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Current Research in Translational Medicine

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https://www.readbyqxmd.com/read/27765278/oxygen-a-regulator-of-viral-gene-expression
#1
F Morinet, M Parent, C Lebbé, S Pillet, M Koken, C Capron
No abstract text is available yet for this article.
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765277/ovarian-cancer-presenting-as-an-axillary-mass-case-series-and-literature-review
#2
REVIEW
B Ilhan, B Kılıç, H Karanlik
AIM: Ovarian cancer is a common cause of death in women worldwide. The purpose of this article was to report a case series and draw physicians' attention to the benefits of histpathologic techniques in determining uncommon metastatic diseases. METHODS: In this study, we report a case series of axillary involvement of ovarian cancer in 6 patients. The data were collected between 2006 and 2015 by analyzing patient's characteristics, and biochemical and immunohistochemical features...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765276/the-role-of-toll-like-receptor-9-in-gynecologic-cancer
#3
E Fehri, E Ennaifer, R Bel Haj Rhouma, L Guizani-Tabbane, I Guizani, S Boubaker
Toll-like receptor 9 (TLR9) plays a major role in the fight against DNA viruses infections. Despite its antitumor properties, inappropriate activation of TLR9 during chronic inflammation may cause the activation of transcription factors inducing pro-cancerous activities. Thus, the relationship between TLR9 and cancer remains highly confrontational especially in gynecological cancers and cervical cancer induced by viruses. In this review, we focus on the beneficial and detrimental role of TLR9 in gynecological carcinogenesis...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765275/quantitative-study-on-morphology-of-calcified-cartilage-zone-in-oarsi-0%C3%A2-4-cartilage-from-osteoarthritic-knees
#4
B Deng, F Wang, L Yin, C Chen, L Guo, H Chen, X Gong, Y Li, L Yang
OBJECTIVE: To observe the morphological feature of calcified cartilage zone (CCZ) in mild to moderate degeneration of cartilages from patients with knee osteoarthritis (OA), revealing the pattern of CCZ during OA progression and its correlation to the surrounding structures. METHODS: Osteochondral specimens were collected from the center of the lateral tibial plateau of 42 OA patients undergoing total knee replacement. Sections were stained with hematoxylin-eosin and Safranin-O/Fast green...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765274/-18-f-fdg-labelling-of-hematopoietic-stem-cells-dynamic-study-of-bone-marrow-homing-by-pet-ct-imaging-and-impact-on-cell-functionality
#5
L Faivre, M Chaussard, L Vercellino, V Vanneaux, B Hosten, K Teixera, V Parietti, P Merlet, L Sarda-Mantel, N Rizzo-Padoin, J Larghero
PURPOSE OF THE STUDY: After transplantation, cord blood (CB) hematopoietic stem and progenitor cells (HSPCs) are able to home to the bone marrow niche and to reconstitute the hematopoietic system. PET-CT imaging may be a useful method to monitor this parameter in different conditions. The aim of our study was to set up an efficient method for HSPC radiolabelling with [(18)F] fluorodeoxyglucose ((18)F-FDG) and to follow early HSPC homing through PET-CT in mice. MATERIALS AND METHODS: Purified CB HSPCs were radiolabelled with (18)F-FDG at 37° C with various conditions of cell concentration, incubation time and radioactivity concentration in order to define the in vitro condition that allows both sufficient (18)F-FDG uptake to get high quality PET imaging, and preservation of HSPC viability and functional properties during 3h after radiolabelling...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765273/distinctive-roles-of-pkc-delta-isozyme-in-platelet-function
#6
Y Zaid, N Senhaji, Y Darif, K Kojok, M Oudghiri, A Naya
Platelet activation is a complex balance of positive and negative signaling pathways. Several protein kinase C (PKC) isoforms are expressed in human platelets. They are a major regulator of platelet granule secretion, activation and aggregation activity. One of those isoforms is the PKCδ isozyme, it has a central yet complex role in platelets such as opposite signaling functions depending on the nature of the agonist, it concentration and pathway. In fact, it has been shown that PKCδ has an overall negative influence on platelet function in response to collagen, while, following PAR stimulation, PKCδ has a positive effect on platelet function...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765272/major-bleeding-complications-in-patients-treated-with-direct-oral-anticoagulants-one-year-observational-study-in-a-paris-hospital
#7
L Deville, M Konan, A Hij, L Goldwirt, O Peyrony, F Fieux, P Faure, I Madelaine, S Villiers, D Farge-Bancel, C Frère
