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Investigative and Clinical Urology

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https://www.readbyqxmd.com/read/28681040/the-renoprotective-effects-of-mannitol-and-udenafil-in-renal-ischemia-reperfusion-injury-model
#1
Yusuf Özlülerden, Cihan Toktaş, Hülya Aybek, Vural Küçükatay, Nilay Şen Türk, Ali Ersin Zumrutbas
PURPOSE: The aim of this study was to investigate and compare the effects of udenafil and mannitol in an experimental renal ischemia-reperfusion (I/R) injury model. MATERIALS AND METHODS: A total of 64 female Wister Albino rats were used. Right nephrectomy was performed in all groups. In the control group; I/R injury was not performed. In the I/R group; left renal pedicle was clamped for 45 minutes and then underwent 60 minutes and 24 hours of reperfusion. In the mannitol group; 1 mL 20% mannitol was given intravenously 15 minutes before clamping...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681039/prevalence-and-management-status-of-urologic-disease-in-geriatric-hospitals-in-south-korea-a-population-based-analysis
#2
Jungyo Suh, Khae Hawn Kim, Sang Heon Lee, Hyung Suk Kim, Young Ju Lee, Sang Rim Lee, Chang Wook Jeong
PURPOSE: This study aimed to investigate the prevalence and management status of urologic disease in geriatric hospitals in Korea. MATERIALS AND METHODS: We conducted population-based analyzed using cohort established by the National Health Insurance Service of Korea, which contains the medical insurance data of 1 million people from 2002 to 2013. The prevalence, prescription rate, and complication incidence of urologic disease in geriatric hospitals were compared with similar-sized general hospitals...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681038/mounting-resistance-of-uropathogens-to-antimicrobial-agents-a-retrospective-study-in-patients-with-chronic-bacterial-prostatitis-relapse
#3
Konstantinos Stamatiou, Nikolaos Pierris
PURPOSE: Despite recent progress in the management of chronic bacterial prostatitis (CBP), many cases relapse. Increased drug resistance patterns of responsible bacteria have been proposed as the most probable causative factor. Driven by the limited number of previous studies addressing this topic, we aimed to study whether antibiotic resistance increases in patients with CBP when relapse occurs. A secondary aim of this study was to determine the resistance patterns of responsible bacteria from patients with CBP...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681037/chronic-prostatitis-chronic-pelvic-pain-syndrome-in-adolescents-compared-with-that-in-young-adults
#4
Keon-Cheol Lee, In-Rae Cho
PURPOSE: Chronic prostatitis (CP)/chronic pelvic pain syndrome (CPPS) has been studied mainly in adults; reports in adolescents are rare. We compared the clinical characteristics of adolescent CP/CPPS patients with those of young adults. MATERIALS AND METHODS: We retrospectively analyzed 20 adolescents with CP/CPPS aged <20 years who visited our outpatient department from August 2005 to April 2012. The control group comprised 120 young adult CP/CPPS patients...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681036/additional-low-dose-antimuscarinics-can-improve-overactive-bladder-symptoms-in-patients-with-suboptimal-response-to-beta-3-agonist-monotherapy
#5
Jung Hyun Shin, Aram Kim, Myung-Soo Choo
PURPOSE: We aimed to assess the patient-reported outcome (PRO) and efficacy of add-on low-dose antimuscarinic therapy in over-active bladder (OAB) patients with suboptimal response to 4-week treatment with beta 3 agonist monotherapy (mirabegron, 50 mg). MATERIALS AND METHODS: We enrolled OAB patients with 4-week mirabegron (50 mg) treatment if the patients' symptoms improved, but not to a satisfactory extent (patient perception of bladder condition [PPBC] ≥4)...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681035/efficacy-of-magnetic-resonance-imaging-for-diagnosis-of-penile-fracture-a-controlled-study
#6
Erkin Saglam, Fatih Tarhan, Mustafa B Hamarat, Utku Can, Alper Coskun, Emre Camur, Kemal Sarica
PURPOSE: To evaluate the diagnostic value of magnetic resonance imaging (MRI) in patients with suspected penile fracture. MATERIALS AND METHODS: A total of 122 patients admitted to our inpatient clinic with a suspicion of penile fracture following a recent history of penile trauma and who underwent surgical exploration were included this study. A thorough physical examination, a detailed medical history, description of the trauma, and preoperative International Index of Erectile Function (IIEF) scores were obtained for each patient prior to surgery...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681034/how-do-we-diagnose-detrusor-underactivity-comparison-of-diagnostic-criteria-based-on-an-urodynamic-measure
