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Investigative and Clinical Urology

Glen Gejerman, Patrick Ciccone, Martin Goldstein, Vincent Lanteri, Burton Schlecker, John Sanzone, Michael Esposito, Sergey Rome, Michael Ciccone, Eric Margolis, Robert Simon, Yijun Guo, Sri-Ram Pentakota, Hossein Sadeghi-Nejad
[This corrects the article on p. 423 in vol. 58.].
July 2018: Investigative and Clinical Urology
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
No abstract text is available yet for this article.
July 2018: Investigative and Clinical Urology
Eleftherios Spartalis, Diamantis I Tsilimigras, Stavros Sfoungaristos
No abstract text is available yet for this article.
July 2018: Investigative and Clinical Urology
Amy Marcia Pearlman, Alison Marie Rasper, Ryan Patrick Terlecki
Purpose: Rate of continence after artificial urinary sphincter (AUS) placement appears to decline with time. After appropriate workup to exclude inadvertent device deactivation, development of urge or overflow incontinence, and fluid loss, many assume recurrent stress urinary incontinence (rSUI) to be secondary to nonmechanical failure, asserting urethral atrophy as the etiology. We aimed to characterize the extent of circumferential urethral recovery following capsulotomy and that of pressure regulating balloon (PRB) material fatigue in men undergoing AUS revision for rSUI...
July 2018: Investigative and Clinical Urology
Yun-Sok Ha, Yeon-Yong Kim, Na Hee Yu, So Young Chun, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Eun Sang Yoo, Tae Gyun Kwon
Purpose: Transient receptor potential melastatin member 7 (TRPM7), an ion channel and serine/threonine protein kinase, has been linked with distinct human malignancies. However, the role of TRPM7 in renal cell carcinoma (RCC) has not been investigated. The aim of this study is to determine whether TRPM7 regulates the migration and invasion of RCC cells. Its relationship with signal transduction pathways was also studied. Materials and Methods: The human RCC cell lines ACHN and SN12C were chosen for this study...
July 2018: Investigative and Clinical Urology
Amandeep Mahal, Nichole Young-Lin, Amy Dobberfuhl, Jaclyn Estes, Craig Vance Comiter
Purpose: To understand the therapeutic potential of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with a propensity to cause bladder mucosal proliferation, on interstitial cystitis (IC) in a rat model. Materials and Methods: Using a previously described animal model for IC, Sprague-Dawley rats were treated with biweekly cyclophosphamide injections (35 mg/kg) to induce cystitis. Animals were divided into 4 groups (n=6 for each group): IC plus daily sham saline gavage (IC+ Pio- ), IC plus daily pioglitazone gavage (15 mg/kg) (IC+ Pio+ ), normal rats with daily pioglitazone (IC- Pio+ ), and normal rats with neither IC nor pioglitazone (IC- Pio- or Control)...
July 2018: Investigative and Clinical Urology
Eda Dokumacioglu, Ozay Demiray, Ali Dokumacioglu, Arzu Sahin, Tugba Mazlum Sen, Soner Cankaya
Purpose: In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation. Materials and Methods: A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease...
July 2018: Investigative and Clinical Urology
J Joshua Yune, Jim K Shen, Matthew A Pierce, Jeffrey S Hardesty, Joo Kim, Sam Siddighi
Purpose: Intravesical electrical stimulation treatment (IVES) has been successfully used to treat neurogenic bladder. We report the results of an observational study regarding the use of IVES for women with overactive bladder syndrome (OAB) and/or urgency urinary incontinence (UUI). Materials and Methods: IVES was performed in women with OAB (defined by frequency ≥8/day, nocturia ≥2/night, or ≥3 episodes of UUI on 3-day voiding diary) who failed prior medical therapy...
July 2018: Investigative and Clinical Urology
Kenneth Chen, Yu Guang Tan, Darren Tan, Gregory Pek, Hong Hong Huang, Soon Phang Allen Sim
Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, and 20% of patients eventually require nephrectomies due to compressive symptoms or renal-related complications. Traditionally, nephrectomies were performed via the open approach in view of space constraints. We evaluate our institution's outcomes for laparoscopic nephrectomy (LN) for ADPKD. Materials and Methods: We retrospectively reviewed 33 patients with ADPKD who underwent nephrectomies from November 2005 to December 2016 at a tertiary institution...
July 2018: Investigative and Clinical Urology
Nornazirah Azizan, Firdaus Hayati, Nur Maya Sabrina Tizen, Wirda Indah Farouk, Noraidah Masir
Purpose: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. Materials and Methods: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January 2011 to June 2015 in 100 patients. Immunohistochemical staining of ER-beta and Ki67 was analyzed according to Gleason score categorized into prognostic groups of 1 to 5. Double-immunofluorescent staining of ER-beta and Ki67 was performed in a total of 20 cases to study the co-expression and the relationship between these markers within the same tumor...
July 2018: Investigative and Clinical Urology
Yüksel Yılmaz, Mehmet Cemal Kahya, Fatma Hüsniye Dilek, Osman Köse, Serkan Özcan, Ertan Can, Yiğit Akın, Batuhan Ergani, Ahmet Selçuk Dindar
Purpose: To investigate the effect on recurrence of vaporization of the tumor surroundings and suspicious areas with a plasma-kinetic (PK) system after transurethral resection (TUR) of nonmuscle invasive bladder cancer. Materials and Methods: The study included 121 patients with a primary superficial bladder tumor who were randomized as those who underwent TUR with the PK system (Group 1, n=62) and those who underwent TUR with the monopolar system (Group 2, n=59)...
