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JAMA Cardiology

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https://www.readbyqxmd.com/read/29710189/aortic-valve-surgery-after-recent-stroke-patience-is-a-virtue
#1
Michael T Mullen, Steven R Messé
No abstract text is available yet for this article.
April 25, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710128/association-of-timing-of-aortic-valve-replacement-surgery-after-stroke-with-risk-of-recurrent-stroke-and-mortality
#2
Charlotte Andreasen, Mads Emil Jørgensen, Gunnar H Gislason, Andreas Martinsson, Robert D Sanders, Jawdat Abdulla, Per Føge Jensen, Christian Torp-Pedersen, Lars Køber, Charlotte Andersson
Importance: Timing of surgical aortic valve replacement (SAVR) in patients with aortic valve stenosis and previous stroke for the risk of recurrent stroke is insufficiently investigated. Objective: To evaluate the association of time elapsed between previous stroke and SAVR with the risk of recurrent perioperative stroke, major adverse cardiovascular events (MACE), and mortality among patients with aortic valve stenosis. Design, Setting, and Participants: This cohort study using data from Danish administrative registries included all patients with aortic valve stenosis older than 18 years who underwent SAVR between 1996 and 2014 (n = 14 030)...
April 25, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710336/association-of-fibroblast-growth-factor-23-with-recurrent-cardiovascular-events-in-patients-after-an-acute-coronary-syndrome-a-secondary-analysis-of-a-randomized-clinical-trial
#3
Brian A Bergmark, Jacob A Udell, David A Morrow, Christopher P Cannon, Dylan L Steen, Petr Jarolim, Andrzej Budaj, Christian Hamm, Jianping Guo, KyungAh Im, Julia F Kuder, Eugene Braunwald, Marc S Sabatine, Michelle L O'Donoghue
Importance: Elevated fibroblast growth factor 23 (FGF-23) concentrations are associated with myocardial fibrosis and renin-angiotensin system upregulation, potentially providing prognostic information distinct from standard cardiovascular (CV) biomarkers. Objective: To evaluate the association of FGF-23 with recurrent CV events in patients after an acute coronary syndrome (ACS). Design, Setting, and Participants: C-terminal FGF-23 was measured in plasma samples using an established enzyme-linked immunosorbent assay system for 4947 patients within 30 days of ACS (median, 14 days) and with 1 additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) trial of the lipoprotein-associated phospholipase A2 inhibitor darapladib vs placebo performed from December 1, 2009, to April 24, 2014 (median follow-up, 2...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710297/pediatric-hypertrophy-cardiomyopathy-another-case-where-children-are-not-small-adults
#4
Elizabeth M McNally
No abstract text is available yet for this article.
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710196/long-term-outcomes-of-pediatric-onset-hypertrophic-cardiomyopathy-and-age-specific-risk-factors-for-lethal-arrhythmic-events
#5
Niccolò Maurizi, Silvia Passantino, Gaia Spaziani, Francesca Girolami, Anna Arretini, Mattia Targetti, Iva Pollini, Alessia Tomberli, Silvia Pradella, Giovanni Battista Calabri, Veronica Vinattieri, Bruno Bertaccini, Ornella Leone, Luciano De Simone, Claudio Rapezzi, Niccolò Marchionni, Franco Cecchi, Silvia Favilli, Iacopo Olivotto
Importance: Predictors of lethal arrhythmic events (LAEs) after a pediatric diagnosis of hypertrophic cardiomyopathy (HCM) are unresolved. Existing algorithms for risk stratification are limited to patients older than 16 years because of a lack of data on younger individuals. Objective: To describe the long-term outcome of pediatric-onset HCM and identify age-specific arrhythmic risk factors. Design, Setting, and Participants: This study assessed patients with pediatric-onset hypertrophic cardiomyopathy diagnosed from 1974 to 2016 in 2 national referral centers for cardiomyopathies in Florence, Italy...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710190/malignant-arrhythmia-in-a-40-year-old-man
#6
Yap-Hang Chan, Jo Jo Hai, Hung-Fat Tse
No abstract text is available yet for this article.