#7
Seong Jin Jeong, Jung Keun Lee, Kwang Mo Kim, Harim Kook, Sung Yong Cho, Seung-June Oh
PURPOSE: To compare several contemporary urodynamic criteria for diagnosing detrusor underactivity (DU) and estimate how well they coincide with each other. MATERIALS AND METHODS: From our prospective urodynamic database we identified nonneurogenic lower urinary tract symptoms (LUTS) patients older than 60 years between 2003 and 2014. Patients were reclassified based on four and three contemporary criteria for DU among men and women. Each criterion was compared with the others using the McNemar test...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681033/the-impact-of-incontinence-etiology-on-artificial-urinary-sphincter-outcomes
#8
Adam R Miller, Brian J Linder, Laureano J Rangel, David Y Yang, Daniel S Elliott
PURPOSE: To evaluate the impact of incontinence etiology on artificial urinary sphincter (AUS) device outcomes. MATERIALS AND METHODS: We identified 925 patients who underwent primary AUS placement from 1983 to 2011. The etiology of incontinence was categorized as radical prostatectomy alone, radical prostatectomy with radiation, benign prostate resection, and those with cryotherapy as a salvage prostate cancer treatment. Hazard regression and competing risk analyses were used to determine the association of the etiology of incontinence with device outcomes...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681032/patient-and-nonradiographic-tumor-characteristics-predicting-lipid-poor-angiomyolipoma-in-small-renal-masses-introducing-the-bears-index
#9
Tyler M Bauman, Aaron M Potretzke, Alec J Wright, Joel M Vetter, Theodora A Potretzke, R Sherburne Figenshau
PURPOSE: To create a simple model using clinical variables for predicting lipid-poor angiomyolipoma (AML) in patients with small renal masses presumed to be renal cell carcinoma (RCC) from preoperative imaging. MATERIALS AND METHODS: A series of patients undergoing partial nephrectomy (PN) for renal masses ≤4 cm was identified using a prospectively maintained database. Patients were excluded if standard preoperative imaging was not consistent with RCC. Chi square and Mann-Whitney U analyses were used to evaluate differences in characteristics between patients with AML and other types of pathology...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681031/clinical-predictors-of-the-estimated-glomerular-filtration-rate-1-year-after-radical-nephrectomy-in-japanese-patients
#10
Shuichi Shimada, Hideo Saito, Yoshihide Kawasaki, Shinichi Yamashita, Hisanobu Adachi, Narihiko Kakoi, Takashige Namima, Masahiko Sato, Atsushi Kyan, Koji Mitsuzuka, Akihiro Ito, Takuhiro Yamaguchi, Yoichi Arai
PURPOSE: To evaluate renal function 1 year after radical nephrectomy (RN) for renal cell carcinoma, the preoperative predictors of postnephrectomy renal function were investigated by sex, and equations to predict the estimated glomerular filtration rate (eGFR) 1 year after RN were developed. MATERIALS AND METHODS: A total of 525 patients who underwent RN between May 2007 and August 2011 at Tohoku University Hospital and its affiliated hospitals were prospectively evaluated...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681030/novel-immunotherapy-in-metastatic-renal-cell-carcinoma
#11
REVIEW
Yang Hyun Cho, Myung Soo Kim, Ho Seok Chung, Eu Chang Hwang
Despite the rapid development of therapeutic modalities for metastatic renal cell carcinoma (mRCC) over the past decade to include a number of targeted antiangiogenic therapies and traditional immunotherapy, such as high-dose interleukin-2 and interferon-α, mRCC continues to be associated with poor prognosis. Currently, several novel immunotherapy agents, such as cancer vaccines, adoptive cell therapy, and checkpoint inhibitors, such as programmed cell death-1 (PD-1 present on T cells), one of its ligands (PD-L1 present on antigen-presenting cells and tumor cells), and cytotoxic T-lymphocyte-associated protein-4 pathways, are being studied in mRCC and are showing promise as important steps in the management of this disease...
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28681029/prostate-cancer-screening
#12
EDITORIAL
James Eastham
No abstract text is available yet for this article.
