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Asia Oceania Journal of Nuclear Medicine & Biology

Yuji Tsutsui
No abstract text is available yet for this article.
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Tadaki Nakahara
No abstract text is available yet for this article.
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Batool Al Balooshi, Shabna Miyanath, Amr Elhennawy, Yaser Saeedi, Syed Hammad Tirmazy, Muhammed Muhasin, Bhavna Ray, Mouza Al Sharhan, Hassan Hotait, Yamina Houcinat, Tasnim Keloth
F-18 FDG is the most widely used tracer in molecular imaging and it is applied for many purposes mainly in malignant diseases. Incidental finding are common in FDG-PET/CT imaging and includes benign and malignant lesions. Among the rare tumors‎, adrenal oncocytomas are uncommon findings and incidental findings of thyroid malignancies are not rare. Oncocytoma is a rare adrenocortical tumor and majority of bulky adrenal tumors are benign with uncertain incident of malignancy. In this study, we are reporting a 37-year-old man with two incidental malignancies detected by FDG-PET-CT...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Patrick Earl A Fernando, Patricia A Bautista
Parathyroid carcinoma is very rare, with only a few documented cases. Hence, metastatic lesions are infrequently documented on scintigraphic imaging. We present a case of a 63-year-old female presenting with elevated serum levels of ionized calcium and parathyroid hormone (PTH) who was referred to our department for a parathyroid scan with SPECT/CT. Parathyroid scintigraphy showed a focus of increased 99m Tc-sestamibi uptake corresponding to a solid mass with calcification in the inferior pole of the right thyroid lobe; tracer retention was noted on delayed images...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Sara Shakeri, Soroush Zarehparvar Moghadam, Ramin Sadeghi, Narjess Ayati
Sagliker syndrome is a rare form of renal osteodystrophy resulted from untreated secondary hyperparathyroidism. It is described by severe skeletal deformities, high level of PTH in patients with chronic renal failure, and deformed face. This paper reports a 44-year-old male patient with the mentioned characteristics. In addition to the unique clinical features, high levels of ALP and PTH hormones encouraged us to search for syndrome-like a disease, which clinically and paraclinically matched the Sagliker syndrome...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Raita Araki, Ryosei Nishimura, Anri Inaki, Hiroshi Wakabayashi, Yasuhito Imai, Yoshikazu Kuribayashi, Kenichi Yoshimura, Toshinori Murayama, Seigo Kinuya
Objectives: High-risk neuroblastoma is a childhood cancer with poor prognosis despite modern multimodality therapy. Internal radiotherapy using 131 I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it is resistant to chemotherapy. The aim of this study is to evaluate the safety and efficacy of 131 I-MIBG radiotherapy combined with myeloablative high-dose chemotherapy and hematopoietic stem cell transplantation. Methods: Patients with high-risk neuroblastoma will be enrolled in this study...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Saeed Farzanefar, Rahman Etemadi, Mohammad Shirkhoda, Habibollah Mahmoodzadeh, Mostafa Erfani, Babak Fallahi, Mehrshad Abbasi, Narjess Ayati, Arman Hassanzadeh-Rad, Mohammad Eftekhari, Davood Beiki
Objectives: Malignant melanoma is the most lethal type of skin cancers with unfavorable prognosis. Alpha-MSH peptide analogues have a high affinity for melanocortine-1 (MC1) receptors on melanocytes over expressing in malignant melanoma cells. Pre-clinical studies have shown promising results for radiolabeled MSH imaging in this malignancy. The purpose of this study is to assess the diagnostic value of 99m Tc-α-MSH imaging in malignant melanoma. Methods: Twenty-one patients (13 men) with pathologically confirmed malignant melanoma with or without metastatic distribution were included in this study...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Yasukazu Kanai, Yoshinori Miyake, Eku Shimosegawa, Jun Hatazawa
Objectives: Phenytoin is an antiepileptic drug that is used worldwide. The whole-body pharmacokinetics of this drug have been extensively studied using 11 C-phenytoin in small animals. However, because of the limited production amounts that are presently available, clinical 11 C-phenytoin PET studies to examine the pharmacokinetics of phenytoin in humans have not yet been performed. We aimed to establish a new synthesis method to produce large amounts of 11 C-phenytoin to conduct human studies...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Hideo Onishi, Takayuki Sakai, Osamu Shiromoto, Hizuru Amijima
Objectives: The partial volume effect (PVE) of single-photon emission computed tomography (SPECT) on corpus striatum imaging is caused by the underestimation of specific binding ratio (SBR). A large ROI (region of interest) set using the Southampton method is independent of PVE for SBR. The present study aimed to determine the optimal ROI size with contrast and SBR for striatum images and validate the Southampton method using a three-dimensional mathematical cylinder (3D-MAC) phantom...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Yoshito Kamiya, Satoru Ota, Yuta Tanaka, Kosuke Yamashita, Akihiro Takaki, Shigeki Ito
Objectives: We recently developed a new uptake index method for 123 I-metaiodobenzylguanidine (123 I-MIBG) heart uptake measurements by using planar images (radioisotope angiography and planar image) for the diagnosis of Lewy body disease (LBD), including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, the diagnostic accuracy of the uptake index was approximately equal to that of the heart-to-mediastinum ratio (H/M) for the discrimination of the LBD and non-LBD patients...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Keishin Morita, Akira Maebatake, Rina Iwasaki, Yuki Shiotsuki, Kazuhiko Himuro, Shingo Baba, Masayuki Sasaki