Direct oral anticoagulants (DAOC) are indicated for the treatment of venous thromboembolism and the prevention of stroke or systemic embolism in patients with non-valvular atrial fibrillation. Given their advantages and friendly use for patient, the prescription of long term DOAC therapy has rapidly increased both as first line treatment while initiating anticoagulation and as a substitute to vitamins K antagonist (VKA) in poorly controlled patients. However, DOAC therapy can also be associated with significant bleeding complications, and in the absence of specific antidote at disposal, treatment of serious hemorrhagic complications under DOAC remains complex...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765271/down-regulation-of-tumor-suppressor-pdcd4-expression-in-endometrium-of-adenomyosis-patients
#8
Y Liu, X Tan, Z Wang, Y Li, M Gao, Y Li, Z Fang, Y Sun, L Zhang, X Wang, Z Wei
OBJECTIVE: Adenomyosis is a common benign gynecological disease which has some malignant behaviors. Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor gene which lowly expresses in various cancers. However, the expression status of PDCD4 in endometrium of adenomyosis patients has not been investigated. The aim of this study is to assess the expression levels of PDCD4 in endometrium of normal controls and adenomyosis patients. METHODS: The expression of PDCD4 in endometrium of normal controls and eutopic or ectopic endometrium of patients with adenomyosis was evaluated with quantitative real-time PCR, western blot and immunohistochemistry...
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27765270/ex-vivo-gene-therapy-in-france
#9
F Morinet, J Larghero
No abstract text is available yet for this article.
July 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316395/mesenchymal-stem-cells-for-treating-autoimmune-diseases-the-chinese-experience-from-lab-to-clinics
#10
REVIEW
J Liang, D Wang, F Dominique, L Sun
Autoimmune diseases are a group of chronic inflammatory conditions diseases characterized by aberrant activation of the immune system involving either cells or antibodies directed against normal tissues. The current conventional strategies, notably corticosteroids and immunosuppressors, are responsible for high treatment-related morbidity and are still associated with significant disease and treatment-related mortality. Recently, experimental and clinical data has suggested that mesenchymal stem cell transplantation would be a promising therapy strategy for the treatment of autoimmune diseases...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316394/resetting-the-immune-response-after-autologous-hematopoietic-stem-cell-transplantation-for-autoimmune-diseases
#11
REVIEW
L C M Arruda, E Clave, H Moins-Teisserenc, C Douay, D Farge, A Toubert
Autologous hematopoietic stem cell transplantation (AHSCT) is currently investigated as treatment for severe and refractory autoimmune diseases, such as multiple sclerosis (MS), systemic sclerosis (SSc), Crohn's disease (CD) and systemic lupus erythematosus. Randomized clinical trials in MS, SSc and CD have shown the efficacy of AHSCT to promote control of disease activity and progression, when compared to conventional treatment. The use of high dose immunosuppressive conditioning is essential to eliminate the autoimmune repertoire, and the re-infusion of autologous hematopoietic stem cells avoids long-term leucopenia by reconstitution of both immune and hematological systems...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316393/stem-cells-for-the-treatment-of-heart-failure
#12
REVIEW
P Menasché, V Vanneaux
Stem cell-based therapy is currently tested in several trials of chronic heart failure. The main question is to determine how its implementation could be extended to standard clinical practice. To answer this question, it is helpful to capitalize on the three main lessons drawn from the accumulated experience, both in the laboratory and in the clinics. Regarding the cell type, the best outcomes seem to be achieved by cells the phenotype of which closely matches that of the target tissue. This argues in favor of the use of cardiac-committed cells among which the pluripotent stem cell-derived cardiac progeny is particularly attractive...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316392/human-induced-pluripotent-stem-cells-a-disruptive-innovation
#13
REVIEW
J De Vos, J Bouckenheimer, C Sansac, J-M Lemaître, S Assou
