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Medicines (Basel, Switzerland)

Jacob M Vigil, Sarah S Stith, Jegason P Diviant, Franco Brockelman, Keenan Keeling, Branden Hall
Background : We use a mobile software application (app) to measure for the first time, which fundamental characteristics of raw, natural medical Cannabis flower are associated with changes in perceived insomnia under naturalistic conditions. Methods : Four hundred and nine people with a specified condition of insomnia completed 1056 medical cannabis administration sessions using the Releaf AppTM educational software during which they recorded real-time ratings of self-perceived insomnia severity levels prior to and following consumption, experienced side effects, and product characteristics, including combustion method, cannabis subtypes, and/or major cannabinoid contents of cannabis consumed...
July 11, 2018: Medicines (Basel, Switzerland)
Jean-Jacques Michaille, Victoria Piurowski, Brooke Rigot, Hesham Kelani, Emily C Fortman, Esmerina Tili
Resveratrol (trans-3,5,4′-trihydroxystilbene, RSV) is a non-flavonoid dietary polyphenol with antioxidant, anti-inflammatory and anti-cancer properties that is primarily found in red berries. While RSV displays many beneficial effects in vitro, its actual effects in vivo or in animal models remain passionately debated. Recent publications suggest that RSV pleiotropic effects could arise from its capability to regulate the expression and activity of microRNAs, short regulators themselves capable of regulating up to several hundreds of target genes...
July 9, 2018: Medicines (Basel, Switzerland)
Charline Florence Awounfack, Marie Alfrede Mvondo, Stéphane Zingue, Sylvin Benjamin Ateba, Sefirin Djiogue, Rosette Megnekou, Derek Tantoh Ndinteh, Dieudonné Njamen
Background: Despite the wide use of leaves of Myrianthus arboreus (Cecropiaceae) in several African countries including Cameroon as food and against amenorrhea and female infertility, it has never been tested for this purpose. Methods: Using immature female Wistar rats, the impact of M. arboreus on the sexual maturation parameters (vaginal opening, ovarian relative weight and follicle maturation, gonadotropins and ovarian hormones serum levels) and fertility index has been evaluated through a 30-day oral administration of aqueous and methanol extracts of leaves at the doses of 20, 110 and 200 g/kg/day...
July 7, 2018: Medicines (Basel, Switzerland)
Leo Druart, Nicolas Pinsault
Background: The use of complementary and alternative medicine (CAM) is growing every year. The extent of its use is still not clear, and it is difficult to undertake comparative studies due to the variety of data collection tools used. Therefore, a standardized International Complementary and Alternative Medicine Questionnaire (I-CAM-Q) has been recommended to determine data about its usage. The purpose of the present study is to present a controlled translation of the questionnaire into French which is also properly adapted to a French audience...
July 6, 2018: Medicines (Basel, Switzerland)
Lucky Legbosi Nwidu, Ekramy Elmorsy, Jonah Sydney Aprioku, Iyeopu Siminialayi, Wayne Grant Carter
This study evaluated Moringa oleifera extracts from two locations in Niger Delta for in vitro anti-cholinesterase and antioxidant activities. Methanolic, aqueous and ethanolic extracts of Moringa oleifera were evaluated for inhibition of acetylcholinesterase (AChE) activity, antioxidant properties, and total phenolic and flavonoid contents using standard procedures. M. oleifera extracts possessed significant and concentration dependent AChE inhibitory activity for methanolic, aqueous, and ethanolic extracts...
July 5, 2018: Medicines (Basel, Switzerland)
Anh V Le, Sophie E Parks, Minh H Nguyen, Paul D Roach
BACKGROUND: Gac ( Momordica cochinchinensis Spreng.) seeds contain saponins that are reportedly medicinal. It was hypothesised that the extraction of saponins from powdered Gac seed kernels could be optimised using microwave-assisted extraction (MAE) with ethanol as the extraction solvent. The aim was to determine an appropriate ethanol concentration, ratio of solvent to seed powder and microwave power and time for extraction. Whether or not defatting the Gac seed powder had an impact on the extraction of saponins, was also determined...
