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Stem Cell Investigation

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https://www.readbyqxmd.com/read/29167807/nicotinamide-a-novel-treatment-for-age-related-macular-degeneration
#1
EDITORIAL
Peter D Westenskow
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29167806/aplastic-anemia-is-related-to-alterations-in-t-cell-receptor-signaling
#2
REVIEW
Yankai Xiao, Suwen Zhao, Bo Li
Aplastic anemia (AA) is a disease characterized by bone marrow hematopoietic dysfunction and peripheral blood pancytopenia, which is thought to be mediated by an abnormal T cell-induced immune response. T cell receptor (TCR) signaling is pivotal for T cell development and function. An aberrant TCR signaling leads to an unbalanced immune system that can result in a range of immune-related disorders, including autoimmune diseases, chronic infections, and tumors. In this article, we briefly review the T cell immune pathophysiology of AA, the physiology of normal TCR signaling and its regulatory factors, and clinical and laboratory findings of TCR signaling molecules and their regulatory factors in AA...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29167805/clinical-potential-of-mesenchymal-stem-stromal-cell-derived-extracellular-vesicles
#3
REVIEW
Bernd Giebel, Lambros Kordelas, Verena Börger
Within the last two decades mesenchymal stem/stromal cells (MSCs) emerged after hematopoietic stem cells as the second most investigated and applied somatic stem cell entity so far. MSCs mediate immunosuppressive as well as pro-regenerative activities. Against the initial assumption, MSCs may not primarily exert their therapeutic functions in a cellular but rather in a paracrine manner. Here, extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as major mediators of these paracrine effects...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29167804/extracellular-vesicle-mediated-transport-of-non-coding-rnas-between-stem-cells-and-cancer-cells-implications-in-tumor-progression-and-therapeutic-resistance
#4
REVIEW
Muhammad Nawaz
Recent years have witnessed intensive progress in studying extracellular vesicles (EVs), both for understanding their basic biology and contribution to variety of diseases, biomarker discovery, and their potential as gene delivery vectors and source of innovative therapies. As such, stem cell-derived EVs have contributed significant knowledge which led to the development of cell-free therapies in regenerative medicine. Although, the role of stem cell-derived EVs in maintaining stemness, differentiation and repairing tissue injuries is relatively well-understood; however, knowledge about the contribution of stem cell-derived EVs in cancer progression is just emerging...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29167803/there-and-back-again-amitosis-to-repopulate-a-stem-cell-pool
#5
EDITORIAL
Fanju W Meng, Benoît Biteau
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057253/nicotinamide-irpe-in-a-dish-and-age-related-macular-degeneration-therapy-development
#6
EDITORIAL
Arthur A Bergen
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057252/glis1-3-emerging-roles-in-reprogramming-stem-and-progenitor-cell-differentiation-and-maintenance
#7
REVIEW
David W Scoville, Hong Soon Kang, Anton M Jetten
Recent studies have provided evidence for a regulatory role of GLI-similar (GLIS) transcription factors in reprogramming, maintenance and differentiation of several stem and progenitor cell populations. GLIS1, in conjunction with several other reprogramming factors, was shown to markedly increase the efficiency of generating induced pluripotent stem cells (iPSC) from somatic cells. GLIS2 has been reported to contribute to the maintenance of the pluripotent state in hPSCs. In addition, GLIS2 has a function in regulating self-renewal of hematopoietic progenitors and megakaryocytic differentiation...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057251/the-rna-helicase-ddx5-is-a-reprogramming-roadblock
#8
EDITORIAL
Cyril F Bourgeois, Didier Auboeuf
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057250/stem-cell-extracellular-vesicles-and-lung-repair
#9
REVIEW
Fernanda F Cruz, Patricia R M Rocco
Four out of the ten leading causes of morbidity and mortality worldwide are lung diseases. Despite advances in comprehending the pathophysiological mechanisms involved in these disorders, for several respiratory diseases, there is still no effective treatment able to stop their natural history or reverse the morphological and functional damage they cause. In this context, recent research has supported a potential role of cell therapy for lung diseases and critical illness. The anti-inflammatory, antifibrotic, and microbicidal effects of stem cells are mainly attributed to their secretome, which contains proteins, lipids, microRNAs, and mRNAs...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057249/indoleamine-2-3-dioxygenase-and-survivin-peptide-vaccine-combined-with-temozolomide-in-metastatic-melanoma
#10
Nikolaj Juul Nitschke, Jon Bjoern, Trine Zeeberg Iversen, Mads Hald Andersen, Inge Marie Svane
BACKGROUND: Indoleamine 2,3-dioxygenase (IDO) and survivin have been identified as potential targets for cancer vaccination. In this phase II study a vaccine using the peptides Sur1M2 and IDO5 was combined with the chemotherapy temozolomide (TMZ) for treatment of metastatic melanoma patients. The aim was to simultaneously target several immune inhibiting mechanisms and the highly malignant cells expressing survivin. METHODS: HLA-A2 positive patients with advanced malignant melanoma were treated biweekly with 150 mg/m(2) TMZ daily for 7 days followed by subcutaneous vaccination with 250 µg of each peptide in 500 µL Montanide solution at day 8...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057248/cell-lineage-specification-at-single-cell-resolution
