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JAMA Cardiology

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https://www.readbyqxmd.com/read/28329250/sudden-cardiac-arrest-risk-assessment-population-science-and-the-individual-risk-mandate
#1
Robert J Myerburg, Jeffrey J Goldberger
Importance: High-resolution stratification of risk of sudden cardiac arrest (SCA) in individual patients is a tool that is necessary for achieving effective and efficient application of data generated by population-based research. This concept is at the core of initiatives for merging cost effectiveness with maximized clinical efficiency and individual patient treatment. Observations: For this review, we analyzed data on sudden cardiac death and SCA available from population studies that included large longitudinal and cross-sectional databases, observational cohort studies, and randomized clinical trials...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28329205/regarding-twitter-as-a-potential-data-source-for-cardiovascular-disease-research
#2
R Jay Widmer, Suraj Kapa
No abstract text is available yet for this article.
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28329188/let-us-not-forget-the-long-term-safety-concerns-of-sacubitril-valsartan-reply
#3
Milton Packer
No abstract text is available yet for this article.
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28329180/let-us-not-forget-the-long-term-safety-concerns-of-sacubitril-valsartan
#4
Cian P McCarthy, John W McEvoy
No abstract text is available yet for this article.
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28329126/regarding-twitter-as-a-potential-data-source-for-cardiovascular-disease-research-reply
#5
Lauren Sinnenberg, David A Asch, Raina M Merchant
No abstract text is available yet for this article.
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28329057/coronary-artery-calcification-and-risk-of-cardiovascular-disease-and-death-among-patients-with-chronic-kidney-disease
#6
Jing Chen, Matthew J Budoff, Muredach P Reilly, Wei Yang, Sylvia E Rosas, Mahboob Rahman, Xiaoming Zhang, Jason A Roy, Eva Lustigova, Lisa Nessel, Virginia Ford, Dominic Raj, Anna C Porter, Elsayed Z Soliman, Jackson T Wright, Myles Wolf, Jiang He
Importance: Coronary artery calcification (CAC) is highly prevalent in dialysis-naive patients with chronic kidney disease (CKD). However, there are sparse data on the association of CAC with subsequent risk of cardiovascular disease and all-cause mortality in this population. Objective: To study the prospective association of CAC with risk of cardiovascular disease and all-cause mortality among dialysis-naive patients with CKD. Design, Setting, and Participants: The prospective Chronic Renal Insufficiency Cohort study recruited adults with an estimated glomerular filtration rate of 20 to 70 mL/min/1...
March 22, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28315622/subclinical-atherosclerosis-statin-eligibility-and-outcomes-in-african-american-individuals-the-jackson-heart-study
#7
Ravi V Shah, Aferdita Spahillari, Stanford Mwasongwe, J Jeffrey Carr, James G Terry, Robert J Mentz, Daniel Addison, Udo Hoffmann, Jared Reis, Jane E Freedman, Joao A C Lima, Adolfo Correa, Venkatesh L Murthy
Importance: Modern prevention guidelines substantially increase the number of individuals who are eligible for treatment with statins. Efforts to refine statin eligibility via coronary calcification have been studied in white populations but not, to our knowledge, in large African American populations. Objective: To compare the relative accuracy of US Preventive Services Task Force (USPSTF) and American College of Cardiology/American Heart Association (ACC/AHA) recommendations in identifying African American individuals with subclinical and clinical atherosclerotic cardiovascular disease (ASCVD)...
March 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28315573/mortality-length-of-stay-and-cost-implications-of-procedural-bleeding-after-percutaneous-interventions-using-large-bore-catheters
#8
Björn Redfors, Brendan M Watson, Thomas McAndrew, Emilie Palisaitis, Dominic P Francese, Mehdi Razavi, Jordan Safirstein, Roxana Mehran, Ajay J Kirtane, Philippe Généreux
Importance: Bleeding complications after percutaneous transcatheter interventions that used large-bore catheters are frequent and associated with high mortality and morbidity. Objective: To describe the incidence of bleeding complications among patients undergoing contemporary endovascular interventions involving large-bore catheters and its association with in-hospital mortality, length of stay, and health care cost. Design, Setting, and Participants: This retrospective cohort study analyzed all 17 672 patients from the Healthcare Cost and Utilization Project's National Inpatient Sample database who were recorded as having undergone a transcatheter aortic valve replacement (n = 3223), an endovascular aneurysm repair (n = 12 633), or a percutaneous left ventricular assist device implant (n = 1816) between January 1, 2012, and December 31, 2013...
