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Stem Cell Investigation

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https://www.readbyqxmd.com/read/28078276/increased-vulnerability-of-photoreceptors-to-aberrant-splicing-highlight-the-utility-of-aon-based-therapy-for-cep290-lca
#1
COMMENT
Shannon E Boye
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078275/peptide-vaccination-against-multiple-myeloma-using-peptides-derived-from-anti-apoptotic-proteins-a-phase-i-trial
#2
Nicolai Grønne Jørgensen, Shamaila Munir Ahmad, Niels Abildgaard, Per Thor Straten, Inge Marie Svane, Mads Hald Andersen, Lene Meldgaard Knudsen
The B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the disease. This makes the Bcl-2 proteins interesting targets for therapeutic peptide vaccination. We report a phase I trial of therapeutic vaccination with peptides from the proteins Bcl-2, Bcl-XL and Mcl-1 in patients with relapsed MM. Vaccines were given concomitant with bortezomib. Out of 7 enrolled patients, 4 received the full course of 8 vaccinations...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078274/outside-the-brain-an-inside-view-on-transgenic-animal-and-stem-cell-based-models-to-examine-neuronal-serotonin-dependent-regulation-of-hpa-axis-controlled-events-during-development-and-adult-stages
#3
COMMENT
Jonas Waider, Janina Ziegler, Thorsten Lau
Recently, Trista North and colleagues showed that neuronal synthesis of serotonin is an essential key process for embryonic hematopoietic stem (HPS) cell production in zebrafish. Using their experimental design, they were able to show that neuronal serotonin activates the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor activity which in turn induces HPS cell formation. In our perspective, we give a short overview on established experimental approaches for serotonergic neurotransmission in vivo and in vitro and their potential to address putative contributions of serotonergic neurotransmission to physiological processes beyond the central nervous systems (CNS)...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078273/combining-retinoic-acid-and-oral-arsenic-may-be-potentially-the-first-line-therapy-for-non-high-risk-acute-promyelocytic-leukemia
#4
COMMENT
Lin Fu, Jinlong Shi, Jia Liu, Anqi Liu, Kailin Xu, Xiaoyan Ke
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078272/novel-methods-for-the-treatment-of-liver-fibrosis-using-in-vivo-direct-reprogramming-technology
#5
COMMENT
Takeshi Goya, Atsushi Suzuki
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078271/cell-sources-for-regenerative-medicine-of-the-liver-and-endoderm-organs-strategies-and-perspectives
#6
EDITORIAL
Guido Carpino, Eugenio Gaudio
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078270/wilms-tumor-1-peptide-vaccination-after-hematopoietic-stem-cell-transplant-in-leukemia-patients
#7
REVIEW
Naoki Hosen, Tetsuo Maeda, Yoshiko Hashii, Akihiro Tsuboi, Sumiyuki Nishida, Jun Nakata, Yusuke Oji, Yoshihiro Oka, Haruo Sugiyama
Although the prognosis of leukemia patients after allogeneic hematopoietic stem cell transplantation (HSCT) has greatly improved, relapse is still a major cause of death after HSCT. Cancer vaccines may have the potential to enhance the graft-versus-leukemia (GVL) effect. The post-allogeneic HSCT period provides a unique platform for vaccination, because (I) tumor burden is minimal, (II) lymphopenia allows for rapid expansion of cytotoxic T cells (CTLs), (III) donor-derived CTLs are not exhausted, (IV) inflammation is caused by alloreactions, and (V) the abundance of regulatory T cells is low due to their late recovery...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078269/comment-on-expandable-cardiovascular-progenitor-cells-reprogrammed-from-fibroblasts
#8
EDITORIAL
Hiroyuki Yamakawa, Keiichi Fukuda
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28078268/blocking-tgf-%C3%AE-and-bmp-smad-dependent-cell-differentiation-is-a-master-key-to-expand-all-kinds-of-epithelial-stem-cells
#9
COMMENT
Boris Guyot, Véronique Maguer-Satta
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066789/bone-marrow-derived-stem-cell-therapy-for-type-2-diabetes-mellitus
#10
Tarek Wehbe, Nassim Abi Chahine, Salam Sissi, Isabelle Abou-Joaude, Louis Chalhoub
In this study, 6 patients with type 2 diabetes (T2D) underwent autologous bone marrow mononuclear stem cell (BM-MNSC) infusion into the celiac and superior mesenteric arteries without pretreatment with any myeloablative or immune-suppressive therapy. Five of 6 (83%) showed normalization of their fasting glucose and the glycosylated hemoglobin (HbA1C) with significant reduction of their medication requirements. The HbA1C dropped on average 2.2 points. The three patients with diabetic complications showed improvement or stabilization and most patients reported improved energy and stamina...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066788/the-silver-lining-of-induced-pluripotent-stem-cell-variation
#11
COMMENT