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29710092/evolution-of-left-ventricular-assist-device-therapy-for-advanced-heart-failure-a-review
#7
Leslie W Miller, Joseph G Rogers
Importance: The mortality rate for the most advanced forms of heart failure with medical therapy alone remains unacceptably high at 30% to 80% at 1 year. In the past decade, left ventricular assist devices have assumed an increasingly prominent role in the management of these patients. This review included all English-language articles published over the past 15 years on left ventricular assist devices. Search topics focused on advanced heart failure and ventricular assist devices, including volume of implantations, patient selection, complications, cost, and recovery of function...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641836/association-of-cardiomyopathy-with-mybpc3-d389v-and-mybpc3%C3%AE-25bpintronic-deletion-in-south-asian-descendants
#8
Shiv Kumar Viswanathan, Megan J Puckelwartz, Ashish Mehta, Chrishan J A Ramachandra, Aravindakshan Jagadeesan, Regina Fritsche-Danielson, Ratan V Bhat, Philip Wong, Sangeetha Kandoi, Jennifer A Schwanekamp, Gina Kuffel, Lorenzo L Pesce, Michael J Zilliox, U Nalla B Durai, Rama Shanker Verma, Robert E Molokie, Domodhar P Suresh, Philip R Khoury, Annie Thomas, Thriveni Sanagala, Hak Chiaw Tang, Richard C Becker, Ralph Knöll, Winston Shim, Elizabeth M McNally, Sakthivel Sadayappan
Importance: The genetic variant MYBPC3Δ25bp occurs in 4% of South Asian descendants, with an estimated 100 million carriers worldwide. MYBPC3 Δ25bp has been linked to cardiomyopathy and heart failure. However, the high prevalence of MYBPC3Δ25bp suggests that other stressors act in concert with MYBPC3Δ25bp. Objective: To determine whether there are additional genetic factors that contribute to the cardiomyopathic expression of MYBPC3Δ25bp. Design, Setting, andParticipants: South Asian individuals living in the United States were screened for MYBPC3Δ25bp, and a subgroup was clinically evaluated using electrocardiograms and echocardiograms at Loyola University, Chicago, Illinois, between January 2015 and July 2016...
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641822/maturing-methods-for-cardiovascular-disease-and-stroke-surveillance-in-the-united-states
#9
Mark D Huffman
No abstract text is available yet for this article.
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641821/geographic-variation-in-cardiovascular-disease-burden-clues-and-questions
#10
Wayne D Rosamond
No abstract text is available yet for this article.
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641820/the-burden-of-cardiovascular-diseases-among-us-states-1990-2016
#11
Gregory A Roth, Catherine O Johnson, Kalkidan Hassen Abate, Foad Abd-Allah, Muktar Ahmed, Khurshid Alam, Tahiya Alam, Nelson Alvis-Guzman, Hossein Ansari, Johan Ärnlöv, Tesfay Mehari Atey, Ashish Awasthi, Tadesse Awoke, Aleksandra Barac, Till Bärnighausen, Neeraj Bedi, Derrick Bennett, Isabela Bensenor, Sibhatu Biadgilign, Carlos Castañeda-Orjuela, Ferrán Catalá-López, Kairat Davletov, Samath Dharmaratne, Eric L Ding, Manisha Dubey, Emerito Jose Aquino Faraon, Talha Farid, Maryam S Farvid, Valery Feigin, João Fernandes, Joseph Frostad, Alemseged Gebru, Johanna M Geleijnse, Philimon Nyakauru Gona, Max