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Stem Cell Investigation

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https://www.readbyqxmd.com/read/30050919/temporary-storage-solution-for-adipose-derived-mesenchymal-stem-cells
#1
Chyara Elisa Nofianti, Intan Novita Sari, Marlina, Novialdi, Jeanne Adiwinata Pawitan
Background: We have developed a simple lipoaspirate washing method using a coffee filter to eliminate liposuction noxious material before isolating adipose tissue derived mesenchymal stem cells (AT-MSCs), and used them in clinical trials. Before administration to patients, MSCs are usually suspended in physiologic saline. However, MSCs only survive for a limited time in physiologic saline. Therefore, alternative solution that can preserve MSC survival will be beneficial. Therefore, the purpose of this study was to compare the use of physiologic saline and Dulbecco's modified Eagle's Medium (DMEM) as temporary storage solution for our AT-MSCs...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/30050918/stem-cell-ophthalmology-treatment-study-bone-marrow-derived-stem-cells-in-the-treatment-of-retinitis-pigmentosa
#2
Jeffrey N Weiss, Steven Levy
Background: Seventeen patients with bilateral visual loss due to Retinitis Pigmentosa (RP) underwent autologous bone marrow derived stem cell (BMSC) treatment within the Stem Cell Ophthalmology Treatment Study (SCOTS and SCOTS 2). Both are National Institutes of Health (NIH) and Office of Human Research Protection (OHRP) compliant Institutional Review Board (IRB) approved clinical studies utilizing using autologous BMSC in the treatment of retinal and optic nerve diseases that meet inclusion criteria...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29984226/the-ved-protein-patterning-in-zebrafish-embryos
#3
EDITORIAL
Elena S Pshennikova, Anna S Voronina
Homeobox transcription factors play an essential role in cells differentiation. The function is realized by the proteins (not by the mRNA) and it is necessary to pay more attention to the protein patterns. In this study we were the first to obtain antibodies against the ved protein, tested their specificity by Western-blot analysis and performed a whole mount immunostaining of zebrafish embryos. It was shown that the spatial-temporal ved protein pattern did not differ from that of other vent-family factors...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29984225/cell-intrinsic-regulation-of-external-hematopoietic-stem-cell-stress
#4
EDITORIAL
Frank J T Staal
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29984224/retraction-engineering-of-extracellular-vesicles-as-drug-delivery-vehicles
#5
Sung-Man Kim, Han-Soo Kim
[This retracts the article DOI: 10.21037/sci.2017.08.07.].
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29984223/retraction-into-the-eyes-of-bone-marrow-derived-mesenchymal-stem-cells-therapy-for-myocardial-infarction-and-other-diseases
#6
Jian-Rui Li, Ting-Ting Qu
[This retracts the article DOI: 10.21037/sci.2017.08.01.].
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29782583/evolutionarily-diverse-mechanisms-of-germline-specification-among-mammals-what-about-us
#7
EDITORIAL
Shino Mitsunaga, Toshi Shioda
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29782571/epigenomic-and-single-cell-profiling-of-human-spermatogonial-stem-cells
#8
EDITORIAL
Akihiko Sakashita, Yu-Han V Yeh, Satoshi H Namekawa, Shau-Ping Lin
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29782557/signals-and-transcription-factors-for-specification-of-human-germ-cells
#9
EDITORIAL
Sina Jostes, Hubert Schorle
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29780814/targeting-chronic-myeloid-leukemia-stem-cells-can-transcriptional-program-be-a-druggable-target-for-cancers
#10
REVIEW
Yosuke Masamoto, Mineo Kurokawa
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm resulting from acquisition of constitutively active BCR-ABL protein tyrosine kinase in a hematopoietic stem cell (HSC). Though tyrosine kinase inhibitors (TKIs) have changed a fatal disease into manageable disease, most patients cannot discontinue TKI treatment due to persistence of TKI-resistant leukemia stem cells (LSCs). Much effort has been made to find out factors or pathways specifically operating in LSCs to selectively target LSCs, with some promising results at least in preclinical models...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29780813/loss-of-heterogeneity-quiescence-and-differentiation-in-muscle-stem-cells
#11
REVIEW
Haser Hasan Sutcu, Miria Ricchetti
Skeletal muscle stem cells in the adult display heterogeneity that has been functionally linked to their behavior, self-renewal capacity, and resistance to stress in hostile environments. Behavioral heterogeneity emerges also during developmental myogenesis. Muscle stem cell diversity may be functionally linked to the changing needs of skeletal muscle regeneration. Intriguingly, dramatic reduction of stem cell diversity, the "clonal drift", that implies loss of stem cells and related expansion of clonally related stem cells has been reported for tissue replacement in several adult tissues and suggested in the zebrafish embryo...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29682515/the-puzzling-mechanism-of-compensatory-lung-growth
