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Stem Cell Investigation

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https://www.readbyqxmd.com/read/28725656/expression-of-vox-and-vent-mrnas-and-encoded-proteins-in-zebrafish-embryos
#1
Elena S Pshennikova, Maria B Tereshina, Anna S Voronina
In Danio rerio (zebrafish), members of the vent gene-family (vox/vega1, vent/vega2) are considered as ventralizing factors. We investigated not only the expression of their mRNAs by in situ hybridization at different stages of embryonic development, but also the spatial distribution of the encoded proteins by whole-mount immunostaining. We showed vox mRNA to be available in embryos since early cleavage and later on. Vent mRNA appeared after zygotic genome activation only. The vox and vent proteins were revealed at stage of eight blastomeres...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725655/cell-replacement-therapy-is-the-remedial-solution-for-treating-parkinson-s-disease
#2
REVIEW
Venkatesan Dhivya, Vellingiri Balachandar
The selective degeneration of dopaminergic (DA) neurons in Parkinson's disease (PD) has made an idol target for cell replacement therapies and other emerging surgical treatments. Certainly, by transplantation method, the therapeutic regimens such as human fetal ventral midbrain (hfVM) cells, human embryonic stem cells (hESCs), human neural stem/precursor/ progenitor cells (hNSCs/hNPCs), human mesenchymal stem cells (hMSCs), human induced neural stem cells (hiNSCs), and human induced pluripotent stem cells (hiPSCs) have been used into DA deficient striatum...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725654/stem-cells-from-human-hair-follicles-first-mechanical-isolation-for-immediate-autologous-clinical-use-in-androgenetic-alopecia-and-hair-loss
#3
Pietro Gentile, Maria G Scioli, Alessandra Bielli, Augusto Orlandi, Valerio Cervelli
BACKGROUND: Hair follicles are known to contain a well-characterized niche for adult stem cells: the bulge, which contains epithelial and melanocytic stem cells. Stem cells in the hair bulge, a clearly demarcated structure within the lower permanent portion of hair follicles, can generate the interfollicular epidermis, hair follicle structures, and sebaceous glands. The bulge epithelial stem cells can also reconstitute in an artificial in vivo system to a new hair follicle. METHODS: In this study, we have developed a new method to isolate human adult stem cells by mechanical centrifugation of punch biopsy from human hair follicles without culture condition...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725653/calr-positive-myeloproliferative-disorder-in-a-patient-with-ph-positive-chronic-myeloid-leukemia-in-durable-treatment-free-remission-a-case-report
#4
Irene Dogliotti, Carmen Fava, Anna Serra, Enrico Gottardi, Filomena Daraio, Francesca Carnuccio, Emilia Giugliano, Monica Bocchia, Giuseppe Saglio, Giovanna Rege-Cambrin
Current diagnostic criteria for Philadelphia-negative myeloproliferative neoplasia (MPN) have been redefined by the discovery of Janus kinase 2 (JAK2), myeloproliferative leukemia (MPL) and calreticulin (CALR) genetic alterations. Only few cases of coexistence of CALR-mutated MPN and Philadelphia-positive chronic myeloid leukemia (CML) have been described so far. Here we report the case of a patient with CML diagnosed in 2001, treated with imatinib and pegylated interferon (IFN) frontline. She reached complete molecular remission (CMR) and discontinued imatinib, maintaining treatment free remission...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725652/rescuing-bmpr2-driven-endothelial-dysfunction-in-pah-a-novel-treatment-strategy-for-the-future
#5
EDITORIAL
Rozenn Quarck, Fréderic Perros
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725651/human-acute-leukemia-induced-pluripotent-stem-cells-a-unique-model-for-investigating-disease-development-and-pathogenesis
#6
EDITORIAL
Clara Bueno, Pablo Menendez
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725650/x-chromosome-activity-in-naive-human-pluripotent-stem-cells-are-we-there-yet
#7
EDITORIAL
Shafqat A Khan, Pauline N C B Audergon, Bernhard Payer
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725649/inducible-pluripotent-stem-cells-and-pulmonary-arterial-hypertension-the-future-is-now
#8
EDITORIAL
Monica Romero Lopez, Vinicio de Jesus Perez
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725648/deletion-with-25-nucleotides-of-tcr%C3%AE-gene-in-t-cells-from-a-case-with-chronic-myeloid-leukemia
#9
Yan Li, Jing Lai, Ziwei Liao, Lixin Guo, Bo Li, Kanger Zhu, Yangqiu Li
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725647/retraction-regulatory-factors-of-induced-pluripotency-current-status
#10
Wei Zhao, Bo Ning, Chen Qian
[This retracts the article on p. 15 in vol. 1, PMID: 27358861.].
