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JAMA Cardiology

Aditya A Joshi, Joseph B Lerman, Amit K Dey, Aparna P Sajja, Agastya D Belur, Youssef A Elnabawi, Justin A Rodante, Tsion M Aberra, Jonathan Chung, Taufiq Salahuddin, Balaji Natarajan, Jenny Dave, Aditya Goyal, Jacob W Groenendyk, Joshua P Rivers, Yvonne Baumer, Heather L Teague, Martin P Playford, David A Bluemke, Mark A Ahlman, Marcus Y Chen, Joel M Gelfand, Nehal N Mehta
Importance: Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides a model to study the process of early atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify aortic VI, and coronary computed tomography angiography provides coronary artery disease (CAD) assessment through evaluation of total plaque burden (TB) and noncalcified coronary plaque burden (NCB), luminal stenosis, and high-risk plaques (HRP)...
September 12, 2018: JAMA Cardiology
Jagat Narula, Eloisa Arbustini
No abstract text is available yet for this article.
September 12, 2018: JAMA Cardiology
Mohammad Alkhalil, Colum Owens
No abstract text is available yet for this article.
September 12, 2018: JAMA Cardiology
Victoria M Stoll, Nigel E Drury, Sara Thorne, Tara Selman, Paul Clift, Hsu Chong, Peter J Thompson, R Katie Morris, Lucy E Hudsmith
Importance: A growing number of women are approaching childbearing age after arterial switch surgery for transposition of the great arteries. Prepregnancy counseling requires updated knowledge of the additional cardiovascular risks pregnancy poses for this cohort of women and the potential effect on their offspring; however, to our knowledge, this information is currently unknown. Objective: To determine the pregnancy outcomes of women with transposition of the great arteries after an arterial switch operation, as well as the outcomes of their offspring...
September 5, 2018: JAMA Cardiology
Lindsay R Pool, Hongyan Ning, John Wilkins, Donald M Lloyd-Jones, Norrina B Allen
Importance: Long-term cumulative systolic blood pressure (SBP) is significantly associated with increased rates of atherosclerotic cardiovascular disease (ASCVD) development independent of single SBP levels. However, published ASCVD risk prediction algorithms only include currently measured SBP. Objective: To determine whether including long-term (5- and 10-year) cumulative SBP in risk equations improves the predictive ability compared with single SBP measurements...
September 5, 2018: JAMA Cardiology
Haider J Warraich, Haolin Xu, Adam D DeVore, Roland Matsouaka, Paul A Heidenreich, Deepak L Bhatt, Adrian F Hernandez, Clyde W Yancy, Gregg C Fonarow, Larry A Allen
Importance: While 1 in 10 older patients hospitalized with heart failure (HF) die within 30 days, end-of-life care for this population is not well described. Objective: To assess rates of discharge to hospice, readmission after hospice, and survival in hospice in patients following hospital discharge. Design, Setting, and Participants: In this observational cohort analysis of patients in the multicenter American Heart Association Get With The Guidelines (GWTG)-HF registry linked to Medicare fee-for-service claims data, we analyzed patients 65 years and older discharged alive from the hospital between 2005 and 2014...
August 29, 2018: JAMA Cardiology
Kan Liu, Megha Dogra
No abstract text is available yet for this article.
August 29, 2018: JAMA Cardiology
Abdul Rahman A Abutaleb, Elizabeth M McNally, Sadiya S Khan, Allen S Anderson, James C Carr, Jane E Wilcox
Importance: Cardiac dysfunction is a leading cause of morbidity and mortality in Duchenne muscular dystrophy (DMD). This case highlights the importance of steroids in treating cardiac complications of DMD and the dangers of discontinuing or switching between steroid classes. Objective: To recognize the presentation of acute myocardial inflammation, or dystrophinitis, in DMD, which presents as myocarditis and to treat the myocardial inflammation and dilated cardiomyopathy associated with DMD through guideline-directed medical therapy, steroids, and serial surveillance for cardiac dysfunction...
