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European Heart Journal. Cardiovascular Pharmacotherapy

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https://www.readbyqxmd.com/read/29726985/expert-consensus-document-on-the-management-of-hyperkalaemia-in-patients-with-cardiovascular-disease-treated-with-raas-inhibitors-coordinated-by-the-working-group-on-cardiovascular-pharmacotherapy-of-the-european-society-of-cardiology
#1
Giuseppe M C Rosano, Juan Tamargo, Keld P Kjeldsen, Mitja Lainscak, Stefan Agewall, Stefan D Anker, Claudio Ceconi, Andrew J S Coats, Heinz Drexel, Gerasimos Filippatos, Juan Carlos Kaski, Lars Lund, Alexander Niessner, Gianluigi Savarese, Thomas A Schmidt, Petar Seferovic, Sven Wassmann, Thomas Walther, Basil S Lewis
Renin angiotensin aldosterone system inhibitors/antagonists/blockers (RAASi) are a cornerstone in treatment of patients with cardiovascular diseases especially in those with heart failure (HF) due to their proven effect on surrogate and hard end-points. RAASi are also the basis in treatment of arterial hypertension and they are furthermore indicated to reduce events and target organ damage in patients with diabetes and chronic kidney disease, where they have specific indication because of the evidence of benefit...
May 3, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29562254/corrigendum
#2
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29528386/preadmission-use-of-platelet-inhibitors-and-short-term-stroke-mortality-a-population-based-cohort-study
#3
Morten Würtz, Morten Schmidt, Erik Lerkevang Grove, Erzsébet Horváth-Puhó, Victor W Henderson, Christian Fynbo Christiansen, Henrik Toft Sørensen
Aims: The impact of preadmission antiplatelet treatment on prognosis after stroke is poorly understood. We therefore investigated whether preadmission use of aspirin and clopidogrel was associated with mortality in patients hospitalized with ischemic stroke, intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH). Methods and Results: We used nationwide population-based registries to identify all first-time hospitalizations for stroke and subsequent mortality in patients treated with aspirin and clopidogrel in Denmark during 2004-2012...
March 8, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29514184/the-quality-of-warfarin-therapy-and-cha2ds2-vasc-score-associate-with-the-incidence-of-myocardial-infarction-and-cardiovascular-outcome-in-patients-with-atrial-fibrillation-data-from-the-nationwide-finwaf-registry
#4
M J Pekka Raatikainen, Tero Penttilä, Pasi Korhonen, Juha Mehtälä, Riitta Lassila, Mika Lehto
Aims: The impact of the quality of warfarin therapy on cardiovascular outcomes excluding stroke is largely unknown. The aims of this study were to evaluate the association between the warfarin control and the incidence and outcome of myocardial infarction (MI), and to validate the predictive value of the CHA2DS2-VASc score for MI in AF patients taking warfarin. Methods and Results: The nationwide FinWAF registry consists of 54568 AF patients (mean age 73.1±10...
March 5, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29490032/heart-rate-beta-blocker-use-and-outcomes-of-heart-failure-with-reduced-ejection-fraction
#5
Nasrien Ibrahim, Hanna K Gaggin, Alexander Turchin, Harshali K Patel, Yang Song, April Trebnick, Gheorghe Doros, Juan F Maya, Christopher P Cannon, James L Januzzi
Background: High resting heart rate (HR; ≥70 beats/minute) is associated with worse clinical outcomes in heart failure with reduced ejection fraction (HFrEF). Aims: HR, guideline-directed medical therapy (GDMT) with BB, and cardiovascular (CV) outcomes were evaluated in a large integrated health network. Methods: Using electronic health records we examined patients with chronic HFrEF (EF ≤ 35%) in sinus rhythm with at least 1 year of follow-up and available serial HR and medication data between January 1, 2000 and December 31, 2014...
February 27, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29554294/cardiovascular-pharmacotherapy-and-real-world-data
#6
Stefan Agewall
No abstract text is available yet for this article.
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29554293/how-does-the-trs-2%C3%A2-p-score-relate-to-real-world-patients
#7
Marc P Bonaca, Gaetano M De Ferrari, Dan Atar, Lori D Bash, Dominik Lautsch, Erin A Bohula, Martin Horack, Philippe Brudi, Jean Ferrieres, Anselm K Gitt
No abstract text is available yet for this article.
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29554292/trimetazidine-is-there-a-role-beyond-angina
#8
Jason M Tarkin, Juan Carlos Kaski
No abstract text is available yet for this article.
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29394340/trends-in-optimal-medical-therapy-prescription-and-mortality-after-admission-for-acute-coronary-syndrome-a-9-year-experience-in-a-real-world-setting
#9
Niels P G Hoedemaker, Peter Damman, Jan Paul Ottervanger, Jan Henk E Dambrink, A T Marcel Gosselink, Elvin Kedhi, Evelien Kolkman, Robbert J de Winter, Arnoud W J van 't Hof
Aims: Optimal medical therapy (OMT) is recommended in acute coronary syndrome (ACS) patients. Few studies present temporal trends of OMT prescription and its impact on outcomes in a real-world setting. We aimed to evaluate OMT prescription in a real-world ACS population and its relation to mortality during almost a decade. Methods and results: Consecutive ST-elevation myocardial infarction and non-ST-elevation myocardial infarction (NSTEMI) patients (n = 9202) admitted to a single Dutch tertiary hospital between 2006 and 2014 were included and followed for drug prescription and mortality up to 1 year...
