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Journal of Global Oncology

Anne-Marie Barron, Jenna Moran, Shabnam Sultana Nina, Jason Harlow, Meena Gyawali, Farhad Hossain, Mark Brezina, Caroline Callahan, Judy Curran, Colleen Danielson, Ellen Fitzgerald, Judy Foster, Emily Erhardt, Christine Shaughnessy, Albert C Yeh, Bimalangshu R Dey
In 2012, the Minister of Health and other leaders in the Bangladesh government approached Massachusetts General Hospital to establish the country's first bone marrow transplant program at Dhaka Medical College Hospital to serve the needs of the people of Bangladesh. Stated goals of this collaboration included a broad focus on the care of oncology patients with a specific emphasis on care of patients with hematologic malignancies and of women with gynecologic cancers. The purpose of this article is to describe the international nursing collaboration between Massachusetts General Hospital, Simmons College, the AK Khan Healthcare Trust in Dhaka, and Dhaka Medical College Hospital that was established to share nursing knowledge and to build specialized professional nursing capacities to deliver high-quality cancer care in the public sector...
September 2018: Journal of Global Oncology
Punit Jain, Anu Korula, Prashant Deshpande, Nisham Pn, Ansu Abu Alex, Aby Abraham, Alok Srivastava, Nancy Beryl Janet, Kavitha M Lakshmi, Poonkuzhali Balasubramanian, Biju George, Vikram Mathews
Purpose Limited data exist on intensifying chemotherapy regimens in the treatment of adult acute lymphoblastic leukemia (ALL) outside the setting of a clinical trial. Materials and Methods Retrospectively, data from 507 consecutive adults (age ≥ 15 years) with a diagnosis of ALL treated at our center were analyzed. Standard-risk (SR) patients were offered treatment with a modified German Multicenter ALL (GMALL) regimen, whereas high-risk (HR) patients were offered intensification of therapy with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HCVAD)...
September 2018: Journal of Global Oncology
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Journal of Global Oncology
Omalkhair Abulkhair, Mohammed Al Balwi, Ola Makram, Lamia Alsubaie, Medhat Faris, Hussam Shehata, Ahmed Hashim, Banu Arun, Ahmed Saadeddin, Ezzeldin Ibrahim
Purpose Over the past three decades, the incidence rate of breast cancer (BC) among Arab women has continually increased. However, data on the prevalence of BRCA1/2 mutations are scarce. Although the population in Saudi Arabia is at large homogeneous and consanguinity is common, especially in the central, eastern, and southern regions of the country, the prevalence of BRCA1 and BRCA2 mutations and the characteristics of BC are not well studied in the country. Methods This prospective observational study intended to determine the prevalence of BRCA1 and BRCA2 mutations and sought to examine the clinicopathologic features of BC associated with these mutations...
August 2018: Journal of Global Oncology
Rohini K Bhatia, Sarah Rayne, William Rate, Lame Bakwenabatsile, Barati Monare, Chidinma Anakwenze, Preet Dhillon, Mohan Narasimhamurthy, Scott Dryden-Peterson, Surbhi Grover
Purpose Delays in diagnosis and treatment of cancers can lead to poor survival. These delays represent a multifaceted problem attributable to patient, provider, and systemic factors. We aim to quantify intervals from symptom onset to treatment start among patients with cancer in Botswana and to understand potential risk factors for delay. Patients and Methods From December 2015 to January 2017, we surveyed patients seen in an oncology clinic in Botswana. We calculated proportions of patients who experienced delays in appraisal (between detecting symptoms and perceiving a reason to discuss them with provider, defined as > 1 month), help seeking (between discussing symptoms and first consultation with provider, defined as > 1 month), diagnosis (between first consultation and receiving a diagnosis, defined as > 3 months), and treatment (between diagnosis and starting treatment, defined as > 3 months)...
August 2018: Journal of Global Oncology
Pedro Isaacsson Velho, Mirella Nardo, Manoel Carlos Leonardi de Azevedo Souza, Renata R C Colombo Bonadio, Guilherme Nader Marta, David Q B Muniz, Diogo Assed Bastos, Carlos Dzik
Purpose Sunitinib and pazopanib are multitargeted tyrosine kinase inhibitors (TKIs) that act against vascular endothelial growth factor receptors and are standard first-line treatment options for metastatic clear cell renal cell carcinoma (ccRCC). The Brazilian public health system diverges from the randomized clinical trials in the availability of first and subsequent lines of treatment and in clinical and demographic characteristics of patients. Therefore, it is essential to describe the history of advanced ccRCC during and after TKI treatment in this population...
August 2018: Journal of Global Oncology
Joanne T Chang, Jihyoun Jeon, Hutcha Sriplung, Seesai Yeesoonsang, Surichai Bilheem, Laura Rozek, Imjai Chitapanarux, Donsuk Pongnikorn, Karnchana Daoprasert, Patravoot Vatanasapt, Krittika Suwanrungruang, Rafael Meza
Purpose Lung cancer is one of the most common cancers worldwide and in Thailand. We characterize and forecast region-specific patterns of lung cancer incidence by histology and sex. Methods We analyzed lung cancer incidence trends in Thailand by histology (adenocarcinoma [AdC]; squamous cell carcinoma [SCC]; and large-cell, small-cell, and other carcinomas) from 1990 to 2014 in four cancer registries in three regions (north, Chiang Mai Province and Lampang Province; northeast: Khon Kaen Province; south: Songkhla Province)...
