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Advances in Radiation Oncology

Jesus D Gonzalez-Lugo, Rafi Kabarriti, Ioannis Mantzaris
No abstract text is available yet for this article.
October 2018: Advances in Radiation Oncology
Lauren E Colbert, Neal Rebueno, Shalini Moningi, Sam Beddar, Gabriel O Sawakuchi, Joseph M Herman, Albert C Koong, Prajnan Das, Emma B Holliday, Eugene J Koay, Cullen M Taniguchi
Purpose: There are limited treatment options for locally advanced, unresectable pancreatic cancer (LAPC) and no likelihood of cure without surgery. Radiation offers an option for local control, but radiation dose has previously been limited by nearby bowel toxicity. Advances in on-board imaging and treatment planning may allow for dose escalation not previously feasible and improve local control. In preparation for development of clinical trials of dose escalation in LAPC, we undertook a dosimetric study to determine the maximum possible dose escalation while maintaining known normal tissue constraints...
October 2018: Advances in Radiation Oncology
Jihun Kim, Yang-Kyun Park, David Edmunds, Kevin Oh, Gregory C Sharp, Brian Winey
Purpose: This study aimed to develop a linac-mounted kilovoltage (kV) projection streaming-based tracking method for vertebral targets during spine stereotactic radiation surgery and evaluate the clinical feasibility of the proposed spine tracking method. Methods and materials: Using real-time kV projection streaming within XVI (Elekta XVI), kV-projection-based tracking was applied to the target vertebral bodies. Two-dimensional in-plane patient translation was calculated via an image registration between digitally reconstructed radiographs (DRRs) and kV projections...
October 2018: Advances in Radiation Oncology
Giovanna Dipasquale, Thomas Zilli, Claudio Fiorino, Michel Rouzaud, Raymond Miralbell
Purpose: This study aimed to assess the impact of radiation dose on rectal toxicity after salvage external beam radiation therapy (EBRT) with or without a brachytherapy boost for exclusive local failures after the primary EBRT for prostate cancer. Methods and materials: Fourteen patients with no severe residual late toxicity after primary EBRT ± brachytherapy were reirradiated after a median time interval of 6.1 years. The median normalized total dose in 2 Gy fractions (NTD2Gy , α/β ratio = 1...
October 2018: Advances in Radiation Oncology
Molly M McCulloch, Daniel G Muenz, Matthew J Schipper, Michael Velec, Laura A Dawson, Kristy K Brock
Purpose: This study aimed to analyze the potential clinical impact of the differences between planned and accumulated doses on the development and use of normal tissue complication probability (NTCP) models. Methods and Materials: Thirty patients who were previously treated with stereotactic body radiation therapy for liver cancer and for whom the accumulated dose was computed were assessed retrospectively. The linear quadratic equivalent dose at 2 Gy per fraction and generalized equivalent uniform dose were calculated for planned and accumulated doses...
October 2018: Advances in Radiation Oncology
Noah S Kalman, Geoffrey D Hugo, Jenna M Kahn, Sherry S Zhao, Nuzhat Jan, Rebecca N Mahon, Elisabeth Weiss
Purpose: Radiographic lung changes after stereotactic body radiation therapy (SBRT) vary widely between patients. Standardized descriptions of acute (≤6 months after treatment) and late (>6 months after treatment) benign lung changes have been proposed but the reliable application of these classification systems has not been demonstrated. Herein, we examine the interobserver reliability of classifying acute and late lung changes after SBRT. Methods and materials: A total of 280 follow-up computed tomography scans at 3, 6, and 12 months post-treatment were analyzed in 100 patients undergoing thoracic SBRT...
October 2018: Advances in Radiation Oncology
Sanders Chang, Meng Ru, Erin L Moshier, Madhu Mazumdar, Doran Ricks, Nathan E Goldstein, Juan P Wisnivesky, Kavita V Dharmarajan
Purpose: Treatment burdens and toxicities related to palliative radiation therapy (RT) may lead to unplanned hospital admissions (UHAs). The likelihood for these toxicities may be related to treatment technique. We compared rates of UHA between patients receiving nonconformal (2-dimensional) and conformal (3-dimensional or higher) radiation treatments to bone metastases involving the vertebral column. Methods and materials: We retrospectively analyzed patients treated with RT for bone metastases at a single tertiary care center between 2010 and 2017...