Griswold, Gessessew Bugssa Hailu, Graeme J Hankey, Hamid Yimam Hassen, Rasmus Havmoeller, Simon Hay, Susan R Heckbert, Caleb Mackay Salpeter Irvine, Spencer Lewis James, Dube Jara, Amir Kasaeian, Abdur Rahman Khan, Sahil Khera, Abdullah T Khoja, Jagdish Khubchandani, Daniel Kim, Dhaval Kolte, Dharmesh Lal, Anders Larsson, Shai Linn, Paulo A Lotufo, Hassan Magdy Abd El Razek, Mohsen Mazidi, Toni Meier, Walter Mendoza, George A Mensah, Atte Meretoja, Haftay Berhane Mezgebe, Erkin Mirrakhimov, Shafiu Mohammed, Andrew Edward Moran, Grant Nguyen, Minh Nguyen, Kanyin Liane Ong, Mayowa Owolabi, Martin Pletcher, Farshad Pourmalek, Caroline A Purcell, Mostafa Qorbani, Mahfuzar Rahman, Rajesh Kumar Rai, Usha Ram, Marissa Bettay Reitsma, Andre M N Renzaho, Maria Jesus Rios-Blancas, Saeid Safiri, Joshua A Salomon, Benn Sartorius, Sadaf Ghajarieh Sepanlou, Masood Ali Shaikh, Diego Silva, Saverio Stranges, Rafael Tabarés-Seisdedos, Niguse Tadele Atnafu, J S Thakur, Roman Topor-Madry, Thomas Truelsen, E Murat Tuzcu, Stefanos Tyrovolas, Kingsley Nnanna Ukwaja, Tommi Vasankari, Vasiliy Vlassov, Stein Emil Vollset, Tolassa Wakayo, Robert Weintraub, Charles Wolfe, Abdulhalik Workicho, Gelin Xu, Simon Yadgir, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Mustafa Younis, Chuanhua Yu, Zoubida Zaidi, Maysaa El Sayed Zaki, Ben Zipkin, Ashkan Afshin, Emmanuela Gakidou, Stephen S Lim, Ali H Mokdad, Mohsen Naghavi, Theo Vos, Christopher J L Murray
Importance: Cardiovascular disease (CVD) is the leading cause of death in the United States, but regional variation within the United States is large. Comparable and consistent state-level measures of total CVD burden and risk factors have not been produced previously. Objective: To quantify and describe levels and trends of lost health due to CVD within the United States from 1990 to 2016 as well as risk factors driving these changes. Design, Setting, and Participants: Using the Global Burden of Disease methodology, cardiovascular disease mortality, nonfatal health outcomes, and associated risk factors were analyzed by age group, sex, and year from 1990 to 2016 for all residents in the United States using standardized approaches for data processing and statistical modeling...
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641819/social-worker-aided-palliative-care-intervention-in-high-risk-patients-with-heart-failure-swap-hf-a-pilot-randomized-clinical-trial
#12
Arden E O'Donnell, Kristen G Schaefer, Lynne W Stevenson, Kristen DeVoe, Kayley Walsh, Mandeep R Mehra, Akshay S Desai
Importance: Palliative care considerations are typically introduced late in the disease trajectory of patients with advanced heart failure (HF), and access to specialty-level palliative care may be limited. Objective: To determine if early initiation of goals of care conversations by a palliative care-trained social worker would improve prognostic understanding, elicit advanced care preferences, and influence care plans for high-risk patients discharged after HF hospitalization...
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29641810/management-of-ventricular-arrhythmias-and-sudden-cardiac-death-risk-related-to-ischemic-and-nonischemic-cardiomyopathy
#13
Sana M Al-Khatib, William G Stevenson
No abstract text is available yet for this article.
