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Stem Cell Investigation

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https://www.readbyqxmd.com/read/29430460/cancer-stem-cells-and-evolving-novel-therapies-a-paradigm-shift
#1
REVIEW
Sangeetha Vasudevaraj Naveen, Kumar Kalaivani
Accumulating evidence of stem-like cells/cancer stem cells (CSCs) has been gaining attention of cancer researchers over the last decade. Though many tumors harbor CSCs in their dedicated niches, identifying and exterminating those cells has proved to be difficult, due to their heterogenous nature, as the CSC phenotype vary substantially and may undergo reversible phenotypic changes. As a tumor propagation initiator, CSCs are considered as an exciting novel therapy for a better therapeutic outcome. This review discusses the major advances in the development of CSC-based therapies of most common cancers which includes lung, cervix and liver cancers...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430459/organoids-recapitulate-organs
#2
EDITORIAL
Tohru Sugawara, Kengo Sasaki, Hidenori Akutsu
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430458/integrin-%C3%AE-7-a-novel-promising-target-in-glioblastoma-stem-cells
#3
EDITORIAL
Estefania Carrasco-Garcia, Jaione Auzmendi-Iriarte, Ander Matheu
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430457/evaluating-the-behavior-of-cultured-sertoli-cells-in-the-presence-and-absence-of-spermatogonial-stem-cell
#4
Masoome Jabarpour, Parviz Tajik
Background: The complex process of spermatogenesis is regulated by various factors. Several studies have been conducted to proliferate cells involved in the spermatogenesis process, in culture by used growth factors, different hormones and feeder cells. This study was conducted to evaluate the role of Sertoli cells on gene expression of fibroblast growth factor (FGF2) and glial cell derived neurotrophic factor (GDNF) after removal of spermatogonial stem cells (SSCs) from the culture medium...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359141/extracellular-vesicles-and-cardiovascular-disease-therapy
#5
REVIEW
Jérémy Amosse, Maria Carmen Martinez, Soazig Le Lay
Cardiovascular disease (CVD) constitutes one of the leading causes of mortality worldwide, therefore representing a major public health concern. Despite recent advances in the treatment of patients with acute myocardial infarction (AMI), such as bypass surgery or percutaneous coronary intervention, pathological cardiac remodeling often predisposes survivors to fatal heart failure. In this context, the proven efficacy of stem cell-regenerative therapies constitutes a promising therapeutic perspective with is nevertheless slow down by safety and ethical concerns...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359140/human-induced-pluripotent-stem-cell-derived-neuronal-progenitors-are-a-suitable-and-effective-drug-discovery-model-for-neurological-mtdna-disorders
#6
EDITORIAL
Jonas Walter, Sarah Louise Nickels, Jens Christian Schwamborn
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359139/acute-myeloid-leukemia-and-fatal-scedosporium-prolificans-sepsis-after-eculizumab-treatment-for-paroxysmal-nocturnal-hemoglobinuria-a-case-report
#7
Madhura Hanmantgad, Rajat Nog, Karen Seiter
Eculizumab has become the standard of care for patients with paroxysmal nocturnal hemoglobinuria (PNH). As more patients are treated, the long-term outcomes of these patients will become apparent. We recently treated a patient who developed PNH in the setting of aplastic anemia. The patient developed acute myeloid leukemia less than three years after initiating eculizumab. The patient also died suddenly from Scedosporium sepsis during induction therapy. This patient's course seemed more aggressive than would be expected...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359138/not-just-another-biomarker-the-role-of-integrin-alpha-7-in-glioblastoma
#8
EDITORIAL
Abigail Zalenski, Kuntal De, Monica Venere
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359137/extracellular-vesicles-and-aging
#9
REVIEW
Paul D Robbins
Aging and the chronic diseases associated with aging place a tremendous burden on our healthcare system. As our world population ages dramatically over the next decades, this will only increase. Hence, there is a great need to discover fundamental mechanisms of aging to enable development of strategies for minimizing the impact of aging on our health and economy. There is general agreement that cell autonomous mechanisms contribute to aging. As cells accrue damage over time, they respond to it by triggering individual cell fate decisions that ultimately disrupt tissue homeostasis and thus increase risk of morbidity...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359136/integrin-%C3%AE-7-a-major-driver-and-therapeutic-target-for-glioblastoma-malignancy
#10
EDITORIAL
Andreia M Nunes, Pamela Barraza-Flores, Christina R Smith, Dean J Burkin
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270422/breast-cancer-stem-cells-from-origins-to-targeted-therapy
#11
REVIEW
Woei Chyi Sin, Chooi Ling Lim
Breast cancer is marked as one of the leading causes of malignancy-related morbidities worldwide. In spite of aggressive interventions, the inevitability of relapse and metastasis severely impede survival rates. Mounting evidence highlight the insidious role of cancer stem cells (CSCs), a small but significant subpopulation of undifferentiated cells that drive tumour progression, spread and resistance to conventional therapy. The nature and significance of breast CSCs remains poorly understood, and even disputed by many researchers...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270421/stem-cell-transplant-in-inflammatory-bowel-disease-a-promising-modality-of-treatment-for-a-complicated-disease-course
