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Investigative and Clinical Urology

Hae Do Jung, Jong Chan Kim, Hyun Kyu Ahn, Joon Ho Kwon, Kichang Han, Woong Kyu Han, Man-Deuk Kim, Joo Yong Lee
Endoscopic combined intrarenal surgery (ECIRS) with simultaneous retrograde intrarenal surgery (RIRS) and percutaneous nephrolithotomy (PCNL) has been proposed as a new surgical treatment to overcome the disadvantage of RIRS and PCNL monotherapies in the treatment of renal stone. One of advantages of ECIRS is that it can increase stone-free rates in complex renal stone within single-session. Intermediate-supine position in real-time simultaneous ECIRS can prevent an anesthesiologic problem, and patient's burden is small even for long-term operation...
September 2018: Investigative and Clinical Urology
Kara E McAbee, Amy M Pearlman, Ryan P Terlecki
Purpose: Primary care providers harbor misconceptions regarding penile prosthetic surgery, largely overestimating the rate of infection. Rates of infection following surgery for primary placement and revision are estimated as 1% to 3% and 10% to 18%, respectively. Our objective was to determine the contemporary incidence of infection following inflatable penile prostheses surgery at an academic training center where surgeons-in-training are routinely involved. Materials and Methods: Review of a prospectively collected single-surgeon database was performed...
September 2018: Investigative and Clinical Urology
Jin Woo Kim, You Jin Lee, Jae-Wook Chung, Yun-Sok Ha, Jun Nyung Lee, Eun Sang Yoo, Tae Gyun Kwon, Bum Soo Kim
Purpose: Ureteroscopic lithotripsy (URS) is gaining popularity for the management of ureteral stones and even renal stones, with high efficacy and minimal invasiveness. Although this procedure is known to be safe and to have a low complication rate, febrile urinary tract infection (UTI) after URS is not rare. Therefore, we aimed to analyze the risk factors and causative pathogens of febrile UTI after URS. Materials and Methods: Between January 2013 and June 2015, 304 patients underwent URS for ureteral or renal stones...
September 2018: Investigative and Clinical Urology
Dai Hee Kim, Jung Hyun Shin, Se Young Choi, Dalsan You, Choung-Soo Kim, Hyung Keun Park
Purpose: Despite advances in flexible ureteroscopy, the high cost and long repair time of ureteroscopes limit their use in the urology. We compared the performance of a novel flexible ureteroscope (fURS) 'HF-EH' with that of the two contemporary fURSs 'URF-P6' and 'COBRA'. Materials and Methods: We compared in vitro measurements of deflection angle, irrigation flow rate, and image quality between HF-EH and URF-P6 while also inspecting renal collecting systems in five female pigs...
September 2018: Investigative and Clinical Urology
Manoj Kumar, Siddharth Pandey, Ajay Aggarwal, Deepanshu Sharma, Gaurav Garg, Samarth Agarwal, Ashish Sharma, Satyanarayan Sankhwar
Purpose: To see the 30-day unplanned readmission rates in patients underdoing endo-urological surgeries for upper urinary tract calculi we conducted this retrospective study at King George's Medical University, Lucknow, India. Unplanned readmissions not only add to healthcare costs but also are bothersome for the patients. There are many studies on 30-day unplanned readmissions in general surgical patients. Although similar studies have been done in certain urological procedures, no study has reported readmission rates or its risk factors in patients undergoing surgeries for upper urinary tract calculi...
September 2018: Investigative and Clinical Urology
Sahyun Pak, Myong Kim, Hanjong Ahn
Purpose: To evaluate longitudinal changes in health-related quality of life and satisfaction after radical prostatectomy for the treatment of prostate cancer in Korean men. Materials and Methods: Data from patients with localized prostate cancer who underwent radical prostatectomy between January 2012 and December 2013 were analyzed. Patients completed the Expanded Prostate Cancer Index Composite questionnaire at scheduled clinic visits (baseline and 1, 3, 6, and 12 months post-surgery)...
September 2018: Investigative and Clinical Urology
Aditya P Sharma, Ravimohan S Mavuduru, Girdhar S Bora, Sudheer K Devana, Shrawan K Singh, Arup K Mandal
Purpose: RENAL nephrometry score (RNS) was devised for deciding the approach for renal tumors. It is increasingly used in predicting perioperative outcomes with variable results. The actual difficulty encountered during surgery depends on a number of other variables. The main purpose of this prospective study was to identify these variables which are not addressed by current RNS. Materials and Methods: Forty-nine patients undergoing robotic nephron sparing surgery from January 2015 onward were included...
September 2018: Investigative and Clinical Urology
Patrick Betschart, Dominik Abt, Hans-Peter Schmid, Pascal Viktorin, Janine Langenauer, Valentin Zumstein
Purpose: This study was performed to assess readability of the most commonly used questionnaires in urology including a separate analysis of their single-items to identify questions that might be especially demanding for patients. Materials and Methods: The guidelines of the European Association of Urology were screened for recommended questionnaires. Readability was analyzed for complete questionnaires as well as their single-items separately using well established readability assessment tools, including Flesch-Kincaid grade level (FKGL), Simple Measure of Gobbledygook grade level (SMOG), Coleman-Liau Index (CLI), Gunning-Fog Index, and the Flesch Reading Ease formula...
