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Dermatopathology (Basel, Switzerland)

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https://www.readbyqxmd.com/read/29594106/gangrenous-chickenpox-with-atypical-clinical-and-histopathological-findings
#1
Leonardo Bianchi, Stefano Simonetti, Katharina Hansel, Franco Baldelli, Elisabetta Schiaroli, Luca Stingeni
No abstract text is available yet for this article.
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29594105/neutrophilic-dermatoses-in-autoimmune-diseases-report-of-two-cases-associated-with-autoimmune-thyroiditis
#2
Angelo Cassisa
The term "neutrophilic dermatoses" includes a rare inflammatory pattern characterized by neutrophil-rich cutaneous infiltrate. Both innate and adaptive immune pathways may be involved in neutrophil recruitment. Occasionally, neutrophilic dermatoses may occur in association with autoimmune thyroiditis. Pathogenetic aspects of this autoimmune disorder may elucidate their possible connection. Two exemplificative cases are taken as a pretext for a short review of this topic.
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29594104/lymphocytic-lobular-panniculitis-a-diagnostic-challenge
#3
Silvia Alberti-Violetti, Emilio Berti
No abstract text is available yet for this article.
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29457000/dysplastic-nevus-a-fake-lesion
#4
Guido Collina
No abstract text is available yet for this article.
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456999/a-53-year-old-male-with-relapsed-diffuse-large-b-cell-lymphoma-on-chemotherapy-with-a-new-leg-lesion
#5
Connie R Shi, Sarah N Robinson, Avery LaChance, Martin C Mihm, Daniela Kroshinsky
Patients with underlying malignancy who develop new skin findings while acutely ill often require skin biopsy for histologic evaluation and/or culture to reach a diagnosis. Here, we present the case of a 53-year-old male with relapsed diffuse large B-cell lymphoma on chemotherapy who developed new skin lesions on the leg. On exam, there were 2 nickel-sized, erythematous to violaceous round plaques with central necrotic cores on the right lower leg with relatively nonspecific clinical features for which the initial differential diagnosis was broad...
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456998/a-12-month-old-healthy-girl-with-a-new-oral-ulcer-and-chronic-diaper-rash
#6
Hannah Song, Johanna S Song, Elizabeth B Wallace, Leonard B Kaban, Mary S Huang, Stefan Kraft, Martin C Mihm, Daniela Kroshinsky
A 12-month-old healthy girl presented with a chronic diaper rash. Physical examination demonstrated crusting of the scalp, erythematous papules with surrounding petechiae on the lower abdomen, and an intraoral palatal ulcer. Further imaging demonstrated bone involvement. Histopathologic examination of involved skin and the intraoral ulcer demonstrated epithelioid histiocytes with "coffee bean-shaped" nuclei, staining positive for CD1a and langerin by immunohistochemistry, consistent with Langerhans cell histiocytosis (LCH)...
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456997/a-71-year-old-female-with-myocardial-infarction-and-long-standing-ulcers-on-the-thigh
#7
Eduardo De Flammineis, Patrick M Mulvaney, Stefan Kraft, Martin C Mihm, Shinjita Das, Daniela Kroshinsky
Calciphylaxis is most commonly encountered in patients with end-stage renal disease; however, it is increasingly observed in nonuremic patients as well. It is important to consider and diagnose nonuremic calciphylaxis early, as prompt treatment and mitigation of associated risk factors is essential to improve long-term outcomes for these patients. Here, we present the case of a 71-year-old woman with atrial fibrillation on warfarin, but without renal disease, who presented with two long-standing ulcers on her thigh and was diagnosed with the aid of biopsy with calciphylaxis...
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456996/a-65-year-old-male-with-primary-central-nervous-system-diffuse-large-b-cell-lymphoma-on-nivolumab-with-oral-mucositis-and-targetoid-plaques
#8
Severine Cao, Pooyan Rohani, Rosalynn M Nazarian, Daniela Kroshinsky
Background/Aims: The development of programmed cell death-1 (PD-1) inhibitors has greatly improved patient outcomes in the treatment of a variety of advanced malignancies. These novel immunotherapies are not without adverse effects, the most common of which are dermatologic. Methods: We report our experience with an atypical erythema multiforme-like eruption in a patient with primary central nervous system diffuse large B-cell lymphoma treated with nivolumab. Results: The patient presented with oral mucositis and scattered erythematous papules which progressed to targetoid purpuric plaques with hyperkeratotic centers...