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28725646/histone-chaperone-in-regulation-of-cellular-metabolism-dictating-stem-cell-fate
#11
EDITORIAL
Debasree Dutta
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607923/unsaturated-fatty-acids-regulate-stemness-of-ovarian-cancer-cells-through-nf-%C3%AE%C2%BAb
#12
EDITORIAL
Alejandro Parrales, Atul Ranjan, Tomoo Iwakuma
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607922/tyrosine-kinase-inhibitors-targeting-flt3-in-the-treatment-of-acute-myeloid-leukemia
#13
REVIEW
Yun Chen, Yihang Pan, Yao Guo, Wanke Zhao, Wanting Tina Ho, Jianlong Wang, Mingjiang Xu, Feng-Chun Yang, Zhizhuang Joe Zhao
Acute myeloid leukemia (AML) is a cancer of the myeloid lineage of blood cells. Although significant progress has been made in treating many types of cancers during recent years, AML remains a deadly disease with survival rate lagging behind other blood cancers. A combination of toxic chemotherapies has been the standard AML treatment for more than 40 years. With intensive efforts to define the pathogenesis of AML, novel therapeutic drugs targeting key molecular defects in AML are being developed. Mutated in nearly 30% of AML, FMS-like tyrosine kinase 3 (FLT3) represents one of the most attractive targets...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607921/graft-predominance-after-double-umbilical-cord-blood-transplantation-a-review
#14
REVIEW
Jan J Cornelissen, Burak Kalin, Cor H J Lamers
Several parameters are involved in graft predominance after double umbilical cord blood transplantation (dUCBT), of which T-cell alloreactivity between the grafts is now considered to be the major denominator. We recently showed that alloreactive CD4+ T-cells originating from the predominant CBU recognize HLA-class II allele mismatches and can readily be detected in the majority of patients. In addition, it was shown that HLA-class II allele-specific CD4+ T-cells were able to recognize primary leukemic cells when the mismatched HLA-class II allele was shared between the rejected CBU and the patient...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607920/epigenetics-meets-metabolism-through-phb-mediated-histone-h3-3-deposition-by-hira
#15
EDITORIAL
Ronen Marmorstein, Peter D Adams
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607919/the-mammary-stem-cell-field-wakes-up-to-hibernating-cells
#16
EDITORIAL
Ewa M Michalak
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607918/the-propensity-for-epithelial-mesenchymal-transitions-is-dictated-by-chromatin-states-in-the-cancer-cell-of-origin
#17
EDITORIAL
Alyssa A La Belle, William P Schiemann
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607917/thrombotic-microangiopathy-associated-with-synthetic-cannabinoid-receptor-agonists
#18
Michael Karass, Savneek Chugh, Gabriela Andries, Aleksandra Mamorska-Dyga, John C Nelson, Praveen N Chander
Marijuana is one of the most commonly used recreational drugs in the United States. As marijuana is illegal in the majority of countries, the use of readily available and unregulated synthetic cannabinoids (SCBs) has increased. Little is known about the potential adverse effects of SCBs especially in regards to their nephrotoxicity. Case reports of acute kidney injury (AKI) from acute tubular injury secondary to their use have been reported. However, the exact pathology, mechanism, and extent of renal injury remain unknown...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607916/observation-driven-inquiry-raman-spectroscopic-imaging-illuminates-cancer-lipid-metabolism
#19
EDITORIAL
Aurelio Lorico, Germana Rappa, Denis Corbeil, Thuc T Le
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28607915/engineering-cord-blood-to-improve-engraftment-after-cord-blood-transplant
#20
REVIEW
Rohtesh S Mehta, Hema Dave, Catherine M Bollard, Elizabeth J Shpall
Umbilical cord blood transplant (CBT) has traditionally been associated with slower engraftment of neutrophils, delayed immune reconstitution and consequently higher risk of infections as compared with peripheral blood progenitor cell (PBPC) or bone marrow (BM) transplants. This is primarily due to low numbers of total nucleated cells (TNCs) and the naive nature of CB immune cells. The use of double unit CB transplant (DCBT) increases the total cell dose in the graft, but it still does not produce as rapid engraftment as seen with PBPC or even BM transplants...
2017: Stem Cell Investigation
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