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Journal of Global Oncology

Kim-Son H Nguyen, Henning Stehr, Li Zhou, Anh-Hoa Nguyen, Pham Nhu Hiep, Nguyen Van Cau, Phan Canh Duy, Richard Thorp, Heather A Wakelee, Maximilian Diehn, Joel W Neal
PURPOSE: Discoveries of oncogenic driver alterations in non-small-cell lung cancer (NSCLC) have been accompanied by the development of effective targeted therapies. The frequencies of these mutations vary between populations but are less well characterized in the Vietnamese population. In this study, we analyzed the frequencies of lung cancer driver oncogenic alterations in Vietnamese patients compared with Vietnamese patients treated in the United States. METHODS: We collected data on tumor and disease characteristics of Vietnamese patients with NSCLC treated at Stanford...
November 2018: Journal of Global Oncology
Zi-Yi Yeoh, Maheswari Jaganathan, Nadia Rajaram, Sudha Rawat, Nurul Ain Tajudeen, Norlia Rahim, Nur Hidayati Zainal, Sakthi Maniam, Ushananthiny Suvelayutnan, Rahani Yaacob, Vijayalakshmi Krishnapillai, Meor Zamari Meor Kamal, Soo-Hwang Teo, Mohamed Yusof Abdul Wahab
PURPOSE: Late stage at presentation and poor adherence to treatment remain major contributors to poor survival in low- and middle-income countries (LMICs). Patient navigation (PN) programs in the United States have led to improvement in diagnostic or treatment timeliness, particularly for women in lower socioeconomic classes or minority groups. To date, studies of PN in Asia have been limited. We aimed to assess the feasibility of PN in a state-run hospital in an LMIC and to report the impact on diagnostic and treatment timeliness for patients in its first year of implementation...
November 2018: Journal of Global Oncology
Vinayak Palve, Jamir Bagwan, Neeraja M Krishnan, Manisha Pareek, Udita Chandola, Amritha Suresh, Gangotri Siddappa, Bonney L James, Vikram Kekatpure, Moni Abraham Kuriakose, Binay Panda
PURPOSE: Accurate detection of human papillomavirus (HPV) in oral cavity squamous cell carcinoma (OSCC) is essential to understanding the role of HPV in disease prognosis and management of patients. We used different analytes and methods to understand the true prevalence of HPV in a cohort of patients with OSCC with different molecular backgrounds, and we correlated HPV data with patient survival. METHODS: We integrated data from multiple analytes (HPV DNA, HPV RNA, and p16), assays (immunohistochemistry, polymerase chain reaction [PCR], quantitative PCR [qPCR], and digital PCR), and molecular changes (somatic mutations and DNA methylation) from 153 patients with OSCC to correlate p16 expression, HPV DNA, and HPV RNA with HPV incidence and patient survival...
November 2018: Journal of Global Oncology
Shahin Sayed, Andrew Field, Jamilla Rajab, Anderson Mutuiri, Jessie Githanga, Mary Mungania, Nancy Okinda, Zahir Moloo, Abubakar Abdillah, Brian Ayara, Erick Chesori, Julia Muthua, Leah Obosy, Thaddeus Massawa, Okoth Obiero, Elizabeth Kagotho, Peter K Shikuku, Andrew K Gachii, Eunida Migide, Donstefano Muninzwa, Sanford M Dawsey, Lucy Muchiri
PURPOSE: Fine-needle aspiration biopsy (FNAB) cytology is a simple, inexpensive, and accurate diagnostic test for benign, infectious, and malignant lesions of the breast, thyroid, lymph nodes, and other organs. Similarly, bone marrow aspiration and trephine (BMAT) biopsy procedures are relatively simple and inexpensive techniques that are important for diagnosing and monitoring many hematologic diseases including leukemias and lymphomas. However, the scarcity of pathologists in Kenya limits patient access to these simple diagnostic tests...
November 2018: Journal of Global Oncology
Jotamo Come, Clara Castro, Atílio Morais, Matchecane Cossa, Prassad Modcoicar, Satish Tulsidâs, Lina Cunha, Vitória Lobo, Alberto Gudo Morais, Sofia Cotton, Nuno Lunet, Carla Carrilho, Lúcio Lara Santos
PURPOSE: Eastern Africa was recently described as a high-incidence geographic area for esophageal cancer. Mozambique is included in this region. This study aimed to characterize this malignant disease at Maputo Central Hospital (MCH) to develop a global program for esophageal cancer management in Mozambique. METHODS: MCH records from between 2012 and 2016 were used to assess the clinical, pathologic, and outcome profiles of esophageal tumors. A descriptive analysis of data collected was performed...
