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Nature Reviews. Disease Primers

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https://www.readbyqxmd.com/read/29143807/urinary-incontinence-in-women
#1
Yoshitaka Aoki, Heidi W Brown, Linda Brubaker, Jean Nicolas Cornu, J Oliver Daly, Rufus Cartwright
This corrects the article DOI: 10.1038/nrdp.2017.42.
November 16, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29143806/hepatitis-e-virus-infection
#2
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
November 16, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29119972/rotavirus-infection
#3
REVIEW
Sue E Crawford, Sasirekha Ramani, Jacqueline E Tate, Umesh D Parashar, Lennart Svensson, Marie Hagbom, Manuel A Franco, Harry B Greenberg, Miguel O'Ryan, Gagandeep Kang, Ulrich Desselberger, Mary K Estes
Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system...
November 9, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29119965/rotavirus-infection
#4
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
November 9, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29099094/functional-dyspepsia
#5
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
November 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29099093/functional-dyspepsia
#6
REVIEW
Paul Enck, Fernando Azpiroz, Guy Boeckxstaens, Sigrid Elsenbruch, Christine Feinle-Bisset, Gerald Holtmann, Jeffrey M Lackner, Jukka Ronkainen, Michael Schemann, Andreas Stengel, Jan Tack, Stephan Zipfel, Nicholas J Talley
Functional dyspepsia is one of the most prevalent functional gastrointestinal disorders. Functional dyspepsia comprises three subtypes with presumed different pathophysiology and aetiology: postprandial distress syndrome (PDS), epigastric pain syndrome (EPS) and a subtype with overlapping PDS and EPS features. Functional dyspepsia symptoms can be caused by disturbed gastric motility (for example, inadequate fundic accommodation or delayed gastric emptying), gastric sensation (for example, sensations associated with hypersensitivity to gas and bloating) or gastric and duodenal inflammation...
November 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29072302/merkel-cell-carcinoma
#7
REVIEW
Jürgen C Becker, Andreas Stang, James A DeCaprio, Lorenzo Cerroni, Celeste Lebbé, Michael Veness, Paul Nghiem
Merkel cell carcinoma (MCC) is a rare but highly aggressive skin cancer with neuroendocrine features. MCC pathogenesis is associated with either the presence of Merkel cell polyomavirus or chronic exposure to ultraviolet light (UV), which can cause a characteristic pattern of multiple DNA mutations. Notably, in the Northern hemisphere, the majority of MCC cases are of viral aetiology; by contrast, in areas with high UV exposure, UV-mediated carcinogenesis is predominant. The two aetiologies share similar clinical, histopathological and prognostic characteristics...
October 26, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29072252/merkel-cell-carcinoma
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 26, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29052611/amyotrophic-lateral-sclerosis
#9
Orla Hardiman, Ammar Al-Chalabi, Adriano Chio, Emma M Corr, Giancarlo Logroscino, Wim Robberecht, Pamela J Shaw, Zachary Simmons, Leonard H van den Berg
This corrects the article DOI: 10.1038/nrdp.2017.71.
October 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29052583/idiopathic-pulmonary-fibrosis
#10
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29052582/idiopathic-pulmonary-fibrosis
#11
REVIEW
Fernando J Martinez, Harold R Collard, Annie Pardo, Ganesh Raghu, Luca Richeldi, Moises Selman, Jeffrey J Swigris, Hiroyuki Taniguchi, Athol U Wells
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease characterized by progressive lung scarring and the histological picture of usual interstitial pneumonia (UIP). It is associated with increasing cough and dyspnoea and impaired quality of life. IPF affects ∼3 million people worldwide, with incidence increasing dramatically with age. The diagnostic approach includes the exclusion of other interstitial lung diseases or overlapping conditions and depends on the identification of the UIP pattern, usually with high-resolution CT; lung biopsy might be required in some patients...
October 20, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29022573/syphilis
#12
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29022569/syphilis
#13
REVIEW
Rosanna W Peeling, David Mabey, Mary L Kamb, Xiang-Sheng Chen, Justin D Radolf, Adele S Benzaken
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries...
October 12, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28980624/amyotrophic-lateral-sclerosis
#14
REVIEW
Orla Hardiman, Ammar Al-Chalabi, Adriano Chio, Emma M Corr, Giancarlo Logroscino, Wim Robberecht, Pamela J Shaw, Zachary Simmons, Leonard H van den Berg
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the involvement of the non-motor neuraxis in disease pathology. In most patients, the mechanisms underlying the development of ALS are poorly understood, although a subset of patients have familial disease and harbour mutations in genes that have various roles in neuronal function...
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28980623/amyotrophic-lateral-sclerosis
#15
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28980622/snakebite-envenoming
#16
José María Gutiérrez, Juan J Calvete, Abdulrazaq G Habib, Robert A Harrison, David J Williams, David A Warrell
This corrects the article DOI: 10.1038/nrdp.2017.63.
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28980621/hypoparathyroidism
#17
Michael Mannstadt, John P Bilezikian, Rajesh V Thakker, Fadil M Hannan, Bart L Clarke, Rejnmark Lars, Deborah M Mitchell, Tamara J Vokes, Karen K Winer, Dolores M Shoback
This corrects the article DOI: 10.1038/nrdp.2017.55.
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28960190/fragile-x-syndrome
#18
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28960184/fragile-x-syndrome
#19
REVIEW
Randi J Hagerman, Elizabeth Berry-Kravis, Heather Cody Hazlett, Donald B Bailey, Herve Moine, R Frank Kooy, Flora Tassone, Ilse Gantois, Nahum Sonenberg, Jean Louis Mandel, Paul J Hagerman
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism spectrum disorder, and patients can present with severe behavioural alterations, including hyperactivity, impulsivity and anxiety, in addition to poor language development and seizures. FXS is a trinucleotide repeat disorder, in which >200 repeats of the CGG motif in FMR1 leads to silencing of the gene and the consequent loss of its product, fragile X mental retardation 1 protein (FMRP). FMRP has a central role in gene expression and regulates the translation of potentially hundreds of mRNAs, many of which are involved in the development and maintenance of neuronal synaptic connections...
September 29, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28933422/severe-childhood-malnutrition
#20
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
September 21, 2017: Nature Reviews. Disease Primers
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