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Open Access Macedonian Journal of Medical Sciences

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https://www.readbyqxmd.com/read/28507640/histopathological-features-of-methotrexate-induced-pulmonary-lesions-in-rheumatoid-arthritis-patients-a-systematic-review-of-case-reports
#1
REVIEW
Anthony Thaniyan, Foad F A Ayman, Hyder O Mirghani, Badr A Al-Sayed, Tarig H Merghani
BACKGROUND: Methotrexate (MTX) is the most commonly used disease-modifying drug in the treatment of rheumatoid arthritis (RA); however, it causes many side effects, including pulmonary lesions. In this review, we characterised the histopathological features of MTX-induced pulmonary lesions in RA patients. AIM: We carried out an electronic search of the relevant literature published during the period from 1990 to 2016. We included only the cases with definitive histo-pathological findings caused by MTX therapy...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507639/comparative-assessment-of-women-s-reproductive-health-in-the-areas-bordering-with-the-aral-sea-region
#2
Yasminur G Turdybekova, Irina L Kopobayeva, Berikbay Zh Kultanov
AIM: We examined 435 women of Aktobe region and 328 women of South Kazakhstan region, living in areas bordering the Aral Sea region during the study and comparative assessment of the impact of climatic and anthropogenic factors of Aral region on the reproductive health of the female population. MATERIAL AND METHODS: The survey based on the comprehensive clinical-functional and laboratory studies accounting the regional and environmental ecological factors. Survey subject was the area of 2 settlements of Aktobe region and 1 settlement of South Kazakhstan region...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507638/antibiotic-utilization-in-pediatric-hospitalized-patients-a-single-center-study
#3
Hasime Qorraj Bytyqi, Rexhep Hoxha, Elton Bahtiri, Valon Krasniqi, Shaip Krasniqi
BACKGROUND: Antibiotics are among the most commonly prescribed drugs in paediatrics. In most cases, antibiotics are started on an empirical basis, without proof of a bacterial infection, either before the start of therapy or afterwards. AIM: The main objective of this study was to analyse the consumption of antibiotics in hospitalised paediatric patients. MATERIAL AND METHODS: This retrospective study investigated the consumption of antimicrobials in defined daily doses (DDDs according to the Anatomical Therapeutical Chemical/DDD index) in Pulmonology, Gastroenterology and Nephrology Departments at Pediatric Clinic of the tertiary hospital...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507637/factors-influencing-antenatal-haematinics-prescription-behaviour-of-physicians-in-calabar-nigeria
#4
Ubong Akpan, Thomas Agan, Emmanuel Monjok, Chinedu Okpara, Saturday Etuk
BACKGROUND: Routine iron and folic acid supplementation in pregnancy have been proved to be effective in reducing the prevalence and morbidities of anaemia. However, there is limited data regarding the prescription habits of physician obstetric care givers. AIM: This study set to investigate the attitudes and factors which influence the practice among physicians in University of Calabar Teaching Hospital (UCTH). MATERIAL AND METHODS: A questionnaire based cross-sectional survey was conducted among randomly recruited physician offering antenatal services between August and September 2015...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507636/influence-of-number-of-implants-and-attachment-type-on-stress-distribution-in-mandibular-implant-retained-overdentures-finite-element-analysis
#5
Mohamed I El-Anwar, Eman A El-Taftazany, Hamdy A Hamed, Mohamed A Abd ElHay
AIM: This study aimed to compare the stresses generated by using two or four root form dental implants supporting mandibular overdentures that were retained with ball and locator attachments. METHODS: Under ANSYS environment, four 3D finite element models were prepared. These models simulated complete overdentures supported by two or four implants with either ball or locator attachments as a connection mechanism. The models' components were created by CAD/CAM package then were imported to ANSYS...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507635/salivary-immunoglobulin-gene-expression-in-patients-with-caries
#6
Gema Regina Guadarrama Santín, Angel Visoso Salgado, Norma Margarita Montiel Bastida, Isaías de la Rosa Gómez, Jonnathan Guadalupe Santillán Benítez, Hugo Mendieta Zerón
BACKGROUND: Immunoglobulins mediate the host's humoral immune response are expressed in saliva. AIM: To quantify the FcαR, FcγRIIB, and FcαμR gene expression in the saliva of Mexican patients with caries in mixed and permanent dentition. SUBJECTS AND METHODS: This was a comparative cross-sectional study. mRNA was isolated from 200 μL of saliva following the RNA III Tissue Fresh-frozen protocol of the MagNA Pure LC Instrument 2.0 (Roche Diagnostics GmbH, Nederland BV) and the FcαR, FcαμR and FcγRIIB were quantified through TaqMan Assays...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507634/multi-system-complications-after-intravenous-cocaine-abuse
#7
Lidija Petkovska, Andon Chibishev, Aleksandra Stevcevska, Ivica Smokovski, Dusan Petkovski, Emilija Antova
