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Advances in Radiation Oncology

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https://www.readbyqxmd.com/read/29556586/the-civasheet-the-new-frontier-of-intraoperative-radiation-therapy-or-a-pricier-alternative-to-ldr-brachytherapy
#1
Danushka Seneviratne, Christopher McLaughlin, Dorin Todor, Brian Kaplan, Emma C Fields
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556585/brachial-plexopathy-after-stereotactic-body-radiation-therapy-for-apical-lung-cancer-dosimetric-analysis-and-preliminary-clinical-outcomes
#2
Sumit S Sood, Christopher McClinton, Rajeev Badkul, Nathan Aguilera, Fen Wang, Allen M Chen
Purpose: The treatment of apical lung tumors with stereotactic body radiation therapy (SBRT) is challenging due to the proximity of the brachial plexus and the concern for nerve damage. Methods and materials: Between June 2009 and February 2017, a total of 75 consecutive patients underwent SBRT for T1-T3N0 non-small cell lung cancer involving the upper lobe of the lung. All patients were treated with 4-dimensional computed tomography (CT)-based image guided SBRT to a dose of 40 to 60 Gy in 3 to 5 fractions...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556584/congenital-ichthyosis-patient-with-squamous-cell-carcinoma-of-the-skin-who-received-concurrent-chemoradiation-a-case-report
#3
Alberto Cerra-Franco, Sara J Grethlein, Todd E Bertrand, William A Wooden, Naoyuki G Saito
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556583/estimating-changes-in-the-rate-of-synchronous-and-metachronous-metastases-over-time-analysis-of-seer-data
#4
Ugur Yilmaz, Lawrence B Marks
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556582/premature-discontinuation-of-curative-radiation-therapy-insights-from-head-and-neck-irradiation
#5
Stanislav Lazarev, Vishal Gupta, Zahra Ghiassi-Nejad, Brett Miles, Bethann Scarborough, Krzysztof J Misiukiewicz, Batya Reckson, Ren-Dih Sheu, Richard L Bakst
Purpose: Factors related to premature discontinuation of curative radiation therapy (PDCRT) are understudied. This study aimed to examine causes and clinical outcomes of PDCRT at our institution by investigating the most common anatomical site associated with PDCRT. Methods and materials: Among the 161 patients with PDCRT of various anatomic sites at our institution between 2010 and 2017, 36% received radiation to the head and neck region. Pertinent demographic, clinical, and treatment-related data on these 58 patients were collected...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556581/stereotactic-body-radiation-therapy-for-medically-inoperable-clinically-localized-urothelial-carcinoma-of-the-renal-pelvis-a-case-report
#6
Jaden D Evans, Chase C Hansen, Matthew K Tollefson, Christopher L Hallemeier
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556580/salvage-image-guided-radiation-therapy-to-the-prostate-after-cryotherapy-failure
#7
Austin B Hopper, Ajay P S Sandhu, J Kellogg Parsons, Brent Rose, John P Einck
Purpose: Cryotherapy is an option for the primary treatment of localized prostate cancer, along with radical prostatectomy, external beam radiation therapy, and brachytherapy. Although it is known that local recurrence can occur in >20% of patients treated with primary cryotherapy, unfortunately there is a paucity of data on later salvage treatments. The use of external beam radiation therapy is an attractive option after cryotherapy failure, but there is little data on its efficacy and toxicity...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556579/long-term-analysis-of-2-prospective-studies-that-incorporate-mitomycin-c-into-an-adjuvant-chemoradiation-regimen-for-pancreatic-and-periampullary-cancers
#8
Kathryn J Schunke, Lauren M Rosati, Marianna Zahurak, Joseph M Herman, Amol K Narang, Irina Usach, Alison P Klein, Charles J Yeo, Larry T Korman, Ralph H Hruban, John L Cameron, Daniel A Laheru, Ross A Abrams
Purpose: The purpose of this study was to report toxicity and long-term survival outcomes of 2 prospective trials evaluating mitomycin C (MMC) with 5-fluorouracil-based adjuvant chemoradiation in resected periampullary adenocarcinoma. Methods and materials: From 1996 to 2002, 119 patients received an adjuvant 4-drug chemotherapy regimen of 5-fluorouracil, leucovorin, MMC, and dipyridamole with chemoradiation on 2 consecutive trials (trials A and B). Trial A patients received upfront chemoradiation (50 Gy split-course, 2...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556578/trends-in-intensity-modulated-radiation-therapy-use-for-locally-advanced-rectal-cancer-at-national-comprehensive-cancer-network-centers
