Read by QxMD icon Read

Medicines (Basel, Switzerland)

Yuanjun Deng, Kairui Tang, Runsen Chen, Yajie Liu, Huan Nie, Hong Wang, Yupei Zhang, Qinhe Yang
Background: In traditional Chinese medicine, the Shugan-Jianpi recipe is often used in the treatment of nonalcoholic fatty liver disease (NAFLD). This study aimed to explore the mechanism of the Shugan-Jianpi recipe in relation to rats with NAFLD induced by a high-fat diet. Methods: Rats were randomly divided into eight groups: normal group (NG), model group (MG), low-dose Chaihu⁻Shugan⁻San group (L-CG), high-dose Chaihu⁻Shugan⁻San group (H-CG), low-dose Shenling⁻Baizhu⁻San group (L-SG), high-dose Shenling⁻Baizhu⁻San group (H-SG), low dose of integrated-recipes group (L-IG), and high dose of integrated-recipes group (H-IG)...
September 19, 2018: Medicines (Basel, Switzerland)
Ray Marks
Background : Aging is commonly accepted as a time period of declining heath in most cases. This review aimed to examine the research base concerning the use of the term 'successful aging', a process and outcome deemed desirable, but challenging to attain. A second was to provide related information to demonstrate how health professionals as well as individuals can aim for a 'successful aging' process and outcome, despite the presence of disabling osteoarthritis. Methods : Information specifically focusing on 'successful aging' and the concept of improving opportunities for advancing 'successful aging' despite osteoarthritis was sought...
September 19, 2018: Medicines (Basel, Switzerland)
Anh V Le, Tien T Huynh, Sophie E Parks, Minh H Nguyen, Paul D Roach
Background: Gac ( Momordica cochinchinensis Spreng) seeds have long been used in traditional medicine as a remedy for numerous conditions due to a range of bioactive compounds. This study investigated the solvent extraction of compounds that could be responsible for antioxidant activity and anticancer potential. Methods: Defatted Gac seed kernel powder was extracted with different solvents: 100% water, 50% methanol:water, 70% ethanol:water, water saturated butanol, 100% methanol, and 100% ethanol. Trypsin inhibitors, saponins, phenolics, and antioxidant activity using the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and the ferric reducing antioxidant power (FRAP) assays; and anticancer potential against two melanoma cancer cell lines (MM418C1 and D24) were analysed to determine the best extraction solvents...
September 18, 2018: Medicines (Basel, Switzerland)
Pawan Kumar, Shailendra Kumar Singh, Vandana Handa, Himanshu Kathuria
Current topical minoxidil (MXD) formulations involve an unpleasant organic solvent which causes patient incompliance in addition to side effects in some cases. Therefore, the objective of this work was to develop an MXD formulation providing enhanced follicular delivery and reduced side effects. Oleic acid, being a safer material, was utilized to prepare the nanovesicles, which were characterized for size, entrapment efficiency, polydispersity index (PDI), zeta potential, and morphology. The nanovesicles were incorporated into the emugel Sepineo® P 600 (2% w / v ) to provide better longer contact time with the scalp and improve physical stability...
September 14, 2018: Medicines (Basel, Switzerland)
Leodevico L Ilag
Three recent studies revealed synergy between immune-checkpoint inhibitors and the microbiome as a new approach in the treatment of cancer. Incidentally, there has been significant progress in understanding the role of polyunsaturated fatty acids (PUFAs) in modulating cancer and the immune system, as well as in regulating the microbiome. Inflammation seems to be the common denominator among these seemingly unrelated biological entities-immune system, the microbiome, and long-chain polyunsaturated fatty acids (LC-PUFAs)...
September 10, 2018: Medicines (Basel, Switzerland)
Robert Hendler, Yue Zhang
The human microbiome plays many roles in inflammation, drug metabolism, and even the development of cancer that we are only beginning to understand. Colorectal cancer has been a focus for study in this field as its pathogenesis and its response to treatment have both been linked to the functioning of microbiota. This literature review evaluates the animal and human studies that have explored this relationship. By manipulating the microbiome with interventions such as probiotic administration, we may be able to reduce colorectal cancer risk and improve the safety and effectiveness of cancer therapy even though additional clinical research is still necessary...
September 7, 2018: Medicines (Basel, Switzerland)
Anja Thronicke, Shiao Li Oei, Antje Merkle, Harald Matthes, Friedemann Schad
Background : Despite improvement of tumor response rates, targeted therapy may induce toxicities in cancer patients. Recent studies indicate amelioration of adverse events (AEs) by add-on mistletoe ( Viscum album L., VA) in standard oncological treatment. The primary objective of this multicenter observational study was to determine the safety profile of targeted and add-on VA therapy compared to targeted therapy alone. Methods : Demographic and medical data were retrieved from the Network Oncology registry...
September 6, 2018: Medicines (Basel, Switzerland)
Gerhard Litscher
This Medicines special issue focuses on the further investigation, development, and modernization of acupuncture in basic research settings, as well as in clinical applications. The special issue contains 12 articles reporting latest evidence-based results of acupuncture research, and exploring acupuncture in general. Altogether 44 authors from all over the world contributed to this special issue.
September 4, 2018: Medicines (Basel, Switzerland)
Gema Nieto, Gaspar Ros, Julián Castillo
Nowadays, there is an interest in the consumption of food without synthetic additives and rather with the use of natural preservatives. In this regard, natural extracts of the Lamiaceae family, such as rosemary, have been studied because of its bioactive properties. Several studies have reported that rosemary extracts show biological bioactivities such as hepatoprotective, antifungal, insecticide, antioxidant and antibacterial. It is well known that the biological properties in rosemary are mainly due to phenolic compounds...