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29385429/antithrombotic-therapy-use-and-clinical-outcomes-following-thrombo-embolic-events-in-patients-with-atrial-fibrillation-insights-from-aristotle
#10
Shinya Goto, Peter Merrill, Lars Wallentin, Daniel M Wojdyla, Michael Hanna, Alvaro Avezum, J Donald Easton, Veli-Pekka Harjola, Kurt Huber, Basil S Lewis, Alexander Parkhomenko, Jun Zhu, Christopher B Granger, Renato D Lopes, John H Alexander
Aims: We investigated baseline characteristics, antithrombotic use, and clinical outcomes of patients with atrial fibrillation (AF) and a thrombo-embolic event in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) study to better inform the care of these high-risk patients. Method and results: Thrombo-embolic events were defined as stroke (ischaemic or unknown cause) or systemic embolism (SE). Clinical outcomes were estimated using the Kaplan-Meier method...
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29272379/annual-adverse-event-profiles-after-clopidogrel-prasugrel-and-ticagrelor-in-the-food-and-drug-administration-adverse-event-reporting-system
#11
Vasily Cherepanov, Seth D Fortmann, Moo Hyun Kim, Thomas A Marciniak, Oleg Litvinov, Kyryl Mihalev, Victor L Serebruany
No abstract text is available yet for this article.
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28950374/non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation-and-valvular-heart-disease-systematic-review-and-meta-analysis
#12
Daniel Caldeira, Cláudio David, João Costa, Joaquim J Ferreira, Fausto J Pinto
The non-vitamin K antagonist oral anticoagulants (NOACs) were approved for non-valvular atrial fibrillation (AF) but this term may be misnomer. Thus, the term non-mechanical and rheumatic mitral valvular (non-MARM) AF was proposed to exclude patients with valvular heart disease (VHD) without contraindications for NOACs. We aimed to review the efficacy and safety of NOACs in patients with AF and VHD compared to Vitamin K Antagonists (VKA). We performed a systematic review with meta-analysis (PROSPERO CRD42015024837) including data from randomized controlled trials (RCTs) retrieved in November 2016...
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28475676/comparative-effectiveness-of-enalapril-lisinopril-and-ramipril-in-the-treatment-of-patients-with-chronic-heart-failure-a-propensity-score-matched-cohort-study
#13
Hanna Fröhlich, Felix Henning, Tobias Täger, Dieter Schellberg, Morten Grundtvig, Kevin Goode, Anna Corletto, Syed Kazmi, Torstein Hole, Hugo A Katus, Dan Atar, John G F Cleland, Stefan Agewall, Lutz Frankenstein, Andrew L Clark
Aims: Angiotensin-converting enzyme inhibitors (ACEIs) are recommended as first-line therapy in patients with heart failure with reduced ejection fraction (HFrEF). The comparative effectiveness of different ACEIs is not known. Methods and results: A total of 4723 outpatients with stable HFrEF prescribed enalapril, lisinopril, or ramipril were identified from three registries in Norway, England, and Germany. In three separate matching procedures, patients were individually matched with respect to both dose equivalents and their respective propensity scores for ACEI treatment...
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/27773877/erratum-to-sglt1-does-compensate-for-sglt2-inhibition
#14
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29452338/potential-benefits-of-prasugrel-and-ticagrelor-is-diabetics-are-not-substantiated-by-the-food-and-drug-administration-adverse-event-repository
#15
Victor L Serebruany, Moo Hyun Kim, Nikita Lomakin
No abstract text is available yet for this article.
February 14, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29370383/circadian-variation-of-ticagrelor-induced-platelet-inhibition-in-healthy-adulty
#16
Stephane Fournier, Florine Guenat, Anne Fournier, Lorenzo Alberio, Olivier Bonny, Debora Bertaggia Calderara, Daniel Bardy, Nathalie Lauriers, Brahim Harbaoui, Pierre Monney, Patrizio Pascale, Eric Eeckhout, Olivier Muller
Aims: The circadian variation of platelet aggregation is well demonstrated. However, whether this has an impact on antiplatelet inhibition therapy is poorly documented. We aimed to observe whether ticagrelor-induced platelet inhibition follows a circadian rhythm. Methods and Results: The study included 25 healthy volunteers (11 female;14 male). Blood samples were collected every 4 hours. Ticagrelor was added in vitro at a concentration that provided 50% inhibition of the maximum response using the VerifyNow System Platelet Reactivity Test® thus avoiding any bias induced by circadian gastro-intestinal absorption...
January 23, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29319788/relationship-of-loop-diuretic-use-with-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction
#17
David Montero, Thomas Haider
No abstract text is available yet for this article.
January 8, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29315398/cardiovascular-pharmacotherapy
#18
Stefan Agewall
No abstract text is available yet for this article.
January 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29315397/cost-effectiveness-with-pcsk9-inhibitors-a-matter-of-costs
#19
Heinz Drexel
No abstract text is available yet for this article.
January 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/29315396/market-licensing-of-type-2-diabetes-medicinal-products-based-on-patient-relevant-hard-outcomes-is-there-hope
#20
Thomas A Schmidt
No abstract text is available yet for this article.
January 1, 2018: European Heart Journal. Cardiovascular Pharmacotherapy
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