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Nature Reviews. Disease Primers

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https://www.readbyqxmd.com/read/28770818/correction-lyme-borreliosis
#1
Allen C Steere, Strle Franc, Gary P Wormser, Linden T Hu, John A Branda, Joppe W R Hovius, Xin Li, Paul S Mead
This corrects the article DOI: 10.1038/nrdp.2016.90.
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28770817/malaria
#2
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28770814/malaria
#3
REVIEW
Margaret A Phillips, Jeremy N Burrows, Christine Manyando, Rob Hooft van Huijsduijnen, Wesley C Van Voorhis, Timothy N C Wells
Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes. Malaria remains one of the most serious infectious diseases; it threatens nearly half of the world's population and led to hundreds of thousands of deaths in 2015, predominantly among children in Africa. Malaria is managed through a combination of vector control approaches (such as insecticide spraying and the use of insecticide-treated bed nets) and drugs for both treatment and prevention...
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28748920/oesophageal-cancer
#4
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28748917/oesophageal-cancer
#5
REVIEW
Elizabeth C Smyth, Jesper Lagergren, Rebecca C Fitzgerald, Florian Lordick, Manish A Shah, Pernilla Lagergren, David Cunningham
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide and is therefore a major global health challenge. The two major subtypes of oesophageal cancer are oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC), which are epidemiologically and biologically distinct. OSCC accounts for 90% of all cases of oesophageal cancer globally and is highly prevalent in the East, East Africa and South America. OAC is more common in developed countries than in developing countries...
July 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726797/multiple-myeloma
#6
REVIEW
Shaji K Kumar, Vincent Rajkumar, Robert A Kyle, Mark van Duin, Pieter Sonneveld, María-Victoria Mateos, Francesca Gay, Kenneth C Anderson
Multiple myeloma is a malignancy of terminally differentiated plasma cells, and patients typically present with bone marrow infiltration of clonal plasma cells and monoclonal protein in the serum and/or urine. The diagnosis of multiple myeloma is made when clear end-organ damage attributable to the plasma cell proliferative disorder or when findings that suggest a high likelihood of their development are present. Distinguishing symptomatic multiple myeloma that requires treatment from the precursor stages of monoclonal gammopathy of undetermined significance and smouldering multiple myeloma is important, as observation is the standard for those conditions...
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726793/correction-vitamin-b12-deficiency
#7
Ralph Green, Lindsay H Allen, Anne-Lise Bjørke-Monsen, Alex Brito, Jean-Louis Guéant, Joshua W Miller, Anne M Molloy, Ebba Nexo, Sally Stabler, Ban-Hock Toh, Per Magne Ueland, Chittaranjan Yajnik
This corrects the article DOI: 10.1038/nrdp.2017.40.
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28726792/multiple-myeloma
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28703220/tumour-induced-osteomalacia
#9
REVIEW
Salvatore Minisola, Munro Peacock, Seijii Fukumoto, Cristiana Cipriani, Jessica Pepe, Sri Harsha Tella, Michael T Collins
Tumour-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare paraneoplastic disorder caused by tumours that secrete fibroblast growth factor 23 (FGF23). Owing to the role of FGF23 in renal phosphate handling and vitamin D synthesis, TIO is characterized by decreased renal tubular reabsorption of phosphate, by hypophosphataemia and by low levels of active vitamin D. Chronic hypophosphataemia ultimately results in osteomalacia (that is, inadequate bone mineralization). The diagnosis of TIO is usually suspected when serum phosphate levels are chronically low in the setting of bone pain, fragility fractures and muscle weakness...
July 13, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28703216/tumour-induced-osteomalacia
#10
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 13, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28681849/urinary-incontinence-in-women
#11
REVIEW
Yoshitaka Aoki, Heidi W Brown, Linda Brubaker, Jean Nicolas Cornu, J Oliver Daly, Rufus Cartwright
Urinary incontinence symptoms are highly prevalent among women, have a substantial effect on health-related quality of life and are associated with considerable personal and societal expenditure. Two main types are described: stress urinary incontinence, in which urine leaks in association with physical exertion, and urgency urinary incontinence, in which urine leaks in association with a sudden compelling desire to void. Women who experience both symptoms are considered as having mixed urinary incontinence...
July 6, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28681847/urinary-incontinence-in-women
#12
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
July 6, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28660905/vitamin-b12-deficiency
#13
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28660890/vitamin-b12-deficiency
#14
REVIEW
Ralph Green, Lindsay H Allen, Anne-Lise Bjørke-Monsen, Alex Brito, Jean-Louis Guéant, Joshua W Miller, Anne M Molloy, Ebba Nexo, Sally Stabler, Ban-Hock Toh, Per Magne Ueland, Chittaranjan Yajnik
Vitamin B12 (B12; also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. Clinical B12 deficiency with classic haematological and neurological manifestations is relatively uncommon. However, subclinical deficiency affects between 2.5% and 26% of the general population depending on the definition used, although the clinical relevance is unclear. B12 deficiency can affect individuals at all ages, but most particularly elderly individuals...
June 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28805207/periodontal-diseases
#15
REVIEW
Denis F Kinane, Panagiota G Stathopoulou, Panos N Papapanou
Periodontal diseases comprise a wide range of inflammatory conditions that affect the supporting structures of the teeth (the gingiva, bone and periodontal ligament), which could lead to tooth loss and contribute to systemic inflammation. Chronic periodontitis predominantly affects adults, but aggressive periodontitis may occasionally occur in children. Periodontal disease initiation and propagation is through a dysbiosis of the commensal oral microbiota (dental plaque), which then interacts with the immune defences of the host, leading to inflammation and disease...
June 22, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28638153/periodontal-diseases
#16
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 22, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28617414/obesity
#17
REVIEW
Pedro González-Muniesa, Miguel-Angel Mártinez-González, Frank B Hu, Jean-Pierre Després, Yuji Matsuzawa, Ruth J F Loos, Luis A Moreno, George A Bray, J Alfredo Martinez
Excessive fat deposition in obesity has a multifactorial aetiology, but is widely considered the result of disequilibrium between energy intake and expenditure. Despite specific public health policies and individual treatment efforts to combat the obesity epidemic, >2 billion people worldwide are overweight or obese. The central nervous system circuitry, fuel turnover and metabolism as well as adipose tissue homeostasis are important to comprehend excessive weight gain and associated comorbidities. Obesity has a profound impact on quality of life, even in seemingly healthy individuals...
June 15, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28617413/obesity
#18
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28593997/severe-congenital-neutropenias
#19
REVIEW
Julia Skokowa, David C Dale, Ivo P Touw, Cornelia Zeidler, Karl Welte
Severe congenital neutropenias are a heterogeneous group of rare haematological diseases characterized by impaired maturation of neutrophil granulocytes. Patients with severe congenital neutropenia are prone to recurrent, often life-threatening infections beginning in their first months of life. The most frequent pathogenic defects are autosomal dominant mutations in ELANE, which encodes neutrophil elastase, and autosomal recessive mutations in HAX1, whose product contributes to the activation of the granulocyte colony-stimulating factor (G-CSF) signalling pathway...
June 8, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28593943/severe-congenital-neutropenias
#20
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2017: Nature Reviews. Disease Primers
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