September 4, 2018: Medicines (Basel, Switzerland)
Gerhard Litscher
This editorial adopts a future-oriented technology. It describes a new modern helmet for transcranial laser stimulation and a way to quantify effects of this possible therapeutical method using near-infrared spectroscopy.
September 3, 2018: Medicines (Basel, Switzerland)
Kendall G Byler, William N Setzer
Background: Frankincense, the oleo-gum resin of Boswellia trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Methods: In this work, we have carried out a reverse docking study of Boswellia diterpenoids and triterpenoids with a library of 16034 potential druggable target proteins...
August 31, 2018: Medicines (Basel, Switzerland)
Xiaojuan Shang, Luquan Chen, Gerhard Litscher, Yanxia Sun, Chuxiong Pan, Cun-Zhi Liu, Daniela Litscher, Lu Wang
Background: Lifestyle risks for myopia are well known and the disease has become a major global public health issue worldwide. There is a relation between reading, writing, and computer work and the development of myopia. Methods: Within this prospective pilot study in 44 patients aged between 6 and 12 years with myopia we compared possible treatment effects of acupuncture or moxibustion. The diopters of the right and left eye were evaluated before and after the two treatment methods. Results: Myopia was improved in 14 eyes of 13 patients (15...
August 31, 2018: Medicines (Basel, Switzerland)
Maurits van den Noort, Peggy Bosch
This editorial is an introduction to the special issue 'Schizophrenia and Sleep Disorders'.[…].
August 30, 2018: Medicines (Basel, Switzerland)
Duangjai Tungmunnithum, Areeya Thongboonyou, Apinan Pholboon, Aujana Yangsabai
Phenolic compounds as well as flavonoids are well-known as antioxidant and many other important bioactive agents that have long been interested due to their benefits for human health, curing and preventing many diseases. This review attempts to demonstrate an overview of flavonoids and other phenolic compounds as the interesting alternative sources for pharmaceutical and medicinal applications. The examples of these phytochemicals from several medicinal plants are also illustrated, and their potential applications in pharmaceutical and medical aspects, especially for health promoting e...
August 25, 2018: Medicines (Basel, Switzerland)
Gerhard Litscher
This editorial contains an overview of the current status of published articles (pubmed) on the subject of laser acupuncture research. Ordered by country, a rough analysis is carried out.
August 20, 2018: Medicines (Basel, Switzerland)
Francesca Gado, Maria Digiacomo, Marco Macchia, Simone Bertini, Clementina Manera
Recent findings highlight the emerging role of the endocannabinoid system in the control of symptoms and disease progression in multiple sclerosis (MS). MS is a chronic, immune-mediated, demyelinating disorder of the central nervous system with no cure so far. It is widely reported in the literature that cannabinoids might be used to control MS symptoms and that they also might exert neuroprotective effects and slow down disease progression. This review aims to give an overview of the principal cannabinoids (synthetic and endogenous) used for the symptomatic amelioration of MS and their beneficial outcomes, providing new potentially possible perspectives for the treatment of this disease...
August 15, 2018: Medicines (Basel, Switzerland)
Mark O'Beirn, Helen Benghiat, Sara Meade, Geoff Heyes, Vijay Sawlani, Anthony Kong, Andrew Hartley, Paul Sanghera
Stereotactic radiosurgery (SRS) has become increasingly important in the management of brain metastases due to improving systemic disease control and rising incidence. Initial trials demonstrated SRS with whole-brain radiotherapy (WBRT) improved local control rates compared with WBRT alone. Concerns with WBRT associated neurocognitive toxicity have contributed to a greater use of SRS alone, including for patients with multiple metastases and following surgical resection. Molecular information, targeted agents, and immunotherapy have also altered the landscape for the management of brain metastases...
August 14, 2018: Medicines (Basel, Switzerland)
Aicha Hennia, Maria Graça Miguel, Said Nemmiche
Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids...
August 11, 2018: Medicines (Basel, Switzerland)
Lauren Stummer, Marija Markovic, Megan E Maroney
Background: Symptoms of sleep disorders, such as disturbances in sleep initiation and continuity, are commonly reported in patients with schizophrenia, especially in the acute phase of illness. Studies have shown that up to 80% of patients diagnosed with schizophrenia report symptoms of insomnia. Sleep disturbances have been shown to increase the risk of cognitive dysfunction and relapse in patients with schizophrenia. Currently, there are no medications approved specifically for the treatment of insomnia in patients with schizophrenia...
August 11, 2018: Medicines (Basel, Switzerland)
Yasuyoshi Miyata, Tomohiro Matsuo, Kyohei Araki, Yuichiro Nakamura, Yuji Sagara, Kojiro Ohba, Hideki Sakai
Green tea and green tea polyphenols (GTPs) are reported to inhibit carcinogenesis and malignant behavior in several diseases. Various in vivo and in vitro studies have shown that GTPs suppress the incidence and development of bladder cancer. However, at present, opinions concerning the anticancer effects and preventive role of green tea are conflicting. In addition, the detailed molecular mechanisms underlying the anticancer effects of green tea in bladder cancer remain unclear, as these effects are regulated by several cancer-related factors...
August 10, 2018: Medicines (Basel, Switzerland)
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"