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Current Research in Translational Medicine

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https://www.readbyqxmd.com/read/29456197/clinical-usefulness-and-accuracy-of-polymerase-chain-reaction-in-the-detection-of-bacterial-meningitis-agents-in-pediatric-cerebrospinal-fluid
#1
M Nour, A Alaidarous
Bacterial meningitis poses enormous healthcare challenges due to a high mortality, morbidity and sequelae. Neisseria (N.) meningitidis, Haemophilus (H.) influenzae, Streptococcus (S.) pneumoniae and S. agalactiae remain among the most prevalent infectious agents that cause bacterial meningitis in children. The objective of this study was the simultaneous detection of these pathogens in suspected cerebrospinal fluid (CSF) by using multiplex polymerase chain reaction (mPCR) and compare PCR results with standard diagnostics currently used in clinical practice...
February 15, 2018: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29287698/quantification-of-the-first-who-international-standard-for-bk-virus-dna-by-an-automated-pcr-assay
#2
LETTER
I Engelmann, E K Alidjinou, J-M Pouillaude, J Ogiez, A Dewilde, D Hober
No abstract text is available yet for this article.
December 26, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29277562/evaluating-the-expression-level-of-co-stimulatory-molecules-cd-80-and-cd-86-in-different-types-of-colon-polyps
#3
N Peyravian, E Gharib, A Moradi, M Mobahat, P Tarban, P Azimzadeh, E Nazemalhosseini-Mojarad, H Asadzadeh Aghdaei
PURPOSE OF THE STUDY: Co-stimulatory molecules CD80 and CD86 are the members of B7 family, which stimulate the T lymphocytes in response to the malignant colon polyps. However, the expression of these molecules is depressed in cancers. In the present study, the transcription levels of CD80 and CD86 genes in the colon polyps (Precancerous lesions) and its association with the clinical features were examined. PATIENTS AND METHODS: Forty-nine biopsies samples from patients with the colorectal polyps and 10 healthy subjects were collected by the colonoscopy...
December 22, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29274707/high-mybl2-expression-and-transcription-regulatory-activity-is-associated-with-poor-overall-survival-in-patients-with-hepatocellular-carcinoma
#4
Z Guan, W Cheng, D Huang, A Wei
PURPOSE: In this study, we aimed to assess the association between MYBL2 expression/transcription regulatory activity (TRA) and overall survival (OS) in patients with primary hepatocellular carcinoma (HCC) and to explore the factors related to B-Myb TRA. MATERIALS AND METHODS: Bioinformatic analysis was performed based on data from the cancer genome atlas-liver hepatocellular carcinoma (TCGA-LIHC) and the human protein atlas (HPA). RESULTS: The death group in TCGA-LIHC had significantly higher MYBL2 RNA and exon expression than the censor group...
December 20, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29132902/histopathological-assessment-of-primary-osteoarthritic-knees-in-large-patient-cohort-reveal-the-possibility-of-several-potential-patterns-of-osteoarthritis-initiation
#5
V P Mantripragada, N S Piuzzi, T Zachos, N A Obuchowski, G F Muschler, R J Midura
OBJECTIVE: The two main objectives of the study include (1) Test the hypothesis that the lateral femoral condyle (LFC) in patients with primary OA and varus knees undergoing total knee arthroplasty (TKA) can be used as a model to better characterize varying histological features of human OA, (2) Correlate characteristic OA features using the established histopathological scoring systems (HHGS and OARSI) to understand potential histopathological patterns of OA initiation. DESIGN: Two osteochondral specimens (4×4×8mm) were collected from fifty patient's LFC at the time of TKA (total 100 specimens), who presented preserved lateral knee compartment with joint space width>2mm...
November 10, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29128203/study-of-correlation-between-genetic-variants-in-three-microrna-genes-hsa-mir-146a-hsa-mir-502-binding-site-hsa-mir-27a-and-breast-cancer-risk
#6
S Parchami Barjui, S Reiisi, S O Ebrahimi, B Shekari
BACKGROUND AND AIM: MicroRNAs (miRNAs) represent noncoding RNAs that play a role in the gene regulation of oncogenes and tumor suppressors. Single nucleotide polymorphisms (SNPs) in miRNA genes are associated with risk of cancer. Some of these SNPs are more common including rs2910164 in the miR-146a, rs895819 in the miR-27a, and rs2910164 in the miR-502 binding site of the SET8. Our aim was to investigate the association between these polymorphisms and the risk of breast cancer in an Iranian population...
November 8, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29132903/progressive-multifocal-leukoencephalopathy-in-patients-receiving-rituximab-and-cyclophosphamide-after-haplo-identical-t-cell-replete-transplantation-and-review-of-the-literature
#7
REVIEW
R Salem, R Massoud, S S Kanj, M Hamdan, R Salman, A Bazarbachi, J El-Cheikh
John Cunningham virus (JCV) reactivation, occurring mainly in immunocompromised patients, leads to progressive multifocal leukoencephalopathy, an uncommon but lethal disease. JCV reactivation after T-cell replete haploidentical stem cell transplantation, in the pre-cyclophosphamide era, is poorly represented in the literature. We therefore describe two cases of acute myeloid leukemia who developed JCV reactivation after receiving cyclophosphamide and rituximab post haploidentical stem cell transplantation, and review the literature, aiming to a better understanding of the disease course and its risk factors...
