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Current Research in Translational Medicine

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https://www.readbyqxmd.com/read/27939460/exploring-the-brain-skin-connection-leads-and-lessons-from-the-hair-follicle
#1
R Paus
Research into how the central nervous system (CNS) and the skin of mammals are physiologically connected and how this "brain-skin connection" may be therapeutically targeted in clinical medicine has witnessed a renaissance. A key element in this development has been the discovery that mammalian skin and its appendages, namely human scalp hair follicles (HFs), not only are important, long-underestimated target tissues for classical neurohormones, neurotrophins and neuropeptides, but also are eminent peripheral tissue sources for the production and/or release of these neuromediators...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939459/molecular-mechanisms-of-pruritus
#2
REVIEW
J Meng, M Steinhoff
Pruritus is an unpleasant sensation that evokes the urgent desire to scratch. It is a symptom derived from many nervous system disorders that affects a large population of humans and is treated by a variety of pharmacological agents with variable access. Chronic itch is a huge unmet health problem which affect upward 20% of people worldwide. The mechanisms underlying the chronic pruritus are complex. Studies of the neurobiology, neurophysiology and cellular biology of itch have gradually been clarifying the mechanism of chronic itch both peripherally and centrally...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939458/evidence-for-physiological-and-pathological-roles-for-sensory-nerves-in-the-microvasculature-and-skin
#3
X Kodji, A A Aubdool, S D Brain
This review highlights the progress from the initial finding of neurogenic inflammation up to the most recent development in the field of sensory nerves research, focusing on their roles in the microvasculature and the skin. Recent discovery of Transient Receptor Potential (TRP) channels highlight their important roles in detecting a range of environmental stimuli, including chemical and temperature. This provides us novel mechanisms for driving neurogenic inflammation upstream of neuropeptide release in addition to promising potential therapeutic targets in various diseases, including pain, itching and skin inflammation...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939457/skin-fibrosis-models-and-mechanisms
#4
N N Do, S A Eming
Matrix synthesis, deposition and remodeling are complex biological processes that are critical in development, maintenance of tissue homeostasis and repair of injured tissues. Disturbances in the regulation of these processes can result in severe pathological conditions which are associated with tissue fibrosis as e.g. in Scleroderma, cutaneous Graft-versus-Host-Disease, excessive scarring after trauma or carcinogenesis. Therefore, finding efficient treatments to limit skin fibrosis is of major clinical importance...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939456/modelling-atopic-dermatitis-during-the-morphogenetic-process-involved-in-reconstruction-of-a-human-epidermis
#5
É De Vuyst, A Mound, C Lambert de Rouvroit, Y Poumay
Most crucial role of epidermis is to maintain efficient barrier between the organism and its environment. This barrier is however perturbed in inflammatory skin conditions like atopic dermatitis (AD), one common chronic disease. This review depicts characteristics of a model intending to reproduce epidermal features of AD in vitro. Firstly, methyl-β-cyclodextrin (MβCD) during reconstruction of epidermis was used to deplete cholesterol from plasma membrane because this condition reproduces characteristics of AD at transcriptomic level in monolayer cultures...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939455/the-role-of-myofibroblasts-in-wound-healing
#6
B Hinz
The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair (fibrosis). Chronic wounds are a tremendous burden for patients and global healthcare systems and are on the rise due to their increasing incidence with age and diabetes. Curiously, these same risk factors also sign responsible for the development of hypertrophic scarring and organ fibrosis. Activated repair cells - myofibroblasts - are the main producers and organizers of extracellular matrix which is needed to restore tissue integrity after injury...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939454/skin-and-brain-repair-new-prospects-in-the-life-of-a-couple
#7
EDITORIAL
F Bonté, A Desmoulière
No abstract text is available yet for this article.
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27939453/tlr3-and-skin-features
#8
EDITORIAL
F Morinet
No abstract text is available yet for this article.
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765278/oxygen-a-regulator-of-viral-gene-expression
#9
F Morinet, M Parent, C Lebbé, S Pillet, M Koken, C Capron
No abstract text is available yet for this article.