BACKGROUND: Use and abuse of cocaine are associated with numerous adverse effects, independent of the route of administration. More severe conditions of poisoning, however, are observed after cocaine intravenous administration. AIM: We present a case of severe poisoning after violent intravenous injection of cocaine, but with a good outcome. CASE PRESENTATION: Cocaine was intravenously (i.v.) administered in 16-years old female patient as a homicide attempt...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507633/deep-vein-thrombosis-in-upper-limb-in-a-weightlifter
#8
Montserrat Pérez Pinar, Regina Pastor Toledo, Luis Broseta Viana, Julián Solís García Del Pozo
AIM: We report an unusual case of a male weightlifter with upper extremity venous thrombosis. CASE PRESENTATION: Thrombosis affecting subclavian-axillo-humeral venous trunk produced by the compression of these veins by the trained muscles of the shoulder girdle (Paget-Schroetter syndrome) has been reported. During the study, a renal carcinoma was detected. Renal carcinoma has rarely been associated with thrombosis in the upper extremities. CONCLUSION: This case shows the importance of performing a complete study to rule out malignancies in patients with unusual venous thromboembolism...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507632/visfatin-versus-flow-mediated-dilatation-as-a-marker-of-endothelial-dysfunction-in-pediatric-renal-transplant-recipients
#9
Fatina Fadel, Hafez M Bazraa, Safaa M Abdelrahman, Mohamed Gamal Shouman, Marwa Khaled Sayed, Doaa Mohamed Salah, Aliaa Ahmed Wahby, Heba F Elgebaly
BACKGROUND: Renal transplantation (RTx) is the treatment of choice for paediatric end-stage renal disease (ESRD). A major cause of morbidity and mortality after RTx is cardiovascular disease. Independent predictors of cardiovascular events were shown to constitute an endothelial dysfunction (ED). This study aims to evaluate Visfatin serum level in comparison to brachial artery flow-mediated dilatation (FMD) as a marker of endothelial dysfunction in paediatric RTx recipients. METHODS: Visfatin serum level has been evaluated in 30 patients on regular hemodialysis (HD), 36 patients post-RTx and 30 controls as a measure for ED, and has been compared to brachial artery FMD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507631/voiding-urosonography-with-second-generation-ultrasound-contrast-agent-for-diagnosis-of-vesicoureteric-reflux-first-local-pilot-study
#10
Dafina Kuzmanovska, Aleksandar Risteski, Margarita Kambovska, Tase Trpcevski, Emilija Sahpazova, Mile Petrovski
BACKGROUND: Vesicoureteric reflux (VUR) is an important association of paediatric urinary tract infection (UTI) found in 30-50% of all children presenting with first UTI. Contrast-enhanced voiding ultrasonography (ceVUS) has become an important radiation-free method for VUR detection in children. Its sensitivity in detecting VUR has greatly improved due to the development of the contrast-specific ultrasound techniques and the introduction of the second-generation ultrasound contrast agent, superseding the diagnostic accuracy of standard radiological procedures...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507630/relationship-between-gait-parameters-and-postural-stability-in-early-and-late-parkinson-s-disease-and-visual-feedback-based-balance-training-effects
#11
Mohieldin M Ahmed, Douaa M Mosalem, Aziz K Alfeeli, Ayyoub B Baqer, Doaa Youssry Soliman
BACKGROUND: Gait disorders or postural instability has been done before. However, lack of reviews has addressed the relation between gait and postural stability in Parkinson's disease (PD). AIM: The aim was to evaluate the relation between gait parameters and postural stability in early and late stages of PD. MATERIALS AND METHODS: The forty-one idiopathic PD patients were divided into two groups into a group (A) considered as early PD and group (B) considered as late ambulant PD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507629/changes-in-kinetic-parameters-of-gait-in-patients-with-supratentorial-unilateral-stroke-in-chronic-period
#12
Danche Vasileva, Nikolai Izov, Ivan Maznev, Daniela Lubenova, Marija Mihova, Velo Markovski, Carmen Nistor Cseppento
AIM: The aim of the study is to evaluate the changes of the kinetic parameters of gait in patients with supratentorial unilateral stroke in the chronic period (SUSChP). MATERIAL AND METHODS: The study was conducted with 67 patients with SUSChP (56 patients included in the experimental group - 32 men and 24 women, with duration of disease 7.8 ± 2.0 months, and 11 patients in the control group - 9 men and 2 women, with duration of disease 7.3 ± 1.5 months). To evaluate the changes in the gait were followed cadence of 6 m and 10 m and the speed of movement which are the most informative kinetic parameters...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507628/does-vitamin-d-deficiency-effect-heart-rate-variability-in-low-cardiovascular-risk-population
#13
Ahmet Nalbant, Mehmet Bulent Vatan, Perihan Varım, Ceyhun Varım, Tezcan Kaya, Ali Tamer
AIM: This study aimed to evaluate the cardiac autonomic dysfunction and the cardiac arrhythmia risk using heart rate variability parameters in subjects with vitamin D deficiency and low cardiovascular risk. MATERIAL AND METHODS: One hundred five consecutive individuals, 54 patients with low vitamin D status and 51 healthy controls were enrolled in this study. The overall cardiac autonomic tone was quantified by using various heart rate variability parameters included mean RR interval, mean Heart Rate, mean of standard deviations of intervals for 24 hours (SDNN), standard deviation of averages of intervals (SDANN), mean of standard deviation of intervals for 5 minutes (SDNNI), root mean square of difference of successive intervals (rMSSD) and the proportion of intervals differing more than 50 ms (pNN50) values...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507627/prenatally-diagnosis-and-outcome-of-fetuses-with-cardiac-rhabdomyoma-single-centre-experience
