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Nature Reviews. Disease Primers

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https://www.readbyqxmd.com/read/28905944/snakebite-envenoming
#1
REVIEW
José María Gutiérrez, Juan J Calvete, Abdulrazaq G Habib, Robert A Harrison, David J Williams, David A Warrell
Snakebite envenoming is a neglected tropical disease that kills >100,000 people and maims >400,000 people every year. Impoverished populations living in the rural tropics are particularly vulnerable; snakebite envenoming perpetuates the cycle of poverty. Snake venoms are complex mixtures of proteins that exert a wide range of toxic actions. The high variability in snake venom composition is responsible for the various clinical manifestations in envenomings, ranging from local tissue damage to potentially life-threatening systemic effects...
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28905943/snakebite-envenoming
#2
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28905942/authors-reply-predictive-diagnostic-tests-in-periodontal-diseases
#3
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28905941/a-quantitative-point-of-care-test-for-periodontal-and-dental-peri-implant-diseases
#4
Timo Sorsa, Dirk Gieselmann, Nicole B Arweiler, Marcela Hernández
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28880010/chronic-pancreatitis
#5
REVIEW
Jorg Kleeff, David C Whitcomb, Tooru Shimosegawa, Irene Esposito, Markus M Lerch, Thomas Gress, Julia Mayerle, Asbjørn Mohr Drewes, Vinciane Rebours, Fatih Akisik, J Enrique Domínguez Muñoz, John P Neoptolemos
Chronic pancreatitis is defined as a pathological fibro-inflammatory syndrome of the pancreas in individuals with genetic, environmental and/or other risk factors who develop persistent pathological responses to parenchymal injury or stress. Potential causes can include toxic factors (such as alcohol or smoking), metabolic abnormalities, idiopathic mechanisms, genetics, autoimmune responses and obstructive mechanisms. The pathophysiology of chronic pancreatitis is fairly complex and includes acinar cell injury, acinar stress responses, duct dysfunction, persistent or altered inflammation, and/or neuro-immune crosstalk, but these mechanisms are not completely understood...
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28880009/chronic-pancreatitis
#6
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 7, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28857067/hypoparathyroidism
#7
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28857066/hypoparathyroidism
#8
REVIEW
Michael Mannstadt, John P Bilezikian, Rajesh V Thakker, Fadil M Hannan, Bart L Clarke, Lars Reijnmark, Deborah M Mitchell, Tamara J Vokes, Karen K Winer, Dolores M Shoback
Hypoparathyroidism is a disease characterized by inadequately low circulating concentrations of parathyroid hormone (PTH) resulting in low calcium levels and increased phosphate levels in the blood. Symptoms of the disease result from increased neuromuscular irritability caused by hypocalcaemia and include tingling, muscle cramps and seizures. The most common cause of the disease is inadvertent removal of, or injury to, the parathyroid glands during neck surgery, followed by genetic, idiopathic and autoimmune aetiologies...
August 31, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28836626/heart-failure-with-reduced-ejection-fraction
#9
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 24, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28836616/heart-failure-with-reduced-ejection-fraction
#10
REVIEW
Michelle W Bloom, Barry Greenberg, Tiny Jaarsma, James L Januzzi, Carolyn S P Lam, Aldo P Maggioni, Jean-Noël Trochu, Javed Butler
Heart failure is a global public health problem that affects more than 26 million people worldwide. The global burden of heart failure is growing and is expected to increase substantially with the ageing of the population. Heart failure with reduced ejection fraction accounts for approximately 50% of all cases of heart failure in the United States and is associated with substantial morbidity and reduced quality of life. Several diseases, such as myocardial infarction, certain infectious diseases and endocrine disorders, can initiate a primary pathophysiological process that can lead to reduced ventricular function and to heart failure...
August 24, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28820189/osteogenesis-imperfecta
#11
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28820180/osteogenesis-imperfecta
#12
REVIEW
Joan C Marini, Antonella Forlino, Hans Peter Bächinger, Nick J Bishop, Peter H Byers, Anne De Paepe, Francois Fassier, Nadja Fratzl-Zelman, Kenneth M Kozloff, Deborah Krakow, Kathleen Montpetit, Oliver Semler
Skeletal deformity and bone fragility are the hallmarks of the brittle bone dysplasia osteogenesis imperfecta. The diagnosis of osteogenesis imperfecta usually depends on family history and clinical presentation characterized by a fracture (or fractures) during the prenatal period, at birth or in early childhood; genetic tests can confirm diagnosis. Osteogenesis imperfecta is caused by dominant autosomal mutations in the type I collagen coding genes (COL1A1 and COL1A2) in about 85% of individuals, affecting collagen quantity or structure...
August 18, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28770818/correction-lyme-borreliosis
#13
Allen C Steere, Strle Franc, Gary P Wormser, Linden T Hu, John A Branda, Joppe W R Hovius, Xin Li, Paul S Mead
This corrects the article DOI: 10.1038/nrdp.2016.90.
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28770817/malaria
#14
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28770814/malaria
#15
REVIEW
Margaret A Phillips, Jeremy N Burrows, Christine Manyando, Rob Hooft van Huijsduijnen, Wesley C Van Voorhis, Timothy N C Wells
Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes. Malaria remains one of the most serious infectious diseases; it threatens nearly half of the world's population and led to hundreds of thousands of deaths in 2015, predominantly among children in Africa. Malaria is managed through a combination of vector control approaches (such as insecticide spraying and the use of insecticide-treated bed nets) and drugs for both treatment and prevention...
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28748920/oesophageal-cancer
#16
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28748917/oesophageal-cancer
#17
REVIEW
Elizabeth C Smyth, Jesper Lagergren, Rebecca C Fitzgerald, Florian Lordick, Manish A Shah, Pernilla Lagergren, David Cunningham
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and is therefore a major global health challenge. The two major subtypes of oesophageal cancer are oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC), which are epidemiologically and biologically distinct. OSCC accounts for 90% of all cases of oesophageal cancer globally and is highly prevalent in the East, East Africa and South America. OAC is more common in developed countries than in developing countries...
July 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726797/multiple-myeloma
#18
REVIEW
Shaji K Kumar, Vincent Rajkumar, Robert A Kyle, Mark van Duin, Pieter Sonneveld, María-Victoria Mateos, Francesca Gay, Kenneth C Anderson
Multiple myeloma is a malignancy of terminally differentiated plasma cells, and patients typically present with bone marrow infiltration of clonal plasma cells and monoclonal protein in the serum and/or urine. The diagnosis of multiple myeloma is made when clear end-organ damage attributable to the plasma cell proliferative disorder or when findings that suggest a high likelihood of their development are present. Distinguishing symptomatic multiple myeloma that requires treatment from the precursor stages of monoclonal gammopathy of undetermined significance and smouldering multiple myeloma is important, as observation is the standard for those conditions...
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726793/correction-vitamin-b12-deficiency
#19
Ralph Green, Lindsay H Allen, Anne-Lise Bjørke-Monsen, Alex Brito, Jean-Louis Guéant, Joshua W Miller, Anne M Molloy, Ebba Nexo, Sally Stabler, Ban-Hock Toh, Per Magne Ueland, Chittaranjan Yajnik
This corrects the article DOI: 10.1038/nrdp.2017.40.
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726792/multiple-myeloma
#20
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Disease Primers
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