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765277/ovarian-cancer-presenting-as-an-axillary-mass-case-series-and-literature-review
#10
REVIEW
B Ilhan, B Kılıç, H Karanlik
AIM: Ovarian cancer is a common cause of death in women worldwide. The purpose of this article was to report a case series and draw physicians' attention to the benefits of histpathologic techniques in determining uncommon metastatic diseases. METHODS: In this study, we report a case series of axillary involvement of ovarian cancer in 6 patients. The data were collected between 2006 and 2015 by analyzing patient's characteristics, and biochemical and immunohistochemical features...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765276/the-role-of-toll-like-receptor-9-in-gynecologic-cancer
#11
E Fehri, E Ennaifer, R Bel Haj Rhouma, L Guizani-Tabbane, I Guizani, S Boubaker
Toll-like receptor 9 (TLR9) plays a major role in the fight against DNA viruses infections. Despite its antitumor properties, inappropriate activation of TLR9 during chronic inflammation may cause the activation of transcription factors inducing pro-cancerous activities. Thus, the relationship between TLR9 and cancer remains highly confrontational especially in gynecological cancers and cervical cancer induced by viruses. In this review, we focus on the beneficial and detrimental role of TLR9 in gynecological carcinogenesis...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765275/quantitative-study-on-morphology-of-calcified-cartilage-zone-in-oarsi-0%C3%A2-4-cartilage-from-osteoarthritic-knees
#12
B Deng, F Wang, L Yin, C Chen, L Guo, H Chen, X Gong, Y Li, L Yang
OBJECTIVE: To observe the morphological feature of calcified cartilage zone (CCZ) in mild to moderate degeneration of cartilages from patients with knee osteoarthritis (OA), revealing the pattern of CCZ during OA progression and its correlation to the surrounding structures. METHODS: Osteochondral specimens were collected from the center of the lateral tibial plateau of 42 OA patients undergoing total knee replacement. Sections were stained with hematoxylin-eosin and Safranin-O/Fast green...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765274/-18-f-fdg-labelling-of-hematopoietic-stem-cells-dynamic-study-of-bone-marrow-homing-by-pet-ct-imaging-and-impact-on-cell-functionality
#13
L Faivre, M Chaussard, L Vercellino, V Vanneaux, B Hosten, K Teixera, V Parietti, P Merlet, L Sarda-Mantel, N Rizzo-Padoin, J Larghero
PURPOSE OF THE STUDY: After transplantation, cord blood (CB) hematopoietic stem and progenitor cells (HSPCs) are able to home to the bone marrow niche and to reconstitute the hematopoietic system. PET-CT imaging may be a useful method to monitor this parameter in different conditions. The aim of our study was to set up an efficient method for HSPC radiolabelling with [(18)F] fluorodeoxyglucose ((18)F-FDG) and to follow early HSPC homing through PET-CT in mice. MATERIALS AND METHODS: Purified CB HSPCs were radiolabelled with (18)F-FDG at 37° C with various conditions of cell concentration, incubation time and radioactivity concentration in order to define the in vitro condition that allows both sufficient (18)F-FDG uptake to get high quality PET imaging, and preservation of HSPC viability and functional properties during 3h after radiolabelling...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765273/distinctive-roles-of-pkc-delta-isozyme-in-platelet-function
#14
Y Zaid, N Senhaji, Y Darif, K Kojok, M Oudghiri, A Naya
Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765272/major-bleeding-complications-in-patients-treated-with-direct-oral-anticoagulants-one-year-observational-study-in-a-paris-hospital
#15
L Deville, M Konan, A Hij, L Goldwirt, O Peyrony, F Fieux, P Faure, I Madelaine, S Villiers, D Farge-Bancel, C Frère
Direct oral anticoagulants (DAOC) are indicated for the treatment of venous thromboembolism and the prevention of stroke or systemic embolism in patients with non-valvular atrial fibrillation. Given their advantages and friendly use for patient, the prescription of long term DOAC therapy has rapidly increased both as first line treatment while initiating anticoagulation and as a substitute to vitamins K antagonist (VKA) in poorly controlled patients. However, DOAC therapy can also be associated with significant bleeding complications, and in the absence of specific antidote at disposal, treatment of serious hemorrhagic complications under DOAC remains complex...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765271/down-regulation-of-tumor-suppressor-pdcd4-expression-in-endometrium-of-adenomyosis-patients
#16
Y Liu, X Tan, Z Wang, Y Li, M Gao, Y Li, Z Fang, Y Sun, L Zhang, X Wang, Z Wei
OBJECTIVE: Adenomyosis is a common benign gynecological disease which has some malignant behaviors. Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor gene which lowly expresses in various cancers. However, the expression status of PDCD4 in endometrium of adenomyosis patients has not been investigated. The aim of this study is to assess the expression levels of PDCD4 in endometrium of normal controls and adenomyosis patients. METHODS: The expression of PDCD4 in endometrium of normal controls and eutopic or ectopic endometrium of patients with adenomyosis was evaluated with quantitative real-time PCR, western blot and immunohistochemistry...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765270/ex-vivo-gene-therapy-in-france
#17
F Morinet, J Larghero
No abstract text is available yet for this article.
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316395/mesenchymal-stem-cells-for-treating-autoimmune-diseases-the-chinese-experience-from-lab-to-clinics
#18
REVIEW
J Liang, D Wang, F Dominique, L Sun
Autoimmune diseases are a group of chronic inflammatory conditions diseases characterized by aberrant activation of the immune system involving either cells or antibodies directed against normal tissues. The current conventional strategies, notably corticosteroids and immunosuppressors, are responsible for high treatment-related morbidity and are still associated with significant disease and treatment-related mortality. Recently, experimental and clinical data has suggested that mesenchymal stem cell transplantation would be a promising therapy strategy for the treatment of autoimmune diseases...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316394/resetting-the-immune-response-after-autologous-hematopoietic-stem-cell-transplantation-for-autoimmune-diseases
#19
REVIEW
L C M Arruda, E Clave, H Moins-Teisserenc, C Douay, D Farge, A Toubert
Autologous hematopoietic stem cell transplantation (AHSCT) is currently investigated as treatment for severe and refractory autoimmune diseases, such as multiple sclerosis (MS), systemic sclerosis (SSc), Crohn's disease (CD) and systemic lupus erythematosus. Randomized clinical trials in MS, SSc and CD have shown the efficacy of AHSCT to promote control of disease activity and progression, when compared to conventional treatment. The use of high dose immunosuppressive conditioning is essential to eliminate the autoimmune repertoire, and the re-infusion of autologous hematopoietic stem cells avoids long-term leucopenia by reconstitution of both immune and hematological systems...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316393/stem-cells-for-the-treatment-of-heart-failure
#20
REVIEW
P Menasché, V Vanneaux
Stem cell-based therapy is currently tested in several trials of chronic heart failure. The main question is to determine how its implementation could be extended to standard clinical practice. To answer this question, it is helpful to capitalize on the three main lessons drawn from the accumulated experience, both in the laboratory and in the clinics. Regarding the cell type, the best outcomes seem to be achieved by cells the phenotype of which closely matches that of the target tissue. This argues in favor of the use of cardiac-committed cells among which the pluripotent stem cell-derived cardiac progeny is particularly attractive...
April 2016: Current Research in Translational Medicine
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