March 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297015/mortality-following-cardiovascular-and-bleeding-events-occurring-beyond-1-year-after-coronary-stenting-a-secondary-analysis-of-the-dual-antiplatelet-therapy-dapt-study
#9
Eric A Secemsky, Robert W Yeh, Dean J Kereiakes, Donald E Cutlip, David J Cohen, P Gabriel Steg, Christopher P Cannon, Patricia K Apruzzese, Ralph B D'Agostino, Joseph M Massaro, Laura Mauri
Importance: Early cardiovascular and bleeding events after coronary stenting are associated with high risk of morbidity and mortality. Objective: To assess the prognosis of cardiovascular and bleeding events occurring beyond 1 year after coronary stenting. Design, Setting, and Participants: This secondary analysis is derived from data from the Dual Antiplatelet Therapy (DAPT) Study, a multicenter trial involving 220 US and international clinical sites from 11 countries...
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297007/cardiopulmonary-resuscitation-training-in-china-current-situation-and-future-development
#10
Feng Xu, Yun Zhang, Yuguo Chen
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297006/microangiopathy-arterial-stiffness-and-risk-stratification-in-patients-with-type-2-diabetes
#11
Alexios S Antonopoulos, Gerasimos Siasos, Dimitris Tousoulis
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297005/cardiac-arrest-in-any-location-the-need-for-fewer-bystanders-and-more-layperson-rescuers
#12
Clifton W Callaway
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297004/deciding-on-the-duration-of-dual-antiplatelet-therapy-when-the-choice-between-2-evils-is-still-evil
#13
Marco Valgimigli, Giuseppe Gargiulo
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297003/bystander-defibrillation-for-out-of-hospital-cardiac-arrest-in-public-vs-residential-locations
#14
Steen Møller Hansen, Carolina Malta Hansen, Fredrik Folke, Shahzleen Rajan, Kristian Kragholm, Linda Ejlskov, Gunnar Gislason, Lars Køber, Thomas A Gerds, Søren Hjortshøj, Freddy Lippert, Christian Torp-Pedersen, Mads Wissenberg
Importance: Bystander-delivered defibrillation (hereinafter referred to as bystander defibrillation) of patients with out-of-hospital cardiac arrests (OHCAs) remains limited despite the widespread dissemination of automated external defibrillators (AEDs). Objective: To examine calendar changes in bystander defibrillation and subsequent survival according to a public or a residential location of the cardiac arrest after nationwide initiatives in Denmark to facilitate bystander-mediated resuscitative efforts, including bystander defibrillation...
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28297000/thirty-two-year-old-woman-with-corrected-tetralogy-of-fallot
#15
D Brian Newman, William R Miranda, Heidi M Connolly
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28296997/jama-cardiology-inaugural-year-in-review
#16
Robert O Bonow
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28296995/microangiopathy-arterial-stiffness-and-risk-stratification-in-patients-with-type-2-diabetes-reply
#17
Benjamin M Scirica, Eugene Braunwald, Deepak L Bhatt
No abstract text is available yet for this article.
March 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28291870/long-term-low-density-lipoprotein-cholesterol-lowering-efficacy-persistence-and-safety-of-evolocumab-in-treatment-of-hypercholesterolemia-results-up-to-4-years-from-the-open-label-osler-1-extension-study
#18
Michael J Koren, Marc S Sabatine, Robert P Giugliano, Gisle Langslet, Stephen D Wiviott, Helina Kassahun, Andrea Ruzza, Yuhui Ma, Ransi Somaratne, Frederick J Raal
Importance: The Open-Label Study of Long-term Evaluation Against LDL-C (OSLER-1) evaluated the durability of long-term efficacy and safety during long-term therapy with evolocumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9). Objective: To determine whether LDL-C level reductions with evolocumab persist across different populations. Secondary objectives included assessment of adverse events, antidrug antibodies, and factors contributing to treatment discontinuation...
March 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28291866/long-term-safety-and-efficacy-of-achieving-very-low-levels-of-low-density-lipoprotein-cholesterol-a-prespecified-analysis-of-the-improve-it-trial
#19
Robert P Giugliano, Stephen D Wiviott, Michael A Blazing, Gaetano M De Ferrari, Jeong-Gun Park, Sabina A Murphy, Jennifer A White, Andrew M Tershakovec, Christopher P Cannon, Eugene Braunwald
Importance: In the Improved Reduction of Outcomes: Vytorin Efficacy International Trial, intensive low-density lipoprotein cholesterol (LDL-C)-reducing therapy with ezetimibe/simvastatin compared with simvastatin alone was associated with a significant reduction in cardiovascular events in 18 144 patients after acute coronary syndrome. The safety of very low LDL-C levels over the long-term is unknown. Objective: To assess the safety and clinical efficacy of achieving a very low (<30 mg/dL) level of LDL-C at 1 month using data from the Improved Reduction of Outcomes: Vytorin Efficacy International Trial...
March 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28291865/factors-affecting-the-cost-of-airplanes-and-use-of-proprotein-convertase-subtilisin-kexin-type-9-inhibitors
#20
Neil J Stone
No abstract text is available yet for this article.
March 14, 2017: JAMA Cardiology
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