison
Background: The development of novel cannabis research methods that are compatible with current federal regulations is imperative to conduct studies of the effects of legal market cannabis. There is very little research on higher strength, higher Δ9-tetrahydrocannabinol (THC), which has become increasingly available since legalization. Research on strains containing cannabidiol (CBD), a second primary, but nonpsychotomimetic, cannabinoid, is very limited. Materials and Methods: Using a novel observational methodology, regular cannabis users were asked to use one of two legal market cannabis strains that they purchased from a local dispensary (one strain containing 8% THC and 16% CBD (THC+CBD) and one containing a 17% THC concentration, but no CBD (THC)...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29607408/therapeutic-effects-of-prolonged-cannabidiol-treatment-on-psychological-symptoms-and-cognitive-function-in-regular-cannabis-users-a-pragmatic-open-label-clinical-trial
#11
Nadia Solowij, Samantha J Broyd, Camilla Beale, Julie-Anne Prick, Lisa-Marie Greenwood, Hendrika van Hell, Chao Suo, Peter Galettis, Nagesh Pai, Shanlin Fu, Rodney J Croft, Jennifer H Martin, Murat Yücel
Introduction: Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While Δ9 -tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, cannabidiol (CBD) is purported to have antipsychotic properties and to ameliorate cognitive, symptomatic, and brain harms in cannabis users. However, this has never been tested in a prolonged administration trial in otherwise healthy cannabis users...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29588917/a-national-needs-assessment-of-canadian-nurse-practitioners-regarding-cannabis-for-therapeutic-purposes
#12
Lynda G Balneaves, Abeer Alraja, Daniel Ziemianski, Fairleth McCuaig, Mark Ware
Introduction: In Canada, the Access to Cannabis for Medical Purposes Regulations (ACMPR) has given nurse practitioners (NPs) the power to authorize cannabis for therapeutic purposes (CTP) to eligible patients. This expansion in NPs' scope of practice underscores the importance of delivering balanced, evidence-based education on cannabis to NPs. The aim of this national study was to assess NPs' knowledge and practice gaps related to CTP to inform the development of future education resources that increase NPs' clinical competence and improve patient care related to medical cannabis...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29588916/medicinal-cannabis-on-prescription-in-the-netherlands-statistics-for-2003-2016
#13
Bas de Hoop, Eibert R Heerdink, Arno Hazekamp
No abstract text is available yet for this article.
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29450258/the-cannabinoids-%C3%AE-8-thc-cbd-and-hu-308-act-via-distinct-receptors-to-reduce-corneal-pain-and-inflammation
#14
Dinesh Thapa, Elizabeth A Cairns, Anna-Maria Szczesniak, James T Toguri, Meggie D Caldwell, Melanie E M Kelly
Background and Purpose: Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CB1 R) and cannabinoid 2 (CB2 R) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia. Methods: Corneal hyperalgesia (increased pain response) was generated using chemical cauterization of the corneal epithelium in wild-type (WT) and CB2 R knockout (CB2 R-/- ) mice...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29404409/the-influence-of-dat1-comt-and-bdnf-genetic-polymorphisms-on-total-and-subregional-hippocampal-volumes-in-early-onset-heavy-cannabis-users
#15
Albert Batalla, Valentina Lorenzetti, Yann Chye, Murat Yücel, Carles Soriano-Mas, Sagnik Bhattacharyya, Marta Torrens, José A S Crippa, Rocío Martín-Santos
Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years...
2018: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29285522/cannabidiol-does-not-convert-to-%C3%AE-9-tetrahydrocannabinol-in-an-in-vivo-animal-model
#16
Louise Wray, Colin Stott, Nicholas Jones, Stephen Wright
Introduction: Cannabidiol (CBD) can convert to Δ9 -tetrahydrocannabinol (THC) in vitro with prolonged exposure to simulated gastric fluid; however, in vitro conditions may not be representative of the in vivo gut environment. Using the minipig, we investigated whether enteral CBD converts to THC in vivo . Materials and Methods: Synthetic CBD (100 mg/mL) was administered orally in a sesame oil formulation twice daily to minipigs ( N =3) in 15 mg/kg doses for 5 consecutive days. Blood samples were taken before and 1, 2, 4, and 6 h after morning doses on Days 1 and 5...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29098190/-cannabis-sativa-hemp-seeds-%C3%AE-9-tetrahydrocannabinol-and-potential-overdose
#17
Yi Yang, Melissa M Lewis, Angelica M Bello, Ewa Wasilewski, Hance A Clarke, Lakshmi P Kotra
Introduction: Cannabis sativa (hemp) seeds are popular for their high nutrient content, and strict regulations are in place to limit the amount of potentially harmful phytocannabinoids, especially Δ9 -tetrahydrocannabinol (Δ9 -THC). In Canada, this limit is 10 μg of Δ9 -THC per gram of hemp seeds (10 ppm), and other jurisdictions in the world follow similar guidelines. Materials and Methods: We investigated three different brands of consumer-grade hemp seeds using four different procedures to extract phytocannabinoids, and quantified total Δ9 -THC and cannabidiol (CBD)...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29098189/an-update-on-non-cb-1-non-cb-2-cannabinoid-related-g-protein-coupled-receptors
#18
REVIEW
Paula Morales, Patricia H Reggio
The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and pathological processes. To date, two Class A G-protein-coupled receptors (GPCRs) have been discovered and validated as the main therapeutic targets of this system: the cannabinoid receptor type 1 (CB1 ), which is the most abundant neuromodulatory receptor in the brain, and the cannabinoid receptor type 2 (CB2 ), predominantly found in the immune system among other organs and tissues. Endogenous cannabinoid receptor ligands (endocannabinoids) and the enzymes involved in their synthesis, cell uptake, and degradation have also been identified as part of the ECS...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29098188/translating-endocannabinoid-biology-into-clinical-practice-cannabidiol-for-stroke-prevention
#19
REVIEW
Eugene L Scharf
Introduction: The endocannabinoid system (ECS) regulates functions throughout human physiology, including neuropsychiatric, cardiovascular, autonomic, metabolic, and inflammatory states. The complex cellular interactions regulated by the ECS suggest a potential for vascular disease and stroke prevention by augmenting central nervous and immune cell endocannabinoid signaling. Discussion: The endocannabinoid N-arachidonoylethanolamine (anandamide) plays a central role in augmenting these processes in cerebrovascular and neurometabolic disease...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/29098187/review-the-role-of-cannabinoids-on-esophageal-function-what-we-know-thus-far
#20
REVIEW
Jonathan Gotfried, Rahul Kataria, Ron Schey
The endocannabinoid system (ECS) primarily consists of cannabinoid receptors (CBRs), endogenous ligands, and enzymes for endocannabinoid biosynthesis and inactivation. Although the presence of CBRs, both CB1 and CB2 , as well as a third receptor (G-protein receptor 55 [GPR55]), has been established in the gastrointestinal (GI) tract, few studies have focused on the role of cannabinoids on esophageal function. To date, studies have shown their effect on GI motility, inflammation and immunity, intestinal and gastric acid secretion, nociception and emesis pathways, and appetite control...
2017: Cannabis and Cannabinoid Research
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