November 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29122584/how-to-build-an-allogeneic-hematopoietic-cell-transplant-unit-in-2016-proposal-for-a-practical-framework
#8
M Crysandt, I Yakoub-Agha, P Reiß, S Theisen, G Silling, P Glatte, E Nelles, S Lemmen, T H Brümmendorf, U Kontny, E Jost
Allogeneic hematopoietic cell transplantation is part of the standard of care for many hematological diseases. Over the last decades, significant advances in patient and donor selection, conditioning regimens as well as supportive care of patients undergoing allogeneic hematopoietic cell transplantation leading to improved overall survival have been made. In view of many new treatment options in cellular and molecular targeted therapies, the place of allogeneic transplantation in therapy concepts must be reviewed...
November 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28916449/bio-scaffolds-in-organ-regeneration-clinical-potential-and-current-challenges
#9
REVIEW
S Yesmin, M B Paget, H E Murray, R Downing
Cadaveric organ transplantation represents the definitive treatment option for end-stage disease but is restricted by the shortage of clinically-viable donor organs. This limitation has, in part, driven current research efforts for in vitro generation of transplantable tissue surrogates. Recent advances in organ reconstruction have been facilitated by the re-purposing of decellularized whole organs to serve as three-dimensional bio-scaffolds. Notably, studies in rodents indicate that such scaffolds retain native extracellular matrix components that provide appropriate biochemical, mechanical and physical stimuli for successful tissue/organ reconstruction...
September 12, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28919193/association-analysis-of-genetic-variants-with-metabolic-syndrome-components-in-the-moroccan-population
#10
F Lakbakbi El Yaagoubi, H Charoute, I Morjane, H Sefri, H Rouba, A Ainahi, M Kandil, H Benrahma, A Barakat
This study aimed to analyze the association between UBE2E2, G6PC2, PROX1, DUSP9, ADCY5 and APOC3 polymorphisms and the risk of metabolic syndrome (MetS) in Moroccan patients. The study was applied on 316 unrelated individuals from Morocco, 177 MetS patients and 139 controls. The metabolic syndrome was diagnosed according to the International Diabetes Federation (IDF) criteria. All subjects were genotyped for the following polymorphisms: rs7612463 (UBE2E2), rs560887 (G6PC2), rs340874 (PROX1), rs5945326 (DUSP9), rs11708067 (ADCY5) and rs5128 (APOC3) using TaqMan allelic discrimination assay and PCR-RFLP...
September 11, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28988743/fludarabine-based-reduced-intensity-regimen-for-matched-related-donor-hematopoietic-stem-cell-transplantation-in-acquired-severe-aplastic-anemia
#11
K M Ghanem, M A Kharfan-Dabaja, H El-Solh, N Harris, N Kreidieh, R Nehme, S A Muwakkit, R Saab, A Bazarbachi, M R Abboud
Different conditioning regimens have been evaluated in matched-related donor allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acquired severe aplastic anemia (SAA) with varying results. In this manuscript, we report our experience with fludarabine (120mg/m(2)), very low dose cyclophosphamide (1200mg/m(2)) and antithymocyte globulin (7.5mg/kg). Low dose total body irradiation (2Gy) was added to the conditioning regimen for patients older than 15 years. Nineteen patients (median age 23years) underwent transplant between 2008 and 2015...
September 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28988742/chimeric-antigen-receptor-t-cell-therapy-for-hematological-malignancies-and-solid-tumors-clinical-data-to-date-current-limitations-and-perspectives
#12
REVIEW
J Gauthier, I Yakoub-Agha
Progress in our understanding of basic immunology along with the advent of bioengineering technologies have made possible the production of human T-cells expressing Chimeric Antigen Receptors (CAR T-cells). These CAR T-cells are designed to target specific antigens presented by cancer cells. Once CARs are bound to these antigens, CAR T-cells get activated and can initiate potent anti-tumor effects. We will here overview the bioengineering advances which made possible the clinical application of CAR T-cell therapy...