#11
COMMENT
Jian Yang, Pentao Liu
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057247/extracellular-vesicles-as-regulators-of-tumor-fate-crosstalk-among-cancer-stem-cells-tumor-cells-and-mesenchymal-stem-cells
#12
REVIEW
Rafael Soares Lindoso, Federica Collino, Adalberto Vieyra
The tumor microenvironment comprises a heterogeneous population of tumorigenic and non-tumorigenic cells. Cancer stem cells (CSCs) and mesenchymal stem cells (MSCs) are components of this microenvironment and have been described as key regulators of different aspects of tumor physiology. They act differently on the tumor: CSCs are described as tumor initiators and are associated with tumor growth, drug resistance and metastasis; MSCs can integrate the tumor microenvironment after recruitment and interact with cancer cells to promote tumor modifications...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057246/engineering-of-extracellular-vesicles-as-drug-delivery-vehicles
#13
REVIEW
Sung-Man Kim, Han-Soo Kim
Extracellular vesicles (EVs) are secreted membrane-enclosed nano-sized particles (40-1,000 nm) that deliver biological information between cells. The molecular composition of these subcellular particles includes growth factor receptors, ligands adhesion proteins, mRNA, miRNAs, lncRNA and lipids that are derived from donor cells. A number of studies demonstrated that stem cell-derived EVs are the key mediator of tissue repair and regeneration in multiple animal disease models. In addition, the composition of these particles is known to be altered in cancer and disease pathology suggesting them for useful in diagnostic and therapeutic purposes...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057245/a-case-report-of-congenital-glycogen-storage-liver-cirrhosis-treated-with-bone-marrow-derived-stem-cells
#14
Terek W Wehbe, Nassim H Abi Chahine, Abdul-Rahman A Annous, Mohammad A Ferri, Robert C Boulous, Majid F El-Mestrah
Liver cirrhosis represents a state of end-stage failure that is usually fatal. The condition results in liver dysfunction, recurrent ascites, encephalopathy, renal failure, splenomegaly, bleeding, and a poor quality of life in general. With the current severe shortage of donated organs, the only available treatment in the developing countries remains palliative care. We report a case of congenital metabolic liver cirrhosis due to glycogen storage disease diagnosed at age eight. The patient, a male, received bone marrow derived mononuclear cells (BMMC) at age 16 and again at age 17 with significant improvement of his biochemical liver function tests, ascites build-up, asthenia, splenomegaly and quality of life...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29057244/pdgfa-regulation-of-dermal-adipocyte-stem-cells
#15
COMMENT
Guillermo C Rivera-Gonzalez, Brett A Shook, Valerie Horsley
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28920064/cone-fusion-confusion-in-photoreceptor-transplantation
#16
EDITORIAL
Robert E MacLaren
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28920063/hesc-derived-photoreceptors-survive-and-integrate-better-in-immunodeficient-retina
#17
EDITORIAL
Magdalene J Seiler
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28920062/into-the-eyes-of-bone-marrow-derived-mesenchymal-stem-cells-therapy-for-myocardial-infarction-and-other-diseases
#18
REVIEW
Jian-Rui Li, Ting-Ting Qu
Applications of bone marrow-derived mesenchymal stem cells (BM-MSCs) have been documented for diseases occur in the sports system, the central nervous system, the cardiovascular system etc. However, poor viability of donor stem cells after transplantation limits their therapeutic efficiency. Although the autophagy theory has been reported, the underlying mechanisms are still poorly understood. Isolation and culture methods of mesenchymal stem cells are currently concentrate on four ways. Overall, BM-MSCs have both important research significance and clinical application value in cell replacement therapy, gene therapy and reconstruction of tissues as well as organs especially for myocardial infarction (MI)...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28920061/biological-and-clinical-insights-offered-by-chemically-induced-liver-progenitors-clips
#19
COMMENT
Takeshi Katsuda, Takahiro Ochiya
No abstract text is available yet for this article.
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28815178/stem-cell-manipulation-gene-therapy-and-the-risk-of-cancer-stem-cell-emergence
#20
REVIEW
Flora Clément, Elodie Grockowiak, Florence Zylbersztejn, Gaëlle Fossard, Stéphanie Gobert, Véronique Maguer-Satta
Stem cells (SCs) have been extensively studied in the context of regenerative medicine. Human hematopoietic stem cell (HSC)-based therapies have been applied to treat leukemic patients for decades. Handling of mesenchymal stem cells (MSCs) has also raised hopes and concerns in the field of tissue engineering. Lately, discovery of cell reprogramming by Yamanaka's team has profoundly modified research strategies and approaches in this domain. As we gain further insight into cell fate mechanisms and identification of key actors and parameters, this also raises issues as to the manipulation of SCs...
2017: Stem Cell Investigation
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