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Stem Cell Investigation

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https://www.readbyqxmd.com/read/28217710/shedding-light-on-the-darc-knight-as-a-guardian-of-hematopoietic-stem-cell-quiescence
#1
COMMENT
Pniel Nham, Jae-Il Choi, Jin Hur, Sung Hee Baek, Hyo-Soo Kim
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217709/redox-homeostasis-unlocking-the-bottleneck-in-glia-to-neuron-conversion
#2
EDITORIAL
Friederike Klempin, Karen Gertz, Golo Kronenberg
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217708/aberrant-rna-splicing-and-mutations-in-spliceosome-complex-in-acute-myeloid-leukemia
#3
COMMENT
Jianbiao Zhou, Wee-Joo Chng
The spliceosome, the cellular splicing machinery, regulates RNA splicing of messenger RNA precursors (pre-mRNAs) into maturation of protein coding RNAs. Recurrent mutations and copy number changes in genes encoding spliceosomal proteins and splicing regulatory factors have tumor promoting or suppressive functions in hematological malignancies, as well as some other cancers. Leukemia stem cell (LSC) populations, although rare, are essential contributors of treatment failure and relapse. Recent researches have provided the compelling evidence that link the erratic spicing activity to the LSC phenotype in acute myeloid leukemia (AML)...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217707/microrna-regulation-of-human-pancreatic-cancer-stem-cells
#4
REVIEW
Yi-Fan Xu, Bethany N Hannafon, Wei-Qun Ding
microRNAs (miRNAs) are a group of small non-coding RNAs that function primarily in the post transcriptional regulation of gene expression in plants and animals. Deregulation of miRNA expression in cancer cells, including pancreatic cancer cells, is well documented, and the involvement of miRNAs in orchestrating tumor genesis and cancer progression has been recognized. This review focuses on recent reports demonstrating that miRNAs are involved in regulation of pancreatic cancer stem cells (CSCs). A number of miRNA species have been identified to be involved in regulating pancreatic CSCs, including miR-21, miR-34, miR-1246, miR-221, the miR-17-92 cluster, the miR-200 and let-7 families...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217706/there-will-be-blood-hematopoiesis-control-by-mediator-subunit-med12
#5
COMMENT
Thomas G Boyer
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217705/med12-in-hematopoietic-stem-cells-cell-specific-function-despite-ubiquitous-expression
#6
EDITORIAL
Maria-Cristina Keightley, Susan K Nilsson, Graham J Lieschke
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217704/role-of-adventitial-msc-like-cells-in-chronic-kidney-disease
#7
EDITORIAL
Benedetta Bussolati, Maria Chiara Deregibus, Giovanni Camussi
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28217703/babesiosis-associated-immune-thrombocytopenia
#8
Roshni Narurkar, Aleksandra Mamorska-Dyga, Anup Agarwal, John C Nelson, Delong Liu
Thrombocytopenia is a common feature of babesiosis. The mechanism for thrombocytopenia in babesiosis remains elusive. We report a case of babesiosis with severe new onset immune thrombocytopenia (ITP). In addition to antibiotics treatment for babesiosis, ITP therapy was administered. ITP in the present case was most likely triggered by the babesia infection. The severity of ITP in this case was not proportional to the severity of parasitemia. The neoantigen triggering the autoimmune response in babesiosis requires further characterization...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078276/increased-vulnerability-of-photoreceptors-to-aberrant-splicing-highlight-the-utility-of-aon-based-therapy-for-cep290-lca
#9
COMMENT
Shannon E Boye
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078275/peptide-vaccination-against-multiple-myeloma-using-peptides-derived-from-anti-apoptotic-proteins-a-phase-i-trial
#10
Nicolai Grønne Jørgensen, Shamaila Munir Ahmad, Niels Abildgaard, Per Thor Straten, Inge Marie Svane, Mads Hald Andersen, Lene Meldgaard Knudsen
The B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the disease. This makes the Bcl-2 proteins interesting targets for therapeutic peptide vaccination. We report a phase I trial of therapeutic vaccination with peptides from the proteins Bcl-2, Bcl-XL and Mcl-1 in patients with relapsed MM. Vaccines were given concomitant with bortezomib. Out of 7 enrolled patients, 4 received the full course of 8 vaccinations...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078274/outside-the-brain-an-inside-view-on-transgenic-animal-and-stem-cell-based-models-to-examine-neuronal-serotonin-dependent-regulation-of-hpa-axis-controlled-events-during-development-and-adult-stages
#11
COMMENT
Jonas Waider, Janina Ziegler, Thorsten Lau