September 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28689016/long-term-follow-up-of-invasive-aspergillosis-in-allogeneic-stem-cell-transplantation-recipients-and-leukemia-patients-differences-in-risk-factors-and-outcomes
#13
S Bonnet, R Duléry, K Regany, M Bouketouche, L Magro, V Coiteux, S Alfandari, C Berthon, B Quesnel, I Yakoub-Agha
Antifungal prophylaxis (AP) has dramatically changed the epidemiology of invasive aspergillosis (IA). To better understand the differences in terms of clinical significance of IA between allogeneic stem cell transplantation (allo-SCT) recipients and patients treated for leukemia, we report a single-center study of 735 unselected consecutive patients treated between 2000 and 2004, before the era of systematic AP. Probable or confirmed IA were observed in 29 patients (2008 EORTC/MSG criteria), including 7/235 undergoing allo-SCT (5...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28687223/how-to-prevent-relapse-after-allogeneic-hematopoietic-stem-cell-transplantation-in-patients-with-acute-leukemia-and-myelodysplastic-syndrome
#14
REVIEW
N Yafour, F Beckerich, C E Bulabois, P Chevallier, E Daguindau, C Dumesnil, T Guillaume, A Huynh, S Masouridi Levrat, A L Menard, C Pautas, X Poiré, A Ravinet, M Michallet, A Bazarbachi
Disease relapse remains the first cause of mortality of hematological malignancies after allogeneic hematopoietic stem cell transplantation (allo-HCT). The risk of recurrence is elevated in acute myeloid leukemia (AML) patients with high-risk cytogenetic or molecular abnormalities, as well as when allo-HCT is performed in patients with refractory hematological malignancies or with persistent molecular or radiological (PET-CT scan) residual disease. For high risk AML and myelodysplasia (MDS), a post transplant maintenance strategy is possible, using hypomethylating agents or tyrosine kinase inhibitors (TKI) anti-FLT3 when the target is present...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28684265/prognostic-significance-of-preoperative-albumin-to-globulin-ratio-in-patients-with-cholangiocarcinoma
#15
Q Lin, Z-H Lin, J Chen, J-X Lin, X Li, J-R Jiang, X-K Ma, D-H Wu, Z-H Chen, M Dong, L Wei, T-T Wang, D-Y Ruan, Z-X Lin, J-Y Wen, X-Y Wu, M-S Huang
BACKGROUND: This study aimed to assess the prognostic value of the serum albumin to globulin ratio (AGR) in cholangiocarcinoma patients after surgery. METHODS: We retrospectively enrolled 123 cholangiocarcinoma patients who underwent surgical treatment between June 2003 and September2014 at the Third Affiliated Hospital of Sun Yat-sen University. Univariate and multivariate analyses using the Cox regression model were performed to determine the prognostic value of AGR...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28629734/immunohistochemical-and-genetic-exploration-of-incompatible-a-blood-group-antigen-expression-in-invasive-micropapillary-breast-carcinoma-a-case-report
#16
S Zouine, Z Orfi, K Kojok, S Benayad, Y Zaid, F Marnissi, N Habti
INTRODUCTION: Invasive Micropapillary Carcinoma (IMPC) of the breast is a relatively rare subtype of invasive ductal carcinoma and represents the most inherently aggressive form. Expression of incompatible blood group A antigen in cancer of type O patients has been reported in several types of cancer, however, the biosynthetic mechanism and the genetic basis remain unclear until today. The aim of the present case report study was to evaluate the expression of incompatible blood group A antigen and to identify the genetic basis of this expression in IMPC of the breast...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28619392/platelet-satellitism-in-autoimmune-hemolytic-anemia
#17
REVIEW
I Ghariani, N Braham, S Hamzaoui, L Bekir
Platelet satellitism is a rare phenomenon observed in blood smears obtained from blood anticoagulated with EDTA with an estimated frequency at 0.008%. It is characterized by platelet rosetting around neutrophils and in rare cases around other blood cells, which may causes pseudothrombocytopenia. Our case involves a 26-year-old female patient with autoimmune hemolytic anemia (AIHA). Blood smear with EDTA as an anticoagulant had platelet satellitism whereas the phenomenon was not observed in tubes with different anticoagulants (citrate, heparin) and capillary blood...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28466824/mesenchymal-stem-cell-therapy-in-parkinson-s-disease-animal-models
#18
REVIEW
A Gugliandolo, P Bramanti, E Mazzon
Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, and as a consequence, by decreased dopamine levels in the striatum. Currently available therapies are not able to stop or reverse the progression of the disease. A novel therapeutic approach is based on cell therapy with stem cells, in order to replace degenerated neurons. Among stem cells, mesenchymal stem cells seemed the most promising thanks to their capacities to differentiate toward dopaminergic neurons and to release neurotrophic factors...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28447938/low-serum-selenium-concentrations-in-french-patients-with-measles
#19
M Garcia, A Pineau, O Guillard, S Ragot, N Lévêque, G Agius
OBJECTIVE: Selenium deficiency adversely affects the clinical outcome of measles in the tropics. In developed countries, serum selenium level has never been investigated during acute measles. The aim of this study was to determine serum selenium concentrations in French patients with acute measles and to seek correlations with clinical and virological findings. PATIENTS AND METHODS: We studied serum selenium concentrations in 94 French patients with acute measles and in 99 healthy controls matched for age and sex...
April 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28340697/hypoxia-inducible-factor-one-alpha-and-human-viral-pathogens
#20
REVIEW
F Morinet, M Parent, S Pillet, M Koken, C Lebbé, C Capron
If the oxygen tension level is 21% in ambient air, it is only between 14% and 1% in vivo. Consequently, viral pathogens are exposed and must adapt to these fluctuating oxygen levels to colonize the host and cause diseases. The problem is that for many years, the virological studies have been performed at 21% oxygen levels and consequently this is a real handicap to have a correct view of the mechanistic aspects of human viral infections. In this brief review, we describe for some selected examples the interactions of human viruses with this relative hypoxia observed in vivo...
January 2017: Current Research in Translational Medicine
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