#12
EDITORIAL
Steven J Mentzer
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29682514/cutaneous-metastases-of-breast-cancer-during-adjuvant-chemotherapy-correlates-with-increasing-cd44-cd24-and-aldh-1-expression-a-case-report-and-literature-review
#13
Jung Sun Lee, Woo Gyeong Kim
Cancer stem cells (CSCs) within a tumor are scarce and self-sustaining and they have the abilities for self-renewal and the potential of giving rise to diverse types of cells that compose the tumor. These cells are suggested to be associated with therapeutic failure, and therefore they remain as an important issue in this regard. We report the cases of two breast cancer patients diagnosed with rapid cutaneous metastases during adjuvant cytotoxic chemotherapy after curative mastectomy. For elucidating a relationship between CSCs and resistance to chemotherapy, we evaluated primary tumor and metastatic cutaneous lesions by CSC markers in immunohistochemical stains (CD44+ /CD24- and ALDH-1)...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29682513/lung-cancer-stem-cells-origin-characteristics-and-therapy
#14
REVIEW
D Prabavathy, Y Swarnalatha, Niveditha Ramadoss
Cancer stem cells (CSCs) have gained an increasing attention recently in cancer research. CSCs have ability to generate new tumor through their stem cell properties, essentially self-renewal potential and differentiation into multiple cell lineages. Extensive evidences report that CSCs are resistant to many conventional therapies and mediate tumor recurrence. CSCs of lung cancer are well recognized by their specific markers such as CD133, CD44, ABCG2 and ALDH1A1 together with the CSC characteristics including spheroid and colony formation...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29682512/targeting-notch-signalling-pathway-of-cancer-stem-cells
#15
REVIEW
Vandana Venkatesh, Raghu Nataraj, Gopenath S Thangaraj, Murugesan Karthikeyan, Ashok Gnanasekaran, Shanmukhappa B Kaginelli, Gobianand Kuppanna, Chandrashekrappa Gowdru Kallappa, Kanthesh M Basalingappa
Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies. CSCs have slow growth rate and are resistant to chemotherapy and radiotherapy that lead to the failure of traditional current therapy. Eradicating the CSCs and recurrence, is promising aspect for the cure of cancer...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430460/cancer-stem-cells-and-evolving-novel-therapies-a-paradigm-shift
#16
REVIEW
Sangeetha Vasudevaraj Naveen, Kumar Kalaivani
Accumulating evidence of stem-like cells/cancer stem cells (CSCs) has been gaining attention of cancer researchers over the last decade. Though many tumors harbor CSCs in their dedicated niches, identifying and exterminating those cells has proved to be difficult, due to their heterogenous nature, as the CSC phenotype vary substantially and may undergo reversible phenotypic changes. As a tumor propagation initiator, CSCs are considered as an exciting novel therapy for a better therapeutic outcome. This review discusses the major advances in the development of CSC-based therapies of most common cancers which includes lung, cervix and liver cancers...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430459/organoids-recapitulate-organs
#17
EDITORIAL
Tohru Sugawara, Kengo Sasaki, Hidenori Akutsu
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430458/integrin-%C3%AE-7-a-novel-promising-target-in-glioblastoma-stem-cells
#18
EDITORIAL
Estefania Carrasco-Garcia, Jaione Auzmendi-Iriarte, Ander Matheu
No abstract text is available yet for this article.
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29430457/evaluating-the-behavior-of-cultured-sertoli-cells-in-the-presence-and-absence-of-spermatogonial-stem-cell
#19
Masoome Jabarpour, Parviz Tajik
Background: The complex process of spermatogenesis is regulated by various factors. Several studies have been conducted to proliferate cells involved in the spermatogenesis process, in culture by used growth factors, different hormones and feeder cells. This study was conducted to evaluate the role of Sertoli cells on gene expression of fibroblast growth factor ( FGF2 ) and glial cell derived neurotrophic factor ( GDNF ) after removal of spermatogonial stem cells (SSCs) from the culture medium...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29359141/extracellular-vesicles-and-cardiovascular-disease-therapy
#20
REVIEW
Jérémy Amosse, Maria Carmen Martinez, Soazig Le Lay
Cardiovascular disease (CVD) constitutes one of the leading causes of mortality worldwide, therefore representing a major public health concern. Despite recent advances in the treatment of patients with acute myocardial infarction (AMI), such as bypass surgery or percutaneous coronary intervention, pathological cardiac remodeling often predisposes survivors to fatal heart failure. In this context, the proven efficacy of stem cell-regenerative therapies constitutes a promising therapeutic perspective with is nevertheless slow down by safety and ethical concerns...
2017: Stem Cell Investigation
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