October 2018: Advances in Radiation Oncology
Tommy Sheu, Sarah A Milgrom, Therese Y Andraos, Jillian R Gunther, Linda Chi, Loretta Nastoupil, Nathan Fowler, Yasuhiro Oki, Michelle A Fanale, Luis E Fayad, Fredrick Hagemeister, Sattva S Neelapu, L Jeffrey Medeiros, Chitra Hosing, Yago Nieto, Sairah Ahmed, Amin M Alousi, Bouthaina Dabaja, Chelsea C Pinnix
Background: For patients with primary diffuse large B-cell lymphoma of the central nervous system (PCNSL), whole-brain radiation therapy (WBRT) to doses of ≥45 Gy are often given after a partial response (PR) to methotrexate-based induction chemotherapy. We conducted an exploratory analysis to determine whether lower-dose WBRT, given with a boost to sites of persistent disease, might be a reasonable alternative. Methods and materials: We retrospectively reviewed the records of 22 patients with PCNSL who received WBRT, with or without a boost, after methotrexate-based induction chemotherapy...
October 2018: Advances in Radiation Oncology
Avinash R Chaurasia, Kelly J Sun, Christopher Premo, Timothy Brand, Brent Tinnel, Stacie Barczak, John Halligan, Michael Brown, Dusten Macdonald
Purpose: The aim of this study is to quantify and describe the feasibility, clinical outcomes, and patient-reported outcomes of reduced planning target volume (PTV) margins for prostate cancer treatment using real-time, continuous, intrafraction monitoring with implanted radiation frequency transponder beacons. Methods and materials: For this prospective, nonrandomized trial, the Calypso localization system was used for intrafraction target localization in 31 patients with a PTV margin reduced to 2 mm in all directions...
October 2018: Advances in Radiation Oncology
Diego A S Toesca, Amanda J Koong, Rie von Eyben, Albert C Koong, Daniel T Chang
Purpose: This study aimed to report on our institutional experience in the use of stereotactic body radiation therapy (SBRT) for the treatment of adrenal gland metastases. Specifically, we examined the outcomes and toxicity from this treatment modality on adjacent organs at risk. Methods and Materials: Data were retrieved from patients with adrenal metastases who were treated with SBRT between 2008 and 2017. Patients with primary adrenal malignancies were excluded...
October 2018: Advances in Radiation Oncology
Omar Abdel-Rahman, Hesham M Elhalawani, Pamela K Allen, Emma B Holliday
Purpose: Preoperative short-course radiation therapy (SCRT) for patients with nonmetastatic rectal adenocarcinoma has been studied in European trials, but is not often used in the United States. We aim to describe the utilization of preoperative SCRT among patients with nonmetastatic rectal cancer in the National Cancer Database and describe factors associated with its use. Methods and materials: The National Cancer Database was queried for patients treated with preoperative radiation therapy followed by surgery for nonmetastatic rectal adenocarcinoma between 2004 and 2014...
October 2018: Advances in Radiation Oncology
Zhi Cheng, Lauren M Rosati, Linda Chen, Omar Y Mian, Yilin Cao, Marta Villafania, Minoru Nakatsugawa, Joseph A Moore, Scott P Robertson, Juan Jackson, Amy Hacker-Prietz, Jin He, Christopher L Wolfgang, Matthew J Weiss, Joseph M Herman, Amol K Narang, Todd R McNutt
Purpose: For patients with localized pancreatic cancer (PC) with vascular involvement, prediction of resectability is critical to define optimal treatment. However, the current definitions of borderline resectable (BR) and locally advanced (LA) disease leave considerable heterogeneity in outcomes within these classifications. Moreover, factors beyond vascular involvement likely affect the ability to undergo resection. Herein, we share our experience developing a model that incorporates detailed radiologic, patient, and treatment factors to predict surgical resectability in patients with BR and LA PC who undergo stereotactic body radiation therapy (SBRT)...
October 2018: Advances in Radiation Oncology
Garrett Jensen, Randa Tao, Cathy Eng, John M Skibber, Miguel Rodriguez-Bigas, George J Chang, Y Nancy You, Brian K Bednarski, Bruce D Minsky, Eugene Koay, Cullen Taniguchi, Sunil Krishnan, Prajnan Das
Purpose: Previous studies have reported that hyperfractionated accelerated reirradiation can be used as part of multimodality treatment of locally recurrent rectal cancer with acceptable toxicity and promising outcomes. The purpose of this study was to evaluate the outcomes and toxicity of hyperfractionated accelerated reirradiation for patients with primary rectal adenocarcinoma and a history of prior pelvic radiation for other primary malignancies. Methods and materials: We identified 10 patients with a prior history of pelvic radiation for other primary malignancies who were treated with hyperfractionated accelerated reirradiation for primary rectal adenocarcinoma...