July 3, 2018: Medicines (Basel, Switzerland)
Ranmali Ranasinghe, Rajaraman Eri
C-C chemoattractant cytokine (chemokine) receptor 6 (CCR6) and its exclusive binding molecule CCL20 is an extremely important chemokine receptor-ligand pair which controls cell migration and immune induction during inflammatory disease. Not many scientific studies have been undertaken to study its immune mechanisms in detail, but its unique contribution to steady state cell chemotaxis in upholding immune tolerance and regulating immune homeostasis during inflammation is evident in multiple systems in the human body, including skin, liver, lung, kidney, brain, eye, joints, gonads and the gut...
July 2, 2018: Medicines (Basel, Switzerland)
Adriana Harbuzariu, Gabriela M Oprea-Ilies, Ruben R Gonzalez-Perez
There is accumulating evidence that deregulated Notch signaling affects cancer development, and specifically pancreatic cancer (PC) progression. Notch canonical and non-canonical signaling has diverse impact on PC. Moreover, the actions of RBP-Jk (nuclear partner of activated Notch) independent of Notch signaling pathway seem to affect differently cancer progression. Recent data show that in PC and other cancer types the adipokine leptin can modulate Notch/RBP-Jk signaling, thereby, linking the pandemic obesity with cancer and chemoresistance...
July 2, 2018: Medicines (Basel, Switzerland)
Sherelle L Casey, Christopher W Vaughan
Chronic neuropathic pain is a prevalent condition that places a heavy burden on individuals and the healthcare system. Current medications have limitations and new approaches are needed, particularly given the current opioid crisis. There is some clinical evidence that the plant Cannabis sativa produces relief from neuropathic pain. However, current meta-analyses suggest that this efficacy is limited and there are problems with side effects. Most of this clinical research has examined whole cannabis, the psychoactive phytocannabinoid 9-tetrahydrocannabinol (THC), and nabiximols, which are a mixture of THC and the non-psychoactive phytocannabinoid cannabidiol...
July 1, 2018: Medicines (Basel, Switzerland)
Jan Schjøtt, Ylva Böttiger, Per Damkier, Linda Amundstuen Reppe, Jens Peter Kampmann, Hanne Rolighed Christensen, Olav Spigset
Background: The aim of this study was to compare use of references in responses from Scandinavian drug information centres (DICs). Methods: Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The six queries concerned adverse effects, pharmacokinetics, pregnancy, complementary medicine, polypharmacy, and breast feeding. References in the responses were categorised into five types of drug information sources: primary (original studies), secondary (reviews), tertiary (drug monographs, handbooks, etc...
July 1, 2018: Medicines (Basel, Switzerland)
Agostino Cristaudo, Mitchell Hickman, Charles Fong, Paul Sanghera, Andrew Hartley
Integrating immunotherapy, proton therapy and biological dose escalation into the definitive chemoradiation of oropharyngeal cancer poses several challenges. Reliable and reproducible data must be obtained in a timely fashion. However, despite recent international radiotherapy contouring guidelines, controversy persists as to the applicability of such guidelines to all cases. Similarly, a lack of consensus exists concerning both the definition of the organ at risk for oral mucositis and the most appropriate endpoint to measure for this critical toxicity...
June 27, 2018: Medicines (Basel, Switzerland)
Crystal L Park, Beth S Russell, Michael Fendrich
Alcohol and other drug (AOD) misuse is highly prevalent among young adults and creates myriad long-term problematic social, economic, and health consequences. Current treatments aimed at preventing or alleviating AOD misuse have demonstrated fairly inconsistent and weak effectiveness and, thus, are far from a complete solution. In this review, we describe the current state of AOD interventions for young adults and present an alternative emotion regulation framework for understanding AOD use/misuse. We then describe implications of this framework for interventions to promote healthier emotion regulation to successfully reduce AOD use/misuse...
June 27, 2018: Medicines (Basel, Switzerland)
Tiaw-Kee Lim, Yan Ma, Frederic Berger, Gerhard Litscher
Within the last 10 years, the percentage of low back pain (LBP) prevalence increased by 18%. The management and high cost of LBP put a tremendous burden on the healthcare system. Many risk factors have been identified, such as lifestyle, trauma, degeneration, postural impairment, and occupational related factors; however, as high as 95% of the cases of LBP are non-specific. Currently, LBP is treated pharmacologically. Approximately 25 to 30% of the patients develop serious side effects, such as drowsiness and drug addiction...