July 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612061/management-of-vesicoureteral-reflux-in-neurogenic-bladder
#13
REVIEW
Charlotte Q Wu, Israel Franco
Vesicoureteral reflux (VUR) is a significant risk factor for pyelonephritis and renal scarring. VUR can occur through a defective ureterovesical junction (UVJ) or an overwhelmed normal UVJ mechanism such as in bladder dysfunction of congenital, acquired, or behavioral etiology. There are numerous causes for the development of a neurogenic bladder from spinal dysraphisms to spinal cord trauma and even centrally based abnormalities in children with apparently normal motor function (inappropriately termed nonneurogenic neurogenic bladder)...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612060/aggressive-diagnosis-and-treatment-for-posterior-urethral-valve-as-an-etiology-for-vesicoureteral-reflux-or-urge-incontinence-in-children
#14
REVIEW
Hideo Nakai, Taiju Hyuga, Shina Kawai, Taro Kubo, Shigeru Nakamura
Vesicoureteral reflux (VUR) is one of the most common diseases in pediatric urology and classified into primary and secondary VUR. Although posterior urethral valve (PUV) is well known as a cause of the secondary VUR, it is controversial that minor urethral deformity recognized in voiding cystourethrography represents mild end of PUV spectrum and contributes to the secondary VUR. We have been studying for these ten years congenital urethral obstructive lesions with special attention to its urethrographic and endoscopic morphology as well as therapeutic response with transurethral incision...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612059/endoscopic-injection-therapy
#15
REVIEW
Sang Woon Kim, Yong Seung Lee, Sang Won Han
Since the U.S. Food and Drug Administration approved dextranomer/hyaluronic acid copolymer (Deflux) for the treatment of vesicoureteral reflux, endoscopic injection therapy using Deflux has become a popular alternative to open surgery and continuous antibiotic prophylaxis. Endoscopic correction with Deflux is minimally invasive, well tolerated, and provides cure rates approaching those of open surgery (i.e., approximately 80% in several studies). However, in recent years a less stringent approach to evaluating urinary tract infections (UTIs) and concerns about long-term efficacy and complications associated with endoscopic injection have limited the use of this therapy...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612058/vesicoureteral-reflux-and-continuous-prophylactic-antibiotics
#16
REVIEW
Ted Lee, John M Park
Vesicoureteral reflux (VUR) management must be tailored based on the risk for further infections and renal scarring, gender, likelihood of spontaneous resolution, and parental preferences. Because we now understand that sterile VUR is benign and most reflux spontaneously resolves over time, the initial approach in majority of children is non-surgical with continuous antibiotic prophylaxis (CAP) and correction of bladder and bowel dysfunction. Despite increasing utilization of CAP over the past four decades, the efficacy of antibiotic prophylaxis has been questioned due to conflicting results of studies plagued with design flaws and inadequate subject sample size...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612057/imaging-studies-and-biomarkers-to-detect-clinically-meaningful-vesicoureteral-reflux
#17
REVIEW
Michaella Maloney Prasad, Earl Y Cheng
The work-up of a febrile urinary tract infection is generally performed to detect vesicoureteral reflux (VUR) and its possible complications. The imaging modalities most commonly used for this purpose are renal-bladder ultrasound, voiding cystourethrogram and dimercapto-succinic acid scan. These studies each contribute valuable information, but carry individual benefits and limitations that may impact their efficacy. Biochemical markers are not commonly used in pediatric urology to diagnose or differentiate high-risk disease, but this is the emerging frontier, which will hopefully change our approach to VUR in the future...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612056/critical-appraisal-of-the-top-down-approach-for-vesicoureteral-reflux
#18
REVIEW
Ahmed Abdelhalim, Antoine E Khoury
Vesicoureteral reflux (VUR) has been linked to recurrent urinary tract infections (UTIs), renal scarring, hypertension, renal insufficiency and end-stage kidney disease. Different imaging strategies have been proposed to approach children presenting with UTI to sort out patients with significant VUR while minimizing patient morbidity, radiation exposure and financial burden. None of these imaging strategies is universally accepted. The"top-down approach" (TDA) aims at restricting the number of voiding cystourethrograms (VCUGs) and its associated morbidity while identifying patients with clinically-significant reflux...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612055/genetics-of-vesicoureteral-reflux-and-congenital-anomalies-of-the-kidney-and-urinary-tract
#19
REVIEW
Keum Hwa Lee, Heon Yung Gee, Jae Il Shin
The definition of congenital anomalies of the kidney and urinary tract (CAKUT) is the disease of structural malformations in the kidney and/or urinary tract containing vesicoureteral reflux (VUR). These anomalies can cause pediatric chronic kidney disease. However, the pathogenesis of CAKUT is not well understood, because identifying the genetic architecture of CAKUT is difficult due to the phenotypic heterogeneity and multifactorial genetic penetrance. We describe the current genetic basis and mechanisms of CAKUT including VUR via approaching the steps and signaling pathways of kidney developmental processes...
June 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28612054/pediatric-vesicoureteral-reflux-slow-but-steady-steps
#20
EDITORIAL
Yong Seung Lee, Sang Won Han
No abstract text is available yet for this article.
June 2017: Investigative and Clinical Urology
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