August 2018: Journal of Global Oncology
Aubrey L Doede, Emma M Mitchell, Dan Wilson, Reanna Panagides, Mônica Oliveira Batista Oriá
Purpose Breast cancer (BCA) is the most common cancer and leading cause of cancer mortality among women in Latin America and the Caribbean (LAC), and the number of deaths from BCA is expected to continue to increase. Although barriers to care include the physical accessibility of screening resources, personal and cultural barriers must be explored to understand necessary next steps to increase access to preventive care. The purpose of this in-depth narrative literature review was to explore empiric literature that surrounds the knowledge, attitudes, and beliefs toward BCA screening practices among women in LAC...
August 2018: Journal of Global Oncology
Susan M Love, Wendie A Berg, Christine Podilchuk, Ana Lilia López Aldrete, Aarón Patricio Gaxiola Mascareño, Krishnamohan Pathicherikollamparambil, Ananth Sankarasubramanian, Leah Eshraghi, Richard Mammone
Purpose In low- to middle-income countries (LMICs), most breast cancers present as palpable lumps; however, most palpable lumps are benign. We have developed artificial intelligence-based computer-assisted diagnosis (CADx) for an existing low-cost portable ultrasound system to triage which lumps need further evaluation and which are clearly benign. This pilot study was conducted to demonstrate that this approach can be successfully used by minimally trained health care workers in an LMIC country. Patients and Methods We recruited and trained three nonradiologist health care workers to participate in an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant pilot study in Jalisco, Mexico, to determine whether they could use portable ultrasound (GE Vscan Dual Probe) to acquire images of palpable breast lumps of adequate quality for accurate computer analysis...
August 2018: Journal of Global Oncology
Catherine Duggan, Tauane A Cruz, Maisa R T Porto, Cristiani L M S Borges, Allison Dvaladze, Benjamin O Anderson, Anna Cabanes
No abstract text is available yet for this article.
August 2018: Journal of Global Oncology
Sally N Adebamowo, Ayotunde Famooto, Eileen O Dareng, Oluwatoyosi Olawande, Olayinka Olaniyan, Richard Offiong, Clement A Adebamowo
Purpose There is a dearth of data on clearance of cervical human papillomavirus (HPV) infection among women in West Africa. We examined the clearance of low-risk (lr) and high-risk (hr) cervical HPV infections, and the factors associated with these measures in HIV-negative and HIV-positive women. Methods We studied 630 Nigerian women involved in a study of HPV infection using short polymerase chain reaction fragment-10 assay and line probe assay-25. Research nurses used a cervical brush to collect samples of exfoliated cervical cells from all the study participants...
July 2018: Journal of Global Oncology
Sana Al-Sukhun, Sarah Temin, Mariana Chavez-MacGregor, Neelima Denduluri, Thomas K Oliver, Doug Pyle, Manish A Shah, Julie Gralow
The objectives of this article are to describe the ASCO Resource-Stratified Guidelines and to provide background within the context of ASCO Guidelines and efforts to address the global cancer burden.
July 2018: Journal of Global Oncology
Jacqueline Alcalde-Castro, Thierry Hernández-Gilsoul, Ismael Domínguez-Rosado, Yanin Chavarri-Guerra, Enrique Soto Perez-de-Celis
No abstract text is available yet for this article.
July 2018: Journal of Global Oncology
Rachel E McCarroll, Beth M Beadle, Peter A Balter, Hester Burger, Carlos E Cardenas, Sameera Dalvie, David S Followill, Kelly D Kisling, Michael Mejia, Komeela Naidoo, Chris L Nelson, Christine B Peterson, Karin Vorster, Julie Wetter, Lifei Zhang, Laurence E Court, Jinzhong Yang
Purpose We assessed automated contouring of normal structures for patients with head-and-neck cancer (HNC) using a multiatlas deformable-image-registration algorithm to better provide a fully automated radiation treatment planning solution for low- and middle-income countries, provide quantitative analysis, and determine acceptability worldwide. Methods Autocontours of eight normal structures (brain, brainstem, cochleae, eyes, lungs, mandible, parotid glands, and spinal cord) from 128 patients with HNC were retrospectively scored by a dedicated HNC radiation oncologist...