October 2018: Advances in Radiation Oncology
Simeng Zhu, Xiaofeng Yang, Karen M Xu, Jiwoong Jason Jeong, Mohammad K Khan
No abstract text is available yet for this article.
October 2018: Advances in Radiation Oncology
Colette J Shen, Megan N Kummerlowe, Kristin J Redmond, Juan Carlos Martinez-Gutierrez, Syed Muhammad Usama, Matthias Holdhoff, Stuart A Grossman, John J Laterra, Roy E Strowd, Lawrence R Kleinberg
Purpose: Reirradiation for recurrent glioma remains controversial without knowledge of optimal patient selection, dose, fractionation, and normal tissue tolerances. We retrospectively evaluated outcomes and toxicity after conventionally fractionated reirradiation for recurrent high-grade glioma, along with the impact of concurrent chemotherapy. Methods and materials: We conducted a retrospective review of patients reirradiated for high-grade glioma recurrence between 2007 and 2016 (including patients with initial low-grade glioma)...
October 2018: Advances in Radiation Oncology
Wietske C M Schimmel, Karin Gehring, Daniëlle B P Eekers, Patrick E J Hanssens, Margriet M Sitskoorn
Purpose: Stereotactic radiation surgery (SRS) is increasingly applied in patients with brain metastases (BM) and is expected to have fewer adverse effects on cognitive functioning than whole brain radiation therapy (WBRT). Patients with BM are often confronted with a relatively short life expectancy, and the prevention or delay of cognitive decline to maintain quality of life is a clinically and highly relevant treatment goal. This review systematically and specifically evaluates the current literature on the cognitive effects of SRS in patients with BM...
October 2018: Advances in Radiation Oncology
Ingrid Digernes, Endre Grøvik, Line B Nilsen, Cathrine Saxhaug, Oliver Geier, Edmund Reitan, Dag Ottar Sætre, Birger Breivik, Timothy Reese, Kari Dolven Jacobsen, Åslaug Helland, Kyrre Eeg Emblem
Purpose: This study aimed to investigate the hemodynamic status of cerebral metastases prior to and after stereotactic radiation surgery (SRS) and to identify the vascular characteristics that are associated with the development of pseudoprogression from radiation-induced damage with and without a radionecrotic component. Methods and materials: Twenty-four patients with 29 metastases from non-small cell lung cancer or malignant melanoma received SRS with dose of 15 Gy to 25 Gy...
October 2018: Advances in Radiation Oncology
Nicholas Courtier, Tina Gambling, Peter Barrett-Lee, Malcolm D Mason
Purpose: This study aimed to explore the associations between dose-volume parameters of localized breast irradiation, longitudinal interleukin-6 soluble receptor (sIL-6R), and leukocyte counts as markers of an immune-mediated response and fatigue as a centrally-driven behavior. Methods and Materials: This prospective cohort study recruited 100 women who were diagnosed with stage 0-IIIa breast cancer, prescribed 40 Gy in 15 fractions over 3 weeks adjuvant radiation therapy, and had no prior or concurrent chemotherapy...
October 2018: Advances in Radiation Oncology
Gunilla Pietsch, Tobias Anzeneder, Harald Bruckbauer, Michael Zirbs, Jan Gutermuth, Heidelore Hofmann, Knut Brockow, Tilo Biedermann, Johannes Ring, Bernadette Eberlein
Purpose: This study aimed to assess the safety, efficacy, and patient satisfaction of superficial radiation therapy in the treatment of Peyronie's disease (PD) in a retrospective analysis. Methods and materials: We performed a retrospective analysis of 83 patients who underwent radiation therapy between 1999 and 2008 with 8 fractions of 4 Gy over a period of 6 months. With a mean follow-up time of 52 months, patients responded to a comprehensive questionnaire that covered patient characteristics, disease duration before radiation therapy, course of disease, treatment response, side effects, and patient satisfaction...
October 2018: Advances in Radiation Oncology
Ariel E Marciscano, Daniel L J Thorek
The intersection of immunotherapy and radiation oncology is a rapidly evolving area of preclinical and clinical investigation. The strategy of combining radiation and immunotherapy to enhance local and systemic antitumor immune responses is intriguing yet largely unproven in the clinical setting because the mechanisms of synergy and the determinants of therapeutic response remain undefined. In recent years, several noninvasive molecular imaging approaches have emerged as a platform to interrogate the tumor immune microenvironment...
October 2018: Advances in Radiation Oncology
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