August 29, 2018: JAMA Cardiology
Shunichi Nakagawa, A Reshad Garan
No abstract text is available yet for this article.
August 29, 2018: JAMA Cardiology
Sanjiv J Shah, Ted Feldman, Mark J Ricciardi, Rami Kahwash, Scott Lilly, Sheldon Litwin, Chris D Nielsen, Pim van der Harst, Elke Hoendermis, Martin Penicka, Jozef Bartunek, Peter S Fail, David M Kaye, Anthony Walton, Mark C Petrie, Niki Walker, Anupam Basuray, Steven Yakubov, Scott L Hummel, Stanley Chetcuti, Rhondalyn Forde-McLean, Howard C Herrmann, Daniel Burkhoff, Joseph M Massaro, John G F Cleland, Laura Mauri
Importance: In patients with heart failure (HF) and left ventricular ejection fraction (LVEF) equal to or greater than 40%, a transcatheter interatrial shunt device (IASD; Corvia Medical) reduces exercise pulmonary capillary wedge pressure (PCWP) and is safe compared with sham control treatment at 1 month of follow-up. The longer-term safety and patency of the IASD has not yet been demonstrated in the setting of a randomized clinical trial (RCT). Objective: To evaluate the 1-year safety and clinical outcomes of the IASD compared with a sham control treatment...
August 27, 2018: JAMA Cardiology
Ayman Samman Tahhan, Muthiah Vaduganathan, Stephen J Greene, Gregg C Fonarow, Mona Fiuzat, Mariell Jessup, JoAnn Lindenfeld, Christopher M O'Connor, Javed Butler
Importance: Despite the importance of age, sex, and race/ethnicity representativeness in clinical trials, limited data exist regarding the enrollment trends of these groups in contemporary heart failure (HF) trials. Objective: To characterize the representation of older patients, women, and racial and ethnic minorities in HF trials. Evidence Review: We performed a systematic search of HF trials enrolling more than 400 participants published between January 2001 and December 2016 using PubMed/Medline and ClinicalTrials...
August 22, 2018: JAMA Cardiology
Peder Langeland Myhre, Muthiah Vaduganathan, Brian L Claggett, Inder S Anand, Nancy K Sweitzer, James C Fang, Eileen O'Meara, Sanjiv J Shah, Akshay S Desai, Eldrin F Lewis, Jean Rouleau, Bertram Pitt, Marc A Pfeffer, Scott D Solomon
Importance: Contemporary clinical trials of heart failure with preserved ejection fraction (HFpEF) apply natriuretic peptide (NP) thresholds to identify patients who are more likely to have the disease of interest and to enrich the baseline risk of the enrolled cohort. Objective: To determine whether age, race/ethnicity, obesity, renal function, and atrial fibrillation (AF) affect the levels of NPs in HFpEF and whether the prognostic significance of NPs varies in these clinically important subgroups...
August 22, 2018: JAMA Cardiology
Valerie D Myers, Glenn S Gerhard, Dennis M McNamara, Dhanendra Tomar, Muniswamy Madesh, Scott Kaniper, Frederick V Ramsey, Susan G Fisher, Roxann G Ingersoll, Laura Kasch-Semenza, JuFang Wang, Karen Hanley-Yanez, Bonnie Lemster, Jessica A Schwisow, Amrut V Ambardekar, Seta H Degann, Michael R Bristow, Richard Sheppard, Jeffrey D Alexis, Douglas G Tilley, Christopher D Kontos, Joseph M McClung, Anne L Taylor, Clyde W Yancy, Kamel Khalili, Jonathan G Seidman, Christine E Seidman, Charles F McTiernan, Joseph Y Cheung, Arthur M Feldman
Importance: The prevalence of nonischemic dilated cardiomyopathy (DCM) is greater in individuals of African ancestry than in individuals of European ancestry. However, little is known about whether the difference in prevalence or outcomes is associated with functional genetic variants. Objective: We hypothesized that Bcl2-associated anthanogene 3 (BAG3) genetic variants were associated with outcomes in individuals of African ancestry with DCM. Design: This multicohort study of the BAG3 genotype in patients of African ancestry with dilated cardiomyopathy uses DNA obtained from African American individuals enrolled in 3 clinical studies: the Genetic Risk Assessment of African Americans With Heart Failure (GRAHF) study; the Intervention in Myocarditis and Acute Cardiomyopathy Trial-2 (IMAC-2) study; and the Genetic Risk Assessment of Cardiac Events (GRACE) study...