Valentina Fossati, Tanya Jain, Ana Sevilla
Induced pluripotent stem cells (iPSCs) are being generated using various reprogramming methods and from different cell sources. Hence, a lot of effort has been devoted to evaluating the differences among iPSC lines, in particular with respect to their differentiation capacity. While line-to-line variability should mainly reflect the genetic diversity within the human population, here we review some studies that have brought attention to additional variation caused by genomic and epigenomic alterations. We discuss strategies to evaluate aberrant changes and to minimize technical and culture-induced noise, in order to generate safe cells for clinical applications...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066787/bcr-abl-can-promote-cd19-cell-growth-but-not-render-them-long-term-stemness
#12
Donghe Li, Xuemei Zhao, Ruihong Zhang, Bo Jiao, Ping Liu, Ruibao Ren
BACKGROUND: Cancer stem cells are a subpopulation of malignant cells that have the capacity of both self-renewal and reconstitution of the cancer. Eradication of cancer stem cells is crucial for curing the malignant disease. Previous studies in hematopoietic malignancies showed that leukemia stem cells (LSCs) in chronic myelogenous leukemia (CML) chronic phase are originated from a hematopoietic stem cell (HSC), while LSCs in acute myeloid leukemia (AML) can either be derived from HSCs or be transformed from myeloid progenitors...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066786/hypomethylating-agents-after-allogeneic-blood-stem-cell-transplantation
#13
REVIEW
Thomas Schroeder, Christina Rautenberg, Rainer Haas, Guido Kobbe
Allogeneic blood stem cell transplantation (allo-SCT) is a potentially curative treatment for patients with myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), but relapse remains the major cause of treatment failure. So far, therapeutic options for patients with AML or MDS who relapse after allo-SCT generally consisted of palliative care, low-dose or intensive chemotherapy as well as cellular therapies such as donor lymphocyte infusions (DLI) and second transplantation in selected cases...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066785/enrichment-of-skin-derived-neural-precursor-cells-from-dermal-cell-populations-by-altering-culture-conditions
#14
Vahid Bayati, Rohoullah Gazor, Reza Nejatbakhsh, Fereshteh Negad Dehbashi
BACKGROUND: As stem cells play a critical role in tissue repair, their manipulation for being applied in regenerative medicine is of great importance. Skin-derived precursors (SKPs) may be good candidates for use in cell-based therapy as the only neural stem cells which can be isolated from an accessible tissue, skin. Herein, we presented a simple protocol to enrich neural SKPs by monolayer adherent cultivation to prove the efficacy of this method. METHODS: To enrich neural SKPs from dermal cell populations, we have found that a monolayer adherent cultivation helps to increase the numbers of neural precursor cells...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066784/harnessing-tgf-%C3%AE-and-bmp-signaling-for-expansion-of-p63-positive-epithelial-stem-cells
#15
EDITORIAL
Steven L Brody, Gerard E Kaiko
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066783/editing-genetics-stem-cells-are-prophetic-what-s-the-best-way-to-model-cells-of-diabetics
#16
COMMENT
Marissa A Scavuzzo, Malgorzata Borowiak
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066782/studying-pancreas-development-and-diabetes-using-human-pluripotent-stem-cells
#17
EDITORIAL
David W Scoville, Anton M Jetten
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066781/the-vox-mrna-and-protein-expression-in-zebrafish-pou5f3-mzspg-mutant-embryos
#18
Anna Voronina, Elena Pshennikova
The transcription factor of pluripotency Pou5f3 is considered to enhance the Vox expression. This conclusion was based on the study of mRNA expression, but the expression of the Vent-family proteins was not analyzed. We compare spatiotemporal distribution of the Vox and Vent mRNAs and the proteins in embryos of wild type zebrafish (WT) and MZspg (spiel ohne grenzen) mutants devoid of both maternal and embryonic Pou5f3 functions. We revealed the Vox mRNA and its protein in both the WT and mutant embryos during the cleavage period...
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066780/efficient-crispr-cas9-based-gene-correction-in-induced-pluripotent-stem-cells-established-from-fibroblasts-of-patients-with-sickle-cell-disease
#19
EDITORIAL
Masahiro Sato, Issei Saitoh, Emi Inada
No abstract text is available yet for this article.
2016: Stem Cell Investigation
https://www.readbyqxmd.com/read/28066779/e-cadherin-adhesion-mediated-wnt-activation-for-mesoderm-specification-in-human-embryonic-stem-cells-needs-a-soft-mattress
#20
COMMENT
Andrew Sulaiman, Li Li, Lisheng Wang
No abstract text is available yet for this article.
2016: Stem Cell Investigation
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