September 2018: Investigative and Clinical Urology
Hyung Suk Kim, Ho Kyung Seo
Urothelial carcinoma (UC), originating in the bladder or upper urinary tract, is the most common histological type of cancer. Currently, platinum-based cytotoxic chemotherapy is the standard treatment for metastatic UC (mUC) and the preferred treatment option in the perioperative (neoadjuvant and/or adjuvant) setting of muscle invasive bladder cancer (MIBC). In addition, intravesical bacillus Calmette-Guerin immunotherapy or chemotherapy is applied as the adjuvant therapeutic option in non-muscle invasive bladder cancer (NMIBC) after transurethral resection, to prevent recurrence and progression...
September 2018: Investigative and Clinical Urology
Glen Gejerman, Patrick Ciccone, Martin Goldstein, Vincent Lanteri, Burton Schlecker, John Sanzone, Michael Esposito, Sergey Rome, Michael Ciccone, Eric Margolis, Robert Simon, Yijun Guo, Sri-Ram Pentakota, Hossein Sadeghi-Nejad
[This corrects the article on p. 423 in vol. 58.].
July 2018: Investigative and Clinical Urology
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
No abstract text is available yet for this article.
July 2018: Investigative and Clinical Urology
Eleftherios Spartalis, Diamantis I Tsilimigras, Stavros Sfoungaristos
No abstract text is available yet for this article.
July 2018: Investigative and Clinical Urology
Amy Marcia Pearlman, Alison Marie Rasper, Ryan Patrick Terlecki
Purpose: Rate of continence after artificial urinary sphincter (AUS) placement appears to decline with time. After appropriate workup to exclude inadvertent device deactivation, development of urge or overflow incontinence, and fluid loss, many assume recurrent stress urinary incontinence (rSUI) to be secondary to nonmechanical failure, asserting urethral atrophy as the etiology. We aimed to characterize the extent of circumferential urethral recovery following capsulotomy and that of pressure regulating balloon (PRB) material fatigue in men undergoing AUS revision for rSUI...
July 2018: Investigative and Clinical Urology
Yun-Sok Ha, Yeon-Yong Kim, Na Hee Yu, So Young Chun, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Tae Gyun Kwon
Purpose: Transient receptor potential melastatin member 7 (TRPM7), an ion channel and serine/threonine protein kinase, has been linked with distinct human malignancies. However, the role of TRPM7 in renal cell carcinoma (RCC) has not been investigated. The aim of this study is to determine whether TRPM7 regulates the migration and invasion of RCC cells. Its relationship with signal transduction pathways was also studied. Materials and Methods: The human RCC cell lines ACHN and SN12C were chosen for this study...
July 2018: Investigative and Clinical Urology
Amandeep Mahal, Nichole Young-Lin, Amy Dobberfuhl, Jaclyn Estes, Craig Vance Comiter
Purpose: To understand the therapeutic potential of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with a propensity to cause bladder mucosal proliferation, on interstitial cystitis (IC) in a rat model. Materials and Methods: Using a previously described animal model for IC, Sprague-Dawley rats were treated with biweekly cyclophosphamide injections (35 mg/kg) to induce cystitis. Animals were divided into 4 groups (n=6 for each group): IC plus daily sham saline gavage (IC+ Pio- ), IC plus daily pioglitazone gavage (15 mg/kg) (IC+ Pio+ ), normal rats with daily pioglitazone (IC- Pio+ ), and normal rats with neither IC nor pioglitazone (IC- Pio- or Control)...
July 2018: Investigative and Clinical Urology
Eda Dokumacioglu, Ozay Demiray, Ali Dokumacioglu, Arzu Sahin, Tugba Mazlum Sen, Soner Cankaya
Purpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease...
July 2018: Investigative and Clinical Urology
J Joshua Yune, Jim K Shen, Matthew A Pierce, Jeffrey S Hardesty, Joo Kim, Sam Siddighi
Purpose: Intravesical electrical stimulation treatment (IVES) has been successfully used to treat neurogenic bladder. We report the results of an observational study regarding the use of IVES for women with overactive bladder syndrome (OAB) and/or urgency urinary incontinence (UUI). Materials and Methods: IVES was performed in women with OAB (defined by frequency ≥8/day, nocturia ≥2/night, or ≥3 episodes of UUI on 3-day voiding diary) who failed prior medical therapy...
July 2018: Investigative and Clinical Urology
Kenneth Chen, Yu Guang Tan, Darren Tan, Gregory Pek, Hong Hong Huang, Soon Phang Allen Sim
Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications. Traditionally, nephrectomies were performed via the open approach in view of space constraints. We evaluate our institution's outcomes for laparoscopic nephrectomy (LN) for ADPKD. Materials and Methods: We retrospectively reviewed 33 patients with ADPKD who underwent nephrectomies from November 2005 to December 2016 at a tertiary institution...
July 2018: Investigative and Clinical Urology
Nornazirah Azizan, Firdaus Hayati, Nur Maya Sabrina Tizen, Wirda Indah Farouk, Noraidah Masir
Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor...
July 2018: Investigative and Clinical Urology
Yüksel Yılmaz, Mehmet Cemal Kahya, Fatma Hüsniye Dilek, Osman Köse, Serkan Özcan, Ertan Can, Yiğit Akın, Batuhan Ergani, Ahmet Selçuk Dindar
Purpose: To investigate the effect on recurrence of vaporization of the tumor surroundings and suspicious areas with a plasma-kinetic (PK) system after transurethral resection (TUR) of nonmuscle invasive bladder cancer. Materials and Methods: The study included 121 patients with a primary superficial bladder tumor who were randomized as those who underwent TUR with the PK system (Group 1, n=62) and those who underwent TUR with the monopolar system (Group 2, n=59)...
July 2018: Investigative and Clinical Urology
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