Objectives: The purpose of this study was to examine the optimal reconstruction parameters for brain dopamine transporter SPECT images obtained with a fan beam collimator and compare the results with those obtained by using parallel-hole collimators. Methods: Data acquisition was performed using two SPECT/CT devices, namely a Symbia T6 and an Infinia Hawkeye 4 (device A and B) equipped with fan-beam (camera A-1 and B-1), low- and medium-energy general-purpose (camera A-2 and B-2), and low-energy high-resolution (camera A-3 and B-3) collimators...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Kathy P Willowson, HyunJu Ryu, Price Jackson, Anita Singh, Enid Eslick, Dale L Bailey
Objectives: To investigate and compare quantitative accuracy of kidney absorbed dose measures made from both 2D and 3D imaging in patients receiving 177 Lu-DOTATATE (Lutate) for treatment of neuroendocrine tumours (NETs). Methods: Patients receiving Lutate therapy underwent both whole body planar imaging and SPECT/CT imaging over the kidneys at time points 0.5, 4, 24, and 96-120 hours after injection. Planar data were corrected for attenuation using transmission data, and were converted to units of absolute activity via two methods, using either a calibration standard in the field of view or relative to pre-voiding image total counts...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Ramin Ashrafpour, Narjess Ayati, Ramin Sadeghi, Samira Zare Namdar, Nayyereh Ayati, Somayyeh Ghahremani, Seyed Rasoul Zakavi
Objectives: TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of 150 µg dose of Levothyroxine by use of a100 and a 50 µg tablets or one and half 100 µg tablets in Differentiated thyroid cancer (DTC) patients...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Maryam Sahebari, Zahra Rezaieyazdi, Mandana Khodashahi, Bita Abbasi, Fazlollah Ayatollahi
Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease with a wide range of clinical manifestations. Cognitive dysfunction is one of the manifestations that could present prior to the emergence of any other neuropsychiatric involvements in SLE. Cognitive dysfunction is a subtle condition occurring with a high frequency. However, there is no data on the correlation of cognitive dysfunction with central nervous system (CNS) imaging findings, in particular single-photon emission computed tomography scan (SPECT) and functional MRI...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Ryuto Otsuka, Yosuke Miyazaki, Narumi Kubo, Mio Kawahara, Jun Takaesu, Kazuki Fukuchi
Objectives: To appropriately use one-day myocardial perfusion imaging (MPI) with 99m Tc radiopharmaceuticals (i.e. to avoid shine-through artifacts), injection doses need to be optimized and dose ratios between the 1st and 2nd scans should be maintained at ≥ 3. However, the current state of practice in Japan is unclear. Thus, the aim of this study was to clarify the details of MPI protocols using 99m Tc radiopharmaceuticals in Japan. Methods: A nationwide survey was conducted in June and July 2016...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Maimoona Siddique, M Khalid Nawaz, Humayun Bashir
Objectives: This study sought to determine the diagnostic yield of SPECT/CT in localizing axillary sentinel lymph nodes (SLNs) in early breast cancer patients where planar scintigraphy (PS) was equivocal or negative. Methods: Prospective analysis of early stage breast cancer patients with non-palpable axillary nodes undergoing SLN localization prior to nodal sampling for axillary staging. PS findings were categorized as: Category A: non-visualization of SLN; Category B: unusual uptake location; Category C: equivocal uptake / difficult interpretation...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Rashid Hashmi
This mage-based series comprises of a quiz pertaining to the identification of salient and important anatomical structures and landmarks expected to be seen at a given level on the computed tomography (CT). The representative image is followed by a series of images showing the examples of different commonly encountered pathological entities that can be seen at this level in a routine clinical practice. Readers are encouraged to identify the highlighted anatomical structures and landmarks in all the images and appreciate the alterations in the appearance of the normal structures resulting from the presence of a pathology...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Win Mar
Nuclear Medicine was established in Myanmar in 1963 by Dr Soe Myint and International Atomic Energy expert Dr R. Hochel at Yangon General Hospital. Nuclear medicine diagnostic and therapeutic services started with Probe Scintillation Detector Systems and rectilinear scanner. In the early stage, many Nuclear Medicine specialists from the International Atomic Energy Agency (IAEA) spent some time in Myanmar and made significant contributions to the development of Nuclear Medicine in our country. The department participated in various IAEA technical cooperation projects and regional cooperation projects...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Kaoru Maruyama, Keita Utsunomia, Takahiro Nakamoto, Shigenari Kawakita, Takashi Murota, Noboru Tanigawa
A 76-year-old man with symptomatic bone metastases from castration-resistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or relapse. Some lesions showed decrease and some lesions showed increase on Tc-99m hydroxymethylene diphosphonate bone scintigraphy at two weeks after the third injection of Ra-223 therapy...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Farnaz Banezhad, Narjess Ayati, Farrokh Seilanian Toosi, Samine Boloursaz, S Rasoul Zakavi
Extraosseous accumulation of technetium-99m-methyl diphosphonate (99m Tc-MDP) on bone scan is not common. This phenomenon is often attributed to abnormality of calcium metabolism and has been reported in a variety of conditions including metabolic diseases and malignancies. A five years old boy is presented here, who was admitted to the pediatric emergency suffering from fatigue, respiratory symptoms, weight loss, intermittent fevers, anorexia, nausea and vomiting, edema of legs and abdominal distension for one month...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
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