July 2018: Investigative and Clinical Urology
Ghose Aruni, Ghose Amit, Prokar Dasgupta
No abstract text is available yet for this article.
July 2018: Investigative and Clinical Urology
Jungyo Suh, Khae Hawn Kim, Sang Heon Lee, Hyung Suk Kim, Young Ju Lee, Sang Rim Lee, Chang Wook Jeong
[This corrects the article on p. 281 in vol. 58.].
May 2018: Investigative and Clinical Urology
Sher Singh Yadav, Vivek Kumar Singh, Vinay Tomar, Neeraj Agarwal, Anil Gulani
Purpose: To report our initial experience with urethral reconstruction using a combined dorsal lingual mucosal graft (LMG) and ventral onlay preputial flap for long obliterative or near-obliterative strictures in circumcised patients. Materials and Methods: This was a retrospective study of 10 patients from January 2015 to June 2017 with long obliterative or near-obliterative anterior urethral strictures and circumcised prepuces. All patients underwent a combined approach using a dorsally LMG and a narrow preputial onlay flap ventrally to create a 26-30 Fr...
May 2018: Investigative and Clinical Urology
Sang Woon Kim, Yong Seung Lee, Young Jae Im, Sang Won Han
Purpose: The aim of this study was to report preliminary results of endoscopic treatment of vesicoureteral reflux in children with a single injection of a new bulking agent, cross-linked dextran and polymethylmethacrylate mixture. Materials and Methods: We performed a single-center, single surgeon, prospective, off-label study using polymethylmethacrylate/dextranomer to treat vesicoureteral reflux. All patients underwent endoscopic injection, followed by renal ultrasound and voiding cystourethrogram at 3 months postoperatively to identify de novo or worsening hydronephrosis and vesicoureteral reflux correction (to Grade 0 or I)...
May 2018: Investigative and Clinical Urology
Marc Colaco, Austin Hester, William Visser, Alison Rasper, Ryan Terlecki
Purpose: Performance of minimally-invasive surgery (MIS) is increasing relative to open surgery. We sought to compare the contemporary rates of short-term complications of open versus laparoscopic renal and ureteral surgery in pediatric patients. Materials and Methods: A retrospective cross-sectional analysis of the National Surgical Quality Improvement Program Pediatrics database was performed of all cases in 2014 identified using CPT procedure codes for nephrectomy, partial nephrectomy (PN), ureteroneocystostomy (UNC), and pyeloplasty, and reviewed for postoperative complications...
May 2018: Investigative and Clinical Urology
Won Yeol Cho, Seong Cheol Kim, Sun-Ouck Kim, Sungchan Park, Sang Don Lee, Jae Min Chung, Kyung Do Kim, Du Geon Moon, Young Sig Kim, Jun Mo Kim
Purpose: This study aimed to demonstrate a method to easily assess bladder capacity using knowledge of day-time voided volumes, which can be obtained even from patients with nocturnal enuresis where the first morning void cannot accurately predict the bladder capacity due to bladder emptying overnight. Materials and Methods: We evaluated 177 healthy children from 7 Korean medical centres entered the study between January 2008 and January 2009. Voided volumes measured for more than 48 hours were recorded in the frequency volume chart (FVC)...
May 2018: Investigative and Clinical Urology
Tommaso Cai, Francesco Tessarolo, Iole Caola, Federico Piccoli, Giandomenico Nollo, Patrizio Caciagli, Sandra Mazzoli, Alessandro Palmieri, Paolo Verze, Gianni Malossini, Vincenzo Mirone, Truls E Bjerklund Johansen
Purpose: Prostate calcifications are a common finding during transrectal prostate ultrasound in both healthy subjects and patients, but their etiopathogenesis and clinical significance are not fully understood. We aimed to establish a new methodology for evaluating the role of microbial biofilms in the genesis of prostate calcifications. Materials and Methods: Ten consecutive patients who had undergone radical prostatectomy were enrolled in this study. All of the patients presented with prostate calcifications during transrectal ultrasound evaluation before surgery and underwent Meares-Stamey tests and clinical evaluation with the National Institutes of Health Chronic Prostatitis Symptom Index and the International Prostate Symptom Score...
May 2018: Investigative and Clinical Urology
Chirag Gupta, Arun Chinchole, Rupin Shah, Hemant Pathak, Deepa Talreja, Ankit Kayal
Purpose: Many studies have shown improved semen parameters after varicocele surgery; however, the benefit in terms of improved pregnancy rates and live births is still disputed in cases of severe oligoasthenozoospermia (OAS). The present study evaluated the outcome of microscopic subinguinal varicocelectomy in terms of the spontaneous pregnancy rate in patients with severe OAS. Materials and Methods: This was a retrospective, observational, analytic study of 56 men with OAS who underwent microscopic varicocelectomy at our center between 2008 and 2015...
May 2018: Investigative and Clinical Urology
Graham Luke Machen, Stephanie E Harris, Erin T Bird, Monica L Brown, Dale A Ingalsbe, Milaida M East, Michelle Reyes, Thomas J Kuehl
Purpose: Cryopreservation of sperm from human semen has been available since the 1950s. The actual utilization of available cryopreservation technology has been infrequently reported. We set out to examine the utilization and outcomes of cryopreserved sperm cells based on the indication for storage. Materials and Methods: A dataset was developed from retrospective review. The purposes for cryopreservation, eventual utilization, and outcomes of use for insemination were recorded...
May 2018: Investigative and Clinical Urology
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