#12
REVIEW
George A Salem, George B Selby
Inflammatory bowel disease (IBD) is a complex, relapsing and remitting, disease characterized by an exaggerated immune response in a susceptible host. The symptoms and complications of the disease can be debilitating. Advances in medical treatment in the last decade changed the course of the disease in many patients. Despite the use of novel agents for controlling disease, a proportion of patients' disease courses continue to be either refractory, or become resistant, to available therapeutic options. Stem-cell therapy, with hematopoietic stem cells (HSCs) or mesenchymal stem cells (MSCs), is a promising modality of treatment for severe refractory cases, mainly Crohn's disease (CD) patients...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270420/stem-cell-ophthalmology-treatment-study-bone-marrow-derived-stem-cells-in-the-treatment-of-non-arteritic-ischemic-optic-neuropathy-naion
#13
Jeffrey N Weiss, Steven Levy, Susan C Benes
Background: Ten patients with bilateral visual loss due to sequential non-arteritic ischemic optic neuropathy (NAION) underwent autologous Bone Marrow Derived Stem Cell (BMSC) therapy within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical study utilizing autologous BMSC in the treatment of optic nerve and retinal diseases that meet inclusion criteria. Methods: The average age of the patients treated was 69...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270419/beneficial-effects-of-exosomes-secreted-by-cardiac-derived-progenitor-cells-and-other-cell-types-in-myocardial-ischemia
#14
REVIEW
Lucio Barile, Giuseppina Milano, Giuseppe Vassalli
When injected into acutely infarcted rodent or pig hearts, naturally secreted nanovesicles known as exosomes from cardiac-derived progenitor cells (CPCs) reduce scar size and improve cardiac function. In this regard, exosomes fully mimic the benefits of injecting their parent cells. This recognition paves the way to the development of exosome-based, cell-free treatments for heart disease that could possibly supplant cell-based therapies. Mechanisms of benefit of these vesicles are incompletely understood but cytoprotection, stimulation of angiogenesis, induction of antifibrotic cardiac fibroblasts, and modulation of M1/M2 polarization of macrophages infiltrating the infarcted region can all play important roles...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270418/human-induced-pluripotent-stem-cells-illuminate-pathways-and-novel-treatment-targets-for-age-related-macular-degeneration
#15
EDITORIAL
Lindsay A Farrer, Margaret M DeAngelis
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270417/personalized-medicine-in-a-dish-the-growing-possibility-of-neuropsychiatric-disease-drug-discovery-tailored-to-patient-genetic-variants-using-stem-cells
#16
EDITORIAL
https://www.readbyqxmd.com/read/29270416/stem-cell-extracellular-vesicles-and-kidney-injury
#17
REVIEW
Cristina Grange, Corinne Iampietro, Benedetta Bussolati
Extracellular vesicles (EVs) appear as a new promising cell-free therapy for acute and chronic renal diseases. EVs retain characteristics of the cell of origin and those derived from stem cells may mimic their regenerative properties per se. In fact, EVs contain many active molecules such as proteins and RNA species that act on target cells through different mechanisms, stimulating proliferation and angiogenesis and reducing apoptosis and inflammation. There are several reports that demonstrate a general regenerative potential of EVs derived from mesenchymal stromal cells (MSCs) of different sources in kidney injury models...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270415/a-step-forward-in-disease-modelling-for-mitochondrial-diseases
#18
EDITORIAL
Filippo Zambelli, Claudia Spits
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270414/alopecia-and-platelet-derived-therapies
#19
John P Cole, Megan A Cole, Chiara Insalaco, Valerio Cervelli, Pietro Gentile
Background: Platelet rich plasma (PRP) injections have emerged as a promising regenerative therapy for androgenetic alopecia (AGA). To date, injections of both autologous native and activated PRP have been administered to hair loss patients, and positive results have been observed. However, little to no work has yet to be seen wherein PRP treatments are combined with hair restoration surgeries. Furthermore, the PRP activation protocol in the hair restoration setting employs compounds with potentially deleterious side effects, namely thrombin or calcium gluconate...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29270413/cd133-mrna-may-be-a-suitable-prognostic-marker-for-human-breast-cancer
#20
EDITORIAL
Pu Xia
Breast cancer is the most commonly malignant cancers in women. CD133 protein is a widely used marker for isolating cancer stem cell (CSC). Its expression is associated with the prognosis of many cancers. However, whether CD133 mRNA could be used as an independent prognostic factor for breast cancer remains inconsistent in previous studies. In this study, I used the Gene Expression-Based Outcome for Breast Cancer Online algorithm (GOBO) software to analysis the prognostic roles of CD133 mRNA in the subtypes of breast cancer...
2017: Stem Cell Investigation
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