Recently, Trista North and colleagues showed that neuronal synthesis of serotonin is an essential key process for embryonic hematopoietic stem (HPS) cell production in zebrafish. Using their experimental design, they were able to show that neuronal serotonin activates the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor activity which in turn induces HPS cell formation. In our perspective, we give a short overview on established experimental approaches for serotonergic neurotransmission in vivo and in vitro and their potential to address putative contributions of serotonergic neurotransmission to physiological processes beyond the central nervous systems (CNS)...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078273/combining-retinoic-acid-and-oral-arsenic-may-be-potentially-the-first-line-therapy-for-non-high-risk-acute-promyelocytic-leukemia
#12
COMMENT
Lin Fu, Jinlong Shi, Jia Liu, Anqi Liu, Kailin Xu, Xiaoyan Ke
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078272/novel-methods-for-the-treatment-of-liver-fibrosis-using-in-vivo-direct-reprogramming-technology
#13
COMMENT
Takeshi Goya, Atsushi Suzuki
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078271/cell-sources-for-regenerative-medicine-of-the-liver-and-endoderm-organs-strategies-and-perspectives
#14
EDITORIAL
Guido Carpino, Eugenio Gaudio
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078270/wilms-tumor-1-peptide-vaccination-after-hematopoietic-stem-cell-transplant-in-leukemia-patients
#15
REVIEW
Naoki Hosen, Tetsuo Maeda, Yoshiko Hashii, Akihiro Tsuboi, Sumiyuki Nishida, Jun Nakata, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama
Although the prognosis of leukemia patients after allogeneic hematopoietic stem cell transplantation (HSCT) has greatly improved, relapse is still a major cause of death after HSCT. Cancer vaccines may have the potential to enhance the graft-versus-leukemia (GVL) effect. The post-allogeneic HSCT period provides a unique platform for vaccination, because (I) tumor burden is minimal, (II) lymphopenia allows for rapid expansion of cytotoxic T cells (CTLs), (III) donor-derived CTLs are not exhausted, (IV) inflammation is caused by alloreactions, and (V) the abundance of regulatory T cells is low due to their late recovery...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078269/comment-on-expandable-cardiovascular-progenitor-cells-reprogrammed-from-fibroblasts
#16
EDITORIAL
Hiroyuki Yamakawa, Keiichi Fukuda
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078268/blocking-tgf-%C3%AE-and-bmp-smad-dependent-cell-differentiation-is-a-master-key-to-expand-all-kinds-of-epithelial-stem-cells
#17
COMMENT
Boris Guyot, Véronique Maguer-Satta
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066789/bone-marrow-derived-stem-cell-therapy-for-type-2-diabetes-mellitus
#18
Tarek Wehbe, Nassim Abi Chahine, Salam Sissi, Isabelle Abou-Joaude, Louis Chalhoub
In this study, 6 patients with type 2 diabetes (T2D) underwent autologous bone marrow mononuclear stem cell (BM-MNSC) infusion into the celiac and superior mesenteric arteries without pretreatment with any myeloablative or immune-suppressive therapy. Five of 6 (83%) showed normalization of their fasting glucose and the glycosylated hemoglobin (HbA1C) with significant reduction of their medication requirements. The HbA1C dropped on average 2.2 points. The three patients with diabetic complications showed improvement or stabilization and most patients reported improved energy and stamina...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066788/the-silver-lining-of-induced-pluripotent-stem-cell-variation
#19
COMMENT
Valentina Fossati, Tanya Jain, Ana Sevilla
Induced pluripotent stem cells (iPSCs) are being generated using various reprogramming methods and from different cell sources. Hence, a lot of effort has been devoted to evaluating the differences among iPSC lines, in particular with respect to their differentiation capacity. While line-to-line variability should mainly reflect the genetic diversity within the human population, here we review some studies that have brought attention to additional variation caused by genomic and epigenomic alterations. We discuss strategies to evaluate aberrant changes and to minimize technical and culture-induced noise, in order to generate safe cells for clinical applications...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066787/bcr-abl-can-promote-cd19-cell-growth-but-not-render-them-long-term-stemness
#20
Donghe Li, Xuemei Zhao, Ruihong Zhang, Bo Jiao, Ping Liu, Ruibao Ren
BACKGROUND: Cancer stem cells are a subpopulation of malignant cells that have the capacity of both self-renewal and reconstitution of the cancer. Eradication of cancer stem cells is crucial for curing the malignant disease. Previous studies in hematopoietic malignancies showed that leukemia stem cells (LSCs) in chronic myelogenous leukemia (CML) chronic phase are originated from a hematopoietic stem cell (HSC), while LSCs in acute myeloid leukemia (AML) can either be derived from HSCs or be transformed from myeloid progenitors...
2016: Stem Cell Investigation
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