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456995/a-25-year-old-male-with-orogenital-ulcers-rash-and-difficulty-swallowing
#9
Lauren N Ko, Allireza Alloo, William M Lin, Mai P Hoang, Daniela Kroshinsky
A 25-year-old otherwise healthy male presented with new-onset odynophagia, rash, and orogenital ulcers. Despite treatment with antibiotics for presumed bacterial pharyngitis, the patient remained symptomatic, with abnormal vital signs and laboratory values. Upon dermatology consultation and histopathologic correlation, he was diagnosed with Behçet disease. Behçet disease is a rare rheumatologic condition that presents with recurrent oral ulcers and varying degrees of ophthalmic, neurologic, cardiac, and vascular disease...
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29456994/benign-cutaneous-peripheral-nerve-sheath-tumor-with-hybrid-features-report-of-two-cases-with-schwannoma-perineurioma-and-schwannoma-neurofibroma-components
#10
Shirien Shanouda, Gürkan Kaya
Hybrid benign peripheral nerve sheath tumors are rare tumors exhibiting areas of more than one neural neoplasm such as schwannoma/neurofibroma, neurofibroma/perineurioma, or schwannoma/perineurioma. These tumors usually arise in the skin of the extremities and trunk, and less commonly affect extracutaneous sites. Here we report two cases of these tumors exhibiting hybrid features of schwannoma/perineurioma and schwannoma/neurofibroma located in the scalp and the ankle, respectively.
January 2017: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/28232908/a-case-of-adrenergic-urticaria-associated-with-vitiligo
#11
Caroline Lang, Gürkan Kaya
Adrenergic urticaria is a rare form of urticaria, induced by a stress-induced concomitant release of epinephrine and norepinephrine. Here we describe the case of a 60-year-old female patient presenting with disseminated erythematous papules surrounded by a white halo and vitiligo lesions on the hands, arms, and feet. Histological examination of one of the erythematous papules showed a dermal inflammatory infiltrate composed of lymphocytes and eosinophils of perivascular and interstitial localization. After 2 weeks of treatment with antihistamines, the lesions disappeared completely...
October 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27990417/multiple-eruptive-sebaceous-hyperplasia-secondary-to-cyclosporin-in-a-patient-with-bone-marrow-transplantation
#12
Begonia Cortés, Gürkan Kaya
Many cutaneous complications have been described in patients treated with cyclosporin. Alterations of the pilosebaceous unit such as hypertrichosis are particularly frequent. However, the occurrence of sebaceous hyperplasia is exceptional. These lesions seem to be specific to cyclosporin rather than secondary to immunosuppression. Here, we report an exceptional case of eruptive and disseminated sebaceous hyperplasia arising in a bone marrow transplant recipient only a few months after starting immunosuppressive treatment with cyclosporin...
October 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27904857/t-cadherin-expression-in-the-epidermis-and-adnexal-structures-of-normal-skin
#13
Stanislaw Buechner, Paul Erne, Therese J Resink
BACKGROUND: T-cadherin is an atypical glycosylphosphatidylinositol-anchored member of the cadherin superfamily of adhesion molecules. The role of T-cadherin in biology of the skin is poorly understood. Expression of T-cadherin in basal keratinocytes and dermal blood vessels of the healthy epidermis has been demonstrated, but studies on expression in skin appendages are rare. METHODS: We conducted an immunohistochemical analysis of T-cadherin expression in the epidermis and adnexal structures of normal skin...
September 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504447/injected-hyaluronidase-reduces-the-volume-of-exogenous-hyaluronate-fillers-in-mice-and-results-in-clinical-improvement-in-a-patient-with-pretibial-myxedema
#14
Sébastien Menzinger, Aysin Kaya, Jean-Hilaire Saurat, Gürkan Kaya
BACKGROUND: Hyaluronidases are essential for the breakdown of hyaluronate (HA) in tissues and may be used to prevent the adverse effects of HA fillers. OBJECTIVES: We explored the effect of hyaluronidase on exogenous and endogenous HA in vitro and in vivo. MATERIALS AND METHODS: HA fillers were incubated with different concentrations of hyaluronidase and visualized by electrophoresis. HA fillers were injected in the skin of hairless mice, and 4 h later hyaluronidase was injected in the papules of exogenous HA...
