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International Journal of Reproductive Biomedicine (Yazd, Iran)

Ensieh Shahrokh Tehrani Nejad, Fatemeh Bakhtiari Ghaleh, Bita Eslami, Fedyeh Haghollahi, Maryam Bagheri, Masoumeh Masoumi
Background: Both oral contraceptive pills (OCPs) and estradiol valerate (E2) have been used to schedule a gonadotropin-releasing hormone antagonist in vitro fertilization (IVF) cycles. Since the suppression of follicle-stimulating hormone by OCPs can stay 5-7 days after stopping the pills, it seems that starting the gonadotropin-releasing hormone (GnRH) after 6 days of pre-treatment discontinuation may be important in IVF outcomes. Objective: The aim of the present study was to determine the number of mature oocyte and pregnancy rate of three pretreatment methods for fresh embryo transfer cycles...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Rehana Rehman, Mohsin Mehmood, Rabiya Ali, Saeeda Shaharyar, Faiza Alam
Background: Obesity may establish a crucial barrier for effective fertility treatment in polycystic ovary syndrome (PCOS) females. Objective: To compare results of intra-cytoplasmic sperm injection (ICSI) in females with and without polycystic ovarian syndrome and further appraise the effect of obesity in PCOS females. Materials and Methods: A cross-sectional study from June 2015 to July 2016 included non-PCOS and PCOS (recognized by Rotterdam criteria) females who underwent ICSI...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Masoumeh Fani, Abbas Mohammadipour, Alireza Ebrahimzadeh-Bideskan
Background: Atrazine as a herbicide may affect the human's health. Crocin may protect atrazine-induced damages. Objective: The aim of this study was to evaluate the effects of atrazine on mice testicular tissue and sperm parameters and protective effects of Crocin on probably atrazine-induced damages. Materials and Methods: in this experimental study, 24 pregnant Balb/c mice were randomly divided to 4 groups: I: Atrazine (10 mg/kg), II: Atrazine-Crocin, III: Crocin (10mg/kg) and IV: Normal saline...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Maryam Gholamitabar Tabari, Seyed Gholam Ali Jorsaraei, Mohammad Ghasemzadeh-Hasankolaei, Ali Asghar Ahmadi, Neda Mahdinezhad Gorji
Background: Bone morphogenetic protein 4 (BMP4) is a significant signaling molecule that involves in initiating of differentiation and performs multifunctional effects on embryonic stem cells (ESCs) and embryos. Objective: The goal of the present study was to evaluate an in vitro differentiation model of mouse embryonic stem cells into germ cells, using BMP4. Materials and Methods: in this experimental study, we used Oct4-GFP mouse ESCs to form embryoid body (EB) aggregations for two days...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Seyed Hamidreza Mirabutalebi, Noorodin Karami, Fatemeh Montazeri, Farzaneh Fesahat, Mohammad Hasan Sheikhha, Elnaz Hajimaqsoodi, Mojgan Karimi Zarchi, Seyed Mehdi Kalantar
Background: The study of microRNA expression can be effective in the diagnosing and treating different diseases. miR-135a is one of the most important micro-ribonucleic acids involved in endometriosis. Among the genes that become the target of the miR-135a and are subjected to changes in the endometrium of patients with endometriosis is HOXA10 gene which is expressed in the endometrium in response to steroid hormones. Objective: The aim of this study was to evaluate the expression of miR-135a and its relationship with the level of HOXA10 gene expression in both endometrial ectopic and eutopic tissues in patients with endometriosis compared to the control samples...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Pedro Gonzalez-Añover, Laura Torres-Rovira, Consolacion García-Contreras, Marta Vazquez-Gomez, Jose Luis Pesantez, Maria Victoria Sanz-Fernandez, Susana Astiz, Antonio Gonzalez-Bulnes
Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction. Objective: We aimed to investigate the underlying mechanisms of the leptin-resistance, evaluating the antioxidant homeostasis of leptin-resistant and lean swine fetuses. Materials and Methods: The study included 70 plasma samples from fetuses at day 62 of gestation (mid-pregnancy), from breeds with (Iberian breed; n=35) and without leptin resistance (25% Large White x 25% Landrace x 50% Pietrain; n=35)...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Zeinab Ebrahim Abadi, Maryam Khademi Bami, Maryam Golzadeh, Seyed Mehdi Kalantar, Mohammad Hasan Sheikhha