August 22, 2018: JAMA Cardiology
Samantha Barratt Ross, Christopher Semsarian
No abstract text is available yet for this article.
August 15, 2018: JAMA Cardiology
Karima Addetia, Roberto M Lang
No abstract text is available yet for this article.
August 15, 2018: JAMA Cardiology
E Mara Vollema, Tadafumi Sugimoto, Mylène Shen, Lionel Tastet, Arnold C T Ng, Rachid Abou, Nina Ajmone Marsan, Bart Mertens, Raluca Dulgheru, Patrizio Lancellotti, Marie-Annick Clavel, Philippe Pibarot, Philippe Genereux, Martin B Leon, Victoria Delgado, Jeroen J Bax
Importance: The optimal timing to operate in patients with asymptomatic severe aortic stenosis (AS) remains controversial. Left ventricular global longitudinal strain (LV GLS) may help to identify patients who might benefit from undergoing earlier aortic valve replacement. Objective: To investigate the prevalence of impaired LV GLS, the natural course of LV GLS, and its prognostic implications in patients with asymptomatic severe AS with preserved left ventricular ejection fraction (LVEF)...
August 15, 2018: JAMA Cardiology
James D Thomas
No abstract text is available yet for this article.
August 15, 2018: JAMA Cardiology
Kotaro Nochioka, Gabriela Querejeta Roca, Brian Claggett, Tor Biering-Sørensen, Kunihiro Matsushita, Chung-Lieh Hung, Scott D Solomon, Dalane Kitzman, Amil M Shah
Importance: Limited data exist on the prevalence and prognostic importance of right ventricular (RV) dysfunction for heart failure (HF) in the general population. Objective: To assess the prevalence of RV dysfunction and its association with HF and mortality in a community-based elderly cohort. Design, Setting, and Participants: Cross-sectional and time-to-event analysis of participants in the Atherosclerosis Risks in the Community (ARIC), a multicenter, population-based cohort study at the fifth study visit from 2011 to 2013, with a median follow-up of 4...
August 15, 2018: JAMA Cardiology
(no author information available yet)
No abstract text is available yet for this article.
August 8, 2018: JAMA Cardiology
Tianxi Cai, Yichi Zhang, Yuk-Lam Ho, Nicholas Link, Jiehuan Sun, Jie Huang, Tianrun A Cai, Scott Damrauer, Yuri Ahuja, Jacqueline Honerlaw, Jie Huang, Lauren Costa, Petra Schubert, Chuan Hong, David Gagnon, Yan V Sun, J Michael Gaziano, Peter Wilson, Kelly Cho, Philip Tsao, Christopher J O'Donnell, Katherine P Liao
Importance: Electronic health record (EHR) biobanks containing clinical and genomic data on large numbers of individuals have great potential to inform drug discovery. Individuals with interleukin 6 receptor (IL6R) single-nucleotide polymorphisms (SNPs) who are not receiving IL6R blocking therapy have biomarker profiles similar to those treated with IL6R blockers. This gene-drug pair provides an example to test whether associations of IL6R SNPs with a broad range of phenotypes can inform which diseases may benefit from treatment with IL6R blockade...
August 8, 2018: JAMA Cardiology
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