#14
Ramush Bejiqi, Ragip Retkoceri, Hana Bejiqi
BACKGROUND: Cardiac rhabdomyoma (CRs) are the most common primary tumour of the heart in infants and children. Usually are multiple and, basing on the location can cause a haemodynamic disturbance, dysrhythmias or heart failure during the fetal and early postnatal period. CRs have a natural history of spontaneous regression and are closely associated with tuberous sclerosis complex (TSC). It has an association with tuberous sclerosis (TS), and in those, the tumour may regress and disappear completely, or remain consistent in size...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507626/follow-up-of-value-of-the-intrarenal-resistivity-indices-and-different-renal-biomarkers-for-early-identification-of-diabetic-nephropathy-in-type-1-diabetic-patients
#15
Soha Abd El Dayem, Abo El Magd El Bohy, Mona Hamed, Solaf Ahmed
AIM: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN. PATIENTS AND METHODS: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507625/surveillance-of-the-most-prevalent-medical-diseases-among-pediatric-age-groups-and-evaluation-of-the-control-measures-used-at-tabuk-hospitals-saudi-arabia
#16
Ameinah Omar Al Tabbal, Seham Sulaiman Al Humedi
BACKGROUND: During the last decades, medical recordings has increased dramatically leading to more awareness of the diseases commonly affecting paediatric age groups opening a wide entrance to the prevention of possible complications and decrease its incidence. AIM: This article aims to assess the prevalence of the commonly encountered paediatric medical diseases by affected system among admitted paediatric patients of different age groups in Tabuk and to identify their burden...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507624/the-prevalence-and-risk-factors-of-osteoporosis-among-a-saudi-female-diabetic-population
#17
Ibrahim Abdulrazag Al-Homood, Iman Sheshah, Abdel Gaffar A Mohammed, Gasim I Gasim
AIM: This study aimed to assess the prevalence and determinants of osteoporosis [lumbar spine (LS) and femoral neck (FN)] among patients with type 2 diabetes at King Salman Hospital. MATERIALS AND METHODS: One hundred seventy patients with type 2 diabetes were enrolled in this cross-sectional study in the period from the 1st of January until the 1st of July 2015. Patient selection was based on self-report of the previous diagnosis by a physician, being on an antidiabetic agent, or a fasting glucose of 126 mg/dl as per the American Diabetes Association criteria...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507623/association-between-abo-and-rh-blood-groups-and-risk-of-preeclampsia-a-case-control-study-from-iran
#18
Firoozeh Aghasadeghi, Mostafa Saadat
AIM: Preeclampsia (PE) is a major cause of maternal and neonatal morbidity and mortality. There is a genetic component in the development of PE with estimated heritability around 0.47. Several studies have investigated the association between maternal ABO blood groups (OMIM 110300) and risk of PE, with contradictory results have emerged. Considering that there is no study in this filed from Iranian population, the present case-control study was carried out at Shiraz (south-west Iran)...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507622/prognostic-value-of-vascular-endothelial-growth-factor-a-in-the-prediction-of-the-tumor-aggressiveness-in-clear-cell-renal-cell-carcinoma
#19
Fahredin Veselaj, Suzana Manxhuka-Kerliu, Arber Neziri, Labinot Shahini, Shefki Xharra, Liridon Selmani, Lloreta Kerliu, Floren Kavaja
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the most predominant renal tumour with unpredictable tumour behaviour. The aim of the study is to investigate the prognostic value of vascular endothelial growth factor A (VEGF-A) expression in CCRCC and to correlate it with other histological parameters as well as with patient's survival. MATERIAL AND METHODS: Tumour blocks were taken from 40 patients with histopathology diagnosis of CCRCC and tissue block from 20 normal kidneys as a control group were examined using the immuno-histochemical staining for VEGF-A...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507621/expression-of-fgfr3-protein-and-gene-amplification-in-urinary-bladder-lesions-in-relation-to-schistosomiasis
#20
Olfat Hammam, Tarek Aboushousha, Ali El-Hindawi, Hosni Khairy, Heba Khalil, Amira Kamel, Maha Akl, Ahmed Abdel-Hady, Mona Magdy, Mohamed Badawy, Amr El Kholy, Khalid Al Osili, Nora Kamel, Shady Anis, Tarek El Leithy
BACKGROUND: Bladder cancer represents the fifth most common malignancy worldwide and a major cause of cancer-related morbidity and death. Incidence and mortality rates have remained relatively constant over the past four decades. Urothelial bladder cancers have identified multiple risk factors. AIM: We aimed at evaluating the expression of the FGFR3 protein and gene amplification in the urothelial cells of neoplastic and non-neoplastic urothelial lesions of the urinary bladder, and correlation with tumour grade, stage and associated bilharziasis...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
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