April 11, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29617535/association-of-methylation-signals-with-incident-coronary-heart-disease-in-an-epigenome-wide-assessment-of-circulating-tumor-necrosis-factor-%C3%AE
#14
Stella Aslibekyan, Golareh Agha, Elena Colicino, Anh N Do, Jari Lahti, Symen Ligthart, Riccardo E Marioni, Carola Marzi, Michael M Mendelson, Toshiko Tanaka, Matthias Wielscher, Devin M Absher, Luigi Ferrucci, Oscar H Franco, Christian Gieger, Harald Grallert, Dena Hernandez, Tianxiao Huan, Stella Iurato, Roby Joehanes, Allan C Just, Sonja Kunze, Honghuang Lin, Chunyu Liu, James B Meigs, Joyce B J van Meurs, Ann Zenobia Moore, Annette Peters, Holger Prokisch, Katri Räikkönen, Wolfgang Rathmann, Michael Roden, Katharina Schramm, Joel D Schwartz, John M Starr, André G Uitterlinden, Pantel Vokonas, Melanie Waldenberger, Chen Yao, Degui Zhi, Andrea A Baccarelli, Stefania Bandinelli, Ian J Deary, Abbas Dehghan, Johan Eriksson, Christian Herder, Marjo-Riitta Jarvelin, Daniel Levy, Donna K Arnett
Importance: Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with manifold consequences for mammalian pathophysiology, including cardiovascular disease. A deeper understanding of TNF-α biology may enhance treatment precision. Objective: To conduct an epigenome-wide analysis of blood-derived DNA methylation and TNF-α levels and to assess the clinical relevance of findings. Design, Setting, and Participants: This meta-analysis assessed epigenome-wide associations in circulating TNF-α concentrations from 5 cohort studies and 1 interventional trial, with replication in 3 additional cohort studies...
April 4, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29617523/effects-of-sacubitril-valsartan-on-physical-and-social-activity-limitations-in-patients-with-heart-failure-a-secondary-analysis-of-the-paradigm-hf-trial
#15
Alvin Chandra, Eldrin F Lewis, Brian L Claggett, Akshay S Desai, Milton Packer, Michael R Zile, Karl Swedberg, Jean L Rouleau, Victor C Shi, Martin P Lefkowitz, Tzvetana Katova, John J V McMurray, Scott D Solomon
Importance: Health-related quality of life (HRQL) of patients with heart failure is markedly reduced compared with that in patients with other chronic diseases, demonstrating substantial limitations in physical and social activities. In the Prospective Comparison of ARNI With an ACE-Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial, sacubitril/valsartan improved overall HRQL compared with enalapril, as determined by the Kansas City Cardiomyopathy Questionnaire (KCCQ)...
April 4, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29617522/acute-coronary-syndrome-in-a-44-year-old-woman
#16
Francisco Aguilar, Deepika Kalisetti, Sanjog Kalra
No abstract text is available yet for this article.
April 4, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29590336/importance-of-objectively-comparing-local-va-and-non-va-care-and-outcomes-serving-veterans-well
#17
William B Weeks
No abstract text is available yet for this article.
March 28, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29590308/comparing-pulmonary-arterial-wedge-pressure-and-left-ventricular-end-diastolic-pressure-for-assessment-of-left-sided-filling-pressures
#18
Yogesh N V Reddy, Abdallah El-Sabbagh, Rick A Nishimura
No abstract text is available yet for this article.
March 28, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29590304/long-term-thromboembolic-risk-in-patients-with-postoperative-atrial-fibrillation-after-coronary-artery-bypass-graft-surgery-and-patients-with-nonvalvular-atrial-fibrillation
#19
Jawad H Butt, Ying Xian, Eric D Peterson, Peter Skov Olsen, Rasmus Rørth, Anna Gundlund, Jonas B Olesen, Gunnar H Gislason, Christian Torp-Pedersen, Lars Køber, Emil L Fosbøl
Importance: New-onset postoperative atrial fibrillation (POAF) is a common complication of coronary artery bypass graft (CABG) surgery. However, the long-term risk of thromboembolism in patients who develop POAF after CABG surgery remains unknown. In addition, information on stroke prophylaxis in this setting is lacking. Objective: To examine stroke prophylaxis and the long-term risk of thromboembolism in patients with new-onset POAF after first-time isolated CABG surgery compared with patients with nonsurgical, nonvalvular atrial fibrillation (NVAF)...
March 28, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29590290/the-2017-aha-acc-performance-and-quality-measures-for-patients-with-acute-myocardial-infarction
#20
Hani Jneid, Biykem Bozkurt, Gregg C Fonarow
No abstract text is available yet for this article.
March 28, 2018: JAMA Cardiology
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