#9
Marsha Reyngold, Joyce Niland, Anna Ter Veer, Tanios Bekaii-Saab, Lily Lai, Joshua E Meyer, Steven J Nurkin, Deborah Schrag, John M Skibber, Al B Benson, Martin R Weiser, Christopher H Crane, Karyn A Goodman
Purpose: Intensity modulated radiation therapy (IMRT) has been rapidly incorporated into clinical practice because of its technological advantages over 3-dimensional conformal radiation therapy (CRT). We characterized trends in IMRT utilization in trimodality treatment of locally advanced rectal cancer at National Comprehensive Cancer Network cancer centers between 2005 and 2011. Methods and materials: Using the prospective National Comprehensive Cancer Network Colorectal Cancer Database, we determined treatment patterns for 976 patients with stage II-III rectal cancer who received pelvic radiation therapy at contributing centers between 2005 and 2011...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556577/obsessive-compulsive-disorder-after-therapy-for-an-optic-pathway-glioma
#10
Diana Guzman, Eeva Edds, Soumen Khatua, Susan L McGovern, Rhonda Robert
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556576/external-beam-radiation-therapy-for-advanced-unresectable-malignant-paraganglioma-and-pheochromocytoma
#11
William Breen, Irina Bancos, William F Young, Keith C Bible, Nadia N Laack, Robert L Foote, Christopher L Hallemeier
Purpose/Objectives: To evaluate the role of external beam radiation therapy (EBRT) for treatment of malignant paraganglioma (PGL) and pheochromocytoma (PCC). Methods and materials: A retrospective review was performed of all patients with malignant PGL/PCC treated with EBRT at our institution between 1973 and 2015. Local control (LC) per treated lesion and overall survival were estimated using the Kaplan-Meier method. Toxicities were scored using the Common Toxicity Criteria for Adverse Events (AE), version 4...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556575/pentoxifylline-and-vitamin-e-drug-compliance-after-adjuvant-breast-radiation-therapy
#12
Justin M Famoso, Brady Laughlin, Ali McBride, Victor J Gonzalez
Purpose: Breast fibrosis is a common late effect after therapeutic irradiation that can result in pain, poor cosmesis, and functional impairment. Randomized trials have demonstrated that radiation fibrosis may be preventable with a medication regimen of pentoxifylline and vitamin E. This study investigates patient compliance with pentoxifylline therapy while examining possible correlations to compliance. Methods and materials: We identified 90 patients who were prescribed pentoxifylline (400 mg 3 times daily) and vitamin E (400 IU once daily) after adjuvant breast radiation...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556574/lymphangioleiomyomatosis-a-new-relative-contraindication-for-breast-conservation-therapy
#13
Matthew L Mallory, Melissa P Mitchell
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556573/predictors-of-radiation-induced-acute-skin-toxicity-in-breast-cancer-at-a-single-institution-role-of-fractionation-and-treatment-volume
#14
Arti Parekh, Avani D Dholakia, Daniel J Zabranksy, Fariba Asrari, Melissa Camp, Mehran Habibi, Richard Zellars, Jean L Wright
Purpose: The associations among radiation fractionation, body mass index (BMI), and acute skin toxicity with adjuvant radiation for breast cancer is of increasing interest. This study evaluated the rate of grade ≥2 dermatitis and moist desquamation (MD) in patients with a high BMI who were treated to the breast or chest wall to understand the role of radiation target, fractionation regimen, and BMI. Methods and materials: We retrospectively evaluated 280 patients treated with adjuvant radiation for breast cancer after up-front surgery...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556572/the-pervasive-crisis-of-diminishing-radiation-therapy-access-for-vulnerable-populations-in-the-united-states-part-2-american-indian-patients
#15
Shearwood McClelland, Jennifer Leberknight, B Ashleigh Guadagnolo, C Norman Coleman, Daniel G Petereit
Introduction: American Indian/Alaska Native (AI/AN) patients with cancer disproportionally present with more advanced stages of disease and have the worst cancer-specific survival rates of any racial/ethnic group in the United States. The presence of disparities in radiation therapy (RT) access for AI/AN patients has rarely been examined. Methods and materials: National Cancer Institute (NCI) initiatives toward addressing AI/AN disparities were examined. Additionally, an extensive PubMed literature search for studies investigating RT access disparities in AI/AN patients was performed...