Background: Tumor protein p53 ( TP53 ) is a tumor suppressor transcriptional regulator protein which plays a critical role in the spermatogenesis. One of the most important regulators of p53 is Murine double minute 2 ( MDM2 ), which acts as a negative regulator of the p53 pathway. Based on the key role of p53 and MDM2 in germ cell apoptosis, polymorphisms that cause a change in their function might affect germ cell apoptosis and the risk of male infertility. Objective: This study was designed to examine associations of TP53 72 Arg>Pro (rs1042522), and MDM2 309 T>G (rs937283) polymorphisms with spermatogenetic failure in Iranian population...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Nasim Tabibnejad, Mehrdad Soleimani, Abbas Aflatoonian
Background: Anti-Mullerian hormone (AMH) is considered as a good marker for quantitative evaluation of ovarian response to the stimulation during assisted reproductive technology cycles. Objective: To evaluate the association between serum AMH level and embryo morphokinetics using time-lapse imaging and intracytoplasmic sperm injection (ICSI) outcomes in women with polycystic ovarian syndrome (PCOS). Materials and Methods: We evaluated a total of 547 embryos from 100 women underwent ICSI cycles; 50 women with PCOS and 50 women with tubal factor infertility...
August 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Aylin Esmailkhani, Mohammad Taghi Akhi, Javid Sadeghi, Behrooz Niknafs, Abed Zahedi Bialvaei, Laya Farzadi, Nooshafarin Safadel
Background: Staphylococcus aureus is an infrequent, but one of the most successful bacteria that associated with infertility and are able to spermatozoa immobilization and agglutination. Objective: The aim of present study was to determine the frequency of S. aureus in semen obtained from infertile male patients in northwest Iran. Materials and Methods: Seminal fluids of 100 infertile men were evaluated. Standard semen examination was done according to World Health Organization guidelines...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Mahnaz Heidari, Niknam Lakpour, Mahsa Darbandi, Sara Darbani, Saeideh Shani, Leila Goharbakhsh, Ghazaleh Cheshmi, Mohammad Mehdi Akhondi, Mohammad Reza Sadeghi
Background: Sperm processing methods separate motile sperms with good morphology from dead and abnormal forms of sperms, immature germ cells, and non-sperm cells. Objective: The propose of this study was to compare the efficacy of upstream and swim-up processing techniques to separate sperms with the high quality especially in relation to sperm chromatin integrity. Materials and Methods: This experimental study used semen samples from 60 normozoospermic men...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Faduola Paul, Gbolahan Oladele Obajimi, Charles Olubukunmi Kolade
Background: Sperm morphology has been strongly linked to fertilization. This makes it an important component in semen analysis. They are usually assessed by world health organization (WHO) standard or Kruger strict criteria in in-vitro fertilization (IVF) centers all over the world. Sperm count, motility, and morphology together form the basis by which patients are allocated into IVF or intra-cytoplasmic sperm injection. Objective: This study aimed to compare fertilization rates in standard IVF from patients with normal sperm count and motility with and without morphological assessment by WHO guideline...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Soheila Gholizadeh, Shahideh Jahanian Sadatmahalleh, Saeideh Ziaei
Background: Levels of estradiol decreases as women arrive the menopausal transition and enter to a low, steady level during the early postmenopause. In addition, memory dysfunction are highly prevalent during this period. Objective: Our study was designed to determine whether endogenous levels of estradiol are related to cognitive function in postmenopausal. Materials and Methods: The cross-sectional study was conducted between November 2015 to February 2016 on 209 healthy postmenopausal women...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Naser Khalaji, Mahshid Namyari, Yousef Rasmi, Masoumeh Pourjabali, Leila Chodari
Background: Testicular function is modified by maturational gonadostatic control highly susceptible to negative physiologic niche-altering factors like UV-rays. Objective: This study was performed in order to uncover new aspects of Compact Florescent Lamps (CFLs) induced damages on the testicular tissue of rats and evaluating the effect of curcumin on testis of rats after exposure to compact florescent Lamps. Materials and Methods: Twenty-four adult male Albino rats were randomly divided into three groups: control group (ethyl oleate 0...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Majid Mohseni, Hamid Reza Mollaei, Seyed Alimohammad Arabzadeh, Tooraj Reza Mirshekari, Peyman Ghorbani