This year (2016) will mark the 10th anniversary of the discovery of induced pluripotent stem cells (iPSCs). The finding that the transient expression of four transcription factors can radically remodel the epigenome, transcriptome and metabolome of differentiated cells and reprogram them into pluripotent stem cells has been a major and groundbreaking technological innovation. In this review, we discuss the major applications of this technology that we have grouped in nine categories: a model to study cell fate control; a model to study pluripotency; a model to study human development; a model to study human tissue and organ physiology; a model to study genetic diseases in a dish; a tool for cell rejuvenation; a source of cells for drug screening; a source of cells for regenerative medicine; a tool for the production of human organs in animals...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316391/bone-regeneration-strategies-with-bone-marrow-stromal-cells-in-orthopaedic-surgery
#14
REVIEW
J Stanovici, L-R Le Nail, M A Brennan, L Vidal, V Trichet, P Rosset, P Layrolle
Bone is the most transplanted tissue human with 1 million procedures every year in Europe. Surgical interventions for bone repair are required for varied reasons such as trauma resulting non-union fractures, or diseases including osteoporosis or osteonecrosis. Autologous bone grafting is the gold standard in bone regeneration but it requires a second surgery with associated pain and complications, and is also limited by harvested bone quantity. Synthetic bone substitutes lack the osteoinductive properties to heal large bone defects...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316390/haematopoietic-stem-cell-transplantation-in-autoimmune-diseases-from-basic-science-to-clinical-practice
#15
REVIEW
P J Kelsey, M-C Oliveira, M Badoglio, B Sharrack, D Farge, J A Snowden
Based on animal studies and serendipitous clinical cases, haematopoietic stem cell transplantation (HSCT) has been used since 1995 as a specific treatment for patients with severe treatment-resistant autoimmune disease (ADs). Despite other clinical developments for autoimmune diseases, including biological therapies, there has been an ongoing requirement for HSCT in some diseases and several thousand procedures have been registered in databases for a wide variety of diseases, predominantly for treatment with autologous HSCT...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316389/cell-therapy
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316388/compound-heterozygous-slc29a3-mutation-causes-h-syndrome-in-a-moroccan-patient-a-case-report
#17
A Bakhchane, Z Kindil, H Charoute, K Benchikhi, K Khadir, S Nadifi, K Baline, R Roky, A Barakat
H syndrome is an autosomal recessive syndrome, which affects the skin and some vital organs, it is caused by mutations in the SLC29A3 gene, encoding the human equilibrative nucleoside transporter hENT3. This report describes a patient with typical features of H syndrome. Based on the patient's clinical features, SLC29A3 was selected for molecular investigation. Through direct sequencing, a compound heterozygous alteration in the SLC29A3 gene was found. The c.243delA frameshift mutation leading to a premature termination, resulting in a truncated protein, and a splice site mutation c...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316387/intra-familial-phenotypic-variability-in-a-moroccan-family-with-hearing-loss-and-palmoplantar-keratoderma-ppk
#18
A Bousfiha, A Bakhchane, S Elrharchi, H Dehbi, M Kabine, S Nadifi, H Charoute, A Barakat
Mutations in the GJB2 gene encoding connexin 26 are the main cause of hereditary hearing impairment. These mutations generate mainly autosomal recessive and rarely autosomal dominant deafness. Dominant mutations in GJB2 can be responsible for isolated deafness as well as syndromic hearing loss associated with various skin abnormalities. Until now few papers discuss dominant mutations in the GJB2 gene. In this work we report a rare case about a Moroccan family with a compound heterozygous mutation (the dominant p...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316386/no-significant-effects-of-poly-i-c-on-human-umbilical-cord-derived-mesenchymal-stem-cells-in-the-treatment-of-b6-mrl-fas-lpr-mice
#19
S Huang, D Wang, F Gu, Z Zhang, W Deng, W Chen, X Tang, G Yao, X Feng, L Sun
OBJECTIVE: Our study aimed to compare the curative effect and immunoregulation between MSCs activated by Poly(I:C) for 24hours and unactivated MSCs on lupus mice. MATERIALS AND METHODS: MSCs were pretreated by Poly(I:C) at 50μg/mL for 24h. B6.MRL-Fas(lpr) mice were divided into UC-MSC treated group, FLS treated group, Poly(I:C) preconditioned MSC treated group (P-MSC) and untreated group randomly. All treated mice were infused with 1×10(6) MSCs or FLSs at the 24th week and were sacrificed 4 weeks later...
April 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27316385/zika-virus-epidemics-in-brazil-a-broad-view
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Current Research in Translational Medicine
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