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29556571/impact-of-care-disparities-in-radiation-oncology
#16
EDITORIAL
Tasneem Kaleem, Grace Li Smith, Robert C Miller
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204531/axillary-lymph-node-coverage-with-3-dimensional-tangential-field-irradiation-and-correlation-with-heart-and-lung-dose
#17
Geraldine Jacobson, Nicole Bunda-Randall, Sijin Wen, Matthew Miller
Purpose: The American College of Surgeons Oncology Group Z0011 trial indicated no benefit from axillary lymph node (LN) dissection after a positive sentinel LN biopsy in patients receiving breast irradiation, suggesting that level I-II LNs were covered in tangential fields. Methods and materials: We evaluated 50 computed tomography-based tangential breast plans and contoured level I-III axillary LNs using the Radiation Therapy Oncology Group guidelines. The volumes of level I-III LN regions covered by 90% and 95% of the prescription dose (PD) were calculated and correlated with the V20 ipsilateral lung and mean heart dose...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204530/hippocampal-dose-volume-histogram-predicts-hopkins-verbal-learning-test-scores-after-brain-irradiation
#18
Catherine Okoukoni, Emory R McTyre, Diandra N Ayala Peacock, Ann M Peiffer, Roy Strowd, Christina Cramer, William H Hinson, Steve Rapp, Linda Metheny-Barlow, Edward G Shaw, Michael D Chan
Purpose: Radiation-induced cognitive decline is relatively common after treatment for primary and metastatic brain tumors; however, identifying dosimetric parameters that are predictive of radiation-induced cognitive decline is difficult due to the heterogeneity of patient characteristics. The memory function is especially susceptible to radiation effects after treatment. The objective of this study is to correlate volumetric radiation doses received by critical neuroanatomic structures to post-radiation therapy (RT) memory impairment...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204529/late-small-bowel-toxicity-after-aggressive-abdominopelvic-intensity-modulated-radiation-therapy
#19
Andrew Ling, Eli Furhang, Shannon N Ryemon, Ronald D Ennis
Purpose: We retrospectively analyzed late small bowel toxicity in patients who received abdominal or pelvic intensity modulated radiation therapy (IMRT) to the small bowel with a maximum dose greater than the generally accepted maximal tolerable dose of 45 Gy. Methods and materials: All patients (N = 94) who received IMRT with a point dose of at least 45 Gy to tightly contoured small bowel between 2005 and 2014 at our institution were included. The median prescribed treatment dose was 70...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204528/serum-testosterone-changes-in-patients-treated-with-radiation-therapy-alone-for-prostate-cancer-on-nrg-oncology-rtog-9408
#20
R Charles Nichols, Chen Hu, Jean-Paul Bahary, Kenneth L Zeitzer, Luis Souhami, Mark H Leibenhaut, Marvin Rotman, Elizabeth M Gore, Alexander G Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U Jones, Howard Sandler
Objectives: We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials: Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm...
October 2017: Advances in Radiation Oncology
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