November 2018: Journal of Global Oncology
Dianna L Ng, Edda Vuhahula, Li Zhang, Emily G Waterhouse, Kristie L White, Beatrice Paul Mushi, Msiba Selekwa Nyeriga, Godfrey Sama Philipo, Elia J Mmbaga, Sujay Sheth, Katherine Van Loon, Amie Y Lee, Ronald Balassanian
BACKGROUND: Fine-needle aspiration biopsy (FNAB) is a minimally invasive, cost-effective diagnostic tool that can be used in low-resource settings. However, adequacy and accuracy of FNAB is highly dependent on the skills of the operator and requires specialized training. Poor technique can preclude definitive diagnoses because of insufficient quality or quantity of FNAB samples. We evaluated the efficacy of an intensive training experience in Tanzania on improving ultrasound-guided FNAB techniques...
October 2018: Journal of Global Oncology
Mohamedraed Elshami, Hanan Abu Kmeil, Maymona Abu-Jazar, Ibtisam Mahfouz, Dina Ashour, Ansam Aljamal, Nada Mohareb, Reem Elbalaawi, Reem Dabbour, Jomana Ghaith, Tayseer Hasan, Meral Abdelati, Esraa Saleh, Haifa Shawwa, Reem Al-Ghazali, Ola Obaid, Loai Albarqouni, Bettina Böttcher
PURPOSE: Timely detection of breast cancer (BC) is important to reduce its related deaths. Hence, high awareness of its symptoms and risk factors is required. This study aimed to assess the awareness level of BC among females in Gaza. MATERIALS AND METHODS: A cross-sectional study was performed during September and October 2017 in Gaza, Palestine. Stratified sampling was used to recruit patients from four hospitals and seven high schools. The validated Breast Cancer Awareness Measure (BCAM) was used to assess confidence and behavior in relation to breast changes, awareness of BC symptoms and risk factors, barriers to seek medical help, and knowledge of BC screening...
October 2018: Journal of Global Oncology
Miriam L Cremer, Gabriel Conzuelo-Rodriguez, William Cherniak, Thomas Randall
Barriers to access for cervical precancer care in low-resource settings go beyond cost. Gas-based cryotherapy has emerged as the standard treatment in these areas, but there are barriers to this technology that have necessitated the development and implementation of affordable and portable alternatives. This review identifies knowledge gaps with regard to technologies primarily used in low-resource settings, including standard cryotherapy, nongas-based cryotherapy, and thermoablation. These gaps are addressed using evidence-based guidelines, patient and provider acceptability, long-term obstetric outcomes, and treatment of women with HIV infection...
October 2018: Journal of Global Oncology
Nelya Melnitchouk, Galyna Shabat, Pamela Lu, Heather Lyu, Rebecca Scully, Krystle Leung, Molly Jarman, Andrey Lukashenko, Olena O Kolesnik, Joel Goldberg, Jennifer S Davids, Ronald Bleday
PURPOSE: The incidence of colorectal cancer (CRC) is increasing worldwide, and the greatest increase is in low- to middle-income countries, such as Ukraine. Better knowledge of epidemiology of CRC in Ukraine is needed to understand how best to decrease the burden of disease. METHODS: The National Cancer Registry of Ukraine (NCRU) was queried for CRC incidence, mortality, stage, and treatment in Ukraine and assessed for regional variation from 1999 to 2015. Joinpoint analysis was used to analyze the trends...
October 2018: Journal of Global Oncology
Fahmida Shaik, Thomas S Uldrick, Tonya Esterhuizen, Anisa Mosam
PURPOSE: In sub-Saharan Africa, Kaposi sarcoma (KS) is the most common HIV-associated cancer. KS causes substantial morbidity, and treatment goals should emphasize quality of life (QOL). Antiretroviral therapy (ART) is indicated, and early chemotherapy significantly improves tumor regression. The effect of ART alone or with chemotherapy on QOL in treatment-naïve South Africans with HIV-associated KS was assessed. METHODS: KAART (Kaposi Sarcoma AIDS Anti-Retroviral Therapy) is a randomized, controlled, open-label trial of ART versus ART plus chemotherapy...
October 2018: Journal of Global Oncology
Janeesh Sekkath Veedu, Aju Mathew
No abstract text is available yet for this article.
October 2018: Journal of Global Oncology
Satish Gopal
No abstract text is available yet for this article.
October 2018: Journal of Global Oncology
Maud Hanappe, Lowell T Nicholson, Shekinah N C Elmore, Alexandra E Fehr, Jean Bosco Bigirimana, Ryan C Borg, John Butonzi, Cyprien Shyirambere, Egide Mpanumusingo, Marie O Benewe, Dan M Kanyike, Scott Triedman, Lawrence N Shulman, Christian Rusangwa, Paul H Park
PURPOSE: Low- and middle-income countries disproportionately comprise 65% of cancer deaths. Cancer care delivery in resource-limited settings, especially low-income countries in sub-Saharan Africa, is exceedingly complex, requiring multiple modalities of diagnosis and treatment. Given the vast human, technical, and financial resources required, access to radiotherapy remains limited in sub-Saharan Africa. Through 2017, Rwanda has not had in-country radiotherapy services. The aim of this study was to describe the implementation and early outcomes of the radiotherapy referral program at the Butaro Cancer Centre of Excellence and to identify both successful pathways and barriers to care...