Background: Cytomegalovirus (CMV) virus can hide in urinary genital tract cells and affect male infertility disorders. Objective: To evaluate frequency of CMV in the semen samples of men with infertility problems referring to a in vitro fertilization (IVF) center in Kerman, Iran and its association with the parameters of semen. Materials and Methods: In this case-control study, Real time polymerase chain reaction test was performed for detection of human cytomegalovirus in 100 fertile men compared to 100 infertile men referred to the IVF center of Afzalipour Hospital, Kerman, Iran...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Mathias Abiodun Emokpae, Happy Ngozi Chima
Background: Male senescence may affect testicular function, sperm indices and generation of high levels of oxidants and apoptosis. Objective: This study evaluates the effect of male age on the expression of some apoptosis and oxidative stress markers in seminal fluid of males investigated for infertility in a tertiary health institution in Nigeria. Materials and Methods: In this cross-sectional study, 122 men aged 20-60 yr who were investigated for infertility and were stratified according to age into four groups...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Hassan Boskabadi, Maryam Zakerihamidi, Raheleh Faramarzi
Background: Intra-ventricular hemorrhage (IVH) is acute cerebral complications of premature infants which may lead to the long-term problems. Objective: According to the role of vitamin D in the stability of the blood vessels, the present study was carried out in order to compare the vitamin D level in the premature infants with or without IVH. Materials and Methods: This cross-sectional study was carried out on 180 premature infants in the Ghaem Hospital, Mashhad, Iran 97 infants without IVH (53...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Zohreh Yousefi, Hekmat Khalilifar, Amir Hosein Jafarian, Behrouz Davachi, Leila Mousavi Seresh, Nooshin Babapour, Laya Shirinzadeh, Mina Baradaran
Background: Ovarian superovulation and increased follicle-stimulating hormone concentration for infertility treatment may be the risk factors of developed granulosa-cell tumor. The aim of this report is to introduce a case of granulosa-cell tumor which was discovered after ovarian stimulation. Case: A 31-yr-old woman with clinical presentation of massive abdominal distention was referred to the gynecology and oncology department of an academic hospital, Mashhad University of Medical Sciences in Aug 2017...
June 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Sepideh Khodaverdi, Soheila Amini-Moghaddam, Fariba Almassi Nokiani, Neda Hashemi, Robabeh Mohammad Beigi
Background: It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma. Case: In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact endometrioma and extensive involvement of omentum. Conclusion: Human Epididymis protein (HE4) and Risk of ovarian malignancy algorithm (ROMA) can be useful in differentiation between malignancies and benign pathologies with a good sensitivity and specificity value...
June 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Mona Ghasemi, Abbas Farshad, Hadi Hajarian, Omid Banafshi, Vahideh Asadollahi, Fardin Fathi
Background: Sericin, because of its ability to remove free radicals and its antioxidant properties, has been used to successfully cryopreserve various mammalian cell types. However, the effects of sericin on cryopreservation of mouse sperm has not been reported. Objective: The current study intended to determine the protective role of different concentrations of sericin (0, 0.25, 0.5, and 0.75%) on mouse spermatozoa during cryopreservation, in addition to its effect on in vitro fertilization and subsequent embryo development...
June 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Mojtaba Karimipour, Masoumeh Zirak Javanmard, Abbas Ahmadi, Abbas Jafari
Background: Titanium dioxide nanoparticle (TiO2 NP) is commonly used in industrial products including food colorant, cosmetics, and drugs. Previous studies have shown that oral administration of TiO2 NP can be toxic to the reproductive system, but little is known if TiO2 NP could be able to affect the functions of the female reproductive system, in particular fertility. Objective: The objective was to evaluate the effects of oral administration of TiO2 NP on histological changes in ovaries, pregnancy rate and in vitro fertility in mice...
June 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
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