July 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504446/a-65-year-old-female-from-connecticut-with-orf-infection
#15
Jose Ramón Estela Cubells, Irwin Braverman, Michael Kashgarian, Rossitza Lazova
The virus, which causes orf and induces acute pustular skin lesions in sheep and goats, is transmissible to humans yet is rarely observed in North America. We present a case of a 65-year-old female farmer from Connecticut who contracted orf from her sheep. The clinical and histopathologic features, important to arrive at the correct diagnosis of this uncommon yet important infection, are described. We also discuss the benign nature of this condition and emphasize that treatment is not required.
April 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504445/lrig1-expression-in-human-sebaceous-gland-tumors
#16
Jöri Pünchera, Laurent Barnes, Gürkan Kaya
BACKGROUND: Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. In this study, we analyzed the Lrig1 expression in human sebaceous tumors. METHODS: Twenty-eight formalin-fixed paraffin-embedded sebaceous tumor specimens (7 sebaceous hyperplasias, 7 sebaceous adenomas, 10 sebaceomas and 4 sebaceous carcinomas) were stained with anti-Lrig1, anti-CD44v3 and anti-Ki67 antibody...
April 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504444/paraneoplastic-dermatosis-in-a-patient-with-anaplastic-large-cell-lymphoma-case-report-and-literature-review
#17
REVIEW
Travis Tagami, Omar Alhalabi, Nicholas Ward, James Huang
BACKGROUND/AIMS: Paraneoplastic dermatoses are skin disorders that are associated with malignancy. Anaplastic large T-cell lymphoma (ALTCL) has rarely been associated with paraneoplastic skin manifestations such as gangrenous foot ulcers and erythroderma. METHODS: We describe a case of ALTCL presenting as a large annular skin rash. The clinical picture, course, and treatment will be discussed along with current hypotheses on the mechanism of paraneoplastic syndromes...
April 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504443/bednar-tumor-an-uncommon-entity
#18
Gayathri P Amonkar, Asha Rupani, Ajay Shah, Ramesh Deshpande
Bednar tumor is an uncommon variant of dermatofibrosarcoma protuberans. Also known as pigmented dermatofibrosarcoma protuberans, this tumor is of intermediate grade. It is seen in adults and has a predisposition to affect the shoulder region. We report a rare case of Bednar tumor in a 40-year-old female patient. The diagnosis of Bednar tumor must be considered while reporting pigmented subcutaneous spindle cell lesions.
April 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27504442/slowly-growing-nodule-on-the-trunk-cutaneous-granular-cell-tumor
#19
Özge Gündüz, Gül Erkin, Banu Bilezikçi, Gökhan Adanalı
Granular cell tumor (GCT) is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. The tumor mostly presents with a symptomatic slowly growing solitary nodule and overlying normal skin; therefore, it is not always considered in the differential diagnosis. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a GCT at the histopathological examination. The neoplastic cells had centrally located nuclei and granular eosinophilic cytoplasm and stained positively for S100, neuron-specific enolase, and CD68 antibodies...
April 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27195266/diagnostic-approach-to-synovial-sarcoma-of-the-head-and-neck-illustrated-by-two-cases-arising-in-the-face-and-oral-cavity
#20
Primali Rukmal Jayasooriya, Lindumini Nayanahari Madawalagamage, Balapuwaduge Ranjit Rigorbert Nihal Mendis, Tommaso Lombardi
In the head and neck region, synovial sarcomas (SS) are rare tumours. We describe the diagnostic approach to SS based on two cases which developed in a 26-year-old male in the face and in a 53-year-old female on the alveolar mucosa of the upper jaw. The demographic profile of the patients was compatible with the literature. Histopathologically, both tumours presented as unencapsulated spindle cell tumours arranged into short fascicles. Although the chromosomal translocation of t(X;18)(p11.2;q11.2), transducin-like enhancer of split 1 (TLE-1) and SMARCB1 antibodies derived from gene expression studies are considered as the most sensitive makers to diagnose SS, these facilities were not available...
January 2016: Dermatopathology (Basel, Switzerland)
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