October 2018: Journal of Global Oncology
Max S Mano, Fadil Çitaku, Don Zillioux, Marianne Waldrop
No abstract text is available yet for this article.
October 2018: Journal of Global Oncology
Asem Mansour, Amal Al-Omari, Iyad Sultan
The Syrian crisis, which started in 2011, has had a profound impact on the entire region. Jordan, with its limited resources, now has the second highest ratio of refugees to inhabitants in the world (89 to 1,000). The actual number of Syrians in Jordan is hotly contested: more than 630,776 refugees registered in November 2015 compared with 1,265,514 reported by the national census conducted at the same time. Although the numbers are slowly but steadily increasing, the number of patients with cancer who were registered by the Jordan Cancer Registry peaked in 2013 at 510 patients reported and subsequently slumped downward, which coincided with changes in funding as a result of the increasing strains on the Ministry of Health...
October 2018: Journal of Global Oncology
Henry Ddungu, Elizabeth M Krantz, Warren Phipps, Sandra Naluzze, Jackson Orem, Noah Kiwanuka, Anna Wald, Isaac Kajja
PURPOSE: Optimal decision making regarding blood transfusion for patients with cancer requires appropriate knowledge of transfusion medicine among physicians. We assessed blood transfusion knowledge, attitudes, and reported practices among physicians working at Uganda Cancer Institute (UCI). MATERIALS AND METHODS: A cross-sectional self-administered survey of UCI physicians on their knowledge, attitudes, and practices regarding blood transfusion was conducted from June to September 2014...
October 2018: Journal of Global Oncology
Evelyn Jiagge, Aisha Souleiman Jibril, Melissa Davis, Carlos Murga-Zamalloa, Celina G Kleer, Kofi Gyan, George Divine, Mark Hoenerhoff, Jessica Bensenhave, Baffour Awuah, Joseph Oppong, Ernest Adjei, Barbara Salem, Kathy Toy, Sofia Merajver, Max Wicha, Lisa Newman
PURPOSE: Population-based incidence rates of breast cancers that are negative for estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2/ neu (triple-negative breast cancer [TNBC]) are higher among African American (AA) compared with white American (WA) women, and TNBC prevalence is elevated among selected populations of African patients. The extent to which TNBC risk is related to East African versus West African ancestry, and whether these associations extend to expression of other biomarkers, is uncertain...
October 2018: Journal of Global Oncology
Andrea Castro-Sanchez, Bertha Alejandra Martinez-Cannon, Alejandra Platas, Alejandro Mohar, Alan Fonseca, Yoatzin Vega, Adrian Fimbres-Morales, Cynthia Villarreal-Garza
PURPOSE: Contraceptive counseling and adherence in young women with breast cancer (BC) is a relevant issue because chemotherapy and hormonal treatment resulting in amenorrhea do not preclude unintended pregnancies. Currently, there is limited evidence from high-income countries; however, there are no studies regarding use of contraceptives in patients with BC in Mexico. This study aimed to determine the rate of contraceptive use in young Mexican women with BC during cancer treatment, characterize their contraceptive preferences, and assess contraceptive counseling by Mexican physicians...
October 2018: Journal of Global Oncology
Mohaned O Abass, Mohamed D A Gismalla, Ahmed A Alsheikh, Moawia M A Elhassan
PURPOSE: Axillary lymph node dissection (ALND) frequently is performed as part of the surgical management of breast cancer as a therapeutic and prognostic index, but increasingly has been perceived as associated with significant complications. Data on efficacy and complications of ALND in Sudan are lacking. The aim of this study was to assess the efficacy and complications of ALND in patients with breast cancer treated with mastectomy and breast-conserving surgery. METHODS: We performed a prospective, hospital-based study in women with invasive breast cancer who underwent modified radical mastectomy or breast-conserving surgery with ALND between September 2014 and August 2015...
October 2018: Journal of Global Oncology
Emeka Odiaka, David W Lounsbury, Mohamed Jalloh, Ben Adusei, Thierno Amadou Diallo, Papa Moussa Sene Kane, Isabella Rockson, Vicky Okyne, Hayley Irusen, Audrey Pentz, Ifeoluwa Makinde, Olalekan Hafees Ajibola, Lindsay Petersen, Jo McBride, Desiree C Petersen, Sunny Mante, Ilir Agalliu, Akindele Olupelumi Adebiyi, Olufemi Popoola, Edward Yeboah, James E Mensah, Ann Hsing, Pedro Fernandez, Oseremen Aisuodionoe-Shadrach, Maureen Joffe, Elvira Singh, Serigne Magueye Gueye, Yuri Quintana, Brian Fortier, Timothy R Rebbeck, Caroline Andrews
PURPOSE: Health research in low- and middle-income countries can generate novel scientific knowledge and improve clinical care, fostering population health improvements to prevent premature death. Project management is a critical part of the success of this research, applying knowledge, skills, tools, and techniques to accomplish required goals. Here, we describe the development and implementation of tools to support a multifaceted study of prostate cancer in Africa, focusing on building strategic and operational capacity...
September 2018: Journal of Global Oncology
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