June 25, 2018: Medicines (Basel, Switzerland)
Jimmy T Efird, Sharyn Hunter, Sally Chan, Sarah Jeong, Susan L Thomas, Charulata Jindal, Tithi Biswas
Background: Radiotherapy (RT) plays an important role in the management and survival of patients with breast cancer. The aim of this study was to examine the association between age, comorbidities and use of RT in this population. Methods: Patients diagnosed with breast cancer from 2004⁻2013 were identified from the American College of Surgeons National Cancer Database (NCDB). Follow-up time was measured from the date of diagnosis (baseline) to the date of death or censoring. Adjusted hazard ratios (aHR) and 95% confidence intervals (95% CI) were used as the measure of association...
June 25, 2018: Medicines (Basel, Switzerland)
Maria Graça Miguel, Custódia Gago, Maria Dulce Antunes, Soraia Lagoas, Maria Leonor Faleiro, Cristina Megías, Isabel Cortés-Giraldo, Javier Vioque, Ana Cristina Figueiredo
Background: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+• ) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC)...
June 21, 2018: Medicines (Basel, Switzerland)
Mara Turri, Francesco Teatini, Francesco Donato, Giampietro Zanette, Valeria Tugnoli, Luciano Deotto, Bruno Bonetti, Giovanna Squintani
Background. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) (nabiximols or Sativex® ) is an oromucosal spray formulation containing THC and CBD at an approximately 1:1 fixed ratio. Its administration for the treatment of pain in patients with multiple sclerosis (MS) has been established. MS patients generally complain of different kinds of pain, including spasticity-related and neuropathic pain. In this study, we compared and evaluated pain modulation and thermal/pain threshold of MS patients before and after THC/CBD administration...
June 21, 2018: Medicines (Basel, Switzerland)
Joseph Baumgarden, Penelope Klein, George Picard
Background: Chronic back pain is one of the leading causes of disability and decreased quality of life for people in both their personal and professional lives. In addition to modern medical intervention, many individuals seek relief through complementary and alternative therapies. Design: This study was designed as a retrospective descriptive review presented as two case studies. Methods: Data were collected through face-to-face interviews with two volunteer subjects of convenience who each had a medical diagnosis of chronic back pain...
June 21, 2018: Medicines (Basel, Switzerland)
Diane D McConnell, Joe W McGreevy, Macy N Williams, N Scott Litofsky
Background: Cancer patients often take over-the-counter anti-oxidants as primary treatment or in combination with chemotherapy. Data about such use in glioblastoma is limited. Methods: Cultured U87-MG cells, a primary glioblastoma cell line (MU1454), U87-MG derived stem-like cells (scU87), and MU1454 derived stem-like cell lines (scMU1454) were pre-treated with one of three anti-oxidants—Vitamin D₃, Melatonin, and alpha-lipoic acid (LA)—for 72 h, followed by a 72 h treatment with temozolomide (TMZ)...
June 20, 2018: Medicines (Basel, Switzerland)
Hiroshi Kuge, Hidetoshi Mori, Tateyuki Morisawa, Kazuyo Hanyu, Junji Miyazaki, Mayumi Watanabe, Tim Hideaki Tanaka
Background: Indirect moxibustion (IM) has been previously performed between the spinous process while recording skin temperature of the trunk. However, moxibustion is often applied not only to acupuncture points on the back, but also to points located on the limbs. Thus, there is a need to investigate skin temperature (ST) responses following IM applied to the limbs. Methods: In Experiment 1 (Exp 1), subjects were randomly assigned to three groups: the left IM stimulation, right IM stimulation and control groups...
June 15, 2018: Medicines (Basel, Switzerland)
Katharina Murg, Wolfgang Raith, Berndt Urlesberger
Background: We are reporting here about a 3-month-old boy with a history of failure to thrive, hypertrophic obstructive cardiomyopathy and neurological misbehaviour including hypotension in body muscles, who was found to have screaming attacks, agitation and restlessness. Methods/Results: Body and ear acupuncture was used both as supporting and integrative therapy to reduce the phases of restlessness and screaming and, simultaneously, the use of hypnotic drugs, as well as to improve the baby’s thriving...
June 13, 2018: Medicines (Basel, Switzerland)
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