July 2018: Journal of Global Oncology
Felicia Marie Knaul, Hector Arreola-Ornelas, Natalia M Rodriguez, Oscar Méndez-Carniado, Xiaoxiao Jiang Kwete, Esteban Puentes-Rosas, Afsan Bhadelia
Purpose The incidence of infection-associated cancers and lethality of cancers amenable to treatment are closely correlated with the income of countries. We analyzed a core part of this global cancer divide-the distribution of premature mortality across country income groups and cancers-applying novel approaches to measure avoidable mortality and identify priorities for public policy. Methods We analyzed avoidable cancer mortality using set lower- and upper-bound age limits of 65 and 75 years (empirical approach), applying cancer-specific and country income group-specific ages of death (feasibility approach), and applying cancer-specific ages of death of high-income countries to all low- and middle-income countries (LMICs; social justice approach)...
July 2018: Journal of Global Oncology
Claire M Wagner, Federico Antillón, François Uwinkindi, Tran Van Thuan, Sandra Luna-Fineman, Pham Tuan Anh, Tran Thanh Huong, Patricia Valverde, Arielle Eagan, Pham Van Binh, Tien Nguyen Quang, Sonali Johnson, Agnes Binagwaho, Julie Torode
Purpose The global burden of cancer is slated to reach 21.4 million new cases in 2030 alone, and the majority of those cases occur in under-resourced settings. Formidable changes to health care delivery systems must occur to meet this demand. Although significant policy advances have been made and documented at the international level, less is known about the efforts to create national systems to combat cancer in such settings. Methods With case reports and data from authors who are clinicians and policymakers in three financially constrained countries in different regions of the world-Guatemala, Rwanda, and Vietnam, we examined cancer care programs to identify principles that lead to robust care delivery platforms as well as challenges faced in each setting...
July 2018: Journal of Global Oncology
Eriko Shiraishi, Kouhei Sugimoto, Jason Solomon Shapiro, Yuki Ito, Keiko Kamoshita, Atsuko Kusuhara, Takayuki Haino, Tomoe Koizumi, Aikou Okamoto, Nao Suzuki
Purpose The oncofertility decision tree was developed by the oncofertility consortium as a tool to support healthcare professionals and patients through the complicated process of deciding the most appropriate fertility preservation strategy for patients with cancer. Various strategies include oocyte retrieval, oocyte donation, use of a gestational carrier and adoption. However, differences in the cultural and legal landscape present serious barriers to utilizing some of these strategies in Japan. Patients and Methods We surveyed Japanese oncofertility stakeholders including 60 cancer survivors, 27 oncology facilities, 78 reproductive medicine facilities and 15 adoption agencies by a questionnaire to characterize awareness among oncofertility stakeholders in Japan about parenting options including adoption to inform work to establish guidelines for decision-making by cancer survivors in an oncofertility...
July 2018: Journal of Global Oncology
Linus Chuang
No abstract text is available yet for this article.
July 2018: Journal of Global Oncology
Prachi Mittal, Supriya Chopra, Sidharth Pant, Umesh Mahantshetty, Reena Engineer, Jaya Ghosh, Sudeep Gupta, Yogesh Ghadi, Siji Menachery, Jamema Swamidas, Lavanya Gurram, Shyam Kishore Shrivastava
Purpose Recent guidelines recommend magnetic resonance imaging-based brachytherapy (MRBT) for locally advanced cervical cancer. However, its implementation is challenging within the developing world. This article reports the outcomes of patients with locally advanced cervical cancer treated with chemoradiation and point A-based brachytherapy (BT) using x-ray- or computed tomography-based planning. Methods Patients treated between January 2014 and December 2015 were included. Patients underwent x-ray- or computed tomography-based BT planning with an aim to deliver equivalent doses in 2 Gy (EQD2) > 84 Gy10 to point A while minimizing maximum dose received by rectum or bladder to a point or 2 cc volume to < 75 Gy EQD2 and < 90 Gy EQD2, respectively...
July 2018: Journal of Global Oncology
Supriya J Chopra, Ashwathy Mathew, Amita Maheshwari, Neerja Bhatla, Shalini Singh, Bhawana Rai, Shylasree T Surappa, Jaya Ghosh, Dayanand Sharma, Jaydip Bhaumik, Manash Biswas, Kedar Deodhar, Palak Popat, Sushil Giri, Umesh Mahantshetty, Hemant Tongaonkar, Ramesh Billimaga, Reena Engineer, Surbhi Grover, Abraham Pedicayil, Jyoti Bajpai, Bharat Rekhi, Aruna Alihari, Govind Babu, Rajkumar Thangrajan, Santosh Menon, Sneha Shah, Sidhanna Palled, Yogesh Kulkarni, Seema Gulia, Lavanya Naidu, Meenakshi Thakur, Venkatesh Rangrajan, Rajendra Kerkar, Sudeep Gupta, Shyam K Shrivastava
Standard guidelines for the management of early and locally advanced cervical cancer are available from various academic consortiums nationally and internationally. However, implementing standard-of-care treatment poses unique challenges within low- and middle-income countries, such as India, where diverse clinical care practices may exist. The National Cancer Grid, a consortium of 108 institutions in India, aims to homogenize care for patients with cervical cancer by achieving consensus on not only imaging and management, but also in addressing potential solutions to prevalent challenges that affect the homogenous implementation of standard-of-care treatment...
July 2018: Journal of Global Oncology
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